Fertility and infertility implications in rheumatoid arthritis; state of the art
ConclusionsA complex interaction between RA disease and fertility related issues is present. Despite an increase rate of infertility in RA females or males, the mechanisms involved in this outcome is still unknown. Plausible causes of the decreased fertility rate in RA patients might be due to inflammatory cytokines, suppressed sexual activity, drug treatments, mother age, personal choice, or a combination of these elements. (Source: Inflammation Research)
Source: Inflammation Research - May 26, 2020 Category: Research Source Type: research

TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease
ConclusionsAll in all, these experimental outcomes indicated that TMEM88 had an indispensable impact on EtOH-induced secretion of inflammatory cytokines (IL-6 and IL-1 β) in RAW264.7 cells through YAP signaling pathway. (Source: Inflammation Research)
Source: Inflammation Research - May 25, 2020 Category: Research Source Type: research

Inflammasome activation in podocytes: a new mechanism of glomerular diseases
AbstractIntroductionInflammasome is a multi-protein complex which is an important constituent of innate immunity. It mainly consists of three parts, apoptosis-associated speck-like protein containing caspase recruitment domain (ASC), caspase protease, and a NOD-like receptor (NLR) family protein (such as NLRP1) or an HIN200 family protein (such as AIM2). Inflammasome is widely studied in many autoimmune diseases and chronic inflammatory reactions, such as familial periodic autoinflammatory response, type 2 diabetes, Alzheimer's disease, and atherosclerosis. Activation of inflammasome in the kidney has been widely reported ...
Source: Inflammation Research - May 24, 2020 Category: Research Source Type: research

LPS-induced inflammation disorders bone modeling and remodeling by inhibiting angiogenesis and disordering osteogenesis in chickens
In this study, we explored the influence of inflammation on bone formation in broilers for the first time by using lipopolysaccharide (LPS) to establish systemic inflammatory models in chickens with tibia as the research object. The measurements of production and tibial parameters showed an inefficient production performance and lower growth rate in LPS group. We also found a large amount of platelets, inflammatory cells in chickens ’ blood and higher levels of inflammatory factors in serum after LPS injection, meanwhile, increase in thrombus, chondrocyte nucleolysis, and osteoclasts and a reduction in blood vessels ...
Source: Inflammation Research - May 22, 2020 Category: Research Source Type: research

The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes
ConclusionThese findings suggest that PNX-14 may have potential in the treatment of neuroinflammation. (Source: Inflammation Research)
Source: Inflammation Research - May 20, 2020 Category: Research Source Type: research

Immunoglobulin free light chains: an inflammatory biomarker of diabetes
ConclusionsThese results suggest that FLC kappa/lambda may be more specific and sensitive for the diagnosis of T2D than HbA1c, and thus represents a potentially promising biomarker of inflammation. (Source: Inflammation Research)
Source: Inflammation Research - May 18, 2020 Category: Research Source Type: research

Jumonji domain containing-3 (JMJD3)  inhibition attenuates IL-1β-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo
ConclusionsThis study elucidates the important role of JMJD3 in cartilage degeneration in OA, and our results indicate that JDJM3 may become a novel therapeutic target in OA therapy. (Source: Inflammation Research)
Source: Inflammation Research - May 11, 2020 Category: Research Source Type: research

SARS-CoV-2-mediated inflammatory response in lungs: should we look at RAGE?
AbstractThe novel coronavirus disease (COVID-19) pandemic is placing significant strains on health systems, scientific communities, essential public services, and economies all over the world. In this context, the world ´s scientific biomedical establishment is unleashing an unprecedented response to the COVID-19 pandemic. This is a battle against time, considering the thousands of human lives are lost every day. In this commentary, based on a very recent research report, we intend to highlight how a new mechanism describing the RAGE transactivation produced by Ang II-mediated ATR1 activation can run continuously and...
Source: Inflammation Research - May 5, 2020 Category: Research Source Type: research

