Extended Tamoxifen May Double Endometrial Cancer Risk
(MedPage Today) -- But observed malignancies were detected early and carried low mortality risk (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - July 10, 2018 Category: Hematology Source Type: news

Breast-cancer drug taken by thousands of women doubles the risk of womb cancer
Researchers from St Vincent's Hospital Group, Dublin, found that taking tamoxifen for 10 years rather than five raises the risk of endometrial cancer from 1.5 per cent to 3.5 per cent. (Source: the Mail online | Health)
Source: the Mail online | Health - July 5, 2018 Category: Consumer Health News Source Type: news

Extended tamoxifen therapy may increase risk of endometrial cancer
(Wiley) There is clear evidence that extended adjuvant tamoxifen therapy for 10 years reduces local recurrence and improves breast cancer-free survival in women with oestrogen receptor-positive breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2018 Category: Cancer & Oncology Source Type: news

DNA Analysis in Early Breast Ca Reveals Markers of Recurrence
(MedPage Today) -- And PIK3CA mutations tied to letrozole benefit over tamoxifen (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - June 15, 2018 Category: Hematology Source Type: news

ASCO: Ovarian Suppression & #43; Tamoxifen Ups Breast CA Survival
TUESDAY, June 5, 2018 -- The addition of ovarian suppression to tamoxifen is associated with increased survival versus tamoxifen alone among premenopausal women with breast cancer, according to a study published online June 4 in the New England... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 5, 2018 Category: Pharmaceuticals Source Type: news

Thousands of breast cancer patients may be SPARED from chemotherapy
A landmark study in New York has found that a significant proportion of women with the disease need only a daily pill – such as tamoxifen – to stop their cancer returning after surgery. (Source: the Mail online | Health)
Source: the Mail online | Health - June 4, 2018 Category: Consumer Health News Source Type: news

5,000 British breast cancer patients per year could be spared chemotherapy by taking a daily pill
A landmark study in New York has found that a significant proportion of women with the disease need only a daily pill – such as tamoxifen – to stop their cancer returning after surgery. (Source: the Mail online | Health)
Source: the Mail online | Health - June 4, 2018 Category: Consumer Health News Source Type: news

Good News for Women With Breast Cancer: Many Don ’ t Need Chemo
Many women with early-stage forms of the disease can forego chemo, based on a test that measures the activity of genes involved in breast cancer recurrence. (Source: NYT Health)
Source: NYT Health - June 3, 2018 Category: Consumer Health News Authors: DENISE GRADY Tags: Breast Cancer Chemotherapy Tumors Hormones Tamoxifen (Drug) American Society of Clinical Oncology Genomic Health Inc Tests (Medical) Source Type: news

NICE guidance on tamoxifen prescribing has slow uptake
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 1, 2018 Category: Drugs & Pharmacology Source Type: news

Breast Cancer Risk and Tamoxifen Use
Only 1 in 7 Women at Risk for Breast Cancer Take Tamoxifen (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 30, 2018 Category: General Medicine Source Type: news

Only 1 in 7 Women at Risk for Breast Cancer Take Tamoxifen Only 1 in 7 Women at Risk for Breast Cancer Take Tamoxifen
A small study in the UK has found 6 of 7 women with a family history of breast cancer opted out of taking tamoxifen as a preventive measure.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 27, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

One in seven women taking pills which help prevent breast cancer
Only one in seven who are at high risk of breast cancer are taking Tamoxifen to reduce their chances of getting the disease, a study found. (Source: the Mail online | Health)
Source: the Mail online | Health - April 24, 2018 Category: Consumer Health News Source Type: news

Six in 7 women at high risk of breast cancer shun tamoxifen as a preventative measure
(Cancer Research UK) Six in seven women with a family history of breast cancer opt out of taking tamoxifen as a preventative measure, according to a study funded by Cancer Research UK and published in Breast Cancer Research and Treatment today. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 23, 2018 Category: Cancer & Oncology Source Type: news

Science Saturday: Z-Endoxifen emerges as potential breast cancer treatment
Summary Results of a phase I study in women showed that the treatment was safe and reduced tumors. Z-endoxifen, a potent derivative of the drug?tamoxifen, could be a new treatment for the most common form of breast cancer in women with metastatic disease. This finding was reported from a clinical trial conducted by researchers at [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 21, 2018 Category: Databases & Libraries Source Type: news

