Tectorigenin inhibits oxidative stress by activating the Keap1/Nrf2/HO-1 signaling pathway in Th2-mediated allergic asthmatic mice
In this study, we created an asthmatic BALB/c mouse model induced by ovalbumin (OVA) and used it to assess the efficacy of tectorigenin as a possible therapy agent. Tectorigenin decreased the serum OVA-specific immunoglobulin (Ig) E and IgG1 secretion levels. The total number of cells and the distribution of inflammatory cells decreased significantly in bronchoalveolar lavage fluid (BALF), with weakened inflammatory reaction in pulmonary tissues. Additionally, tectorigenin regulated the T helper 1(Th1)/Th2 balance by increasing the expression of Th1- related factors (interleukin (IL)-12 and T-bet) and decreasing the expres...
Source: Free Radical Biology and Medicine - December 26, 2023 Category: Biology Authors: Yuna Jiang Thi Van Nguyen Juan Jin Zhen Nan Yu Chang Ho Song Ok Hee Chai Source Type: research
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01176-0. doi: 10.1016/j.freeradbiomed.2023.12.020. Online ahead of print.ABSTRACTSpinal cord injury (SCI) presents profound ramifications for patients, leading to diminished motor and sensory capabilities distal to the lesion site. Once SCI occurs, it not only causes great physical and psychological problems for patients but also imposes a heavy economic burden. Ezrin is involved in various cellular processes, including signal transduction, cell death, inflammation, chemotherapy resistance and the stress response. However, whether Ezrin regulates functional repair after SCI an...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Junsheng Lou Mengran Jin Conghui Zhou Yunpeng Fan Libin Ni Yiting Mao Honghao Shen Jiafeng Li Haojie Zhang Chunyan Fu Xingjia Mao Yingying Chen Jinjie Zhong Kailiang Zhou Linlin Wang Junsong Wu Source Type: research
Glucocorticoids promote steroid-induced osteonecrosis of the femoral head by down-regulating serum alpha-2-macroglobulin to induce oxidative stress and facilitate SIRT2-mediated BMP2 deacetylation
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01182-6. doi: 10.1016/j.freeradbiomed.2023.12.026. Online ahead of print.ABSTRACTOur study investigated the possible molecular mechanism of glucocorticoid in steroid-induced osteonecrosis of the femoral head (SINFH) through regulating serum alpha-2-macroglobulin and SIRT2-mediated BMP2 deacetylation. Essential genes involved in glucocorticoid-induced SINFH were screened by transcriptome sequencing and analyzed by bioinformatics, followed by identifying downstream regulatory targets. Rat bone marrow mesenchymal stem cells were isolated and treated with methylprednisolone (MP) f...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Shanhong Fang Tianmin He Mengqiang You Huixin Zhu Peng Chen Source Type: research
Blocking μ-opioid receptor by naltrexone exaggerates oxidative stress and airway inflammation via the MAPkinase pathway in a murine model of asthma
In conclusion, μOR blocking by naltrexone regulates and implicates inflammation, bronchoconstriction, and lung physiology.PMID:38142953 | DOI:10.1016/j.freeradbiomed.2023.12.023 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Vinita Pandey Vandana Yadav Atul Srivastava Pratikkumar Gaglani Rashmi Singh None Subhashini Source Type: research
Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01183-8. doi: 10.1016/j.freeradbiomed.2023.12.027. Online ahead of print.ABSTRACTEven in the modern era of combination antiretroviral therapy, aberrations in motor control remain a predominant symptom contributing to age-related functional dependencies (e.g., neurocognitive impairment) in people with HIV (PWH). While recent evidence implicates aberrant mitochondrial redox environments in the modulation of neural oscillatory activity serving motor control in PWH, the contribution of important clinical and demographic factors on this bioenergetic-neural-behavioral pathway is unk...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Rachel K Spooner Brittany K Taylor Iman M Ahmad Kelsey Dyball Katy Emanuel Jennifer O'Neill Maureen Kubat Howard S Fox Sara H Bares Kelly L Stauch Matthew C Zimmerman Tony W Wilson Source Type: research
