TREM2 protects against inflammation by regulating the release of mito-DAMPs from hepatocytes during liver fibrosis
CONCLUSION: Our study highlights that TREM2 serves as a negative regulator of liver fibrosis, suggesting its potential as a novel therapeutic target.PMID:38710340 | DOI:10.1016/j.freeradbiomed.2024.05.004 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 6, 2024 Category: Biology Authors: Shulin Shan Shihua Chao Zhidan Liu Shuai Wang Zhaoxiong Liu Cuiqin Zhang Dong Cheng Zhenhui Su Fuyong Song Source Type: research
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1
This study aimed to demonstrate that methyltransferase mediated hypermethylation was responsible for IVDD by integrative bioinformatics and experimental verification. Methyltransferase DNMT3B was highly expressed in severely degenerated NP tissue (involving human and rats) and in-vitro degenerated human NP cells (NPCs). Bioinformatics elucidated that hypermethylated genes were enriched in oxidative stress and ferroptosis, and the ferroptosis suppressor gene SLC40A1 was identified with lower expression and higher methylation in severely degenerated human NP tissue. Cell culture using human NPCs showed that DNMT3B induced fe...
Source: Free Radical Biology and Medicine - May 5, 2024 Category: Biology Authors: Jiaxing Chen Xinyu Yang Qiaochu Li Jingjin Ma Huanhuan Li Linbang Wang Zhiyu Chen Zhengxue Quan Source Type: research
Phloretin Prolongs Lifespan of Caenorhabditis elegans via Inhibition of NDUFS1 and NDUFS6 at Mitochondrial Complex Ⅰ
Free Radic Biol Med. 2024 May 3:S0891-5849(24)00434-9. doi: 10.1016/j.freeradbiomed.2024.05.005. Online ahead of print.ABSTRACTPhloretin has been widely perceived as an antioxidant. However, the bioavailability of phloretin in vivo is generally far too low to elicit a direct antioxidant effect by scavenging reactive oxygen species (ROS). Here we showed that administration of phloretin of apple polyphenols extended lifespan of Caenorhabditis elegans and promoted fitness. Specially phloretin enhanced the survival rates of nematodes under oxidants in an inverted U-shaped dose-response manner. The lifespan-extending effects of...
Source: Free Radical Biology and Medicine - May 5, 2024 Category: Biology Authors: Yu Zhang Yonglin Wu Bin Li Jing Tian Source Type: research
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1
This study aimed to demonstrate that methyltransferase mediated hypermethylation was responsible for IVDD by integrative bioinformatics and experimental verification. Methyltransferase DNMT3B was highly expressed in severely degenerated NP tissue (involving human and rats) and in-vitro degenerated human NP cells (NPCs). Bioinformatics elucidated that hypermethylated genes were enriched in oxidative stress and ferroptosis, and the ferroptosis suppressor gene SLC40A1 was identified with lower expression and higher methylation in severely degenerated human NP tissue. Cell culture using human NPCs showed that DNMT3B induced fe...
Source: Free Radical Biology and Medicine - May 5, 2024 Category: Biology Authors: Jiaxing Chen Xinyu Yang Qiaochu Li Jingjin Ma Huanhuan Li Linbang Wang Zhiyu Chen Zhengxue Quan Source Type: research
Phloretin Prolongs Lifespan of Caenorhabditis elegans via Inhibition of NDUFS1 and NDUFS6 at Mitochondrial Complex Ⅰ
Free Radic Biol Med. 2024 May 3:S0891-5849(24)00434-9. doi: 10.1016/j.freeradbiomed.2024.05.005. Online ahead of print.ABSTRACTPhloretin has been widely perceived as an antioxidant. However, the bioavailability of phloretin in vivo is generally far too low to elicit a direct antioxidant effect by scavenging reactive oxygen species (ROS). Here we showed that administration of phloretin of apple polyphenols extended lifespan of Caenorhabditis elegans and promoted fitness. Specially phloretin enhanced the survival rates of nematodes under oxidants in an inverted U-shaped dose-response manner. The lifespan-extending effects of...
