Evidence and issues in addressing cost-effectiveness in treating obesity
Healthcare systems that provide care free of charge at the point of care must evaluate health interventions for effectiveness and cost-effectiveness. This is as true for treatments for obesity as it is for any disease area, and the same money cannot be spent at the same time on obesity and other disease areas necessitating these evaluations. Cost –utility analyses carried out to inform payers typically ask whether a new health intervention makes people live longer and/or better than the existing standard of care. (Source: Medicine)
Source: Medicine - February 12, 2019 Category: Internal Medicine Authors: Amanda Adler Tags: Obesity Source Type: research

Management of obesity and overweight
Modern weight management incorporates optimization of health and risk factors, irrespective of weight change, short-term weight loss and long-term prevention of weight gain/regain. Patients with excess body fat and elevated metabolic risks needing professional weight management can be identified by a large waist (>102 cm for men,>88 cm for women. A modest weight loss of 5 –10 kg is achievable by many conventional dietary intervention methods, with multiple small benefits. However, this is usually insufficient to improve quality of life sufficiently for people to maintain their reduced weight. (Source: Medicine)
Source: Medicine - February 12, 2019 Category: Internal Medicine Authors: Michael EJ. Lean Tags: Obesity Source Type: research

The cost of malnutrition – predictions for the next 25 years
As societal challenges go, a condition that affects 25% of hospital admissions, that contributes to 15% of the health and social care budget and for which we have an evidence-based and cost-saving approach should be a key priority for every healthcare system. Yet undernutrition remains a skeleton in the closet. It is underemphasized in public health priorities, under-taught in the medical curriculum and under-resourced in terms of trained healthcare professionals identifying and managing the problem. (Source: Medicine)
Source: Medicine - February 8, 2019 Category: Internal Medicine Authors: Mike Wallace Tags: Undernutrition Source Type: research

Micronutrient deficiencies, vitamin pills and nutritional supplements
In the 21st century, it is hard to reconcile the concepts of the ‘Western’ diet and overconsumption with the risk of micronutrient deficiencies. However, deficiencies can arise from poor dietary intake, alone or combined with physiological or metabolic injury. Micronutrients are essential to fulfil a broad range of biochemical and physiological functions, and are tightly regulated by homeostatic processes. Diagnosis of deficiency is complex and requires the use of separate investigations (dietary, functional, biochemical). (Source: Medicine)
Source: Medicine - February 7, 2019 Category: Internal Medicine Authors: Emilie Combet, Christina Buckton Tags: Principles of human nutrition Source Type: research

Principles of human nutrition
We rely on the foods we eat to provide all the building blocks for tissue growth and reproduction, the energy required for all metabolism, functions and activities, and the compounds that are ‘essential’ for normal metabolism but cannot be synthesized by humans. Nutritional science covers all the processes involved in achieving a healthy balance between requirements and the supply of nutrients, at the right time and in appropriate proportions, at cellular, organ, whole-body and group /population levels. (Source: Medicine)
Source: Medicine - February 7, 2019 Category: Internal Medicine Authors: Michael EJ. Lean Tags: Principles of human nutrition Source Type: research

Artificial nutrition and nutrition support and refeeding syndrome
Both enteral and parenteral nutrition support should be managed by a multiprofessional team to ensure the correct choice and minimize complications. Enteral tube feeding is required for patients with a functioning gastrointestinal tract unable to meet their nutritional requirements orally, and can be either intragastric or post-pyloric. Naso-enteral tubes are preferred for short-term feeding ( (Source: Medicine)
Source: Medicine - February 4, 2019 Category: Internal Medicine Authors: T.E. Bowling, S.M. Gabe Tags: Undernutrition Source Type: research

Childhood obesity
is a serious global health problem. It begins early in life during the preschool years, and, for many, the obesity is carried forward into later childhood and adult life. Once established, obesity is difficult to reverse and is associated with poorer health outcomes in the short and long term. Tackling obesity in childhood is important to reduce life-long risk and protect health. However, service provision is lacking in the UK and other countries. Interventions that are successful in the prevention and management of childhood obesity are urgently needed. (Source: Medicine)
Source: Medicine - February 4, 2019 Category: Internal Medicine Authors: Julie Lanigan, Louise Tee, Rachael Brandreth Tags: Obesity Source Type: research

