The effect of stress and reward on encoding future fear memories
Behav Brain Res. 2021 Sep 17:113587. doi: 10.1016/j.bbr.2021.113587. Online ahead of print.ABSTRACTPrior experience changes the way we learn about our environment. Stress predisposes individuals to developing psychological disorders, just as positive experiences protect from this eventuality (Kirkpatrick & Heller, 2014; Koenigs & Grafman, 2009; Pechtel & Pizzagalli, 2011). Yet current models of how the brain processes information often do not consider a role for prior experience. The considerable literature that examines how stress impacts the brain is an exception to this. This research demonstrates that stres...
Source: Behavioural Brain Research - September 20, 2021 Category: Neurology Authors: Lauren E DiFazio Michael Fanselow Melissa J Sharpe Source Type: research

Blockade of adenosine A < sub > 2A < /sub > receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures
Behav Brain Res. 2021 Sep 15:113585. doi: 10.1016/j.bbr.2021.113585. Online ahead of print.ABSTRACTTremor is one of the motor symptoms of Parkinson's disease (PD), present also in neuroleptic-induced parkinsonism. Tremulous jaw movements (TJMs) are suggested to be a well-validated rodent model of PD resting tremor. TJMs can be induced by typical antipsychotics and are known to be reduced by different drugs, including adenosine A2A receptor antagonists. The aim of the present study was to search for brain structures involved in the tremorolytic action of SCH58261, a selective A2A receptor antagonist, in TJMs induced by subc...
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Barbara Kosmowska Krystyna Ossowska Jadwiga Wardas Source Type: research

Overexpression of miR-132-3p contributes to neuronal protection in in vitro and in vivo models of Alzheimer's disease
Behav Brain Res. 2021 Sep 15:113584. doi: 10.1016/j.bbr.2021.113584. Online ahead of print.ABSTRACTOne of the neuropathological hallmarks of Alzheimer's disease (AD) is accumulation and deposition of amyloid-beta (Aβ1-42) plaques in the hippocampus. Recently, microRNAs (miRNAs), have been demonstrated to play an essential role in AD. We have previously demonstrated that miR-132-3p exerts neuroprotection via regulating histone deacetylase 3 (HDAC3) in a mouse model of AD. In the present study, we further unveiled neuroprotective roles of miR-132-3p in transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mice com...
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Chong Zeng Xingjun Meng Dongmei Mai Kai Xu Shaogang Qu Source Type: research

The resting-state cerebro-cerebellar function connectivity and associations with verbal working memory performance
Behav Brain Res. 2021 Sep 15:113586. doi: 10.1016/j.bbr.2021.113586. Online ahead of print.ABSTRACTThe cerebellum plays an important role in cognitive functions through connecting with the cerebral areas. However, the relationship between the resting-state functional connectivity (FC) pattern of human cerebro-cerebellar circuits and cognition is not fully understood. The present study investigated the FC pattern of human cerebro-cerebellar circuits and their associations with verbal working memory performance (an n-back task with three subtasks: 0-back, 1-back, and 2-back) through resting-state functional magnetic resonanc...
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Yanyan Li Lihao Yang Lihua Li Yuanjun Xie Peng Fang Source Type: research

Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice
In conclusion, oral administration of the newly synthesized phenylpiperazines produced anxiolytic- and antidepressant-like effects in behavioral tests, putatively in part through the activation of 5-HT1A receptors.PMID:34536431 | DOI:10.1016/j.bbr.2021.113582 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Lorrane Kelle da Silva Moreira Rafaela Ribeiro Silva Dayane Moreira da Silva Mirella Andrade Silva Mendes Adriane Ferreira de Brito Fl ávio Souza de Carvalho Germ án Sanz Marcella Ferreira Rodrigues Artur Christian Garcia da Silva Douglas Vieira Thomaz Source Type: research

