Circ_0007534 Silencing Inhibits the Proliferation, Migration and Invasion and Induces the Apoptosis of Glioma Cells Partly Through Down-Regulating PROX1 Via Elevating miR-22-3p Level
Cell Mol Neurobiol. 2021 Sep 18. doi: 10.1007/s10571-021-01150-y. Online ahead of print.ABSTRACTGlioma is a common malignant brain neoplasm. The role and mechanism of circular RNA 0,007,534 (circ_0007534) in glioma progression were investigated in this study. The expression of circ_0007534, microRNA-22-3p (miR-22-3p) and prospero homeobox protein 1 (PROX1) messenger RNA (mRNA) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation, migration and invasion abilities were analyzed by colony formation assay, transwell migration assay and transwell invasion assay. Cell apoptosis was asse...
Source: Cellular and Molecular Neurobiology - September 18, 2021 Category: Cytology Authors: Yong Zheng Yan Wang Rongkang Mai Liang Liu Zifeng Zhu Yiyao Cao Source Type: research

Circ_0007534 Silencing Inhibits the Proliferation, Migration and Invasion and Induces the Apoptosis of Glioma Cells Partly Through Down-Regulating PROX1 Via Elevating miR-22-3p Level
Cell Mol Neurobiol. 2021 Sep 18. doi: 10.1007/s10571-021-01150-y. Online ahead of print.ABSTRACTGlioma is a common malignant brain neoplasm. The role and mechanism of circular RNA 0,007,534 (circ_0007534) in glioma progression were investigated in this study. The expression of circ_0007534, microRNA-22-3p (miR-22-3p) and prospero homeobox protein 1 (PROX1) messenger RNA (mRNA) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation, migration and invasion abilities were analyzed by colony formation assay, transwell migration assay and transwell invasion assay. Cell apoptosis was asse...
Source: Cellular and Molecular Neurobiology - September 18, 2021 Category: Cytology Authors: Yong Zheng Yan Wang Rongkang Mai Liang Liu Zifeng Zhu Yiyao Cao Source Type: research

Circ_0007534 Silencing Inhibits the Proliferation, Migration and Invasion and Induces the Apoptosis of Glioma Cells Partly Through Down-Regulating PROX1 Via Elevating miR-22-3p Level
Cell Mol Neurobiol. 2021 Sep 18. doi: 10.1007/s10571-021-01150-y. Online ahead of print.ABSTRACTGlioma is a common malignant brain neoplasm. The role and mechanism of circular RNA 0,007,534 (circ_0007534) in glioma progression were investigated in this study. The expression of circ_0007534, microRNA-22-3p (miR-22-3p) and prospero homeobox protein 1 (PROX1) messenger RNA (mRNA) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation, migration and invasion abilities were analyzed by colony formation assay, transwell migration assay and transwell invasion assay. Cell apoptosis was asse...
Source: Cellular and Molecular Neurobiology - September 18, 2021 Category: Cytology Authors: Yong Zheng Yan Wang Rongkang Mai Liang Liu Zifeng Zhu Yiyao Cao Source Type: research

Circ_0007534 Silencing Inhibits the Proliferation, Migration and Invasion and Induces the Apoptosis of Glioma Cells Partly Through Down-Regulating PROX1 Via Elevating miR-22-3p Level
Cell Mol Neurobiol. 2021 Sep 18. doi: 10.1007/s10571-021-01150-y. Online ahead of print.ABSTRACTGlioma is a common malignant brain neoplasm. The role and mechanism of circular RNA 0,007,534 (circ_0007534) in glioma progression were investigated in this study. The expression of circ_0007534, microRNA-22-3p (miR-22-3p) and prospero homeobox protein 1 (PROX1) messenger RNA (mRNA) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation, migration and invasion abilities were analyzed by colony formation assay, transwell migration assay and transwell invasion assay. Cell apoptosis was asse...
Source: Cellular and Molecular Neurobiology - September 18, 2021 Category: Cytology Authors: Yong Zheng Yan Wang Rongkang Mai Liang Liu Zifeng Zhu Yiyao Cao Source Type: research