Pathophysiology and aetiology and medical consequences of obesity
The World Health Organization has classified obesity as an epidemic. Obesity (defined by body mass index) substantially increases a patient's lifetime risk of developing type 2 diabetes mellitus, as well as many other co-morbidities, including cancers and cardiovascular disease. Obesity is caused by multiple factors, which vary from patient to patient, but include obesogenic environment, genetics, medical, mental health and prescribed medications. Obesity appears to predispose patients to developing these multiple co-morbidities by interacting with metabolic and endocrinological processes, as well as exposing the body to i...
Source: Medicine - February 4, 2019 Category: Internal Medicine Authors: Adrian Park Tags: Obesity Source Type: research

Solitary rectal ulcer syndrome: A systematic review: Erratum
No abstract available (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Erratum Source Type: research

Electrical stimulation on adverse events caused by chemotherapy in patients with cervical cancer: A protocol for a systematic review of randomized controlled trial
Conclusion: The findings of this study may summarize the latest evidence for the ES on AEs following chemotherapy for CC. PROSPERO registration number: PROSPERO CRD42019120191. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Diagnostic value of using epicardial fat measurement on screening low-dose chest CT for the prediction of metabolic syndrome: A cross-validation study
There has been a marked increase in the use of low-dose computed tomography (LDCT) for lung cancer screening. However, the potential of LDCT to predict metabolic syndrome (MetS) has not been well-documented in this risk-sharing population. We assessed the reliability of epicardial fat volume (EFV) and epicardial fat area (EFA) measurements on chest LDCT for prediction of MetS. A total of 130 (mean age, 50.2 ± 10.77 years) asymptomatic male who underwent nonelectrocardiography (ECG)-gated LDCT were divided into 2 groups for the main analysis (n = 75) and validation (n = 55). Each group was further divide...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research

Fetal cardiac examination can affect patients’ preference on invasive tests: A new data on maternal anxiety indicated karyotyping
Conclusions: This is the first study evaluating the power of early fetal cardiac examination findings on fetal aneuploidies. This study suggested that the application of fetal cardiac examination findings to genetic counseling for screening aneuploidies may be efficient on patients’ preference about invasive tests. Due to the small number of abnormal findings and karyotypes detected (not the large study group), further studies on large study groups are needed to confirm these results. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

The telomere length of peripheral blood cells is associated with the risk of ischemic stroke in Han population of northern China
This study was to investigate the relationship between telomere length and the incidence of ischemic stroke in Han population of northern China. Methods: In the present study, 152 patients with ischemic stroke were selected as the case group, and 152 healthy persons were used as the control group. Detection of telomere length was done by real-time polymerase chain reaction after extraction of genomic DNA from peripheral venous blood. Results: Our results showed that the telomere length of the patients in the case group was significantly lower than that of the control group (Z = −11.843, P  (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study
Recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (RA), such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), could play a pathogenic role in insulin resistance and (IR) and type 2 diabetes (T2D). In this 6-month longitudinal study, we aimed at investigating if the inhibition of IL-1 or TNF is associated with an improvement of IR in RA patients with comorbid T2D and the possible effects on selected serum adipokines. RA patients with comorbid T2D were recruited among those undergoing treatment with anakinra (ANA) or with TNF inhibitor (TNFi). The 1998-updated ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Effects of traditional Chinese exercise on cognitive and psychological outcomes in older adults with mild cognitive impairment: A systematic review and meta-analysis
This study performs a meta-analysis to quantify the efficiency of TCE for older individuals on cognitive and psychological outcomes. Methods: A comprehensive database search was conducted on PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (EBSCO), Web of Science, and four Chinese medical databases. We included trials published up to April 22, 2018, that fulfilled our inclusion and exclusion criteria. The literature was screened, the data were extracted and the methodological quality of the included trials was assessed. Meta-analyses were performed on the included data. Results: A ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Assessment of the diagnostic value of using serum CA125 and GI-RADS system in the evaluation of adnexal masses
Cancer antigen 125 (CA125) is a valuable tumor marker for ovarian cancer. Gynecology Imaging Reporting and Data System (GI-RADS) is proved to be effective at identifying the adnexal masses. We investigated whether the combination of these two methods can improve the diagnostic accuracy of ovarian cancer. We retrospectively analyzed preoperative data of 325 patients diagnosed with suspected adnexal mass, 196 patients with benign ovarian masses and 129 with malignant ovarian cancer (stage I: 34, II: 16, III: 61, IV: 18). CA125 was analyzed using the ARCHITECT system, GI-RADS was evaluated according to the International Ovar...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research

