New Friedel –Crafts strategy for preparing 3-acylindoles
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02094A, CommunicationLian-Hua Li, Zhi-Jie Niu, Yong-Min Liang A new Friedel –Crafts acylation generates diverse high-biological value 3-acylindoles, and forms a new C–C bond under transition-metal-free conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2018 Category: Molecular Biology Authors: Lian-Hua Li Source Type: research

Local versus global aromaticity in azuliporphyrin and benziporphyrin derivatives
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01672K, PaperAbhik Ghosh, Simon Larsen, Jeanet Conradie, Cina Foroutan-Nejad Magnetically induced current density calculations have elucidated the question of globalversus local aromaticity in carbaporphyrinoids and their metal complexes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2018 Category: Molecular Biology Authors: Abhik Ghosh Source Type: research

Visible-Light-Promoted Radical Acylation/Cyclization of Alkynoates with Aldehydes for the Synthesis of 3-Acylcoumarins
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02232A, PaperQiumei Wang, Chao Yang, Chao Jiang A new, efficient, and atom-economic visible-light-promoted radical acylation/cyclization of alkynoates with aldehydes was developed for the synthesis of 3-acylcoumarins. The reaction undergoes a domino radical addition/5-exo cyclization, and ester migration... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2018 Category: Molecular Biology Authors: Qiumei Wang Source Type: research

Four-component acyloxy-trifluoromethylation of arylalkenes mediated by a photoredox catalyst
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02239A, CommunicationXiaocong Zhou, Guijie Li, Zongzhou Shao, Kun Fang, Hongjun Gao, Yuanqiang Li, Yuanbin She A four-component intermolecular trifluoromethylation –acyloxylation of arylalkenes induced by visible light has been developed in the presence of the photoredox catalyst Ru(bpy)3(PF6)2 under mild reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2018 Category: Molecular Biology Authors: Xiaocong Zhou Source Type: research

Direct synthesis of indenes via a rhodium-catalyzed multicomponent Csp2 —H annulation reaction
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02359J, Communicationpierre Querard, Chao-Jun Li A highly efficient, direct and multicomponent route for the synthesis of indenes is reported herein. This process is catalyzed by rhodium(III) complex and conducted under very mild conditions, making the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2018 Category: Molecular Biology Authors: pierre Querard Source Type: research

Iron(III)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02151A, CommunicationYu Wang, Wei Wang, Ruyun Tang, Zhenhua Liu, Weihua Tao, Zhongxue Fang A Fe-catalyzed highly regioselective α,β-difunctionalization of vinylarenes with diphenylphosphine oxides and anilines is disclosed, in which α,β-aminophosphinoylation is efficiently and conveniently constructed with good functional compatibility and a broad substrate scope. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and ...
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2018 Category: Molecular Biology Authors: Yu Wang Source Type: research

Origins of the Enantioselectivity of Palladium Catalyst with BINOL-Phosphoric Acid Ligands
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02271B, PaperJun Zhang Transition metal-catalyzed C –H activation with high enantioselectivity is a new and challenging field. BINOL-phosphoric acid ligands ((R)-TRIP) was found to be able to induce high enantioselectivity in aziridination of aliphatic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2018 Category: Molecular Biology Authors: Jun Zhang Source Type: research

Synthesis of N-Arylsulfonamides through Pd-catalyzed Reduction Coupling Reaction of Nitroarenes with Sodium Arylsulfinates
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02226G, PaperBo Yang, Chang Lian, Guanglu Yue, Danyang Liu, Liyan Wei, Yi Ding, Xiancai Zheng, Kui Lu, Di Qiu, Xia Zhao A novel one-step direct reductive coupling reaction between nitroarenes and sodium arylsulfinates was realized in the presence of inexpensive Pd/C catalyst. During this procedure, readily available nitroarenes are employed as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2018 Category: Molecular Biology Authors: Bo Yang Source Type: research

KHMDS Mediated Synthesis of 9-Arylfluorenes from Dibenzothiophene dioxides and Arylacetonitriles by Tandem SNAr-Decyanation-Based Arylation
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02355G, CommunicationM. Bhanuchandra, Saketh Mylavarapu, MAMTA YADAV A straightforward KHMDS mediated synthetic route to 9-arylfluorenes from readily available starting materials has been developed. This reaction involves SNAr reactions of dioxide with arylacetonitriles, followed by decyanation reaction. The... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2018 Category: Molecular Biology Authors: M. Bhanuchandra Source Type: research

