Protective Effect of Hydrogen Sulfide on Cerebral Ischemia-Reperfusion Injury
Cell Mol Neurobiol. 2022 Jan 23. doi: 10.1007/s10571-021-01166-4. Online ahead of print.ABSTRACTThe brain is the most sensitive organ to hypoxia in the human body. Hypoxia in the brain will lead to damage to local brain tissue. When the blood supply of ischemic brain tissue is restored, the damage will worsen, that is, cerebral ischemia-reperfusion injury. Hydrogen sulfide (H2S) is a gaseous signal molecule and a novel endogenous neuroregulator. Indeed, different concentrations of H2S have different effects on neurons. Low concentration of H2S can play an important protective role in cerebral ischemia-reperfusion injury by...
Source: Cellular and Molecular Neurobiology - January 23, 2022 Category: Cytology Authors: Gang Deng Masood Muqadas Salah Adlat Haiyun Zheng Ge Li Ping Zhu M I Nasser Source Type: research

Glial Cells Response in Stroke
Cell Mol Neurobiol. 2022 Jan 23. doi: 10.1007/s10571-021-01183-3. Online ahead of print.ABSTRACTAs the second-leading cause of death, stroke faces several challenges in terms of treatment because of the limited therapeutic interventions available. Previous studies primarily focused on metabolic and blood flow properties as a target for treating stroke, including recombinant tissue plasminogen activator and mechanical thrombectomy, which are the only USFDA approved therapies. These interventions have the limitation of a narrow therapeutic time window, the possibility of hemorrhagic complications, and the expertise required ...
Source: Cellular and Molecular Neurobiology - January 23, 2022 Category: Cytology Authors: Poonam Jadhav Mayuri Karande Abhishek Sarkar Shubhrakanta Sahu Deepaneeta Sarmah Aishika Datta Antra Chaudhary Kiran Kalia Arvind Sharma Xin Wang Pallab Bhattacharya Source Type: research

Bi-Directional Relationship Between Autophagy and Inflammasomes in Neurodegenerative Disorders
Cell Mol Neurobiol. 2022 Jan 23. doi: 10.1007/s10571-021-01184-2. Online ahead of print.ABSTRACTThe innate immune system, as the first line of cellular defense, triggers a protective response called inflammation when encountered with invading pathogens. Inflammasome is a multi-protein cytosolic signaling complex that induces inflammation and is critical for inflammation-induced pyroptotic cell death. Inflammasome activation has been found associated with neurodegenerative disorders (NDs), inflammatory diseases, and cancer. Autophagy is a crucial intracellular quality control and homeostasis process which removes the dysfun...
Source: Cellular and Molecular Neurobiology - January 23, 2022 Category: Cytology Authors: Chinmaya Panda Rajani Kanta Mahapatra Source Type: research

Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival
In this study, we investigate the role of endogenous Il1b in the acute phase of the PILO model. Our aim is twofold. First, we want to determine whether it is feasible to silence Il1b in the central nervous system using a non-invasive procedure. Second, we aim to investigate the effect of silencing endogenous Il1b and its antagonist, Il1rn.We used RNA interference applied non-invasively to knockdown Il1b and its endogenous antagonist Il1rn. We found that knocking down Il1b prior to pilocarpine injection increased the mortality rate of treated animals. Furthermore, we observed that, when exposing the animals to more Il1b by ...
Source: Cellular and Molecular Neurobiology - January 21, 2022 Category: Cytology Authors: V D B Pascoal R B Marchesini M C P Athi é A H B Matos F F Conte T C Pereira R Secolin R Gilioli J M Malheiros R S Polli A Tann ús L Covolan L B Pascoal A S Vieira E A Cavalheiro F Cendes I Lopes-Cendes Source Type: research

Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival
In this study, we investigate the role of endogenous Il1b in the acute phase of the PILO model. Our aim is twofold. First, we want to determine whether it is feasible to silence Il1b in the central nervous system using a non-invasive procedure. Second, we aim to investigate the effect of silencing endogenous Il1b and its antagonist, Il1rn.We used RNA interference applied non-invasively to knockdown Il1b and its endogenous antagonist Il1rn. We found that knocking down Il1b prior to pilocarpine injection increased the mortality rate of treated animals. Furthermore, we observed that, when exposing the animals to more Il1b by ...
Source: Cellular and Molecular Neurobiology - January 21, 2022 Category: Cytology Authors: V D B Pascoal R B Marchesini M C P Athi é A H B Matos F F Conte T C Pereira R Secolin R Gilioli J M Malheiros R S Polli A Tann ús L Covolan L B Pascoal A S Vieira E A Cavalheiro F Cendes I Lopes-Cendes Source Type: research

Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival
In this study, we investigate the role of endogenous Il1b in the acute phase of the PILO model. Our aim is twofold. First, we want to determine whether it is feasible to silence Il1b in the central nervous system using a non-invasive procedure. Second, we aim to investigate the effect of silencing endogenous Il1b and its antagonist, Il1rn.We used RNA interference applied non-invasively to knockdown Il1b and its endogenous antagonist Il1rn. We found that knocking down Il1b prior to pilocarpine injection increased the mortality rate of treated animals. Furthermore, we observed that, when exposing the animals to more Il1b by ...
Source: Cellular and Molecular Neurobiology - January 21, 2022 Category: Cytology Authors: V D B Pascoal R B Marchesini M C P Athi é A H B Matos F F Conte T C Pereira R Secolin R Gilioli J M Malheiros R S Polli A Tann ús L Covolan L B Pascoal A S Vieira E A Cavalheiro F Cendes I Lopes-Cendes Source Type: research

Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile
The objective of this study is to identify novel candidate genes related to ALS. Transcriptome-wide association study of ALS was conducted by integrating the genome-wide association study summary data (including 1234 ALS patients and 2850 controls) and pre-computed gene expression weights of different tissues. The ALS-associated genes identified by TWAS were further compared with the differentially expressed genes detected by the mRNA expression profiles of the sporadic ALS. Functional enrichment and annotation analysis of identified genes were performed by an R package and the functional mapping and annotation software. T...
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Ping Li Shiqiang Cheng Yan Wen Bolun Cheng Li Liu Xiuhua Wu Xiang Ao Zucheng Huang Congrui Liao Shaen Li Feng Zhang Zhongmin Zhang Source Type: research

The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer's Disease: An Overview and Update on New Developments
Cell Mol Neurobiol. 2022 Jan 17. doi: 10.1007/s10571-022-01191-x. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Several findings suggest that correcting the dysregulated signaling pathways may offer a potential therapeutic approach in this disease. Extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase family, plays a major role in regulation of cell proliferation, autophagy process, and protein synthesis. The available literature suggests dysregulated ERK1/2 in AD patients with potential implications in the mult...
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Mohammad Rafi Khezri Keyvan Yousefi Ayda Esmaeili Morteza Ghasemnejad-Berenji Source Type: research

Correction to: Comparative Analysis of Behavioral Reactions and Morphological Changes in the Rat Brain After Exposure to Ionizing Radiation with Different Physical Characteristics
Cell Mol Neurobiol. 2022 Jan 17. doi: 10.1007/s10571-022-01194-8. Online ahead of print.NO ABSTRACTPMID:35038058 | DOI:10.1007/s10571-022-01194-8 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Yu S Severyukhin M Lalkovi čová D M Utina K N Lyakhova I A Kolesnikova M E Ermolaeva A G Molokanov V N Gaevsky D A Komarov E A Krasavin Source Type: research

Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile
The objective of this study is to identify novel candidate genes related to ALS. Transcriptome-wide association study of ALS was conducted by integrating the genome-wide association study summary data (including 1234 ALS patients and 2850 controls) and pre-computed gene expression weights of different tissues. The ALS-associated genes identified by TWAS were further compared with the differentially expressed genes detected by the mRNA expression profiles of the sporadic ALS. Functional enrichment and annotation analysis of identified genes were performed by an R package and the functional mapping and annotation software. T...
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Ping Li Shiqiang Cheng Yan Wen Bolun Cheng Li Liu Xiuhua Wu Xiang Ao Zucheng Huang Congrui Liao Shaen Li Feng Zhang Zhongmin Zhang Source Type: research

The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer's Disease: An Overview and Update on New Developments
Cell Mol Neurobiol. 2022 Jan 17. doi: 10.1007/s10571-022-01191-x. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Several findings suggest that correcting the dysregulated signaling pathways may offer a potential therapeutic approach in this disease. Extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase family, plays a major role in regulation of cell proliferation, autophagy process, and protein synthesis. The available literature suggests dysregulated ERK1/2 in AD patients with potential implications in the mult...
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Mohammad Rafi Khezri Keyvan Yousefi Ayda Esmaeili Morteza Ghasemnejad-Berenji Source Type: research

Correction to: Comparative Analysis of Behavioral Reactions and Morphological Changes in the Rat Brain After Exposure to Ionizing Radiation with Different Physical Characteristics
Cell Mol Neurobiol. 2022 Jan 17. doi: 10.1007/s10571-022-01194-8. Online ahead of print.NO ABSTRACTPMID:35038058 | DOI:10.1007/s10571-022-01194-8 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Yu S Severyukhin M Lalkovi čová D M Utina K N Lyakhova I A Kolesnikova M E Ermolaeva A G Molokanov V N Gaevsky D A Komarov E A Krasavin Source Type: research

Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile
The objective of this study is to identify novel candidate genes related to ALS. Transcriptome-wide association study of ALS was conducted by integrating the genome-wide association study summary data (including 1234 ALS patients and 2850 controls) and pre-computed gene expression weights of different tissues. The ALS-associated genes identified by TWAS were further compared with the differentially expressed genes detected by the mRNA expression profiles of the sporadic ALS. Functional enrichment and annotation analysis of identified genes were performed by an R package and the functional mapping and annotation software. T...
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Ping Li Shiqiang Cheng Yan Wen Bolun Cheng Li Liu Xiuhua Wu Xiang Ao Zucheng Huang Congrui Liao Shaen Li Feng Zhang Zhongmin Zhang Source Type: research

The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer's Disease: An Overview and Update on New Developments
Cell Mol Neurobiol. 2022 Jan 17. doi: 10.1007/s10571-022-01191-x. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Several findings suggest that correcting the dysregulated signaling pathways may offer a potential therapeutic approach in this disease. Extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase family, plays a major role in regulation of cell proliferation, autophagy process, and protein synthesis. The available literature suggests dysregulated ERK1/2 in AD patients with potential implications in the mult...
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Mohammad Rafi Khezri Keyvan Yousefi Ayda Esmaeili Morteza Ghasemnejad-Berenji Source Type: research

Correction to: Comparative Analysis of Behavioral Reactions and Morphological Changes in the Rat Brain After Exposure to Ionizing Radiation with Different Physical Characteristics
Cell Mol Neurobiol. 2022 Jan 17. doi: 10.1007/s10571-022-01194-8. Online ahead of print.NO ABSTRACTPMID:35038058 | DOI:10.1007/s10571-022-01194-8 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - January 17, 2022 Category: Cytology Authors: Yu S Severyukhin M Lalkovi čová D M Utina K N Lyakhova I A Kolesnikova M E Ermolaeva A G Molokanov V N Gaevsky D A Komarov E A Krasavin Source Type: research

Effect of Thiazolidin-4-one Against Lipopolysaccharide-Induced Oxidative Damage, and Alterations in Adenine Nucleotide Hydrolysis and Acetylcholinesterase Activity in Cultured Astrocytes
Cell Mol Neurobiol. 2022 Jan 15. doi: 10.1007/s10571-021-01177-1. Online ahead of print.ABSTRACTAstrocytes play multiple important roles in brain physiology. However, depending on the stimuli, astrocytes may exacerbate inflammatory reactions, contributing to the development and progression of neurological diseases. Therefore, therapies targeting astrocytes represent a promising area for the development of new brain drugs. Thiazolidinones are heterocyclic compounds that have a sulfur and nitrogen atom and a carbonyl group in the ring and represent a class of compounds of great scientific interest due to their pharmacologica...
Source: Cellular and Molecular Neurobiology - January 15, 2022 Category: Cytology Authors: Fernando Lopez Alvez Nat ália Pontes Bona Nathalia Stark Pedra Daniel Schuch da Silva Wilson Jo ão Cunico Francieli Moro Stefanello Cinthia Melazzo de Andrade Mayara Sandrielly Pereira Soares Roselia Maria Spanevello Source Type: research

Roles of Phosphorylation of N-Methyl-D-Aspartate Receptor in Chronic Pain
Cell Mol Neurobiol. 2022 Jan 15. doi: 10.1007/s10571-022-01188-6. Online ahead of print.ABSTRACTPhosphorylation of N-methyl-D-aspartate receptor (NMDAR) is widely regarded as a vital modification of synaptic function. Various protein kinases are responsible for direct phosphorylation of NMDAR, such as cyclic adenosine monophosphate-dependent protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, Src family protein tyrosine kinases, cyclin-dependent kinase 5, and casein kinase II. The detailed function of these kinases on distinct subunits of NMDAR has been reported previously and contributes to ph...
Source: Cellular and Molecular Neurobiology - January 15, 2022 Category: Cytology Authors: Liangyu Pan Tiansheng Li Rui Wang Weiheng Deng Huangsheng Pu Meichun Deng Source Type: research