Blockade of adenosine A < sub > 2A < /sub > receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures
Behav Brain Res. 2021 Sep 15:113585. doi: 10.1016/j.bbr.2021.113585. Online ahead of print.ABSTRACTTremor is one of the motor symptoms of Parkinson's disease (PD), present also in neuroleptic-induced parkinsonism. Tremulous jaw movements (TJMs) are suggested to be a well-validated rodent model of PD resting tremor. TJMs can be induced by typical antipsychotics and are known to be reduced by different drugs, including adenosine A2A receptor antagonists. The aim of the present study was to search for brain structures involved in the tremorolytic action of SCH58261, a selective A2A receptor antagonist, in TJMs induced by subc...
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Barbara Kosmowska Krystyna Ossowska Jadwiga Wardas Source Type: research

Overexpression of miR-132-3p contributes to neuronal protection in in vitro and in vivo models of Alzheimer's disease
Behav Brain Res. 2021 Sep 15:113584. doi: 10.1016/j.bbr.2021.113584. Online ahead of print.ABSTRACTOne of the neuropathological hallmarks of Alzheimer's disease (AD) is accumulation and deposition of amyloid-beta (Aβ1-42) plaques in the hippocampus. Recently, microRNAs (miRNAs), have been demonstrated to play an essential role in AD. We have previously demonstrated that miR-132-3p exerts neuroprotection via regulating histone deacetylase 3 (HDAC3) in a mouse model of AD. In the present study, we further unveiled neuroprotective roles of miR-132-3p in transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mice com...
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Chong Zeng Xingjun Meng Dongmei Mai Kai Xu Shaogang Qu Source Type: research

The resting-state cerebro-cerebellar function connectivity and associations with verbal working memory performance
Behav Brain Res. 2021 Sep 15:113586. doi: 10.1016/j.bbr.2021.113586. Online ahead of print.ABSTRACTThe cerebellum plays an important role in cognitive functions through connecting with the cerebral areas. However, the relationship between the resting-state functional connectivity (FC) pattern of human cerebro-cerebellar circuits and cognition is not fully understood. The present study investigated the FC pattern of human cerebro-cerebellar circuits and their associations with verbal working memory performance (an n-back task with three subtasks: 0-back, 1-back, and 2-back) through resting-state functional magnetic resonanc...
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Yanyan Li Lihao Yang Lihua Li Yuanjun Xie Peng Fang Source Type: research

Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice
In conclusion, oral administration of the newly synthesized phenylpiperazines produced anxiolytic- and antidepressant-like effects in behavioral tests, putatively in part through the activation of 5-HT1A receptors.PMID:34536431 | DOI:10.1016/j.bbr.2021.113582 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 18, 2021 Category: Neurology Authors: Lorrane Kelle da Silva Moreira Rafaela Ribeiro Silva Dayane Moreira da Silva Mirella Andrade Silva Mendes Adriane Ferreira de Brito Fl ávio Souza de Carvalho Germ án Sanz Marcella Ferreira Rodrigues Artur Christian Garcia da Silva Douglas Vieira Thomaz Source Type: research

Dopaminergic but not Cholinergic Neurodegeneration is Correlated with Gait Disturbances in PINK1 Knockout Rats
Behav Brain Res. 2021 Sep 14:113575. doi: 10.1016/j.bbr.2021.113575. Online ahead of print.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disorder characterized by gait dysfunction in later stages of the disease. PD hallmarks include a decrease in stride length, run speed, and swing time; an increase in stride time, stance time, and base of support; dopaminergic degeneration in the basal ganglia; and cholinergic degeneration in the pedunculopontine nucleus (PPN). A progressive animal model of PD is needed to identify treatments for gait dysfunction. The goal of this study was to quantify progressive ga...
Source: Behavioural Brain Research - September 17, 2021 Category: Neurology Authors: V M DeAngelo J D Hilliard G C McConnell Source Type: research

Effect of dimethyl fumarate on the changes in the medial prefrontal cortex structure and behaviour in the poly(I:C)-induced maternal immune activation model of schizophrenia in the male mice
CONCLUSION: These findings support the idea of using anti-inflammatory agents as adjunctive therapy in patients with SCZ.PMID:34530042 | DOI:10.1016/j.bbr.2021.113581 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 16, 2021 Category: Neurology Authors: Farshid Bagheri Anahid Safari Mohammad Reza Namavar Source Type: research