Tamoxifen and raloxifene slow down the progression of muscular dystrophy
(Elsevier) Steroids are currently the only available treatment to reduce the repetitive cycles of inflammation and disease progression associated with functional deterioration in patients with muscular dystrophy (MD). A study reported in The American Journal of Pathology showed that a new treatment approach using the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene significantly improved cardiac, respiratory, and skeletal muscle functions and increased bone density in both male and female mice with the same gene defects as a subset of patients with MD. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 20, 2018 Category: Biology Source Type: news

New international practice guidelines for tamoxifen treatment based on CYP2D6 genotype
(Mayo Clinic) An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium (CPIC) published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in Clinical Pharmacology and Therapeutics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 1, 2018 Category: Cancer & Oncology Source Type: news

Medical News Today: Can weight gain be caused by tamoxifen?
A look at the link between tamoxifen and weight gain. Included is detail on why weight gain can occur in breast cancer treatment, and other side effects. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 22, 2018 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Novartis Kisqali ® received FDA Breakthrough Therapy designation for initial endocrine-based treatment in premenopausal women with HR+/HER2- advanced breast cancer
Novartis today announced Kisqali® (ribociclib) received US Food and Drug Administration (FDA) Breakthrough Therapy designation for initial endocrine-based treatment of pre- or perimenopausal women with hormone-receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer in combination with tamoxifen or an aromatase inhibitor. (Source: World Pharma News)
Source: World Pharma News - January 3, 2018 Category: Pharmaceuticals Tags: Featured Novartis Business and Industry Source Type: news

JACQUIE BELTRAO on her tamoxifen living hell
Tamoixifen might be a lifesaver for breast cancer patients, but it's irritating side effects, such as late night hot flushes, are absolutely awful, writes Sky News' JACQUIE BELTRAO. (Source: the Mail online | Health)
Source: the Mail online | Health - December 17, 2017 Category: Consumer Health News Source Type: news

Breast cancer can return 20 years after first diagnosis
The disease can ‘lie dormant’ for years, reappearing long after patients get all-clear, say Oxford University researchers. Women may be told to continue drugs like tamoxifen for longer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 8, 2017 Category: Consumer Health News Source Type: news

Z-endoxifen shows promise as new treatment for common breast cancer type
(Mayo Clinic) ROCHESTER, Minn. - Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease. This finding was reported from a clinical trial conducted by researchers at Mayo Clinic and the National Cancer Institute, and published in the Journal of Clinical Oncology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 30, 2017 Category: International Medicine & Public Health Source Type: news

Z-endoxifen shows promise as new treatment for common breast cancer type
  ROCHESTER, Minn. ??Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease. This finding was reported from a clinical trial conducted by researchers at Mayo Clinic and the National Cancer Institute, and published in the Journal of [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - August 30, 2017 Category: Hospital Management Source Type: news

Adjuvant Endocrine Therapy in Postmenopausal Breast Cancer
This video highlights trials studying the long-term impact of adjuvant tamoxifen and aromatase inhibitors for the treatment of patients with postmenopausal breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - August 25, 2017 Category: Cancer & Oncology Authors: Prudence A. Francis, MD Tags: Videos Breast Cancer Source Type: news

Breast cancer wonder drug boosts IVF hopes
A British clinic is pioneering the use of tamoxifen - typically given to patients who have undergone breast cancer surgery - to help women aged over 40 who have a limited number of eggs. (Source: the Mail online | Health)
Source: the Mail online | Health - August 13, 2017 Category: Consumer Health News Source Type: news

Gene Score for Recurrence Risk in ER-Positive Breast Cancer Gene Score for Recurrence Risk in ER-Positive Breast Cancer
Can this gene recurrence score help determine which patients with ER-positive breast cancer are good candidates for radiotherapy after adjuvant chemotherapy plus tamoxifen?Journal of the National Cancer Institute (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 20, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

RCT: Menopause Symptoms Mistaken for Tamoxifen Side Effects RCT: Menopause Symptoms Mistaken for Tamoxifen Side Effects
Many women who use tamoxifen as a chemopreventive agent experience symptoms that are assumed to be drug related, but they may just be naturally occurring symptoms related to menopause.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 6, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Many Women Have Questions, Concerns About Tamoxifen
Study shows that normal symptoms of menopause are often attributed to tamoxifen (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 30, 2017 Category: Cancer & Oncology Tags: Family Medicine, Gynecology, Internal Medicine, Nursing, Oncology, Pharmacy, Journal, Source Type: news

Many Women Mistaken on'Side Effects' of Breast Cancer Drug
Study shows that normal symptoms of menopause are often blamed on tamoxifen Source: HealthDay Related MedlinePlus Pages: Breast Cancer, Drug Reactions, Menopause (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - June 30, 2017 Category: Consumer Health News Source Type: news