Correction to: The Histopathology of Severe Graded Compression in Lower Thoracic Spinal Cord Segment of Rat, Evaluated at Late Post-injury Phase
Cell Mol Neurobiol. 2021 Sep 17. doi: 10.1007/s10571-021-01149-5. Online ahead of print.NO ABSTRACTPMID:34533686 | DOI:10.1007/s10571-021-01149-5 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 17, 2021 Category: Cytology Authors: Jana Fedorova Erika Kellerova Katarina Bimbova Jaroslav Pavel Source Type: research

Multiomic Analyses of Dopaminergic Neurons Isolated from Human Substantia Nigra in Parkinson's Disease: A Descriptive and Exploratory Study
Cell Mol Neurobiol. 2021 Sep 15. doi: 10.1007/s10571-021-01146-8. Online ahead of print.ABSTRACTDopaminergic neurons (DA) of the substantia nigra pars compacta (SNpc) selectively and progressively degenerate in Parkinson's disease (PD). Until now, molecular analyses of DA in PD have been limited to genomic or transcriptomic approaches, whereas, to the best of our knowledge, no proteomic or combined multiomic study examining the protein profile of these neurons is currently available. In this exploratory study, we used laser capture microdissection to extract regions from DA in 10 human SNpc obtained at autopsy in PD patien...
Source: Cellular and Molecular Neurobiology - September 16, 2021 Category: Cytology Authors: Affif Zaccaria Paola Antinori Virginie Licker Enik ö Kövari Johannes A Lobrinus Pierre R Burkhard Source Type: research

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Cell Mol Neurobiol. 2021 Sep 13. doi: 10.1007/s10571-021-01147-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized clinically by progressive memory loss and impaired cognitive function. Its progression occurs from neuronal synapse loss to amyloid pathology and Tau deposit which eventually leads to the compromised neuronal function. Neurons in central nervous tissue work in a composite and intricate network with the glia and vascular cells. Microglia and astrocytes are becoming the prime focus due to their involvement in various aspects of neurophysio...
Source: Cellular and Molecular Neurobiology - September 13, 2021 Category: Cytology Authors: Kumari Preeti Anika Sood Valencia Fernandes Source Type: research

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Cell Mol Neurobiol. 2021 Sep 13. doi: 10.1007/s10571-021-01147-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized clinically by progressive memory loss and impaired cognitive function. Its progression occurs from neuronal synapse loss to amyloid pathology and Tau deposit which eventually leads to the compromised neuronal function. Neurons in central nervous tissue work in a composite and intricate network with the glia and vascular cells. Microglia and astrocytes are becoming the prime focus due to their involvement in various aspects of neurophysio...
Source: Cellular and Molecular Neurobiology - September 13, 2021 Category: Cytology Authors: Kumari Preeti Anika Sood Valencia Fernandes Source Type: research

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Cell Mol Neurobiol. 2021 Sep 13. doi: 10.1007/s10571-021-01147-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized clinically by progressive memory loss and impaired cognitive function. Its progression occurs from neuronal synapse loss to amyloid pathology and Tau deposit which eventually leads to the compromised neuronal function. Neurons in central nervous tissue work in a composite and intricate network with the glia and vascular cells. Microglia and astrocytes are becoming the prime focus due to their involvement in various aspects of neurophysio...
Source: Cellular and Molecular Neurobiology - September 13, 2021 Category: Cytology Authors: Kumari Preeti Anika Sood Valencia Fernandes Source Type: research

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Cell Mol Neurobiol. 2021 Sep 13. doi: 10.1007/s10571-021-01147-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized clinically by progressive memory loss and impaired cognitive function. Its progression occurs from neuronal synapse loss to amyloid pathology and Tau deposit which eventually leads to the compromised neuronal function. Neurons in central nervous tissue work in a composite and intricate network with the glia and vascular cells. Microglia and astrocytes are becoming the prime focus due to their involvement in various aspects of neurophysio...
Source: Cellular and Molecular Neurobiology - September 13, 2021 Category: Cytology Authors: Kumari Preeti Anika Sood Valencia Fernandes Source Type: research

