Treatment patterns in UK adult patients with atopic dermatitis treated with systemic immunosuppressants: data from The Health Improvement Network (THIN).
Conclusions: The prevalence of comorbidities and high rate of IMM prescriptions demonstrate the impact of AD on quality of life. The frequency of OCS prescribing in AD patients treated with IMMs suggests a lack of disease control with existing therapies, and an unmet need for safe and effective targeted agents for long-term disease control. PMID: 31305182 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 16, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Guselkumab improves work productivity in patients with moderate-to-severe psoriasis with or without depression and anxiety: results from the VOYAGE 2 comparator study versus adalimumab.
Authors: Reich K, Foley P, Han C, McElligott S, Muser E, Li N, Armstrong AW Abstract Purpose: To evaluate the impact of guselkumab on work productivity, including absenteeism and presenteeism, in psoriasis patients with and without depression/anxiety. Methods: VOYAGE 2 is a randomized, double-blind, placebo-controlled, and comparator-controlled, phase 3 trial that compared guselkumab with adalimumab in patients with moderate-to-severe psoriasis. Absenteeism was evaluated among patients who reported that their skin prevented work/study based on the Dermatology Life Quality Index (DLQI) work/study domain (score = 3) ...
Source: Journal of Dermatological Treatment - July 16, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Radiation for below the knee skin cancers: a single institution experience.
Conclusions: For patients not eligible for surgery, radiation therapy is an option with a moderate chance of complete response (65%) and a 17% risk of poor wound healing/radiation necrosis. PMID: 31294616 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Mycophenolate mofetil and atopic dermatitis: systematic review and meta-analysis.
Conclusions: In summary, the current evidence to date is low-quality in nature but is promising regarding the efficacy and safety of MMF for adult and paediatric atopic dermatitis. There should be ongoing monitoring for infections that may develop on long term therapy. PMID: 31294617 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Immunomodulatory effects of topical diphencyprone for the treatment of acute urban cutaneous leishmaniasis.
This study investigates the efficacy of adding diphencyprone immunotherapy to conventional meglumine antimoniate (MA) treatment for acute urban CL. Methods: This randomized controlled pilot study included 46 patients with acute CL. They were randomly allocated to receive either combination of diphencyprone immunotherapy with intralesional MA (intervention; N = 23) or intralesional MA alone (control; N = 23) weekly. The size and duration of lesions were measured at the baseline and after that at 4th, 8th, 12th, and 24th weeks. Data were analyzed in SPSS and P 
Source: Journal of Dermatological Treatment - July 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Difference in Vasoconstrictors: Oxymetazoline vs Brimonidine.
CONCLUSION: Topical oxymetazoline and brimonidine are effective for the management of persistent facial erythema associated with rosacea with a few mild and localized adverse effects. Further long term research is imperative to further understand their long term effects. PMID: 31294643 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of imiquimod 5% cream for basal cell carcinoma: a meta-analysis of randomized controlled trial.
Conclusion: The present meta-analysis indicated the effects of imiquimod in improving the histological/composite clearance rates as compared with other treatments. PMID: 31294669 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dose-response association between vitamin D deficiency and atopic dermatitis in children, and effect modification by gender: A case-control study.
Authors: Ahmed Mohamed A, Salah Ahmed EM, Farag YM, Bedair NI, Nassar NA, Ghanem AIM Abstract Background: Vitamin D is a regulatory factor for immunity and skin barrier functions. It is hypothesized to be linked to atopic dermatitis (AD) which is characterized by interaction between epidermal barrier dysfunction and dysregulation of skin immune functions. Methods: One hundred AD patients and one hundred and one normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of 25-hydroxyvitamin D [25(OH)D]. We assessed the relationship between 25(OH)D deficiency and AD ...
Source: Journal of Dermatological Treatment - July 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Omalizumab in complex conditions: when urticaria is associated with other diseases and safety may be a challenge.