SARS-CoV-2 will continue to circulate in the human population: an opinion from the point of view of the virus-host relationship
AbstractAt the population level, the virus-host relationship is not set up to end with the complete elimination of either or both. Pathogen-resistant individuals will always remain in the host population. In turn, the virus can never completely eliminate the host population, because evolutionarily such an event is a dead end for the virus as an obligate intracellular parasite. A certain existential balance exists in the virus-host relationship. Against this backdrop, viral epidemics and pandemics only become manifest and egregious to human beings when tens and hundreds of thousands of people die and the question emerges wh...
Source: Inflammation Research - April 30, 2020 Category: Research Source Type: research

Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation
ConclusionSAE increased NLRP3 and Nrf2 expression in microglia. Hydrogen alleviated inflammation, neuronal apoptosis and mitochondrial dysfunction via inhibiting Nrf2-mediated NLRP3 pathway. (Source: Inflammation Research)
Source: Inflammation Research - April 30, 2020 Category: Research Source Type: research

LncRNA promoted inflammatory response in ischemic heart failure through regulation of miR-455-3p/TRAF6 axis
ConclusionsOur results reveal that SOX2-OT may be a driver of IHF through repression of miR-455-3p, and miR-455-3p alleviates IHF by targeting TRAF6. Therefore, SOX2-OT/miR-455-3p/TRAF6 may be a potential target for advanced therapeutic strategy for IHF. (Source: Inflammation Research)
Source: Inflammation Research - April 29, 2020 Category: Research Source Type: research

Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation
ConclusionsThe NLRP3 inflammasome was activated by elevated mitoROS levels and mediated HBx-induced liver inflammation and hepatocellular pyroptosis under H2O2-stress conditions. (Source: Inflammation Research)
Source: Inflammation Research - April 28, 2020 Category: Research Source Type: research

SIKIAT1/miR-96/FOXA1 axis regulates sepsis-induced kidney injury through induction of apoptosis
ConclusionTherefore, it could be a potential biomarker and therapeutic target for sepsis-induced AKI in the development of disease. (Source: Inflammation Research)
Source: Inflammation Research - April 27, 2020 Category: Research Source Type: research

MiR-146a-5p promotes IL-1 β-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway
ConclusionsThis work showed that miR-146 induces chondrocyte apoptosis by targeting the TRAF6-mediated NF-KB signaling pathway, and miR-146 may be a potential target for OA treatment. (Source: Inflammation Research)
Source: Inflammation Research - April 23, 2020 Category: Research Source Type: research

Combination of saikosaponin c and telbivudine synergistically enhances the anti-HBV activity
ConclusionThese in vitro results indicated that SSc acted as a promising nucleoside analogue adjuvant, especially for telbivudine in the therapeutic strategies against HBV infection. (Source: Inflammation Research)
Source: Inflammation Research - April 20, 2020 Category: Research Source Type: research

Characteristics of voltage-gated potassium currents in monosodium urate induced gouty arthritis in mice
ConclusionsMSU-induced gout pain may be related to the hyperexcitability of DRG neurons elicited by decreasing K+ currents. (Source: Inflammation Research)
Source: Inflammation Research - April 18, 2020 Category: Research Source Type: research

Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF- кB pathway
ConclusionThis study suggests the involvement of energy metabolism in the pathological inflammation process in RA joints. Glycolysis inhibitors might, therefore, provide an opportunity for therapeutic intervention. (Source: Inflammation Research)
Source: Inflammation Research - April 18, 2020 Category: Research Source Type: research

CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro
ConclusionTaken together, the findings demonstrate that CHRFAM7A regulates the biological activity of monocytes/macrophages to migrate and undergo anchorage-independent growth in vitro. (Source: Inflammation Research)
Source: Inflammation Research - April 17, 2020 Category: Research Source Type: research

LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia
ConclusionsOur results demonstrated that SNHG5 affected the expression of SOX4 through binding miR-489-3p to regulate proliferation and apoptosis of AML, which might act as a prospective prognostic biological marker and a promising therapeutic target for AML. (Source: Inflammation Research)
Source: Inflammation Research - April 7, 2020 Category: Research Source Type: research