Acupuncture for perimenopausal depressive disorder: A systematic review and meta-analysis protocol
Conclusion: This study provides evidence for evaluating the efficacy and safety of acupuncture in the treatment of PDD. PROSPERO registration number: CRD42018115811. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Surveillance of non-muscle invasive bladder cancer using fluorescence in situ hybridization: Protocol for a systematic review and meta-analysis
Conclusion: The diagnostic efficacy of FISH will be affected by post-therapy factors. However, FISH still could facilitate the surveillance of NMIBC owing to its non-invasive feature. This study will improve the clinical decision-making and enlighten the future research of NMIBC. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Randomized, open-label, multicenter study of azithromycin compared with doxycycline for treating anorectal Chlamydia trachomatis infection concomitant to a vaginal infection (CHLAZIDOXY study)
Discussion: The results of this trial will establish which treatment is more efficacious against anorectal infection and could affect recommendations for the treatment of urogenital C. trachomatis infection, taking into account concurrent anorectal infection. Trial registration numbers: EudraCT number: 2017-002595-15. ClinicalTrials.gov Identifier: NCT03532464. Date of registration: May 31, 2018. World Health Organisation International Clinical Trials Registry: NTC03532464. Secondary ID: CHUBX 2016/26. Date of registration: May 09, 2018. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

The effectiveness and safety of cervus and cucumis polypeptide injection in promoting fracture healing after bone fracture surgeries: Protocol for a systematic review and meta-analysis
Conclusion: Our study will use systematic evaluation to objectively evaluate the efficacy and safety of cervus and cucumis polypeptide injection in promoting fracture healing after fracture surgery. It will provide theoretical basis for guiding clinical practice and benefit more patients. Ethics and dissemination: This study is a systematic review that does not require ethical approval and meets the requirements of protocol for a systematic review and meta-analysis. At the same time, this study does not involve the recruitment of patients. All data are from published academic papers. Protocol and registration: A pr...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio
NLR/Alb (neutrophil lymphocyte ratio/albumin ratio), is a prognostic index for esophageal cancer has been confirmed. Prealbumin (PA) is more sensitive to malnutrition than albumin. A new prognostic index, named neutrophil lymphocyte ratio/prealbumin ratio (NLR/PA), for predicting the survival time in patients with esophageal squamous cell carcinoma (ESCC) was proposed. A retrospective study of 315 cases with ESCC was enrolled. The optimal cut-off values were evaluated by ROC curve (the receiver operating characteristics curve). Pearson correlation analyses were used to calculate the correlations among NLR, Alb, NLR/Alb an...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Pneumocystis jirovecii pneumonia as an initial manifestation of hyper-IgM syndrome in an infant: A case report
Rationale: Pneumocystis jirovecii causes severe pneumonia in immunocompromised hosts. Human immunodeficiency virus infection, malignancy, solid organ or hematopoietic cell transplantation, and primary immune deficiency compose the risk factors for Pneumocystis pneumonia (PCP) in children, and PCP can be an initial clinical manifestation of primary immune deficiency. Patient concerns: A 5-month-old infant presented with cyanosis and tachypnea. He had no previous medical or birth history suggesting primary immune deficiency. He was diagnosed with interstitial pneumonia on admission. Diagnoses: He was diagnosed with P...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report
Rationale: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion. Patient concerns: Here, we describe a patient with half-year fatigue and 40-day nausea and vomiting. Laboratory workup displayed increased serum creatinine, proteinuria, and...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