Authors: Cancian M PMID: 31282779 [PubMed] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Characterization of responder groups to secukinumab treatment in moderate to severe plaque psoriasis.
Conclusions: Baseline factors, including weight and cardiometabolic status, were associated with response to secukinumab. Early onset of response may indicate treatment efficacy later on. PMID: 31287332 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Experiences of barbed polydioxanone (pdo) cog thread for facial rejuvenation and our technique to prevent thread migration.
Conclusion: Our results revealed barbed PDO cog thread is highly effective in facial rejuvenation. Also, tying the PDO threads in same entry point to each other seems to be an effective technique to prevent thread migration. PMID: 31267809 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 5, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Sustained and Continuously Improved Efficacy of Tildrakizumab in Patients with Moderate-to-Severe Plaque Psoriasis.
Conclusions: Most tildrakizumab-treated patients with week-28 PASI ≥75 maintained their week-28 PASI improvement at week 52. More than half of week-28 partial responders (PASI 50-74) improved their PASI responses to PASI ≥75 at week 52. Clinicaltrials.gov Identifiers: NCT01722331, NCT01729754. PMID: 31268369 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 5, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluating and Reducing Xerosis in Competitive Swimmers: An In Vitro Study and Randomized Controlled Clinical Trial.
CONCLUSIONS: Artificial skin preservation varied for five commercially available moisture barriers. Moisture barrier application improved moisture content and reduced xerosis in competitive swimmers. PMID: 31257951 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patients' knowledge about psoriasis and comorbidities; their participation in treatment decisions.
Conclusion: The results of this study showed that majority of patients with psoriasis are not aware of the increased risk of comorbid diseases and do not have enough knowledge about psoriasis. PMID: 31257954 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Crystallized phenol for sacral hidradenitis suppurativa.
Conclusion: CPT may be useful as a first-line treatment of sacral HS. PMID: 31259621 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Sea Urchin Injuries: A review and clinical approach algorithm.
Authors: Schwartz Z, Cohen M, Lipner SR Abstract Sea urchin injuries are among the most common marine injuries, however, there are no guidelines to dictate appropriate workup and treatment. Complications vary significantly depending on the extent of injury, site of injury and elapsed time to medical attention. Timely and appropriate management can prevent long term morbidity despite the deceptively innocuous appearance of these injuries. We review the English literature on sea urchin injuries and offer an algorithm to aid in the management of affected patients. We found that superficially retained spines may trigge...
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Cannabinoids for the treatment of chronic refractory pruritus.
Authors: Khanna R, Khanna R, Denny G, Kwatra SG PMID: 31264498 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A revisit to the effects of zinc salt on skin burn wound healing to reflect the risks in current pharmaceutical care.
This study examined skin wound healing process of rats inflicted by partial thickness thermal burn wound as a function of applied soluble zinc contents (0.1 ml of zinc chloride solution 0.01% (w/w) or 5.0% (w/w)). The size, surface morphology and histological profiles of wound beds of untreated rats and those treated with zinc chloride solutions were characterized. A soluble zinc content as low as 10.5 μg/cm2 of skin negated skin wound healing when compared to the untreated rats. This was alarming as the commercial products currently in the market are formulated with a high level of zinc content. Albeit th...
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ.
Conclusions: For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS due to its tissue-preserving nature particularly in the head and neck region. Key points Our adjusted analysis demonstrates similar overall and cancer-specific survival for Mohs surgery vs wide local excision for head and neck melanoma-in-situ For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS This is due to its tissue-preserving nature particularly in the head and neck region. PMID: 31264932 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient and physician preferences for atopic dermatitis injection treatments in Japan.
Conclusion: Overall patients and physicians differ in their preferences for AD treatments. These findings have implications for shared decision making and clinical practice. PMID: 31250681 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 30, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of Run Zao Zhi Yang capsule on chronic eczema: a multiple-center, randomized, double-blind, placebo-controlled clinical study.
