What are Common Causes of Anaphylaxis?
Discussion
Anaphylaxis is a potentially life-threatening hypersensitivity reaction of the body. Usually anaphylaxis is IgE mediated but complement-mediated immune complex reactions or IgG mediated reactions can cause anaphylaxis. Usually mucous membranes or skin are involved, but it is a systemic disease process with at least 2 systems involved (respiratory is second most common followed by gastrointestinal system). The epidemiology is difficult to discern but the estimated incidence is about 50-112 episodes per 100,000 person-years and estimated prevalence is 0.3-5.1%. There is data supporting an increased incidence. Over...
Source: PediatricEducation.org - May 17, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Toxic brain edema and brain death after scorpion envenomation - G ün E, Botan E, Bektaş, Kendirli T.
Scorpion sting is common in some global regions and mostly causes local envenoming of varying severity. Some estimates suggest that perhaps only 10% of those stung by even the most medically important species develop severe systemic envenomation; however, ... (Source: SafetyLit)
Source: SafetyLit - May 12, 2021 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news
B.1.617 can duck antibodies, but vax blunts sting: Study
Covid-19 ’s so-called ‘Indian variant’ has a “modest” ability to “escape” the antibodies developed by vaccines, but it can, at best, cause moderate illness among those who have got the shots, scientists from India and the UK have found, establishing that “vaccination is still protective for t he majority of people”. (Source: The Economic Times)
Source: The Economic Times - May 12, 2021 Category: Consumer Health News Source Type: news
Clinical effects and factors associated with adverse clinical outcomes of hymenopteran stings treated in a Thai Poison Centre: a retrospective cross-sectional study - Srisuwarn P, Srisuma S, Sriapha C, Tongpoo A, Rittilert P, Pradoo A, Tanpudsa Y, Wananukul W.
OBJECTIVE: To describe clinical effects and outcomes of hymenopteran stings and to explore the non-laboratory factors associated with adverse clinical outcomes, a composite outcome including death, respiratory failure requiring intubation, acute kidney inj... (Source: SafetyLit)
Source: SafetyLit - May 11, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Moffitt researchers discover regulatory pathway that blocks immune response against cancer
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 11, 2021 Category: Cancer & Oncology Source Type: news
Cloaked by mutant p53
Mutant p53 takes the STING out of antitumor immunity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 11, 2021 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news
Free COVID-19 Vaccines Are Luring Visitors to Dracula ’s Castle in Transylvania
Residents of Romania who find themselves in central Transylvania this May now have the option of getting vaccinated at a legendary location from horror history: Bran Castle.
Every weekend this month, the fortress that’s believed to be the inspiration behind Count Dracula’s lair in Bram Stoker’s 19th-century gothic novel Dracula will be home to a free COVID-19 vaccination center where Romanians can get a Pfizer-BioNTech shot without making an appointment—or, as a Facebook post announcing the event put it, “another kind of sting.”
Daniel Mihailescu—AFP/Getty ImagesA banner reading &#...
Source: TIME: Health - May 10, 2021 Category: Consumer Health News Authors: Megan McCluskey Tags: Uncategorized Brief Vaccines Source Type: news
Former Oregon House speaker arrested in sex trafficking sting
David Hunt, 53, has denied allegations that he responded to online ads to arrange payment for sexual acts. (Source: Reuters: Health)
Source: Reuters: Health - May 5, 2021 Category: Consumer Health News Source Type: news
Mets hand Phillies crushing loss and move into first-place tie in NL East
The Phillies will be feeling the sting of their Sunday defeat for a while (Source: Reuters: Health)
Source: Reuters: Health - May 3, 2021 Category: Consumer Health News Source Type: news
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING
Protein function is regulated by posttranslational modifications (PTMs), among which reversible oxidation of cysteine residues has emerged as a key regulatory mechanism of cellular responses. Given the redox regulation of virus-host interactions, the identification of oxidized cysteine sites in cells is essential to understand the underlying mechanisms involved. Here, we present a proteome-wide identification of reversibly oxidized cysteine sites in oxidant-treated cells using a maleimide-based bioswitch method coupled to mass spectrometry analysis. We identified 2720 unique oxidized cysteine sites within 1473 proteins wit...
Source: Signal Transduction Knowledge Environment - April 27, 2021 Category: Science Authors: Zamorano Cuervo, N., Fortin, A., Caron, E., Chartier, S., Grandvaux, N. Tags: STKE Research Articles Source Type: news
NIH Awards BellBrook Labs Phase II Grant to Develop Drugs Targeting the cGAS-STING Pathway for Lupus and Related Autoimmune Diseases
The National Institute of Allergy and Infectious Diseases (NIAID) recently awarded BellBrook Labs a $1.8 million Phase II Small Business Innovative Research (SBIR) grant to develop small molecule... (Source: The Scientist)
Source: The Scientist - April 22, 2021 Category: Science Tags: The Scientist The Marketplace Source Type: news
Trillions of ‘Brood X’ Cicadas Are About to Emerge Across the U.S. to Sing, Mate and Die. Here’s What to Expect
This coming May, millions of people around the United States will have front-row seats to an extraordinary entomological event: Trillions of Brood X cicadas across 15 states will emerge almost synchronously after having spent the last 17 years underground. The males will take up elevated positions, each buzzing as loud as a lawnmower to attract females. After mating, the adult cicadas will die off en masse just about as quickly as they arrived—likely sometime in late June or July—while their offspring tunnel underground, not to emerge until 2038, when the dance will begin anew.
Annual, or “dog day,”...
Source: TIME: Science - April 14, 2021 Category: Science Authors: Rebecca Katzman Tags: Uncategorized animals Environment News Source Type: news
Gaetz's glare stings House GOP
The restraint from party leadership suggests it’s unlikely the Florida congressman will suffer any intra-party consequences until the... (Source: Reuters: Health)
Source: Reuters: Health - April 14, 2021 Category: Consumer Health News Source Type: news
Experts' medicine cabinet essentials: The shopping list to keep your family healthy
Whatever health problem you face -from cuts and stings to a thumping headache or even mild symptoms of Covid, such as fever - it is vital to have the correct, up-to-date products to hand. (Source: the Mail online | Health)
Source: the Mail online | Health - April 12, 2021 Category: Consumer Health News Source Type: news
Rwanda: How Wedding Entourage Ended Up at Stadium in Sting Operation
[New Times] The arrests sparked public outrage, especially on social media platforms. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - April 9, 2021 Category: African Health Source Type: news
