Tricarboxylic acid cycle metabolites: new players in macrophage
AbstractMetabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for...
Source: Inflammation Research - March 18, 2024 Category: Research Source Type: research

The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target
ConclusionsCD38 and NAD+ depletion are druggable targets controlling the MSU crystal- induced inflammation program. Targeting CD38 and NAD+ are potentially novel selective molecular approaches to limit gouty arthritis. (Source: Inflammation Research)
Source: Inflammation Research - March 16, 2024 Category: Research Source Type: research

Bridging the divide: unveiling mutual immunological pathways of cancer and pregnancy
AbstractThe juxtaposition of two seemingly disparate physiological phenomena within the human body —namely, cancer and pregnancy—may offer profound insights into the intricate interplay between malignancies and the immune system. Recent investigations have unveiled striking similarities between the pivotal processes underpinning fetal implantation and successful gestation and those governing tumor initiation and progression. Notably, a confluence of features has emerged, underscoring parallels between the microenvironment of tumors and the maternal–fetal interface. These shared attributes encompass establishing vascu...
Source: Inflammation Research - March 16, 2024 Category: Research Source Type: research

Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults
ConclusionThere existed a substantial association of SII and SIRI levels with CKD prevalence, as well as mortality in patients with CKD in the U.S. population. (Source: Inflammation Research)
Source: Inflammation Research - March 15, 2024 Category: Research Source Type: research

Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons
ConclusionInflammation-associated mechanical allodynia and spontaneous pain in the elderly can be more effectively treated by inhibiting ASIC3 than Nav1.8. (Source: Inflammation Research)
Source: Inflammation Research - March 14, 2024 Category: Research Source Type: research

Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation
ConclusionsThe research findings indicate that ACSL4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation play a crucial regulatory role in the immune response of asthma. This discovery holds promise for enhancing our understanding of the mechanisms underlying asthma pathogenesis and potentially identifying novel targets for its prevention and treatment. (Source: Inflammation Research)
Source: Inflammation Research - March 12, 2024 Category: Research Source Type: research

Imbalance of T  follicular helper cell subsets trigger the differentiation of pathogenic B cells in idiopathic membranous nephropathy
ConclusionsCollectively, our results demonstrate that the imbalance of cTfh cell subsets play a crucial pathogenic role in IMN by inducing the differentiation of B cells through IL-21, and cTfh2 cells might serve as useful markers to evaluate the progression of IMN. (Source: Inflammation Research)
Source: Inflammation Research - March 11, 2024 Category: Research Source Type: research

Genetic correlations, shared risk genes and immunity landscapes between COVID-19 and venous thromboembolism: evidence from GWAS and bulk transcriptome data
ConclusionsCollectively, our results highlighted the significant correlations between COVID-19 and VTE and pinpointed TP53I3 and SLPI as hub genes that potentially link the severity of both conditions. The hub genes and their common regulators might present an opportunity for the simultaneous treatment of these two diseases. (Source: Inflammation Research)
Source: Inflammation Research - March 3, 2024 Category: Research Source Type: research

SS-31 inhibits mtDNA –cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
ConclusionsSS-31 conferred neuroprotection against POCD by promoting PHB2-mediated mitophagy activation to inhibit mtDNA release, which in turn suppressed the cGAS –STING pathway and M1 microglial polarization. (Source: Inflammation Research)
Source: Inflammation Research - February 27, 2024 Category: Research Source Type: research

Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction
ConclusionsCollectively, these studies reveal VMP1 as a negative regulator of inflammatory responses, and we postulate that decreased expression of VMP1 can aggravate the inflammatory sequelae associated with neurodegenerative diseases like PD. (Source: Inflammation Research)
Source: Inflammation Research - February 27, 2024 Category: Research Source Type: research

Interleukin-19 enhances eosinophil infiltration through upregulation of epithelium-derived RANTES expression via the ERK/NF- κB signalling pathway in patients with eosinophilic CRSwNP
ConclusionsOur findings indicate that IL-19 promotes RANTES expression via the ERK/NF- κB pathway in HNECs and is implicated in eosinophil infiltration in patients with Eos CRSwNP. (Source: Inflammation Research)
Source: Inflammation Research - February 23, 2024 Category: Research Source Type: research

Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps
ConclusionsINPP4A deficiency promotes macrophage polarization towards the M2 phenotype, leading to the secretion of chemokines that recruit eosinophils and Th2 cells, thereby amplifying eosinophilic inflammation in E-CRSwNP. INPP4A may exert a suppressive role in eosinophilic inflammation and could potentially serve as a novel therapeutic strategy. (Source: Inflammation Research)
Source: Inflammation Research - February 16, 2024 Category: Research Source Type: research

Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome
ConclusionsCBL0137 alone or plus inflammatory stimulation induces PANoptosis both in vitro and in vivo, which is associated with systemic inflammatory responses in mice. (Source: Inflammation Research)
Source: Inflammation Research - February 14, 2024 Category: Research Source Type: research

Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice
ConclusionsThese findings reveal that anti-CD20 mAb treatment alleviates Th2 cell responses, possibly by depleting lung FM B cells in a Th2-driven asthma model. This implies a potential therapeutic approach for asthma treatment through the targeting of lung FM B cells. (Source: Inflammation Research)
Source: Inflammation Research - February 12, 2024 Category: Research Source Type: research

Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models
ConclusionThe latest strides made in research about intestinal organoids help elucidate intricate aspects of IBD pathogenesis, and pave the prospective avenues for novel therapeutic interventions. (Source: Inflammation Research)
Source: Inflammation Research - February 12, 2024 Category: Research Source Type: research