Ameliorating Effects of Histamine H3 Receptor Antagonist E177 on Acute Pentylenetetrazole-Induced Memory Impairments in Rats
Behav Brain Res. 2021 Feb 21:113193. doi: 10.1016/j.bbr.2021.113193. Online ahead of print.ABSTRACTHistamine H3 receptors (H3Rs) are involved in several neuropsychiatric diseases including epilepsy. Therefore, the effects of H3R antagonist E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) were evaluated on acute pentylenetetrazole (PTZ)-induced memory impairments, oxidative stress levels (glutathione (GSH), malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD)), various brain neurotransmitters (histamine (HA), acetylcholine (ACh), γ-aminobutyric acid (GABA)), and glutamate (Glu), acetylcholine esterase (A...
Source: Behavioural Brain Research - February 24, 2021 Category: Neurology Authors: Alaa Alachkar Mohamed Lotfy Ernest Adeghate Dorota Łażewska Katarzyna Kie ć-Kononowicz Bassem Sadek Source Type: research

Androgenic morality? Associations of sex, oral contraceptive use and basal testosterone levels with moral decision making
Behav Brain Res. 2021 Feb 20:113196. doi: 10.1016/j.bbr.2021.113196. Online ahead of print.ABSTRACTAside from cultural, psychological, or situational factors, differences in moral judgements might also be influenced by biological variables. Since previous studies have reported stronger utilitarian tendencies in men, the relationship between testosterone and moral judgments has gained interest. Utilitarian judgements focus on the consequences of an action in terms of a cost-benefit analysis while deontological judgements are based on rules that are independent of an action's outcome or of situational features. We investigat...
Source: Behavioural Brain Research - February 23, 2021 Category: Neurology Authors: Diana Armbruster Clemens Kirschbaum Alexander Strobel Source Type: research

Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice
CONCLUSION: Combining task-based rehabilitative training with PTEN inhibition further promotes axon regeneration, synaptic plasticity and reorganization of the neural network, with significant improvement in forelimb skilled motor function after cervical spinal cord injury. Our study provides new therapeutic insights for spinal cord injury management in the future.PMID:33621609 | DOI:10.1016/j.bbr.2021.113197 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 23, 2021 Category: Neurology Authors: Lu Pan Botao Tan Weiwei Tang Meiling Luo Yuan Liu Lehua Yu Yin Ying Source Type: research

Androgenic morality? Associations of sex, oral contraceptive use and basal testosterone levels with moral decision making
Behav Brain Res. 2021 Feb 20:113196. doi: 10.1016/j.bbr.2021.113196. Online ahead of print.ABSTRACTAside from cultural, psychological, or situational factors, differences in moral judgements might also be influenced by biological variables. Since previous studies have reported stronger utilitarian tendencies in men, the relationship between testosterone and moral judgments has gained interest. Utilitarian judgements focus on the consequences of an action in terms of a cost-benefit analysis while deontological judgements are based on rules that are independent of an action's outcome or of situational features. We investigat...
Source: Behavioural Brain Research - February 23, 2021 Category: Neurology Authors: Diana Armbruster Clemens Kirschbaum Alexander Strobel Source Type: research

Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice
CONCLUSION: Combining task-based rehabilitative training with PTEN inhibition further promotes axon regeneration, synaptic plasticity and reorganization of the neural network, with significant improvement in forelimb skilled motor function after cervical spinal cord injury. Our study provides new therapeutic insights for spinal cord injury management in the future.PMID:33621609 | DOI:10.1016/j.bbr.2021.113197 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 23, 2021 Category: Neurology Authors: Lu Pan Botao Tan Weiwei Tang Meiling Luo Yuan Liu Lehua Yu Yin Ying Source Type: research

Beneficial effects of combined administration of fluoxetine and mitochondria-targeted antioxidant at in behavioural and molecular studies in mice model of depression
Behav Brain Res. 2021 Feb 19:113185. doi: 10.1016/j.bbr.2021.113185. Online ahead of print.ABSTRACTChronic or recurrent stress is associated with reactive oxygen species (ROS) overproduction and can lead to oxidative damage, which plays important roles in neurodegenerative diseases. Mito - TEMPO is an antioxidant targeted at mitochondria. The aim of the presented study was to assess antidepressant and antioxidant efficacy of Mito - TEMPO administered alone or with fluoxetine in mice exposed to chronic stress. The evaluation of the antidepressant-like activity was based on forced swimming test (FST) and tail suspension test...
Source: Behavioural Brain Research - February 22, 2021 Category: Neurology Authors: Mariola Herbet Izabela Szume łda Iwona Pi ątkowska-Chmiel Monika Gawro ńska-Grzywacz Jaros ław Dudka Source Type: research

