Chronic exposure to PM < sub > 10 < /sub > induces anxiety-like behavior via exacerbating hippocampal oxidative stress
Free Radic Biol Med. 2024 Mar 6:S0891-5849(24)00115-1. doi: 10.1016/j.freeradbiomed.2024.02.025. Online ahead of print.ABSTRACTAs one of the most environmental concerns, inhaled particulate matter (PM10) causes numerous health problems. However, the associations between anxiety behavior and toxicity caused by PM10 have rarely been reported so far. To investigate the changes of behavior after PM10 exposure and to identify the potential mechanisms of toxicity, PM10 samples (with doses of 15 mg/kg and 30 mg/kg) were intratracheally instilled into rats to simulate inhalation of polluted air by the lungs. After instillation for...
Source: Free Radical Biology and Medicine - March 8, 2024 Category: Biology Authors: Jie Cheng Jian Sun Rui Niu Xiaoqing Wang Guilin Hu Fan Li Kunrong Gu Hao Wu Yuanchun Pu Fanqi Shen Hao Hu Zhenxing Shen Source Type: research
Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum
In conclusion, this proteomic analysis reveals a striking breadth of cellular processes affected by lysine acetylation and provides new nodes of intervention in the biosynthesis of secondary metabolites in G. lucidum.PMID:38458391 | DOI:10.1016/j.freeradbiomed.2024.02.029 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 8, 2024 Category: Biology Authors: Jing Han Lingshuai Wang Xin Tang Rui Liu Liang Shi Jing Zhu Mingwen Zhao Source Type: research
Unveiling the antioxidant superiority of α-tocopherol: Implications for vitamin E nomenclature and classification
In this study, we aim to elucidate the unique characteristics of α-tocopherol from a chemical perspective. Utilizing density functional theory (DFT) calculations, we evaluated the thermodynamic and kinetic properties of tocopherols, tocotrienols and their oxidation products. Our findings highlight the superior thermodynamic and kinetic properties of α-tocopherol. Although tocopherol substrates generally exhibit similar reactivities, α-tocopherol is distinguished by a larger gap between the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) in intermediates, indicating a potential fo...
Source: Free Radical Biology and Medicine - March 8, 2024 Category: Biology Authors: Hao Tian Yi-Fang Li Genlong Jiao Wan-Yang Sun Rong-Rong He Source Type: research
Chronic exposure to PM < sub > 10 < /sub > induces anxiety-like behavior via exacerbating hippocampal oxidative stress
Free Radic Biol Med. 2024 Mar 6:S0891-5849(24)00115-1. doi: 10.1016/j.freeradbiomed.2024.02.025. Online ahead of print.ABSTRACTAs one of the most environmental concerns, inhaled particulate matter (PM10) causes numerous health problems. However, the associations between anxiety behavior and toxicity caused by PM10 have rarely been reported so far. To investigate the changes of behavior after PM10 exposure and to identify the potential mechanisms of toxicity, PM10 samples (with doses of 15 mg/kg and 30 mg/kg) were intratracheally instilled into rats to simulate inhalation of polluted air by the lungs. After instillation for...
Source: Free Radical Biology and Medicine - March 8, 2024 Category: Biology Authors: Jie Cheng Jian Sun Rui Niu Xiaoqing Wang Guilin Hu Fan Li Kunrong Gu Hao Wu Yuanchun Pu Fanqi Shen Hao Hu Zhenxing Shen Source Type: research
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation
CONCLUSION: Hydrogen exerts neuroprotective effects by inhibiting neuronal ferroptosis and attenuating neuroinflammation after SAH.PMID:38447853 | DOI:10.1016/j.freeradbiomed.2024.02.028 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 6, 2024 Category: Biology Authors: Zheng Peng Xiao-Jian Li Yan Zhou Jia-Tong Zhang Qi Zhu Jia-Qing Sun Chun-Hua Hang Wei Li Qing-Rong Zhang Zong Zhuang Source Type: research
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation
CONCLUSION: Hydrogen exerts neuroprotective effects by inhibiting neuronal ferroptosis and attenuating neuroinflammation after SAH.PMID:38447853 | DOI:10.1016/j.freeradbiomed.2024.02.028 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 6, 2024 Category: Biology Authors: Zheng Peng Xiao-Jian Li Yan Zhou Jia-Tong Zhang Qi Zhu Jia-Qing Sun Chun-Hua Hang Wei Li Qing-Rong Zhang Zong Zhuang Source Type: research
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation
CONCLUSION: Hydrogen exerts neuroprotective effects by inhibiting neuronal ferroptosis and attenuating neuroinflammation after SAH.PMID:38447853 | DOI:10.1016/j.freeradbiomed.2024.02.028 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 6, 2024 Category: Biology Authors: Zheng Peng Xiao-Jian Li Yan Zhou Jia-Tong Zhang Qi Zhu Jia-Qing Sun Chun-Hua Hang Wei Li Qing-Rong Zhang Zong Zhuang Source Type: research
Cardiac Resolvin D2 ameliorates sepsis-induced cardiomyopathy via inhibiting Caspase-11/GSDMD dependent pyroptosis