Authors: Huang D, Chen K, Zhang FR, Yang S, Guo Q, Xu JH, Li H, Tan GZ, Yang BQ, Lu QJ, Zheng J, Li LF, Gu H Abstract Background: Run Zao Zhi Yang capsule (RZZYC) has been widely applied for eczema treatment as a traditional Chinese medicine, while its efficacy has not been scientifically investigated. Objective: We conducted this multiple-centers, randomized, double-blind, placebo-controlled study to investigate the effectiveness and safety of RZZYC on the treatment of patients with mild to moderate chronic eczema. Methods: 240 patients were randomly assigned into the experimental group and the placebo group. The ...
Source: Journal of Dermatological Treatment - June 22, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dermocosmetics: beneficial adjuncts in the treatment of acne vulgaris.
Discussion: The different types of active ingredients in dermocosmetics for acne can be classified as: sebum-controlling, antimicrobial, anti-inflammatory, anti-oxidant and/or keratolytic. Such agents may modulate the pathogenic pathways in acne. Dermocosmetics can be formulated as emulsions/creams, cleansers or camouflaging make-up. Dermocosmetics are useful treatment adjuncts for acne and have been shown to improve the clinical signs of acne, reduce transepidermal water loss and modify sebum production. Dermocosmetics have also been associated with reducing side effects of pharmacological treatments, high levels of patie...
Source: Journal of Dermatological Treatment - June 19, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The efficacy and safety of BM-PHA for the correction of nasolabial folds: a multicenter, randomized, double-blind, split-face clinical trial.
Conclusion: BM-PHA was not inferior to PER in the treatment of moderate to severe nasolabial folds and may be an appropriate alternative product for their improvement. Further studies are needed to confirm the long-term safety of BM-PHA. PMID: 31195857 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 16, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

An Evidence-Based Evaluation of Disclosure.
Authors: Chea EP, Unrue EL, Cline AE, Feldman SR PMID: 31195911 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 16, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Antibiotics for acne vulgaris: using Instagram to seek insight into the patient perspective.
Conclusions: Instagram may have utility in elucidating patient behavior and attitudes. Dermatologists should increase their social media presence in order to disqualify any incorrect information endorsed in 'popular' or commonly viewed posts. PMID: 31190574 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 15, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Checkmark rotation flap for nasal tip reconstruction in Asian patients.
Conclusion: CRF may be a favorable option for the reconstruction of intermediate-sized nasal tip defects, providing good cosmetic outcomes. PMID: 31184519 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of Acrodermatitis continua of Hallopeau with Ixekizumab.
We present a patient with ACH resistant to multiple therapies, including the biologic adalimumab, who was successfully treated with an IL-17 inhibitor (Ixekizumab). We believe our unique treatment with an excellent outcome may assist other dermatologists if faced with this condition. PMID: 31184530 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison of Intralesional Triamcinolone Acetonide, Botulinum toxin type A, and Their Combination for the Treatment of Keloid lesions.
Conclusion: Combined injection of intralesional steroids with BTX-A appears to be superior to either therapy alone and offer the best benefit of safer and more efficacious response with lesser side effects. PMID: 31184533 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study.
Conclusions: The oral mucoadhesive film containing chitosan promotes oral ulcer healing and can be used as a drug carrier in treating oral ulcers. Trial registration number: ChiCTR-IOR-16008970. PMID: 31179773 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Low-dose Total Skin Electron Beam Therapy for Refractory Cutaneous CD30 Positive Lymphoproliferative Disorders.
We describe a case of a 48-year-old woman with a refractory cutaneous CD30 positive lymphoproliferative disorder treated successfully with total skin electron beam radiotherapy (TSEBT). PMID: 31179774 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Modified Mercedes flap - an effective reconstructive option for lower leg skin defects.
Authors: Tampouratzi E, Kanni T, Katsantonis J, Douvali T PMID: 31179785 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2.
