Effect of a personalized intensive dietary intervention on Base Excision Repair (BER) in colorectal cancer patients: Results from a randomized controlled trial
In conclusion, the results do not support an effect of dietary intervention on BER activity in post-surgery CRC patients during a 6-month intervention period.PMID:38588903 | DOI:10.1016/j.freeradbiomed.2024.04.211 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 8, 2024 Category: Biology Authors: Anne Lene Nordengen Congying Zheng Annika Krutto Ane S Kv ærner Dena T Alavi Hege B Henriksen Christine Henriksen Sigbj ørn Smeland Siv K B øhn Ingvild Paur Sergey Shaposhnikov Andrew R Collins Rune Blomhoff Source Type: research
Effect of a personalized intensive dietary intervention on Base Excision Repair (BER) in colorectal cancer patients: Results from a randomized controlled trial
In conclusion, the results do not support an effect of dietary intervention on BER activity in post-surgery CRC patients during a 6-month intervention period.PMID:38588903 | DOI:10.1016/j.freeradbiomed.2024.04.211 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 8, 2024 Category: Biology Authors: Anne Lene Nordengen Congying Zheng Annika Krutto Ane S Kv ærner Dena T Alavi Hege B Henriksen Christine Henriksen Sigbj ørn Smeland Siv K B øhn Ingvild Paur Sergey Shaposhnikov Andrew R Collins Rune Blomhoff Source Type: research
Effect of a personalized intensive dietary intervention on Base Excision Repair (BER) in colorectal cancer patients: Results from a randomized controlled trial
In conclusion, the results do not support an effect of dietary intervention on BER activity in post-surgery CRC patients during a 6-month intervention period.PMID:38588903 | DOI:10.1016/j.freeradbiomed.2024.04.211 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 8, 2024 Category: Biology Authors: Anne Lene Nordengen Congying Zheng Annika Krutto Ane S Kv ærner Dena T Alavi Hege B Henriksen Christine Henriksen Sigbj ørn Smeland Siv K B øhn Ingvild Paur Sergey Shaposhnikov Andrew R Collins Rune Blomhoff Source Type: research
Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury
This study investigated the mechanism by which lipid droplets (LDs) degraded via autophagy (lipophagy)required for RAB7 regulated ferroptosis in the pathogenesis of S-AKI. Here, we constructed the S-AKI model in vitro and in vivo to elucidate the potential relationship of lipophagy and ferroptosis, and we first confirmed that the activation of lipophagy promoted renal tubular epithelial cell ferroptosis and renal damage in S-AKI. The results showed that lipopolysaccharide (LPS) induced a marked increase in lipid peroxidation and ferroptosis, which were rescued by ferrstain-1 (Fer-1), an inhibitor of ferroptosis. In additio...
Source: Free Radical Biology and Medicine - April 7, 2024 Category: Biology Authors: Yuanting Yang Qisheng Lin Xuying Zhu Xinghua Shao Shu Li Jialin Li Jingkui Wu Haijiao Jin Chaojun Qi Na Jiang Kaiqi Zhang Qin Wang Leyi Gu Zhaohui Ni Source Type: research
Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury
This study investigated the mechanism by which lipid droplets (LDs) degraded via autophagy (lipophagy)required for RAB7 regulated ferroptosis in the pathogenesis of S-AKI. Here, we constructed the S-AKI model in vitro and in vivo to elucidate the potential relationship of lipophagy and ferroptosis, and we first confirmed that the activation of lipophagy promoted renal tubular epithelial cell ferroptosis and renal damage in S-AKI. The results showed that lipopolysaccharide (LPS) induced a marked increase in lipid peroxidation and ferroptosis, which were rescued by ferrstain-1 (Fer-1), an inhibitor of ferroptosis. In additio...
Source: Free Radical Biology and Medicine - April 7, 2024 Category: Biology Authors: Yuanting Yang Qisheng Lin Xuying Zhu Xinghua Shao Shu Li Jialin Li Jingkui Wu Haijiao Jin Chaojun Qi Na Jiang Kaiqi Zhang Qin Wang Leyi Gu Zhaohui Ni Source Type: research
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00383-6. doi: 10.1016/j.freeradbiomed.2024.04.212. Online ahead of print.ABSTRACTLamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac in...
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Vikas Tiwari Paras Gupta Navya Malladi Sanjay Salgar Sanjay K Banerjee Source Type: research
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
CONCLUSIONS: We describe a novel epigenetic mechanism wherein TET3 promoted ENPP1 expression through promoter hypomethylation is a critical mediator of NAFLD. Our findings provide new insight into the development of preventative measures for NAFLD.PMID:38582229 | DOI:10.1016/j.freeradbiomed.2024.04.207 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Feng Sun Yang Yang Lin Jia Qi-Qi Dong Wei Hu Hui Tao Chao Lu Jing-Jing Yang Source Type: research
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00383-6. doi: 10.1016/j.freeradbiomed.2024.04.212. Online ahead of print.ABSTRACTLamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac in...