Correction to: Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1 α/VEGF signaling pathway
In the original publication of the article (Source: Inflammation Research)
Source: Inflammation Research - April 3, 2020 Category: Research Source Type: research

The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis
AbstractPurposeCannabis has been used for thousands of years in many cultures for the treatment of several ailments including pain. The benefits of cannabis are mediated largely by cannabinoids, the most prominent of which are tetrahydrocannabinol (THC) and cannabidiol (CBD). As such, THC and/or CBD have been investigated in clinical studies for the treatment of many conditions including neuropathic pain and acute or chronic inflammation. While a plethora of studies have examined the biochemical effects of purified THC and/or CBD, only a few have focused on the effects of full-spectrum cannabis plant extract. Accordingly, ...
Source: Inflammation Research - April 1, 2020 Category: Research Source Type: research

The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients
ConclusionsTherapeutic regimens of IFN- α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. (Source: Inflammation Research)
Source: Inflammation Research - March 29, 2020 Category: Research Source Type: research

Down-regulation of lncRNA CASC9 aggravates sepsis-induced acute lung injury by regulating miR-195-5p/PDK4 axis
ConclusionCASC9 protects lung epithelial cells from sepsis-induced injury via regulating miR-195-5p/PDK4 axis. (Source: Inflammation Research)
Source: Inflammation Research - March 27, 2020 Category: Research Source Type: research

Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells
ConclusionsLL-37 potentiates dsRNA-induced cytokine production through up-regulation of TLR3 expression representing a novel pro-inflammatory mechanism. (Source: Inflammation Research)
Source: Inflammation Research - March 27, 2020 Category: Research Source Type: research

Interleukin 23 and autoimmune diseases: current and possible future therapies
AbstractPurposeIL-23 is a central proinflammatory cytokine with a wide range of influence over immune response. It is implicated in several autoimmune diseases due to the infinite inflammatory loops it can create through the positive feedbacks of both IL-17 and IL-22 arms. This made IL-23 a key target of autoimmune disorders therapy, which indeed was proven to inhibit inflammation and ameliorate diseases. Current autoimmune treatments targeting IL-23 are either by preventing IL-23 ligation to its receptor (IL-23R) via antibodies or inhibiting IL-23 signaling by signaling downstream mediators ’ inhibitors, with each a...
Source: Inflammation Research - March 25, 2020 Category: Research Source Type: research

Influence of estradiol treatment on bone marrow cell differentiation in collagenase-induced arthritis
ConclusionResults indicate a potential protective role for estrogen against the development of OA. (Source: Inflammation Research)
Source: Inflammation Research - March 21, 2020 Category: Research Source Type: research

IL-18/IL-18R1 promotes circulating fibrocyte differentiation in the aging population
ConclusionCirculating fibrocytes from elders had an enhanced capacity to differentiate into myofibroblasts, and might contribute to age-dependent fibrosis. Age-dependent increment of differentiation at least in part arose from their enhanced expression of IL-18R1. Inhibiting fibrocyte differentiation might be useful as an adjuvant treatment to delay the fibrosis process in aging population. (Source: Inflammation Research)
Source: Inflammation Research - March 19, 2020 Category: Research Source Type: research

Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization
ConclusionsMacrophage M2 polarization is likely the cellular mechanism underlying the anti-AKI property of AQP1, and PI3K activation is involved in the AQP1-induced M2 phenotype switch. (Source: Inflammation Research)
Source: Inflammation Research - March 16, 2020 Category: Research Source Type: research

Vitamin D and connective tissue diseases
ConclusionsThe limitations of the study, such as the heterogeneity of patients, methods used to measure vitamin D serum concentration and other biases, do not lead to unequivocal results to demonstrate a direct link between low vitamin D serum levels and autoimmune diseases. Further studies are needed to resolve conflicting results. (Source: Inflammation Research)
Source: Inflammation Research - March 14, 2020 Category: Research Source Type: research

