sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country
Few studies of biomarkers as predictors of outcome in infection have been performed in tropical, low- and middle-income countries where the burden of sepsis is highest. We evaluated whether selected biomarkers... (Source: BMC Medicine)
Source: BMC Medicine - July 1, 2020 Category: Internal Medicine Authors: Shelton W. Wright, Lara Lovelace-Macon, Viriya Hantrakun, Kristina E. Rudd, Prapit Teparrukkul, Susanna Kosamo, W. Conrad Liles, Direk Limmathurotsakul and T. Eoin West Tags: Research article Source Type: research

Ethnicity and COVID-19 infection: are the pieces of the puzzle falling into place?
(Source: BMC Medicine)
Source: BMC Medicine - July 1, 2020 Category: Internal Medicine Authors: Rachel H. Mulholland and Ian P. Sinha Tags: Commentary Source Type: research

Multidrug-resistant tuberculosis surveillance and cascade of care in Madagascar: a five-year (2012 –2017) retrospective study
In Madagascar, the multidrug-resistant tuberculosis (MDR-TB) surveillance programme was launched in late 2012 wherein previously treated TB cases and symptomatic MDR-TB contacts (hereafter called presumptive M... (Source: BMC Medicine)
Source: BMC Medicine - June 30, 2020 Category: Internal Medicine Authors: Astrid M. Knoblauch, Simon Grandjean Lapierre, Daniella Randriamanana, Mamy Serge Raherison, Andrianantenaina Rakotoson, Bienvenue Solofomandimby Raholijaona, Masiarivony Ravaoarimanga, Pascaline Elisabeth Ravololonandriana, Marie-Sylvianne Rabodoarivelo, Tags: Research article Source Type: research

A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma
Pancreatic cancer is refractory to most current treatment options. Immunotherapy emerges as an effective and novel therapeutic strategy for several solid tumors. However, most of the clinical trials on immunot... (Source: BMC Medicine)
Source: BMC Medicine - June 29, 2020 Category: Internal Medicine Authors: Courtney W. Houchen and Min Li Tags: Commentary Source Type: research

Forecasting spatial, socioeconomic and demographic variation in COVID-19 health care demand in England and Wales
COVID-19 poses one of the most profound public health crises for a hundred years. As of mid-May 2020, across the world, almost 300,000 deaths and over 4 million confirmed cases were registered. Reaching over 3... (Source: BMC Medicine)
Source: BMC Medicine - June 29, 2020 Category: Internal Medicine Authors: Mark D. Verhagen, David M. Brazel, Jennifer Beam Dowd, Ilya Kashnitsky and Melinda C. Mills Tags: Research article Source Type: research

Correction to: The complex neurobiology of resilient functioning after childhood maltreatment
An amendment to this paper has been published and can be accessed via the original article. (Source: BMC Medicine)
Source: BMC Medicine - June 27, 2020 Category: Internal Medicine Authors: Konstantinos Ioannidis, Adrian Dahl Askelund, Rogier A. Kievit and Anne-Laura van Harmelen Tags: Correction Source Type: research

Risk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies
There is a clear need for systematic appraisal of models/factors predicting colorectal cancer (CRC) metastasis and recurrence because clinical decisions about adjuvant treatment are taken on the basis of such ... (Source: BMC Medicine)
Source: BMC Medicine - June 26, 2020 Category: Internal Medicine Authors: Wei Xu, Yazhou He, Yuming Wang, Xue Li, Jane Young, John P. A. Ioannidis, Malcolm G. Dunlop and Evropi Theodoratou Tags: Research article Source Type: research

Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review
Major infectious disease outbreaks are a constant threat to human health. Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. Experiences from previous epidemic... (Source: BMC Medicine)
Source: BMC Medicine - June 25, 2020 Category: Internal Medicine Authors: Louise Sigfrid, Katherine Maskell, Peter G. Bannister, Sharif A. Ismail, Shelui Collinson, Sadie Regmi, Claire Blackmore, Eli Harriss, Kajsa-Stina Longuere, Nina Gobat, Peter Horby, Mike Clarke and Gail Carson Tags: Research article Source Type: research

