Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice

In this study, we investigated the function of UBIAD1 in osteogenesis using a tamoxifen-dependent UBIAD1-deficient mouse model. When UBIAD1 deficiency was induced from the first week of life, the femur was significantly shortened, and bone mineral density (BMD) was reduced. In addition, the expression of bone and chondrocyte matrix proteins and chondrocyte differentiation factors was significantly decreased. In primary cultured chondrocytes, chondrocyte differentiation was significantly reduced by UBIAD1 deficiency. These results suggest that UBIAD1 is an important factor for the regulation of chondrocyte proliferation and differentiation during osteogenesis.PMID:38335702 | DOI:10.1016/j.bbrc.2024.149635
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research