Bevacizumab-refractory radiation necrosis with pathologic transformation of benign meningioma following adjuvant gamma knife radiosurgery: A rare case report
Rationale: Bevacizumab has shown good efficacy in radiation necrosis (RN) following gamma knife radiosurgery (GKRS) and associated peritumoral edema. However, few studies have reported bevacizumab failure. Moreover, the pathologic transformation of benign meningioma following GKRS has never been reported. Patients concerns: A 41-year-old man was admitted with focal seizure on the right arm. Diagnoses: Magnetic resonance imaging (MRI) demonstrated a 4.7 cm-sized convexity meningioma involving left motor cortex. Interventions: Subtotally resected tumor was confirmed as a meningothelial meningioma and subsequentl...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Effects of gut microbiome-targeted therapies on cardiometabolic outcomes in children and adolescents: A protocol for systematic review and meta-analysis
Background: Emerging evidence indicates the role of gut microbiota in the development of cardiovascular diseases. Thus, gut microbiota is increasingly recognized as a potential therapeutic target of cardiovascular disease. However, the effects of gut microbiome-targeted therapies on cardiometabolic outcomes in children and adolescents remain unclear. Methods: We plan to perform a systematic search from PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science. Two authors will independently select the relevant studies and extract data according to a previously defined data extraction sheet. We...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Hepatic metastasis from a meningeal hemangiopericytoma: A case report
Conclusion: Here, we report a case of local brain tumor recurrence and multiple hepatic metastases from a MHPC. Craniotomy combined with radical metastasectomy may be useful in such cases. Detailed immunohistochemical staining is helpful to distinguish a MHPC from a meningioma. Long-term follow-up is recommended. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Therapeutic response to corticosteroids in a critically ill patient with COVID-19: A case report
Conclusions: Early use of moderate-dose corticosteroids over a short period may enhance recovery from COVID-19 in critically ill patients. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Acupuncture for treating chronic stable angina pectoris-associated anxiety and depression: A protocol for systematic review and meta-analysis
Conclusion: The conclusion of this study will be published in a peer-reviewed journal. Ethics and dissemination: This review will not involve private information of participants, so the ethical approval will not be required. The results will be disseminated in a peer-reviewed journal or conference presentation. Important protocol modifications will be updated on PROSPERO. PROSPERO registration number: CRD42020165492. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
Background: Bioresorbable vascular scaffolds (BVS) completely resorb within 3 years after placement into the coronary artery. The safety and effectiveness of bioabsorbable scaffolds are of critical importance during this 3-year period. Objective: We performed a meta-analysis to compare the safety and efficacy of BVS and second-generation drug-eluting stents (DES) at 3 years after implantation. Methods: Published randomized trials comparing BVS to second-generation DES for the treatment of coronary artery disease were identified within PubMed, EMBASE, Cochrane Library, Web of Science, and relevant Web sites with pub...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Differences in injury and trauma management between migrant workers and citizens
In Taiwan, legal migrant workers and almost all citizens are covered under the National Health Insurance program. Work-related injuries and various traumatic events constitute 2 major reasons for seeking medical care among migrant workers. Therefore, we conducted this retrospective study to delineate the clinical features of migrant workers with trauma and determine differences in trauma management between migrant workers and citizens under the current medical care and insurance system. We retrospectively reviewed the data of all patients with trauma who were discharged from adult wards between January 1, 2015 and Decembe...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Scrotoscopy and traditional open surgery shows a high degree of consistency in the diagnosis of testicular torsion: An initial report
Traditional open surgery (OS) is usually necessary when testicular torsion (TT) cannot be excluded by scrotal ultrasound. Scrotoscopy has been used as a minimally invasive technique to diagnose or treat scrotal diseases, and it may also play a role in diagnosing TT. A retrospective analysis was performed for patients with TT to evaluate the consistency of scrotoscopy and OS in the diagnosis of TT. In the cases where preoperational Color Doppler ultrasonography was performed, scrotoscopy, open surgery, and confirmed TT were included for future analysis. A total of 43 patients were studied. Twisted testes were retained in ...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

A comparison of noninvasive and invasive acupuncture in preventing postoperative nausea and vomiting: A protocol for systematic review and Bayesian network meta-analysis
