Defining responders to therapies by a statistical modeling approach applied to randomized clinical trial data
Personalized medicine is the tailoring of treatment to the individual characteristics of patients. Once a treatment has been tested in a clinical trial and its effect overall quantified, it would be of great v... (Source: BMC Medicine)
Source: BMC Medicine - June 18, 2019 Category: Internal Medicine Authors: Francesca Bovis, Luca Carmisciano, Alessio Signori, Matteo Pardini, Joshua R. Steinerman, Thomas Li, Aaron P. Tansy and Maria Pia Sormani Tags: Research article Source Type: research

Postmarketing commitments for novel drugs and biologics approved by the US Food and Drug Administration: a cross-sectional analysis
Postmarketing commitments are clinical studies that pharmaceutical companies agree to conduct at the time of FDA approval, but which are not required by statute or regulation. As FDA increasingly adopts a life... (Source: BMC Medicine)
Source: BMC Medicine - June 17, 2019 Category: Internal Medicine Authors: Joshua D. Wallach, Anita T. Luxkaranayagam, Sanket S. Dhruva, Jennifer E. Miller and Joseph S. Ross Tags: Research article Source Type: research

Estimated nationwide impact of implementing a preemptive pharmacogenetic panel approach to guide drug prescribing in primary care in The Netherlands
Pharmacogenetics (PGx) is currently implemented in hospitals to optimize therapy with high-risk drugs. However, many drugs with dosing recommendations from the Dutch Pharmacogenetics Working Group and the Clin... (Source: BMC Medicine)
Source: BMC Medicine - June 14, 2019 Category: Internal Medicine Authors: P. C. D. Bank, J. J. Swen and H. J. Guchelaar Tags: Research article Source Type: research

Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis
The Framingham risk models and pooled cohort equations (PCE) are widely used and advocated in guidelines for predicting 10-year risk of developing coronary heart disease (CHD) and cardiovascular disease (CVD) ... (Source: BMC Medicine)
Source: BMC Medicine - June 13, 2019 Category: Internal Medicine Authors: Johanna A. Damen, Romin Pajouheshnia, Pauline Heus, Karel G. M. Moons, Johannes B. Reitsma, Rob J. P. M. Scholten, Lotty Hooft and Thomas P. A. Debray Tags: Research article Source Type: research

Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study
Multimorbidity is an emerging public health priority. Physical activity (PA) is recommended as one of the main lifestyle behaviours, yet the benefits of PA for people with multimorbidity are unclear. We assess... (Source: BMC Medicine)
Source: BMC Medicine - June 12, 2019 Category: Internal Medicine Authors: Yogini V. Chudasama, Kamlesh K. Khunti, Francesco Zaccardi, Alex V. Rowlands, Thomas Yates, Clare L. Gillies, Melanie J. Davies and Nafeesa N. Dhalwani Tags: Research article Source Type: research

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks —results from the Lassa fever pilot
Infectious disease epidemics are a constant threat, and while we can strengthen preparedness in advance, inevitably, we will sometimes be caught unaware by novel outbreaks. To address the challenge of rapidly ... (Source: BMC Medicine)
Source: BMC Medicine - June 11, 2019 Category: Internal Medicine Authors: Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke and Peter Horby Tags: Research article Source Type: research

Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma
Intratumoral immune infiltrates have manifested a robust prognostic signature in patients with hepatocellular carcinoma (HCC). We hypothesized that a novel tissue-related immune signature (TRIS) could improve ... (Source: BMC Medicine)
Source: BMC Medicine - June 5, 2019 Category: Internal Medicine Authors: Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou & hellip; Tags: Research article Source Type: research

Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit
News stories represent an important source of information. We aimed to evaluate the impact of “spin” (i.e., misrepresentation of study results) in health news stories reporting studies of pharmacologic treatme... (Source: BMC Medicine)
Source: BMC Medicine - June 4, 2019 Category: Internal Medicine Authors: Isabelle Boutron, Romana Haneef, Am élie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer and Philippe Ravaud Tags: Research article Source Type: research

