Transient Receptor Potential Vanilloid-1 (TRPV1) Channels act as Suppressors of the Growth of Glioma
Brain Res Bull. 2024 Apr 15:110950. doi: 10.1016/j.brainresbull.2024.110950. Online ahead of print.ABSTRACTThe aim of this study was to investigate the expression and function of the transient receptor potential vanilloid 1 (TRPV1) in glioma. We found that the expression of TRPV1 mRNA and protein were upregulated in glioma compared with normal brain by qPCR and western blot analysis. In order to investigate the function of TRPV1 in glioma, short hairpin RNA (shRNA) and the inhibitor of TRPV1 were used. In vitro, the activation of TRPV1 induced cell apoptosis with decreased migration capability and inhibited proliferation, ...
Source: Brain Research - April 17, 2024 Category: Neurology Authors: Jingjing Cheng Mengliu Zeng Biwen Peng Ping Li ShiYu Zhao Source Type: research
Alterations in the brain serotonin system and serotonin-regulated behavior during aging in zebrafish males and females
Behav Brain Res. 2024 Apr 15:115000. doi: 10.1016/j.bbr.2024.115000. Online ahead of print.ABSTRACTThe brain serotonin (5-HT) system performs a neurotrophic function and supports the plasticity of the nervous system, while its age-related changes can increase the risk of senile neurodegeneration. Zebrafish brain is highly resistant to damage and neurodegeneration due to its high regeneration potential and it is a promising model object in searching for molecular factors preventing age-related neurodegeneration. In the present study alterations in 5-HT-related behavior in the home tank and the novel tank diving test, as wel...
Source: Brain Research - April 17, 2024 Category: Neurology Authors: Valentina S Evsiukova Ivan E Sorokin Peter A Kulikov Alexander V Kulikov Source Type: research
Neural responses to gaming content on social media in young adults
Behav Brain Res. 2024 Apr 15:115004. doi: 10.1016/j.bbr.2024.115004. Online ahead of print.ABSTRACTExcessive gaming can impair both mental and physical health, drawing widespread public and clinical attention, especially among young generations. People are now more exposed to gaming-related content on social media than before, and this exposure may have a significant impact on their behavior. However, the neural mechanisms underlying this effect remain unexplored. Using functional magnetic resonance imaging (fMRI), this study aimed to investigate the neural activity induced by gaming-related content on social media among y...
Source: Brain Research - April 17, 2024 Category: Neurology Authors: Yuka Fujimoto Junya Fujino Daisuke Matsuyoshi Daisuke Jitoku Nanase Kobayashi Chenyu Qian Shoko Okuzumi Shisei Tei Takehiro Tamura Takefumi Ueno Makiko Yamada Hidehiko Takahashi Source Type: research
EEG complexity in emotion conflict task in individuals with psychiatric disorders
This study highlights the significance of investigating EEG complexity and its potential applications in the transdiagnostic exploration of impulsivity in psychiatric disorders.PMID:38621461 | DOI:10.1016/j.bbr.2024.114997 (Source: Brain Research)
Source: Brain Research - April 15, 2024 Category: Neurology Authors: Chao Gu Tina Chou Alik S Widge Darin D Dougherty Source Type: research
Redundancy effect of initial enactment encoding and subsequent testing on memory enhancement: Insights from an electrophysiological study
In this study, a classical testing effect paradigm was employed, along with event-related potentials (ERP), to investigate the electrophysiological processes underlying the effect of enactment encoding on the testing effect. Participants were randomly assigned to the Self-Performed Test (SPT) or Verbalized Test (VT) groups. Both groups underwent three stages: an initial encoding phase, an initial test phase (comprising a source memory task and a restudy task), and a final test phase. During the initial encoding phase, the SPT group encoded action phrases through enactment, while the VT group encoded information through rea...
Source: Brain Research - April 15, 2024 Category: Neurology Authors: Xiaoyu Cui Jing Lu Yi Liu Juan Li Zhiwei Zheng Chunyan Guo Source Type: research
EEG complexity in emotion conflict task in individuals with psychiatric disorders
This study highlights the significance of investigating EEG complexity and its potential applications in the transdiagnostic exploration of impulsivity in psychiatric disorders.PMID:38621461 | DOI:10.1016/j.bbr.2024.114997 (Source: Brain Research)
Source: Brain Research - April 15, 2024 Category: Neurology Authors: Chao Gu Tina Chou Alik S Widge Darin D Dougherty Source Type: research
Redundancy effect of initial enactment encoding and subsequent testing on memory enhancement: Insights from an electrophysiological study
In this study, a classical testing effect paradigm was employed, along with event-related potentials (ERP), to investigate the electrophysiological processes underlying the effect of enactment encoding on the testing effect. Participants were randomly assigned to the Self-Performed Test (SPT) or Verbalized Test (VT) groups. Both groups underwent three stages: an initial encoding phase, an initial test phase (comprising a source memory task and a restudy task), and a final test phase. During the initial encoding phase, the SPT group encoded action phrases through enactment, while the VT group encoded information through rea...