Conclusion: Our results will help to improve the clinical decision-making ability and policy-making in PONV domain. Systematic review registration: The protocol has been registered on INPLASY 202060108. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Association of matrix metalloproteinase-12 polymorphisms with chronic obstructive pulmonary disease risk: A protocol for systematic review and meta analysis
Conclusion: Publishing this protocol will minimise the possibility of bias due to post hoc changes to the analysis protocol. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Breath therapy for patients with chronic nonspecific low back pain: A protocol of systematic review and meta-analysis
Conclusion: Our research will provide reliable evidence of breath therapy for CNLBP. Registration: International Prospective Register of Systematic Reviews (PROSPERO) CRD42020156340. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Hamstring autograft versus patellar tendon autograft for anterior cruciate ligament reconstruction, which graft has a higher contralateral anterior cruciate ligament injury rate?: A meta-analysis of 5561 patients following the PRISMA guidelines
Background: Contralateral anterior cruciate ligament (CACL) injury is one of the devastating complications after anterior cruciate ligament (ACL) reconstruction. Whether the risk of CACL tear is related to graft selection remains controversial due to contradictory results in studies. There are no meta-analyses to compare which graft has a higher CACL injury rate. Hence, this meta-analysis was conducted to compare the incidence of the CACL injury after ACL reconstruction with bone-patellar tendon-bone (BPTB) autografts compared with hamstring (HT) autografts. Methods: A comprehensive search of literature published betw...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Efficacy and safety of cinobufacini injection combined with vinorelbine and cisplatin regimen chemotherapy for stage III/IV non-small cell lung cancer: A protocol for systematic review and meta-analysis of randomized controlled trials
This study will systematically evaluate the efficacy and safety of cinobufacini combined with vinorelbine and cisplatin in the treatment of stage III/IV non-small cell lung cancer. The results of this systematic review will be published in peer-reviewed scientific journals. Ethics: The ethical approval is not required since systematic review is based on published studies. INPLASY registration number: INPLASY202060091. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

A comparison of the efficacy and safety of complementary and alternative therapies for premature ovarian insufficiency: A protocol for network meta-analysis
Conclusion: This work will provide high-quality evidence for clinicians in the field to build on for best practices in effective interventions (complementary and alternative therapies) for POI. Ethics and dissemination: This NMA is a secondary research which based on some previously published data. Therefore, the ethical approval was not necessary. PROSPERO registration number: CRD42020163873 (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

A study on respiratory management in acute postoperative period by nasal high flow for patients undergoing surgery under general anesthesia
This study aims to determine whether the postoperative hypoxemia and hypercapnia can be prevented by NHF without the requirement of supplemental oxygen. The study will recruit adult patients undergoing planned oral surgery under general anesthesia at Nagasaki University Hospital. It is a randomized parallel group comparative study with 3 groups: NHF with room air only and no supplemental oxygen, no respiratory support, and face mask oxygen administration. The study protocol will begin at the time that the patient is returned to the general ward and will finish 3 hours later. The primary endpoint is the time-weighted aver...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Poor oral health is associated with asthma, allergic rhinitis, and atopic dermatitis in Korean adolescents: A cross-sectional study
The purpose of this study was to evaluate the association between oral health and asthma/allergic rhinitis/atopic dermatitis in a large representative Korean adolescent population. A total of 136,027 participants (aged 12–18 years old) were selected from the Korea Youth Risk Behavior Web-based Survey 2014 to 2015. The subjects’ history of asthma, allergic rhinitis, and atopic dermatitis was determined by inquiring whether they had been diagnosed by a medical doctor within the previous 12 months or throughout life. Participants were asked if they had experienced the following 6 symptoms regarding oral health in...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Solitary metastasis to the skin and colon from gastric cancer after curative gastrectomy and chemotherapy: A case report
Rationale: Gastric cancer usually spread via blood circulation to liver, lung, bone, and kidney after recurrence, but it is extremely rare in clinical practice that gastric carcinoma metastasizes to the skin and colon without metastasis to common sites like liver or lung. Patient concerns: A 57-year-old man was admitted to the hospital with altered bowel habit and hematochezia for 2 weeks. Diagnoses: The patient was diagnosed with advanced gastric cancer at stage IIIA (pT3N2M0) two and a half years ago. Cutaneous metastasis from gastric cancer was confirmed by cutaneous biopsy 2 years following curative gastrectomy...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Primary thymic carcinoma with adenoid cystic carcinoma-like features: A case report and literature review