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01176-0. doi: 10.1016/j.freeradbiomed.2023.12.020. Online ahead of print.ABSTRACTSpinal cord injury (SCI) presents profound ramifications for patients, leading to diminished motor and sensory capabilities distal to the lesion site. Once SCI occurs, it not only causes great physical and psychological problems for patients but also imposes a heavy economic burden. Ezrin is involved in various cellular processes, including signal transduction, cell death, inflammation, chemotherapy resistance and the stress response. However, whether Ezrin regulates functional repair after SCI an...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Junsheng Lou Mengran Jin Conghui Zhou Yunpeng Fan Libin Ni Yiting Mao Honghao Shen Jiafeng Li Haojie Zhang Chunyan Fu Xingjia Mao Yingying Chen Jinjie Zhong Kailiang Zhou Linlin Wang Junsong Wu Source Type: research
Glucocorticoids promote steroid-induced osteonecrosis of the femoral head by down-regulating serum alpha-2-macroglobulin to induce oxidative stress and facilitate SIRT2-mediated BMP2 deacetylation
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01182-6. doi: 10.1016/j.freeradbiomed.2023.12.026. Online ahead of print.ABSTRACTOur study investigated the possible molecular mechanism of glucocorticoid in steroid-induced osteonecrosis of the femoral head (SINFH) through regulating serum alpha-2-macroglobulin and SIRT2-mediated BMP2 deacetylation. Essential genes involved in glucocorticoid-induced SINFH were screened by transcriptome sequencing and analyzed by bioinformatics, followed by identifying downstream regulatory targets. Rat bone marrow mesenchymal stem cells were isolated and treated with methylprednisolone (MP) f...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Shanhong Fang Tianmin He Mengqiang You Huixin Zhu Peng Chen Source Type: research
Blocking μ-opioid receptor by naltrexone exaggerates oxidative stress and airway inflammation via the MAPkinase pathway in a murine model of asthma
In conclusion, μOR blocking by naltrexone regulates and implicates inflammation, bronchoconstriction, and lung physiology.PMID:38142953 | DOI:10.1016/j.freeradbiomed.2023.12.023 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Vinita Pandey Vandana Yadav Atul Srivastava Pratikkumar Gaglani Rashmi Singh None Subhashini Source Type: research
Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01183-8. doi: 10.1016/j.freeradbiomed.2023.12.027. Online ahead of print.ABSTRACTEven in the modern era of combination antiretroviral therapy, aberrations in motor control remain a predominant symptom contributing to age-related functional dependencies (e.g., neurocognitive impairment) in people with HIV (PWH). While recent evidence implicates aberrant mitochondrial redox environments in the modulation of neural oscillatory activity serving motor control in PWH, the contribution of important clinical and demographic factors on this bioenergetic-neural-behavioral pathway is unk...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Rachel K Spooner Brittany K Taylor Iman M Ahmad Kelsey Dyball Katy Emanuel Jennifer O'Neill Maureen Kubat Howard S Fox Sara H Bares Kelly L Stauch Matthew C Zimmerman Tony W Wilson Source Type: research
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01176-0. doi: 10.1016/j.freeradbiomed.2023.12.020. Online ahead of print.ABSTRACTSpinal cord injury (SCI) presents profound ramifications for patients, leading to diminished motor and sensory capabilities distal to the lesion site. Once SCI occurs, it not only causes great physical and psychological problems for patients but also imposes a heavy economic burden. Ezrin is involved in various cellular processes, including signal transduction, cell death, inflammation, chemotherapy resistance and the stress response. However, whether Ezrin regulates functional repair after SCI an...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Junsheng Lou Mengran Jin Conghui Zhou Yunpeng Fan Libin Ni Yiting Mao Honghao Shen Jiafeng Li Haojie Zhang Chunyan Fu Xingjia Mao Yingying Chen Jinjie Zhong Kailiang Zhou Linlin Wang Junsong Wu Source Type: research