Dopamine D < sub > 1 < /sub > -like receptors in prelimbic, but not infralimbic, medial prefrontal cortex contribute to chronic stress-induced increases in cue-induced relapse to palatable food seeking during forced abstinence
Behav Brain Res. 2021 Sep 13:113583. doi: 10.1016/j.bbr.2021.113583. Online ahead of print.ABSTRACTChronic stress exposure causes increased vulnerability to future relapse-like behavior in male, but not female, rats with a history of palatable food self-administration. These effects are mediated by dopamine D1-like receptors, but the anatomical location of chronic stress' dopaminergic mechanism is not known. Thus, male rats were trained to respond for palatable food pellets in daily sessions. During subsequent forced abstinence from food self-administration, stress was manipulated (0 or 3hr restraint/day for 7 days). Rats ...
Source: Behavioural Brain Research - September 16, 2021 Category: Neurology Authors: Kevin T Ball Guy M Bennardo Jonathan Roe Kyle J Wunderlich Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

The Interaction between Sexual Reward/ Deprivation and the Acquisition, Extinction and Reinstatement of Morphine-Seeking Behavior
Behav Brain Res. 2021 Sep 8:113579. doi: 10.1016/j.bbr.2021.113579. Online ahead of print.ABSTRACTNatural rewards and abused drugs affect the function of the common brain's reward system. Interaction between social and drug rewards can change the vulnerability to development of drug addiction. Here, we investigate the effects of sexual experience and sex deprivation on the acquisition, maintenance, and drug prime-induced reinstatement of morphine-seeking behavior in male mice using conditioned place preference (CPP). CPP induced with morphine (3, 5, 7mg/kg, s.c. for 3 days) lasted for 10 days after cessation of morphine tr...
Source: Behavioural Brain Research - September 11, 2021 Category: Neurology Authors: Marjan Nikbakhtzadeh Ehsan Raeis-Abdollahi Esmail Riahi Reza Arezoomandan Source Type: research

Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus
Behav Brain Res. 2021 Sep 8:113578. doi: 10.1016/j.bbr.2021.113578. Online ahead of print.ABSTRACTPositive allosteric modulators (PAMs) of α5GABAA receptors (α5GABAARs) are emerging as potential therapeutics for a range of neuropsychiatric disorders. However, their role in memory processing of healthy animals is not sufficiently examined. We tested the effects of MP-III-022 (1mg/kg, 2.5mg/kg and 10mg/kg), a PAM known to be selective for α5GABAARs and devoid of prominent side-effects, in different behavioral paradigms (Morris water maze, novel object recognition test and social novelty discrimination) and ...
Source: Behavioural Brain Research - September 11, 2021 Category: Neurology Authors: Anja Santra č Bojan Batini ć Tamara Timi ć Stamenić Jovana Aran đelović Dishary Sharmin Daniel E Knutson James M Cook Miroslav M Savi ć Source Type: research

Sociability, but not spatial memory, is correlated with regional brain volume variation in the striped mouse Rhabdomys spp
Behav Brain Res. 2021 Sep 8:113567. doi: 10.1016/j.bbr.2021.113567. Online ahead of print.ABSTRACTLocal environmental conditions associated with different geographic areas may elicit variations in behavioural responses in animals, leading to concomitant differences in functional brain region volumes. We investigated the behavioural correlates of hippocampus and amygdala volumes in three sister taxa of the murid rodent genus Rhabdomys, occurring in different environments. We used a Barnes maze to test spatial memory, dyadic encounters to test social behaviour, and histological brain sections to calculate hippocampus and amy...
Source: Behavioural Brain Research - September 11, 2021 Category: Neurology Authors: Candice Nikita Neves Neville Pillay Source Type: research

Carbamylated Erythropoietin Improves Recognition Memory by Modulating Microglia in a rat model of Pain
Behav Brain Res. 2021 Sep 7:113576. doi: 10.1016/j.bbr.2021.113576. Online ahead of print.ABSTRACTPatients with chronic pain often complain about memory impairments. Experimental studies have shown neuroprotective effects of Carbamylated erythropoietin (Cepo-Fc) in the treatment of cognitive dysfunctions. However, little is currently known about its precise molecular mechanisms in a model of inflammatory pain. Therefore, this study aimed to investigate neuroprotective effects of Cepo-Fc against cognitive impairment induced by the inflammatory model of Complete Freund's Adjuvant (CFA). Carbamylated erythropoietin was admini...
Source: Behavioural Brain Research - September 10, 2021 Category: Neurology Authors: Nasser Rahmani Mola Mohammadi Homa Manaheji Nader Maghsoudi Hermann Katinger Mansoureh Baniasadi Jalal Zaringhalam Source Type: research

