SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

In conclusion, our study suggested that Sirt1 played a crucial role in regulating osteoblast metabolism to maintain bone homeostasis through its deacetylase activity on GOT1. These findings provided a novel insight into the potential targeting of osteoblast metabolism for the treatment of bone-related diseases.PMID:38700532 | DOI:10.1007/s00018-023-05043-9

Source: Cellular and Molecular Life Sciences : CMLS - May 3, 2024 Category: Cytology Authors: Xinxin Jin Xulei Sun Xiao Ma Zixuan Qin Xin Gao Xiaomin Kang Huixia Li Hongzhi Sun Source Type: research