Glucocorticoids promote steroid-induced osteonecrosis of the femoral head by down-regulating serum alpha-2-macroglobulin to induce oxidative stress and facilitate SIRT2-mediated BMP2 deacetylation
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01182-6. doi: 10.1016/j.freeradbiomed.2023.12.026. Online ahead of print.ABSTRACTOur study investigated the possible molecular mechanism of glucocorticoid in steroid-induced osteonecrosis of the femoral head (SINFH) through regulating serum alpha-2-macroglobulin and SIRT2-mediated BMP2 deacetylation. Essential genes involved in glucocorticoid-induced SINFH were screened by transcriptome sequencing and analyzed by bioinformatics, followed by identifying downstream regulatory targets. Rat bone marrow mesenchymal stem cells were isolated and treated with methylprednisolone (MP) f...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Shanhong Fang Tianmin He Mengqiang You Huixin Zhu Peng Chen Source Type: research
Blocking μ-opioid receptor by naltrexone exaggerates oxidative stress and airway inflammation via the MAPkinase pathway in a murine model of asthma
In conclusion, μOR blocking by naltrexone regulates and implicates inflammation, bronchoconstriction, and lung physiology.PMID:38142953 | DOI:10.1016/j.freeradbiomed.2023.12.023 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Vinita Pandey Vandana Yadav Atul Srivastava Pratikkumar Gaglani Rashmi Singh None Subhashini Source Type: research
Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system
Free Radic Biol Med. 2023 Dec 22:S0891-5849(23)01183-8. doi: 10.1016/j.freeradbiomed.2023.12.027. Online ahead of print.ABSTRACTEven in the modern era of combination antiretroviral therapy, aberrations in motor control remain a predominant symptom contributing to age-related functional dependencies (e.g., neurocognitive impairment) in people with HIV (PWH). While recent evidence implicates aberrant mitochondrial redox environments in the modulation of neural oscillatory activity serving motor control in PWH, the contribution of important clinical and demographic factors on this bioenergetic-neural-behavioral pathway is unk...
Source: Free Radical Biology and Medicine - December 24, 2023 Category: Biology Authors: Rachel K Spooner Brittany K Taylor Iman M Ahmad Kelsey Dyball Katy Emanuel Jennifer O'Neill Maureen Kubat Howard S Fox Sara H Bares Kelly L Stauch Matthew C Zimmerman Tony W Wilson Source Type: research
DNA base oxidation in relation to TNM stages and chemotherapy treatment in colorectal cancer patients 2-9 months post-surgery
In conclusion, DNA base oxidation measured with the enzyme-modified comet assay varies according to tumour and lifestyle related factors in CRC patients treated for non-metastatic disease.PMID:38141887 | DOI:10.1016/j.freeradbiomed.2023.12.016 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - December 23, 2023 Category: Biology Authors: Anne Lene Nordengen Ane S Kv ærner Annika Krutto Dena T Alavi Hege B Henriksen Christine Henriksen Truls Raastad Sigbj ørn Smeland Siv K B øhn Sergey Shaposhnikov Andrew R Collins Rune Blomhoff Source Type: research
Superoxide, nitric oxide and peroxynitrite production by macrophages under different physiological oxygen tensions
Free Radic Biol Med. 2023 Dec 21:S0891-5849(23)01180-2. doi: 10.1016/j.freeradbiomed.2023.12.024. Online ahead of print.ABSTRACTMacrophages count on two O2-consuming enzymes to form reactive radical species: NAPDH oxidase 2 (Nox2) and nitric oxide synthase 2 (inducible isoform, iNOS) that produce superoxide radical (O2•-) and nitric oxide (•NO), respectively. If formed simultaneously, the diffusion-controlled reaction of O2•- and •NO yields peroxynitrite, a potent cytotoxic oxidant. In human tissues and cells, the oxygen partial pressure (pO2) normally ranges within 2-14 %, with a typical average pO2 value for most...
Source: Free Radical Biology and Medicine - December 23, 2023 Category: Biology Authors: Ana Clara Casella Carolina Prolo Josefina Pereyra Natalia R íos Luc ía Piacenza Rafael Radi Mar ía Noel Álvarez Source Type: research