Monitoring progress in reducing maternal mortality using verbal autopsy methods in vital registration systems: what can we conclude about specific causes of maternal death?
Reducing maternal mortality is a key focus of development strategies and one of the indicators used to measure progress towards achieving the Sustainable Development Goals. In the absence of medical certificat... (Source: BMC Medicine)
Source: BMC Medicine - June 3, 2019 Category: Internal Medicine Authors: Ian D. Riley, Riley H. Hazard, Rohina Joshi, Hafizur Rahman Chowdhury and Alan D. Lopez Tags: Correspondence Source Type: research

The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study
Accurate and timely diagnosis of malaria is essential for disease management and surveillance. Thin and thick blood smear microscopy and malaria rapid diagnostic tests (RDTs) are standard malaria diagnostics, ... (Source: BMC Medicine)
Source: BMC Medicine - May 31, 2019 Category: Internal Medicine Authors: Annelies Post, Berenger Kabor é, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast and Andr Tags: Research article Source Type: research

An integrated approach to processing WHO-2016 verbal autopsy data: the InterVA-5 model
Verbal autopsy is an increasingly important methodology for assigning causes to otherwise uncertified deaths, which amount to around 50% of global mortality and cause much uncertainty for health planning. The ... (Source: BMC Medicine)
Source: BMC Medicine - May 30, 2019 Category: Internal Medicine Authors: Peter Byass, Laith Hussain-Alkhateeb, Lucia D ’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler and Max Petzold Tags: Software Source Type: research

Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys
Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especi... (Source: BMC Medicine)
Source: BMC Medicine - May 24, 2019 Category: Internal Medicine Authors: Ymkje Anna de Vries, Ali Al-Hamzawi, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, Jos é Miguel Caldas-de-Almeida, Alfredo H. Cia, Giovanni De Girolamo, Rumyana V. Dinolova, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep Maria Haro Tags: Research article Source Type: research

Ethnic differences in prediabetes incidence among immigrants to Canada: a population-based cohort study
This study examined the incidence of prediabetes among immigrants to Canada of different ethnic origins and the age at which ethnic differences emerged. (Source: BMC Medicine)
Source: BMC Medicine - May 23, 2019 Category: Internal Medicine Authors: Ghazal S. Fazli, Rahim Moineddin, Arlene S. Bierman and Gillian L. Booth Tags: Research article Source Type: research

Effects of school neighborhood food environments on childhood obesity at multiple scales: a longitudinal kindergarten cohort study in the USA
This study aimed to examine this association a... (Source: BMC Medicine)
Source: BMC Medicine - May 22, 2019 Category: Internal Medicine Authors: Peng Jia, Hong Xue, Xi Cheng and Youfa Wang Tags: Research article Source Type: research

Commentary on a recent article on the effects of the ‘Daily Mile’ on physical activity, fitness and body composition: addressing key limitations
A recent pilot study by Chesham et al. in BMC Medicine established some initial effects of the Daily Mile ™ using a quasi-experimental repeated measures design, with valid and reliable outcome assessments for mode... (Source: BMC Medicine)
Source: BMC Medicine - May 22, 2019 Category: Internal Medicine Authors: Andy Daly-Smith, Jade L. Morris, Matthew Hobbs and Jim McKenna Tags: Correspondence Source Type: research

Response to Daly-Smith et al. ’s commentary on ‘The Daily Mile makes primary school children more active, less sedentary and improves their fitness and body composition: a quasi-experimental pilot study’
We thank Daly-Smith et al. for taking the time to read the results of our pilot research study, describing it as an important and welcome contribution. Nonetheless, the authors argue six points against our con... (Source: BMC Medicine)
Source: BMC Medicine - May 22, 2019 Category: Internal Medicine Authors: Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks and Colin N. Moran Tags: Correspondence Source Type: research

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria
Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown. (Source: BMC Medicine)
Source: BMC Medicine - May 21, 2019 Category: Internal Medicine Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Richard Idro, John M. Ssenkusu, Dibyadyuti Datta, James S. Hodges, Catherine Morgan and Chandy C. John Tags: Research article Source Type: research

Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts
Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Here we used healthcare records of 18 m... (Source: BMC Medicine)
Source: BMC Medicine - May 20, 2019 Category: Internal Medicine Authors: Myriam Alexander, A. Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M. Waterworth, Stuart Kendrick, Naveed Sattar and William Alazawi Tags: Research article Source Type: research

