Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00383-6. doi: 10.1016/j.freeradbiomed.2024.04.212. Online ahead of print.ABSTRACTLamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac in...
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Vikas Tiwari Paras Gupta Navya Malladi Sanjay Salgar Sanjay K Banerjee Source Type: research
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
CONCLUSIONS: We describe a novel epigenetic mechanism wherein TET3 promoted ENPP1 expression through promoter hypomethylation is a critical mediator of NAFLD. Our findings provide new insight into the development of preventative measures for NAFLD.PMID:38582229 | DOI:10.1016/j.freeradbiomed.2024.04.207 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Feng Sun Yang Yang Lin Jia Qi-Qi Dong Wei Hu Hui Tao Chao Lu Jing-Jing Yang Source Type: research
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00383-6. doi: 10.1016/j.freeradbiomed.2024.04.212. Online ahead of print.ABSTRACTLamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac in...
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Vikas Tiwari Paras Gupta Navya Malladi Sanjay Salgar Sanjay K Banerjee Source Type: research
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
CONCLUSIONS: We describe a novel epigenetic mechanism wherein TET3 promoted ENPP1 expression through promoter hypomethylation is a critical mediator of NAFLD. Our findings provide new insight into the development of preventative measures for NAFLD.PMID:38582229 | DOI:10.1016/j.freeradbiomed.2024.04.207 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Feng Sun Yang Yang Lin Jia Qi-Qi Dong Wei Hu Hui Tao Chao Lu Jing-Jing Yang Source Type: research
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00373-3. doi: 10.1016/j.freeradbiomed.2024.04.208. Online ahead of print.ABSTRACTPeroxiredoxin 6 (Prdx6) repairs peroxidized membranes by reducing oxidized phospholipids, and by replacing oxidized sn-2 fatty acyl groups through hydrolysis/reacylation by its phospholipase A2 (aiPLA2) and lysophosphatidylcholine acyltransferase activities. Prdx6 is highly expressed in the lung, and intact lungs and cells null for Prdx6 or with single-point mutations that inactivate either Prdx6-peroxidase or aiPLA2 activity alone exhibit decreased viability, increased lipid peroxidation, and inco...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Julia Mar ía Torres-Velarde Kaitlin N Allen Andrea Salvador-Pascual Roberto G Leija Diamond Luong Diana Daniela Moreno-Santill án David C Ensminger Jos é Pablo Vázquez-Medina Source Type: research
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00161-8. doi: 10.1016/j.freeradbiomed.2024.03.024. Online ahead of print.ABSTRACTNon-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and mitophagy), which is under the central control of AMP-activated kinase (AMPK), in turn, determines mitochondrial quality. We have developed a NE-AMD model in C57BL/6J mice induc...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Hern án H Dieguez Horacio E Romeo Agustina Alaimo Nathaly A Bernal Aguirre Juan S Calanni Juan S Ad án Aréan Silvia Alvarez Roberta Sciurano Ruth E Rosenstein Dami án Dorfman Source Type: research
Corrigendum to "AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis" [Free Radic. Biol. Med. 129 (2018) 59-72]
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00138-2. doi: 10.1016/j.freeradbiomed.2024.03.013. Online ahead of print.NO ABSTRACTPMID:38580498 | DOI:10.1016/j.freeradbiomed.2024.03.013 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Dong Liu Zhiqiang Ma Shouyin Di Yang Yang Jingang Yang Liqun Xu Russel J Reiter Shubin Qiao Jiansong Yuan Source Type: research
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00373-3. doi: 10.1016/j.freeradbiomed.2024.04.208. Online ahead of print.ABSTRACTPeroxiredoxin 6 (Prdx6) repairs peroxidized membranes by reducing oxidized phospholipids, and by replacing oxidized sn-2 fatty acyl groups through hydrolysis/reacylation by its phospholipase A2 (aiPLA2) and lysophosphatidylcholine acyltransferase activities. Prdx6 is highly expressed in the lung, and intact lungs and cells null for Prdx6 or with single-point mutations that inactivate either Prdx6-peroxidase or aiPLA2 activity alone exhibit decreased viability, increased lipid peroxidation, and inco...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Julia Mar ía Torres-Velarde Kaitlin N Allen Andrea Salvador-Pascual Roberto G Leija Diamond Luong Diana Daniela Moreno-Santill án David C Ensminger Jos é Pablo Vázquez-Medina Source Type: research