Neuropeptide Y and glutamatergic mechanisms in the amygdala and ventral hippocampus differentially mediate impaired social behavior in diabetic mice
Behav Brain Res. 2021 Feb 19:113195. doi: 10.1016/j.bbr.2021.113195. Online ahead of print.ABSTRACTThough patients with diabetes mellitus are reported to show deficits in social interaction, the mechanisms of these impairments are unclear. The present study investigated the role of AMPA and neuropeptide Y (NPY) receptors in the ventral hippocampus (vHC) and basolateral amygdala (BLA) in the social behavior of diabetic mice. In the three-chamber test, streptozotocin (STZ)-induced diabetic mice showed impairment in social novelty preference, but not in sociability. Injection of the AMPA receptor antagonist NBQX into vHC or B...
Source: Behavioural Brain Research - February 22, 2021 Category: Neurology Authors: Daiki Ueda Naomi Yonemochi Tomohiro Kamata Junzo Kamei John L Waddington Hiroko Ikeda Source Type: research

Behavioral characterization of a novel Cisd2 mutant mouse
Behav Brain Res. 2021 Feb 18:113187. doi: 10.1016/j.bbr.2021.113187. Online ahead of print.ABSTRACTWolfram syndrome (WFS) is a rare autosomal recessive disorder characterized by diabetes mellitus and insipidus, progressive optic atrophy and sensorineural deafness. An increased incidence of psychiatric disorders has also been reported in WFS patients. There are two subtypes of WFS. Type 1 (WFS1) is caused by mutations in the WFS1 gene and type 2 (WFS2) results from mutations in the CISD2 gene. Existing Wfs1 knockout mice exhibit many WFS1 cardinal symptoms including diabetic nephropathy, metabolic disruptions and optic atro...
Source: Behavioural Brain Research - February 21, 2021 Category: Neurology Authors: Christiann H Gaines Angela E Snyder Robin B Ervin Joseph Farrington Kenneth Walsh Sarah A Schoenrock Lisa M Tarantino Source Type: research

The acute effects of multiple doses of methamphetamine on locomotor activity and anxiety-like behavior in adolescent and adult mice
Behav Brain Res. 2021 Feb 16:113186. doi: 10.1016/j.bbr.2021.113186. Online ahead of print.ABSTRACTMethamphetamine (MA) is a highly addictive psychomotor stimulant drug. Research has shown that the acute effects of MA can be modulated by age, although previous findings from our lab do not find age differences in the effects of MA. Relatively little research has examined the effects of adolescent MA exposure; thus, it is important to understand how MA affects adolescent behavior and brain function compared to adults. In order to better understand the age differences in the effects of acute MA exposure, this research examine...
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Hayley A Ortman Mikayla Newby Jonathan Acevedo Jessica A Siegel Source Type: research

Comparison of memory, affective behavior, and neuropathology in APP < sup > NLGF < /sup > knock-in mice to 5xFAD and APP/PS1 mice
In this study, we compared memory and affective behavior in APPNLGF mice, an APP knock-in model, to two widely used mouse models of Alzheimer's disease, 5xFAD and APP/PS1 mice, at 10 months of age. We found that, despite similar deficits in working memory, object recognition, and social recognition memory, APPNLGF and 5xFAD mice but not APP/PS1 mice show compelling anxiety- and depressive-like behavior, and exhibited a marked impairment of social interaction. We quantified corticolimbic Aβ plaques, which were lowest in APPNLGF, intermediate in APP/PS1, and highest in 5xFAD mice. Interestingly, analysis of plaque size ...
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Andrea Locci Hector Orellana Guadalupe Rodriguez Meredith Gottliebson Bryan McClarty Sky Dominguez Rachel Keszycki Hongxin Dong Source Type: research

A Novel Gabapentin Analogue Assuages Neuropathic Pain Response in Chronic Sciatic Nerve Constriction Model in Rats
Behav Brain Res. 2021 Feb 16:113190. doi: 10.1016/j.bbr.2021.113190. Online ahead of print.NO ABSTRACTPMID:33607164 | DOI:10.1016/j.bbr.2021.113190 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Nisar Ahmad Fazal Subhan Nazar Ul Islam Muhammad Shahid Naseem Ullah Rahim Ullah Shehla Akbar Muhammad Usman Amin Muhammad Khurram Ihsan Ullah Robert D E Sewell Source Type: research

Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia
Behav Brain Res. 2021 Feb 16:113189. doi: 10.1016/j.bbr.2021.113189. Online ahead of print.ABSTRACTThe endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G protein-coupled receptors, NTS1 and NTS2. Whereas both NT receptors mediate the analgesic effects of NT, NTS1 activation also produces hypotension and hypothermia, which may represent obstacles for the development of new pain medications. In the present study, we implemented various chemical strategies to improve the metabolic stability of the biolo...
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: M élanie Vivancos Roberto Fanelli Élie Besserer-Offroy Sabrina Beaulieu Magali Chartier Martin Resua-Rojas Christine E Mona Santo Previti Emmanuelle R émond Jean-Michel Longpr é Florine Cavelier Philippe Sarret Source Type: research