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Cell Mol Neurobiol. 2021 Sep 13. doi: 10.1007/s10571-021-01147-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized clinically by progressive memory loss and impaired cognitive function. Its progression occurs from neuronal synapse loss to amyloid pathology and Tau deposit which eventually leads to the compromised neuronal function. Neurons in central nervous tissue work in a composite and intricate network with the glia and vascular cells. Microglia and astrocytes are becoming the prime focus due to their involvement in various aspects of neurophysio...
Source: Cellular and Molecular Neurobiology - September 13, 2021 Category: Cytology Authors: Kumari Preeti Anika Sood Valencia Fernandes Source Type: research

Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
Cell Mol Neurobiol. 2021 Sep 13. doi: 10.1007/s10571-021-01147-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized clinically by progressive memory loss and impaired cognitive function. Its progression occurs from neuronal synapse loss to amyloid pathology and Tau deposit which eventually leads to the compromised neuronal function. Neurons in central nervous tissue work in a composite and intricate network with the glia and vascular cells. Microglia and astrocytes are becoming the prime focus due to their involvement in various aspects of neurophysio...
Source: Cellular and Molecular Neurobiology - September 13, 2021 Category: Cytology Authors: Kumari Preeti Anika Sood Valencia Fernandes Source Type: research

Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!
Cell Mol Neurobiol. 2021 Sep 12. doi: 10.1007/s10571-021-01148-6. Online ahead of print.ABSTRACTOxygen sensing and homeostasis is indispensable for the maintenance of brain structural and functional integrity. Under low-oxygen tension, the non-diseased brain has the ability to cope with hypoxia by triggering a homeostatic response governed by the highly conserved hypoxia-inducible family (HIF) of transcription factors. With the advent of advanced neuroimaging tools, it is now recognized that cerebral hypoperfusion, and consequently hypoxia, is a consistent feature along the Alzheimer's disease (AD) continuum. Of note, the ...
Source: Cellular and Molecular Neurobiology - September 12, 2021 Category: Cytology Authors: S ónia C Correia Paula I Moreira Source Type: research

40 Years of Cellular and Molecular Neurobiology
Cell Mol Neurobiol. 2021 Sep 2:1. doi: 10.1007/s10571-021-01142-y. Online ahead of print.NO ABSTRACTPMID:34476660 | PMC:PMC8412391 | DOI:10.1007/s10571-021-01142-y (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: David O Carpenter Source Type: research

Correction to: Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Sep 3. doi: 10.1007/s10571-021-01143-x. Online ahead of print.NO ABSTRACTPMID:34478003 | DOI:10.1007/s10571-021-01143-x (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

40 Years of Cellular and Molecular Neurobiology
Cell Mol Neurobiol. 2021 Sep 2:1. doi: 10.1007/s10571-021-01142-y. Online ahead of print.NO ABSTRACTPMID:34476660 | PMC:PMC8412391 | DOI:10.1007/s10571-021-01142-y (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: David O Carpenter Source Type: research

Correction to: Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Sep 3. doi: 10.1007/s10571-021-01143-x. Online ahead of print.NO ABSTRACTPMID:34478003 | DOI:10.1007/s10571-021-01143-x (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

40 Years of Cellular and Molecular Neurobiology
Cell Mol Neurobiol. 2021 Sep 2:1. doi: 10.1007/s10571-021-01142-y. Online ahead of print.NO ABSTRACTPMID:34476660 | PMC:PMC8412391 | DOI:10.1007/s10571-021-01142-y (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: David O Carpenter Source Type: research

Correction to: Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Sep 3. doi: 10.1007/s10571-021-01143-x. Online ahead of print.NO ABSTRACTPMID:34478003 | DOI:10.1007/s10571-021-01143-x (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

40 Years of Cellular and Molecular Neurobiology
Cell Mol Neurobiol. 2021 Sep 2:1. doi: 10.1007/s10571-021-01142-y. Online ahead of print.NO ABSTRACTPMID:34476660 | PMC:PMC8412391 | DOI:10.1007/s10571-021-01142-y (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: David O Carpenter Source Type: research

Correction to: Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Sep 3. doi: 10.1007/s10571-021-01143-x. Online ahead of print.NO ABSTRACTPMID:34478003 | DOI:10.1007/s10571-021-01143-x (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

