A spotlight on underlying the mechanism of AMPK in diabetes complications
ConclusionFrom the available information, it may be concluded that various indirect/direct activators show tremendous potential in maintaining the homeostasis of glucose and lipid metabolism, without resulting in insulin resistance, and may improve insulin sensitivity, as well. Therefore, in a nut shell, it may be concluded that the regulation of APMK functions by various direct/indirect activators may bring promising results. These activators may emerge as a novel therapy in diabetes and its associated complications. (Source: Inflammation Research)
Source: Inflammation Research - July 28, 2021 Category: Research Source Type: research

SARS-CoV-2 and pathological matrix remodeling mediators
ConclusionTargeting MMPs and their inhibitors could be a probable solution for occurred events since there are many cured patients that remain with severe sequels even after the end of infection. (Source: Inflammation Research)
Source: Inflammation Research - July 20, 2021 Category: Research Source Type: research

MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer
ConclusionOur results suggest thatMIR452 regulates STAT3 through the IL20RA-mediated JAK1 pathway, but not STAT1. Overall,MIR452 acts as tumor suppressor in human CRC and in a mouse colitis model. These findings suggest thatMIR452 is a promising therapeutic target in the treatment of cancer and colitis. (Source: Inflammation Research)
Source: Inflammation Research - July 20, 2021 Category: Research Source Type: research

The pathophysiology of immunoporosis: innovative therapeutic targets
ConclusionThis review presents alternative pathways in the pathophysiology of osteoporosis, along with some recent therapeutic breakthroughs to restore bone homeostasis. (Source: Inflammation Research)
Source: Inflammation Research - July 16, 2021 Category: Research Source Type: research

Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy
ConclusionThese results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury. (Source: Inflammation Research)
Source: Inflammation Research - July 10, 2021 Category: Research Source Type: research

Pseudomonas aeruginosa outer membrane vesicles ameliorates lung ischemia –reperfusion injury by regulating the balance of regulatory T cells and Th17 cells through Tim-3 and TLR4/NF-κB pathway
ConclusionsThese results suggest that OMVs preconditioning may ameliorate lung I/R injury by regulating the balance of Tregs and Th17 cells through Tim-3 and TLR4/NF- κB pathway. (Source: Inflammation Research)
Source: Inflammation Research - July 5, 2021 Category: Research Source Type: research

CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis
In conclusion, circ-ITCH alleviated renal inflammation and fibrosis in STZ-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis.Author names: Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 1 Given name: [ChunYang] Last name [Xu]. Author 2 Given name: [DingBo] Last name [Xu]. Author 3 Given name: [YongHua] Last name [Liu]. Author 4 Given name: [Juanjuan] Last name [Jiang]. Also, kindly confirm the details in the metadata are correct.ok (Source: Inflammation Research)
Source: Inflammation Research - July 3, 2021 Category: Research Source Type: research

Mechanistic and physiological approaches of fecal microbiota transplantation in the management of NAFLD
AbstractNon-alcoholic fatty liver disease (NAFLD) is a multifaceted disease allied with various metabolic disorders, obesity and dysbiosis. Gut microbiota plays an influential role in the pathogenesis of NAFLD and other metabolic disorders. However, recent scientific upsurge emphasizes on the utility of beneficial gut microbiota and bacteriotherapy in the management of NAFLD. Fecal microbiota transplantation (FMT) is the contemporary therapeutic approach with state-of-the-art methods for the treatment of NAFLD. Other potential therapies include probiotics and prebiotics supplements which are based on alteration of gut micr...
Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research

Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells
ConclusionsThus, our data suggest that caspase-1, IL-1 β and IL-18 may contribute to the inflammatory status observed in SCA and that HU treatment may not interfere in this inflammatory pathway. (Source: Inflammation Research)
Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research

Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease
AbstractJanus kinase/signal transduction and transcriptional activator (JAK/STAT) signaling pathway is a transport hub for cytokine secretion and exerts its effects. The activation of JAK/STAT signaling pathway is essential for the regulation of inflammatory responses. Inappropriate activation or deletion of JAK/STAT signaling pathway is the initiator of the inflammatory response. JAK/STAT signaling pathway has been demonstrated to be involved in the process of innate and adaptive immune response to inflammatory bowel disease (IBD). In this review, we discuss the role of the JAK/STAT signaling pathway in the regulation of ...
Source: Inflammation Research - July 1, 2021 Category: Research Source Type: research

