Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (T... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 22, 2024 Category: Cytology Authors: Jeeyeon Lee, Eun-Ae Kim, Jieun Kang, Yee Soo Chae, Ho Yong Park, Byeongju Kang, Soo Jung Lee, In Hee Lee, Ji-Young Park, Nora Jee-young Park and Jin Hyang Jung Tags: Research Source Type: research
Toxicogenomics of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
In this study, the toxicogenomic effects of five cytostatics (tamoxifen, methotrexate, capecitabine, cyclophosphamide, and ifosfamide) on fathead minnow (Pimephales promelas) larvae were evaluated. Post-fertilization eggs were exposed to increasing concentrations of the drugs for six days. The expression levels of two genetic biomarkers for toxicity and four thyroid hormone-related gene pathways were measured. Interestingly, the results showed that all concentrations of the five cytostatics affect the transcription levels of both toxicity biomarker genes. Additionally, the thyroid hormone-related genes had different expres...
Source: Bulletin of Environmental Contamination and Toxicology - April 21, 2024 Category: Environmental Health Authors: D C Casta ñeda-Cortés M Lefebvre-Raine G Triffault-Bouchet V S Langlois Source Type: research
Toxicogenomics of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
In this study, the toxicogenomic effects of five cytostatics (tamoxifen, methotrexate, capecitabine, cyclophosphamide, and ifosfamide) on fathead minnow (Pimephales promelas) larvae were evaluated. Post-fertilization eggs were exposed to increasing concentrations of the drugs for six days. The expression levels of two genetic biomarkers for toxicity and four thyroid hormone-related gene pathways were measured. Interestingly, the results showed that all concentrations of the five cytostatics affect the transcription levels of both toxicity biomarker genes. Additionally, the thyroid hormone-related genes had different expres...
Source: Bulletin of Environmental Contamination and Toxicology - April 21, 2024 Category: Environmental Health Authors: D C Casta ñeda-Cortés M Lefebvre-Raine G Triffault-Bouchet V S Langlois Source Type: research
Stasimon/Tmem41b is required for cell proliferation and adult mouse survival
This study provides new insights into the essential requirement of Stasimon/Tmem41b for cellular and organismal fitness and expands the experimental toolkit to investigate its functions in the mammalian system.PMID:38640735 | DOI:10.1016/j.bbrc.2024.149923 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 19, 2024 Category: Biochemistry Authors: Maria J Carlini Meaghan Van Alstyne Hua Yang Shubhi Yadav Neil A Shneider Livio Pellizzoni Source Type: research
Diagnostic Conundrum of a Sertoli Cell Tumor in a 2-Year-Old Girl with Peripheral Precocious Puberty and a Cafe-Au-Lait Macule: A Case Report
CONCLUSION: The findings in our patient were strikingly similar to those encountered in MAS. To our knowledge, our patient is the youngest ever reported to present with precocious puberty due to a Sertoli cell tumor in the setting of PJS.PMID:38626741 | DOI:10.1159/000538945 (Source: Cell Research)
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Lauren A Ray Deborah F Billmire Michael J Ferguson Erica A Eugster Source Type: research
Community cohesion looseness in gene networks reveals individualized drug targets and resistance
Brief Bioinform. 2024 Mar 27;25(3):bbae175. doi: 10.1093/bib/bbae175.ABSTRACTCommunity cohesion plays a critical role in the determination of an individual's health in social science. Intriguingly, a community structure of gene networks indicates that the concept of community cohesion could be applied between the genes as well to overcome the limitations of single gene-based biomarkers for precision oncology. Here, we develop community cohesion scores which precisely quantify the community ability to retain the interactions between the genes and their cellular functions in each individualized gene network. Using breast can...