40 Years of Cellular and Molecular Neurobiology
Cell Mol Neurobiol. 2021 Sep 2:1. doi: 10.1007/s10571-021-01142-y. Online ahead of print.NO ABSTRACTPMID:34476660 | PMC:PMC8412391 | DOI:10.1007/s10571-021-01142-y (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: David O Carpenter Source Type: research

Correction to: Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Sep 3. doi: 10.1007/s10571-021-01143-x. Online ahead of print.NO ABSTRACTPMID:34478003 | DOI:10.1007/s10571-021-01143-x (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 3, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia
Cell Mol Neurobiol. 2021 Aug 30. doi: 10.1007/s10571-021-01145-9. Online ahead of print.ABSTRACTMicroglial activation is considered as the critical pathogenic event in diverse central nervous system disorders including cerebral ischemia. Proinflammatory responses of activated microglia have been well reported in the ischemic brain and neuroinflammatory responses of activated microglia have been believed to be the potential therapeutic strategy. However, despite having proinflammatory roles, microglia can have significant anti-inflammatory roles and they are associated with the production of growth factors which are respons...
Source: Cellular and Molecular Neurobiology - August 30, 2021 Category: Cytology Authors: Bhakta Prasad Gaire Source Type: research

Deep Succinylproteomics of Brain Tissues from Intracerebral Hemorrhage with Inhibition of Toll-Like Receptor 4 Signaling
In conclusion, we revealed that several TLR4 signaling pathways affect the succinylation processes and pathways in mouse ICH brains, providing new insights on the ICH pathophysiological processes. Data are available via ProteomeXchange with identifier PXD025622.PMID:34460038 | DOI:10.1007/s10571-021-01144-w (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 30, 2021 Category: Cytology Authors: Yan-Jing Liang Yuan-Rui Yang Chuan-Yuan Tao Su-Hao Yang Xin-Xiao Zhang Jing Yuan Yuan-Hong Deng Zhan-Qiong Zhong Shu-Guang Yu Xiao-Yi Xiong Source Type: research

The Role of AMPARs Composition and Trafficking in Synaptic Plasticity and Diseases
Cell Mol Neurobiol. 2021 Aug 26. doi: 10.1007/s10571-021-01141-z. Online ahead of print.ABSTRACTAMPA receptors are tetrameric ionic glutamate receptors, which mediate 90% fast excitatory synaptic transmission induced by excitatory glutamate in the mammalian central nervous system through the activation or inactivation of ion channels. The alternation of synaptic AMPA receptor number and subtype is thought to be one of the primary mechanisms that involve in synaptic plasticity regulation and affect the functions in learning, memory, and cognition. The increasing of surface AMPARs enhances synaptic strength during long-term ...
Source: Cellular and Molecular Neurobiology - August 26, 2021 Category: Cytology Authors: Qing-Lin Wu Yan Gao Jun-Tong Li Wen-Yu Ma Nai-Hong Chen Source Type: research

A Risk Signature Consisting of Eight m < sup > 6 < /sup > A Methylation Regulators Predicts the Prognosis of Glioma
This study aims to identify glioma subtypes by clustering analysis of patients using the multi-omics data of N6-methyladenosine (m6A) methylation regulators and to construct a risk signature for investigating the role of m6A methylation regulators in the prognosis of glioma. Multi-omics data of glioma and normal control tissues were obtained through The Cancer Genome Atlas (TCGA) database. The clustering analysis of multi-omics data of patients was conducted using the R package iClusterPlus software. The risk model was constructed by univariate and multivariate Cox analysis, and the glioma expression data and related clini...
Source: Cellular and Molecular Neurobiology - August 25, 2021 Category: Cytology Authors: Sizhong Guan Ye He Yanna Su Liping Zhou Source Type: research

A Risk Signature Consisting of Eight m < sup > 6 < /sup > A Methylation Regulators Predicts the Prognosis of Glioma
This study aims to identify glioma subtypes by clustering analysis of patients using the multi-omics data of N6-methyladenosine (m6A) methylation regulators and to construct a risk signature for investigating the role of m6A methylation regulators in the prognosis of glioma. Multi-omics data of glioma and normal control tissues were obtained through The Cancer Genome Atlas (TCGA) database. The clustering analysis of multi-omics data of patients was conducted using the R package iClusterPlus software. The risk model was constructed by univariate and multivariate Cox analysis, and the glioma expression data and related clini...
Source: Cellular and Molecular Neurobiology - August 25, 2021 Category: Cytology Authors: Sizhong Guan Ye He Yanna Su Liping Zhou Source Type: research

