mtDNA regulates cGAS-STING signaling pathway in adenomyosis
Free Radic Biol Med. 2024 Mar 15:S0891-5849(24)00137-0. doi: 10.1016/j.freeradbiomed.2024.03.012. Online ahead of print.ABSTRACTIn various hyperproliferative disorders, damaged mitochondria can release mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING signaling pathway and subsequent immune imbalances. Our previous research has demonstrated that hypoxia plays a role in the development of adenomyosis (AM) by inducing mitochondrial dysfunction. However, the precise involvement of the cGAS-STING signaling pathway and mtDNA in AM remains unclear. Therefore, this study aims to investigate the relationship ...
Source: Free Radical Biology and Medicine - March 17, 2024 Category: Biology Authors: Kun Wang Yi Wen Xianyun Fu Shaobin Wei Shidan Liu Minmin Chen Source Type: research
TIGAR reduces neuronal ferroptosis by inhibiting succinate dehydrogenase activity in cerebral ischemia
In conclusion, mitochondrial translocation of TIGAR in prolonged ischemia is an important pathway to reduce neuronal ferroptosis and provide sustainable antioxidant defense for the brain under prolonged ischemia, further complementing the mechanism of TIGAR resistance to oxidative stress induced by IS.PMID:38494143 | DOI:10.1016/j.freeradbiomed.2024.03.011 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 17, 2024 Category: Biology Authors: Xinxin Wang Mei Li Fan Wang Guanghui Mao Junchao Wu Rong Han Rui Sheng Zhenghong Qin Hong Ni Source Type: research
Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?
Free Radic Biol Med. 2024 Mar 14:S0891-5849(24)00135-7. doi: 10.1016/j.freeradbiomed.2024.03.009. Online ahead of print.ABSTRACTWe propose that the diet-derived compound ergothioneine (ET) is an important nutrient in the human body, especially for maintenance of normal brain function, and that low body ET levels predispose humans to significantly increased risks of neurodegenerative (cognitive impairment, dementia, Parkinson's disease) and possibly other age-related diseases (including frailty, cardiovascular disease, and eye disease). Hence, restoring ET levels in the body could assist in mitigating these risks, which are...
Source: Free Radical Biology and Medicine - March 16, 2024 Category: Biology Authors: Barry Halliwell Irwin Cheah Source Type: research
Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?
Free Radic Biol Med. 2024 Mar 14:S0891-5849(24)00135-7. doi: 10.1016/j.freeradbiomed.2024.03.009. Online ahead of print.ABSTRACTWe propose that the diet-derived compound ergothioneine (ET) is an important nutrient in the human body, especially for maintenance of normal brain function, and that low body ET levels predispose humans to significantly increased risks of neurodegenerative (cognitive impairment, dementia, Parkinson's disease) and possibly other age-related diseases (including frailty, cardiovascular disease, and eye disease). Hence, restoring ET levels in the body could assist in mitigating these risks, which are...
Source: Free Radical Biology and Medicine - March 16, 2024 Category: Biology Authors: Barry Halliwell Irwin Cheah Source Type: research
Redox organization of living systems
Free Radic Biol Med. 2024 Mar 13:S0891-5849(24)00134-5. doi: 10.1016/j.freeradbiomed.2024.03.008. Online ahead of print.ABSTRACTRedox organization governs an underlying simplicity in living systems. Critically, redox reactions enable the essential characteristics of life: extraction of energy from the environment, use of energy to support metabolic and structural organization, use of dynamic redox responses to defend against environmental threats, and use of redox mechanisms to direct differentiation of cells and organ systems essential for reproduction. These processes are sustained through a redox context in which electr...