A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates
We report an efficient approach to synthesize sulfonated indenonesvia a radical cascade cyclization of 2-alkynylbenzonitriles with sodium arylsulfinates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2018 Category: Molecular Biology Authors: Bang Zhou Source Type: research

Novel peptide dendrimer LTP efficiently facilitates transfection of mammalian cells
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02039F, PaperKsenia V. Kozhikhova, Sergey M. Andreev, Igor P. Shilovskiy, Anastasiia V. Timofeeva, Alina R. Gaisina, Artem A. Shatilov, Evgeny A. Turetskiy, Igor M. Andreev, Valeriy V. Smirnov , Anton S. Dvornikov, Musa R. Khaitov One of the urgent problems of gene therapy is the search for an effective transfection methods. Synthetic cationic peptides (CP) are considered as one of the most promising approaches for... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2018 Category: Molecular Biology Authors: Ksenia V. Kozhikhova Source Type: research

An unexpected thermal-ring-rearrangement of benzochromenes to inden-3-yl-naphthols with pTsOH
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02264J, PaperSrinivasarao Yaragorla, Tabassum Khan Described here is the first report of an unexpected thermal-ring rearrangement (TRR) of benzochromenes to indene derivatives promoted bypTsOH, which proceeds through the protonation of benzochromenes by an acid catalysts followed by ring-opening and ring-closure by an intramolecular Friedel –Crafts cyclization. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2018 Category: Molecular Biology Authors: Srinivasarao Yaragorla Source Type: research

Synthesis of the β-linked GalNAc-Kdo Disaccharide Antigen of the Capsular Polysaccharide of Kingella kingae KK01
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02340A, CommunicationLiqin Zhuang, Yan Chen, Qixin Lou, You Yang The first construction of the challenging β-(1→5)-linked GalNAc-Kdo skeleton is described for the synthesis of the disaccharide antigen of the capsular polysaccharide ofKingella kingae KK01. TfOH-catalyzed glycosylation ofN-Troc-protected... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2018 Category: Molecular Biology Authors: Liqin Zhuang Source Type: research

Highly diastereoselective synthesis of cyclopropane-fused spiro-pseudoindoxyl derivatives through [2 + 1] annulation of 2-ylideneoxindoles and sulfonium bromides
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02034E, PaperXue Tang, Hong-Ping Zhu, Jin Zhou, Yang Chen, Xiao-Li Pan, Li Guo, Jun-Long Li, Cheng Peng, Wei Huang Compared with the intensively studied C3 spirooxindoles, limited reliable approaches are reported for synthesizing structurally analogous C2-spiropseudoindoxyl derivatives. Here, we developed an efficient method for highly diastereoselective synthesis of cyclopropane-fused... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2018 Category: Molecular Biology Authors: Xue Tang Source Type: research

Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02284D, PaperSandip B. Jadhav, Satish B. Thopate, Jagadeesh Babu Nanubolu, Rambabu Chegondi The rhodium-catalyzed arylative cyclization of enone tethered-cyclohexadienones has been developed with high efficiency, thus providingcis-fused bicyclic enones in good yields and with excellent diastereoselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2018 Category: Molecular Biology Authors: Sandip B. Jadhav Source Type: research

Catalyst-free 1:2 annulation of quinolines with trifluoroacetylacetylenes: a one-pot access to oxazinoquinolines decorated by trifluoromethyl, acetylene and ketone functions
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02379D, CommunicationBoris Trofimov, Kseniya Belyaeva, Lina Nikitina, Andrei Afonin, A. V. Vashchenko, Vasily Muzalevskiy, Valentine Nenajdenko Metal- and solvent-free reaction of quinolines with two molecules of aryltrifluoroacetylacetylenes afforded 3-arylethynyl-3-trifluoromethyl-1,3-oxazinoquinolines in up to 92% yields. The formation of zwitterionic intermediate at the first step triggered multistep domino... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2018 Category: Molecular Biology Authors: Boris Trofimov Source Type: research

Fluorogenic “photoclick” labelling of DNA using a Cy3 dye
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02068J, CommunicationBenjamin Lehmann, Hans-Achim Wagenknecht Two 2 ′-deoxyuridines as new building blocks for automated DNA synthesis carry a small aryltetrazole as a “photoclickable” group at their 5-positions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Benjamin Lehmann Source Type: research