Effect of Thiazolidin-4-one Against Lipopolysaccharide-Induced Oxidative Damage, and Alterations in Adenine Nucleotide Hydrolysis and Acetylcholinesterase Activity in Cultured Astrocytes
Cell Mol Neurobiol. 2022 Jan 15. doi: 10.1007/s10571-021-01177-1. Online ahead of print.ABSTRACTAstrocytes play multiple important roles in brain physiology. However, depending on the stimuli, astrocytes may exacerbate inflammatory reactions, contributing to the development and progression of neurological diseases. Therefore, therapies targeting astrocytes represent a promising area for the development of new brain drugs. Thiazolidinones are heterocyclic compounds that have a sulfur and nitrogen atom and a carbonyl group in the ring and represent a class of compounds of great scientific interest due to their pharmacologica...
Source: Cellular and Molecular Neurobiology - January 15, 2022 Category: Cytology Authors: Fernando Lopez Alvez Nat ália Pontes Bona Nathalia Stark Pedra Daniel Schuch da Silva Wilson Jo ão Cunico Francieli Moro Stefanello Cinthia Melazzo de Andrade Mayara Sandrielly Pereira Soares Roselia Maria Spanevello Source Type: research

Roles of Phosphorylation of N-Methyl-D-Aspartate Receptor in Chronic Pain
Cell Mol Neurobiol. 2022 Jan 15. doi: 10.1007/s10571-022-01188-6. Online ahead of print.ABSTRACTPhosphorylation of N-methyl-D-aspartate receptor (NMDAR) is widely regarded as a vital modification of synaptic function. Various protein kinases are responsible for direct phosphorylation of NMDAR, such as cyclic adenosine monophosphate-dependent protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, Src family protein tyrosine kinases, cyclin-dependent kinase 5, and casein kinase II. The detailed function of these kinases on distinct subunits of NMDAR has been reported previously and contributes to ph...
Source: Cellular and Molecular Neurobiology - January 15, 2022 Category: Cytology Authors: Liangyu Pan Tiansheng Li Rui Wang Weiheng Deng Huangsheng Pu Meichun Deng Source Type: research

Effect of Thiazolidin-4-one Against Lipopolysaccharide-Induced Oxidative Damage, and Alterations in Adenine Nucleotide Hydrolysis and Acetylcholinesterase Activity in Cultured Astrocytes
Cell Mol Neurobiol. 2022 Jan 15. doi: 10.1007/s10571-021-01177-1. Online ahead of print.ABSTRACTAstrocytes play multiple important roles in brain physiology. However, depending on the stimuli, astrocytes may exacerbate inflammatory reactions, contributing to the development and progression of neurological diseases. Therefore, therapies targeting astrocytes represent a promising area for the development of new brain drugs. Thiazolidinones are heterocyclic compounds that have a sulfur and nitrogen atom and a carbonyl group in the ring and represent a class of compounds of great scientific interest due to their pharmacologica...
Source: Cellular and Molecular Neurobiology - January 15, 2022 Category: Cytology Authors: Fernando Lopez Alvez Nat ália Pontes Bona Nathalia Stark Pedra Daniel Schuch da Silva Wilson Jo ão Cunico Francieli Moro Stefanello Cinthia Melazzo de Andrade Mayara Sandrielly Pereira Soares Roselia Maria Spanevello Source Type: research

Roles of Phosphorylation of N-Methyl-D-Aspartate Receptor in Chronic Pain
Cell Mol Neurobiol. 2022 Jan 15. doi: 10.1007/s10571-022-01188-6. Online ahead of print.ABSTRACTPhosphorylation of N-methyl-D-aspartate receptor (NMDAR) is widely regarded as a vital modification of synaptic function. Various protein kinases are responsible for direct phosphorylation of NMDAR, such as cyclic adenosine monophosphate-dependent protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, Src family protein tyrosine kinases, cyclin-dependent kinase 5, and casein kinase II. The detailed function of these kinases on distinct subunits of NMDAR has been reported previously and contributes to ph...
Source: Cellular and Molecular Neurobiology - January 15, 2022 Category: Cytology Authors: Liangyu Pan Tiansheng Li Rui Wang Weiheng Deng Huangsheng Pu Meichun Deng Source Type: research

COVID-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation
In this study, we have first described the advantages and disadvantages of neuroinflammation in the pathological evolution after IS and summarized the characteristics of neuroinflammation in COVID-19-related stroke. Then, we have discussed the potential benefit of MSC-EVs in the regulation of inflammatory responses after COVID-19-induced ischemic events.PMID:35025001 | PMC:PMC8755896 | DOI:10.1007/s10571-021-01169-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - January 13, 2022 Category: Cytology Authors: Leyla Norouzi-Barough Amir Asgari Khosroshahi Ali Gorji Fariba Zafari Mohammad Shahverdi Shahraki Sadegh Shirian Source Type: research

COVID-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation
In this study, we have first described the advantages and disadvantages of neuroinflammation in the pathological evolution after IS and summarized the characteristics of neuroinflammation in COVID-19-related stroke. Then, we have discussed the potential benefit of MSC-EVs in the regulation of inflammatory responses after COVID-19-induced ischemic events.PMID:35025001 | PMC:PMC8755896 | DOI:10.1007/s10571-021-01169-1 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - January 13, 2022 Category: Cytology Authors: Leyla Norouzi-Barough Amir Asgari Khosroshahi Ali Gorji Fariba Zafari Mohammad Shahverdi Shahraki Sadegh Shirian Source Type: research

