Insular and prelimbic cortices control behavioral accuracy and precision in a temporal decision-making task in rats
Behav Brain Res. 2024 Mar 15:114961. doi: 10.1016/j.bbr.2024.114961. Online ahead of print.ABSTRACTThe anterior insular cortex (AIC) comprises a region of sensory integration. It appears to detect salient events in order to guide goal-directed behavior, code tracking errors, and estimate the passage of time. Temporal processing in the AIC may be instantiated by the integration of representations of interoception. Projections between the AIC and the medial prefrontal cortex (mPFC) - found both in rats and humans - also suggest a possible role for these structures in the integration of autonomic responses during ongoing beha...
Source: Behavioural Brain Research - March 17, 2024 Category: Neurology Authors: Estela B Nepomoceno Samanta Rodrigues Katia S de Melo Tatiana L Ferreira David Freestone Marcelo S Caetano Source Type: research

Assessment of rTMS treatment effects for methamphetamine use disorder based on EEG microstates
This study included a comprehensive subject population to investigate the effect of rTMS on MUD microstates. 34 patients with MUD underwent a 4-week randomized, double-blind rTMS intervention (active=17, sham=17). Two resting-state EEG recordings and VAS evaluations were conducted before and after the intervention period. Additionally, 17 healthy individuals were included as baseline controls. The modified k-means clustering method was used to calculate four microstates (MS-A~MS-D) of EEG, and the FC network was also analyzed. The differences in microstate indicators between groups and within groups were compared. The dura...
Source: Behavioural Brain Research - March 17, 2024 Category: Neurology Authors: Yongcong Li Banghua Yang Jun Ma Shouwei Gao Hui Zeng Wen Wang Source Type: research

CK2 negatively regulates the extinction of remote fear memory
In this study, we adopted a classical Pavlovian fear conditioning model to investigate the involvement of CK2 in remote fear memory extinction and its underlying mechanisms. The results indicated that the activity of CK2 in the medial prefrontal cortex (mPFC) of mice was significantly upregulated after extinction training of remote cued fear memory. Notably, administration of the CK2 inhibitor CX-4945 prior to extinction training facilitated the extinction of remote fear memory. In addition, CX-4945 significantly upregulated the expression of p-ERK1/2 and p-CREB in the mPFC. Our results suggest that CK2 negatively regulate...
Source: Behavioural Brain Research - March 17, 2024 Category: Neurology Authors: Jie Yang Lin Lin Guang-Jing Zou Lai-Fa Wang Fang Li Chang-Qi Li Yan-Hui Cui Fu-Lian Huang Source Type: research

Prefrontal activity during iowa gambling task in young adult women
This study aims to investigate the relationships between personality traits of impulsivity, using the UPPS-P Impulsive Behaviour Scales shortened version, and prefrontal cortex (PFC) activity during the IOWA Gambling Task (IGT) in young adult women. The study included a sample of 83 young, healthy females (19.8 ± 1.4 years), who voluntarily took part in the study. Repeated measures analysis during the IGT revealed a significant increase in HbO (all p <.001; ηp2 >.31) and a decrease in Hbr (all p <.003; ηp2 >.08) in all prefrontal quadrants. This increase in oxygenation occurs primarily during the choice peri...
Source: Behavioural Brain Research - March 15, 2024 Category: Neurology Authors: Ferran Balada Anton Aluja Oscar Garc ía Neus Aymam í Luis F Garc ía Source Type: research

Prefrontal activity during iowa gambling task in young adult women
This study aims to investigate the relationships between personality traits of impulsivity, using the UPPS-P Impulsive Behaviour Scales shortened version, and prefrontal cortex (PFC) activity during the IOWA Gambling Task (IGT) in young adult women. The study included a sample of 83 young, healthy females (19.8 ± 1.4 years), who voluntarily took part in the study. Repeated measures analysis during the IGT revealed a significant increase in HbO (all p <.001; ηp2 >.31) and a decrease in Hbr (all p <.003; ηp2 >.08) in all prefrontal quadrants. This increase in oxygenation occurs primarily during the choice peri...
Source: Behavioural Brain Research - March 15, 2024 Category: Neurology Authors: Ferran Balada Anton Aluja Oscar Garc ía Neus Aymam í Luis F Garc ía Source Type: research