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Vikas Tiwari Paras Gupta Navya Malladi Sanjay Salgar Sanjay K Banerjee Source Type: research
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
CONCLUSIONS: We describe a novel epigenetic mechanism wherein TET3 promoted ENPP1 expression through promoter hypomethylation is a critical mediator of NAFLD. Our findings provide new insight into the development of preventative measures for NAFLD.PMID:38582229 | DOI:10.1016/j.freeradbiomed.2024.04.207 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Feng Sun Yang Yang Lin Jia Qi-Qi Dong Wei Hu Hui Tao Chao Lu Jing-Jing Yang Source Type: research
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00373-3. doi: 10.1016/j.freeradbiomed.2024.04.208. Online ahead of print.ABSTRACTPeroxiredoxin 6 (Prdx6) repairs peroxidized membranes by reducing oxidized phospholipids, and by replacing oxidized sn-2 fatty acyl groups through hydrolysis/reacylation by its phospholipase A2 (aiPLA2) and lysophosphatidylcholine acyltransferase activities. Prdx6 is highly expressed in the lung, and intact lungs and cells null for Prdx6 or with single-point mutations that inactivate either Prdx6-peroxidase or aiPLA2 activity alone exhibit decreased viability, increased lipid peroxidation, and inco...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Julia Mar ía Torres-Velarde Kaitlin N Allen Andrea Salvador-Pascual Roberto G Leija Diamond Luong Diana Daniela Moreno-Santill án David C Ensminger Jos é Pablo Vázquez-Medina Source Type: research
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00161-8. doi: 10.1016/j.freeradbiomed.2024.03.024. Online ahead of print.ABSTRACTNon-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and mitophagy), which is under the central control of AMP-activated kinase (AMPK), in turn, determines mitochondrial quality. We have developed a NE-AMD model in C57BL/6J mice induc...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Hern án H Dieguez Horacio E Romeo Agustina Alaimo Nathaly A Bernal Aguirre Juan S Calanni Juan S Ad án Aréan Silvia Alvarez Roberta Sciurano Ruth E Rosenstein Dami án Dorfman Source Type: research
Corrigendum to "AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis" [Free Radic. Biol. Med. 129 (2018) 59-72]
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00138-2. doi: 10.1016/j.freeradbiomed.2024.03.013. Online ahead of print.NO ABSTRACTPMID:38580498 | DOI:10.1016/j.freeradbiomed.2024.03.013 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Dong Liu Zhiqiang Ma Shouyin Di Yang Yang Jingang Yang Liqun Xu Russel J Reiter Shubin Qiao Jiansong Yuan Source Type: research
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00373-3. doi: 10.1016/j.freeradbiomed.2024.04.208. Online ahead of print.ABSTRACTPeroxiredoxin 6 (Prdx6) repairs peroxidized membranes by reducing oxidized phospholipids, and by replacing oxidized sn-2 fatty acyl groups through hydrolysis/reacylation by its phospholipase A2 (aiPLA2) and lysophosphatidylcholine acyltransferase activities. Prdx6 is highly expressed in the lung, and intact lungs and cells null for Prdx6 or with single-point mutations that inactivate either Prdx6-peroxidase or aiPLA2 activity alone exhibit decreased viability, increased lipid peroxidation, and inco...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Julia Mar ía Torres-Velarde Kaitlin N Allen Andrea Salvador-Pascual Roberto G Leija Diamond Luong Diana Daniela Moreno-Santill án David C Ensminger Jos é Pablo Vázquez-Medina Source Type: research
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00161-8. doi: 10.1016/j.freeradbiomed.2024.03.024. Online ahead of print.ABSTRACTNon-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and mitophagy), which is under the central control of AMP-activated kinase (AMPK), in turn, determines mitochondrial quality. We have developed a NE-AMD model in C57BL/6J mice induc...
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Hern án H Dieguez Horacio E Romeo Agustina Alaimo Nathaly A Bernal Aguirre Juan S Calanni Juan S Ad án Aréan Silvia Alvarez Roberta Sciurano Ruth E Rosenstein Dami án Dorfman Source Type: research
Corrigendum to "AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis" [Free Radic. Biol. Med. 129 (2018) 59-72]
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00138-2. doi: 10.1016/j.freeradbiomed.2024.03.013. Online ahead of print.NO ABSTRACTPMID:38580498 | DOI:10.1016/j.freeradbiomed.2024.03.013 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 5, 2024 Category: Biology Authors: Dong Liu Zhiqiang Ma Shouyin Di Yang Yang Jingang Yang Liqun Xu Russel J Reiter Shubin Qiao Jiansong Yuan Source Type: research