Injection of galanin into the dorsal hippocampus impairs emotional memory independent of 5-HT < sub > 1A < /sub > receptor activation
Behav Brain Res. 2021 Feb 16:113178. doi: 10.1016/j.bbr.2021.113178. Online ahead of print.ABSTRACTThere is evidence that interaction between the neuropeptide galanin and the 5-HT1A receptor represents an integrative mechanism in the regulation of serotonergic neurotransmission. Thus, in rats intracerebroventricular (i.c.v.) galanin did not impair retention in the passive avoidance (PA) test 24 h after training, but attenuated the retention deficit caused by subcutaneous (s.c.) administration of the 5-HT1A receptor agonist 8-OH-DPAT. This impairment has been linked to postsynaptic 5-HT1A receptor activation. To confirm the...
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Oliver Stiedl Eugenia Kuteeva Tomas H ökfelt Sven Ove Ögren Source Type: research

Contribution of the hippocampus to performance on the Traveling Salesperson Problem in rats
Behav Brain Res. 2021 Feb 16:113177. doi: 10.1016/j.bbr.2021.113177. Online ahead of print.ABSTRACTThe Traveling Salesman Problem (TSP) is an optimization problem in which the subject attempts to find the shortest possible route that passes through a set of fixed locations exactly once. The TSP is used in cognitive and behavioral research to study problem solving and spatial navigation. While the TSP has been studied in some depth from this perspective, the biological mechanisms underlying the behavior have not yet been explored. The hippocampus is a structure in the brain that is known to be involved in tasks that require...
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Jena B Hales Elizabeth A Petty Gequasha Collins Rachel Blaser Source Type: research

Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid
In conclusion, elevation of KA levels contributes to depression-like behaviors in KMO KO mice by α7nAChR antagonism. The ameliorating effects of nicotine and galantamine on depression-like behaviors in KMO KO mice are associated with the activation of α7nAChR.PMID:33607168 | DOI:10.1016/j.bbr.2021.113191 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Yuko Mori Akihiro Mouri Kazuo Kunisawa Mami Hirakawa Hisayoshi Kubota Aika Kosuge Moe Niijima Masaya Hasegawa Hitomi Kurahashi Reiko Murakami Masato Hoshi Takashi Nakano Suwako Fujigaki Hidetsugu Fujigaki Yasuko Yamamoto Toshitaka Nabeshima Kuniaki Saito Source Type: research

Prefrontal NMDA-receptor antagonism disrupts encoding or consolidation but not retrieval of incidental context learning
Behav Brain Res. 2021 Feb 14:113175. doi: 10.1016/j.bbr.2021.113175. Online ahead of print.ABSTRACTThe Context Preexposure Facilitation Effect (CPFE) is a variant of contextual fear conditioning in which learning about the context, acquiring a context-shock association, and retrieval of this association occur separately across three phases (context preexposure, immediate-shock training, and retention). We have shown that prefrontal inactivation or muscarinic-receptor antagonism prior to any phase disrupts retention test freezing during the CPFE in adolescent rats (Heroux et al., 2017; Robinson-Drummer et al., 2017). Furthe...
Source: Behavioural Brain Research - February 17, 2021 Category: Neurology Authors: Nicholas A Heroux Colin J Horgan Mark E Stanton Source Type: research

Prediction errors and valence: From single units to multidimensional encoding in the amygdala
Behav Brain Res. 2021 Feb 14;404:113176. doi: 10.1016/j.bbr.2021.113176. Online ahead of print.ABSTRACTThe amygdala-one of the primary structures of the limbic system-is comprised of interconnected nuclei situated within the temporal lobe. It has a well-established role in the modulation of negative affective states, as well as in fear processing. However, its vast projections with diverse brain regions-ranging from the cortex to the brainstem-are suggestive of its more complex involvement in affective or motivational aspects of cognitive processing. The amygdala can play an invaluable role in context-dependent associative...
Source: Behavioural Brain Research - February 17, 2021 Category: Neurology Authors: Adam T Brockett Daniela V ázquez Matthew R Roesch Source Type: research

The causal involvement of the right supramarginal gyrus in the subjective experience of time: A hf-tRNS study
Behav Brain Res. 2021 Feb 13;404:113157. doi: 10.1016/j.bbr.2021.113157. Online ahead of print.ABSTRACTNeural populations in the supramarginal gyrus (SMG) of the right hemisphere have been shown to be involved in processing the subjective experience of time, particularly because of their selectivity to specific temporal durations. To directly investigate this relationship, we applied high-frequency transcranial Random Noise Stimulation (hf-tRNS) on the right SMG during a duration judgment task: 24 participants were required to judge the duration of a test visual stimulus (350, 450, 550, 650 ms) as shorter or longer than th...
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Giulia Prete Chiara Lucaf ò Gianluca Malatesta Luca Tommasi Source Type: research