A prospect on the use of antiviral drugs to control local outbreaks of COVID-19
Current outbreaks of COVID-19 are threatening the health care systems of several countries around the world. Control measures, based on isolation, contact tracing, and quarantine, can decrease and delay the bu... (Source: BMC Medicine)
Source: BMC Medicine - June 25, 2020 Category: Internal Medicine Authors: Andrea Torneri, Pieter Libin, Joris Vanderlocht, Anne-Mieke Vandamme, Johan Neyts and Niel Hens Tags: Research article Source Type: research

Rapid publications risk the integrity of science in the era of COVID-19
Preprint manuscripts, rapid publications and opinion pieces have been essential in permitting the lay press and public health authorities to preview data relating to coronavirus disease 2019 (COVID-19), includ... (Source: BMC Medicine)
Source: BMC Medicine - June 25, 2020 Category: Internal Medicine Authors: N. Bagdasarian, G. B. Cross and D. Fisher Tags: Opinion Source Type: research

Why the COVID-19 pandemic should be a call for action to advance equitable access to medicines
(Source: BMC Medicine)
Source: BMC Medicine - June 25, 2020 Category: Internal Medicine Authors: Jillian C. Kohler and Tim K. Mackey Tags: Commentary Source Type: research

Mental health and smoking cessation —a population survey in England
To reduce inequalities between individuals with and without mental health problems, a better understanding is required of triggers and success of quit attempts among the third of smokers with mental health pro... (Source: BMC Medicine)
Source: BMC Medicine - June 25, 2020 Category: Internal Medicine Authors: Leonie S. Brose, Jamie Brown and Ann McNeill Tags: Research article Source Type: research

Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: an overview of systematic reviews
There are no overviews of systematic reviews investigating haemoglobin thresholds for transfusion. This is important as the literature on transfusion thresholds has grown considerably in recent years. Our aim ... (Source: BMC Medicine)
Source: BMC Medicine - June 24, 2020 Category: Internal Medicine Authors: Kevin M. Trentino, Shannon L. Farmer, Michael F. Leahy, Frank M. Sanfilippo, James P. Isbister, Rhonda Mayberry, Axel Hofmann, Aryeh Shander, Craig French and Kevin Murray Tags: Research article Source Type: research

Programmatic options for monitoring malaria in elimination settings: easy access group surveys to investigate Plasmodium falciparum epidemiology in two regions with differing endemicity in Haiti
As in most eliminating countries, malaria transmission is highly focal in Haiti. More granular information, including identifying asymptomatic infections, is needed to inform programmatic efforts, monitor inte... (Source: BMC Medicine)
Source: BMC Medicine - June 23, 2020 Category: Internal Medicine Authors: Thomas Druetz, Gillian Stresman, Ruth A. Ashton, Lotus L. van den Hoogen, Vena Joseph, Carl Fayette, Frank Monestime, Karen E. Hamre, Michelle A. Chang, Jean F. Lemoine, Chris Drakeley and Thomas P. Eisele Tags: Research article Source Type: research

Bevacizumab dose adjustment to improve clinical outcomes of glioblastoma
Glioblastoma (GBM) is one of the most aggressive and vascularized brain tumors in adults, with a median survival of 20.9  months. In newly diagnosed and recurrent GBM, bevacizumab demonstrated an increase in pr... (Source: BMC Medicine)
Source: BMC Medicine - June 22, 2020 Category: Internal Medicine Authors: N. Garc ía-Romero, I. Palacín-Aliana, R. Madurga, J. Carrión-Navarro, S. Esteban-Rubio, B. Jiménez, A. Collazo, F. Pérez-Rodríguez, A. Ortiz de Mendivil, C. Fernández-Carballal, S. García-Duque, J. Diamantopoulos-Fernández, C. Belda-Iniesta, R. P Tags: Research article Source Type: research

To screen or not to screen: an interactive framework for comparing costs of mass malaria treatment interventions
Mass drug administration and mass-screen-and-treat interventions have been used to interrupt malaria transmission and reduce burden in sub-Saharan Africa. Determining which strategy will reduce costs is an imp... (Source: BMC Medicine)
Source: BMC Medicine - June 19, 2020 Category: Internal Medicine Authors: Justin Millar, Kok Ben Toh and Denis Valle Tags: Research article Source Type: research

Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease
Prion disease is neurodegenerative disease that is typically fatal within months of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have proven challenging. Individuals... (Source: BMC Medicine)
Source: BMC Medicine - June 18, 2020 Category: Internal Medicine Authors: Sonia M. Vallabh, Eric Vallabh Minikel, Victoria J. Williams, Becky C. Carlyle, Alison J. McManus, Chase D. Wennick, Anna Bolling, Bianca A. Trombetta, David Urick, Chloe K. Nobuhara, Jessica Gerber, Holly Duddy, Ingolf Lachmann, Christiane Stehmann, Stev Tags: Research article Source Type: research

A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
A connection between amyotrophic lateral sclerosis (ALS) and altered gut microbiota composition has previously been reported in animal models. This work is the first prospective longitudinal study addressing t... (Source: BMC Medicine)
Source: BMC Medicine - June 17, 2020 Category: Internal Medicine Authors: Diana Di Gioia, Nicole Bozzi Cionci, Loredana Baffoni, Angela Amoruso, Marco Pane, Luca Mogna, Francesca Gagg ìa, Maria Ausiliatrice Lucenti, Enrica Bersano, Roberto Cantello, Fabiola De Marchi and Letizia Mazzini Tags: Research article Source Type: research

Comparative performance and external validation of the multivariable PREDICT Prostate tool for non-metastatic prostate cancer: a study in 69,206 men from Prostate Cancer data Base Sweden (PCBaSe)
PREDICT Prostate is an endorsed prognostic model that provides individualised long-term prostate cancer-specific and overall survival estimates. The model, derived from UK data, estimates potential treatment bene... (Source: BMC Medicine)
Source: BMC Medicine - June 16, 2020 Category: Internal Medicine Authors: David Thurtle, Ola Bratt, P är Stattin, Paul Pharoah and Vincent Gnanapragasam Tags: Research article Source Type: research

Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency state in humans. The clinical phenotype is variable and includes asymptomatic individuals, episodic hemolysis induced by... (Source: BMC Medicine)
Source: BMC Medicine - June 15, 2020 Category: Internal Medicine Authors: James J. Gilchrist, Sophie Uyoga, Matti Pirinen, Anna Rautanen, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Adrian V. S. Hill, J. Anthony G. Scott and Thomas N. Williams Tags: Research article Source Type: research

Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK Biobank
Child maltreatment is associated with cardiovascular disease (CVD), but mediation pathways have not been fully elucidated. The aim of the current study was to determine and quantify the underlying pathways lin... (Source: BMC Medicine)
Source: BMC Medicine - June 12, 2020 Category: Internal Medicine Authors: Frederick K. Ho, Carlos Celis-Morales, Stuart R. Gray, Fanny Petermann-Rocha, Donald Lyall, Daniel Mackay, Naveed Sattar, Helen Minnis and Jill P. Pell Tags: Research article Source Type: research

Using health facility deaths to estimate population causes of neonatal and child mortality in four African countries
Verbal autopsy is the main method used in countries with weak civil registration systems for estimating community causes of neonatal and 1 –59-month-old deaths. However, validation studies of verbal autopsy met... (Source: BMC Medicine)
Source: BMC Medicine - June 12, 2020 Category: Internal Medicine Authors: Henry D. Kalter, Jamie Perin, Agbessi Amouzou, Gift Kwamdera, Wasilat Adeyinka Adewemimo, F élicitée Nguefack, Abdoulaye-Mamadou Roubanatou and Robert E. Black Tags: Research article Source Type: research

Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort
Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on ... (Source: BMC Medicine)
Source: BMC Medicine - June 11, 2020 Category: Internal Medicine Authors: Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A. Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel A. B. Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli Tags: Research article Source Type: research

Estimating the contribution of different age strata to vaccine serotype pneumococcal transmission in the pre vaccine era: a modelling study
Herd protection through interruption of transmission has contributed greatly to the impact of pneumococcal conjugate vaccines (PCVs) and may enable the use of cost-saving reduced dose schedules. To aid PCV age... (Source: BMC Medicine)
Source: BMC Medicine - June 10, 2020 Category: Internal Medicine Authors: Stefan Flasche, Marc Lipsitch, John Ojal and Amy Pinsent Tags: Research article Source Type: research

