Metabolic Pathways of Acylcarnitine Synthesis
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTAcylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry-based techniques to provide new information on metabolite structure. We summarized the nomenclature of acylcarnitines based on historical common names and common abbreviations, and we propose the use of systematic abbrevi...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: J Brejchova K Brejchova O Kuda Source Type: research

Nutrition and Bone Marrow Adiposity in Relation to Bone Health
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTBone remodeling is energetically demanding process. Energy coming from nutrients present in the diet contributes to function of different cell type including osteoblasts, osteocytes and osteoclasts in bone marrow participating in bone homeostasis. With aging, obesity and osteoporosis the function of key building blocks, bone marrow stromal cells (BMSCs), changes towards higher accumulation of bone marrow adipose tissue (BMAT) and decreased bone mass, which is affected by diet and sex dimorphism. Men and women have unique nutritional needs based on physiological and ho...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: M Dzubanova A Benova M Ferencakova R Coupeau M Tencerova Source Type: research

Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity
We present indications that muscle NST may be adaptive but not facultative, unlike UCP1-dependent NST. Due to its slow regulation and low energy efficiency, reflecting in part the anatomical location, induction of muscle NST may counteract development of obesity more effectively than UCP1-dependent thermogenesis in BAT.PMID:38752772 (Source: Physiological Research)
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: K Bardova P Janovska A Vavrova J Kopecky P Zouhar Source Type: research

Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTStarting from simple clinical statistics, the spectrum of methods used in epilepsy research in the Institute of Physiology of the Czechoslovak (now Czech) Academy of Sciences progressively increased. Professor Servít used electrophysiological methods for study of brain activity in lower vertebrates, neuropathology was focused on electronmicroscopic study of cortical epileptic focus and ion-sensitive microelectrodes were used for studies of cortical direct current potentials. Developmental studies used electrophysiological methods (activity and projection of cortical ...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: P Mare š Source Type: research

Metabolic Pathways of Acylcarnitine Synthesis
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTAcylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry-based techniques to provide new information on metabolite structure. We summarized the nomenclature of acylcarnitines based on historical common names and common abbreviations, and we propose the use of systematic abbrevi...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: J Brejchova K Brejchova O Kuda Source Type: research

Nutrition and Bone Marrow Adiposity in Relation to Bone Health
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTBone remodeling is energetically demanding process. Energy coming from nutrients present in the diet contributes to function of different cell type including osteoblasts, osteocytes and osteoclasts in bone marrow participating in bone homeostasis. With aging, obesity and osteoporosis the function of key building blocks, bone marrow stromal cells (BMSCs), changes towards higher accumulation of bone marrow adipose tissue (BMAT) and decreased bone mass, which is affected by diet and sex dimorphism. Men and women have unique nutritional needs based on physiological and ho...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: M Dzubanova A Benova M Ferencakova R Coupeau M Tencerova Source Type: research

Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity
We present indications that muscle NST may be adaptive but not facultative, unlike UCP1-dependent NST. Due to its slow regulation and low energy efficiency, reflecting in part the anatomical location, induction of muscle NST may counteract development of obesity more effectively than UCP1-dependent thermogenesis in BAT.PMID:38752772 (Source: Physiological Research)
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: K Bardova P Janovska A Vavrova J Kopecky P Zouhar Source Type: research

Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTStarting from simple clinical statistics, the spectrum of methods used in epilepsy research in the Institute of Physiology of the Czechoslovak (now Czech) Academy of Sciences progressively increased. Professor Servít used electrophysiological methods for study of brain activity in lower vertebrates, neuropathology was focused on electronmicroscopic study of cortical epileptic focus and ion-sensitive microelectrodes were used for studies of cortical direct current potentials. Developmental studies used electrophysiological methods (activity and projection of cortical ...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: P Mare š Source Type: research

Metabolic Pathways of Acylcarnitine Synthesis
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTAcylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry-based techniques to provide new information on metabolite structure. We summarized the nomenclature of acylcarnitines based on historical common names and common abbreviations, and we propose the use of systematic abbrevi...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: J Brejchova K Brejchova O Kuda Source Type: research

Nutrition and Bone Marrow Adiposity in Relation to Bone Health
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTBone remodeling is energetically demanding process. Energy coming from nutrients present in the diet contributes to function of different cell type including osteoblasts, osteocytes and osteoclasts in bone marrow participating in bone homeostasis. With aging, obesity and osteoporosis the function of key building blocks, bone marrow stromal cells (BMSCs), changes towards higher accumulation of bone marrow adipose tissue (BMAT) and decreased bone mass, which is affected by diet and sex dimorphism. Men and women have unique nutritional needs based on physiological and ho...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: M Dzubanova A Benova M Ferencakova R Coupeau M Tencerova Source Type: research

Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity
We present indications that muscle NST may be adaptive but not facultative, unlike UCP1-dependent NST. Due to its slow regulation and low energy efficiency, reflecting in part the anatomical location, induction of muscle NST may counteract development of obesity more effectively than UCP1-dependent thermogenesis in BAT.PMID:38752772 (Source: Physiological Research)
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: K Bardova P Janovska A Vavrova J Kopecky P Zouhar Source Type: research

Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTStarting from simple clinical statistics, the spectrum of methods used in epilepsy research in the Institute of Physiology of the Czechoslovak (now Czech) Academy of Sciences progressively increased. Professor Servít used electrophysiological methods for study of brain activity in lower vertebrates, neuropathology was focused on electronmicroscopic study of cortical epileptic focus and ion-sensitive microelectrodes were used for studies of cortical direct current potentials. Developmental studies used electrophysiological methods (activity and projection of cortical ...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: P Mare š Source Type: research

Metabolic Pathways of Acylcarnitine Synthesis
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTAcylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry-based techniques to provide new information on metabolite structure. We summarized the nomenclature of acylcarnitines based on historical common names and common abbreviations, and we propose the use of systematic abbrevi...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: J Brejchova K Brejchova O Kuda Source Type: research

Nutrition and Bone Marrow Adiposity in Relation to Bone Health
Physiol Res. 2024 May 15. Online ahead of print.ABSTRACTBone remodeling is energetically demanding process. Energy coming from nutrients present in the diet contributes to function of different cell type including osteoblasts, osteocytes and osteoclasts in bone marrow participating in bone homeostasis. With aging, obesity and osteoporosis the function of key building blocks, bone marrow stromal cells (BMSCs), changes towards higher accumulation of bone marrow adipose tissue (BMAT) and decreased bone mass, which is affected by diet and sex dimorphism. Men and women have unique nutritional needs based on physiological and ho...
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: M Dzubanova A Benova M Ferencakova R Coupeau M Tencerova Source Type: research

Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity
We present indications that muscle NST may be adaptive but not facultative, unlike UCP1-dependent NST. Due to its slow regulation and low energy efficiency, reflecting in part the anatomical location, induction of muscle NST may counteract development of obesity more effectively than UCP1-dependent thermogenesis in BAT.PMID:38752772 (Source: Physiological Research)
Source: Physiological Research - May 16, 2024 Category: Physiology Authors: K Bardova P Janovska A Vavrova J Kopecky P Zouhar Source Type: research