The role of lateral hypothalamic nucleus in mediating locomotive behaviors in pigeons (Columba livia)
Behav Brain Res. 2024 Mar 12:114958. doi: 10.1016/j.bbr.2024.114958. Online ahead of print.ABSTRACTThe lateral hypothalamic nucleus (LHy) is located in the dorsolateral hypothalamus of birds, and it is essential to many life processes. However, limited information is available about the role of LHy in mediating locomotive behaviors. In this work, we investigated the structure and function of LHy in pigeons (Columba livia) by Nissl staining, immunohistochemical (IHC) staining, insituhybridization (ISH) staining and constant current stimulation methods. The results showed that LHy appears crescent in shape, and three-dimensi...
Source: Behavioural Brain Research - March 14, 2024 Category: Neurology Authors: Xinmao Tian Zishi Wang Yuhua Shi Chongchong Jia Xiujuan Li Mengke Li Haowei Liu Zhenlong Wang Source Type: research

The role of lateral hypothalamic nucleus in mediating locomotive behaviors in pigeons (Columba livia)
Behav Brain Res. 2024 Mar 12:114958. doi: 10.1016/j.bbr.2024.114958. Online ahead of print.ABSTRACTThe lateral hypothalamic nucleus (LHy) is located in the dorsolateral hypothalamus of birds, and it is essential to many life processes. However, limited information is available about the role of LHy in mediating locomotive behaviors. In this work, we investigated the structure and function of LHy in pigeons (Columba livia) by Nissl staining, immunohistochemical (IHC) staining, insituhybridization (ISH) staining and constant current stimulation methods. The results showed that LHy appears crescent in shape, and three-dimensi...
Source: Behavioural Brain Research - March 14, 2024 Category: Neurology Authors: Xinmao Tian Zishi Wang Yuhua Shi Chongchong Jia Xiujuan Li Mengke Li Haowei Liu Zhenlong Wang Source Type: research

One-trial odour recognition learning and its underlying brain areas in the zebrafish
Behav Brain Res. 2024 Mar 11:114949. doi: 10.1016/j.bbr.2024.114949. Online ahead of print.ABSTRACTDistinguishing familiar from novel stimuli is critical in many animals' activities, and procedures based on this ability are among the most exploited in translational research in rodents. However, recognition learning and the underlying brain substrates remain unclear outside a few mammalian species. Here, we investigated one-trial recognition learning for olfactory stimuli in a teleost fish using a behavioural and molecular approach. With our behavioural analysis, we found that zebrafish can learn to recognise a novel odour ...
Source: Behavioural Brain Research - March 13, 2024 Category: Neurology Authors: Tyrone Lucon-Xiccato Gaia De Russi Elena Frigato Marco Dadda Cristiano Bertolucci Source Type: research

Neuroprotective effects of platinum nanoparticle-based microreactors in bicuculline-induced seizures
This study investigates the in vivo effects of these microreactors in an animal model of epilepsy induced by the administration of the GABAergic antagonist bicuculline. Male Wistar rats were administered intracerebroventricularly (i.c.v.) with the microreactors or saline and, five days later, injected with bicuculline or saline. Seizure severity was evaluated in an open field. Thirty min after behavioral measurements, animals were euthanized, and their brains processed for neurodegeneration evaluation and for neurogenesis. Treatment with the microreactors significantly increased the time taken for the onset of seizures and...
Source: Behavioural Brain Research - March 13, 2024 Category: Neurology Authors: Roberto N Oliveira Patr ícia S Carvalhinho-Lopes Carolina P F Carvalho Rafael Y S Hirata Sandra H Vaz Ana Maria Sebasti ão Adam Armada-Moreira B árbara A Rosário J éssica A Lemes Beatriz Soares-Silva Jos é S de Andrade Jos é Ronaldo Santos Alessand Source Type: research