Mechanism of bone marrow mesenchymal stem cells secreting miR-26a exosomes affecting high glucose-induced skin fibroblasts function by regulating TLR4/NF- κB signaling
ConclusionThese results suggest that hMSCs cells secreting miR-26a exosomes inhibited the proliferation, migration, and transdifferentiation of high glucose-induced BJ cells, and promoted cell apoptosis, which may be related to the TLR4/NF- κB signaling pathway. (Source: Inflammation Research)
Source: Inflammation Research - June 29, 2021 Category: Research Source Type: research

Evolution of β-catenin-independent Wnt–GSK3–mTOR signalling in regulation of energy metabolism in isoproterenol-induced cardiotoxicity model
ConclusionWe hereby discuss a novel therapeutic role of the β-catenin independent, Wnt–GSK3–mTOR axis in attenuation of Iso-induced cardiotoxicity in rodents. (Source: Inflammation Research)
Source: Inflammation Research - June 29, 2021 Category: Research Source Type: research

How could perfluorocarbon affect cytokine storm and angiogenesis in coronavirus disease 2019 (COVID-19): role of hypoxia-inducible factor 1 α
AbstractCoronavirus disease 2019 (COVID-19) pandemic is still a world-class challenge. Inflammation, especially its severe form with excess release of pro-inflammatory cytokines (cytokine storm) which is a life-threatening condition, is among the most important suspects involved in COVID-19 pathogenesis. It has been shown that cytokine storm could cause notable morbidities such as acute respiratory distress syndrome (ARDS) which leads to hypoxia which is significantly associated with mortality of patients with COVID-19. Hypoxia-inducible factor 1 α (HIF-1α) which activates following ARDS-induced hypoxia plays a...
Source: Inflammation Research - June 26, 2021 Category: Research Source Type: research

FK506 ameliorates osteoporosis caused by osteoblast apoptosis via suppressing the activated CaN/NFAT pathway during oxidative stress
ConclusionFK-506 ameliorates osteoporosis resulted from osteoblastic apoptosis which caused by suppressing the activated CaN/NFAT pathway during oxidative stress. (Source: Inflammation Research)
Source: Inflammation Research - June 24, 2021 Category: Research Source Type: research

The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as coronavirus disease 2019 (COVID-19) causes cytokine release syndrome (CRS), leading to acute respiratory distress syndrome (ARDS), acute kidney and cardiac injury, liver dysfunction, and multiorgan failure. Although several studies have discussed the role of 5-lipoxygenase (5-LOX) in viral infections, such as influenzae and SARS, it remains unexplored in the pathophysiology of COVID-19. 5-LOX acts on free arachidonic acid (AA) to form proinflammatory leukotrienes (LTs). Of note, numerous cells involved with COVID-19 (e.g., inflammatory...
Source: Inflammation Research - June 4, 2021 Category: Research Source Type: research

Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report
AbstractLong-term and rare adverse effects of COVID-19 vaccines are unknown. Hence, it is important to report them to improve the safety profile of the vaccines and enhance their use worldwide. Here, we  describes a case of acute visual impairment after Pfizer-BioNTech vaccine second dose.  (Source: Inflammation Research)
Source: Inflammation Research - June 4, 2021 Category: Research Source Type: research

Insight into the longitudinal relationship between chronic subclinical inflammation and obesity from adolescence to early adulthood: a dual trajectory analysis
ConclusionsThese findings support that chronic sub-clinical inflammation is present through adolescence into early adulthood in some individuals. Targeting chronic sub-clinical inflammation though obesity prevention strategies may be important for improving future health outcomes. (Source: Inflammation Research)
Source: Inflammation Research - June 2, 2021 Category: Research Source Type: research

FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1 β signaling pathway in mice and macrophages
ConclusionsThe study results showed that FSTL1 played an important role in allergic airway inflammation by activating NLRP3/IL-1 β. Hence, inhibition FSTL1 could be applied as a therapeutic agent against asthma. (Source: Inflammation Research)
Source: Inflammation Research - June 2, 2021 Category: Research Source Type: research