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.PMID:34415465 | DOI:10.1007/s10571-021-01131-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 20, 2021 Category: Cytology Authors: Tony Heurtaux Melanie Kirchmeyer Eric Koncina Paul Felten Lorraine Richart Oihane Uriarte Huarte Herve Schohn Michel Mittelbronn Source Type: research

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.PMID:34415465 | DOI:10.1007/s10571-021-01131-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 20, 2021 Category: Cytology Authors: Tony Heurtaux Melanie Kirchmeyer Eric Koncina Paul Felten Lorraine Richart Oihane Uriarte Huarte Herve Schohn Michel Mittelbronn Source Type: research

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.PMID:34415465 | DOI:10.1007/s10571-021-01131-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 20, 2021 Category: Cytology Authors: Tony Heurtaux Melanie Kirchmeyer Eric Koncina Paul Felten Lorraine Richart Oihane Uriarte Huarte Herve Schohn Michel Mittelbronn Source Type: research

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.PMID:34415465 | DOI:10.1007/s10571-021-01131-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 20, 2021 Category: Cytology Authors: Tony Heurtaux Melanie Kirchmeyer Eric Koncina Paul Felten Lorraine Richart Oihane Uriarte Huarte Herve Schohn Michel Mittelbronn Source Type: research

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.PMID:34415465 | DOI:10.1007/s10571-021-01131-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 20, 2021 Category: Cytology Authors: Tony Heurtaux Melanie Kirchmeyer Eric Koncina Paul Felten Lorraine Richart Oihane Uriarte Huarte Herve Schohn Michel Mittelbronn Source Type: research

The Histopathology of Severe Graded Compression in Lower Thoracic Spinal Cord Segment of Rat, Evaluated at Late Post-injury Phase
Cell Mol Neurobiol. 2021 Aug 19. doi: 10.1007/s10571-021-01139-7. Online ahead of print.ABSTRACTSpontaneous recovery of lost motor functions is relative fast in rodent models after inducing a very mild/moderate spinal cord injury (SCI), and this may complicate a reliable evaluation of the effectiveness of potential therapy. Therefore, a severe graded (30 g, 40 g and 50 g) weight-compression SCI at the Th9 spinal segment, involving an acute mechanical impact followed by 15 min of persistent compression, was studied in adult female Wistar rats. Functional parameters, such as spontaneous recovery of motor hind limb and bladde...
Source: Cellular and Molecular Neurobiology - August 19, 2021 Category: Cytology Authors: Fedorova Jana Kellerova Erika Bimbova Katarina Pavel Jaroslav Source Type: research

The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.PMID:34383231 | DOI:10.1007/s10571-021-01133-z (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 12, 2021 Category: Cytology Authors: Zhipeng Qi Jiashuo Li Minghui Li Xianchao Du Lei Zhang Shuang Wang Bin Xu Wei Liu Zhaofa Xu Yu Deng Source Type: research

The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.PMID:34383231 | DOI:10.1007/s10571-021-01133-z (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 12, 2021 Category: Cytology Authors: Zhipeng Qi Jiashuo Li Minghui Li Xianchao Du Lei Zhang Shuang Wang Bin Xu Wei Liu Zhaofa Xu Yu Deng Source Type: research

The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.PMID:34383231 | DOI:10.1007/s10571-021-01133-z (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 12, 2021 Category: Cytology Authors: Zhipeng Qi Jiashuo Li Minghui Li Xianchao Du Lei Zhang Shuang Wang Bin Xu Wei Liu Zhaofa Xu Yu Deng Source Type: research

The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.PMID:34383231 | DOI:10.1007/s10571-021-01133-z (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 12, 2021 Category: Cytology Authors: Zhipeng Qi Jiashuo Li Minghui Li Xianchao Du Lei Zhang Shuang Wang Bin Xu Wei Liu Zhaofa Xu Yu Deng Source Type: research