COVID-19 cancer conundrum —evidence driving decisions or the lack of it?
(Source: BMC Medicine)
Source: BMC Medicine - June 9, 2020 Category: Internal Medicine Authors: Nalinie Joharatnam-Hogan and Khurum Khan Tags: Commentary Source Type: research

Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach
This study combined genetic designs with longitudinal data to ... (Source: BMC Medicine)
Source: BMC Medicine - June 9, 2020 Category: Internal Medicine Authors: Ida K. Karlsson, Kelli Lehto, Margaret Gatz, Chandra A. Reynolds and Anna K. Dahl Aslan Tags: Research article Source Type: research

Current practice in analysing and reporting binary outcome data —a review of randomised controlled trial reports
Randomised controlled trials (RCTs) need to be reported so that their results can be unambiguously and robustly interpreted. Binary outcomes yield unique challenges, as different analytical approaches may prod... (Source: BMC Medicine)
Source: BMC Medicine - June 8, 2020 Category: Internal Medicine Authors: Ines Rombach, Ruth Knight, Nicholas Peckham, Jamie R. Stokes and Jonathan A. Cook Tags: Research article Source Type: research

Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore
On January 30, COVID-19 was declared a Public Health Emergency of International Concern —a week after Singapore’s first imported case and 5 days before local transmission. The National University Hospital (NUH)... (Source: BMC Medicine)
Source: BMC Medicine - June 8, 2020 Category: Internal Medicine Authors: Sophia Archuleta, Gail Cross, Jyoti Somani, Lionel Lum, Amelia Santosa, Rawan A. Alagha, David M. Allen, Alicia Ang, Darius Beh, Louis Chai, Si Min Chan, See Ming Lim, Dariusz P. Olszyna, Catherine Ong, Jolene Oon, Brenda M. A. Salada & hellip; Tags: Correspondence Source Type: research

Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection
Accurate and noninvasive diagnosis and staging of liver fibrosis are essential for effective clinical management of chronic liver disease (CLD). We aimed to identify serum metabolite markers that reliably pred... (Source: BMC Medicine)
Source: BMC Medicine - June 5, 2020 Category: Internal Medicine Authors: Guoxiang Xie, Xiaoning Wang, Runmin Wei, Jingye Wang, Aihua Zhao, Tianlu Chen, Yixing Wang, Hua Zhang, Zhun Xiao, Xinzhu Liu, Youping Deng, Linda Wong, Cynthia Rajani, Sandi Kwee, Hua Bian, Xin Gao & hellip; Tags: Research article Source Type: research

Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry
Antidepressant medication (ADM) and psychotherapy are effective treatments for major depressive disorder (MDD). It is unclear, however, if treatments differ in their effectiveness at the symptom level and whet... (Source: BMC Medicine)
Source: BMC Medicine - June 5, 2020 Category: Internal Medicine Authors: Nils Kappelmann, Martin Rein, Julia Fietz, Helen S. Mayberg, W. Edward Craighead, Boadie W. Dunlop, Charles B. Nemeroff, Martin Keller, Daniel N. Klein, Bruce A. Arnow, Nusrat Husain, Robin B. Jarrett, Jeffrey R. Vittengl, Marco Menchetti, Gordon Parker, Tags: Registered report Source Type: research

The role of pulmonary CT scans for children during the COVID-19 pandemic
(Source: BMC Medicine)
Source: BMC Medicine - June 5, 2020 Category: Internal Medicine Authors: Ian P. Sinha and Musa Kaleem Tags: Commentary Source Type: research

The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank
Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific evolutionary biology trade-off between reproduction and lo... (Source: BMC Medicine)
Source: BMC Medicine - June 4, 2020 Category: Internal Medicine Authors: Jie V. Zhao and C. Mary Schooling Tags: Research article Source Type: research

Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial
The EXAMINE trial tested the efficacy and safety of alogliptin, an inhibitor of dipeptidyl peptidase 4, compared with placebo in 5380 patients with type 2 diabetes and a recent acute coronary syndrome. Because... (Source: BMC Medicine)
Source: BMC Medicine - June 4, 2020 Category: Internal Medicine Authors: Jo ão Pedro Ferreira, Cyrus Mehta, Abhinav Sharma, Steven E. Nissen, Patrick Rossignol and Faiez Zannad Tags: Research article Source Type: research

Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study
Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they presen... (Source: BMC Medicine)
Source: BMC Medicine - June 3, 2020 Category: Internal Medicine Authors: Jichan Shi, Yang Li, Xian Zhou, Qiran Zhang, Xinchun Ye, Zhengxing Wu, Xiangao Jiang, Hongying Yu, Lingyun Shao, Jing-Wen Ai, Haocheng Zhang, Bin Xu, Feng Sun and Wenhong Zhang Tags: Research article Source Type: research

The challenges of colposcopy for cervical cancer screening in LMICs and solutions by artificial intelligence
The World Health Organization (WHO) called for global action towards the elimination of cervical cancer. One of the main strategies is to screen 70% of women at the age between 35 and 45  years and 90% of women... (Source: BMC Medicine)
Source: BMC Medicine - June 3, 2020 Category: Internal Medicine Authors: Peng Xue, Man Tat Alexander Ng and Youlin Qiao Tags: Opinion Source Type: research

Routine data for malaria morbidity estimation in Africa: challenges and prospects
The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact of investments and providing an in-depth analysis of progress and trends i... (Source: BMC Medicine)
Source: BMC Medicine - June 3, 2020 Category: Internal Medicine Authors: Victor A. Alegana, Emelda A. Okiro and Robert W. Snow Tags: Opinion Source Type: research

Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Malaria in pregnancy, including asymptomatic infection, has a detrimental impact on foetal development. Individual patient data (IPD) meta-analysis was conducted to compare the association between antimalarial... (Source: BMC Medicine)
Source: BMC Medicine - June 2, 2020 Category: Internal Medicine Authors: Makoto Saito, Rashid Mansoor, Kalynn Kennon, Anupkumar R. Anvikar, Elizabeth A. Ashley, Daniel Chandramohan, Lauren M. Cohee, Umberto D ’Alessandro, Blaise Genton, Mary Ellen Gilder, Elizabeth Juma, Linda Kalilani-Phiri, Irene Kuepfer, Miriam K. Laufer, Tags: Research article Source Type: research

Conduct and reporting of individual participant data network meta-analyses need improvement
(Source: BMC Medicine)
Source: BMC Medicine - June 2, 2020 Category: Internal Medicine Authors: Anna Chaimani Tags: Commentary Source Type: research

Statistical analyses and quality of individual participant data network meta-analyses were suboptimal: a cross-sectional study
Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for... (Source: BMC Medicine)
Source: BMC Medicine - June 1, 2020 Category: Internal Medicine Authors: Ya Gao, Shuzhen Shi, Muyang Li, Xinyue Luo, Ming Liu, Kelu Yang, Junhua Zhang, Fujian Song and Jinhui Tian Tags: Research article Source Type: research

Evidence of unexplained discrepancies between planned and conducted statistical analyses: a review of randomised trials
Choosing or altering the planned statistical analysis approach after examination of trial data (often referred to as ‘p-hacking’) can bias the results of randomised trials. However, the extent of this issue in... (Source: BMC Medicine)
Source: BMC Medicine - May 29, 2020 Category: Internal Medicine Authors: Suzie Cro, Gordon Forbes, Nicholas A. Johnson and Brennan C. Kahan Tags: Research article Source Type: research

Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank
Understanding of the role of ethnicity and socioeconomic position in the risk of developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study. (Source: BMC Medicine)
Source: BMC Medicine - May 29, 2020 Category: Internal Medicine Authors: Claire L. Niedzwiedz, Catherine A. O ’Donnell, Bhautesh Dinesh Jani, Evangelia Demou, Frederick K. Ho, Carlos Celis-Morales, Barbara I. Nicholl, Frances S. Mair, Paul Welsh, Naveed Sattar, Jill P. Pell and S. Vittal Katikireddi Tags: Research article Source Type: research

