Recent advances in the borylative transformation of carbonyl and carboxyl compounds
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01029G, Review ArticleZeyu He, Yue Hu, Chungu Xia, Chao Liu The recent advances in the borylative transformation of carbonyl and carboxyl compounds are summarized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Zeyu He Source Type: research

A NIR fluorescent probe for detection of viscosity and lysosome imaging in live cells
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01222B, PaperTong Chen, Zikang Chen, Ruiyuan Liu, Shaobing Zheng A D –π-A structure near-infrared fluorescent probe (Lyso-BTC) is explored for its fluorescence visualization and detection of lysosomes in view of a large Stokes shift (∼190 nm), NIR emission (685 nm), excellent photostability, fluorescence response to viscosity, and lysosome-targeted property. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Tong Chen Source Type: research

Transition-metal free oxidative C –H etherification of acylanilines with alcohols through a radical pathway
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01224A, CommunicationXiaobo Xu, Zhengzhou Chu, Chengcai Xia Synthesis of methyl/ethyl aryl ethervia oxidative C –H etherification of acylanilines with alcohols under transition-metal-free conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Xiaobo Xu Source Type: research

Diastereoselective synthesis of -dicarbonyl cyclopropanes via a lanthanide amide-catalysed reaction
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00732F, PaperWenxi Sun, Cheng Peng, Zhigang Yao, Fan Xu Lanthanide bis(trimethylsilyl)amides, [(Me3Si)2N]3Ln( μ-Cl)Li(THF)3, were used as efficient catalysts for a one-pot reaction of α-ketoesters, dialkyl phosphite, and activated alkenes to produce -dicarbonyl cyclopropanes in moderate to high yields. The reaction... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Wenxi Sun Source Type: research

Simple and Direct Dehydrogenative C(sp3) –H Bond Functionalization of Tetrahydroisoquinolines Mediated by Organic Oxidants under Mild Conditions
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01090D, PaperZdravko Dzambaski, Bojan Bond žić Organocatalyzed Mannich reaction of unsubstituted and N-Aryl-substituted tetrahydroisoquinolines (THIQs) and Strecker reaction of several N-Aryl-substituted THIQs through dehydrogenative sp3 C −H bond functionalization (Cross dehydrogenative coupling) promoted by organic singleelectron oxidants... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Zdravko Dzambaski Source Type: research

Organocatalytic Asymmetric Synthesis of Dihydrofuran-Spirooxindoles from Benzylidene Malononitriles and Dioxindoles
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01199D, CommunicationSubhas Chandra Pan, Megha Balha, Buddhadeb Mondal The first organocatalytic enantioselective synthesis of dihydrofuran-spirooxindoles having linkage at 2-position of dihydrofuran motif has been developed. Dioxindoles and benzylidene malononitriles were employed in this method. The desired spirooxindole products... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Subhas Chandra Pan Source Type: research

Amine-Tethered Phenylboronic Acid-Enabling Ring-Opening Strategy for Carbon Chain Elongation from Double Aldol Cyclic Hemiacetals
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01263J, CommunicationYamato Kanzaki, Yuki Hirao, Harunobu Mitsunuma, Motomu Kanai The addition of carbon nucleophiles to cyclic hemiacetal forms of double aldols is a promising approach toward the synthesis of structurally attractive 1,3-polyol derivatives. Cyclic hemiacetals are generally unreactive to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Yamato Kanzaki Source Type: research

Push –pull isomers of indolizino[6,5,4,3-def]phenanthridine decorated with a triarylboron moiety
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00923J, PaperLei Dong, Felix Saraci, Kang Yuan, Xiang Wang, Suning Wang Push –pull regioisomers decorated with a triarylboron unit and an electron-withdrawing aryl ring based on an unsymmetrical indolizino[6,5,4,3-def]phenanthridine backbone have been found to display distinct temperature “turn-on” fluorescence. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Lei Dong Source Type: research

Recent advances and applications of p-toluenesulfonylmethyl isocyanide (TosMIC)
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00847K, Review ArticleArun Divakar Mathiyazhagan, Gopinathan Anilkumar TosMIC (p-toluenesulfonylmethyl isocyanide) was recognised as an important building block in organic synthesis since it was introduced in 1972 and a wide range of reaction strategies have been reported till... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Arun Divakar Mathiyazhagan Source Type: research