The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.PMID:34383231 | DOI:10.1007/s10571-021-01133-z (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 12, 2021 Category: Cytology Authors: Zhipeng Qi Jiashuo Li Minghui Li Xianchao Du Lei Zhang Shuang Wang Bin Xu Wei Liu Zhaofa Xu Yu Deng Source Type: research

The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.PMID:34383231 | DOI:10.1007/s10571-021-01133-z (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 12, 2021 Category: Cytology Authors: Zhipeng Qi Jiashuo Li Minghui Li Xianchao Du Lei Zhang Shuang Wang Bin Xu Wei Liu Zhaofa Xu Yu Deng Source Type: research

Elastin-Derived Peptides in the Central Nervous System: Friend or Foe
Cell Mol Neurobiol. 2021 Aug 10. doi: 10.1007/s10571-021-01140-0. Online ahead of print.ABSTRACTElastin is one of the main structural matrix proteins of the arteries, lung, cartilage, elastic ligaments, brain vessels, and skin. These elastin fibers display incredible resilience and structural stability with long half-life. However, during some physiological and pathophysiological conditions, elastin is prone to proteolytic degradation and, due to the extremely low turnover rate, its degradation is practically an irreversible and irreparable phenomenon. As a result of elastin degradation, new peptides called elastin-derived...
Source: Cellular and Molecular Neurobiology - August 10, 2021 Category: Cytology Authors: Konrad A Szychowski Bartosz Sk óra Anna K W ójtowicz Source Type: research

Elastin-Derived Peptides in the Central Nervous System: Friend or Foe
Cell Mol Neurobiol. 2021 Aug 10. doi: 10.1007/s10571-021-01140-0. Online ahead of print.ABSTRACTElastin is one of the main structural matrix proteins of the arteries, lung, cartilage, elastic ligaments, brain vessels, and skin. These elastin fibers display incredible resilience and structural stability with long half-life. However, during some physiological and pathophysiological conditions, elastin is prone to proteolytic degradation and, due to the extremely low turnover rate, its degradation is practically an irreversible and irreparable phenomenon. As a result of elastin degradation, new peptides called elastin-derived...
Source: Cellular and Molecular Neurobiology - August 10, 2021 Category: Cytology Authors: Konrad A Szychowski Bartosz Sk óra Anna K W ójtowicz Source Type: research

Elastin-Derived Peptides in the Central Nervous System: Friend or Foe
Cell Mol Neurobiol. 2021 Aug 10. doi: 10.1007/s10571-021-01140-0. Online ahead of print.ABSTRACTElastin is one of the main structural matrix proteins of the arteries, lung, cartilage, elastic ligaments, brain vessels, and skin. These elastin fibers display incredible resilience and structural stability with long half-life. However, during some physiological and pathophysiological conditions, elastin is prone to proteolytic degradation and, due to the extremely low turnover rate, its degradation is practically an irreversible and irreparable phenomenon. As a result of elastin degradation, new peptides called elastin-derived...
Source: Cellular and Molecular Neurobiology - August 10, 2021 Category: Cytology Authors: Konrad A Szychowski Bartosz Sk óra Anna K W ójtowicz Source Type: research

Lithium as a Neuroprotective Agent for Bipolar Disorder: An Overview
Cell Mol Neurobiol. 2021 Aug 6. doi: 10.1007/s10571-021-01129-9. Online ahead of print.ABSTRACTLithium (Li+) is a first option treatment for adult acute episodes of Bipolar Disorder (BD) and for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as maintenance treatment. Numerous studies have shown morphological abnormalities in the brains of BD patients, suggesting that this highly heritable disorder may exhibit progressive and deleterious changes in brain structure. Since treatment with Li+ ameliorates these abnormalities, it has been postulated that Li+ is a neuroprotective agent in the ...
Source: Cellular and Molecular Neurobiology - August 6, 2021 Category: Cytology Authors: Enrique L M Ochoa Source Type: research