Differential organization of open field behavior in mice following acute or chronic simulated GCR exposure
Behav Brain Res. 2021 Sep 7:113577. doi: 10.1016/j.bbr.2021.113577. Online ahead of print.ABSTRACTAstronauts undertaking deep space travel will receive chronic exposure to the mixed spectrum of particles that comprise Galactic Cosmic Radiation (GCR). Exposure to the different charged particles of varied fluence and energy that characterize GCR may impact neural systems that support performance on mission critical tasks. Indeed, growing evidence derived from years of terrestrial-based simulations of the space radiation environment using rodents has indicated that a variety of exposure scenarios can result in significant and...
Source: Behavioural Brain Research - September 10, 2021 Category: Neurology Authors: E A Schaeffer A A Blackwell J R Osterlund Oltmanns R Einhaus R Lake C Piwowar Hein J E Baulch C L Limoli S T Ton G L Kartje D G Wallace Source Type: research

Carbamylated Erythropoietin Improves Recognition Memory by Modulating Microglia in a rat model of Pain
Behav Brain Res. 2021 Sep 7:113576. doi: 10.1016/j.bbr.2021.113576. Online ahead of print.ABSTRACTPatients with chronic pain often complain about memory impairments. Experimental studies have shown neuroprotective effects of Carbamylated erythropoietin (Cepo-Fc) in the treatment of cognitive dysfunctions. However, little is currently known about its precise molecular mechanisms in a model of inflammatory pain. Therefore, this study aimed to investigate neuroprotective effects of Cepo-Fc against cognitive impairment induced by the inflammatory model of Complete Freund's Adjuvant (CFA). Carbamylated erythropoietin was admini...
Source: Behavioural Brain Research - September 10, 2021 Category: Neurology Authors: Nasser Rahmani Mola Mohammadi Homa Manaheji Nader Maghsoudi Hermann Katinger Mansoureh Baniasadi Jalal Zaringhalam Source Type: research

Differential organization of open field behavior in mice following acute or chronic simulated GCR exposure
Behav Brain Res. 2021 Sep 7:113577. doi: 10.1016/j.bbr.2021.113577. Online ahead of print.ABSTRACTAstronauts undertaking deep space travel will receive chronic exposure to the mixed spectrum of particles that comprise Galactic Cosmic Radiation (GCR). Exposure to the different charged particles of varied fluence and energy that characterize GCR may impact neural systems that support performance on mission critical tasks. Indeed, growing evidence derived from years of terrestrial-based simulations of the space radiation environment using rodents has indicated that a variety of exposure scenarios can result in significant and...
Source: Behavioural Brain Research - September 10, 2021 Category: Neurology Authors: E A Schaeffer A A Blackwell J R Osterlund Oltmanns R Einhaus R Lake C Piwowar Hein J E Baulch C L Limoli S T Ton G L Kartje D G Wallace Source Type: research

Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks
In this study, cognitive function in Reln-del mice was assessed using touchscreen-based visual discrimination (VD) and reversal learning (RL) tasks. Reln-del mice showed normal learning in the simple VD task, but the learning was delayed in the complex VD task as compared to their wild-type (WT) littermates. In the RL task, sessions were divided into early perseverative phase (sessions with
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Jingzhu Liao Geyao Dong Bolati Wulaer Masahito Sawahata Hiroyuki Mizoguchi Daisuke Mori Norio Ozaki Toshitaka Nabeshima Taku Nagai Kiyofumi Yamada Source Type: research