The introduction of ‘No jab, No school’ policy and the refinement of measles immunisation strategies in high-income countries
In recent years, we witnessed a resurgence of measles even in countries where, according to WHO guidelines, elimination should have already been achieved. In high-income countries, the raise of anti-vaccinatio... (Source: BMC Medicine)
Source: BMC Medicine - May 17, 2019 Category: Internal Medicine Authors: Filippo Trentini, Piero Poletti, Alessia Melegaro and Stefano Merler Tags: Research article Source Type: research

Claims of causality in health news: a randomised trial
Misleading news claims can be detrimental to public health. We aimed to improve the alignment between causal claims and evidence, without losing news interest (counter to assumptions that news is not intereste... (Source: BMC Medicine)
Source: BMC Medicine - May 16, 2019 Category: Internal Medicine Authors: Rachel C. Adams, Aim ée Challenger, Luke Bratton, Jacky Boivin, Lewis Bott, Georgina Powell, Andy Williams, Christopher D. Chambers and Petroc Sumner Tags: Research article Source Type: research

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study
Frailty index (FI) is a well-established predictor of all-cause mortality, but less is known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are al... (Source: BMC Medicine)
Source: BMC Medicine - May 15, 2019 Category: Internal Medicine Authors: Xia Li, Alexander Ploner, Ida K. Karlsson, Xingrong Liu, Patrik K. E. Magnusson, Nancy L. Pedersen, Sara H ägg and Juulia Jylhävä Tags: Research article Source Type: research

The classification of feeding and eating disorders in the ICD-11: results of a field study comparing proposed ICD-11 guidelines with existing ICD-10 guidelines
The World Health Organization (WHO) International Classification of Diseases and Related Health Problems (ICD) is used globally by 194 WHO member nations. It is used for assigning clinical diagnoses, providing... (Source: BMC Medicine)
Source: BMC Medicine - May 14, 2019 Category: Internal Medicine Authors: Ang élica M. Claudino, Kathleen M. Pike, Phillipa Hay, Jared W. Keeley, Spencer C. Evans, Tahilia J. Rebello, Rachel Bryant-Waugh, Yunfei Dai, Min Zhao, Chihiro Matsumoto, Cecile Rausch Herscovici, Blanca Mellor-Marsá, Anne-Claire Stona, Cary S. Kogan, Tags: Research article Source Type: research

Variation in health system performance for managing diabetes among states in India: a cross-sectional study of individuals aged 15 to 49  years
Understanding where adults with diabetes in India are lost in the diabetes care cascade is essential for the design of targeted health interventions and to monitor progress in health system performance for man... (Source: BMC Medicine)
Source: BMC Medicine - May 13, 2019 Category: Internal Medicine Authors: Jonas Prenissl, Lindsay M. Jaacks, Viswanathan Mohan, Jennifer Manne-Goehler, Justine I. Davies, Ashish Awasthi, Anne Christine Bischops, Rifat Atun, Till B ärnighausen, Sebastian Vollmer and Pascal Geldsetzer Tags: Research article Source Type: research

Recent advances in triple negative breast cancer: the immunotherapy era
Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plu... (Source: BMC Medicine)
Source: BMC Medicine - May 9, 2019 Category: Internal Medicine Authors: Antonio Marra, Giulia Viale and Giuseppe Curigliano Tags: Minireview Source Type: research

Vedolizumab trough level monitoring in inflammatory bowel disease: a state-of-the-art overview
Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with... (Source: BMC Medicine)
Source: BMC Medicine - May 8, 2019 Category: Internal Medicine Authors: Lieven Pouillon, S éverine Vermeire and Peter Bossuyt Tags: Minireview Source Type: research

Knowledge translation in health: how implementation science could contribute more
Despite increasing interest in research on how to translate knowledge into practice and improve healthcare, the accumulation of scientific knowledge in this field is slow. Few substantial new insights have bec... (Source: BMC Medicine)
Source: BMC Medicine - May 7, 2019 Category: Internal Medicine Authors: Michel Wensing and Richard Grol Tags: Opinion Source Type: research