Organocatalytic [4+2] Cyclizations of para-Quinone Methide Derivatives with Isocyanates
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00918C, PaperYu-Chun Cheng, Cong-Shuai Wang, Tian-Zhen Li , Feng Gao, Yinchun Jiao, Feng Shi The first [4+2] cyclizations of para-quinone methide derivatives with isocyanates have been established under the catalysis of Br ønsted acid or Brønsted base, which efficiently constructed benzoxazin-2-one frameworks in generally high... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Yu-Chun Cheng Source Type: research

Thermal and photochemical annulation of vinyl azides to 2-aminoimidazoles
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01100E, CommunicationLucas Man, Royston Copley, Anthony L Handlon 2-Aminoimidazoles represent useful synthons for incorporation into medicinal compounds. They provide hydrogen bonding loci, water solubilizing properties and convenient handles for further synthetic elaboration. The rapid and facile generation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Lucas Man Source Type: research

Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H-1H coupling constants
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01139K, PaperKrist ýna Cagašová, Maryam Ghavami, Zhong-Ke Yao, Paul R Carlier The Pictet-Spengler reaction of tryptophan esters and aldehydes has been widely applied in natural products synthesis and medicinal chemistry. To date, the trans- or cis-configuration of 1,3-disubstituted tetrahydro- β-carbolines (THβCs) formed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Krist ýna Cagašová Source Type: research

Iodine catalysed transfer hydrogenation of carbon-carbon σ-bond with water
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01241A, CommunicationYang Wu, Ching Tat To, Kin Shing Chan Iodine catalysed the transfer hydrogenation of benzylic C –C σ-bond in [2.2]paracyclophane with water to yield 4,4’-dimethylbibenzyl. The C-C -bond was first cleaved by the homolytic substitution with iodine radical to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2019 Category: Molecular Biology Authors: Yang Wu Source Type: research

Full Solid-Phase Total Synthesis of Macrocyclic Natural Peptides Using Four-Dimensionally Orthogonal Protective Groups
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01130G, Review ArticleHiroaki Itoh, Masayuki Inoue Fmoc-based solid-phase synthesis provides efficient access to both linear and macrocyclic peptides. To synthesize complex macrocyclic polyamides using Fmoc chemistry, multiple protective groups with orthogonal reactivities are generally employed because... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2019 Category: Molecular Biology Authors: Hiroaki Itoh Source Type: research

A facile construction of oxygen heterocycles by the reaction of benzoxepine-4-carboxylates with dihaloalkanes and activated alkynes
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00769E, PaperVeera Prasad Kasagani, Siva Hariprasad Kurma, China Raju Bhimapaka This manuscript describes the preparation of heterocyclic compounds such as naphtho[1,3]-dioxoles (3a-h), [1,4]-dioxines (4a-h), [1,4]-dioxepines (5a-c), [1,4]-dioxocines (6a-c) and diethyl 2-(2-ethoxy-2-oxoethyl)naphtho[1,3]dioxoles (8a-f). These heterocyclic compounds have been achieved by the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2019 Category: Molecular Biology Authors: Veera Prasad Kasagani Source Type: research

Iridium-catalyzed asymmetric synthesis of 3,4-dihydro-1H-pyrazino[2,1-b]quinazolin-6(2H)-one derivatives
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01057B, PaperFei Peng, Hua Tian, Pengxiang Zhang, Haijun Yang, Hua Fu An efficient iridium-catalyzed asymmetric synthesis of 3,4-dihydro-1H-pyrazino[2,1-b]quinazolin-6(2H)-one derivatives has been developed, and the corresponding products were obtained in high reactivity and high to excellent enantioselectivity with tolerance of some functional... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2019 Category: Molecular Biology Authors: Fei Peng Source Type: research

Visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01023H, PaperXuezhi Li, Man-Yi Han, Bin Wang, Lei Wang, Min Wang A visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids was developed. In this transformation, the boronic acids could be activated by the organic photocatalyst of Eosin Y, generating the alky... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2019 Category: Molecular Biology Authors: Xuezhi Li Source Type: research