Solvent and catalyst free ring expansion of Indoles: A simple synthesis of highly functionalized Benzazepines
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01825A, PaperManickam Bakthadoss, Polu Vijay Kumar, Tadiparthi Thirupathi Reddy, Sharada Savaraiah Duddu Highly functionalized benzazepines have been synthesized by using various substituted Indoles and dialkyl acetylenedicarboxylates under thermal and open air condition. The reaction was carried out in a solvent and catalyst... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Manickam Bakthadoss Source Type: research

Regioselective [3+2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02352B, CommunicationWenjun Li, Kun Liu, Xinye Shang, Yuyu Cheng, Xiaoyong Chang, Pengfei Li A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and 1,3-dicarbonyl compounds has been developed. In the presence of DMAP combined with Et3N, hydrazonyl chlorides reacted with N-phenyl-3-oxobutanamides smoothly to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Wenjun Li Source Type: research

Efficient Assembly of Hydantoins via a [3+2] Annulation Involving Azaoxyallyl Cations
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02321B, Communicationshaofa sun, rongxing chen, gangqiang wang, Jian Wang A new [3+2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: shaofa sun Source Type: research

Copper-catalyzed synthesis of 2-acylbenzo[b]thiophenes from 3-(2-iodophenyl)-1-arylpropan-1-ones and potassium sulfide under aerobic conditions
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02315H, CommunicationZhilei Zeng, Liang Chen, Cheng Qian, Xiaoming Zhu, Yuzhong Yang, Jianbing Liu, Yuan Yang, Yun Liang An efficient and convenient method was developed for the formation of 2-actylbenzo[b]thiophenes via a copper-catalyzed coupling cyclization of 3-(2-iodophenyl)-1-arylpropan-1-ones with K2S. The reaction proceeds double thiolation reaction between C(sp2) atom... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Zhilei Zeng Source Type: research

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01929K, Review ArticleRhydian H. Beddoe, Helen F. Sneddon, Ross M. Denton This Review article provides a summary and critical metrics-based analysis of recently developed catalytic Mitsunobu reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Rhydian H. Beddoe Source Type: research

Hydroarylation of unsaturated carbon –carbon bonds in cross-conjugated enynones under the action of superacid CF3SO3H or acidic zeolite HUSY. Reaction mechanism and DFT study on cationic intermediate species
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01985A, PaperMaiia I. Aleksandrova, Stanislav V. Lozovskiy, Steve Saulnier, Alexander A. Golovanov, Irina A. Boyarskaya, Aleksander V. Vasilyev Reactions of enynones with arenes in TfOH-Py or with zeolite HUSY lead to products of hydroarylation of the acetylene bond. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Maiia I. Aleksandrova Source Type: research

Synthesis and properties of a lysosome-targeted fluorescent ionophore based on coumarins and squaramides
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01957F, CommunicationXiao-Qiao Hong, Xi-Hui Yu, Kun Zhang, Wen-Hua Chen In this paper we present the first example of a lysosome-targeted fluorescent ionophore. Specifically, we have synthesized one squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Xiao-Qiao Hong Source Type: research

Sulfono- γ-AA modified peptides that inhibit HIV-1 fusion
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02159G, PaperOlapeju Bolarinwa, Meng Zhang, Erin Mulry, Min Lu, Jianfeng Cai Peptide4 with sulfono- γ-AA1 (γK) substitution and hydrocarbon stapling exhibited potent anti-HIV activity and improved biostability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Olapeju Bolarinwa Source Type: research

Synthesis of α-alkylated γ-butyrolactones with concomitant anhydride kinetic resolution using a sulfamide-based catalyst
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02248H, CommunicationRomain Claveau, Brendan Twamley, Stephen J. Connon The organocatalytic kinetic resolution of chiral asymmetrically substituted succinic anhydrides has been developedvia cycloaddition with aldehydes in the presence of a novel sulfamide catalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Romain Claveau Source Type: research

Tetracyclic Pyrazine-fused Furazans as Insensitive Energetic Materials: Syntheses, Structures, and Properties
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02155D, CommunicationQi Sun, Xin Li, Qiuhan Lin, Ming Lu Energetic compounds with fused tetracyclic backbones were synthesized and fully characterized, and their structures were confirmed by single crystal X-ray diffraction. Changes from nonplanar to planar structures led their densities... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2018 Category: Molecular Biology Authors: Qi Sun Source Type: research

