Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-cov-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study
CONCLUSIONS: KTR show suboptimal serological responses to SARS-CoV-2 vaccination, which is inversely associated with serum R-SH, reflecting systemic oxidative stress. Albeit this association was not robust to relevant confounding factors, it may at least partially be involved in the inability of KTR to generate a positive serological response after SARS-CoV-2 vaccination.PMID:38395091 | DOI:10.1016/j.freeradbiomed.2024.02.018 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 23, 2024 Category: Biology Authors: Larissa E van Eijk Arno R Bourgonje A Lianne Messchendorp Marian L C Bulthuis Marjan Reinders-Luinge Berber Doornbos-van der Meer Johanna Westra Wilfred F A den Dunnen Jan-Luuk Hillebrands Jan-Stephan F Sanders Harry van Goor RECOVAC Collaborators Source Type: research
Aging hallmarks, biomarkers, and clocks for personalized medicine: (re)positioning the limelight
Free Radic Biol Med. 2024 Feb 21:S0891-5849(24)00092-3. doi: 10.1016/j.freeradbiomed.2024.02.012. Online ahead of print.ABSTRACTThe rapidly increasing aging prevalence, complexity, and heterogeneity pose the scientific and medical communities in front of challenges. These are delivered by gaps between basic and translational research, as well as between clinical practice guidelines to improve survival and absence of evidence on personalized strategies to improve functions, wellbeing and quality of life. The triumphs of aging science sheding more and more light on mechanisms of aging as well as those of medical and technolo...
Source: Free Radical Biology and Medicine - February 23, 2024 Category: Biology Authors: M Cristina Polidori Source Type: research
Therapeutic effect of mitochondrial transplantation on burn injury
In conclusion, our data indicate that MT exerts a therapeutic effect on burn injuries both in vitro and in vivo.PMID:38395090 | DOI:10.1016/j.freeradbiomed.2024.02.019 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 23, 2024 Category: Biology Authors: Zhen Li Xinhui Cao Zuohao Liu Fen Wu Changjun Lin Chun-Ming Wang Source Type: research
Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-cov-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study
CONCLUSIONS: KTR show suboptimal serological responses to SARS-CoV-2 vaccination, which is inversely associated with serum R-SH, reflecting systemic oxidative stress. Albeit this association was not robust to relevant confounding factors, it may at least partially be involved in the inability of KTR to generate a positive serological response after SARS-CoV-2 vaccination.PMID:38395091 | DOI:10.1016/j.freeradbiomed.2024.02.018 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 23, 2024 Category: Biology Authors: Larissa E van Eijk Arno R Bourgonje A Lianne Messchendorp Marian L C Bulthuis Marjan Reinders-Luinge Berber Doornbos-van der Meer Johanna Westra Wilfred F A den Dunnen Jan-Luuk Hillebrands Jan-Stephan F Sanders Harry van Goor RECOVAC Collaborators Source Type: research
Corrigendum to "Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss" [Free Radic. Biol. Med. 210 (2024) 430-447]
Free Radic Biol Med. 2024 Feb 17;214:114. doi: 10.1016/j.freeradbiomed.2024.01.040. Online ahead of print.NO ABSTRACTPMID:38368776 | DOI:10.1016/j.freeradbiomed.2024.01.040 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Yaqi Liao Huanyu Mao Xian Gao Hailiang Lin Wenyan Li Yan Chen Huawei Li Source Type: research
Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction
Free Radic Biol Med. 2024 Feb 17;214:193-205. doi: 10.1016/j.freeradbiomed.2024.02.006. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a widespread metabolic disease presenting with various complications, including spermatogenic dysfunction. However, the underlying mechanisms are still unclear. Ferroptosis, a novel type of programmed cell death, is associated with much metabolic diseases. Here, we investigated the role of ferroptosis in spermatogenic dysfunction of streptozotocin (STZ)-induced type 1 diabetic mice (diabetic mice), high glucose (HG)-treated GC-2 cells (HG cells) as well as testicular tissues of dia...
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Yalei Cao Zirun Jin Yu Xi Jianxing Cheng Zishui Fang Qiancheng Zhao Jiaming Weng Jun Zhu Yanlin Tang Zhe Zhang Hui Jiang Source Type: research
Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure
In this study, benzoylaconitine inhibited Ang II-induced cell hypertrophy and fibrosis in rat primary cardiomyocytes and rat fibroblasts, while attenuating cardiac function and cardiac remodeling in TAC mice. Using the limited proteolysis-mass spectrometry (LiP-MS) method, the angiotensin-converting enzyme 2 (ACE2) was confirmed as a direct binding target of benzoylaconitine for the treatment of heart failure. In ACE2-knockdown cells and ACE2-/- mice, benzoylaconitine failed to ameliorate cardiomyocyte hypertrophy, fibrosis, and heart failure. Online RNA-sequence analysis indicated p38/ERK-mediated mitochondrial reactive o...