A novel computer navigation method for accurate percutaneous sacroiliac screw implantation: A technical note and literature review
The purpose of this study was to assess the accuracy of percutaneous sacroiliac screw (PSS) placement assisted by screw view model of navigation system for treatment of sacroiliac fractures. Data pertaining to 18 consecutive patients with posterior pelvic ring fracture who received sacroiliac screw fixation between January 2015 and July 2018 at the Second Hospital of Jilin University were retrospectively analyzed. Kirschner wires were placed under the guidance of navigation's screw view mode. The position of the screws was evaluated by computed tomography (CT) scan postoperatively. Fracture dislocation of sacroiliac joint...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Incidence of surgical-site infection following open reduction and internal fixation of a distal femur fracture: An observational case–control study
Surgical-site infection (SSI) is a common complication in orthopedic surgery; however, SSI after surgically managed distal femur fractures was not well studied. The aim of this study was to investigate the incidence of SSI and identify some modifiable and nonmodifiable risk factors. The patients’ electronic medical records (EMRs) were reviewed to identify those who sustained a distal femur fracture and treated by open reduction and internal fixation (ORIF) between March 2014 and February 2018. SSI was defined based on the Centers for Disease Control criteria and confirmed according to the descriptions in EMR. Univar...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Sarcopenia for predicting mortality among elderly nursing home residents: SARC-F versus SARC-CalF
Little is known about the prognostic value of the strength, assistance walking, rise from a chair, climb stairs, and falls questionnaire (SARC-F) and SARC-F combined with calf circumference (SARC-CalF) among elderly nursing home residents. To compare the prognostic value of SARC-F and SARC-CalF for mortality in this population. We conducted a prospective study in four nursing homes in western China. Sarcopenia was estimated using SARC-F and SARC-CalF, respectively. Nutrition status, activities of daily living, and other covariates were evaluated. The survival status was collected via medical records and telephone intervi...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Amiodarone and acupuncture for cardiac arrhythmia: Study protocol for a systematic review
Conclusion: The findings of this proposed study will summarize the up-to-date evidence of AA for CA. PROSPERO registration number: PROSPERO CRD42019120962. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Pharmacologic interventions for postoperative nausea and vomiting after thyroidectomy: A protocol for systematic review and network meta-analysis
Conclusion: This systematic review and NMA will provide a comprehensive and convincing evidence summary of prophylactic pharmacologic interventions for PONV after a thyroidectomy. Trial registration number: CRD42018100002. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Bloodletting therapy for treating patients with chronic urticaria: A systematic review and meta-analysis protocol
Background: Chronic urticaria is a common disease affecting patients’ quality of life, and leading to substantial burden to both patients and society. Many trials have shown that bloodletting therapy is effective in treating chronic urticaria. There are currently no systematic reviews of bloodletting therapy for chronic urticaria. This protocol aims to present the methods used to assess the effectiveness and safety of bloodletting therapy for patients with chronic urticaria. Methods: The following databases will be searched from their inception: the Cochrane Central Register of Controlled Trials (CENTRAL), PubMe...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Efficacy of tolvaptan for chronic heart failure: Study protocol for a systematic review of randomized controlled trial
Conclusion: The findings of this proposed study will summarize the current evidence of tolvaptan for CHF. Ethics and dissemination: All data used in this systematic review will be collected from the previous published trials. Thus, no research ethics approval is needed for this study. The findings of this study will be published at a peer-reviewed journal. PROSPERO registration number: PROSPERO CRD42019120818. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Patient-controlled intravenous analgesia with tramadol and lornoxicam after thoracotomy: A comparison with patient-controlled epidural analgesia
To determine efficacy and safety of patient-controlled intravenous analgesia (PCIA) with tramadol and lornoxicam for postoperative analgesia, and its effects on surgical outcomes in patients following thoracotomy. The records of patients who underwent thoracotomy for lung resection between January 2014 and December 2014 at our institution were reviewed. The patients were divided into 2 groups according to postoperative pain treatment modalities. Patients of the patient-controlled epidural analgesia (PCEA) group (n = 63), received PCEA with 0.2% ropivacaine plus 0.5 μg/mL sufentanil, while patients in the PCIA gro...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Local recurrence of sinonasal renal cell-like adenocarcinoma: A CARE compliant case report
Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it is necessary to differentiate SNRCLA from these tumors. Patient concerns: A 42-year-old man presented with complaints of epistaxis for 1 day. The patient had undergone endoscopic resection of a neoplasm in the right nasal passage at another hospital 35 months before and was diagnosed with SNRCLA at that time, and did not receive any other adjuvant therapy. Diagnoses: The postoperative ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Nephrocalcinosis in adolescent girl with medullary sponge kidney and mild hemihypertrophy: A case report
We present a case of 17-year old girl who was referred for metabolic evaluation of bilateral nephrocalcinosis. Physical examination showed signs of mild, left-sided hemihypertrophy involving the lower limb, buttock, trunk, face, and tongue. The imaging studies of kidneys including intravenous urography and contrast computed tomography showed numerous medullary calcification and a typical picture of MSK—“paint brush”/“bouquet of flowers” appearance of the dilated tubules within the renal medulla. Laboratory evaluation revealed sterile pyuria, hypercalciuria, and hypocitraturia. Intervention: ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Spontaneous regression of cervical discs: Retrospective analysis of 14 cases
Cervical disc herniation is a condition which arises from compression of cervical spinal nerve root by the degenerated disc and vast majority of the patients are aged between 30 and 40 years. Spontaneous regression of cervical disc was first reported by Kriegerand Maniker in 1992. Our study is the second large series in literature. Besides, 4 patients are the first who were shown to have resorption in C 4-5. The records of patients diagnosed with cervical disc herniation who applied to the Spine Polyclinic between 2014 and 2018 were reviewed retrospectively. The files of the patients who were recommended surgery with the ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Allogeneic blood transfusion in 163 children with acute lymphocytic leukemia (a STROBE-compliant article)
Little research has been done about the effects of allogeneic blood transfusion (ABT) on the recurrence and prognosis in the cases with childhood acute lymphocytic leukemia (cALL). In order to provide a basis for clinical safe blood transfusion, the data of 163 cases with cALL were retrospectively analyzed to explore the issue. The data of 163 cases with cALL between 2006 and 2011 were retrospectively analyzed. According to the frequency of blood transfusion, the 163 cases were divided into 4 groups including non-transfusion group, 1 to 10-time transfusion group, 11 to 25-time transfusion group, and>25-time transfusion...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Effect of extracorporeal shock wave for tennis elbow: A protocol for systematic review of randomized controlled trial
Conclusion: The findings of this study will summarize the current evidence of EPSW on TE outcomes and may provide guidance for both clinical practice and further studies. Dissemination and ethics: This systematic review does not need ethical approval, because it does not utilize the individual patient data. Its findings are expected to publish in peer-reviewed journals. Systematic review registration: PROSPERO CRD42019119687. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Biochip detection of BP180 autoantibodies in blister fluid for the serodiagnosis of bullous pemphigoid: A pilot study
This study investigated the use of a Biochip-based indirect immunofluorescence approach for the serum diagnosis of bullous pemphigoid on blister fluid. We compared the results using the Biochip-method with the ELISA detection of bullous pemphigoid-180 autoantibodies in blister fluid and observed a perfect correlation between these 2 methods in our group of 13 patients with clinical and direct immunofluorescence diagnosis of bullous pemphigoid. The Biochip is a simple, standardized and inexpensive diagnostic tool and its use on blister fluid may facilitate the diagnosis of this and other autoimmune bullous disorders. Our re...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome: A systematic review and meta-analysis
Conclusions: In terms of fecal SCFAs, there were differences between patients with IBS and HCs. In IBS-C patients, propionate and butyrate were reduced, whereas butyrate was increased in IBS-D patients in comparison to HCs. Propionate and butyrate could be used as biomarkers for IBS diagnosis. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Predictive factors of chemotherapy use in stage II nasopharyngeal carcinoma: A retrospective cohort study
Identification of predictive factors of chemotherapy use and assessment of the roles of these factors in prognosis will aid therapeutic decision-making in stage II nasopharyngeal carcinoma (NPC). Using logistic regression, we retrospectively assessed factors predicting chemotherapy use in 251 stage II (2010  UICC/AJCC staging system) NPC patients. Five-year overall survival (OS), locoregional-free survival (LRFS), and distant metastasis-free survival (DMFS) were analyzed based on the predictive factors. Logistic regression found that N1 stage was an independent factor predicting chemotherapy use in stage II NPC patient...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Effectiveness of extracorporeal shock wave for low back pain: A protocol of systematic review
Conclusion: The findings of this study may provide possible guidance for LBP treated by EPSW. Dissemination and ethics: Ethical approval is not required in this study, because it will not collect the original data from individual patient. The results are expected to publish through a peer-reviewed journal. Systematic review registration: PROSPERO CRD42019120501. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Efficacy of Duohuojisheng decoction monotherapy for the treatment of knee osteoarthritis: A protocol of a systematic review of randomized controlled trials