CONCLUSION: These findings suggest that decreased cardiac RvD2 may involve in the pathogenesis of SICM. In addition, treatment with RvD2 represents a novel therapeutic strategy for SICM by inhibiting cardiomyocytes pyroptosis.PMID:38437927 | DOI:10.1016/j.freeradbiomed.2024.02.026 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 4, 2024 Category: Biology Authors: Wen-Wu Zhang Shun-Shun Wang Yang-Dong Ding Xin-Yi Wu Jin-Ling Wei Ye Gao Sheng-Wei Jin Pu-Hong Zhang Source Type: research
Cardiac Resolvin D2 ameliorates sepsis-induced cardiomyopathy via inhibiting Caspase-11/GSDMD dependent pyroptosis
CONCLUSION: These findings suggest that decreased cardiac RvD2 may involve in the pathogenesis of SICM. In addition, treatment with RvD2 represents a novel therapeutic strategy for SICM by inhibiting cardiomyocytes pyroptosis.PMID:38437927 | DOI:10.1016/j.freeradbiomed.2024.02.026 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 4, 2024 Category: Biology Authors: Wen-Wu Zhang Shun-Shun Wang Yang-Dong Ding Xin-Yi Wu Jin-Ling Wei Ye Gao Sheng-Wei Jin Pu-Hong Zhang Source Type: research
Overexpression of cat2 restores antioxidant properties and production traits in degenerated strains of Volvariella volvacea
This study provides a new biotechnological strategy to control the degeneration of V. volvacea and other edible fungi.PMID:38432262 | DOI:10.1016/j.freeradbiomed.2024.02.027 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 3, 2024 Category: Biology Authors: Jianing Zhu Wenpei Wang Wanhe Sun Yuanxi Lei Qiangfei Tan Gahong Zhao Jianmin Yun Fengyun Zhao Source Type: research
Overexpression of cat2 restores antioxidant properties and production traits in degenerated strains of Volvariella volvacea
This study provides a new biotechnological strategy to control the degeneration of V. volvacea and other edible fungi.PMID:38432262 | DOI:10.1016/j.freeradbiomed.2024.02.027 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 3, 2024 Category: Biology Authors: Jianing Zhu Wenpei Wang Wanhe Sun Yuanxi Lei Qiangfei Tan Gahong Zhao Jianmin Yun Fengyun Zhao Source Type: research
Revising the nomenclature for vitamin E requires agreement on its vitamin function
Free Radic Biol Med. 2024 Feb 29:S0891-5849(24)00110-2. doi: 10.1016/j.freeradbiomed.2024.02.022. Online ahead of print.NO ABSTRACTPMID:38431239 | DOI:10.1016/j.freeradbiomed.2024.02.022 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - March 2, 2024 Category: Biology Authors: Alexander Montoya-Arroyo Jan Frank Source Type: research
Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study
Free Radic Biol Med. 2024 Feb 26:S0891-5849(24)00109-6. doi: 10.1016/j.freeradbiomed.2024.02.021. Online ahead of print.ABSTRACTCarrying an allele 4 of the apolipoprotein E (ApoE) is the best-established genetic risk factor to develop Alzheimer's disease (AD). Fifty percent of ApoE4/4 individuals develop the disease at 70 years of age. ApoE3/4 carriers have a lower risk of developing the disease, still 50% of them suffer AD at around 80 years. In a previous study we showed that healthy young individuals, who had a parent with AD and were carriers of at least one ApoE4 allele displayed reductive stress. This was evidenced a...
Source: Free Radical Biology and Medicine - February 28, 2024 Category: Biology Authors: Mariana Nepomuceno Paloma Monllor Maria Jose Cardells Artemis Ftara Maria Magallon Francisco Das í Mari Carmen Badia Jose Vi ña Ana Lloret Source Type: research
Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study
Free Radic Biol Med. 2024 Feb 26:S0891-5849(24)00109-6. doi: 10.1016/j.freeradbiomed.2024.02.021. Online ahead of print.ABSTRACTCarrying an allele 4 of the apolipoprotein E (ApoE) is the best-established genetic risk factor to develop Alzheimer's disease (AD). Fifty percent of ApoE4/4 individuals develop the disease at 70 years of age. ApoE3/4 carriers have a lower risk of developing the disease, still 50% of them suffer AD at around 80 years. In a previous study we showed that healthy young individuals, who had a parent with AD and were carriers of at least one ApoE4 allele displayed reductive stress. This was evidenced a...
Source: Free Radical Biology and Medicine - February 28, 2024 Category: Biology Authors: Mariana Nepomuceno Paloma Monllor Maria Jose Cardells Artemis Ftara Maria Magallon Francisco Das í Mari Carmen Badia Jose Vi ña Ana Lloret Source Type: research
Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study
Free Radic Biol Med. 2024 Feb 26:S0891-5849(24)00109-6. doi: 10.1016/j.freeradbiomed.2024.02.021. Online ahead of print.ABSTRACTCarrying an allele 4 of the apolipoprotein E (ApoE) is the best-established genetic risk factor to develop Alzheimer's disease (AD). Fifty percent of ApoE4/4 individuals develop the disease at 70 years of age. ApoE3/4 carriers have a lower risk of developing the disease, still 50% of them suffer AD at around 80 years. In a previous study we showed that healthy young individuals, who had a parent with AD and were carriers of at least one ApoE4 allele displayed reductive stress. This was evidenced a...
Source: Free Radical Biology and Medicine - February 28, 2024 Category: Biology Authors: Mariana Nepomuceno Paloma Monllor Maria Jose Cardells Artemis Ftara Maria Magallon Francisco Das í Mari Carmen Badia Jose Vi ña Ana Lloret Source Type: research