The acute effects of multiple doses of methamphetamine on locomotor activity and anxiety-like behavior in adolescent and adult mice.
Abstract Methamphetamine (MA) is a highly addictive psychomotor stimulant drug. Research has shown that the acute effects of MA can be modulated by age, although previous findings from our lab do not find age differences in the effects of MA. Relatively little research has examined the effects of adolescent MA exposure; thus, it is important to understand how MA affects adolescent behavior and brain function compared to adults. In order to better understand the age differences in the effects of acute MA exposure, this research examined the effects of MA exposure on locomotor and anxiety-like behavior and plasma co...
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Ortman HA, Newby M, Acevedo J, Siegel JA Tags: Behav Brain Res Source Type: research

Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice.
In this study, we compared memory and affective behavior in APPNLGF mice, an APP knock-in model, to two widely used mouse models of Alzheimer's disease, 5xFAD and APP/PS1 mice, at 10 months of age. We found that, despite similar deficits in working memory, object recognition, and social recognition memory, APPNLGF and 5xFAD mice but not APP/PS1 mice show compelling anxiety- and depressive-like behavior, and exhibited a marked impairment of social interaction. We quantified corticolimbic Aβ plaques, which were lowest in APPNLGF, intermediate in APP/PS1, and highest in 5xFAD mice. Interestingly, analysis of plaque size ...
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Locci A, Orellana H, Rodriguez G, Gottliebson M, McClarty B, Dominguez S, Keszycki R, Dong H Tags: Behav Brain Res Source Type: research

A Novel Gabapentin Analogue Assuages Neuropathic Pain Response in Chronic Sciatic Nerve Constriction Model in Rats.
PMID: 33607164 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Ahmad N, Subhan F, Islam NU, Shahid M, Ullah N, Ullah R, Akbar S, Amin MU, Khurram M, Ullah I, Sewell RDE Tags: Behav Brain Res Source Type: research

Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia.
elier F, Sarret P Abstract The endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G protein-coupled receptors, NTS1 and NTS2. Whereas both NT receptors mediate the analgesic effects of NT, NTS1 activation also produces hypotension and hypothermia, which may represent obstacles for the development of new pain medications. In the present study, we implemented various chemical strategies to improve the metabolic stability of the biologically active fragment NT(8-13) and assessed their NTS1/NTS2 r...
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Vivancos M, Fanelli R, Besserer-Offroy É, Beaulieu S, Chartier M, Resua-Rojas M, Mona CE, Previti S, Rémond E, Longpré JM, Cavelier F, Sarret P Tags: Behav Brain Res Source Type: research

Injection of galanin into the dorsal hippocampus impairs emotional memory independent of 5-HT1A receptor activation.
gren SO Abstract There is evidence that interaction between the neuropeptide galanin and the 5-HT1A receptor represents an integrative mechanism in the regulation of serotonergic neurotransmission. Thus, in rats intracerebroventricular (i.c.v.) galanin did not impair retention in the passive avoidance (PA) test 24 h after training, but attenuated the retention deficit caused by subcutaneous (s.c.) administration of the 5-HT1A receptor agonist 8-OH-DPAT. This impairment has been linked to postsynaptic 5-HT1A receptor activation. To confirm these results in mice, galanin was infused i.c.v. (1 nmol/mous...
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Stiedl O, Kuteeva E, Hökfelt T, Ögren SO Tags: Behav Brain Res Source Type: research

Contribution of the hippocampus to performance on the Traveling Salesperson Problem in rats.
Abstract The Traveling Salesman Problem (TSP) is an optimization problem in which the subject attempts to find the shortest possible route that passes through a set of fixed locations exactly once. The TSP is used in cognitive and behavioral research to study problem solving and spatial navigation. While the TSP has been studied in some depth from this perspective, the biological mechanisms underlying the behavior have not yet been explored. The hippocampus is a structure in the brain that is known to be involved in tasks that require spatial memory. Because the TSP requires spatial problem solving, we designed th...
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Hales JB, Petty EA, Collins G, Blaser R Tags: Behav Brain Res Source Type: research

Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.
In conclusion, elevation of KA levels contributes to depression-like behaviors in KMO KO mice by α7nAChR antagonism. The ameliorating effects of nicotine and galantamine on depression-like behaviors in KMO KO mice are associated with the activation of α7nAChR. PMID: 33607168 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Fujigaki S, Fujigaki H, Yamamoto Y, Nabeshima T, Saito K Tags: Behav Brain Res Source Type: research

Prefrontal NMDA-receptor antagonism disrupts encoding or consolidation but not retrieval of incidental context learning.
Abstract The Context Preexposure Facilitation Effect (CPFE) is a variant of contextual fear conditioning in which learning about the context, acquiring a context-shock association, and retrieval of this association occur separately across three phases (context preexposure, immediate-shock training, and retention). We have shown that prefrontal inactivation or muscarinic-receptor antagonism prior to any phase disrupts retention test freezing during the CPFE in adolescent rats (Heroux et al., 2017; Robinson-Drummer et al., 2017). Furthermore, the medial prefrontal cortex (mPFC) is the only region in which robust lea...
Source: Behavioural Brain Research - February 14, 2021 Category: Neurology Authors: Heroux NA, Horgan CJ, Stanton ME Tags: Behav Brain Res Source Type: research