Conclusion: The results of this study provide latest updated evidence of DHJSD monotherapy alone for KOA. Ethics and dissemination: No ethical approval is required for this systematic review, because it is based on the published data, and not on individual patient data. Its findings is published in a peer-reviewed journal. PROSPERO registration number: PROSPERO CRD42019120405. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Effectiveness and safety of fire-needle moxibustion on insomnia: Protocol for a systematic review and meta-analysis
Conclusion: The conclusion of this study will provide evidence to judge the effectiveness and safety of Fire-needle moxibustion on insomnia. Registration: PROS-PERO CRD42019120875. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Clinical efficacy and safety of thread-embedding acupuncture for treatment of the sequelae of Bell's palsy: A protocol for a patient-assessor blinded, randomized, controlled, parallel clinical trial
Discussion: The results from this trial will help establish clinical evidence regarding the efficacy and safety of TEA in the treatment of patients with sequelae of Bell's palsy. Trial registration number: KCT0002557 (Clinical Research Information Service of the Republic of Korea). (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Association between smoking and serum uric acid in Korean population: Data from the seventh Korea national health and nutrition examination survey 2016
This study used a cross-sectional design and analyzed 5609 subjects aged ≥ 19 years among 8150 participants enrolled in the KNHANES VII-1 2016. Smoking status was classified into current smokers, never smokers, and ex-smokers. Hyperuricemia was defined as> 7.0 mg/dL for men and> 6.0 mg/dL of serum uric acid for women. Association between smoking and serum uric acid/hyperuricemia was assessed by Pearson's or Spearman's correlation analyses and multivariate logistic regression analysis showing odds ratio (OR) and 95% confidence interval (CI). A significant difference in serum uric acid according to smoking stat...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Effectiveness of extracorporeal shock-wave therapy for frozen shoulder: A protocol for a systematic review of randomized controlled trial
Conclusion: Its findings may provide latest evidence of ESWT for the treatment of frozen shoulder. Ethics and dissemination: No research ethics approval is required in this study, because it is a systematic review and will not use individual data. The results of this study are expected to publish at peer-reviewed journals. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Effect of Pro-kin visual feedback balance training system on gait stability in patients with cerebral small vessel disease
Due to the indistinct nature of symptoms for Cerebral Small Vessel Disease (CSVD), diagnosis is often missed. With significant deterioration of movement disorder, risk of falls increases dramatically. Comparison study was conducted to explore the association between balance function and gait instability, and the treatment effectiveness of visual feedback balance training on the gait disorder in CSVD patients. Fifty-six patients with CSVD were studied. They were randomly divided into observation and control groups, and were given conventional gait rehabilitation training, including single-leg weight, shift of the center o...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Impact of a home health care program for disabled patients in Taiwan: A nationwide population-based cohort study
The aim of this study was to evaluate the impact of home health care (HHC) for disabled patients. We conducted a nationwide population-based retrospective cohort study. A total of 5838 disabled patients with HHC were identified to match by propensity score with 15,829 disabled patients without HHC receiving tube or catheter care (tracheostomy tube, nasogastric tube, urinary catheter, cystostomy tube, nephrostomy tube) or stage 3 or 4 pressure sore care from the Taiwanese National Health Insurance Research Database between 2005 and 2009. After 1:1 matching, 2901 subjects in the HHC group and 2901 subjects in the non-HHC gr...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Anticoagulation in atrial fibrillation and cognitive decline: A systematic review and meta-analysis
Conclusion: Anticoagulation is associated with cognitive benefit in participants with AF independent of stroke and TIA, but it was not superior to antiplatelet drugs in reducing the risk of cognitive decline. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

The term “floating” used in traumatic orthopedics
Background: The term “floating” is used in orthopedic literature to describe certain patterns of skeletal injuries that share one common character which is disruption and discontinuity of bones above and below a joint. The first time used in orthopedic literature being in late 1970 to describe a type of elbow injury. Later the word was used increasingly and applied to a variety of injuries affecting the knee, shoulder, hip, forearm, hand, and ankle. Currently, there are about 12 different skeletal injuries described as floating. Objectives: The aim of this article was to define the term “floating&rdq...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Long-term efficacy of different procedures for treatment of varicose veins: A network meta-analysis
Conclusion: CHIVA seemed to have superior clinical benefits on long-term efficacy for treating varicose veins. However, the conclusion still needs additional trials for supporting evidence. (Source: Medicine)
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research