Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis
This study unraveled novel targets to revitalize the salivary secretion function in SS patients.PMID:38574973 | DOI:10.1016/j.freeradbiomed.2024.04.003 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Jiannan Zhou Janak L Pathak Lihong Wu Bo Chen Tingting Cao Wei Wei Xiaodan Wu Guiping Chen Nobumoto Watanabe Xiaomeng Li Jiang Li Source Type: research
Quantifying redox transcription factor dynamics as a tool to investigate redox signalling
Free Radic Biol Med. 2024 Apr 2;218:16-25. doi: 10.1016/j.freeradbiomed.2024.04.004. Online ahead of print.ABSTRACTA critical feature of the cellular antioxidant response is the induction of gene expression by redox-sensitive transcription factors. In many cells, activating these transcription factors is a dynamic process involving multiple redox steps, but it is unclear how these dynamics should be measured. Here, we show how the dynamic profile of the Schizosaccharomyces pombe Pap1 transcription factor is quantifiable by three parameters: signal amplitude, signal time and signal duration. In response to increasing hydrog...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Diane J Lind Kelisa C Naidoo Lewis E Tomalin Johann M Rohwer Elizabeth A Veal Ch é S Pillay Source Type: research
Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex
Free Radic Biol Med. 2024 Apr 2:S0891-5849(24)00170-9. doi: 10.1016/j.freeradbiomed.2024.04.005. Online ahead of print.ABSTRACTSarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the pro...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Alexandra Moreira-Pais Rui Vitorino Cl áudia Sousa-Mendes Maria Jo ão Neuparth Alessandro Nuccio Claudio Luparello Alessandro Attanzio Petr Nov ák Dmitry Loginov Rita Nogueira-Ferreira Adelino Leite-Moreira Paula A Oliveira Rita Ferreira Jos é A Duart Source Type: research
Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor
Free Radic Biol Med. 2024 Apr 2:S0891-5849(24)00165-5. doi: 10.1016/j.freeradbiomed.2024.03.028. Online ahead of print.ABSTRACTUnderstanding the tumor redox status is important for efficient cancer treatment. Here, we noninvasively detected changes in the redox environment of tumors before and after cancer treatment in the same individuals using a novel compact and portable electron paramagnetic resonance imaging (EPRI) device and compared the results with glycolytic information obtained through autoradiography using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG). Human colon cancer HCT116 xenografts were used in the mice. We ...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Kazuhiro Kato Hironobu Yasui Hideo Sato-Akaba Miho C Emoto Hirotada G Fujii Maciej M Kmiec Periannan Kuppusamy Yuki Mizuno Yuji Kuge Masaki Nagane Tadashi Yamashita Osamu Inanami Source Type: research
Targeting NKA α1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis
In conclusion, this study establishes NKAα1 as a key regulator of ferroptosis and mitophagy, identifying its DR-region as a promising therapeutic target for PD.PMID:38574977 | DOI:10.1016/j.freeradbiomed.2024.04.002 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Xiaoyan Zhang Guanghong Li Hanbin Chen Xiao-Wei Nie Jin-Song Bian Source Type: research
Muscle strength, quantity and quality and muscle fat quantity and their association with oxidative stress in patients with facioscapulohumeral muscular dystrophy: Effect of antioxidant supplementation
Free Radic Biol Med. 2024 Apr 2:S0891-5849(24)00166-7. doi: 10.1016/j.freeradbiomed.2024.04.001. Online ahead of print.ABSTRACTThe purpose of this study was to identify causes of quadriceps muscle weakness in facioscapulohumeral muscular dystrophy (FSHD). To this aim, we evaluated quadriceps muscle and fat volumes by magnetic resonance imaging and their relationships with muscle strength and oxidative stress markers in adult patients with FSHD (n = 32) and healthy controls (n = 7), and the effect of antioxidant supplementation in 20 of the 32 patients with FSHD (n = 10 supplementation and n = 10 placebo) (NCT01596803). Com...
Source: Free Radical Biology and Medicine - April 4, 2024 Category: Biology Authors: Vinicius Dias Wilson S ébastien Bommart Emilie Passerieux Claire Thomas Jo ël Pincemail Marie Christine Picot Jacques Mercier Florence Portet Sandrine Arbogast Dalila Laoudj-Chenivesse Source Type: research
Mapping the interplay of immunoproteasome and autophagy in different heart failure phenotypes
Free Radic Biol Med. 2024 Apr 1:S0891-5849(24)00163-1. doi: 10.1016/j.freeradbiomed.2024.03.026. Online ahead of print.ABSTRACTProper protein degradation is required for cellular protein homeostasis and organ function. Particularly, in post-mitotic cells, such as cardiomyocytes, unbalanced proteolysis due to inflammatory stimuli and oxidative stress contributes to organ dysfunction. To ensure appropriate protein turnover, eukaryotic cells exert two main degradation systems, the ubiquitin-proteasome-system and the autophagy-lysosome-pathway. It has been shown that proteasome activity affects the development of cardiac dysfu...
Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Christiane Ott Source Type: research
Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system
In conclusion, our findings first provided new evidence for GA as an inducer of ferroptosis, and Nrf2-mediated GSH/Trx dual antioxidant system played an important role in GA-induced ferroptosis.PMID:38570172 | DOI:10.1016/j.freeradbiomed.2024.03.023 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Jinshuai Lan Li Liu Wenjun Zhao Zhe Li Ruifeng Zeng Shiyuan Fang Lixia Chen Yi Shen Hai Wei Tong Zhang Yue Ding Source Type: research
Mapping the interplay of immunoproteasome and autophagy in different heart failure phenotypes
Free Radic Biol Med. 2024 Apr 1:S0891-5849(24)00163-1. doi: 10.1016/j.freeradbiomed.2024.03.026. Online ahead of print.ABSTRACTProper protein degradation is required for cellular protein homeostasis and organ function. Particularly, in post-mitotic cells, such as cardiomyocytes, unbalanced proteolysis due to inflammatory stimuli and oxidative stress contributes to organ dysfunction. To ensure appropriate protein turnover, eukaryotic cells exert two main degradation systems, the ubiquitin-proteasome-system and the autophagy-lysosome-pathway. It has been shown that proteasome activity affects the development of cardiac dysfu...
Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Christiane Ott Source Type: research
Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system
In conclusion, our findings first provided new evidence for GA as an inducer of ferroptosis, and Nrf2-mediated GSH/Trx dual antioxidant system played an important role in GA-induced ferroptosis.PMID:38570172 | DOI:10.1016/j.freeradbiomed.2024.03.023 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Jinshuai Lan Li Liu Wenjun Zhao Zhe Li Ruifeng Zeng Shiyuan Fang Lixia Chen Yi Shen Hai Wei Tong Zhang Yue Ding Source Type: research
FRBM Mini REVIEW: Chemogenetic approaches to probe redox dysregulation in heart failure
Free Radic Biol Med. 2024 Mar 31;217:173-178. doi: 10.1016/j.freeradbiomed.2024.03.027. Online ahead of print.ABSTRACTChemogenetics refers to experimental methods that use novel recombinant proteins that can be dynamically and uniquely regulated by specific biochemicals. Chemogenetic approaches allow the precise manipulation of cellular signaling to delineate the molecular pathways involved in both physiological and pathological disease states. Approaches utilizing yeast d-amino acid oxidase (DAAO) enable manipulation of intracellular redox metabolism through generation of hydrogen peroxide in the presence of d-amino acids...
Source: Free Radical Biology and Medicine - April 2, 2024 Category: Biology Authors: Ruby Guo Fotios Spyropoulos Thomas Michel Source Type: research
From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases
Free Radic Biol Med. 2024 Mar 31:S0891-5849(24)00162-X. doi: 10.1016/j.freeradbiomed.2024.03.025. Online ahead of print.ABSTRACTBeyond their crucial role in energy production, mitochondria harbor a distinct genome subject to epigenetic regulation akin to that of nuclear DNA. This paper delves into the nascent but rapidly evolving fields of mitoepigenetics and mitoepigenomics, exploring the sophisticated regulatory mechanisms governing mitochondrial DNA (mtDNA). These mechanisms encompass mtDNA methylation, the influence of non-coding RNAs (ncRNAs), and post-translational modifications of mitochondrial proteins. Together, t...
Source: Free Radical Biology and Medicine - April 2, 2024 Category: Biology Authors: Luigi Donato Domenico Mord à Concetta Scimone Simona Alibrandi Rosalia D'Angelo Antonina Sidoti Source Type: research
FRBM Mini REVIEW: Chemogenetic approaches to probe redox dysregulation in heart failure
Free Radic Biol Med. 2024 Mar 31:S0891-5849(24)00164-3. doi: 10.1016/j.freeradbiomed.2024.03.027. Online ahead of print.ABSTRACTChemogenetics refers to experimental methods that use novel recombinant proteins that can be dynamically and uniquely regulated by specific biochemicals. Chemogenetic approaches allow the precise manipulation of cellular signaling to delineate the molecular pathways involved in both physiological and pathological disease states. Approaches utilizing yeast d-amino acid oxidase (DAAO) enable manipulation of intracellular redox metabolism through generation of hydrogen peroxide in the presence of d-a...
Source: Free Radical Biology and Medicine - April 2, 2024 Category: Biology Authors: Ruby Guo Fotios Spyropoulos Thomas Michel Source Type: research
From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases
Free Radic Biol Med. 2024 Mar 31:S0891-5849(24)00162-X. doi: 10.1016/j.freeradbiomed.2024.03.025. Online ahead of print.ABSTRACTBeyond their crucial role in energy production, mitochondria harbor a distinct genome subject to epigenetic regulation akin to that of nuclear DNA. This paper delves into the nascent but rapidly evolving fields of mitoepigenetics and mitoepigenomics, exploring the sophisticated regulatory mechanisms governing mitochondrial DNA (mtDNA). These mechanisms encompass mtDNA methylation, the influence of non-coding RNAs (ncRNAs), and post-translational modifications of mitochondrial proteins. Together, t...
Source: Free Radical Biology and Medicine - April 2, 2024 Category: Biology Authors: Luigi Donato Domenico Mord à Concetta Scimone Simona Alibrandi Rosalia D'Angelo Antonina Sidoti Source Type: research
Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism
This study provides new ideas for clarifying the intrinsic mechanism of neuronal damage after I/R.PMID:38556067 | DOI:10.1016/j.freeradbiomed.2024.03.020 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 31, 2024 Category: Biology Authors: Zijie Wang Shaoru Zhang Ruiqi Cheng Anan Jiang Xinyue Qin Source Type: research