DECIDE: a cluster-randomized controlled trial to reduce unnecessary caesarean deliveries in Burkina Faso
In Burkina Faso, facility-based caesarean delivery rates have markedly increased since the national subsidy policy for deliveries and emergency obstetric care was implemented in 2006. Effective and safe strate... (Source: BMC Medicine)
Source: BMC Medicine - May 2, 2019 Category: Internal Medicine Authors: Charles Kabor é, Valéry Ridde, Nils Chaillet, Fadima Yaya Bocoum, Ana Pilar Betrán and Alexandre Dumont Tags: Research article Source Type: research

Elevated plasma copeptin levels identify the presence and severity of non-alcoholic fatty liver disease in obesity
Copeptin is the stable surrogate marker of vasopressin (VP), which is released in response to elevated plasma osmolality or low blood pressure. Elevated plasma copeptin levels are associated with higher risk o... (Source: BMC Medicine)
Source: BMC Medicine - April 30, 2019 Category: Internal Medicine Authors: Ilaria Barchetta, Sofia Enh örning, Flavia Agata Cimini, Danila Capoccia, Caterina Chiappetta, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Olle Melander and Maria Gisella Cavallo Tags: Research article Source Type: research

Ethical challenges in global health-related stigma research
It is critically important to conduct research on stigmatized conditions, to include marginalized groups that experience stigma, and to develop interventions to reduce stigma. However, such research is ethical... (Source: BMC Medicine)
Source: BMC Medicine - April 29, 2019 Category: Internal Medicine Authors: Joseph Millum, Megan Campbell, Florencia Luna, Arianne Malekzadeh and Quarraisha Abdool Karim Tags: Correspondence Source Type: research

Mortality associated with alternative primary healthcare policies: a nationwide microsimulation modelling study in Brazil
Brazil ’s Estratégia Saúde da Família (ESF) is one of the largest and most robustly evaluated primary healthcare programmes of the world, but it could be affected by fiscal austerity measures and by the possible e... (Source: BMC Medicine)
Source: BMC Medicine - April 26, 2019 Category: Internal Medicine Authors: Davide Rasella, Thomas Hone, Luis Eugenio de Souza, Renato Tasca, Sanjay Basu and Christopher Millett Tags: Research article Source Type: research

Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study
Resistant hypertension is independently associated with an increased risk of death in the general hypertensive population. We assessed whether resistant hypertension is an independent predictor of all-cause mo... (Source: BMC Medicine)
Source: BMC Medicine - April 25, 2019 Category: Internal Medicine Authors: Anna Solini, Giuseppe Penno, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Marco G. Baroni, Antonio Nicolucci and Giuseppe Pugliese Tags: Research article Source Type: research

Population-level mathematical modeling of antimicrobial resistance: a systematic review
Mathematical transmission models are increasingly used to guide public health interventions for infectious diseases, particularly in the context of emerging pathogens; however, the contribution of modeling to ... (Source: BMC Medicine)
Source: BMC Medicine - April 24, 2019 Category: Internal Medicine Authors: Anna Maria Niewiadomska, Bamini Jayabalasingham, Jessica C. Seidman, Lander Willem, Bryan Grenfell, David Spiro and Cecile Viboud Tags: Research article Source Type: research

Data management and sharing policy: the first step towards promoting data sharing
Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared dat... (Source: BMC Medicine)
Source: BMC Medicine - April 17, 2019 Category: Internal Medicine Authors: Naomi Waithira, Brian Mutinda and Phaik Yeong Cheah Tags: Opinion Source Type: research

Prospective association between ultra-processed food consumption and incident depressive symptoms in the French NutriNet-Sant é cohort
Ultra-processed food (UPF) consumption has increased over the last decades in Westernized countries. Our objective was to investigate for the first time the association between the proportion of UPF (%UPF) in ... (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2019 Category: Internal Medicine Authors: Moufidath Adjibade, Chantal Julia, Benjamin All ès, Mathilde Touvier, Cédric Lemogne, Bernard Srour, Serge Hercberg, Pilar Galan, Karen E. Assmann and Emmanuelle Kesse-Guyot Tags: Research article Source Type: research