The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01176-2. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of morbidity and mortality worldwide, and rapidly increasing annually with no more effective therapeutic measures. Thus, the novel diagnostic and prognostic biomarkers are urgent to be identified for prevention and therapy of ischemic stroke. Recently, long noncoding RNAs (lncRNAs), a major family of noncoding RNAs with more than 200 nucleotides, have been considered as new targets for modulating pathological process of ischemic stroke. In this review, we summarized that the l...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Yanfang Zhao Yingying Liu Qili Zhang Hongliang Liu Jianing Xu Source Type: research

Aminochrome Induces Neuroinflammation and Dopaminergic Neuronal Loss: A New Preclinical Model to Find Anti-inflammatory and Neuroprotective Drugs for Parkinson's Disease
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01173-5. Online ahead of print.ABSTRACTStudies have suggested aminochrome as an endogenous neurotoxin responsible for the dopaminergic neuron degeneration in Parkinson's disease (PD). However, neuroinflammation, an important alteration in PD pathogenesis, has been strictly induced in vitro by aminochrome. The aim of this study was to characterize the neuroinflammation induced in vivo by aminochrome. Wistar rats (male, 250-270 g) received a unilateral single dose by stereotaxic injection of saline into three sites in the striatum in the negative control group, or 32 nm...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Fillipe Mendes De Ara újo Annyta Fernandes Frota L ívia Bacelar de Jesus Ticiane Caribe Macedo Lorena Cuenca-Bermejo Consuelo Sanchez-Rodrigo Kariny Maria Silva Ferreira Juciele Val éria Ribeiro de Oliveira Maria de Fatima Dias Costa Juan Segura-Aguila Source Type: research

The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01176-2. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of morbidity and mortality worldwide, and rapidly increasing annually with no more effective therapeutic measures. Thus, the novel diagnostic and prognostic biomarkers are urgent to be identified for prevention and therapy of ischemic stroke. Recently, long noncoding RNAs (lncRNAs), a major family of noncoding RNAs with more than 200 nucleotides, have been considered as new targets for modulating pathological process of ischemic stroke. In this review, we summarized that the l...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Yanfang Zhao Yingying Liu Qili Zhang Hongliang Liu Jianing Xu Source Type: research

Aminochrome Induces Neuroinflammation and Dopaminergic Neuronal Loss: A New Preclinical Model to Find Anti-inflammatory and Neuroprotective Drugs for Parkinson's Disease
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01173-5. Online ahead of print.ABSTRACTStudies have suggested aminochrome as an endogenous neurotoxin responsible for the dopaminergic neuron degeneration in Parkinson's disease (PD). However, neuroinflammation, an important alteration in PD pathogenesis, has been strictly induced in vitro by aminochrome. The aim of this study was to characterize the neuroinflammation induced in vivo by aminochrome. Wistar rats (male, 250-270 g) received a unilateral single dose by stereotaxic injection of saline into three sites in the striatum in the negative control group, or 32 nm...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Fillipe Mendes De Ara újo Annyta Fernandes Frota L ívia Bacelar de Jesus Ticiane Caribe Macedo Lorena Cuenca-Bermejo Consuelo Sanchez-Rodrigo Kariny Maria Silva Ferreira Juciele Val éria Ribeiro de Oliveira Maria de Fatima Dias Costa Juan Segura-Aguila Source Type: research

The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01176-2. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of morbidity and mortality worldwide, and rapidly increasing annually with no more effective therapeutic measures. Thus, the novel diagnostic and prognostic biomarkers are urgent to be identified for prevention and therapy of ischemic stroke. Recently, long noncoding RNAs (lncRNAs), a major family of noncoding RNAs with more than 200 nucleotides, have been considered as new targets for modulating pathological process of ischemic stroke. In this review, we summarized that the l...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Yanfang Zhao Yingying Liu Qili Zhang Hongliang Liu Jianing Xu Source Type: research

Aminochrome Induces Neuroinflammation and Dopaminergic Neuronal Loss: A New Preclinical Model to Find Anti-inflammatory and Neuroprotective Drugs for Parkinson's Disease
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01173-5. Online ahead of print.ABSTRACTStudies have suggested aminochrome as an endogenous neurotoxin responsible for the dopaminergic neuron degeneration in Parkinson's disease (PD). However, neuroinflammation, an important alteration in PD pathogenesis, has been strictly induced in vitro by aminochrome. The aim of this study was to characterize the neuroinflammation induced in vivo by aminochrome. Wistar rats (male, 250-270 g) received a unilateral single dose by stereotaxic injection of saline into three sites in the striatum in the negative control group, or 32 nm...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Fillipe Mendes De Ara újo Annyta Fernandes Frota L ívia Bacelar de Jesus Ticiane Caribe Macedo Lorena Cuenca-Bermejo Consuelo Sanchez-Rodrigo Kariny Maria Silva Ferreira Juciele Val éria Ribeiro de Oliveira Maria de Fatima Dias Costa Juan Segura-Aguila Source Type: research