Authors: Cork MJ, Eckert L, Simpson EL, Armstrong A, Barbarot S, Puig L, Girolomoni G, de Bruin-Weller M, Wollenberg A, Kataoka Y, Remitz A, Beissert S, Mastey V, Ardeleanu M, Chen Z, Gadkari A, Chao J Abstract Background: Atopic dermatitis (AD) profoundly affects quality of life (QoL). Dupilumab significantly improves clinical outcomes, is well tolerated, and approved to treat inadequately controlled moderate-to-severe AD in adults; however, its effect on patient-reported outcomes (PROs) is not fully characterized. Objective: To evaluate the impact of dupilumab on patient-reported AD symptoms and QoL. Methods: Poo...
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Adiponectin levels in a large pooled plaque psoriasis study population.
Authors: Gerdes S, Pinter A, Biermann M, Papavassilis C, Reinhardt M Abstract Background: Adiponectin is an adipocyte-secreted protein potentially relevant in the context of cardiometabolic comorbidity of psoriasis patients. Objective: This post-hoc analysis aimed to assess the impact of obesity, metabolic syndrome, psoriasis severity and treatment with secukinumab/etanercept on adiponectin. Methods: Three phase III trials in moderate to severe plaque psoriasis were included. Correlations of Psoriasis Area and Severity Index (PASI), body mass index (BMI), and associated comorbidity with adiponectin levels as well a...
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of Stem cell-conditioned medium vs Platelet-rich plasma as an adjuvant to post-ablative fractional CO2 laser resurfacing for atrophic post-acne scars: a split-face clinical trial.
Conclusion: Topical SC-CM could potentially enhance the efficacy of FCL. However, PRP seems to be a better alternative. PMID: 31180258 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Defining the Role of Mirtazapine in the Treatment of Refractory Pruritus.
Authors: Fawaz B, Chamseddin BH, Griffin JR Abstract Mirtazapine has traditionally been used for the treatment of major depressive disorder, with an added benefit in patients who have comorbid insomnia or anxiety. Recent studies describe its usefulness in treating refractory pruritus of various causes as well. Our goal is to better define the use of mirtazapine in the treatment of refractory pruritus. Through a thorough literature review, we identified all reports of the use of mirtazapine for pruritus. We found that mirtazapine has quality evidence for the treatment of intra-thecal morphine-induced pruritus. Mirta...
Source: Journal of Dermatological Treatment - June 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Objective analysis of volume restoration in atrophic acne scars and skin pores: A split study using human stem cell-conditioned media.
In conclusion, HSCM may augment the regenerative effects of fractional CO2 laser. PMID: 31172821 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 9, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Real life practice: rapid improvement in itch symptomatology in patients with atopic dermatitis treated with dupilumab.
We report the extraordinary response to the pruritic symptomatology and, the consequent improvement of quality of life, that occurs already after 4 weeks of therapy. PMID: 31172841 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 9, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

CO2 laser treatment of a kissing nevus of the penis: an alternative solution for a rare condition.
We report a case of a penile kissing nevus with its dermoscopic and histopathological characteristics as well as its successful treatment with the carbon dioxide (CO2) laser. PMID: 31173504 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 9, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rosacea Fulminans: two case reports and review of the literature.
We report two cases of Rosacea Fulminans arised in otherwise healthy people and completely healed after treatment. Our aim is to share our experience about this disease in order to increase knowledge about its diagnosis, management and its treatment. We also make a review of the literature of this peculiar dermatosis. PMID: 31169436 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 8, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combined long pulsed Nd-Yag laser and Itraconazole versus Itraconazole alone in the treatment of Onychomycosis nails.
CONCLUSIONS: The use of combined long pulsed Nd-Yag laser and itraconazole pulse therapy gives the best clinical results and patient's satisfaction. PMID: 31157575 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 5, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Development of the Psoriasis Symptoms Scale (PSS) in patients with moderate-to-severe psoriasis: qualitative and quantitative analyses.