Support for the parental practice hypothesis: subadult prairie voles exhibit similar behavioral and neural profiles when alloparenting kin and non-kin
This study examined alloparental behaviors and neural responses in prairie voles (Microtus ochrogaster), a species that engages in alloparental behavior. Subadult (independent, yet sexually immature) male prairie voles were exposed to one of four stimuli: same-age sibling, neonatal sibling, unrelated neonate, or inanimate neonate-sized object. We assessed alloparental behaviors and quantified cFos protein expression in oxytocin and vasopressin neuronal populations of the paraventricular nucleus of the hypothalamus and the supraoptic nucleus of the hypothalamus in response to stimulus exposure. We detected no differences in...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Caitlyn J Finton Aubrey M Kelly Alexander G Ophir Source Type: research

Influence of acid-sensing ion channel blocker on behavioral responses in a zebrafish model of acute visceral pain
Behav Brain Res. 2021 Sep 6:113565. doi: 10.1016/j.bbr.2021.113565. Online ahead of print.ABSTRACTAcid-sensing ion channels (ASICs) play significant roles in numerous neurological and pathological conditions, including pain. Although acid-induced nociception has been characterized previously in zebrafish, the contribution of ASICs in modulating pain-like behaviors is still unknown. Here, we investigated the contribution of amiloride, a nonselective ASICs blocker, in negatively modulating specific behavioral responses in a zebrafish-based model of acute visceral pain. We verified that intraperitoneal injection (i.p.) of 0.2...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Isaac A Adedara Fabiano V Costa Eduarda Biasuz Julia Canzian Ebenezer O Farombi Denis B Rosemberg Source Type: research

Activation of CB1 pathway in the perirhinal cortex is necessary but not sufficient for destabilization of contextual fear memory in rats
Behav Brain Res. 2021 Sep 6:113573. doi: 10.1016/j.bbr.2021.113573. Online ahead of print.ABSTRACTAccording to the reconsolidation theory, memories can be modified through the destabilization-reconsolidation process. The rodent perirhinal cortex (PER; Brodmann areas 35 and 36) critically participates in the process of fear conditioning. Previous studies showed that some of the parahippocampal regions are critical for contextual fear memory reconsolidation. In our research, through a three-day paradigm of CFC, we showed that protein synthesis in PER of rats is required for memory reconsolidation, and activation of CB1 pathw...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Che Jiang Xiaona Wu Jiajia Wang Chunyong Li Gaoquan Luo Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Hypothermic preconditioning attenuates hypobaric hypoxia induced spatial memory impairment in rats
Behav Brain Res. 2021 Sep 6:113568. doi: 10.1016/j.bbr.2021.113568. Online ahead of print.ABSTRACTHypobaric Hypoxia (HH) is known to cause oxidative stress in the brain that leads to spatial memory deficit and neurodegeneration. For decades therapeutic hypothermia is used to treat global and focal ischemia in preserving brain functions that proved to be beneficial in humans and rodents. Considering these previous reports, the present study was designed to establish the therapeutic potential of hypothermia preconditioning on HH induced spatial memory, biochemical and morphological changes in adult rats. Male Sprague Dawley ...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Rahul Ranjan None Amitabh Dipti N Prasad Ekta Kohli Source Type: research

Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3?
Behav Brain Res. 2021 Sep 6:113566. doi: 10.1016/j.bbr.2021.113566. Online ahead of print.ABSTRACTThe present study evaluated the function of the right and left CA3 of the dorsal hippocampus (dHPC) in the processing of (i) recognition memory, (ii) recent and remote spatial memory, (iii) working memory and (iv) navigation strategy. Wistar rats were divided into four experimental groups: vehicle group (VG), animals received a bilateral injection of phosphate-saline buffer (PBS) in both right and left dorsal CA3; dHPC-R group, animals received an injection of ibotenic acid (IBO) in the right dorsal CA3; dHPC-L group, animals ...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Gabrielle Araujo Pimentel Ariela Maltarolo Crestani Luiz Henrique Florindo Source Type: research