The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01176-2. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of morbidity and mortality worldwide, and rapidly increasing annually with no more effective therapeutic measures. Thus, the novel diagnostic and prognostic biomarkers are urgent to be identified for prevention and therapy of ischemic stroke. Recently, long noncoding RNAs (lncRNAs), a major family of noncoding RNAs with more than 200 nucleotides, have been considered as new targets for modulating pathological process of ischemic stroke. In this review, we summarized that the l...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Yanfang Zhao Yingying Liu Qili Zhang Hongliang Liu Jianing Xu Source Type: research

Aminochrome Induces Neuroinflammation and Dopaminergic Neuronal Loss: A New Preclinical Model to Find Anti-inflammatory and Neuroprotective Drugs for Parkinson's Disease
Cell Mol Neurobiol. 2022 Jan 6. doi: 10.1007/s10571-021-01173-5. Online ahead of print.ABSTRACTStudies have suggested aminochrome as an endogenous neurotoxin responsible for the dopaminergic neuron degeneration in Parkinson's disease (PD). However, neuroinflammation, an important alteration in PD pathogenesis, has been strictly induced in vitro by aminochrome. The aim of this study was to characterize the neuroinflammation induced in vivo by aminochrome. Wistar rats (male, 250-270 g) received a unilateral single dose by stereotaxic injection of saline into three sites in the striatum in the negative control group, or 32 nm...
Source: Cellular and Molecular Neurobiology - January 6, 2022 Category: Cytology Authors: Fillipe Mendes De Ara újo Annyta Fernandes Frota L ívia Bacelar de Jesus Ticiane Caribe Macedo Lorena Cuenca-Bermejo Consuelo Sanchez-Rodrigo Kariny Maria Silva Ferreira Juciele Val éria Ribeiro de Oliveira Maria de Fatima Dias Costa Juan Segura-Aguila Source Type: research

The Critical Role of Erythrolysis and Microglia/Macrophages in Clot Resolution After Intracerebral Hemorrhage: A Review of the Mechanisms and Potential Therapeutic Targets
Cell Mol Neurobiol. 2022 Jan 4. doi: 10.1007/s10571-021-01175-3. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a common cerebrovascular disorder with high morbidity and mortality. Secondary brain injury after ICH, which is initiated by multiple hemolytic products during erythrolysis, has been identified as a critical factor accounting for the poor prognosis of ICH patients. Clot resolution and hematoma clearance occur immediately after ICH via erythrolysis and erythrophagocytosis. During this process, erythrolysis after ICH results in the release of hemoglobin and products of degradation along with rapid ...
Source: Cellular and Molecular Neurobiology - January 4, 2022 Category: Cytology Authors: Yonghe Zheng Xiaoxiao Tan Shenglong Cao Source Type: research

Evidence for Menopause as a Sex-Specific Risk Factor for Glaucoma
Cell Mol Neurobiol. 2022 Jan 4. doi: 10.1007/s10571-021-01179-z. Online ahead of print.ABSTRACTGlaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive loss of visual function and retinal ganglion cells (RGC). Current epidemiological, clinical, and basic science evidence suggest that estrogen plays a role in the aging of the optic nerve. Menopause, a major biological life event affecting all women, coincides with a decrease in circulating sex hormones, such as estrogen. While 59% of the glaucomatous population are females, sex is not considered a risk factor for developing glaucom...
Source: Cellular and Molecular Neurobiology - January 4, 2022 Category: Cytology Authors: Amber Douglass Michael Dattilo Andrew J Feola Source Type: research

Comparative Analysis of Behavioral Reactions and Morphological Changes in the Rat Brain After Exposure to Ionizing Radiation with Different Physical Characteristics
Cell Mol Neurobiol. 2022 Jan 4. doi: 10.1007/s10571-021-01187-z. Online ahead of print.ABSTRACTThe aim of this research was to study behavioral reactions and morphological changes in the brain of adult female Sprague Dawley rats after exposure to 170 MeV and 70 MeV protons and gamma radiation (60Co) at a dose of 1 Gy. The analysis of the behavioral reactions in the T-maze showed that exposure to ionizing radiation with different LETs led to an increase in number of repeated entries into the arms of the maze in the spontaneous alternation test. In the Open Field test a decrease in overall motor activity in the group of irra...
Source: Cellular and Molecular Neurobiology - January 4, 2022 Category: Cytology Authors: Yu S Severyukhin M Lalkovi čová D M Utina K N Lyakhova I A Kolesnikova M E Ermolaeva A G Molokanov V N Gaevsky D A Komarov E A Krasavin Source Type: research

Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators
Cell Mol Neurobiol. 2022 Jan 3. doi: 10.1007/s10571-021-01185-1. Online ahead of print.ABSTRACTNMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing N...
Source: Cellular and Molecular Neurobiology - January 3, 2022 Category: Cytology Authors: Menghan Niu Xin Yang Yuanyuan Li Yanping Sun Long Wang Jing Ha Yinghua Xie Zibin Gao Changzheng Tian Le Wang Yongjun Sun Source Type: research

Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators
Cell Mol Neurobiol. 2022 Jan 3. doi: 10.1007/s10571-021-01185-1. Online ahead of print.ABSTRACTNMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing N...
Source: Cellular and Molecular Neurobiology - January 3, 2022 Category: Cytology Authors: Menghan Niu Xin Yang Yuanyuan Li Yanping Sun Long Wang Jing Ha Yinghua Xie Zibin Gao Changzheng Tian Le Wang Yongjun Sun Source Type: research

Correction to: Overexpression of miR-124 Protects Against Neurological Dysfunction Induced by Neonatal Hypoxic-Ischemic Brain Injury
Cell Mol Neurobiol. 2021 Dec 28. doi: 10.1007/s10571-021-01178-0. Online ahead of print.NO ABSTRACTPMID:34962600 | DOI:10.1007/s10571-021-01178-0 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 28, 2021 Category: Cytology Authors: Liulin Xiong Haoli Zhou Qiong Zhao Lulu Xue Mohammed Al-Hawwas Jingyuan He Maxiu Wu Yu Zou Mingan Yang Jing Dai Manxi He Tinghua Wang Source Type: research

Correction to: Overexpression of miR-124 Protects Against Neurological Dysfunction Induced by Neonatal Hypoxic-Ischemic Brain Injury
Cell Mol Neurobiol. 2021 Dec 28. doi: 10.1007/s10571-021-01178-0. Online ahead of print.NO ABSTRACTPMID:34962600 | DOI:10.1007/s10571-021-01178-0 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 28, 2021 Category: Cytology Authors: Liulin Xiong Haoli Zhou Qiong Zhao Lulu Xue Mohammed Al-Hawwas Jingyuan He Maxiu Wu Yu Zou Mingan Yang Jing Dai Manxi He Tinghua Wang Source Type: research

Correction to: Overexpression of miR-124 Protects Against Neurological Dysfunction Induced by Neonatal Hypoxic-Ischemic Brain Injury
Cell Mol Neurobiol. 2021 Dec 28. doi: 10.1007/s10571-021-01178-0. Online ahead of print.NO ABSTRACTPMID:34962600 | DOI:10.1007/s10571-021-01178-0 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 28, 2021 Category: Cytology Authors: Liulin Xiong Haoli Zhou Qiong Zhao Lulu Xue Mohammed Al-Hawwas Jingyuan He Maxiu Wu Yu Zou Mingan Yang Jing Dai Manxi He Tinghua Wang Source Type: research

Correction to: Overexpression of miR-124 Protects Against Neurological Dysfunction Induced by Neonatal Hypoxic-Ischemic Brain Injury
Cell Mol Neurobiol. 2021 Dec 28. doi: 10.1007/s10571-021-01178-0. Online ahead of print.NO ABSTRACTPMID:34962600 | DOI:10.1007/s10571-021-01178-0 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 28, 2021 Category: Cytology Authors: Liulin Xiong Haoli Zhou Qiong Zhao Lulu Xue Mohammed Al-Hawwas Jingyuan He Maxiu Wu Yu Zou Mingan Yang Jing Dai Manxi He Tinghua Wang Source Type: research

Correction to: Overexpression of miR-124 Protects Against Neurological Dysfunction Induced by Neonatal Hypoxic-Ischemic Brain Injury
Cell Mol Neurobiol. 2021 Dec 28. doi: 10.1007/s10571-021-01178-0. Online ahead of print.NO ABSTRACTPMID:34962600 | DOI:10.1007/s10571-021-01178-0 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 28, 2021 Category: Cytology Authors: Liulin Xiong Haoli Zhou Qiong Zhao Lulu Xue Mohammed Al-Hawwas Jingyuan He Maxiu Wu Yu Zou Mingan Yang Jing Dai Manxi He Tinghua Wang Source Type: research

