Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation
In conclusion, our findings indicate that isorhamnetin could protect against cisplatin-induced acute kidney injury by inducing PGC-1α-dependent reprogramming of fatty acid oxidation, which highlights the clinical potential of isorhamnetin as a therapeutic approach for the management of cisplatin-induced nephrotoxicity.PMID:38101584 | DOI:10.1016/j.freeradbiomed.2023.12.010 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Lingkun Wang Yaochen Xie Boneng Xiao Xuelin He Guanghui Ying Huiyan Zha Chen Yang Xuejin Jin Guilin Li Li Ping Jincheng Wang Qinjie Weng Source Type: research
Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides
Free Radic Biol Med. 2023 Dec 13:S0891-5849(23)01156-5. doi: 10.1016/j.freeradbiomed.2023.12.011. Online ahead of print.ABSTRACTCholesterol is an essential component of cell membranes and serves as an important precursor of steroidal hormones and bile acids, but elevated levels of cholesterol and its oxidation products have been accepted as a risk factor for maintenance of health. The free and ester forms of cholesterol and fatty acids are the two major biological lipids. The aim of this hypothesis paper is to address the long-standing dogma that cholesterol is less susceptible to free radical peroxidation than polyunsatur...
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Yoshiro Saito Noriko Noguchi Etsuo Niki Source Type: research
Sestrin2 inhibits RANKL-induced osteoclastogenesis through AMPK activation and ROS inhibition
This study investigated the effects of Sestrin2 (Sesn2) on osteoclast differentiation and function. Overexpressing Sesn2 in osteoclast precursor cells significantly inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis. This was assessed as reduced expression of various osteoclast markers, including c-Fos, nuclear factor of activated T cells 1 (NFATc1), osteoclast-associated receptor, tartrate-resistant acid phosphatase, and cathepsin K. Conversely, downregulation of Sesn2 produced the opposite effect. Mechanistically, Sesn2 overexpression enhanced AMPK activation and the nuclear tran...
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Kabsun Kim Jung Ha Kim Inyoung Kim Semun Seong Jeong-Tae Koh Nacksung Kim Source Type: research
Mitochondrial transplantation attenuates oligomeric amyloid-beta-induced mitochondrial dysfunction and tight junction protein destruction in retinal pigment epithelium
Free Radic Biol Med. 2023 Dec 13:S0891-5849(23)01157-7. doi: 10.1016/j.freeradbiomed.2023.12.012. Online ahead of print.ABSTRACTTransplantation of mitochondria derived from mesenchymal stem cells (MSCs) has emerged as a new treatment method to improve mitochondrial dysfunction and alleviate cell impairment. Interest in using extrinsic mitochondrial transplantation as a therapeutic approach has been increasing because it has been confirmed to be effective in treating various diseases related to mitochondrial dysfunction, including ischemia, cardiovascular disease, and toxic damage. To support this application, we conducted ...
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Sung-Eun Noh Seok Jae Lee Chang Sik Cho Dong Hyun Jo Kyu Sang Park Jeong Hun Kim Source Type: research
Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation
In conclusion, our findings indicate that isorhamnetin could protect against cisplatin-induced acute kidney injury by inducing PGC-1α-dependent reprogramming of fatty acid oxidation, which highlights the clinical potential of isorhamnetin as a therapeutic approach for the management of cisplatin-induced nephrotoxicity.PMID:38101584 | DOI:10.1016/j.freeradbiomed.2023.12.010 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Lingkun Wang Yaochen Xie Boneng Xiao Xuelin He Guanghui Ying Huiyan Zha Chen Yang Xuejin Jin Guilin Li Li Ping Jincheng Wang Qinjie Weng Source Type: research
Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides
Free Radic Biol Med. 2023 Dec 13:S0891-5849(23)01156-5. doi: 10.1016/j.freeradbiomed.2023.12.011. Online ahead of print.ABSTRACTCholesterol is an essential component of cell membranes and serves as an important precursor of steroidal hormones and bile acids, but elevated levels of cholesterol and its oxidation products have been accepted as a risk factor for maintenance of health. The free and ester forms of cholesterol and fatty acids are the two major biological lipids. The aim of this hypothesis paper is to address the long-standing dogma that cholesterol is less susceptible to free radical peroxidation than polyunsatur...