CXCR7 suppression modulates macrophage phenotype and function to ameliorate post-myocardial infarction injury
ConclusionsOur data demonstrate that CXCR7 suppression inhibits macrophages M1 polarization, chemotaxis and inflammation to ameliorate post-MI injury, providing novel insights and promising therapy approaches in post-MI treatment. (Source: Inflammation Research)
Source: Inflammation Research - March 13, 2020 Category: Research Source Type: research

Tumor-derived exosomes in the regulation of macrophage polarization
ConclusionBased on the vesicular cargo, the molecular constituents, the exosomes have the potential to change the fate of macrophage phenotypes, either M1, classically activated macrophages, or M2, alternatively activated macrophages. In this review, we discuss and describe the ability of tumor-derived exosomes in the mechanism of macrophage activation and polarization. (Source: Inflammation Research)
Source: Inflammation Research - March 11, 2020 Category: Research Source Type: research

H 2 S counteracts proinflammatory effects of LPS through modulation of multiple pathways in human cells
ConclusionBased on the obtained results we believe that our transcriptomic analysis significantly contributes to the understanding of the molecular mechanisms of anti-inflammatory and cytoprotective activity of hydrogen sulfide donors, and highlights their potential against LPS challenges and other forms of inflammation. (Source: Inflammation Research)
Source: Inflammation Research - March 11, 2020 Category: Research Source Type: research

Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF- κB pathway
ConclusionTaken together, our findings show that Aloperine could suppress LPS-induced macrophage activation by inhibiting the TLR4/Myd-88/NF- κB pathway. (Source: Inflammation Research)
Source: Inflammation Research - March 7, 2020 Category: Research Source Type: research

Macrophage mediation in normal and diabetic wound healing responses
ConclusionThe development of targeted therapies and also developing a reliable means to monitor assisted healing of chronic wounds are two major goals to be pursued. In addition, identifying molecular targets that can regulate macrophages to aid tissue restoration in chronic wounds would serve the crucial step in realizing both aforementioned goals. (Source: Inflammation Research)
Source: Inflammation Research - March 7, 2020 Category: Research Source Type: research

Gallic acid protects against the COPD-linked lung inflammation and emphysema in mice
ConclusionOverall, our data show that GA effectively modulates pulmonary inflammation and emphysema associated with COPD pathogenesis in mice. (Source: Inflammation Research)
Source: Inflammation Research - March 6, 2020 Category: Research Source Type: research

Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1 α/VEGF signaling pathway
ConclusionEmodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1 α/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI. (Source: Inflammation Research)
Source: Inflammation Research - March 4, 2020 Category: Research Source Type: research

Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF- κB signaling pathway inhibition
ConclusionsIn summary, celastrol protected against chondrocyte apoptosis by promoting autophagy and inhibiting NF- κB signaling pathway in vitro and in vivo. (Source: Inflammation Research)
Source: Inflammation Research - February 28, 2020 Category: Research Source Type: research

Novel adipokine associated with OA: retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients
ConclusionsWe show here, for the first time, that RBP4 is produced within OA joints and that it is associated with increased levels of adipokines and MMPs. The results suggest a role for RBP4 in the pathogenesis of OA and as a possible target for the disease-modifying drugs for the treatment of OA. (Source: Inflammation Research)
Source: Inflammation Research - February 24, 2020 Category: Research Source Type: research

Association between serum amyloid A levels and coronary heart disease: a systematic review and meta-analysis of 26 studies
ConclusionHigh levels of SAA are significantly associated with increased risk of CHD, especially for participants aged more than 55  years, subjects from Europe and Asia, or case–control study. Furthermore, we find that SAA concentrations increased with the severity of CHD. Importantly, our study suggests that high levels of SAA might play a role in CHD by increasing CRP, fibrinogen, IL-6 levels, or attenuating HDL-C levels. (Source: Inflammation Research)
Source: Inflammation Research - February 22, 2020 Category: Research Source Type: research