Increased intensity of unintended mirror muscle contractions after cervical spinal cord injury are associated with changes in interhemispheric and corticomuscular coherences
Behav Brain Res. 2021 Sep 6:113563. doi: 10.1016/j.bbr.2021.113563. Online ahead of print.ABSTRACTMirror contractions refer to unintended contractions of the contralateral homologous muscles during voluntary unilateral contractions or movements. Exaggerated mirror contractions have been found in several neurological diseases and indicate dysfunction or lesion of the cortico-spinal pathway. The present study investigates mirror contractions and the associated interhemispheric and corticomuscular interactions in adults with SCI - who present a lesion of the cortico-spinal tract - compared to able-bodied participants (AB). Ei...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Joseph Tisseyre Sylvain Cremoux David Amarantini Jessica Tallet Source Type: research

Sodium hydrosulfide reverses β < sub > 2 < /sub > -microglobulin-induced depressive-like behaviors of male Sprague-Dawley rats: involving improvement of synaptic plasticity and enhancement of Warburg effect in hippocampus
CONCLUSION: H2S prevents β2m-induced depressive-like behaviors, which is involved in improvement of hippocampal synaptic plasticity as a result of enhancement of hippocampal Warburg effect.PMID:34499939 | DOI:10.1016/j.bbr.2021.113562 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: San-Qiao Yang Yi-Yun Tang Dan Zeng Qing Tian Hai-Jun Wei Chun-Yan Wang Ping Zhang Yong-Jun Chen Wei Zou Xiao-Qing Tang Source Type: research

Morphological changes in the basolateral amygdala and behavioral disruptions associated with social isolation
Behav Brain Res. 2021 Sep 6:113572. doi: 10.1016/j.bbr.2021.113572. Online ahead of print.ABSTRACTSocial isolation and the disruption of established social bonds contribute to several physical and psychological health issues. Animal models are a useful tool for investigating consequences of social stress, including social isolation. The current study examined morphological changes in the basolateral amygdala (BLA) and affect-related behavioral and endocrine changes, due to prolonged social isolation using the translational prairie vole model (Microtus ochrogaster). Adult male prairie voles were either socially paired (cont...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Michael J Hylin W Tang Watanasriyakul Natalee Hite Neal McNeal Angela J Grippo Source Type: research

Age group differences in learning-related activity reflect task stage, not learning stage
Behav Brain Res. 2021 Sep 6:113570. doi: 10.1016/j.bbr.2021.113570. Online ahead of print.ABSTRACTHealthy aging is accompanied by declines in the ability to learn associations between events, even when their relationship cannot be described. Previous functional magnetic resonance imaging (fMRI) studies have attributed these implicit associative learning (IAL) deficits to differential engagement of the hippocampus and basal ganglia in older relative to younger adults in early and late stages of the task, respectively. However, these task stages have been confounded with age group differences in learning performance that eme...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Jenna L Merenstein Jessica R Petok Ilana J Bennett Source Type: research

Chronic Infusions of Mecamylamine into the Medial Habenula: Effects on Nicotine Self-Administration in Rats
This study determined that medial habenular nicotinic receptors are important for nicotine reinforcement. Baseline level of performance makes a crucial difference for the involvement of habenular mechanisms in nicotine reinforcement with nicotinic activation being important for maintaining nicotine self-administration for those with lower levels of baseline self-administration and the opposite effect with subjects with higher levels of baseline self-administration.PMID:34499942 | DOI:10.1016/j.bbr.2021.113574 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Edward D Levin Corinne Wells Susan Slade Joshua Johnson Ann Petro Amir H Rezvani Jed E Rose Source Type: research

Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks
In this study, cognitive function in Reln-del mice was assessed using touchscreen-based visual discrimination (VD) and reversal learning (RL) tasks. Reln-del mice showed normal learning in the simple VD task, but the learning was delayed in the complex VD task as compared to their wild-type (WT) littermates. In the RL task, sessions were divided into early perseverative phase (sessions with
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Jingzhu Liao Geyao Dong Bolati Wulaer Masahito Sawahata Hiroyuki Mizoguchi Daisuke Mori Norio Ozaki Toshitaka Nabeshima Taku Nagai Kiyofumi Yamada Source Type: research

