Emerging perspectives on mitochondrial dysfunctioning and inflammation in epileptogenesis
ConclusionThe current review highlights the further opportunity for establishing therapeutic interventions underlying the apparent correlation of neuroinflammation mediated mitochondrial oxidative stress might contribute to common intracellular mechanisms underlying a future prospective of drug treatment targeting mitochondrial dysfunction linked to the neuroinflammation in epilepsy. (Source: Inflammation Research)
Source: Inflammation Research - October 15, 2021 Category: Research Source Type: research

miR-451-3p alleviates myocardial ischemia/reperfusion injury by inhibiting MAP1LC3B-mediated autophagy
ConclusionsmiR-451-3p played a protective role in MIRI via inhibiting MAP1LC3B-mediated autophagy, which may provide new molecular targets for the treatment of MIRI and further improves the clinical outcomes of heart diseases. (Source: Inflammation Research)
Source: Inflammation Research - October 11, 2021 Category: Research Source Type: research

C/EBP β is a key transcription factor of ox-LDL inducing THP-1 cells to release multiple pro-inflammatory cytokines
ConclusionOur results suggest that ox-LDL stimulation enhances C/EBP β-regulated transcription in THP-1 and C/EBPβ upregulate the release of multiple pro-inflammatory cytokines including IL-18, IL-1β, and IL-6 through direct binding to genes. (Source: Inflammation Research)
Source: Inflammation Research - October 4, 2021 Category: Research Source Type: research

Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis
ConclusionsThe present systematic review and meta-analysis demonstrate an overall association betweenIL6 -174 G/C polymorphism and CAD, which seems to be mainly driven by Asian and Asian Indian ancestral subgroups. Upregulation of plasma IL-6 levels in the ‘C’ allele carriers seems to be at least partly responsible for this observed association. This warrants further investigations with large, structured case–control studies especially amongst Asian and Asian Indian ancestral groups. (Source: Inflammation Research)
Source: Inflammation Research - September 30, 2021 Category: Research Source Type: research

NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn
ConclusionNORAD lentivirus shRNA improved cardiac function and fibrosis and reduced inflammatory responses in DCM mice via the ceRNA network of NORAD/miR-125a-3p/Fyn. These findings provide a valuable and promising therapeutic target for the treatment of DCM. (Source: Inflammation Research)
Source: Inflammation Research - September 30, 2021 Category: Research Source Type: research

The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind placebo-controlled phase III CORONA clinical study
ConclusionIn patients with radiologically confirmed SARS-CoV-2 pneumonia, requiring or not oxygen therapy (but not ventilation) with no signs of other active infection administration of LVL  + SOC results in an increase of sustained clinical improvement rate.Trail registrationThe trial is registered at the US National Institutes of Health (ClinicalTrials.gov; NCT04397562). (Source: Inflammation Research)
Source: Inflammation Research - September 29, 2021 Category: Research Source Type: research

The role of NK cells in rheumatoid arthritis
ConclusionCollectively, the evidence collected in the current review emphasizes the possible protective role of CD56dim NK cells in the pathogenesis of RA. (Source: Inflammation Research)
Source: Inflammation Research - September 27, 2021 Category: Research Source Type: research

Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways
ConclusionOsteoarthritic IPFP induces the degradation and inflammation of cartilage via activation of p38MAPK and ERK1/2 pathways, in which IL-1 β and TNF-α act as the key factors. Our study suggests that modulating the effects of IPFP on cartilage may be a promising strategy for knee OA intervention. (Source: Inflammation Research)
Source: Inflammation Research - September 25, 2021 Category: Research Source Type: research

Adverse Ocular Events following COVID-19 Vaccination
(Source: Inflammation Research)
Source: Inflammation Research - September 24, 2021 Category: Research Source Type: research

Analysis of five cases of monogenic lupus related to primary immunodeficiency diseases
ConclusionsMultiple PIDs can lead to monogenic lupus. Different PID-related monogenic lupus has different suitable targeted drugs. (Source: Inflammation Research)
Source: Inflammation Research - September 24, 2021 Category: Research Source Type: research

gga-miR-142-3p negatively regulates Mycoplasma gallisepticum (HS strain)-induced inflammatory cytokine production via the NF- κB and MAPK signaling by targeting TAB2
ConclusionUpon MG infection, upregulation of gga-miR-142-3p alleviates inflammation by negatively regulating the signaling pathways of NF- κB and MAPKs by targeting TAB2 and facilitates cell proliferation by inhibiting cell apoptosis and promoting cell cycle progression to defend against MG infection. (Source: Inflammation Research)
Source: Inflammation Research - September 23, 2021 Category: Research Source Type: research

Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer
ConclusionThe present review article aimed to discuss these potential long-lasting changes induced byH. pylori infection that may follow the eradication ofH. pylori and contribute to the development of GC. (Source: Inflammation Research)
Source: Inflammation Research - September 21, 2021 Category: Research Source Type: research

Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells —“utilization” of ferroptosis mechanism
ConclusionWe demonstrate the significance of GPX4 and intracellular iron level in ovarian cancer cells. Importantly, inhibition of GPX4 interferes with both intracellular iron homeostasis and lipid peroxide reducibility, inducing ferroptosis and exerting anti-cancer effect, which can be a potential effective strategy for ovarian cancer therapy. (Source: Inflammation Research)
Source: Inflammation Research - September 19, 2021 Category: Research Source Type: research

The impact of CD4+CD28null T lymphocytes on atrial fibrillation: a potential pathophysiological pathway
ConclusionConsidering the available data in the literature, it needs to be assumed that CD4+CD28null T lymphocytes are mainly involved in the development of AF and disease progression. Of utmost importance, it can be considered as the result of a T-cell-mediated auto-immune reaction among myocardial tissue. However, mechanisms which recruit CD4+CD28null cells in cardiac tissue remain unclear and need further investigation. (Source: Inflammation Research)
Source: Inflammation Research - September 18, 2021 Category: Research Source Type: research

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
ConclusionsGiven that cellular senescence, inflammaging, and counteracting immune suppression increase with aging, this might explain why excessive insulin/IGF-1 signaling promotes the aging process. (Source: Inflammation Research)
Source: Inflammation Research - September 2, 2021 Category: Research Source Type: research

S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1
AbstractUV-B stimulation can induce retinopathy, whose pathogenesis is currently unclear. UV-B mediated inflammation in retinal endothelial cells is reported to be involved in the pathogenesis of retinopathy. S14G-humanin (HNG) is a neuroprotective peptide that has recently been reported to exert significant anti-inflammatory effects and protective properties against cell death. The present study aims to investigate the protective effects of HNG against UV-B-challenged retinal endothelial cells and explore the underlying mechanism. UV-B radiation was used to induce an injury model in human retinal endothelial cells (HRECs)...
Source: Inflammation Research - August 30, 2021 Category: Research Source Type: research

Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus
ConclusionAnti-HMGB1 mAb might be an effective therapy for severe influenza ARDS. (Source: Inflammation Research)
Source: Inflammation Research - August 29, 2021 Category: Research Source Type: research

COVID-19 disrupts the blood –testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins
ConclusionsOverall, the present study demonstrated that SARS-CoV-2 could induce the up-regulation of the pro-inflammatory cytokine and down-regulation of junctional proteins of the BTB, which can disrupt BTB and ultimately impair spermatogenesis. (Source: Inflammation Research)
Source: Inflammation Research - August 26, 2021 Category: Research Source Type: research

Bladder mesenchymal stromal cell-derived exosomal miRNA-217 modulates bladder cancer cell survival through Hippo-YAP pathway
AbstractBackgroundDonor cell-derived exosomes regulate recipient cell functions. The aim of this study was to investigate the effect of human normal bladder stromal cell (hBSC) derived exosomal miR-217 on bladder cell cancer proliferation and migration.MethodsHuman BSCs were transfected with miR-217 mimic or inhibitor and hBSC-derived exosomes were isolated. Human bladder cancer cell lines (T24 and 5367) were co-cultured with hBSC-derived exosomal miR-217 mimic or inhibitor. Proliferation, migration, and apoptosis of the bladder cancer cells were assessed by Edu assay, Transwell migration assay, and Annexin V assay.Results...
Source: Inflammation Research - August 14, 2021 Category: Research Source Type: research

A case of reactivation of varicella –zoster virus after BNT162b2 vaccine second dose?
We report a case of itchy papulovesicular rash consistent with varicella –zoster virus reactivation after Pfizer-BioNTech vaccine second dose administration. While there have been cases of varicella–zoster virus reactivation due to COVID-19 or COVID-19 vaccine inoculation in older individuals with pre-existing conditions, this case report describes the first case of varicella–zoster virus reactivation on a healthy, young male in the absence of pre-existing conditions. The mechanisms underlying varicella-zoster virus reactivation in patients with COVID-19 are unknown and should be further characterize...
Source: Inflammation Research - August 14, 2021 Category: Research Source Type: research

Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis
ConclusionOur results suggested that intermediate monocytes with high expression of PD-1 may be involved in the progression of sepsis. PD-1 might play a critical role in regulating the pyroptosis signalling pathway in sepsis. (Source: Inflammation Research)
Source: Inflammation Research - August 11, 2021 Category: Research Source Type: research

Montelukast potentiates the antiinflammatory effect of NSAIDs in the rat paw formalin model and simultaneously minimizes the risk of gastric damage
ConclusionsWhile montelukast equally enhances antiinflammatory action of diclofenac or celecoxib via downregulating iNOS/COX2/LTs/IL-6 signaling, its gastroprotective action is preferentially potentiated by celecoxib. (Source: Inflammation Research)
Source: Inflammation Research - August 11, 2021 Category: Research Source Type: research

TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis
ConclusionOverall, our results proved that TREM-1 promoted the lung injury and inflammation in COPD mouse through activation of NLRP3 inflammasome-mediated pyroptosis. Our data indicated a novel mechanism of TREM-1 in COPD development, and maybe provide a novel therapeutic target for COPD treatment. (Source: Inflammation Research)
Source: Inflammation Research - August 10, 2021 Category: Research Source Type: research

A spotlight on underlying the mechanism of AMPK in diabetes complications
ConclusionFrom the available information, it may be concluded that various indirect/direct activators show tremendous potential in maintaining the homeostasis of glucose and lipid metabolism, without resulting in insulin resistance, and may improve insulin sensitivity, as well. Therefore, in a nut shell, it may be concluded that the regulation of APMK functions by various direct/indirect activators may bring promising results. These activators may emerge as a novel therapy in diabetes and its associated complications. (Source: Inflammation Research)
Source: Inflammation Research - July 28, 2021 Category: Research Source Type: research

SARS-CoV-2 and pathological matrix remodeling mediators
ConclusionTargeting MMPs and their inhibitors could be a probable solution for occurred events since there are many cured patients that remain with severe sequels even after the end of infection. (Source: Inflammation Research)
Source: Inflammation Research - July 20, 2021 Category: Research Source Type: research

MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer
ConclusionOur results suggest thatMIR452 regulates STAT3 through the IL20RA-mediated JAK1 pathway, but not STAT1. Overall,MIR452 acts as tumor suppressor in human CRC and in a mouse colitis model. These findings suggest thatMIR452 is a promising therapeutic target in the treatment of cancer and colitis. (Source: Inflammation Research)
Source: Inflammation Research - July 20, 2021 Category: Research Source Type: research

The pathophysiology of immunoporosis: innovative therapeutic targets
ConclusionThis review presents alternative pathways in the pathophysiology of osteoporosis, along with some recent therapeutic breakthroughs to restore bone homeostasis. (Source: Inflammation Research)
Source: Inflammation Research - July 16, 2021 Category: Research Source Type: research

Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy
ConclusionThese results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury. (Source: Inflammation Research)
Source: Inflammation Research - July 10, 2021 Category: Research Source Type: research

Pseudomonas aeruginosa outer membrane vesicles ameliorates lung ischemia –reperfusion injury by regulating the balance of regulatory T cells and Th17 cells through Tim-3 and TLR4/NF-κB pathway
ConclusionsThese results suggest that OMVs preconditioning may ameliorate lung I/R injury by regulating the balance of Tregs and Th17 cells through Tim-3 and TLR4/NF- κB pathway. (Source: Inflammation Research)
Source: Inflammation Research - July 5, 2021 Category: Research Source Type: research

CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis
In conclusion, circ-ITCH alleviated renal inflammation and fibrosis in STZ-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis.Author names: Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 1 Given name: [ChunYang] Last name [Xu]. Author 2 Given name: [DingBo] Last name [Xu]. Author 3 Given name: [YongHua] Last name [Liu]. Author 4 Given name: [Juanjuan] Last name [Jiang]. Also, kindly confirm the details in the metadata are correct.ok (Source: Inflammation Research)
Source: Inflammation Research - July 3, 2021 Category: Research Source Type: research

Mechanistic and physiological approaches of fecal microbiota transplantation in the management of NAFLD
AbstractNon-alcoholic fatty liver disease (NAFLD) is a multifaceted disease allied with various metabolic disorders, obesity and dysbiosis. Gut microbiota plays an influential role in the pathogenesis of NAFLD and other metabolic disorders. However, recent scientific upsurge emphasizes on the utility of beneficial gut microbiota and bacteriotherapy in the management of NAFLD. Fecal microbiota transplantation (FMT) is the contemporary therapeutic approach with state-of-the-art methods for the treatment of NAFLD. Other potential therapies include probiotics and prebiotics supplements which are based on alteration of gut micr...
Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research

Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells
ConclusionsThus, our data suggest that caspase-1, IL-1 β and IL-18 may contribute to the inflammatory status observed in SCA and that HU treatment may not interfere in this inflammatory pathway. (Source: Inflammation Research)
Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research

Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease
AbstractJanus kinase/signal transduction and transcriptional activator (JAK/STAT) signaling pathway is a transport hub for cytokine secretion and exerts its effects. The activation of JAK/STAT signaling pathway is essential for the regulation of inflammatory responses. Inappropriate activation or deletion of JAK/STAT signaling pathway is the initiator of the inflammatory response. JAK/STAT signaling pathway has been demonstrated to be involved in the process of innate and adaptive immune response to inflammatory bowel disease (IBD). In this review, we discuss the role of the JAK/STAT signaling pathway in the regulation of ...
Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research

Mechanism of bone marrow mesenchymal stem cells secreting miR-26a exosomes affecting high glucose-induced skin fibroblasts function by regulating TLR4/NF- κB signaling
ConclusionThese results suggest that hMSCs cells secreting miR-26a exosomes inhibited the proliferation, migration, and transdifferentiation of high glucose-induced BJ cells, and promoted cell apoptosis, which may be related to the TLR4/NF- κB signaling pathway. (Source: Inflammation Research)
Source: Inflammation Research - June 29, 2021 Category: Research Source Type: research

Evolution of β-catenin-independent Wnt–GSK3–mTOR signalling in regulation of energy metabolism in isoproterenol-induced cardiotoxicity model
ConclusionWe hereby discuss a novel therapeutic role of the β-catenin independent, Wnt–GSK3–mTOR axis in attenuation of Iso-induced cardiotoxicity in rodents. (Source: Inflammation Research)
Source: Inflammation Research - June 29, 2021 Category: Research Source Type: research

How could perfluorocarbon affect cytokine storm and angiogenesis in coronavirus disease 2019 (COVID-19): role of hypoxia-inducible factor 1 α
AbstractCoronavirus disease 2019 (COVID-19) pandemic is still a world-class challenge. Inflammation, especially its severe form with excess release of pro-inflammatory cytokines (cytokine storm) which is a life-threatening condition, is among the most important suspects involved in COVID-19 pathogenesis. It has been shown that cytokine storm could cause notable morbidities such as acute respiratory distress syndrome (ARDS) which leads to hypoxia which is significantly associated with mortality of patients with COVID-19. Hypoxia-inducible factor 1 α (HIF-1α) which activates following ARDS-induced hypoxia plays a...
Source: Inflammation Research - June 26, 2021 Category: Research Source Type: research

FK506 ameliorates osteoporosis caused by osteoblast apoptosis via suppressing the activated CaN/NFAT pathway during oxidative stress
ConclusionFK-506 ameliorates osteoporosis resulted from osteoblastic apoptosis which caused by suppressing the activated CaN/NFAT pathway during oxidative stress. (Source: Inflammation Research)
Source: Inflammation Research - June 24, 2021 Category: Research Source Type: research

The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as coronavirus disease 2019 (COVID-19) causes cytokine release syndrome (CRS), leading to acute respiratory distress syndrome (ARDS), acute kidney and cardiac injury, liver dysfunction, and multiorgan failure. Although several studies have discussed the role of 5-lipoxygenase (5-LOX) in viral infections, such as influenzae and SARS, it remains unexplored in the pathophysiology of COVID-19. 5-LOX acts on free arachidonic acid (AA) to form proinflammatory leukotrienes (LTs). Of note, numerous cells involved with COVID-19 (e.g., inflammatory...
Source: Inflammation Research - June 4, 2021 Category: Research Source Type: research

Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report
AbstractLong-term and rare adverse effects of COVID-19 vaccines are unknown. Hence, it is important to report them to improve the safety profile of the vaccines and enhance their use worldwide. Here, we  describes a case of acute visual impairment after Pfizer-BioNTech vaccine second dose.  (Source: Inflammation Research)
Source: Inflammation Research - June 4, 2021 Category: Research Source Type: research

Insight into the longitudinal relationship between chronic subclinical inflammation and obesity from adolescence to early adulthood: a dual trajectory analysis
ConclusionsThese findings support that chronic sub-clinical inflammation is present through adolescence into early adulthood in some individuals. Targeting chronic sub-clinical inflammation though obesity prevention strategies may be important for improving future health outcomes. (Source: Inflammation Research)
Source: Inflammation Research - June 2, 2021 Category: Research Source Type: research

FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1 β signaling pathway in mice and macrophages
ConclusionsThe study results showed that FSTL1 played an important role in allergic airway inflammation by activating NLRP3/IL-1 β. Hence, inhibition FSTL1 could be applied as a therapeutic agent against asthma. (Source: Inflammation Research)
Source: Inflammation Research - June 2, 2021 Category: Research Source Type: research

Molecular insights into phytochemicals exhibiting anti-arthritic activity: systematic review
AbstractIntroductionRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with an unclear etiology causing severe inflammation, joint pain, and destruction that increases the chance of disability over time. Dysregulation of various immune signaling cascades regulates the formation of synovial hyperplasia and pannus formation. Imbalance in cytokine levels, predominantly proinflammatory cytokines like TNF- α, IL-1, IL-6, IL-17, and IL-12p70 profoundly influences the disease's pathogenesis. Even though various strategies are adopted to treat arthritis, their side effects and cost limit their usage. This...
Source: Inflammation Research - May 24, 2021 Category: Research Source Type: research

Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models
ConclusionsTaken together, we evidenced that targeting the hsa_circ_0000520/miR-556-5p/NLRP3 signaling pathway was a novel AQ1strategy to ameliorate AR progression; however, future clinical data are still required to validate our preliminary results. (Source: Inflammation Research)
Source: Inflammation Research - May 24, 2021 Category: Research Source Type: research

Luteolin alleviates ulcerative colitis through SHP-1/STAT3 pathway
ConclusionWe found that the treatment of Luteolin promoted epithelial barrier function and Luteolin might preserve intestinal epithelial barrier function through suppression of STAT3 signaling pathway by SHP-1. (Source: Inflammation Research)
Source: Inflammation Research - May 20, 2021 Category: Research Source Type: research

Are chimeric antigen receptor T cells (CAR-T cells) the future in immunotherapy for autoimmune diseases?
ConclusionsAlthough information in humans is not yet available, preclinical models of CAR-T cells in the treatment of autoimmune diseases show promising results, so that in the future, they may become a useful and effective therapy in the treatment of these pathologies. (Source: Inflammation Research)
Source: Inflammation Research - May 20, 2021 Category: Research Source Type: research

Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1
ConclusionThis study is the first to prove that silencing circANKRD36 inhibits STZ-induced insulin resistance and inflammation in diabetic rats by targeting miR- 145 via XBP1. The results warrant the importance of circRNAs as drug target and thereby pave way for the development of newer therapeutic measures for T2DM. (Source: Inflammation Research)
Source: Inflammation Research - May 12, 2021 Category: Research Source Type: research

A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19
ConclusionThe inflammation-based risk scoring system predicts the need for mechanical ventilation in patients with severe COVID-19. (Source: Inflammation Research)
Source: Inflammation Research - May 10, 2021 Category: Research Source Type: research

Circulating calprotectin as a supporting inflammatory marker in discriminating SARS-CoV-2 infection: an observational study
ConclusionsOur data propose circulating calprotectin as a new, quantitative and predictive marker, which in addition to being an interesting generic inflammatory marker may provide important indications in SARS-CoV-2 infection. (Source: Inflammation Research)
Source: Inflammation Research - May 6, 2021 Category: Research Source Type: research

Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target
ConclusionWe propose several ways to modulate the purinergic system as a potential therapy for CF, like inhibition of P2X7, activation of P2Y2, A2A and A2B receptors and blocking of adenosine deaminase. Among them, we postulate that the most suitable strategy is to block the action of adenosine deaminase, which culminates in the increase of Ado levels that presents anti-inflammatory actions and improves mucociliary clearance. Furthermore, it is possible to maintain the physiological levels of ATP to control the hydration of ASL. These therapies could correct the main mechanisms that contribute to the progression of CF. (So...
Source: Inflammation Research - April 27, 2021 Category: Research Source Type: research

Stability of housekeeping genes in inflamed joints of spontaneous and collagen-induced arthritis in DBA/1 mice
ConclusionThis study demonstrates that commonly used reference genes may not be suitable for arthritic tissues from DBA/1 mice, and strengthening the principle that meticulous validation of reference genes is essential before each experiment to obtain valid and reproducible qPCR data for analysis or interpretation. (Source: Inflammation Research)
Source: Inflammation Research - April 26, 2021 Category: Research Source Type: research