Source: Briefings in Bioinformatics - April 15, 2024 Category: Bioinformatics Authors: Seunghyun Wang Doheon Lee Source Type: research
Long-Term Oral Tamoxifen Administration Decreases Brain-Derived Neurotrophic Factor in the Hippocampus of Female Long-Evans Rats
Cancers (Basel). 2024 Mar 31;16(7):1373. doi: 10.3390/cancers16071373.ABSTRACTTamoxifen, a selective estrogen receptor modulator (SERM), is commonly used as an adjuvant drug therapy for estrogen-receptor-positive breast cancers. Though effective at reducing the rate of cancer recurrence, patients often report unwanted cognitive and affective side effects. Despite this, the impacts of chronic tamoxifen exposure on the brain are poorly understood, and rodent models of tamoxifen exposure do not replicate the chronic oral administration seen in patients. We, therefore, used long-term ad lib consumption of medicated food pellet...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Laura E Been Amanda R Halliday Sarah M Blossom Elena M Bien Anya G Bernhard Grayson E Roth Karina I Domenech Rosario Karlie B Pollock Petra E Abramenko Leily M Behbehani Gabriel J Pascal Mary Ellen Kelly Source Type: research
The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials
CONCLUSION: Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.PMID:38608792 | DOI:10.1016/j.exger.2024.112431 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: XingDa Li XueJiao Hou Benjamin Hern ández-Wolters Kousalya Prabahar Hamed Kord-Varkaneh Bo Mei Source Type: research
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
CONCLUSION: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.PMID:38603833 | DOI:10.1016/j.bbrc.2024.149888 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Shuai Zhang Wenjun Hao Dongying Chen Siwen Chen Zihao Li Fangling Zhong Haitao Wang Jianru Wang Zhaomin Zheng Zhongping Zhan Guo Dai Hui Liu Source Type: research
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
CONCLUSION: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.PMID:38603833 | DOI:10.1016/j.bbrc.2024.149888 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Shuai Zhang Wenjun Hao Dongying Chen Siwen Chen Zihao Li Fangling Zhong Haitao Wang Jianru Wang Zhaomin Zheng Zhongping Zhan Guo Dai Hui Liu Source Type: research
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
CONCLUSION: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.PMID:38603833 | DOI:10.1016/j.bbrc.2024.149888 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Shuai Zhang Wenjun Hao Dongying Chen Siwen Chen Zihao Li Fangling Zhong Haitao Wang Jianru Wang Zhaomin Zheng Zhongping Zhan Guo Dai Hui Liu Source Type: research
Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction
CONCLUSIONS: Our data show that GPRC5C regulates Ang II-dependent vascular contraction by facilitating AT1 receptor-ligand binding and signaling.PMID:38597112 | DOI:10.1161/CIRCRESAHA.123.323752 (Source: Cell Research)
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Tianpeng Wang Jingchen Shao Shamit Kumar Mohammad Wessam Alnouri Jorge Carvalho Stefan G ünther Cornelius Krasel Kate T Murphy Moritz B ünemann Stefan Offermanns Nina Wettschureck Source Type: research
Radiological, pathological and surgical outcomes after neoadjuvant endocrine treatment in patients with ER-positive/HER2-negative breast cancer with a clinical high risk and a low-risk 70-gene signature
CONCLUSION: The study showed that a subgroup of patients with a clinical high risk and a genomic low risk ER+/HER2-breast cancer benefits from NET resulting in BCS instead of a mastectomy. Additionally, NET may enable de-escalation in axillary treatment.PMID:38599047 | DOI:10.1016/j.breast.2024.103726 (Source: Breast)
Source: Breast - April 10, 2024 Category: Cancer & Oncology Authors: Josefien P van Olmen Chaja F Jacobs Sanne A L Bartels Claudette E Loo Joyce Sanders Marie-Jeanne T F D Vrancken Peeters Caroline A Drukker Frederieke H van Duijnhoven Marleen Kok Source Type: research
Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction
CONCLUSIONS: Our data show that GPRC5C regulates Ang II-dependent vascular contraction by facilitating AT1 receptor-ligand binding and signaling.PMID:38597112 | DOI:10.1161/CIRCRESAHA.123.323752 (Source: Circulation Research)
Source: Circulation Research - April 10, 2024 Category: Cardiology Authors: Tianpeng Wang Jingchen Shao Shamit Kumar Mohammad Wessam Alnouri Jorge Carvalho Stefan G ünther Cornelius Krasel Kate T Murphy Moritz B ünemann Stefan Offermanns Nina Wettschureck Source Type: research
Network-based identification of key proteins and repositioning of drugs for non-small cell lung cancer
CONCLUSION: Hence, there is a possibility of repurposing these drugs for the treatment of non-small-cell lung cancer.PMID:38600056 | DOI:10.1002/cnr2.2031 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Oluwatosin Maryam Adeyemo Zainab Ashimiyu-Abdusalam Mary Adewunmi Temitope Ayanfunke Ayano Muhammad Sohaib Reem Abdel-Salam Source Type: research