Methods to Study the Myenteric Plexus of Rat Small Intestine
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01181-5. Online ahead of print.ABSTRACTThe close interaction between the enteric nervous system, microbiome, and brain in vertebrates is an emerging topic of recent studies. Different species such as rat, mouse, and human are currently being used for this purpose, among others. The transferability of protocols for tissue isolation and sample collection is not always straightforward. Thus, the present work presents a new protocol for isolation and sample collection of rat myenteric plexus cells for in vivo as well as in vitro studies. With the methods and chemicals de...
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Ines Hecking Lennart Norman Stegemann Sarah Stahlke Verena Theis Matthias Vorgerd Veronika Matschke Carsten Theiss Source Type: research

Correction to: Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01182-4. Online ahead of print.NO ABSTRACTPMID:34932175 | DOI:10.1007/s10571-021-01182-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Martin Gabay Abraham Weizman Nidal Zeineh Meygal Kahana Fadi Obeid Nahum Allon Moshe Gavish Source Type: research

Methods to Study the Myenteric Plexus of Rat Small Intestine
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01181-5. Online ahead of print.ABSTRACTThe close interaction between the enteric nervous system, microbiome, and brain in vertebrates is an emerging topic of recent studies. Different species such as rat, mouse, and human are currently being used for this purpose, among others. The transferability of protocols for tissue isolation and sample collection is not always straightforward. Thus, the present work presents a new protocol for isolation and sample collection of rat myenteric plexus cells for in vivo as well as in vitro studies. With the methods and chemicals de...
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Ines Hecking Lennart Norman Stegemann Sarah Stahlke Verena Theis Matthias Vorgerd Veronika Matschke Carsten Theiss Source Type: research

Correction to: Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01182-4. Online ahead of print.NO ABSTRACTPMID:34932175 | DOI:10.1007/s10571-021-01182-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Martin Gabay Abraham Weizman Nidal Zeineh Meygal Kahana Fadi Obeid Nahum Allon Moshe Gavish Source Type: research

Methods to Study the Myenteric Plexus of Rat Small Intestine
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01181-5. Online ahead of print.ABSTRACTThe close interaction between the enteric nervous system, microbiome, and brain in vertebrates is an emerging topic of recent studies. Different species such as rat, mouse, and human are currently being used for this purpose, among others. The transferability of protocols for tissue isolation and sample collection is not always straightforward. Thus, the present work presents a new protocol for isolation and sample collection of rat myenteric plexus cells for in vivo as well as in vitro studies. With the methods and chemicals de...
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Ines Hecking Lennart Norman Stegemann Sarah Stahlke Verena Theis Matthias Vorgerd Veronika Matschke Carsten Theiss Source Type: research

Correction to: Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01182-4. Online ahead of print.NO ABSTRACTPMID:34932175 | DOI:10.1007/s10571-021-01182-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Martin Gabay Abraham Weizman Nidal Zeineh Meygal Kahana Fadi Obeid Nahum Allon Moshe Gavish Source Type: research

Methods to Study the Myenteric Plexus of Rat Small Intestine
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01181-5. Online ahead of print.ABSTRACTThe close interaction between the enteric nervous system, microbiome, and brain in vertebrates is an emerging topic of recent studies. Different species such as rat, mouse, and human are currently being used for this purpose, among others. The transferability of protocols for tissue isolation and sample collection is not always straightforward. Thus, the present work presents a new protocol for isolation and sample collection of rat myenteric plexus cells for in vivo as well as in vitro studies. With the methods and chemicals de...
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Ines Hecking Lennart Norman Stegemann Sarah Stahlke Verena Theis Matthias Vorgerd Veronika Matschke Carsten Theiss Source Type: research

Correction to: Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01182-4. Online ahead of print.NO ABSTRACTPMID:34932175 | DOI:10.1007/s10571-021-01182-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Martin Gabay Abraham Weizman Nidal Zeineh Meygal Kahana Fadi Obeid Nahum Allon Moshe Gavish Source Type: research

Methods to Study the Myenteric Plexus of Rat Small Intestine
Cell Mol Neurobiol. 2021 Dec 21. doi: 10.1007/s10571-021-01181-5. Online ahead of print.ABSTRACTThe close interaction between the enteric nervous system, microbiome, and brain in vertebrates is an emerging topic of recent studies. Different species such as rat, mouse, and human are currently being used for this purpose, among others. The transferability of protocols for tissue isolation and sample collection is not always straightforward. Thus, the present work presents a new protocol for isolation and sample collection of rat myenteric plexus cells for in vivo as well as in vitro studies. With the methods and chemicals de...
Source: Cellular and Molecular Neurobiology - December 21, 2021 Category: Cytology Authors: Ines Hecking Lennart Norman Stegemann Sarah Stahlke Verena Theis Matthias Vorgerd Veronika Matschke Carsten Theiss Source Type: research