Polyphosphate attachment to lysine repeats is a non-covalent protein modification

Lysine polyphosphorylation was posited to be a covalent linkage of polyphosphate (polyP) to lysine sidechains within proteins. Neville et  al. find that this modification is non-covalent and sensitive to ionic strength and alkaline pH. Lysine residues alone drive polyP modification via electrostatic interaction with polyP.

Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Nolan Neville, Kirsten Lehotsky, Kody A. Klupt, Michael Downey, Zongchao Jia Tags: Matters Arising Source Type: research