Source: Brain Research - April 15, 2024 Category: Neurology Authors: Xiaoyu Cui Jing Lu Yi Liu Juan Li Zhiwei Zheng Chunyan Guo Source Type: research
Abnormal functional connectivity of white-matter networks and gray-white matter functional networks in patients with NMOSD
Brain Res Bull. 2024 Apr 12:110949. doi: 10.1016/j.brainresbull.2024.110949. Online ahead of print.ABSTRACTCognitive impairment (CI) has been reported in 29-70% of patients with neuromyelitis optica spectrum disorder (NMOSD). Abnormal white matter (WM) functional networks that correlate with cognitive functions have not been studied well in patients with NMOSD. The aim of the current study was to investigate functional connectivity (FC), spontaneous activity, and functional covariance connectivity (FCC) abnormalities of WM functional networks in patients with NMOSD and their correlation with cognitive performance. Twenty-f...
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Xincui Wan Yingjie Tang Yu Wu Zhenming Xu Wangsheng Chen Feng Chen Cheng Luo Fei Wang Source Type: research
The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats
In this study, we aimed to investigate the long-term effects of ND and caffeine, either alone or in combination, on passive avoidance memory and nociception. We used the step-down and hot-plate tasks in male and female Lister Hooded rats. Our results confirmed the antinociceptive effect of caffeine and indicated that chronic administration of the ND-caffeine association promotes the evocation of aversive memory in female rats.PMID:38615923 | DOI:10.1016/j.brainres.2024.148937 (Source: Brain Research)
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Daniel Bussinger de Souza Penna Samara Gumi éro Costa Alexandre Dos Santos-Rodrigues Pablo Pandolfo Source Type: research
Deciphering the role of brainstem glycinergic neurons during startle and prepulse inhibition
This study highlights the importance of GlyT2± PnC neurons in PPI and underscores their diminished activity in age-related PPI decline.PMID:38615924 | DOI:10.1016/j.brainres.2024.148938 (Source: Brain Research)
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Wanyun Huang Jose C Cano Karine F énelon Source Type: research
Prelimbic Cortex-Nucleus Accumbens Core Projection Positively Regulates Itch and Itch-Related Aversion
In this study, rat models of acute neck and cheek itch were established by subcutaneous injection of 5-HT, compound 48/80, or chloroquine. Immunofluorescence experiments determined that the number of c-Fos-immunopositive neurons in the Prl increased during acute itch. Chemogenetic inhibition of Prl glutamatergic neurons or Prl-NAcC glutamatergic projections can inhibit both histaminergic and nonhistaminergic itch-scratching behaviors and rectify the itch-related conditioned place aversion (CPA) behavior associated with nonhistaminergic itch. The Prl-NAcC projection may play an important role in the positive regulation of i...
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Jun-Hui Long Pu-Jun Wang Li Xuan Yao Juan Guang-Yan Wu Jun-Fei Teng Jian-Feng Sui Ya-Min Li Liu Yang Hong-Li Li Shu-Lei Liu Source Type: research
Abnormal functional connectivity of white-matter networks and gray-white matter functional networks in patients with NMOSD
Brain Res Bull. 2024 Apr 12:110949. doi: 10.1016/j.brainresbull.2024.110949. Online ahead of print.ABSTRACTCognitive impairment (CI) has been reported in 29-70% of patients with neuromyelitis optica spectrum disorder (NMOSD). Abnormal white matter (WM) functional networks that correlate with cognitive functions have not been studied well in patients with NMOSD. The aim of the current study was to investigate functional connectivity (FC), spontaneous activity, and functional covariance connectivity (FCC) abnormalities of WM functional networks in patients with NMOSD and their correlation with cognitive performance. Twenty-f...
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Xincui Wan Yingjie Tang Yu Wu Zhenming Xu Wangsheng Chen Feng Chen Cheng Luo Fei Wang Source Type: research
The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats
In this study, we aimed to investigate the long-term effects of ND and caffeine, either alone or in combination, on passive avoidance memory and nociception. We used the step-down and hot-plate tasks in male and female Lister Hooded rats. Our results confirmed the antinociceptive effect of caffeine and indicated that chronic administration of the ND-caffeine association promotes the evocation of aversive memory in female rats.PMID:38615923 | DOI:10.1016/j.brainres.2024.148937 (Source: Brain Research)
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Daniel Bussinger de Souza Penna Samara Gumi éro Costa Alexandre Dos Santos-Rodrigues Pablo Pandolfo Source Type: research
Deciphering the role of brainstem glycinergic neurons during startle and prepulse inhibition
This study highlights the importance of GlyT2± PnC neurons in PPI and underscores their diminished activity in age-related PPI decline.PMID:38615924 | DOI:10.1016/j.brainres.2024.148938 (Source: Brain Research)
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Wanyun Huang Jose C Cano Karine F énelon Source Type: research
Prelimbic Cortex-Nucleus Accumbens Core Projection Positively Regulates Itch and Itch-Related Aversion
In this study, rat models of acute neck and cheek itch were established by subcutaneous injection of 5-HT, compound 48/80, or chloroquine. Immunofluorescence experiments determined that the number of c-Fos-immunopositive neurons in the Prl increased during acute itch. Chemogenetic inhibition of Prl glutamatergic neurons or Prl-NAcC glutamatergic projections can inhibit both histaminergic and nonhistaminergic itch-scratching behaviors and rectify the itch-related conditioned place aversion (CPA) behavior associated with nonhistaminergic itch. The Prl-NAcC projection may play an important role in the positive regulation of i...
Source: Brain Research - April 14, 2024 Category: Neurology Authors: Jun-Hui Long Pu-Jun Wang Li Xuan Yao Juan Guang-Yan Wu Jun-Fei Teng Jian-Feng Sui Ya-Min Li Liu Yang Hong-Li Li Shu-Lei Liu Source Type: research