Source: Free Radical Biology and Medicine - March 15, 2024 Category: Biology Authors: Dean P Jones Source Type: research
Corrigendum to "Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials" [Free Radic. Biol. Med. (2024) 215 25-36]
Free Radic Biol Med. 2024 Mar 13;216:23. doi: 10.1016/j.freeradbiomed.2024.03.002. Online ahead of print.NO ABSTRACTPMID:38484453 | DOI:10.1016/j.freeradbiomed.2024.03.002 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 14, 2024 Category: Biology Authors: Cicero Jonas R Benjamim Leonardo S Lopes da Silva Vitor E Valenti Leonardo S Gon çalves Andrey A Porto M árcio Fernando Tasinafo Júnior Jean-Philippe Walhin David M Garner Bruno Gualano Carlos R Bueno J únior Source Type: research
Corrigendum to "Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials" [Free Radic. Biol. Med. (2024) 215 25-36]
Free Radic Biol Med. 2024 Mar 13;216:23. doi: 10.1016/j.freeradbiomed.2024.03.002. Online ahead of print.NO ABSTRACTPMID:38484453 | DOI:10.1016/j.freeradbiomed.2024.03.002 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 14, 2024 Category: Biology Authors: Cicero Jonas R Benjamim Leonardo S Lopes da Silva Vitor E Valenti Leonardo S Gon çalves Andrey A Porto M árcio Fernando Tasinafo Júnior Jean-Philippe Walhin David M Garner Bruno Gualano Carlos R Bueno J únior Source Type: research
Changed regulation of granulocyte NADPH oxidase activity in the mouse model of obesity-induced type 2 diabetes mellitus
Free Radic Biol Med. 2024 Mar 11;216:33-45. doi: 10.1016/j.freeradbiomed.2024.03.006. Online ahead of print.ABSTRACTNADPH oxidase is a target of hyperglycemia in type 2 diabetes mellitus (T2DM), which causes dysregulation of enzyme. Alterations in regulation of NADPH oxidase activity mediated receptor and non-receptor signaling in bone marrow granulocytes of mice with obesity-induced T2DM were studied. The animals fed high fat diet (516 kcal/100 g) for 16 weeks. NADPH oxidase-related generation of reactive species (RS) at normo- and hyperthermia was estimated using chemiluminescent analysis. The redox status of the cells w...
Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Irina V Tikhonova Alsu R Dyukina Andrei A Grinevich Elvira R Shaykhutdinova Valentina G Safronova Source Type: research
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta
In conclusion, our research demonstrates that H2S plays a pivotal role in regulating S-sulfhydration of TRAF7 at Cys327. This regulation effectively inhibits the ubiquitin-mediated degradation of KLF4, resulting in an upregulation of VE-cadherin levels. This molecular mechanism contributes to the prevention of endothelial barrier damage.PMID:38479633 | DOI:10.1016/j.freeradbiomed.2024.02.024 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Qianzhu Li Jiaxin Kang Ning Liu Jiayi Huang Xueya Zhang Kemiao Pang Shiwu Zhang Mengyi Wang Yajun Zhao Shiyun Dong Hongxia Li Dechao Zhao Fanghao Lu Weihua Zhang Source Type: research
Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation
Free Radic Biol Med. 2024 Mar 11:S0891-5849(24)00114-X. doi: 10.1016/j.freeradbiomed.2024.02.023. Online ahead of print.ABSTRACTParkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. Cordycepin is known to exhibit antitumor, anti-inflammatory, antioxidative stress, and neuroprotective effects; however, few studies have explored the neuroprotective mechanism of cordycepin in PD. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we investigated the impact of cordycepin on PD and its underlying molecular mechanisms. The findings indicated that cordycep...
Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Linhai Wang Shu Tian Sisi Ruan Jingjing Wei Sijia Wei Weiwei Chen Hangcui Hu Weiwei Qin Yan Li Hang Yuan Jian Mao Yan Xu Jianping Xie Source Type: research
Changed regulation of granulocyte NADPH oxidase activity in the mouse model of obesity-induced type 2 diabetes mellitus
Free Radic Biol Med. 2024 Mar 11:S0891-5849(24)00125-4. doi: 10.1016/j.freeradbiomed.2024.03.006. Online ahead of print.ABSTRACTNADPH oxidase is a target of hyperglycemia in type 2 diabetes mellitus (T2DM), which causes dysregulation of enzyme. Alterations in regulation of NADPH oxidase activity mediated receptor and non-receptor signaling in bone marrow granulocytes of mice with obesity-induced T2DM were studied. The animals fed high fat diet (516 kcal/100 g) for 16 weeks. NADPH oxidase-related generation of reactive species (RS) at normo- and hyperthermia was estimated using chemiluminescent analysis. The redox status of...
Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Irina V Tikhonova Alsu R Dyukina Andrei A Grinevich Elvira R Shaykhutdinova Valentina G Safronova Source Type: research
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta
In conclusion, our research demonstrates that H2S plays a pivotal role in regulating S-sulfhydration of TRAF7 at Cys327. This regulation effectively inhibits the ubiquitin-mediated degradation of KLF4, resulting in an upregulation of VE-cadherin levels. This molecular mechanism contributes to the prevention of endothelial barrier damage.PMID:38479633 | DOI:10.1016/j.freeradbiomed.2024.02.024 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Qianzhu Li Jiaxin Kang Ning Liu Jiayi Huang Xueya Zhang Kemiao Pang Shiwu Zhang Mengyi Wang Yajun Zhao Shiyun Dong Hongxia Li Dechao Zhao Fanghao Lu Weihua Zhang Source Type: research
Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation
Free Radic Biol Med. 2024 Mar 11:S0891-5849(24)00114-X. doi: 10.1016/j.freeradbiomed.2024.02.023. Online ahead of print.ABSTRACTParkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. Cordycepin is known to exhibit antitumor, anti-inflammatory, antioxidative stress, and neuroprotective effects; however, few studies have explored the neuroprotective mechanism of cordycepin in PD. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we investigated the impact of cordycepin on PD and its underlying molecular mechanisms. The findings indicated that cordycep...
Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Linhai Wang Shu Tian Sisi Ruan Jingjing Wei Sijia Wei Weiwei Chen Hangcui Hu Weiwei Qin Yan Li Hang Yuan Jian Mao Yan Xu Jianping Xie Source Type: research
The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E < sup > -/- < /sup > mice
Free Radic Biol Med. 2024 Mar 8:S0891-5849(24)00120-5. doi: 10.1016/j.freeradbiomed.2024.03.001. Online ahead of print.ABSTRACTOxidized low density lipoprotein (oxLDL)-induced endothelial oxidative damage promotes the development of atherosclerosis. Caveolae play an essential role in maintaining the survival and function of vascular endothelial cell (VEC). It is reported that the long coiled-coil protein NECC2 is localized in caveolae and is associated with neural cell differentiation and adipocyte formation, but its role in VECs needs to be clarified. Our results showed NECC2 expression increased in the endothelium of pla...
Source: Free Radical Biology and Medicine - March 10, 2024 Category: Biology Authors: Xin Mu Shu-Jun Liu Lei-Yin Zheng Chenxi Ouyang Ahmed M E Abdalla Xin-Xin Wang Kai Chen Fei-Fei Yang Ning Meng Source Type: research
The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E < sup > -/- < /sup > mice
Free Radic Biol Med. 2024 Mar 8:S0891-5849(24)00120-5. doi: 10.1016/j.freeradbiomed.2024.03.001. Online ahead of print.ABSTRACTOxidized low density lipoprotein (oxLDL)-induced endothelial oxidative damage promotes the development of atherosclerosis. Caveolae play an essential role in maintaining the survival and function of vascular endothelial cell (VEC). It is reported that the long coiled-coil protein NECC2 is localized in caveolae and is associated with neural cell differentiation and adipocyte formation, but its role in VECs needs to be clarified. Our results showed NECC2 expression increased in the endothelium of pla...
Source: Free Radical Biology and Medicine - March 10, 2024 Category: Biology Authors: Xin Mu Shu-Jun Liu Lei-Yin Zheng Chenxi Ouyang Ahmed M E Abdalla Xin-Xin Wang Kai Chen Fei-Fei Yang Ning Meng Source Type: research