Authors: Armstrong AW, Edson-Heredia E, Naegeli AN, Burge R, Poon JL, Anatchkova M, Sun L, Zhu B, Wyrwich KW Abstract Background: Psoriasis is a chronic inflammatory skin disease. Objective: To establish content validity and assess psychometric properties of the Psoriasis Symptoms Scale (PSS) in patients with moderate-to-severe psoriasis (Ps). Methods: The PSS is an 8-item patient-completed questionnaire assessing symptoms (itch, pain, stinging, burning), signs (redness, scaling, cracking), and discomfort. Content validity was established during interviews of patients (n = 14) with Ps. PSS Symptoms an...
Source: Journal of Dermatological Treatment - June 5, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of combined treatment with long-pulsed neodymium-doped yttrium aluminum garnet laser and potassium hydroxide for the treatment of recalcitrant wart: a prospective comparative study.
This study aimed to evaluate combined treatment with LP Nd:YAG laser and KoH for the treatment of recalcitrant wart. Methods: This study included 132 lesions from 38 patients. Long-pulsed (LP) Nd:YAG laser was applied to 66 lesions with daily 10% KOH application at night, and the remaining 66 lesions underwent LP Nd:YAG laser therapy only. Results: Both groups showed statistically significant regressions in the size of the lesions at the end of the fifth session compared with those present at the onset of therapy (p 
Source: Journal of Dermatological Treatment - May 30, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Review of international psoriasis guidelines for the treatment of psoriasis: recommendations for topical corticosteroid treatments.
Authors: Kleyn EC, Morsman E, Griffin L, Wu JJ, Cm van de Kerkhof P, Gulliver W, van der Walt JM, Iversen L PMID: 31138038 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 30, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Embracing machine learning and digital health technology for precision dermatology.
Authors: Wongvibulsin S, Ho BK, Kwatra S PMID: 31122081 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 29, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Antibiotic Prescribing Trends Among US Dermatologists in Medicare From 2013-2016.
Conclusions: Between 2013 - 2016, the number of oral antibiotics prescribed by dermatologists has increased among Medicare patients. Dermatologists must continue to re-evaluate antibiotic prescription practices, particularly among the elderly population, in order to provide optimal care to patients. PMID: 31122085 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 29, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Improving psoriasis patients' adherence to topical drugs: A systematic review.
Conclusion: There is a need to develop better adherence-improving interventions. A good patient-healthcare provider relationship is considered crucial to adherence and may be an important intervention target. Before interventions to improve adherence to topicals can be recommended for the clinic, the intervention should be tested in high-quality RCTs. PMID: 31122090 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 29, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is topical treatment effective for psoriasis in patients who failed topical treatment?
Conclusions: While our sample size was small and treatment duration short, the effect size of topical treatment was large under conditions designed to promote adherence. PMID: 31132897 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 29, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rosacea Associated with Dupilumab Therapy.
Conclusion: The cause of rosacea-like reaction associated with dupilumab treatment is unknown. Th2 pathway inhibition by dupilumab may promote Demodex proliferation and increased IL-17-mediated inflammation implicated in the pathophysiology of rosacea. PMID: 31132923 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 29, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of Pioglitazone for treatment of plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials.
Authors: Chang G, Wang J, Song J, Zhang Z, Zhang L Abstract Background A growing number of studies have shown that thiazolidinedoniones(TZD) can be antipsoriatic. Pioglitazone is a representative of the class of antidiabetic drugs known as TZD. TZD can activate nuclear peroxisome proliferator-activated receptors (PPAR)-c. PPARs are expressed on epidermal keratinocytes and exert their effects by promoting the terminal differentiation of keratinocytes, inhibiting epidermal growth, and reducing inflammatory responses. These observations suggest that TZD have potential benefits in the treatment of cutaneous and metabol...
Source: Journal of Dermatological Treatment - May 24, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dermatofibrosarcoma Protuberans: Our 10-year experience on 80 Patients.
Conclusion: Clean margin of excision should be achieved to prevent recurrence of DFSP. Slow Mohs surgery is recommended to treat DFSP. PMID: 31116621 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 24, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research