NKp46+ lamina propria natural killer cells undergo metabolic reprogramming in a mouse experimental colitis model
ConclusionsLPNK cells undergo metabolic reprogramming which might be a response to upcoming microbial infection in acute colitis. (Source: Inflammation Research)
Source: Inflammation Research - February 10, 2020 Category: Research Source Type: research

Identification and evaluation of hub mRNAs and long non-coding RNAs in neutrophils during sepsis
ConclusionsBased on a new biological approach, our research results revealed the systemic-level response of neutrophils to sepsis and identified several hub lncRNAs with potential regulatory effects on this condition. (Source: Inflammation Research)
Source: Inflammation Research - February 5, 2020 Category: Research Source Type: research

Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation
ConclusionOur data showed that 30  days after ACLT is sufficient to induce signs of KOA in rats, such as pain, functional impairment, and synovial inflammation, suggesting that a shorter time period can be used as an experimental model. (Source: Inflammation Research)
Source: Inflammation Research - January 31, 2020 Category: Research Source Type: research

miR-425-5p improves inflammation and septic liver damage through negatively regulating the RIP1-mediated necroptosis
ConclusionsThe data suggest miR-425-5p negatively controls the RIP1-mediated necroptotic signaling cascades and inflammation, and sepsis-related liver damage. miR-425-5p/RIP1 axis is a potential therapeutic strategy for sepsis-related liver damage through necroptosis and inflammation. (Source: Inflammation Research)
Source: Inflammation Research - January 30, 2020 Category: Research Source Type: research

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling
ConclusionThese findings indicate that igalan, via suppressing JAK/STAT3 signaling, could impair the production of pro-inflammatory chemokines and enhance expression levels of several genes involved in keratinocyte differentiation in AD-like stimulated keratinocytes. (Source: Inflammation Research)
Source: Inflammation Research - January 30, 2020 Category: Research Source Type: research

Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B3
ConclusionsRPMCs expressing functional MRGPRB3 response upon MRGPRX2 ligands to regulated MC-mediated activities. It`s provide novel insights for future pseudo-allergic studies in rodents. (Source: Inflammation Research)
Source: Inflammation Research - January 28, 2020 Category: Research Source Type: research

Tissue-resident memory T cells in the skin
AbstractPurposeTissue-resident memory T (TRM) cells are a newly described subset of memory T cells. The best characterized TRM cells are CD8+ and express CD103 and CD69. These cells are non-recirculating and persist long term in tissues, providing immediate protection against invading pathogens. However, their inappropriate activation might contribute to the pathogenesis of autoimmune and inflammatory disorders. In the skin, these cells have been described in psoriasis, vitiligo, and melanoma among other diseases.MethodsLiterature review was done to highlight what is currently known on the phenotype and function of TRM cel...
Source: Inflammation Research - January 27, 2020 Category: Research Source Type: research

lncRNA H19 sponging miR-93 to regulate inflammation in retinal epithelial cells under hyperglycemia via XBP1s
ConclusionsH19 played an important role in regulating inflammatory processes in retinal endothelial cells under high-glucose condition through modulating miR-93/XBP1s axis. (Source: Inflammation Research)
Source: Inflammation Research - January 17, 2020 Category: Research Source Type: research

The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases
This article reviews the advances research of pyroptosis initiated by i nflammasome in inflammatory and immune diseases. (Source: Inflammation Research)
Source: Inflammation Research - January 13, 2020 Category: Research Source Type: research

Letter to the editor regarding Gholamzad et al., “A comprehensive review on the treatment approaches of multiple sclerosis: currently and in the future”
(Source: Inflammation Research)
Source: Inflammation Research - January 11, 2020 Category: Research Source Type: research

Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome by protecting against glycocalyx damage and suppressing inflammatory signaling pathways
ConclusionCrocin alleviated LPS-induced ARDS by protecting against glycocalyx damage and suppressing inflammatory signaling pathways. (Source: Inflammation Research)
Source: Inflammation Research - January 10, 2020 Category: Research Source Type: research