Many Women Mistaken on ‘ Side Effects ’ of Breast Cancer Drug
Study shows that normal symptoms of menopause are often blamed on tamoxifen (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 29, 2017 Category: Cancer & Oncology Tags: Gynecology, Nursing, Oncology, Pharmacy, News, Source Type: news

Breast cancer: Women confuse menopause symptoms to anti-breast cancer drug side effects
WOMEN at high risk of breast cancer are not taking the preventative drug tamoxifen because they are confusing symptoms of the menopause with side-effects, a new study found. (Source: Daily Express - Health)
Source: Daily Express - Health - June 29, 2017 Category: Consumer Health News Source Type: news

Many Women Mistaken on'Side Effects' of Breast Cancer Drug
THURSDAY, June 29, 2017 -- Many women at high risk for breast cancer do not take the drug tamoxifen to prevent the disease, often because they confuse naturally occurring symptoms with side effects from the drug. That's the finding of a new study of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 29, 2017 Category: General Medicine Source Type: news

Confusion over symptoms may be affecting whether women take tamoxifen for breast cancer
(Queen Mary University of London) Women who are at high risk of developing breast cancer may be failing to take the preventive anti-cancer drug tamoxifen because they are confusing naturally occurring symptoms with side effects from the medicine, according to a study of nearly 4,000 women led by Queen Mary University of London. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 29, 2017 Category: Cancer & Oncology Source Type: news

Systemic Therapy and Risk of Contralateral Breast Cancer Systemic Therapy and Risk of Contralateral Breast Cancer
After completing tamoxifen or chemotherapy, how long does risk reduction for contralateral breast cancer last?Breast Cancer Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 22, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Tamoxifen protects against obesity-related metabolic disorders
Tamoxifen is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer. Tamoxifen is also known to have metabolic effects. A new study reports that the drug also prevents obesity, fatty liver, and insulin resistance in female mice who were fed a high-fat diet and whose ovaries had been removed. The study was also able to pinpoint which estrogen receptors underlie these protective effects, opening up possibilities for new therapies to treat these conditions. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 11, 2017 Category: Science Source Type: news

Tamoxifen protects against obesity-related metabolic disorders
(Elsevier Health Sciences) Tamoxifen is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer. Tamoxifen is also known to have metabolic effects. A new study in The American Journal of Pathology reports that the drug also prevents obesity, fatty liver, and insulin resistance in female mice who were fed a high-fat diet and whose ovaries had been removed. The study was also able to pinpoint which estrogen receptors underlie these protective effects, opening up possibilities for new therapies to treat these conditions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 11, 2017 Category: International Medicine & Public Health Source Type: news

Prolonged Tamoxifen Surpasses Oophorectomy in Breast Cancer Prolonged Tamoxifen Surpasses Oophorectomy in Breast Cancer
For premenopausal women with estrogen receptor-positive breast cancer treated for 5 years with tamoxifen, lifetime outcomes are best with an extra 5 years of tamoxifen, a simulation model predicts.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 9, 2017 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Mangosteen: The Cancer-Fighting Superfruit
  If you're a woman with a family history of breast cancer, your doctor may recommend you start taking a toxic chemo drug like tamoxifen to lower your risk of developing the disease. Even if you have no signs or symptoms of cancer. Tamoxifen is what's known as a chemopreventive agent. That's a fancy phrase that means it's something that prevents cancer from forming. But its track record isn't all that impressive. Trials found that for every 1,000 women who take the drugs, only 21 to 35 cases of cancer would be prevented. And the side effects are downright terrifying. Bone pain, blood clots, increas...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Anti-Aging Source Type: news

Breast cancer drug dampens immune response, protecting light-sensing cells of the eye
The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice. The drug prevented immune cells from removing injured photoreceptors, the light-sensitive cells of the retina in the back of the eye. The study, recently reported in theJournal of Neuroscience, suggests tamoxifen might work for the treatment of age-related macular degeneration (AMD) and retinitis pigmentosa (RP), blinding diseases that lack good treatment options. (Source: News from NEI)
Source: News from NEI - March 13, 2017 Category: Opthalmology Authors: balintfyj Source Type: news

Breast cancer drug dampens immune response, protecting light-sensing cells of the eye
The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice. The drug prevented immune cells from removing injured photoreceptors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 13, 2017 Category: Science Source Type: news