Molecular insights into phytochemicals exhibiting anti-arthritic activity: systematic review
AbstractIntroductionRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with an unclear etiology causing severe inflammation, joint pain, and destruction that increases the chance of disability over time. Dysregulation of various immune signaling cascades regulates the formation of synovial hyperplasia and pannus formation. Imbalance in cytokine levels, predominantly proinflammatory cytokines like TNF- α, IL-1, IL-6, IL-17, and IL-12p70 profoundly influences the disease's pathogenesis. Even though various strategies are adopted to treat arthritis, their side effects and cost limit their usage. This...
Source: Inflammation Research - May 24, 2021 Category: Research Source Type: research

Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models
ConclusionsTaken together, we evidenced that targeting the hsa_circ_0000520/miR-556-5p/NLRP3 signaling pathway was a novel AQ1strategy to ameliorate AR progression; however, future clinical data are still required to validate our preliminary results. (Source: Inflammation Research)
Source: Inflammation Research - May 24, 2021 Category: Research Source Type: research

Luteolin alleviates ulcerative colitis through SHP-1/STAT3 pathway
ConclusionWe found that the treatment of Luteolin promoted epithelial barrier function and Luteolin might preserve intestinal epithelial barrier function through suppression of STAT3 signaling pathway by SHP-1. (Source: Inflammation Research)
Source: Inflammation Research - May 20, 2021 Category: Research Source Type: research

Are chimeric antigen receptor T cells (CAR-T cells) the future in immunotherapy for autoimmune diseases?
ConclusionsAlthough information in humans is not yet available, preclinical models of CAR-T cells in the treatment of autoimmune diseases show promising results, so that in the future, they may become a useful and effective therapy in the treatment of these pathologies. (Source: Inflammation Research)
Source: Inflammation Research - May 20, 2021 Category: Research Source Type: research

Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1
ConclusionThis study is the first to prove that silencing circANKRD36 inhibits STZ-induced insulin resistance and inflammation in diabetic rats by targeting miR- 145 via XBP1. The results warrant the importance of circRNAs as drug target and thereby pave way for the development of newer therapeutic measures for T2DM. (Source: Inflammation Research)
Source: Inflammation Research - May 12, 2021 Category: Research Source Type: research

A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19
ConclusionThe inflammation-based risk scoring system predicts the need for mechanical ventilation in patients with severe COVID-19. (Source: Inflammation Research)
Source: Inflammation Research - May 10, 2021 Category: Research Source Type: research

Circulating calprotectin as a supporting inflammatory marker in discriminating SARS-CoV-2 infection: an observational study
ConclusionsOur data propose circulating calprotectin as a new, quantitative and predictive marker, which in addition to being an interesting generic inflammatory marker may provide important indications in SARS-CoV-2 infection. (Source: Inflammation Research)
Source: Inflammation Research - May 6, 2021 Category: Research Source Type: research

Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target
ConclusionWe propose several ways to modulate the purinergic system as a potential therapy for CF, like inhibition of P2X7, activation of P2Y2, A2A and A2B receptors and blocking of adenosine deaminase. Among them, we postulate that the most suitable strategy is to block the action of adenosine deaminase, which culminates in the increase of Ado levels that presents anti-inflammatory actions and improves mucociliary clearance. Furthermore, it is possible to maintain the physiological levels of ATP to control the hydration of ASL. These therapies could correct the main mechanisms that contribute to the progression of CF. (So...
Source: Inflammation Research - April 27, 2021 Category: Research Source Type: research

Stability of housekeeping genes in inflamed joints of spontaneous and collagen-induced arthritis in DBA/1 mice
ConclusionThis study demonstrates that commonly used reference genes may not be suitable for arthritic tissues from DBA/1 mice, and strengthening the principle that meticulous validation of reference genes is essential before each experiment to obtain valid and reproducible qPCR data for analysis or interpretation. (Source: Inflammation Research)
Source: Inflammation Research - April 26, 2021 Category: Research Source Type: research

FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy
ConclusionFOXO3a could promote lipid accumulation and inflammation in differentiated 3T3-L1 adipocytes by targeting autophagy. Our results provide a new theoretical basis for FOXO3a to regulate obesity. (Source: Inflammation Research)
Source: Inflammation Research - April 23, 2021 Category: Research Source Type: research