A convenient one-pot synthesis of C(sp2) –C(sp3)-linked 3D-Grid via an ‘A2 + B3’ approach
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00754G, CommunicationYing Wei, Mengcheng Luo, Guang-Wei Zhang, Jia-Qi Lei, Linghai Xie, Wei Huang The synthesis of fluorene-based 3D-Grid-FTPA has been developed by the one-pot formation of six C(sp2)-C(sp3) bonds through BF3 •Et2O-mediated Friedel-Crafts reaction of A2-type DFOH and two B3-type triphenylamines with a total... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2019 Category: Molecular Biology Authors: Ying Wei Source Type: research

Visible-Light Induced Decarboxylative Alkylation of Quinoxalin-2(1H)-ones at C3-position
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01169B, PaperWenxuan Xue, Yingpeng Su, Ke-Hu Wang, Rong Zhang, Yawei Feng, Lindan Cao, Danfeng Huang, Yulai Hu A simple and efficient method for the visible light induced direct carbon alkylation of quinoxalin-2(1H)-ones at C3-position is described. This protocol employs cheap and readily available phenyliodine(III) dicarboxylates as the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Wenxuan Xue Source Type: research

Aryne Insertion into P=O Bond: One-pot Synthesis of Quaternary Phosphonium Triflates
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01157A, PaperPranjal Gogoi, Kashmiri Neog, Dhiraj Dutta, Babulal Das A novel transition-metal free synthetic strategy has been developed for the direct synthesis of quaternary phosphonium triflates via insertion of aryne into phosphine oxide. This methodology provides good yields of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Pranjal Gogoi Source Type: research

Regioselective oxidation of indoles to 2-oxindoles
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00764D, PaperNarshinha Panditrao Argade, Santosh Vasantrao Shelar Facile regioselective oxidation of indoles to 2-oxindoles promoted by sulfuric acid adsorbed on silica gel is reported. The present oxidation strategy is also employed to accomplish total synthesis of natural... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Narshinha Panditrao Argade Source Type: research

Metal-Free Regioselective Direct Thiolation of 2-Pyridones
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01061K, PaperKunita Phakdeeyothin, Sirilata Yotphan A highly regioselective metal-free direct C −H thiolation of 2-pyridones with disulfides/thiols has been developed. A combination of persulfate and a commercially available halide source such as LiCl, NCS or I2... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Kunita Phakdeeyothin Source Type: research

Catalytic Direct Amidations in tert-Butyl Acetate using B(OCH2CF3)3
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Charlotte Coomber, Victor Laserna, Liam Tom Martin, Peter D Smith, Helen Hailes, Michael J Porter, Tom Sheppard Catalytic direct amidation reactions have been the focus of considerable recent research effort, due to the widespread use of amide formation processes in pharmaceutical synthesis. However, the vast majority of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Charlotte Coomber Source Type: research

Synergistic Palladium/Enamine Catalysis for Asymmetric Hydrocarbon Functionalization of Unactivated Alkenes with Ketones
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01165J, PaperChiyu Wei, Xiaohan Ye, Qingyu Xing, Yong Hu, Yan Xie, Xiaodong Shi Synergistic palladium and enamine catalysis were explored to promote ketone addition to unactivated olefin. Secondary amine-based organocatalyst was identified as the optimal co-catalyst for the directed Pd-catalyzed alkene activation. Furthermore,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Chiyu Wei Source Type: research

Copper-Catalysed Borylation of Aryl Chlorides
We report herein the first Cu-catalysed borylation of a wide range of aryl chlorides with different electronic and steric properties using a readily prepared NHC-stabilised Cu catalyst and KOtBu as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Laura Kuehn Source Type: research