Rationale: Thymic carcinoma with adenoid cystic carcinoma-like features is a special subtype of thymic adenocarcinoma, and the occurrence of this condition is extremely rare. Herein, we report a case of primary thymic carcinoma with adenoid cystic carcinoma-like features in a young man. Patient concerns: A 38-year-old man had an incidental finding of space-occupying lesion in the anterior mediastinum during a routine health examination. The patient complained of occasional mild chest tightness during hot weather but had no obvious cough, sputum, chest pain, or fever. Contrast-enhanced computed tomography scan of the c...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Severe tetanus following ulcerated skin cancer: Case report
Rationale: Tetanus is usually caused by wound infection with Clostridium tetani after acute injuries. Skin cancer wound is a rarely reported cause of tetani infection. It is difficult to be diagnosed and mistaken for other brain lesions. Patient concerns: A 49-year-old man presenting with the only symptom of repeated convulsions was admitted to our department. He had an ulcerated skin cancer on the right buttock that had been excised in another hospital 1 month before admission, leaving the wound unhealed. He was suspected of having a metastatic brain tumor early, but exhibited a negative cranial CT-scan. Diagnosis: ...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Retropharyngeal hematoma secondary to cervical hyperextension in a minor collision trauma presenting with dyspnoea: A case report
Conclusion: Retropharyngeal hematoma that develops in young patients without visible injuries or severe symptoms after a minor trauma can easily go undetected. Although most hematomas under observation resolve spontaneously, the retropharyngeal hematomas missed at initial assessment may result in critical complications. High level of suspicion, repeated neck CT, and thorough tertiary survey in emergency rooms are helpful in avoiding missed life-threatening retropharyngeal hematoma. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Benign esophageal schwannoma: A case report and brief overview
Rationale: Schwannoma is a tumor of the peripheral nervous system that originated in the Schwann cells of the neural sheath. Esophageal schwannomas are rare esophageal submucosal tumors, comprising approximately 2% of esophageal tumors. Since the symptoms, signs, and images of esophageal schwannoma are not specific, its preoperative diagnosis remains challenging. Patient concerns: A 67-year-old woman visited our department with complaints of gradually developed dysphagia and dyspnea for 4 years. A chest computed tomography scan showed a well-demarcated, enhancing homogeneous tumor measuring 61 × 46 ×...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Pharyngeal perforation following laryngoscopy in a patient with dysphagia secondary to diffuse idiopathic skeletal hyperostosis: A case report
Rationale: Dysphagia is a common presenting symptom in elderly people. Nevertheless, dysphagia resulting from diffuse idiopathic skeletal hyperostosis (DISH) of patients’ cervical spine may be due to several factors. Despite computed tomography scan showing the size and shape of osteophytes, endoscopy may be necessary to exclude other intrinsic causes of dysphagia. Due to the anatomic variation of the pharynx secondary to DISH, patients undergoing endoscopy are at risk of perforation. Once perforation occurs, inappropriate treatments may finally lead to an irretrievable outcome. Patient concerns: A 58-year-old m...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Ileocolic intussusception caused by ileal lipoma: A case report
We describe the difficulties in diagnosis and treatment of this rare cause of intussusception and review the literature on adult intussusceptions. The ileal lipoma is a very rare cause of ileocolic intussusception. Abdominal CT and colonoscopy are important for the diagnosis of intussusception and abdominal lipomas. Surgical resection remains the treatment of choice. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

A novel application of tau PET in the diagnosis of sporadic inclusion body myositis: A case report
We presented a 46-year-old woman who suffered from progressive lower limb weakness for one and a half year. Diagnoses: Needle electromyography showed myogenic damage. Characteristic myopathological changes of sIBM were discovered, and abnormal tau protein deposits were identified by tau immunostaining. Genetic testing ruled out the GNE myopathy, a hereditary distal myopathy with rimmed vacuoles. The patient was finally diagnosed as sIBM. Interventions: We performed [18F] THK5317 PET/MRI on the patient. Outcomes: There were significantly increased tau uptake levels in the quadriceps muscles of sIBM patient. The upt...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Spontaneous pseudoaneurysm of the posterior tibial artery successfully treated by open surgery: Case report and review of the literature