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Yoshiro Saito Noriko Noguchi Etsuo Niki Source Type: research
Sestrin2 inhibits RANKL-induced osteoclastogenesis through AMPK activation and ROS inhibition
This study investigated the effects of Sestrin2 (Sesn2) on osteoclast differentiation and function. Overexpressing Sesn2 in osteoclast precursor cells significantly inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis. This was assessed as reduced expression of various osteoclast markers, including c-Fos, nuclear factor of activated T cells 1 (NFATc1), osteoclast-associated receptor, tartrate-resistant acid phosphatase, and cathepsin K. Conversely, downregulation of Sesn2 produced the opposite effect. Mechanistically, Sesn2 overexpression enhanced AMPK activation and the nuclear tran...
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Kabsun Kim Jung Ha Kim Inyoung Kim Semun Seong Jeong-Tae Koh Nacksung Kim Source Type: research
Mitochondrial transplantation attenuates oligomeric amyloid-beta-induced mitochondrial dysfunction and tight junction protein destruction in retinal pigment epithelium
Free Radic Biol Med. 2023 Dec 13:S0891-5849(23)01157-7. doi: 10.1016/j.freeradbiomed.2023.12.012. Online ahead of print.ABSTRACTTransplantation of mitochondria derived from mesenchymal stem cells (MSCs) has emerged as a new treatment method to improve mitochondrial dysfunction and alleviate cell impairment. Interest in using extrinsic mitochondrial transplantation as a therapeutic approach has been increasing because it has been confirmed to be effective in treating various diseases related to mitochondrial dysfunction, including ischemia, cardiovascular disease, and toxic damage. To support this application, we conducted ...
Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Sung-Eun Noh Seok Jae Lee Chang Sik Cho Dong Hyun Jo Kyu Sang Park Jeong Hun Kim Source Type: research
Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC
Free Radic Biol Med. 2023 Nov 20;209(Pt 2):265-281. doi: 10.1016/j.freeradbiomed.2023.10.409. Epub 2023 Oct 30.ABSTRACTPhenylarsine oxide (PAO), an analog of lewisite, is a highly toxic trivalent arsenical and a potential chemical warfare agent. PAO-induced toxicity has been studied in lung, liver, and skin tissues. Nevertheless, very few studies have been published to comprehend the impact of PAO-induced toxicity on ocular tissues, even though eyes are uniquely vulnerable to injury by vesicants. Notably, arsenical vesicants such as lewisite have been shown to cause edema of eyelids, inflammation, massive corneal necrosis,...
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Kushal Kandhari Rama Kant Neha Mishra Chapla Agarwal Rajesh Agarwal Source Type: research
Live-cell imaging Unveils stimulus-specific dynamics of Nrf2 activation in UV-exposed melanoma cells: Implications for antioxidant compound screening
Free Radic Biol Med. 2023 Dec 11;211:1-11. doi: 10.1016/j.freeradbiomed.2023.12.007. Online ahead of print.ABSTRACTThe transcription factor Nuclear factor e2-related factor 2 (Nrf2) is pivotal in orchestrating cellular antioxidant defense mechanisms, particularly in skin cells exposed to ultraviolet (UV) radiation and electrophilic phytochemicals. To comprehensively investigate Nrf2's role in maintaining cellular redox equilibrium following UV-induced stress, we engineered a novel Nrf2 fusion-based reporter system for real-time, live-cell quantification of Nrf2 activity in human melanoma cells. Utilizing live quantitative ...