Structural flexibility versus rigidity of the aromatic unit of DNA ligands: Binding of aza- and azoniastilbene derivatives to duplex and quadruplex DNA
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Heiko Ihmels, Mohebodin Karbasiyoun , Katharina L öhl, Christopher Stremmel The known azastilbene (E)-1,2-di(quinolin-3-yl)ethane (2a) and the novel azoniostilbene derivatives (E)-2-(2-(naphthalen-2-yl)vinyl)quinolizinium (2b) and (E)-3,3'-(ethane-1,2-diyl)bis(1-methylquinolinin-1-ium) (2c) were synthesized, and their interactions with duplex and quadruplex DNA (G4-DNA) were studied by photometric,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2019 Category: Molecular Biology Authors: Heiko Ihmels Source Type: research

Reversible photo-cross-linking of the GCN4 peptide containing 3-cyanovinylcarbazole amino acid to double-stranded DNA
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00372J, PaperZhiyong Qiu, Shigetaka Nakamura, Kenzo Fujimoto Interaction analysisin vivo greatly promotes the analyses and understanding of biological functions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 13, 2019 Category: Molecular Biology Authors: Zhiyong Qiu Source Type: research

First radiosynthesis of 2-amino-5-[18F]fluoropyridines via a “minimalist” radiofluorination/palladium-catalyzed amination sequence from anisyl(2-bromopyridinyl)iodonium triflate
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01187K, Communicationmathilde pauton, Rapha ël Gillet, catherine aubert, guillaume bluet, Florence Gruss-Leleu, sebastien roy, Cecile Perrio The synthesis of 2-amino-5-[18F]fluoropyridines was achieved in 8-85% yields by palladium-catalyzed reaction of 2-bromo-5-[18F]fluoropyridine with piperidine, dimethylamine, butylamine, methylpiperazine, benzylamine, aniline and 3-aminopyridine. 2-Bromo-5-[18F]fluoropyridine was obtained by radiofluorination of anisyl(2-bromopyridinyl-5)iodonium... The content of this RSS Feed (c) The Royal Society of Chemistry (Sourc...
Source: RSC - Organic and Biomolecular Chemistry - June 13, 2019 Category: Molecular Biology Authors: mathilde pauton Source Type: research

Assessing tether flexibility in the development of hydrocarbon eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) stapled peptides
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01041F, PaperJames M. Song, Erin E. Gallagher, Arya Menon, Lauren D. Mishra, Amanda Lee Garner Hydrocarbon stapled (HCS) peptides are a class of cross-linked alpha-helix mimetics. The technology relies on the use of alpha, alpha ’-disubstituted alkenyl amino acids, which fully contrain the helical region to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 13, 2019 Category: Molecular Biology Authors: James M. Song Source Type: research

The role of conserved arginine in the GH70 family: a computational study of the structural features and their implications on the catalytic mechanism of GTF-SI from Streptoccocus mutans
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01055F, PaperLeslie S ánchez, Fernanda Mendoza, Joel B. Alderete, Verónica A. Jiménez, Gonzalo A. Jaña This manuscript provides novel insights into the structural and mechanistic roles of the conserved residue R475 of GTF-SI, a member of the GH70 family. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Leslie S ánchez Source Type: research

Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01027K, Review ArticleWeidi Cao, Xiaoming Feng, Xiaohua Liu Asymmetric catalysis represents an efficient approach to prepare optically active compounds. Commonly, both enantiomers of a chiral catalyst are used to synthesize two enantiomers of a chiral compound, however, it... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Weidi Cao Source Type: research

Copper-mediated cascade radical cyclization of olefins with naphthalenyl iododifluoromethyl ketones
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00916G, PaperPeng Peng, Guo Zhi Huang, Yingxin Sun, Xing Wang, Jingjing Wu, Fanhong Wu Copper-mediated radical cyclization of naphthalenyl iododifluoromethyl ketones with olefins was successfully developed to generate series of unprecedented gem-difluorodihydrophenanthrenones, especially 2,2-difluoro-3,4-dihydrophenanthren-1(2H)-one derivatives. This strategy features the use of cheap copper powder... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Peng Peng Source Type: research

Total Syntheses of the Bilirubin Oxidation End Product Z-BOX C and its Isomeric Form Z-BOX D
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01117J, PaperDaniel Schulze, Juliane Traber, Marcel Ritter, Helmar G örls, Georg Pohnert, Matthias Westerhausen Oxidative degradation products of bilirubin (BOXes) are biologically highly active. The total synthesis of colorless (Z)-3-(5-(2-amino-2-oxoethylidene)-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)propanoic acid (BOX C, 9) succeeds via a seven-step procedure with a total yield of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Daniel Schulze Source Type: research