Support for the parental practice hypothesis: subadult prairie voles exhibit similar behavioral and neural profiles when alloparenting kin and non-kin
This study examined alloparental behaviors and neural responses in prairie voles (Microtus ochrogaster), a species that engages in alloparental behavior. Subadult (independent, yet sexually immature) male prairie voles were exposed to one of four stimuli: same-age sibling, neonatal sibling, unrelated neonate, or inanimate neonate-sized object. We assessed alloparental behaviors and quantified cFos protein expression in oxytocin and vasopressin neuronal populations of the paraventricular nucleus of the hypothalamus and the supraoptic nucleus of the hypothalamus in response to stimulus exposure. We detected no differences in...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Caitlyn J Finton Aubrey M Kelly Alexander G Ophir Source Type: research

Influence of acid-sensing ion channel blocker on behavioral responses in a zebrafish model of acute visceral pain
Behav Brain Res. 2021 Sep 6:113565. doi: 10.1016/j.bbr.2021.113565. Online ahead of print.ABSTRACTAcid-sensing ion channels (ASICs) play significant roles in numerous neurological and pathological conditions, including pain. Although acid-induced nociception has been characterized previously in zebrafish, the contribution of ASICs in modulating pain-like behaviors is still unknown. Here, we investigated the contribution of amiloride, a nonselective ASICs blocker, in negatively modulating specific behavioral responses in a zebrafish-based model of acute visceral pain. We verified that intraperitoneal injection (i.p.) of 0.2...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Isaac A Adedara Fabiano V Costa Eduarda Biasuz Julia Canzian Ebenezer O Farombi Denis B Rosemberg Source Type: research

Activation of CB1 pathway in the perirhinal cortex is necessary but not sufficient for destabilization of contextual fear memory in rats
Behav Brain Res. 2021 Sep 6:113573. doi: 10.1016/j.bbr.2021.113573. Online ahead of print.ABSTRACTAccording to the reconsolidation theory, memories can be modified through the destabilization-reconsolidation process. The rodent perirhinal cortex (PER; Brodmann areas 35 and 36) critically participates in the process of fear conditioning. Previous studies showed that some of the parahippocampal regions are critical for contextual fear memory reconsolidation. In our research, through a three-day paradigm of CFC, we showed that protein synthesis in PER of rats is required for memory reconsolidation, and activation of CB1 pathw...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Che Jiang Xiaona Wu Jiajia Wang Chunyong Li Gaoquan Luo Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Hypothermic preconditioning attenuates hypobaric hypoxia induced spatial memory impairment in rats
Behav Brain Res. 2021 Sep 6:113568. doi: 10.1016/j.bbr.2021.113568. Online ahead of print.ABSTRACTHypobaric Hypoxia (HH) is known to cause oxidative stress in the brain that leads to spatial memory deficit and neurodegeneration. For decades therapeutic hypothermia is used to treat global and focal ischemia in preserving brain functions that proved to be beneficial in humans and rodents. Considering these previous reports, the present study was designed to establish the therapeutic potential of hypothermia preconditioning on HH induced spatial memory, biochemical and morphological changes in adult rats. Male Sprague Dawley ...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Rahul Ranjan None Amitabh Dipti N Prasad Ekta Kohli Source Type: research

Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3?
Behav Brain Res. 2021 Sep 6:113566. doi: 10.1016/j.bbr.2021.113566. Online ahead of print.ABSTRACTThe present study evaluated the function of the right and left CA3 of the dorsal hippocampus (dHPC) in the processing of (i) recognition memory, (ii) recent and remote spatial memory, (iii) working memory and (iv) navigation strategy. Wistar rats were divided into four experimental groups: vehicle group (VG), animals received a bilateral injection of phosphate-saline buffer (PBS) in both right and left dorsal CA3; dHPC-R group, animals received an injection of ibotenic acid (IBO) in the right dorsal CA3; dHPC-L group, animals ...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Gabrielle Araujo Pimentel Ariela Maltarolo Crestani Luiz Henrique Florindo Source Type: research

Increased intensity of unintended mirror muscle contractions after cervical spinal cord injury are associated with changes in interhemispheric and corticomuscular coherences
Behav Brain Res. 2021 Sep 6:113563. doi: 10.1016/j.bbr.2021.113563. Online ahead of print.ABSTRACTMirror contractions refer to unintended contractions of the contralateral homologous muscles during voluntary unilateral contractions or movements. Exaggerated mirror contractions have been found in several neurological diseases and indicate dysfunction or lesion of the cortico-spinal pathway. The present study investigates mirror contractions and the associated interhemispheric and corticomuscular interactions in adults with SCI - who present a lesion of the cortico-spinal tract - compared to able-bodied participants (AB). Ei...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Joseph Tisseyre Sylvain Cremoux David Amarantini Jessica Tallet Source Type: research