Glycine is a competitive antagonist of the TNF receptor mediating the expression of inflammatory cytokines in 3T3-L1 adipocytes
ConclusionThese findings support the idea that glycine could partially inhibit the binding of TNF- α to its receptor and provide clues about the mechanisms by which glycine inhibits the secretion of pro-inflammatory adipokines in adipocytes through the TNF-α receptor. (Source: Inflammation Research)
Source: Inflammation Research - April 20, 2021 Category: Research Source Type: research

Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis
ConclusionsThese data demonstrated that H2 is efficient in suppressing allergen-induced asthma and could be developed as a therapeutics for asthma and other conditions of type II inflammation. (Source: Inflammation Research)
Source: Inflammation Research - April 14, 2021 Category: Research Source Type: research

Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis
ConclusionDisulfiram can inhibit inflammation and fibrosis in renal fibrosis rats by inhibiting GSDMD. (Source: Inflammation Research)
Source: Inflammation Research - April 13, 2021 Category: Research Source Type: research

Sublingual immunotherapy for 4  years increased the number of Foxp3 + Treg cells, which correlated with clinical effects
ConclusionsThese results suggest that 4  years of SLIT is needed to achieve sustained increases in Foxp3+ Treg cells, which are closely associated with the efficacy of SLIT. (Source: Inflammation Research)
Source: Inflammation Research - April 9, 2021 Category: Research Source Type: research

Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice
ConclusionThese results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders. (Source: Inflammation Research)
Source: Inflammation Research - April 3, 2021 Category: Research Source Type: research

Complement regulation in tenocytes under the influence of leukocytes in an indirect co-culture model
ConclusionTNF α might represent a crucial soluble mediator exerting diverse time-dependent effects on tenocyte complement regulation. (Source: Inflammation Research)
Source: Inflammation Research - March 27, 2021 Category: Research Source Type: research

Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells
ConclusionsIn conclusion, TWEAK/Fn14 signals contributed to tubulointerstitial fibrosis by acting on proximal tubular epithelial cells.Fn14 inhibition might be a therapeutic strategy for protecting against renal interstitial fibrosis. (Source: Inflammation Research)
Source: Inflammation Research - March 23, 2021 Category: Research Source Type: research

Association of alpha-1-antitrypsin deficiency with vitamin D status: who is most at risk of getting severe COVID-19?
ConclusionTherefore, early vitamin D and AAT assessments and optimal interventions could be helpful to prevent severe COVID-19 outcomes. (Source: Inflammation Research)
Source: Inflammation Research - March 19, 2021 Category: Research Source Type: research

Polarity scaffolds signaling in epithelial cell permeability
AbstractAs an integral part of the innate immune system, the epithelial membrane is exposed to an array of insults that may trigger an immune response. One of the immune system ’s main functions is to regulate the level of communications between the mucosa and the lumen of various tissues. While it is clear that inhaled or ingested substances, or microorganisms may induce changes that affect the epithelial barrier in various ways, the proteins involved in the signaling c ascades and physiological events leading to the regulation and maintenance of the barrier are not always well characterized. We review here some of ...
Source: Inflammation Research - March 15, 2021 Category: Research Source Type: research

Altered sensory innervation and pain hypersensitivity in a model of young painful arthritic joints: short- and long-term effects
ConclusionsJoint inflammation increases the sensory nociceptive innervation and induces acute pain hypersensitivity in juvenile and adult, but not in young rats. However, early life joint inflammation ‘primes’ the joint such that adult inflammatory pain behaviour and nociceptive nerve endings in the joint are significantly increased. Early life joint inflammation may be an important factor in the generation and maintenance of chronic arthritic pain. (Source: Inflammation Research)
Source: Inflammation Research - March 13, 2021 Category: Research Source Type: research

Propofol regulates activated macrophages metabolism through inhibition of ROS-mediated GLUT1 expression
ConclusionThese findings shed light on the function and mechanism of propofol in the metabolic switch and highlight the importance of targeting metabolism by propofol in the clinical medication of inflammatory diseases. (Source: Inflammation Research)
Source: Inflammation Research - March 9, 2021 Category: Research Source Type: research

Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction
ConclusionIn the current review, we focus on the role of mitochondrial dysfunction and other mitochondria-related mechanisms including immunologic  imbalance, energetic reprogramming, mitophagy, and pyroptosis in the mechanisms of SIMD. (Source: Inflammation Research)
Source: Inflammation Research - March 8, 2021 Category: Research Source Type: research