Risk stratification for prostate cancer management: value of the Cambridge Prognostic Group classification for assessing treatment allocation
The five-tiered Cambridge Prognostic Group (CPG) classification is a better predictor of prostate cancer-specific mortality than the traditional three-tiered classification (low, intermediate, and high risk). ... (Source: BMC Medicine)
Source: BMC Medicine - May 28, 2020 Category: Internal Medicine Authors: M. G. Parry, T. E. Cowling, A. Sujenthiran, J. Nossiter, B. Berry, P. Cathcart, A. Aggarwal, H. Payne, J. van der Meulen, N. W. Clarke and V. J. Gnanapragasam Tags: Research article Source Type: research

Diagnosis of COVID-19 in children: the story evolves
(Source: BMC Medicine)
Source: BMC Medicine - May 28, 2020 Category: Internal Medicine Authors: R. Harwood and I. Sinha Tags: Commentary Source Type: research

Serum free thiols predict cardiovascular events and all-cause mortality in the general population: a prospective cohort study
Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative stress. Since serum free thiols are rapidly oxidized by reactive species, systemic oxidative stress is generally associated with ... (Source: BMC Medicine)
Source: BMC Medicine - May 27, 2020 Category: Internal Medicine Authors: Amaal E. Abdulle, Arno R. Bourgonje, Lyanne M. Kieneker, Anne M. Koning, S. la Bastide-van Gemert, Marian L. C. Bulthuis, Gerard Dijkstra, Klaas Nico Faber, Robin P. F. Dullaart, Stephan J. L. Bakker, Reinold O. B. Gans, Ron T. Gansevoort, Douwe J. Mulder Tags: Research article Source Type: research

Evaluation of the potential incidence of COVID-19 and effectiveness of containment measures in Spain: a data-driven approach
We are currently experiencing an unprecedented challenge, managing and containing an outbreak of a new coronavirus disease known as COVID-19. While China —where the outbreak started—seems to have been able to c... (Source: BMC Medicine)
Source: BMC Medicine - May 27, 2020 Category: Internal Medicine Authors: Alberto Aleta and Yamir Moreno Tags: Research Article Source Type: research

Children ’s microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease
Particulate matter exposure during in utero life may entail adverse health outcomes later in life. The microvasculature undergoes extensive, organ-specific prenatal maturation. A growing body of evidence shows th... (Source: BMC Medicine)
Source: BMC Medicine - May 26, 2020 Category: Internal Medicine Authors: Leen J. Luyten, Yinthe Dockx, Eline B. Provost, Narjes Madhloum, Hanne Sleurs, Kristof Y. Neven, Bram G. Janssen, Hannelore Bov é, Florence Debacq-Chainiaux, Nele Gerrits, Wouter Lefebvre, Michelle Plusquin, Charlotte Vanpoucke, Patrick De Boever and Tim Tags: Research article Source Type: research

Guidance for identification and treatment of individuals with attention deficit/hyperactivity disorder and autism spectrum disorder based upon expert consensus
Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are estab... (Source: BMC Medicine)
Source: BMC Medicine - May 25, 2020 Category: Internal Medicine Authors: Susan Young, Jack Hollingdale, Michael Absoud, Patrick Bolton, Polly Branney, William Colley, Emily Craze, Mayuri Dave, Quinton Deeley, Emad Farrag, Gisli Gudjonsson, Peter Hill, Ho-lan Liang, Clodagh Murphy, Peri Mackintosh, Marianna Murin & hellip; Tags: Guideline Source Type: research

Epidemiological models are important tools for guiding COVID-19 interventions
(Source: BMC Medicine)
Source: BMC Medicine - May 25, 2020 Category: Internal Medicine Authors: Robin N. Thompson Tags: MedViews Source Type: research

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth
Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted and acidemic, and can demise. Preterm fetal growth restriction is a severe form of placen... (Source: BMC Medicine)
Source: BMC Medicine - May 22, 2020 Category: Internal Medicine Authors: Natalie J. Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L. David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock & hell Tags: Research article Source Type: research

Africa ’s response to COVID-19
(Source: BMC Medicine)
Source: BMC Medicine - May 22, 2020 Category: Internal Medicine Authors: Chikwe Ihekweazu and Emmanuel Agogo Tags: Commentary Source Type: research