Source: Free Radical Biology and Medicine - May 5, 2024 Category: Biology Authors: Yu Zhang Yonglin Wu Bin Li Jing Tian Source Type: research
Metallofullerenol alleviates alcoholic liver damage via ROS clearance under static magnetic and electric fields
Free Radic Biol Med. 2024 May 2:S0891-5849(24)00431-3. doi: 10.1016/j.freeradbiomed.2024.05.003. Online ahead of print.ABSTRACTAlcoholic liver disease (ALD) is a common chronic redox disease caused by increased alcohol consumption. Abstinence is a major challenge for people with alcohol dependence, and approved drugs have limited efficacy. Therefore, this study aimed to explore a new treatment strategy for ALD using ferroferric oxide endohedral fullerenol (Fe3O4@C60(OH)n) in combination with static magnetic and electric fields (sBE). The primary hepatocytes of 8-9-week-old female BALB/c mice were used to evaluate the effic...
Source: Free Radical Biology and Medicine - May 4, 2024 Category: Biology Authors: Haoyu Wang Junqi Zhao Shiliang Ji Tingjun Liu Zhisheng Chen Zhen Huang Yuhui Zang Jiangning Chen Junfeng Zhang Zhi Ding Source Type: research
Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway
In this study, we used a cecum ligation and puncture-induced lung injury mouse model and employed techniques including western blot, immunofluorescence, and enzyme-linked immunosorbent assay to measure the levels of NETs and other sepsis-related lung injury indicators. Our findings indicate that atorvastatin effectively inhibited the formation of NETs. When combined with imipenem, it significantly alleviated lung injury, reduced systemic inflammation, and improved the 7-day survival rate of septic mice. Additionally, we explored the inhibitory mechanism of atorvastatin on NET formation in vitro, revealing its potential act...
Source: Free Radical Biology and Medicine - May 4, 2024 Category: Biology Authors: Yue Zhang Di Wu Qishun Sun Zhen Luo Yuhao Zhang Bowei Wang Wenting Chen Source Type: research
Maternal selenium deficiency during pregnancy in association with autism and ADHD traits in children: the Odense Child Cohort
CONCLUSIONS: The results provide coherent evidence for selenium deficiency as a risk factor for ADHD and ASD traits in an environment with borderline supply, the causality of which should be elucidated in a randomized controlled trial.PMID:38704054 | DOI:10.1016/j.freeradbiomed.2024.05.001 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 4, 2024 Category: Biology Authors: Kamil Demircan Thilo Samson Chillon Richard Christian Jensen Tina Kold Jensen Qian Sun Steen Joop Bonnema Dorte Glintborg Niels Bilenberg Marianne Skovsager Andersen Lutz Schomburg Source Type: research
Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00427-1. doi: 10.1016/j.freeradbiomed.2024.04.240. Online ahead of print.ABSTRACTApart from dopaminergic neurotoxicity, exposure to rotenone, a commonly used insecticide in agriculture, also adversely affects hippocampal and cortical neurons, resulting in cognitive impairments in mice. We recently established a role of microglia-mediated neuroinflammation in rotenone-elicited deficits of cognition, yet the mechanisms remain elusive. Here, we investigated the involvement of NADPH oxidase 2 (NOX2) catalytic subunit gp91phox in rotenone-induced cognitive deficits and the associat...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Lu Tian Peiyan Tang Jianing Liu Yiyang Liu Liyan Hou Jie Zhao Qingshan Wang Source Type: research
Interplay between Hypoxia Inducible Factor-1 and mitochondria in cardiac diseases
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00426-X. doi: 10.1016/j.freeradbiomed.2024.04.239. Online ahead of print.ABSTRACTIschemic heart diseases and cardiomyopathies are characterized by hypoxia, energy starvation and mitochondrial dysfunction. HIF-1 acts as a cellular oxygen sensor, tuning the balance of metabolic and oxidative stress pathways to provide ATP and sustain cell survival. Acting on mitochondria, HIF-1 regulates different processes such as energy substrate utilization, oxidative phosphorylation and mitochondrial dynamics. In turn, mitochondrial homeostasis modifications impact HIF-1 activity. This under...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Jeanne Mialet-Perez Elise Belaidi Source Type: research