Association of IL-10 -1082A & gt;G, -819C & gt;T, and -592C & gt;A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis
ConclusionsThe current meta-analysis showed that the IL-10 -592C>A polymorphism was statistically associated with periodontitis risk in the overall population. Moreover, the IL-10 -1082A>G, IL-10 -819C>T, and IL-10 -592C>A polymorphisms were associated with periodontitis risk by ethnicity. Therefore, the IL-10 polymorphisms are of high clinical relevance by ethnicity and would be a useful marker to identify patients who are at higher risk for periodontitis. (Source: Inflammation Research)
Source: Inflammation Research - March 5, 2021 Category: Research Source Type: research

COVID-19 illness and autoimmune diseases: recent insights
ConclusionThe relationship between autoimmune diseases and SARS-CoV-2 infection is complex. During the COVID-19 epidemic, individualized interventions for AIDs should be provided such as Internet-based service. (Source: Inflammation Research)
Source: Inflammation Research - February 28, 2021 Category: Research Source Type: research

PAX5 activates telomerase activity and proliferation in keloid fibroblasts by transcriptional regulation of SND1, thus promoting keloid growth in burn-injured skin
ConclusionSND1 transcriptionally regulated by PAX5 promotes keloid formation through activating telomerase activity via the ERK/JNK signaling pathways, which provides a promising therapeutic target for clinical treatment of burned skin keloid. (Source: Inflammation Research)
Source: Inflammation Research - February 22, 2021 Category: Research Source Type: research

MicroRNA-301a-3p promotes diabetic retinopathy via regulation of six-transmembrane epithelial antigen of prostate 4
ConclusionmiR-301a-3p promotes diabetic retinopathy via regulation of STEAP4. The findings in this study may provide a vital reference for the drug research and development in DR treatment. (Source: Inflammation Research)
Source: Inflammation Research - February 20, 2021 Category: Research Source Type: research

Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection
ConclusionIt is suggested that immunosuppressants, such as anti-rheumatoid drugs, could be considered as a potential approach for the treatment of cytokine storm in severe cases of COVID-19. One possible limitation of immunosuppressant therapy is their inhibitory effects on host anti-viral immune response. So, the appropriate timing of administration should be carefully considered. (Source: Inflammation Research)
Source: Inflammation Research - February 19, 2021 Category: Research Source Type: research

Manifestation of lipopolysaccharide-induced tolerance in neuro-glial primary cultures of the rat afferent somatosensory system
ConclusionA state of LPS tolerance can be induced in primary cultures from the afferent somatosensory system, which is characterized by a down-regulation of pro-inflammatory mediators. Thus, this model can be applied to study the effects of LPS tolerance at the cellular level, for example possible modifications of neuronal reactivity patterns upon inflammatory stimulation. (Source: Inflammation Research)
Source: Inflammation Research - February 13, 2021 Category: Research Source Type: research

Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults
ConclusionAnti-inflammatory potential of dietary ACN in T2D participants was evidenced in the present study. Although, anti-inflammatory dietary patterns of T2D participants may have accelerated the anti-inflammatory effect of the ACN capsules supplemented in this trial. (Source: Inflammation Research)
Source: Inflammation Research - February 12, 2021 Category: Research Source Type: research

Activated M1 macrophages suppress c-kit expression via TNF- α -mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis
ConclusionMacrophages activation in NEC intestine results in an increased inflammatory response and TNF-α production, accompanied with miR-222 upregulation and c-kit suppression. Modulations of M1 macrophages, TNF-α or miR-222 may be potential therapeutic targets for NEC treatment. (Source: Inflammation Research)
Source: Inflammation Research - February 10, 2021 Category: Research Source Type: research

Therapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice
ConclusionThe anti-inflammatory benefits of DHA treatment depend upon the type of inflammatory particle, magnitude of inflammation, and duration of treatment. (Source: Inflammation Research)
Source: Inflammation Research - February 10, 2021 Category: Research Source Type: research

Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis
ConclusionTrip regulates macrophage polarization through miR-449a/NLRP3 axis and the STAT3/NF- κB pathway to mitigate GA. The elucidation on the molecular mechanism of Trip in GA may provide theoretical guidance for clinical therapy of GA. (Source: Inflammation Research)
Source: Inflammation Research - February 9, 2021 Category: Research Source Type: research