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Qi-Qiang Zhang Qing-Shan Chen Fei Feng Xiang Cao Xiao-Fei Chen Hai Zhang Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Corrigendum to "Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss" [Free Radic. Biol. Med. 210 (2024) 430-447]
Free Radic Biol Med. 2024 Feb 17;214:114. doi: 10.1016/j.freeradbiomed.2024.01.040. Online ahead of print.NO ABSTRACTPMID:38368776 | DOI:10.1016/j.freeradbiomed.2024.01.040 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Yaqi Liao Huanyu Mao Xian Gao Hailiang Lin Wenyan Li Yan Chen Huawei Li Source Type: research
Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction
Free Radic Biol Med. 2024 Feb 17;214:193-205. doi: 10.1016/j.freeradbiomed.2024.02.006. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a widespread metabolic disease presenting with various complications, including spermatogenic dysfunction. However, the underlying mechanisms are still unclear. Ferroptosis, a novel type of programmed cell death, is associated with much metabolic diseases. Here, we investigated the role of ferroptosis in spermatogenic dysfunction of streptozotocin (STZ)-induced type 1 diabetic mice (diabetic mice), high glucose (HG)-treated GC-2 cells (HG cells) as well as testicular tissues of dia...
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Yalei Cao Zirun Jin Yu Xi Jianxing Cheng Zishui Fang Qiancheng Zhao Jiaming Weng Jun Zhu Yanlin Tang Zhe Zhang Hui Jiang Source Type: research
Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure
In this study, benzoylaconitine inhibited Ang II-induced cell hypertrophy and fibrosis in rat primary cardiomyocytes and rat fibroblasts, while attenuating cardiac function and cardiac remodeling in TAC mice. Using the limited proteolysis-mass spectrometry (LiP-MS) method, the angiotensin-converting enzyme 2 (ACE2) was confirmed as a direct binding target of benzoylaconitine for the treatment of heart failure. In ACE2-knockdown cells and ACE2-/- mice, benzoylaconitine failed to ameliorate cardiomyocyte hypertrophy, fibrosis, and heart failure. Online RNA-sequence analysis indicated p38/ERK-mediated mitochondrial reactive o...
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Qi-Qiang Zhang Qing-Shan Chen Fei Feng Xiang Cao Xiao-Fei Chen Hai Zhang Source Type: research
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice
CONCLUSIONS: These results suggest that a single neonatal exposure to anesthesia/surgery causes impairment of memory, but not learning, in young adult mice through IL-6-regulated increases in NR2B concentrations in medial prefrontal cortex, highlighting the need for further research on the underlying mechanisms of anesthesia/surgery's impact on cognitive function in developing brains.PMID:38369077 | DOI:10.1016/j.freeradbiomed.2024.02.017 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Songhua Zhou Xiaoyu Cui Jie Chen Manli Luo Wen Ouyang Jianbin Tong Zhongcong Xie Yuan Le Source Type: research
Corrigendum to "Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss" [Free Radic. Biol. Med. 210 (2024) 430-447]
Free Radic Biol Med. 2024 Feb 17;214:114. doi: 10.1016/j.freeradbiomed.2024.01.040. Online ahead of print.NO ABSTRACTPMID:38368776 | DOI:10.1016/j.freeradbiomed.2024.01.040 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Yaqi Liao Huanyu Mao Xian Gao Hailiang Lin Wenyan Li Yan Chen Huawei Li Source Type: research
Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction
Free Radic Biol Med. 2024 Feb 16:S0891-5849(24)00080-7. doi: 10.1016/j.freeradbiomed.2024.02.006. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a widespread metabolic disease presenting with various complications, including spermatogenic dysfunction. However, the underlying mechanisms are still unclear. Ferroptosis, a novel type of programmed cell death, is associated with much metabolic diseases. Here, we investigated the role of ferroptosis in spermatogenic dysfunction of streptozotocin (STZ)-induced type 1 diabetic mice (diabetic mice), high glucose (HG)-treated GC-2 cells (HG cells) as well as testicular tiss...
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Yalei Cao Zirun Jin Yu Xi Jianxing Cheng Zishui Fang Qiancheng Zhao Jiaming Weng Jun Zhu Yanlin Tang Zhe Zhang Hui Jiang Source Type: research
Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure
In this study, benzoylaconitine inhibited Ang II-induced cell hypertrophy and fibrosis in rat primary cardiomyocytes and rat fibroblasts, while attenuating cardiac function and cardiac remodeling in TAC mice. Using the limited proteolysis-mass spectrometry (LiP-MS) method, the angiotensin-converting enzyme 2 (ACE2) was confirmed as a direct binding target of benzoylaconitine for the treatment of heart failure. In ACE2-knockdown cells and ACE2-/- mice, benzoylaconitine failed to ameliorate cardiomyocyte hypertrophy, fibrosis, and heart failure. Online RNA-sequence analysis indicated p38/ERK-mediated mitochondrial reactive o...
Source: Free Radical Biology and Medicine - February 18, 2024 Category: Biology Authors: Qi-Qiang Zhang Qing-Shan Chen Fei Feng Xiang Cao Xiao-Fei Chen Hai Zhang Source Type: research