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study
It is unclear what to do when people with type 2 diabetes have had no or a limited glycemic response to a recently introduced medication. Intra-individual HbA1c variability can obscure true response. Some guid... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2019 Category: Internal Medicine Authors: Andrew P. McGovern, John M. Dennis, Beverley M. Shields, Andrew T. Hattersley, Ewan R. Pearson and Angus G. Jones Tags: Research article Source Type: research

Exploring telomere length in mother –newborn pairs in relation to exposure to multiple toxic metals and potential modifying effects by nutritional factors
The uterine environment may influence telomere length at birth, which is essential for cellular function, aging, and disease susceptibility over the lifespan. However, little is known about the impact of toxic... (Source: BMC Medicine)
Source: BMC Medicine - April 11, 2019 Category: Internal Medicine Authors: Maria Herlin, Karin Broberg, Annachiara Malin Igra, Huiqi Li, Florencia Harari and Marie Vahter Tags: Research article Source Type: research

Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort
Multimorbidity is associated with higher mortality, but the relationship with cancer and cardiovascular mortality is unclear. The influence of demographics and type of condition on the relationship of multimor... (Source: BMC Medicine)
Source: BMC Medicine - April 10, 2019 Category: Internal Medicine Authors: Bhautesh Dinesh Jani, Peter Hanlon, Barbara I. Nicholl, Ross McQueenie, Katie I. Gallacher, Duncan Lee and Frances S. Mair Tags: Research article Source Type: research

A step beyond the hygiene hypothesis —immune-mediated classes determined in a population-based study
Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the h... (Source: BMC Medicine)
Source: BMC Medicine - April 9, 2019 Category: Internal Medicine Authors: Vladeta Ajdacic-Gross, Margot Mutsch, Stephanie Rodgers, Anja Tesic, Mario M üller, Erich Seifritz, En-Young N. Wagner, Roland von Känel, Markus A. Landolt, Nina Steinemann, Viktor von Wyl, Enrique Castelao, Marie-Pierre F. Strippoli, Jennifer Glaus, Ca Tags: Research article Source Type: research

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study
Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic range can be challenging. In a previous trial, we s... (Source: BMC Medicine)
Source: BMC Medicine - April 8, 2019 Category: Internal Medicine Authors: Andrea L. Jorgensen, Clare Prince, Gail Fitzgerald, Anita Hanson, Jennifer Downing, Julia Reynolds, J. Eunice Zhang, Ana Alfirevic and Munir Pirmohamed Tags: Research article Source Type: research

Predicting COPD 1-year mortality using prognostic predictors routinely measured in primary care
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality. Patients with advanced disease often have a poor quality of life, such that guidelines recommend providing palliative care in their l... (Source: BMC Medicine)
Source: BMC Medicine - April 5, 2019 Category: Internal Medicine Authors: C. I. Bloom, F. Ricciardi, L. Smeeth, P. Stone and J. K. Quint Tags: Research article Source Type: research

B-type natriuretic peptide trumps other prognostic markers in patients assessed for coronary disease
Risk prediction for patients with suspected coronary artery disease is complex due to the common occurrence of prior cardiovascular disease and extensive risk modification in primary care. Numerous markers hav... (Source: BMC Medicine)
Source: BMC Medicine - April 3, 2019 Category: Internal Medicine Authors: Dipak Kotecha, Marcus D. Flather, Dan Atar, Peter Collins, John Pepper, Elizabeth Jenkins, Christopher M. Reid and David Eccleston Tags: Research article Source Type: research

Improving engagement with healthcare in hepatitis C: a randomised controlled trial of a peer support intervention
Peer support can enable patient engagement with healthcare services, particularly for marginalised populations. In this randomised controlled trial, the efficacy of a peer support intervention at promoting suc... (Source: BMC Medicine)
Source: BMC Medicine - April 1, 2019 Category: Internal Medicine Authors: Helen R. Stagg, Julian Surey, Marie Francis, Jennifer MacLellan, Graham R. Foster, Andr é Charlett and Ibrahim Abubakar Tags: Research article Source Type: research