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00161-8. doi: 10.1016/j.freeradbiomed.2024.03.024. Online ahead of print.ABSTRACTNon-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and mitophagy), which is under the central control of AMP-activated kinase (AMPK), in turn, determines mitochondrial quality. We have developed a NE-AMD model in C57BL/6J mice induc...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Hern án H Dieguez Horacio E Romeo Agustina Alaimo Nathaly A Bernal Aguirre Juan S Calanni Juan S Ad án Aréan Silvia Alvarez Roberta Sciurano Ruth E Rosenstein Dami án Dorfman Source Type: research
Corrigendum to "AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis" [Free Radic. Biol. Med. 129 (2018) 59-72]
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00138-2. doi: 10.1016/j.freeradbiomed.2024.03.013. Online ahead of print.NO ABSTRACTPMID:38580498 | DOI:10.1016/j.freeradbiomed.2024.03.013 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Dong Liu Zhiqiang Ma Shouyin Di Yang Yang Jingang Yang Liqun Xu Russel J Reiter Shubin Qiao Jiansong Yuan Source Type: research
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis
This study unraveled novel targets to revitalize the salivary secretion function in SS patients.PMID:38574973 | DOI:10.1016/j.freeradbiomed.2024.04.003 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Jiannan Zhou Janak L Pathak Lihong Wu Bo Chen Tingting Cao Wei Wei Xiaodan Wu Guiping Chen Nobumoto Watanabe Xiaomeng Li Jiang Li Source Type: research
Quantifying redox transcription factor dynamics as a tool to investigate redox signalling
Free Radic Biol Med. 2024 Apr 2;218:16-25. doi: 10.1016/j.freeradbiomed.2024.04.004. Online ahead of print.ABSTRACTA critical feature of the cellular antioxidant response is the induction of gene expression by redox-sensitive transcription factors. In many cells, activating these transcription factors is a dynamic process involving multiple redox steps, but it is unclear how these dynamics should be measured. Here, we show how the dynamic profile of the Schizosaccharomyces pombe Pap1 transcription factor is quantifiable by three parameters: signal amplitude, signal time and signal duration. In response to increasing hydrog...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Diane J Lind Kelisa C Naidoo Lewis E Tomalin Johann M Rohwer Elizabeth A Veal Ch é S Pillay Source Type: research
Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex
Free Radic Biol Med. 2024 Apr 2:S0891-5849(24)00170-9. doi: 10.1016/j.freeradbiomed.2024.04.005. Online ahead of print.ABSTRACTSarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the pro...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Alexandra Moreira-Pais Rui Vitorino Cl áudia Sousa-Mendes Maria Jo ão Neuparth Alessandro Nuccio Claudio Luparello Alessandro Attanzio Petr Nov ák Dmitry Loginov Rita Nogueira-Ferreira Adelino Leite-Moreira Paula A Oliveira Rita Ferreira Jos é A Duart Source Type: research
Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor
Free Radic Biol Med. 2024 Apr 2:S0891-5849(24)00165-5. doi: 10.1016/j.freeradbiomed.2024.03.028. Online ahead of print.ABSTRACTUnderstanding the tumor redox status is important for efficient cancer treatment. Here, we noninvasively detected changes in the redox environment of tumors before and after cancer treatment in the same individuals using a novel compact and portable electron paramagnetic resonance imaging (EPRI) device and compared the results with glycolytic information obtained through autoradiography using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG). Human colon cancer HCT116 xenografts were used in the mice. We ...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Kazuhiro Kato Hironobu Yasui Hideo Sato-Akaba Miho C Emoto Hirotada G Fujii Maciej M Kmiec Periannan Kuppusamy Yuki Mizuno Yuji Kuge Masaki Nagane Tadashi Yamashita Osamu Inanami Source Type: research
Targeting NKA α1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis
In conclusion, this study establishes NKAα1 as a key regulator of ferroptosis and mitophagy, identifying its DR-region as a promising therapeutic target for PD.PMID:38574977 | DOI:10.1016/j.freeradbiomed.2024.04.002 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Xiaoyan Zhang Guanghong Li Hanbin Chen Xiao-Wei Nie Jin-Song Bian Source Type: research
