Retraction Note: Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer
Oncogene, Published online: 23 February 2024; doi:10.1038/s41388-024-02983-9Retraction Note: Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer (Source: Oncogene)
Source: Oncogene - February 23, 2024 Category: Cancer & Oncology Authors: X. Q. Zheng J. P. Guo H. Yang M. Kanai L. L. He Y. Y. Li J. M. Koomen S. Minton M. Gao X. B. Ren D. Coppola J. Q. Cheng Source Type: research
The anticancer activity of bile acids in drug discovery and development
Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system. They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. In additional, BAs have demonstrated the ability to attenuate disease progression such as diabetes, metabolic disorders, heart disease, and respiratory ailments. Intriguingly, recent research has offered exciting evidence to unveil their potential antitumor properties against various cancer cell types incl...
Source: Frontiers in Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Source Type: research
Gynecologic Care of Black Breast Cancer Survivors
AbstractPurpose of ReviewBlack patients suffer from breast cancer-related racial health disparities, which could have implications on their gynecologic care. This review explores considerations in the gynecologic care of Black breast cancer survivors.Recent FindingsBlack people have a higher risk of leiomyoma and endometrial cancer, which could confound bleeding patterns such as in the setting of tamoxifen use. As Black people are more likely to have early-onset breast cancer, this may have implications on long-term bone and heart health. Black patients may be more likely to have menopausal symptoms at baseline and as a re...
Source: Current Breast Cancer Reports - February 19, 2024 Category: Cancer & Oncology Source Type: research
GSE225495 Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by, kidney macrophages
Conclusion: Chronic dietary protein load-induced renal hypertrophy and accelerated cyst growth in Pkd1KO mice is dependent on both infiltrating and resident M Ф recruitment and subsequent inflammatory response. Early cyst expansion by HP diet, however, is relient on increased delivery of glutamine to kidney epithelial cells, driving downstream metabolic changes prior to inflammatory provocation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER− cells via endoplasmic reticulum stress-induced apoptosis
Cell Death & Disease, Published online: 15 February 2024; doi:10.1038/s41419-024-06539-3A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER− cells via endoplasmic reticulum stress-induced apoptosis (Source: Cell death and disease)
Source: Cell death and disease - February 15, 2024 Category: Internal Medicine Authors: Tinglin Yang Wenhui Li Jun Zhou Ming Xu Ziwei Huang Jie Ming Tao Huang Source Type: research
The risk factors for premalignant and malignant endometrial polyps in premenopausal and postmenopausal women and trends over the past decade: A retrospective study in a single center, South Korea
CONCLUSIONS: Menopause, abnormal uterine bleeding, obesity, multiple polyps, and nulliparity increase the risk of premalignancy and malignancy in endometrial polyps. The prevalence of premalignant and malignant polyps has been increasing over the past decade. The risk factors that have contributed to this trend were obesity, nulliparity, and multiple polyps.PMID:38354603 | DOI:10.1016/j.ejogrb.2024.01.033 (Source: Reproductive Biology)
Source: Reproductive Biology - February 14, 2024 Category: Reproduction Medicine Authors: Shina Jang Sung Ook Hwang Source Type: research
Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice
In this study, we investigated the function of UBIAD1 in osteogenesis using a tamoxifen-dependent UBIAD1-deficient mouse model. When UBIAD1 deficiency was induced from the first week of life, the femur was significantly shortened, and bone mineral density (BMD) was reduced. In addition, the expression of bone and chondrocyte matrix proteins and chondrocyte differentiation factors was significantly decreased. In primary cultured chondrocytes, chondrocyte differentiation was significantly reduced by UBIAD1 deficiency. These results suggest that UBIAD1 is an important factor for the regulation of chondrocyte proliferation and...