Rationale: An extremely rare spontaneous pseudoaneurysm (PSA) of the posterior tibial artery (PTA) in a middle-aged male patient was cured by open surgery effectively. Patient concerns: A 53-year-old man presented with the increasing swollen left shank for 1 day, with intermittent pain, pulselessness and pallor. He denied the history of trauma, infection, and other diseases. Diagnoses: Physical examination, past medical history, ankle brachial index, ultrasonography, computed tomographic angiography (CTA), 3-dimensional reconstruction image of the popliteal artery and its branches and histological examination of in...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome associated spinal subdural hematoma: A case report
We report the unique case of a 40-year-old female presented with crescendo headache, blurred vision, and recurrent generalized tonic–clonic seizure. She had a minor neck injury 1 week before but attracted no more attention. Neurological tests on admission yielded a Glasgow Coma Scale score of 13. No obvious focal neurological deficit apart from positive signs of meningeal irritation was presented. Diagnoses: Xanthochromia and hemorrhagic cerebrospinal fluid with pleocytosis was found on lumbar puncture. Cranial computed tomography was negative but magnetic resonance imaging demonstrated bilateral areas of vasogeni...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Pilar cyst on the dorsum of hand: A case report and review of literature
Conclusion: Pilar cyst rarely occurs on the dorsum of hand and its diagnosis depends on histopathological examinations. Surgical resection is the only way to treat it. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Premature closure of the distal radial physis without evident history of trauma: A case report
We present a case of premature closure of the distal radial physis without evident history of trauma in a girl. Patient concerns: A 14-year-old girl presented with chronic progressive deformity and painful functional limitation of her right forearm. The right wrist pain had begun when the patient was 5 years old. There was no evident history of trauma. The deformity and persistent right wrist pain had prevented her from performing sports activities and activities of daily living. Diagnoses: Radiography and computed tomography showed a volarly angulated distal radius and dorsally protruding distal ulna with a length d...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Intraventricular cystic papillary meningioma: A case report and literature review
Conclusion: The diagnosis of intraventricular cystic papillary meningioma depends mainly on its histology and imaging features. Total resection and adjuvant radiotherapy can result in a relatively good prognosis of patients with intraventricular cystic papillary meningiomas. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury: A case series
Background: Cardiac injury and coagulation disorders have been two increasing concerns in the management of patients with severe coronavirus disease (COVID-19). Coagulation disorders in COVID-19 patients with cardiac injury have not been characterized. Methods: We analyzed the data of five COVID-19 patients with cardiac injury who had D-dimer surge (defined as a rapid increase in the D-dimer level in 72 h, from (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

SARS-CoV-2 infection associated with micturition syncope: Our experience with 4 case reports
We present 4 cases of COVID-19 hospitalized in the Department of Infectious Diseases of the Academic Emergency Hospital Sibiu, Romania, cases that presented micturition syncope. Diagnoses: During hospitalization, patients confirmed with SARS-Cov-2 infection using real time reverse transcriptase-polymerase chain reaction (RT-PCR) assay, presented micturition syncope in different stages of the infection (at the beginning and in the second week of evolution). Interventions: Other causes of syncope such as adrenal insufficiency secondary to corticosteroids treatment, cardiac rhythm disorders, neurological impairment, deh...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Inflammatory cytokine levels in multiple system atrophy: A protocol for systematic review and meta-analysis
Conclusion: To the best of our knowledge, this study will be the first meta-analysis that provides the quantitative evidence of inflammatory cytokine levels in MSA. Registration Number: INPLASY202060034. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Is it worth to explore the contralateral side in unilateral childhood inguinal hernia?: A PRISMA-compliant meta-analysis
Background: It is still not clear if the contralateral side should be explored in children with unilateral inguinal hernias. The primary aim of the present study was to assess the incidence of metachronous contralateral inguinal hernias (MCIHs) in the pediatric population. The second aim was to assess factors associated with increased risk of MCIH development. Methods: Prospective studies including patients from 0-19 years undergoing unilateral inguinal hernia repair without surgical exploration of the contralateral side between 1947 and April 2020 with a minimal follow-up of one year were searched. Searches included ...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Can acoustic radiation force impulse imaging (ARFI) accurately diagnose renal masses?: A protocol of systematic review and meta-analysis