Sodium hydrosulfide reverses β < sub > 2 < /sub > -microglobulin-induced depressive-like behaviors of male Sprague-Dawley rats: involving improvement of synaptic plasticity and enhancement of Warburg effect in hippocampus
CONCLUSION: H2S prevents β2m-induced depressive-like behaviors, which is involved in improvement of hippocampal synaptic plasticity as a result of enhancement of hippocampal Warburg effect.PMID:34499939 | DOI:10.1016/j.bbr.2021.113562 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: San-Qiao Yang Yi-Yun Tang Dan Zeng Qing Tian Hai-Jun Wei Chun-Yan Wang Ping Zhang Yong-Jun Chen Wei Zou Xiao-Qing Tang Source Type: research

Morphological changes in the basolateral amygdala and behavioral disruptions associated with social isolation
Behav Brain Res. 2021 Sep 6:113572. doi: 10.1016/j.bbr.2021.113572. Online ahead of print.ABSTRACTSocial isolation and the disruption of established social bonds contribute to several physical and psychological health issues. Animal models are a useful tool for investigating consequences of social stress, including social isolation. The current study examined morphological changes in the basolateral amygdala (BLA) and affect-related behavioral and endocrine changes, due to prolonged social isolation using the translational prairie vole model (Microtus ochrogaster). Adult male prairie voles were either socially paired (cont...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Michael J Hylin W Tang Watanasriyakul Natalee Hite Neal McNeal Angela J Grippo Source Type: research

Age group differences in learning-related activity reflect task stage, not learning stage
Behav Brain Res. 2021 Sep 6:113570. doi: 10.1016/j.bbr.2021.113570. Online ahead of print.ABSTRACTHealthy aging is accompanied by declines in the ability to learn associations between events, even when their relationship cannot be described. Previous functional magnetic resonance imaging (fMRI) studies have attributed these implicit associative learning (IAL) deficits to differential engagement of the hippocampus and basal ganglia in older relative to younger adults in early and late stages of the task, respectively. However, these task stages have been confounded with age group differences in learning performance that eme...
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Jenna L Merenstein Jessica R Petok Ilana J Bennett Source Type: research

Chronic Infusions of Mecamylamine into the Medial Habenula: Effects on Nicotine Self-Administration in Rats
This study determined that medial habenular nicotinic receptors are important for nicotine reinforcement. Baseline level of performance makes a crucial difference for the involvement of habenular mechanisms in nicotine reinforcement with nicotinic activation being important for maintaining nicotine self-administration for those with lower levels of baseline self-administration and the opposite effect with subjects with higher levels of baseline self-administration.PMID:34499942 | DOI:10.1016/j.bbr.2021.113574 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Edward D Levin Corinne Wells Susan Slade Joshua Johnson Ann Petro Amir H Rezvani Jed E Rose Source Type: research

Brief Environmental Enrichment exposure enhances contextual-induced sucrose-seeking with and without memory reactivation in rats
Behav Brain Res. 2021 Aug 30;416:113556. doi: 10.1016/j.bbr.2021.113556. Online ahead of print.ABSTRACTChronic Environmental Enrichment (EE) has been shown to prevent the relapse to addictive behaviours, such as drug-taking and -seeking. Recently, acute EE was shown to reduce cue-induced sucrose-seeking, but its effects on contextual (Cx)-induced sucrose-seeking is still unknown. Here we report the effects of brief EE exposure on Cx-induced sucrose-seeking with and without prior Cx-memory reactivation. Adult male Sprague-Dawley rats were trained to sucrose self-administration associated to a specific conditioning Cx (CxA),...
Source: Behavioural Brain Research - September 2, 2021 Category: Neurology Authors: N Pintori A Piva V Guardiani I Decimo C Chiamulera Source Type: research