Prediction errors and valence: from single units to multidimensional encoding in the amygdala.
ch MR Abstract The amygdala-one of the primary structures of the limbic system-is comprised of interconnected nuclei situated within the temporal lobe. It has a well-established role in the modulation of negative affective states, as well as in fear processing. However, its vast projections with diverse brain regions-ranging from the cortex to the brainstem-are suggestive of its more complex involvement in affective or motivational aspects of cognitive processing. The amygdala can play an invaluable role in context-dependent associative learning, unsigned prediction error learning, influencing outcome selection, a...
Source: Behavioural Brain Research - February 14, 2021 Category: Neurology Authors: Brockett AT, Vázquez D, Roesch MR Tags: Behav Brain Res Source Type: research

The causal involvement of the right supramarginal gyrus in the subjective experience of time: A hf-tRNS study.
asi L Abstract Neural populations in the supramarginal gyrus (SMG) of the right hemisphere have been shown to be involved in processing the subjective experience of time, particularly because of their selectivity to specific temporal durations. To directly investigate this relationship, we applied high-frequency transcranial Random Noise Stimulation (hf-tRNS) on the right SMG during a duration judgment task: 24 participants were required to judge the duration of a test visual stimulus (350, 450, 550, 650 ms) as shorter or longer than the duration of a reference auditory stimulus (500 ms). In half of ...
Source: Behavioural Brain Research - February 13, 2021 Category: Neurology Authors: Prete G, Lucafò C, Malatesta G, Tommasi L Tags: Behav Brain Res Source Type: research

Effects of handling on the behavioural phenotype of the neuregulin 1 type III transgenic mouse model for schizophrenia.
In conclusion, handling methods have a significant impact on a variety of behavioural domains thus the impact of routine handling procedures need be considered when testing behavioural phenotypes. Handling did not change the main schizophrenia-relevant characteristics of Nrg1 III tg mice but affected the acoustic startle-response in a genotype- and sex-specific manner. Future research should evaluate the effect of handling on other genetic models. PMID: 33588020 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 12, 2021 Category: Neurology Authors: Guerra S, Chesworth R, Weickert CS, Karl T Tags: Behav Brain Res Source Type: research

An Analysis of Fear Inhibition and Fear Extinction in a Sample of Veterans with Obstructive Sleep Apnea (OSA): Implications for Co-morbidity with Post-Traumatic Stress Disorder (PTSD).
Abstract Obstructive sleep apnea (OSA) is a respiratory condition characterized by interrupted sleep due to repeated, temporary collapse of the soft tissue of the upper airway that can lead to a cascade of physiological and psychological adverse health outcomes. The most common therapeutic interventions for OSA patients include the application of continuous positive airway pressure (CPAP) which acts to keep the airway open and, as such, provides less interrupted and more restorative sleep. Improved sleep has been linked to more efficacious treatments for psychiatric conditions most notably those that include cogni...
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Reist C, Jovanovic T, Kantarovich D, Weingast L, Hollifield M, Novin M, Khalaghizadeh S, Jafari B, George R, Riser M, Woodford J, Norrholm SD Tags: Behav Brain Res Source Type: research

Modulation of glutamatergic functional connectivity by a prototypical antipsychotic: translational inference from a postsynaptic density Immediate-Early Gene-based network analysis.
Abstract BACKGROUND: Although extensively studied, the effect of antipsychotics is not completely understood at a network level. We tested the hypothesis that acute administration of haloperidol would modulate functional connectivity of brain regions relevant to schizophrenia pathophysiology. To assess putative changes in brain network properties and regional interactivity, we studied the expression ofHomer1a, an Immediate Early Gene (IEG) demonstrated to be induced by antipsychotic administration and coding for a protein involved in glutamatergic synapses remodeling. METHODS: Sprague-Dawley rats (n =&...
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Barone A, Signoriello S, Latte G, Vellucci L, Giordano G, Avagliano C, Buonaguro EF, Marmo F, Tomasetti C, Iasevoli F, de Bartolomeis A Tags: Behav Brain Res Source Type: research

tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators.
This study aimed to evaluate the effects of transcranial direct current stimulation (tDCS), treadmill exercise, or both, on anxiety-like behavior and associated growth factors and inflammatory markers in the hippocampus and sciatic nerve of rats with neuropathic pain. Male Wistar rats (n = 216) were subjected to sham-surgery or sciatic nerve constriction for pain induction. Fourteen days following neuropathic pain establishment, either bimodal tDCS, treadmill exercise, or a combination of both was used for 20 minutes a day for 8 consecutive days. The elevated plus-maze test was used to assess anxiety-l...
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Lopes BC, Medeiros LF, Stein DJ, Cioato SG, de Souza VS, Medeiros HR, Sanches PRS, Fregni F, Caumo W, Torres ILS Tags: Behav Brain Res Source Type: research

Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice.
CONCLUSION: Taken together, these findings suggest that while acute antipsychotic treatment may be beneficial in management of bipolar mania, more targeted therapeutics may be necessary for long-term treatment. Specific investigation into DAT-targeting drugs could improve future treatment of bipolar mania. PMID: 33577882 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Cope ZA, Kenton JA, Minassian A, Martin MV, Perry W, Bundgaard C, Arnt J, van Enkhuizen J, Geyer MA, Young JW Tags: Behav Brain Res Source Type: research

Light at night during development in mice has modest effects on adulthood behavior and neuroimmune activation.
Abstract Exposure to light at night (LAN) can disrupt the circadian system, thereby altering neuroimmune reactivity and related behavior. Increased exposure to LAN affects people of all ages - and could have particularly detrimental effects during early-life and adolescence. Despite this, most research on the behavioral and physiological effects of LAN has been conducted in adult animals. Here we evaluated the effects of dim LAN during critical developmental windows on adulthood neuroimmune function and affective/sickness behaviors. Male and female C57BL/6 J mice were exposed to dim LAN [12:12 light (150&th...
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Chen R, Weitzner AS, McKennon LA, Fonken LK Tags: Behav Brain Res Source Type: research

Auditory environmental enrichment prevents anxiety-like behavior, but not cortisol responses, evoked by 24-h social isolation.
Abstract The zebrafish (Danio rerio) is widely used as a promising translational model organism for studying various brain disorders. Zebrafish are also commonly used in behavioral and drug screening assays utilizing individually tested (socially isolated) fish. Various sounds emerge as important exogenous factors that may affect fish behavior. Mounting evidence shows that musical/auditory environmental enrichment can improve welfare of laboratory animals, including fishes. Here, we show that auditory environmental enrichment mitigates anxiogenic-like effects caused by acute social isolation in adult zebrafish. Th...
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Marchetto L, Barcellos LJG, Koakoski G, Soares SM, Pompermaier A, Maffi VC, Costa R, da Silva CG, Zorzi NR, Demin KA, Kalueff AV, de Alcantara Barcellos HH Tags: Behav Brain Res Source Type: research

Neurodevelopmental testing of mice in the neonatal period does not affect their locomotor activity, depressive- and anxiety-like behaviour in adolescence.
urecká R, Šebeková K Abstract Neonatal life is a sensitive period of brain plasticity. There are concerns that pre-weaning handling may therefore alter behavioural phenotype in adolescence or adulthood. Since neurodevelopment tests require daily manipulation with pups, later behavioural outcomes might be biased by repeated handling during suckling period. The aim of our study was to assess whether daily neurodevelopmental testing would cause alterations in behavioural phenotype. Sixty-four CD1 mice were randomized to tested and not tested group. In the tested group, maturation of physical feat...
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Šarayová V, Mihalovičová L, Miláček D, Gurecká R, Šebeková K Tags: Behav Brain Res Source Type: research

Correlation of Distinct Behaviors to the Modified Expression of Cerebral Shank1,3 and BDNF in Two Autistic Animal Models.
Facciolo RM Abstract Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder featuring altered neuronal circuitry and consequently impaired social interactions, restrictive interests plus repetitive stereotypic activities. In the present study, differentiated behaviors of valproic (VPA) and propionic (PPA) acid-mediated autism rats were correlated to cerebral scaffolding proteins (Shank1,3) and BDNF expression variations. Sprague-Dawley offspring that received VPA during pregnancy displayed a notably diminished permanence (-78%, p 
Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Alò R, Olivito I, Fazzari G, Zizza M, Di Vito A, Avolio E, Mandalà M, Bruno R, Tullio B, Canonaco M, Facciolo RM Tags: Behav Brain Res Source Type: research

Cannabidiol efficiently suppressed the acquisition and expression of methamphetamine-induced conditioned place preference in the rat.
Abstract Methamphetamine (MET) is one of the most prevalently abused psychostimulants in the world with drastic repercussions. Several studies emphasized the inhibitory effect of Cannabidiol (CBD) on the reward properties of psychostimulants. The current investigation utilized conditioned place preference (CPP) to assay CBD's impact on MET's reward characteristic, including acquisition and expression phases of MET-induced CPP. Like our prior researches, animals received MET (1 mg/kg; sc) in a five-day schedule to induce CPP. The rats were given intracerebroventricular (ICV) microinjection of CBD (2, 10, and...
Source: Behavioural Brain Research - February 8, 2021 Category: Neurology Authors: Anooshe M, Nouri K, Karimi-Haghighi S, Mousavi Z, Haghparast A Tags: Behav Brain Res Source Type: research