Chronic MK-801 administration provokes persistent deficits in social memory in the prairie vole (Microtus ochrogaster): a potential animal model for social deficits of schizophrenia
Behav Brain Res. 2024 Mar 11:114948. doi: 10.1016/j.bbr.2024.114948. Online ahead of print.ABSTRACTThe prairie vole (Microtus ochrogaster) is a rodent species that has been used extensively to study biological aspects of human social bonding. Nevertheless, this species has not been studied in the context of modeling social deficits characteristic of schizophrenia. Building on studies in rodents that show that sub-chronic administration of an NMDA receptor antagonist induces persistent behavioral and neurological characteristics of schizophrenia, we administered MK-801 (0.2mg/kg, daily, for 7 days) or physiological saline t...
Source: Behavioural Brain Research - March 13, 2024 Category: Neurology Authors: Enrique Basurto Oscar Gonz ález-Flores Kurt Hoffman Source Type: research

Neural correlates of inhibitory control in the context of infant cry and paternal postpartum mental health
CONCLUSION: This study is the first to underscore the complex interplay between the neural mechanisms related to inhibitory control and postpartum mental health and stress across varied auditory context, laying the groundwork for future research.PMID:38460795 | DOI:10.1016/j.bbr.2024.114947 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 9, 2024 Category: Neurology Authors: Yael Waizman Ellen Herschel Sofia I C árdenas Anthony G Vaccaro Elizabeth C Aviv Pia E Sellery Diane Goldenberg Jonas Kaplan Darby E Saxbe Source Type: research

Neural Correlates of Inhibitory Control in the Context of Infant Cry and Paternal Postpartum Mental Health
CONCLUSION: This study is the first to underscore the complex interplay between the neural mechanisms related to inhibitory control and postpartum mental health and stress across varied auditory context, laying the groundwork for future research.PMID:38460795 | DOI:10.1016/j.bbr.2024.114947 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 9, 2024 Category: Neurology Authors: Yael Waizman Ellen Herschel Sofia I C árdenas Anthony G Vaccaro Elizabeth C Aviv Pia E Sellery Diane Goldenberg Jonas Kaplan Darby E Saxbe Source Type: research

Neural Correlates of Inhibitory Control in the Context of Infant Cry and Paternal Postpartum Mental Health
CONCLUSION: This study is the first to underscore the complex interplay between the neural mechanisms related to inhibitory control and postpartum mental health and stress across varied auditory context, laying the groundwork for future research.PMID:38460795 | DOI:10.1016/j.bbr.2024.114947 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 9, 2024 Category: Neurology Authors: Yael Waizman Ellen Herschel Sofia I C árdenas Anthony G Vaccaro Elizabeth C Aviv Pia E Sellery Diane Goldenberg Jonas Kaplan Darby E Saxbe Source Type: research

Neural Correlates of Inhibitory Control in the Context of Infant Cry and Paternal Postpartum Mental Health
CONCLUSION: This study is the first to underscore the complex interplay between the neural mechanisms related to inhibitory control and postpartum mental health and stress across varied auditory context, laying the groundwork for future research.PMID:38460795 | DOI:10.1016/j.bbr.2024.114947 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 9, 2024 Category: Neurology Authors: Yael Waizman Ellen Herschel Sofia I C árdenas Anthony G Vaccaro Elizabeth C Aviv Pia E Sellery Diane Goldenberg Jonas Kaplan Darby E Saxbe Source Type: research

The cerebellum and its connections to other brain structures involved in motor and non-motor functions: a comprehensive review
Behav Brain Res. 2024 Mar 6:114933. doi: 10.1016/j.bbr.2024.114933. Online ahead of print.ABSTRACTThe cerebellum has a large network of neurons that communicate with several brain structures and participate in different functions. Recent studies have demonstrated that the cerebellum is not only associated with motor functions but also participates in several non-motor functions. It is suggested that the cerebellum can modulate behavior through many connections with different nervous system structures in motor, sensory, cognitive, autonomic, and emotional processes. Recently, a growing number of clinical and experimental st...
Source: Behavioural Brain Research - March 8, 2024 Category: Neurology Authors: Jos é Mário Prati Andr é Pontes-Silva Anna Carolyna Lepesteur Gianloren ço Source Type: research