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Nilar Win Htut Tasanee Onkoksoong Malinee Saelim Patipark Kueanjinda Somponnat Sampattavanich Uraiwan Panich Source Type: research
Acute and short-term beetroot juice nitrate-rich ingestion enhances cardiovascular responses following aerobic exercise in postmenopausal women with arterial hypertension: A triple-blinded randomized controlled trial
CONCLUSIONS: Acute and short-term BRJ-NO3-rich ingestion may enhance cardiovascular and autonomic behavior in response to aerobic exercise in postmenopausal women diagnosed with SAH.CLINICAL TRIAL REGISTRY NUMBER: https://clinicaltrials.gov/ct2/show/NCT05384340.PMID:38092272 | DOI:10.1016/j.freeradbiomed.2023.11.039 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Cicero Jonas R Benjamim Leonardo Santos L da Silva Yaritza B Alves Sousa Guilherme da Silva Rodrigues Yasmim M de Moraes Pontes Macario Arosti Rebelo Leonardo da Silva Gon çalves Simone Sakagute Tavares Carolina S Guimar ães Andressa C da Silva Sobrinho Source Type: research
Inhibition of ferroptosis underlies EGCG mediated protection against Parkinson's disease in a Drosophila model
In this study, we established a PD model using PINK1 mutant Drosophila. Iron accumulation, lipid peroxidation and decreased activity of GPX, were detected in the brains of PD flies. Additionally, phenotypes of PD, including behavioral defects and dopaminergic neurons loss, were ameliorated by ferroptosis inhibitor ferrostatin-1 (Fer-1). Notably, the increased iron level, lipid peroxidation and decreased GPX activity in the brains of PD flies were relieved by EGCG. We found that EGCG exerted neuroprotection mainly by restoring iron homeostasis in the PD flies. EGCG inhibited iron influx by suppressing Malvolio (Mvl) express...
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Yanzhou Xia Hongyan Wang Zhongwen Xie Zhi-Hua Liu Hui-Li Wang Source Type: research
UCHL3 inhibits ferroptosis by stabilizing β-catenin and maintains stem-like properties of hepatocellular carcinoma cells
In this study, we find that UCHL3 is overexpressed in HCC tissues and correlated with β-catenin protein level. High expression of UCHL3 is associated with poor prognosis. UCHL3 knockdown markedly reduces the protein level of β-catenin in HCC cells. TOP-luciferase activity and β-catenin target genes expression are also decreased upon UCHL3 depletion. We find that the ARM domain of β-catenin is required for the interaction with UCHL3. UCHL3 increases β-catenin protein stability via removing K48-specific poly-ubiquitin chains from β-catenin protein. Furthermore, the depletion of UCHL3 induces ferroptosis and hinders the...
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Guo Long Zheyu Wu Dong Wang Xingyu Mi Kuan Hu Ledu Zhou Jianing Tang Source Type: research
"ATAD3C regulates ATAD3A assembly and function in the mitochondrial membrane"
Free Radic Biol Med. 2023 Dec 11:S0891-5849(23)01151-6. doi: 10.1016/j.freeradbiomed.2023.12.006. Online ahead of print.ABSTRACTMitochondrial ATAD3A is an ATPase Associated with diverse cellular Activities (AAA) domain containing enzyme, involved in the structural organization of the inner mitochondrial membrane and of increasing importance in childhood disease. In humans, two ATAD3A paralogs arose by gene duplication during evolution: ATAD3B and ATAD3C. Here we investigate the cellular activities of the ATAD3C paralog that has been considered a pseudogene. We detected unique ATAD3C peptides in HEK 293T cells, with express...
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Paula Gaud ó Elena de Tom ás-Mateo Nuria Garrido-P érez Alfredo Santana Eduardo Ruiz-Pesini Julio Montoya Pilar Bayona-Bafaluy Source Type: research
Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC
Free Radic Biol Med. 2023 Nov 20;209(Pt 2):265-281. doi: 10.1016/j.freeradbiomed.2023.10.409. Epub 2023 Oct 30.ABSTRACTPhenylarsine oxide (PAO), an analog of lewisite, is a highly toxic trivalent arsenical and a potential chemical warfare agent. PAO-induced toxicity has been studied in lung, liver, and skin tissues. Nevertheless, very few studies have been published to comprehend the impact of PAO-induced toxicity on ocular tissues, even though eyes are uniquely vulnerable to injury by vesicants. Notably, arsenical vesicants such as lewisite have been shown to cause edema of eyelids, inflammation, massive corneal necrosis,...
Source: Free Radical Biology and Medicine - December 13, 2023 Category: Biology Authors: Kushal Kandhari Rama Kant Neha Mishra Chapla Agarwal Rajesh Agarwal Source Type: research