Serotonergic modulation of basolateral amygdala nucleus in the extinction of reward-driven learning: the role of 5-HT bioavailability and 5-HT1A receptor.
Abstract Serotonin (5-HT) neurotransmission has been associated with reward-related behaviour. Moreover, the serotonergic system modulates the basolateral amygdala (BLA), a structure involved in reward encoding, and reward prediction error. However, the role played by 5-HT on BLA during a reward-driven task has not been fully elucidated. In this paper, we investigated whether serotonergic modulation of the BLA is involved in reward-driven learning. To this end, we trained Long Evans rats in an operant conditioning task, and examined the effects of fluoxetine treatment (a selective serotonin reuptake inhibitor, 10&...
Source: Behavioural Brain Research - February 8, 2021 Category: Neurology Authors: Pereyra AE, Mininni CJ, Zanutto BS Tags: Behav Brain Res Source Type: research

Disruptions of Cortico-Kinematic Interactions in Parkinson's Disease.
In this study, we aim to explore how PD affects cortico-kinematic interactions. Electroencephalographic (EEG) and kinematic data were recorded from seven healthy participants and eight participants diagnosed with PD during a set of self-paced finger tapping tasks. Event-related desynchronization (ERD) was compared between groups in the α (8-14 Hz), low-ß (14-20 Hz), and high-ß (20-35 Hz) frequency bands to investigate between-group differences in the cortical activities associated with movement. Average kinematic peak amplitudes and latencies were extracted alongside Sample Entropy (S...
Source: Behavioural Brain Research - February 8, 2021 Category: Neurology Authors: McLinden J, Deligani RJ, Abtahi MR, Akbar U, Mankodiya K, Shahriari Y Tags: Behav Brain Res Source Type: research

Role of 5-ht1a and 5-ht2c receptors of the dorsal periaqueductal gray in the anxiety- and panic-modulating effects of antidepressants in rats.
ROLE OF 5-HT1A AND 5-HT2C RECEPTORS OF THE DORSAL PERIAQUEDUCTAL GRAY IN THE ANXIETY- AND PANIC-MODULATING EFFECTS OF ANTIDEPRESSANTS IN RATS. Behav Brain Res. 2021 Feb 08;:113159 Authors: Vilela-Costa HH, Maraschin JC, Casarotto PC, Sant'Ana AB, de Bortoli VC, Vicente MA, de Campos AC, Guimarães FS, Zangrossi H Abstract Antidepressant drugs are first-line treatment for panic disorder. Facilitation of 5-HT1A receptor-mediated neurotransmission in the dorsal periaqueductal gray (dPAG), a key panic-associated area, has been implicated in the panicolytic effect of the selective serotonin reuptake ...
Source: Behavioural Brain Research - February 8, 2021 Category: Neurology Authors: Vilela-Costa HH, Maraschin JC, Casarotto PC, Sant'Ana AB, de Bortoli VC, Vicente MA, de Campos AC, Guimarães FS, Zangrossi H Tags: Behav Brain Res Source Type: research

Maternal Antibiotic Administration During a Critical Developmental Window Has Enduring Neurobehavioural Effects in Offspring Mice.
Abstract Rates of perinatal maternal antibiotic use have increased in recent years linked to prophylactic antibiotic use following Caesarean section delivery. This antibiotic use is necessary and beneficial in the short-term; however, long-term consequences on brain and behaviour have not been studied in detail. Here, we endeavoured to determine whether maternal administration of antibiotics during a critical window of development in early life has lasting effects on brain and behaviour in offspring mice. To this end we studied two different antibiotic preparations (single administration of Phenoxymethylpenicillin...
Source: Behavioural Brain Research - February 8, 2021 Category: Neurology Authors: O'Connor R, Moloney GM, Fulling C, O'Riordan K, Fitzgerald P, Thomaz B, Schellekens H, Dinan TG, Cryan JF Tags: Behav Brain Res Source Type: research

The role of pro- and mature neurotrophins in the depression.
Abstract Neurotrophic factors, which can provide nutritional support to neurons and neuronal cells, also played an important role in their proliferation and survival. As signaling molecules, it also mediated the learning, memory and other activities in the brain. The latest study shows that neurotrophic factors have diametrically opposing effects of the pro- and mature form through distinct receptors. In this review, we summarize the different forms of neurotrophic factors, related receptors, and the corresponding biological effects. More importantly, we expounded the physiology and pathology mechanisms of brain-d...
Source: Behavioural Brain Research - February 4, 2021 Category: Neurology Authors: Xue Y, Liang H, Yang R, Deng K, Tang M, Zhang M Tags: Behav Brain Res Source Type: research

Methylene blue and photobiomodulation recover cognitive impairment in hepatic encephalopathy through different effects on cytochrome c-oxidase.
ias N Abstract Mitochondrial dysfunction plays a central role in hepatic encephalopathy (HE), due to changes in enzyme cytochrome c-oxidase (CCO), causing a decline in brain metabolism. We used an HE animal model and applied intracranial administration of methylene blue (MB) and transcranial photobiomodulation (PBM), both targeting CCO, to determine their differential effects on recovering cognition. Five groups of rats were used: sham-operated group + saline (SHAM + SAL, n = 6), hepatic encephalopathy + SAL (HE + SAL, n = 7), SHAM...
Source: Behavioural Brain Research - February 4, 2021 Category: Neurology Authors: Méndez M, Fidalgo C, Arias JL, Arias N Tags: Behav Brain Res Source Type: research

