Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma

In conclusion, our study uncovers the anticancer mechanism of agrimol B in HCC involving the regulation of oxidative stress and autophagy, and suggests agrimol B as a potential therapeutic drug for HCC treatment.PMID:38697493 | DOI:10.1016/j.freeradbiomed.2024.04.242

Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Lixia Dong Li Luo Zihao Wang Shan Lian Mao Wang Xingyun Wu Jiawu Fan Yan Zeng Sijia Li Sinan Lv Yurong Yang Rong Chen Enhao Shen Wenyong Yang Changlong Li Kui Wang Source Type: research