Transition-metal free oxidative C-H etherification of acylanilines with alcohols through a radical pathway
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01224A, CommunicationXiaobo Xu, Zhengzhou Chu, Chengcai Xia A transition metal free approach for the synthesis of methyl/ethyl aryl ether via oxidative C-H etherification of acylanilines with alcohols has been developed. Various acylanilines are compatible under standard conditions,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Xiaobo Xu Source Type: research

Facile Synthesis of Chiral ε-Sultams via Organocatalytic Aza-Friedel-Crafts Reaction
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01158G, CommunicationZi-Biao Zhao, lei shi, Yaming Li, Fan-Jie Meng, Yong-Gui Zhou A facile enantioselective aza-Friedel-Crafts reaction of seven-membered cyclic N-sulfonylimines with naphthols was developed with cinchona alkaloid-based bifunctional organocatalyst, giving the chiral ε-sultams with up to 92% ee. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Zi-Biao Zhao Source Type: research

Bypassing the stereoselectivity issue: transformations of Kinugasa adducts from chiral alkynes and non-chiral acyclic nitrones
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00940J, PaperRafa ł Kutaszewicz, Barbara Grzeszczyk, Marcin Górecki, Olga Staszewska-Krajewska, Bartłomiej Furman, Marek Chmielewski Complementary strategies for the synthesis of non-racemictransβ-lactams bearing never-before-seen substitution patterns from mixtures of Kinugasa adducts are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Rafa ł Kutaszewicz Source Type: research

Push-Pull Isomers of Indolizino[6,5,4,3-def]phenanthridine Decorated by a Triarylboron Moiety
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00923J, PaperLei Dong, Felix Saraci, Kang Yuan, Xiang Wang, Suning Wang 1,3-dipolar cycloaddition reactions between a new azomethine ylide and three BPhMes2-functionalized internal alkynes produced three pairs of fluorescent push-pull regioisomers, which show distinct electronic and photophysical properties. All the six... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Lei Dong Source Type: research

Convenient one-pot access to 2H-3-nitro-thiochromenes from 2-bromobenzaldehydes, sodium sulfide and β-nitrostyrenes
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01060B, CommunicationDinh Hung Mac, Thanh Binh Nguyen, Thi Thu Huong Le, CHITOSE YOUHEI, Le Quy Hien An efficient synthesis of 2H-3-nitro-thiochromenes via cascade reaction was established. Starting from commercial available o-bromobenzaldehydes and -nitrostyrenes with sodium sulfide nonahydrate as an inexpensive sulfur source, various substituted thiochromenes were... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Dinh Hung Mac Source Type: research

Asymmetric Kinetic Resolution of Sulfides for the Construction of Unsymmetric Sulfides and Chiral 3,3-Disubstituted Oxindoles
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01065C, CommunicationKaiye Wang, Yanan Xiang, Zhujun Shi, Hongyu Wang, Na Li, Bo Tang A range of 3,3-disubstituted oxindoles accessed by para-quinone methides derived from isatins with thiols was used for the formation of unsymmetrical disulfides, and 3,3-disubstituted oxindoles with chiral quaternary carbon center... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Kaiye Wang Source Type: research

NIR Fluorescent Probe for Detection of Viscosity and Lysosome Imaging in Live Cells
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01222B, Papertong chen, Zikang Chen, Ruiyuan Liu, Shaobing Zheng Lysosome, as the cellular recycling center, is filled with numerous hydrolases that can degrade most cellular macromolecules. Studies have shown that the abnormality of viscosity in lysosome will disorder the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: tong chen Source Type: research

Bis-aminocyclopropenylidene carbene borane catalyzed imine hydrogenation
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01053J, PaperBlake S. N. Huchenski, Cheyenne J. Christopherson, Katherine N. Robertson, Alexander W. H. Speed Borenium-catalyzed hydrogenations of an imine made from a benzylamine are enabled by a steric interplay between cyclohexylborane and a BAC carbene: both are necessary for efficient reactivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 11, 2019 Category: Molecular Biology Authors: Blake S. N. Huchenski Source Type: research