Intermittent fasting promotes anxiolytic-like effects unrelated to synaptic mitochondrial function and BDNF support.
In conclusion, IF exerts anxiolytic-like effect not associated with modulation in synaptic neuronergetics or expression of neurotrophic proteins. These results highlight a potential benefit of intermittent fasting as a nutritional intervention in anxiety-related disorders. PMID: 33549686 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 4, 2021 Category: Neurology Authors: Carteri RB, Menegassi LN, Feldmann M, Kopczynski A, Rodolphi MS, Strogulski NR, Almeida AS, Marques DM, Porciúncula LO, Portela LV Tags: Behav Brain Res Source Type: research

Protective effect of ginsenoside Rb1 against chronic restraint stress (CRS)-induced memory impairments in rats.
In this study, rats were subjected to CRS (6 h/day) for 28 days. Thereafter, behavioural tests including reward-directed instrumental conditioning task (RICT) and the Morris water maze (MWM) task were conducted. Administered of Rb1 (6.75 and 13.5 mg/kg, i.p.) remarkably ameliorated the memory impairments caused by CRS as evident from the results of RICT and MWM task, and this effect was accompanied by noticeable alterations in the levels of oxidative markers (superoxide dismutase, catalase, and lipid peroxidation) in the hippocampus. Additionally, Rb1 reduced the ratio of Bax:Bcl-2 and the expression of cleav...
Source: Behavioural Brain Research - February 2, 2021 Category: Neurology Authors: Jiang N, Wang K, Zhang Y, Huang H, Lv JW, Wang Q, Wang HX, Xia TJ, Liu XM Tags: Behav Brain Res Source Type: research

Pharmacotherapy of schizophrenia: Mechanisms of antipsychotic accumulation, therapeutic action and failure.
CP Abstract Schizophrenia is a multi-dimensional disorder with a complex and mostly unknown etiology, leading to a severe decline in life quality. Antipsychotic drugs (APDs) remain beneficial interventions in the treatment of the disorder, but vary significantly in binding profile, clinical effects and adverse reactions. The present review summarizes the main principles of APD mechanisms of action with a particular focus on recent findings in APD accumulation and its role in the therapeutic efficacy and treatment failure. High and low doses of APDs were shown to be effective in different dimensions of antipsychot...
Source: Behavioural Brain Research - January 27, 2021 Category: Neurology Authors: Chestnykh DA, Amato D, Kornhuber J, Müller CP Tags: Behav Brain Res Source Type: research

Maternal immune activation and repeated maternal separation alter offspring conditioned avoidance response learning and antipsychotic response in male rats.
Abstract Previous work shows that repeated administration of several commonly used antipsychotic drugs, such as olanzapine (OLZ) over several days, induces an enhanced disruption of conditioned avoidance response (CAR) (termed antipsychotic sensitization) in normal adolescent and adult rats. However, it is unclear whether the same phenomenon can also be demonstrated in rat models of schizophrenia. The present study investigated OLZ sensitization in a combined maternal immune activation (MIA) and repeated maternal separation (RMS) model of schizophrenia. Sprague-Dawley male rats were first subjected to an early pre...
Source: Behavioural Brain Research - January 27, 2021 Category: Neurology Authors: Chou S, Davis C, Li M Tags: Behav Brain Res Source Type: research

Examining the non-spatial pretraining effect on a Water Maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD.
Abstract Propionic acid (PPA) is produced by enteric gut bacteria and is a dietary short chain fatty acid. Intracerebroventricular (ICV) infusions of PPA in rodents have been shown to produce behavioral changes, including adverse effects on cognition, similar to those seen in autism spectrum disorders (ASD). Previous research has shown that repeated ICV infusions of PPA result in impaired spatial learning in a Morris water maze (MWM) as evidenced by increased search latencies, fewer direct and circle swims, and more time spent in the periphery of the maze than control rats. In the current study rats were first giv...
Source: Behavioural Brain Research - January 25, 2021 Category: Neurology Authors: Mepham JR, MacFabe DF, Boon FH, Foley KA, Cain DP, Ossenkopp KP Tags: Behav Brain Res Source Type: research

High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine.
CONCLUSION: Maternal high-fat diets influence offspring anxiety-like behavior in state-anxiety tests but not in trait-anxiety test. Responsiveness to acute fluoxetine depended on maternal diet, dose and which behavioral tests were being evaluated. PMID: 33508349 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 25, 2021 Category: Neurology Authors: Cavalcanti CCL, Da Silva Aragão R, Cadena-Burbano EV, Dos Prazeres Oliveira TR, Silva JM, de Arruda Campos Benjamim R, Lago AB, de Moraes Silva EH, Costa TL, Manhães-De-Castro R Tags: Behav Brain Res Source Type: research