Source: Biochemical and Biophysical Research communications - February 9, 2024 Category: Biochemistry Authors: Shunsuke Hirashima Yukino Kiyooka Shinichiro Kaetsu Kimie Nakagawa Source Type: research
GSE253151 scRNA-seq for stromal Lkb1 deficiency-induced gastrointestinal polyps
Contributors : Zhaohua Cai ; Yangjing Jiang ; Min Liang ; Yijie Huang ; Ben HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNumerous studies have showed that mesenchymal-specific Lkb1 is sufficient for the development of PJS-like polyps in mice. However, the cellular origin and component of these Lkb1-associated polyps and underlying mechanisms remain elusive. In this present study, we generated tamoxifen-inducible Lkb1flox/flox;Myh11-Cre/ERT2 mice and performed scRNA-seq to investigate the cellular complexity of gastrointestinal polyps associated with PJS. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 9, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Effect of telehealth interventions on adherence to endocrine therapy among patients with breast cancer: a systematic review and meta-analysis
ConclusionTelehealth interventions may facilitate adherence to endocrine therapy among patients with breast cancer. Further research should adopt a theory-based design and explore the longer-term effects. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - February 9, 2024 Category: Cancer & Oncology Source Type: research
Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment
This study, therefore, evaluated effects of tamoxifen on development of analgesic tolerance and dependence, and brain glutamate and glutamine levels in chronic morphine administration. Mice implanted with placebo or morphine pellets were injected with tamoxifen (0.6-2mg/kg) or vehicle twice daily for 3 days. Nociceptive response was evaluated in the hot plate and tail immersion tests, 4, 48 and 72h post-implant, and following a challenge dose of morphine (10mg/kg). Withdrawal signs were determined after naloxone (1mg/kg) administration. Morphine increased nociceptive threshold which declined over time. At 72h, acute morphi...
Source: Behavioural Brain Research - February 8, 2024 Category: Neurology Authors: Asiye Nurten M Zafer G ören Nurdan Tekin Mert Ka şkal Nurhan Enginar Source Type: research
Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment
This study, therefore, evaluated effects of tamoxifen on development of analgesic tolerance and dependence, and brain glutamate and glutamine levels in chronic morphine administration. Mice implanted with placebo or morphine pellets were injected with tamoxifen (0.6-2mg/kg) or vehicle twice daily for 3 days. Nociceptive response was evaluated in the hot plate and tail immersion tests, 4, 48 and 72h post-implant, and following a challenge dose of morphine (10mg/kg). Withdrawal signs were determined after naloxone (1mg/kg) administration. Morphine increased nociceptive threshold which declined over time. At 72h, acute morphi...
Source: Brain Research - February 8, 2024 Category: Neurology Authors: Asiye Nurten M Zafer G ören Nurdan Tekin Mert Ka şkal Nurhan Enginar Source Type: research
The impact of hormones in autoimmune cutaneous diseases
CONCLUSION: Pregnancy, menopause, contraceptive use, hormone replacement therapy, and breast cancer treatment drugs result in substantial shifts in hormone levels. Additionally, hormone levels are altered by aromatase inhibitors and anti-estrogen medications. These fluctuations can modulate mechanisms influencing autoimmune skin abnormalities.PMID:38317519 | DOI:10.1080/09546634.2024.2312241 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 6, 2024 Category: Dermatology Authors: Lais Lopes Almeida Gomes Adrienne J Werth Preethi Thomas Victoria P Werth Source Type: research
Clemastine/Tamoxifen Hybrids as Easily Accessible Antileishmanial Drug Leads
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Victor de Sousa Agostino, Michaela L Buerdsell, Silvia R B Uliana, Paul W Denny, Adriano C Coelho, P. G. Steel Repurposing of drugs is an attractive strategy to accelerate drug discovery. In this context, tamoxifen, a selective oestrogen receptor modulator (SERM) and known anti-breast cancer drug, has been identified as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 5, 2024 Category: Molecular Biology Authors: Victor de Sousa Agostino Source Type: research
Cancers, Vol. 16, Pages 678: Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer
Conclusion: Our study revealed the HER2-E subtype conversion during LNM in BC. Macrophages were the crucial cell type in TME, inducing the downregulation of HR and upregulation of HER2, probably via MNX1. Targeting macrophages or MNX1 may provide new avenues for endocrine therapy and targeted treatment of BC patients with LNM. (Source: Cancers)
Source: Cancers - February 5, 2024 Category: Cancer & Oncology Authors: Xiaoyan Zhang Fengyu Yang Zhijian Huang Xiaojun Liu Gan Xia Jieye Huang Yang Yang Junchen Li Jin Huang Yuxin Liu Ti Zhou Weiwei Qi Guoquan Gao Xia Yang Tags: Article Source Type: research
The landscape of very important pharmacogenes variants and potential clinical relevance in the Chinese Jingpo population: a comparative study with worldwide populations
ConclusionOur study unveils distinct pharmacogenomic variants in the Jingpo population and discovers their association with the metabolic efficiency of NSAIDs, montelukast, and tamoxifen. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - February 1, 2024 Category: Cancer & Oncology Source Type: research