Conclusion: This study will summarize the most recent evidence that focusing on the diagnosis of ARFI for renal masses. Study registration: INPLASY202060105. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Cortical thickness in chronic pain: A protocol for systematic review and meta-analysis
Conclusions: To the best of our knowledge, this will be the first CBMA of SBM studies that characterizes brain CTh alterations in CP. The CBMA will provide the quantitative evidence of common brain cortical morphometry of CP. The findings will help us to understand the neural basis underlying CP. Trial Registration number: INPLASY202050069 (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Non-pharmacological interventions for postpartum depression: A protocol for systematic review and network meta-analysis
Conclusion: The review results will ascertain the hierarchy of effectiveness of different non-pharmacological approaches for PPD, and systematically provide suggests for physicians and patients. Trial registration number: PROSPERO CRD42020166801 (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Real dynamic assessment of tear film optical quality for monitoring and early prevention of dry eye
To evaluate real dynamic assessment of tear film optical quality for monitoring and prevention of dry eye. Right eyes of 62 normal and 39 dry eye subjects were included. Dynamic measurement of objective scatter index (OSI) was performed by using the Optical Quality Analysis System II (OQAS II), correlation coefficient between OSI and time (CCOT) was calculated. According to whether the CCOT was significantly ascending, normal and dry eye groups were further subdivided for comparison. By using Scheimpflug-Placido topographer, non-invasive tear break-up time (NITBUT) was recorded, and a 2-dimensional precorneal tear film ma...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Alteration and association between serum ACE2/ angiotensin(1-7)/Mas axis and oxidative stress in chronic kidney disease: A pilot study
In this study, we aimed to detected serum ACE2/Ang (1-7)/Mas axis, OS conditions and described its clinical associations in patients with CKD at different stages. A total of 48 patients with CKD and 6 healthy controls (CT) were enrolled, and serum angiotensin converting enzyme (ACE), ACE2, Ang (1-7), 8-hydroxy-2’-deoxyguanosine (8-OHdG) were determined by ELISA. Serum extracellular glutathione peroxidase(eGSH-Px) activity and renal functions were determined by the biochemical method. Serum ACE and ACE2 levels in CKD stages 3 to 5 and serum Ang(1-7) levels in CKD stages 4 to 5 without Ang II receptor blockers treatm...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Th17/Treg imbalance in patients with severe acute pancreatitis: Attenuated by high-volume hemofiltration treatment
Background: To investigate the effect of high-volume hemofiltration (HVHF) on Th17/Treg imbalance in patients with severe acute pancreatitis (SAP). Methods: Forty-two patients with SAP were randomly received 24 hours of continuous HVHF (n = 21) or without HVHF (n = 21). At day 28, all 42 patients were divided into survival group (n = 32) and non-survival group (n = 10). Venous blood samples collected at 0, 6, 12, and 24 hours during HVHF treatment (or equivalent time in non-HVHF group) were assessed by flow cytometry to detect Th17 and Treg cells. Concentrations of IL-6, IL-17, IL-10, and TGF-&beta...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

A meta-analysis of the therapeutic effect of gefitinib combined with chemotherapy and chemotherapy alone in treating non-small cell lung cancer
This study aimed to summarize the currently available evidence and compare the efficacy and safety of gefitinib combined with chemotherapy versus chemotherapy alone for treating advanced NSCLC. Methods: Literature on comparing the effects of gefitinib combined with chemotherapy and chemotherapy alone in treating NSCLC was retrieved from the PubMed, EMBASE and Cochrane Database. The primary outcome measures included progression-free survival (PFS) and overall survival (OS). Revman 5.3 was used for data processing. Results: Seven randomized controlled trials were included, involving a total of 1418 patients. There appe...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Prognosis of COVID-19 in patients with breast cancer: A protocol for systematic review and meta-analysis
Conclusion: This study will provide comprehensive evidence for medical staff to adopt effective treatment strategies for breast cancer patients during the COVID-19 pandemic. PROSPERO registration number: CRD42020188208. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Angiography in pediatric patients: Measurement and estimation of femoral vessel diameter
The diameter of femoral vessels was angiographically explored in pediatric patients with congenital heart disease (CHD) and compared with anthropometric and demographic indexes. A total of 153 pediatric patients younger than 3 years old were recruited. The sex, age, weight, and height of patients were recorded daily, and the body surface area (BSA) was calculated with the Mosteller formula. The values of mean left-right diameters were 3.13 (0.32) mm for the femoral artery (FA) and 5.14 (0.68) mm for the femoral vein (FV). The FA diameter (FA-Dm) and FV diameter (FV-Dm) were clearly related (R = 0.84, P  (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Effects of Yangxinshi tablet on exercise tolerance in patients with coronary heart disease: A protocol of randomized, double-blind, placebo-controlled, and multi-center trial