A Role of ROS-dependent Defects in Mitochondrial Dynamic and Autophagy in Carbon Black Nanoparticle-mediated Myocardial Cell Damage
This study explored the mechanisms of CBNPs-mediated myocardial toxicity. CBNPs were given to mice through intra-tracheal instillation and it was demonstrated that the particles can be taken up into the cardiac tissue. Exposure to CBNPs induced cardiomyocyte inflammation and apoptosis. In combination with in vitro experiments, we showed that CBNPs increased the ROS and induced mitochondria fragmentation. Functionally, CBNPs-exposed cardiomyocyte exhibited depolarization of the mitochondrial membrane potential, release of cytochrome c, and activation of pro-apoptotic BAX, thereby initiating programmed cell death. On the oth...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Zehua Xu Jing Li Bowen Su Hongying Gao Miaomiao Ren Yi Lin Heqing Shen Source Type: research
Terf2ip deficiency accelerates non-alcoholic steatohepatitis through regulating lipophagy and fatty acid oxidation via Sirt1/AMPK pathway
CONCLUSIONS: These results revealed that Terf2ip played a protective role in the progression of NASH through regulating lipophagy and FAO by binding to Sirt1 promoter. Our findings provided a potential therapeutic target for the treatment of NASH.PMID:38697492 | DOI:10.1016/j.freeradbiomed.2024.04.238 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Yirui Wang Shuochen Liu Ming Ni Yananlan Chen Ruixiang Chen Jifei Wang Wangjie Jiang Tao Zhou Shilong Fan Jiang Chang Xiao Xu Yaodong Zhang Yue Yu Xiangcheng Li Changxian Li Source Type: research
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma
In conclusion, our study uncovers the anticancer mechanism of agrimol B in HCC involving the regulation of oxidative stress and autophagy, and suggests agrimol B as a potential therapeutic drug for HCC treatment.PMID:38697493 | DOI:10.1016/j.freeradbiomed.2024.04.242 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Lixia Dong Li Luo Zihao Wang Shan Lian Mao Wang Xingyun Wu Jiawu Fan Yan Zeng Sijia Li Sinan Lv Yurong Yang Rong Chen Enhao Shen Wenyong Yang Changlong Li Kui Wang Source Type: research
Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00427-1. doi: 10.1016/j.freeradbiomed.2024.04.240. Online ahead of print.ABSTRACTApart from dopaminergic neurotoxicity, exposure to rotenone, a commonly used insecticide in agriculture, also adversely affects hippocampal and cortical neurons, resulting in cognitive impairments in mice. We recently established a role of microglia-mediated neuroinflammation in rotenone-elicited deficits of cognition, yet the mechanisms remain elusive. Here, we investigated the involvement of NADPH oxidase 2 (NOX2) catalytic subunit gp91phox in rotenone-induced cognitive deficits and the associat...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Lu Tian Peiyan Tang Jianing Liu Yiyang Liu Liyan Hou Jie Zhao Qingshan Wang Source Type: research
Interplay between Hypoxia Inducible Factor-1 and mitochondria in cardiac diseases
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00426-X. doi: 10.1016/j.freeradbiomed.2024.04.239. Online ahead of print.ABSTRACTIschemic heart diseases and cardiomyopathies are characterized by hypoxia, energy starvation and mitochondrial dysfunction. HIF-1 acts as a cellular oxygen sensor, tuning the balance of metabolic and oxidative stress pathways to provide ATP and sustain cell survival. Acting on mitochondria, HIF-1 regulates different processes such as energy substrate utilization, oxidative phosphorylation and mitochondrial dynamics. In turn, mitochondrial homeostasis modifications impact HIF-1 activity. This under...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Jeanne Mialet-Perez Elise Belaidi Source Type: research
