The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom

Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10.1016/j.toxicon.2024.107711
Source: Toxicon - Category: Toxicology Authors: Source Type: research