The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases
Cell Mol Neurobiol. 2024 Mar 10;44(1):28. doi: 10.1007/s10571-024-01461-w.ABSTRACTClearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding R...
Source: Cellular and Molecular Neurobiology - March 9, 2024 Category: Cytology Authors: Abdolkarim Talebi Taheri Zakieh Golshadi Hamidreza Zare Azam Alinaghipour Zahra Faghihi Ehsan Dadgostar Zeinab Tamtaji Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research

Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research
Cell Mol Neurobiol. 2024 Mar 6;44(1):27. doi: 10.1007/s10571-024-01458-5.ABSTRACTEpilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in st...
Source: Cellular and Molecular Neurobiology - March 5, 2024 Category: Cytology Authors: Wenjie Xiao Peile Li Fujiao Kong Jingyi Kong Aihua Pan Lili Long Xiaoxin Yan Bo Xiao Jiaoe Gong Lily Wan Source Type: research

Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research
Cell Mol Neurobiol. 2024 Mar 6;44(1):27. doi: 10.1007/s10571-024-01458-5.ABSTRACTEpilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in st...
Source: Cellular and Molecular Neurobiology - March 5, 2024 Category: Cytology Authors: Wenjie Xiao Peile Li Fujiao Kong Jingyi Kong Aihua Pan Lili Long Xiaoxin Yan Bo Xiao Jiaoe Gong Lily Wan Source Type: research

Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research
Cell Mol Neurobiol. 2024 Mar 6;44(1):27. doi: 10.1007/s10571-024-01458-5.ABSTRACTEpilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in st...
Source: Cellular and Molecular Neurobiology - March 5, 2024 Category: Cytology Authors: Wenjie Xiao Peile Li Fujiao Kong Jingyi Kong Aihua Pan Lili Long Xiaoxin Yan Bo Xiao Jiaoe Gong Lily Wan Source Type: research

Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research
Cell Mol Neurobiol. 2024 Mar 6;44(1):27. doi: 10.1007/s10571-024-01458-5.ABSTRACTEpilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in st...
Source: Cellular and Molecular Neurobiology - March 5, 2024 Category: Cytology Authors: Wenjie Xiao Peile Li Fujiao Kong Jingyi Kong Aihua Pan Lili Long Xiaoxin Yan Bo Xiao Jiaoe Gong Lily Wan Source Type: research

Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Cell Mol Neurobiol. 2024 Feb 23;44(1):25. doi: 10.1007/s10571-024-01457-6.ABSTRACTFerroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory amino acids, and the inflammatory response after ...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Xinjuan Tian Xiang Li Mengtian Pan Lele Zixin Yang Yunman Li Weirong Fang Source Type: research

Iron Deposition in Parkinson's Disease: A Mini-Review
Cell Mol Neurobiol. 2024 Feb 23;44(1):26. doi: 10.1007/s10571-024-01459-4.ABSTRACTIron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulat...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Weiqi Zeng Jin Cai Lei Zhang Qiwei Peng Source Type: research

Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Cell Mol Neurobiol. 2024 Feb 23;44(1):25. doi: 10.1007/s10571-024-01457-6.ABSTRACTFerroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory amino acids, and the inflammatory response after ...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Xinjuan Tian Xiang Li Mengtian Pan Lele Zixin Yang Yunman Li Weirong Fang Source Type: research

Iron Deposition in Parkinson's Disease: A Mini-Review
Cell Mol Neurobiol. 2024 Feb 23;44(1):26. doi: 10.1007/s10571-024-01459-4.ABSTRACTIron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulat...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Weiqi Zeng Jin Cai Lei Zhang Qiwei Peng Source Type: research