Understanding GP attitudes to cancer preventing drugs
This report presents the results of a survey of GPs about their use of offering tamoxifen and aspirin to lower the risk of, or prevent, certain cancers. It found nearly half of GPs were unaware of the benefits of tamoxifen to prevent breast cancer. The report concludes more needs to be done to ensure GPs are given the support they need (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 28, 2017 Category: Consumer Health News Source Type: news

Understanding GP attitudes to cancer preventing drugs
A report from Cancer Research explores how much GPs know about two drugs that can reduce the risk of cancer – tamoxifen for women at high risk of breast cancer, and aspirin for people with Lynch Syndrome, a condition that increases the risk of several types of cancer. (Source: NHS Networks)
Source: NHS Networks - February 16, 2017 Category: UK Health Source Type: news

[Editors' Choice] Tamoxifen as an immunotherapy
Antiestrogen drugs may treat some estrogen receptor-negative tumors by limiting the proliferation and activity of suppressive immune cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

GPs 'failing to prescribe tamoxifen to prevent breast cancer'
Conclusion This large survey shows around half of GPs surveyed were unaware of the benefits of tamoxifen: namely, that the drug can reduce the risk of breast cancer in women with a family history of the condition. Only around a quarter of GPs surveyed were aware of the current UK guidelines. Researchers found GPs were more likely to feel comfortable carrying on a prescription initiated by hospital doctors, rather than being the one to take the decision to prescribe. This is perhaps unsurprising given that the drug is still not licensed for the primary prevention of cancer. NICE currently recommends prescribers need to ta...
Source: NHS News Feed - February 14, 2017 Category: Consumer Health News Tags: Cancer Medication Medical practice Source Type: news

Ignorant GPs deny patients drugs that ward off cancer
Two major UK studies have shown many GPs are unaware that prescribing certain patients daily pills - such as tamoxifen and aspirin - can slash their odds of developing certain tumours. (Source: the Mail online | Health)
Source: the Mail online | Health - February 14, 2017 Category: Consumer Health News Source Type: news

Work needed to boost GPs ’ knowledge of cancer drug
Only a quarter of GPs aware of NICE guideline on tamoxifen Related items fromOnMedica Tamoxifen linked to reduced contralateral breast cancer risk One in six breast cancer patients have symptom other than a lump Big data advances breast cancer research by ‘decades’ (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 13, 2017 Category: UK Health Source Type: news

Secondary care support can boost GP use of breast cancer prevention drug
Researchers have called for a joint primary and secondary care pathway to encourage prescribing of tamoxifen as a preventative treatment for women at increased risk of breast cancer. (Source: GP Online News)
Source: GP Online News - February 13, 2017 Category: Primary Care Tags: 12 Care of People with Cancer and Palliative Care Source Type: news

Older women less likely to be offered breast reconstruction after mastectomy
Guidelines state that surgeons should discuss breast reconstruction with all suitable patients Related items fromOnMedica Tamoxifen linked to reduced contralateral breast cancer risk Big data advances breast cancer research by ‘decades’ Breast conservation beats mastectomy for some patients Schoolboy youngest in UK to undergo mastectomy Study finds overuse of double mastectomy (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 8, 2017 Category: UK Health Source Type: news

Black Women Face Devastating Losses If Obamacare Is Repealed
Bianca Adams worked part-time jobs as a spa professional, sometimes juggling two or three at a time, for years. But none of them offered her insurance, which meant that the 47-year-old with diabetes often went to the emergency room for care. “I was one of those people that had to go to the emergency when my blood sugar got too high and I needed fluids,” Adams told The Huffington Post. “There was really no one managing my health at that point.” When her Medicaid coverage through the Affordable Care Act began in 2014, Adams, who has been disabled with severe knee problems for 25 years, under...
Source: Healthy Living - The Huffington Post - February 4, 2017 Category: Consumer Health News Source Type: news

How Soy Can Both Prevent Breast Cancer And Fuel Its Spread
To eat soy or not: That’s the question many U.S. women have been asking. Tofu, miso paste and other soybean-based foods are high-quality sources of protein that are low in calories and saturated fat. And studies have shown that they can help prevent cancer. Yet many doctors recommend that women who have, or are at risk of developing, a common form of breast cancer called estrogen-receptor-positive breast cancer avoid eating soybean-based foods because they contain compounds called isoflavones. Some studies suggest that isoflavones can mimic the hormone estrogen and encourage tumor growth. Now, in an animal study, res...
Source: Healthy Living - The Huffington Post - February 3, 2017 Category: Consumer Health News Source Type: news