Lithium as a Neuroprotective Agent for Bipolar Disorder: An Overview
Cell Mol Neurobiol. 2021 Aug 6. doi: 10.1007/s10571-021-01129-9. Online ahead of print.ABSTRACTLithium (Li+) is a first option treatment for adult acute episodes of Bipolar Disorder (BD) and for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as maintenance treatment. Numerous studies have shown morphological abnormalities in the brains of BD patients, suggesting that this highly heritable disorder may exhibit progressive and deleterious changes in brain structure. Since treatment with Li+ ameliorates these abnormalities, it has been postulated that Li+ is a neuroprotective agent in the ...
Source: Cellular and Molecular Neurobiology - August 6, 2021 Category: Cytology Authors: Enrique L M Ochoa Source Type: research

Lithium as a Neuroprotective Agent for Bipolar Disorder: An Overview
Cell Mol Neurobiol. 2021 Aug 6. doi: 10.1007/s10571-021-01129-9. Online ahead of print.ABSTRACTLithium (Li+) is a first option treatment for adult acute episodes of Bipolar Disorder (BD) and for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as maintenance treatment. Numerous studies have shown morphological abnormalities in the brains of BD patients, suggesting that this highly heritable disorder may exhibit progressive and deleterious changes in brain structure. Since treatment with Li+ ameliorates these abnormalities, it has been postulated that Li+ is a neuroprotective agent in the ...
Source: Cellular and Molecular Neurobiology - August 6, 2021 Category: Cytology Authors: Enrique L M Ochoa Source Type: research

Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke
Cell Mol Neurobiol. 2021 Aug 5. doi: 10.1007/s10571-021-01138-8. Online ahead of print.ABSTRACTNeuroprotection in acute stroke has not been successfully translated from animals to humans. Animal research on promising agents continues largely in rats and mice which are commonly available to researchers. However, controversies continue on the most suitable species to model the human situation. Generally, putative agents seem less effective in mice as compared with rats. We hypothesized that this may be due to inter-species differences in stroke response and that this might be manifest at a genetic level. Here we used whole-g...
Source: Cellular and Molecular Neurobiology - August 5, 2021 Category: Cytology Authors: Qiu Jing Wu Xiujun Sun Lucy Teves Diana Mayor Michael Tymianski Source Type: research

Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke
Cell Mol Neurobiol. 2021 Aug 5. doi: 10.1007/s10571-021-01138-8. Online ahead of print.ABSTRACTNeuroprotection in acute stroke has not been successfully translated from animals to humans. Animal research on promising agents continues largely in rats and mice which are commonly available to researchers. However, controversies continue on the most suitable species to model the human situation. Generally, putative agents seem less effective in mice as compared with rats. We hypothesized that this may be due to inter-species differences in stroke response and that this might be manifest at a genetic level. Here we used whole-g...
Source: Cellular and Molecular Neurobiology - August 5, 2021 Category: Cytology Authors: Qiu Jing Wu Xiujun Sun Lucy Teves Diana Mayor Michael Tymianski Source Type: research

Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Aug 3. doi: 10.1007/s10571-021-01134-y. Online ahead of print.ABSTRACTPrevention of the nuclear translocation of ANXA1 with Tat-NTS was recently reported to alleviate neuronal injury and protect against cerebral stroke. However, the role that Tat-NTS plays in the occurrence and development of gliomas still needs to be elucidated. Therefore, human glioblastoma (GB) cells were treated with various concentrations of Tat-NTS for 24 h, and cell proliferation, migration and invasion were assessed with CCK-8 and Transwell assays. The nuclear translocation of ANXA1 was evaluated by subcellular extraction a...
Source: Cellular and Molecular Neurobiology - August 4, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease
In this study, we challenged normal and HD cells with a low-level acute ER stress and examined the molecular and cellular responses after stress removal. Using both striatal cell lines and primary neurons, we first showed the temporal activation of p-eIF2α-ATF4-GADD34 pathway in response to the acute ER stress and during recovery between normal and HD cells. HD cells were more vulnerable to cell death during stress recovery and were associated with increased number of apoptotic/necrotic cells and decreased cell proliferation. This is also supported by the Gene Ontology analysis from the RNA-seq data which indicated t...
Source: Cellular and Molecular Neurobiology - August 4, 2021 Category: Cytology Authors: Hongyuan Xu Johanna Bensalel Enrico Capobianco Michael L Lu Jianning Wei Source Type: research