This study protocol was registered in Research Registry (researchregistry5752). (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Catheter ablation of a latent accessory pathway under continuous infusion of adenosine: A case report
Rationale: In absence of conduction over the accessory pathway (AP) during the electrophysiological study, mapping and ablation is impossible. Various techniques can be used to activate absent conduction. In this presentation we describe the first case of latent AP ablation performed under continuous infusion of adenosine. Patient concerns: A 65-year-old man, presented to emergency department with atrial fibrillation and antegrade conduction through a left lateral AP. He had palpitations and lightheadedness that occurred every 2 to 3 weeks. Diagnosis: The electrophysiological study confirmed a latent left-side AP. ...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Novel exploration of 3D printed personalized total elbow arthroplasty to solve the severe bone defect after internal fixation failure of comminuted distal humerus fracture: A case report
Rationale: Severe bone defect could often occur after removing the fractured fixation plates of comminuted fracture in the distal humerus. The reoperation of internal fixation or conventional total elbow arthroplasty could hardly restore the anatomy structure and function of the elbow. However, a novel exploration of 3-dimensional (3D) printed personalized elbow prosthesis was presented in this work. This is a rare and successful treatment for the severe bone defect after removing the fractured fixation plates of comminuted distal humerus fracture. Patient concerns: A 60-year-old male patient was admitted to the hospi...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

MMP-9-C1562T polymorphism and susceptibility to chronic obstructive pulmonary disease: A meta-analysis
Background: To comprehensively evaluate the association between the polymorphism of matrix metalloproteinase-9 (MMP-9)-C1562T (rs3918242) and susceptibility to chronic obstructive pulmonary disease (COPD) in middle-aged and elderly patients through Meta-analysis. Methods: PubMed, EMBASE, CNKI, Wanfang, VIP, and other databases were searched by computer in the inception to August 2019 to collect all the case-control studies that met the inclusion criteria in this literature. Meta-analysis was performed using Stata 15.0, including the OR value calculations of the association between the merged MMP-9-C1562T polymorphism ...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Acute calcific periarthritis of the proximal phalangeal joint on the fifth finger: A case report and literature review
We present a rare case of acute calcific periarthritis around the proximal phalangeal joint of the left fifth finger that took a long time to spontaneously resolve, and review previous reports of similar cases. Patient concerns: A 69-year-old woman complained of longstanding pain and swelling of the fifth finger of the left hand. She had visited several clinics and hospitals and had been treated with analgesics and splinting for more than 2 months, but the pain in the finger had gradually worsened. Diagnoses: Blood chemistry analysis showed no signs of inflammation or other abnormalities. Radiographs revealed a well-...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Variation of insertion of the pectoralis major in a cadaveric study: A case report
This study is important for orthopedic and rehabilitation physicians in treating diseases of the long head of the biceps brachii tendon. As part of management, the condition of the tendon of the pectoralis major should be confirmed using magnetic resonance imaging or echocardiography. (Source: Medicine)
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Unrecognized tibial nerve injury in total-ankle arthroplasty: Two case reports
Rationale: Tibial nerve injury is a sustainable but rare complication during total-ankle arthroplasty (TAA). We outlined 2 previously unreported cases of tibial nerve injury in TAA, including the prognoses and possible causes. Patient concerns: First, a 63-year-old woman complained of a 5-month history of persistent tingling sensation and numbness on the medial and plantar aspects of her foot after TAA. Second, a 50-year-old woman complained of a 6-month history of tingling sensation and numbness on the plantar surface of her forefoot after TAA. Diagnosis: Explorations were performed on suspicion of tarsal tunnel s...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Mucinous cystic neoplasms of the pancreas associated with pregnancy: Two case reports
Rationale: Although rare, pancreatic neoplasms can occur during pregnancy, both in benign and malignant forms. Mucinous cystic neoplasms (MCNs) of the pancreas, a type of these neoplasms, are precursor lesions to invasive pancreatic cancer. The presence of the ovarian-type stroma is a defining feature. Patient concerns: The first case was a 38-year-old woman in her 18th week of pregnancy with abdominal pain that worsens a few weeks later. The second case was a 30-year-old woman in her 17th week of pregnancy with abdominal pain in the left hypochondrium. Diagnosis: The patients were under clinical examination and la...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research