Microbiology Investigation Criteria for Reporting Objectively (MICRO): a framework for the reporting and interpretation of clinical microbiology data
There is a pressing need to understand better the extent and distribution of antimicrobial resistance on a global scale, to inform development of effective interventions. Collation of datasets for meta-analysi... (Source: BMC Medicine)
Source: BMC Medicine - March 29, 2019 Category: Internal Medicine Authors: Paul Turner, Andrew Fox-Lewis, Poojan Shrestha, David A. B. Dance, Tri Wangrangsimakul, Tomas-Paul Cusack, Clare L. Ling, Jill Hopkins, Tamalee Roberts, Direk Limmathurotsakul, Ben S. Cooper, Susanna Dunachie, Catrin E. Moore, Christiane Dolecek, H. Rogie Tags: Guideline Source Type: research

Profiling the best-performing community medicine distributors for mass drug administration: a comprehensive, data-driven analysis of treatment for schistosomiasis, lymphatic filariasis, and soil-transmitted helminths in Uganda
The most prevalent neglected tropical diseases are treated through blanket drug distribution that is reliant on lay community medicine distributors (CMDs). Yet, treatment rates achieved by CMDs vary widely and... (Source: BMC Medicine)
Source: BMC Medicine - March 28, 2019 Category: Internal Medicine Authors: Goylette F. Chami, Narcis B. Kabatereine and Edridah M. Tukahebwa Tags: Research article Source Type: research

‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare
Blockchain is a shared distributed digital ledger technology that can better facilitate data management, provenance and security, and has the potential to transform healthcare. Importantly, blockchain represen... (Source: BMC Medicine)
Source: BMC Medicine - March 27, 2019 Category: Internal Medicine Authors: Tim K. Mackey, Tsung-Ting Kuo, Basker Gummadi, Kevin A. Clauson, George Church, Dennis Grishin, Kamal Obbad, Robert Barkovich and Maria Palombini Tags: Forum Source Type: research

Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis
Statins may prevent recurrent ischemic events after ischemic stroke. Determining which statin to use remains controversial. We aimed to summarize the evidence for the use of statins in secondary prevention for... (Source: BMC Medicine)
Source: BMC Medicine - March 26, 2019 Category: Internal Medicine Authors: Irene Tramacere, Giorgio B. Boncoraglio, Rita Banzi, Cinzia Del Giovane, Koren H. Kwag, Alessandro Squizzato and Lorenzo Moja Tags: Research article Source Type: research

Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: a large international population-based cohort study
Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based stud... (Source: BMC Medicine)
Source: BMC Medicine - March 25, 2019 Category: Internal Medicine Authors: Lei Huang, Yesilda Balavarca, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Vesna Zadnik, Maja Primic- Žakelj, Margit Mägi, Robert Grützmann, Marc G. Besselink, Petra Schrotz-King, Hermann Brenner and Tags: Research article Source Type: research

Specialist palliative care support is associated with improved pain relief at home during the last 3  months of life in patients with advanced disease: analysis of 5-year data from the national survey of bereaved people (VOICES)
Studies have shown that more than half of patients with advanced progressive diseases approaching the end-of-life report pain and that pain relief for these patients is poorest at home compared to other care s... (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2019 Category: Internal Medicine Authors: Yousuf ElMokhallalati, Natalie Woodhouse, Tracey Farragher and Michael I. Bennett Tags: Research article Source Type: research

Comparison of depression prevalence estimates in meta-analyses based on screening tools and rating scales versus diagnostic interviews: a meta-research review
Depression symptom questionnaires are commonly used to assess symptom severity and as screening tools to identify patients who may have depression. They are not designed to ascertain diagnostic status and, bas... (Source: BMC Medicine)
Source: BMC Medicine - March 21, 2019 Category: Internal Medicine Authors: Brooke Levis, Xin Wei Yan, Chen He, Ying Sun, Andrea Benedetti and Brett D. Thombs Tags: Research article Source Type: research

ApoE4: an emerging therapeutic target for Alzheimer ’s disease
The growing body of evidence indicating the heterogeneity of Alzheimer ’s disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy, suggest that the development of a single ma... (Source: BMC Medicine)
Source: BMC Medicine - March 20, 2019 Category: Internal Medicine Authors: Mirna Safieh, Amos D. Korczyn and Daniel M. Michaelson Tags: Review Source Type: research