The structure-based traceless specific fluorescence labeling of the smoothened receptor
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00654K, CommunicationDongxiang Xue, Lintao Ye, Jun Zheng, Yiran Wu, Xianjun Zhang, Yueming Xu, Tao Li, Raymond C. Stevens, Fei Xu, Min Zhuang, Suwen Zhao, Fei Zhao, Houchao Tao Inspired by recent progress in structural studies of the smoothened receptor (SMO), a group of affinity probes were developed to specifically light up SMO by grafting a small fluorescent group at the specific residue K395. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - O...
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Dongxiang Xue Source Type: research

meso-Aryl substituted stable unorthodox 5,10-porphodimethenes with α,β and β,β-N-methyl pyrrole connectivities: synthesis and spectroscopic, solid state and theoretical characterization
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01062A, CommunicationNyancy Halder, Mohandas Sangeetha, Dandamudi Usharani, Harapriya Rath meso-Aryl substituted highly stable single conformers of doubly mutant porphodimethenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Nyancy Halder Source Type: research

Discovery, biological evaluation, structure –activity relationships and mechanism of action of pyrazolo[3,4-b]pyridin-6-one derivatives as a new class of anticancer agents
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00616H, PaperQingqing Guo, Yao Luo, Shiyang Zhai, Zhenla Jiang, Chongze Zhao, Jianrong Xu, Ling Wang We have recently reported computational models for prediction of cell-based anticancer activity using machine learning methods. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Qingqing Guo Source Type: research

Practical preparation of diphenylmethyl ethers from 2-diphenylmethoxypyridine using catalytic iron(III) chloride
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01093A, PaperVan Hieu Tran, Minh Thanh La, Hee-Kwon Kim Highly efficient synthesis of diphenylmethyl ethers from alcohols and 2-diphenylmethoxypyridine in the presence of iron chloride has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Van Hieu Tran Source Type: research

Late stage functionalization of heterocycles using hypervalent iodine(III) reagents
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00694J, Review ArticleRajnish Budhwan, Suman Yadav, Sandip Murarka Late stage functionalization (LSF) through direct X-H manipulations (X = C, N) enable synthetic chemists to accelerate the diversification of natural products, agrochemicals and pharmaceuticals allowing rapid access to novel... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Rajnish Budhwan Source Type: research

Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01299K, PaperYi He, Danjun WU, Zhenghua Li, Koen Robeyns, Luc Van Meervelt, Erik V Van der Eycken A gold-catalysed post-Ugi chemo- and diastereoselective cascade dearomative spirocyclization/1,6-addition sequence is disclosed for the synthesis of diverse fused polyheterocyclic scaffolds bearing indole, pyrrole, benzothiophene, furan or electron-rich arene moieties from... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Yi He Source Type: research

Photoaffinity Palladium Reagents for Protein-Protein Interaction Capture
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01048C, CommunicationQizhen Zheng, Zhengyuan Pang, Jingwei Liu, Yi Zhou, Yang Sun, Zheng Yin, Zhiyong Lou Protein-protein interactions (PPIs) are indispensable in almost all cellular processes. Probing complex PPIs provides new insights into the biological system of interest and paves the way for the development of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2019 Category: Molecular Biology Authors: Qizhen Zheng Source Type: research

How an Early or Late Transition State Impacts the Stereoselectivity of Tetrahydropyran Formation by Intramolecular oxa-Michael Addition
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00750D, PaperDaniel Csokas, Annabel Xuan Ying Ho, Raghunath Ramabhadran, Roderick Wayland Bates The intramolecular oxa-Michael addition giving tetrahydropyrans has been examined experimentally using both acidic and basic catalysis. With acidic catalysis, the diequatorial product is exclusively obtained in a kinetically controlled reaction... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 8, 2019 Category: Molecular Biology Authors: Daniel Csokas Source Type: research

Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates
We report novelcis-restricted combretastatin A-4 analogues with potent antiproliferative effects in breast cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 8, 2019 Category: Molecular Biology Authors: Niamh M. O'Boyle Source Type: research