FeCl3-promoted tandem 1,4-conjugate addition/6-endo-dig cyclization/oxidation of propargylamines and benzoylacetonitriles/malononitriles: direct access to functionalized 2-aryl-4H-chromenes
Org. Biomol. Chem., 2018,16,7191-7202 DOI: 10.1039/C8OB01927D, PaperXinwei He, Hui Wang, Xiaoting Cai, Qianqian Li, Jiajia Tao, Yongjia Shang Efficient and concise procedure for the synthesis of 2-aryl-4H-chromenes based on a tandem reaction of propargylamines and benzoylacetonitriles/malononitriles in the presence of FeCl3 as an environmentally friendly promoter. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Xinwei He Source Type: research

Ruthenium(II)-catalyzed synthesis of indazolone-fused cinnolines via C –H coupling with diazo compounds
Org. Biomol. Chem., 2018,16,7236-7244 DOI: 10.1039/C8OB02071J, PaperLin Su, Zheng Yu, Peiling Ren, Zhi Luo, Wei Hou, Hongtao Xu Ruthenium(II)-catalyzed C(sp2) –H activation and intermolecular coupling with diazo compounds were realized for the efficient and rapid synthesis of indazolone-fused cinnolines. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Lin Su Source Type: research

Facile synthesis of triphenylenes and triphenylene/phenanthrene fused heteroaromatics
Org. Biomol. Chem., 2018,16,7134-7138 DOI: 10.1039/C8OB01930D, CommunicationVijay Gupta, Satish K. Pandey, Ravi P. Singh Facile synthesis of triphenylene fused imidazoles, quinoxaline and phenanthro[9,10-d]-fused pyrazinesvia CAN-mediated oxidative cyclodehydrogenation. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Vijay Gupta Source Type: research

Organic amine-mediated free-radical carbocyclization reactions of 2,2,2-trihalogeno-substituted N-(2-alkynylphenyl)acetamides
Org. Biomol. Chem., 2018,16,7265-7273 DOI: 10.1039/C8OB01870G, PaperTsung-Han Chuang, Che-Ping Chuang An organic amine-mediated carbocyclization reaction for the synthesis of 3-halogeno-substituted 4-benzoylquinolin-2-(1H)-ones is described. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Tsung-Han Chuang Source Type: research

Suzuki –Miyaura coupling of unstrained ketones via chelation-assisted C–C bond cleavage
Org. Biomol. Chem., 2018,16,7174-7177 DOI: 10.1039/C8OB02075B, PaperCheng Jiang, Zhao-Jing Zheng, Tian-Yang Yu, Hao Wei Herein, we report that unstrained ketones can be efficiently employed as electrophiles in Suzuki –Miyaura reactionsvia catalytic activation of unstrained C –C bonds assist by an N-containing directing group. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Cheng Jiang Source Type: research

Fluorinated triazole-containing sphingosine analogues. Syntheses and in vitro evaluation as SPHK inhibitors
Org. Biomol. Chem., 2018,16,7230-7235 DOI: 10.1039/C8OB01867G, PaperMargarita Escudero-Casao, Adri à Cardona, Raúl Beltrán-Debón, Yolanda Díaz, M. Isabel Matheu, Sergio Castillón Fluorinated triazole-containing sphingosine analogues as SPHK inhibitors were synthesized from a common alkynyl aziridine key synthonvia enantioselective organocatalyzed aziridination. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Margarita Escudero-Casao Source Type: research

Visible light catalyzed reaction of α-bromochalcones with chalcones: direct access to the urundeuvine scaffold
Org. Biomol. Chem., 2018,16,7152-7156 DOI: 10.1039/C8OB01881B, PaperBhupal Singh Karki, Mukund M. D. Pramanik, Ruchir Kant, Namrata Rastogi The α-keto vinyl radicals generated from α-bromochalcones under visible light photoredox catalyzed conditions were trapped by chalcones. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Bhupal Singh Karki Source Type: research

Electrophilic chloro( ω-alkoxy)lation of alkenes employing 1-chloro-1,2-benziodoxol-3-one: facile synthesis of β-chloroethers
Org. Biomol. Chem., 2018,16,7203-7213 DOI: 10.1039/C8OB01634H, PaperYimin Jia, Long Chen, Huaibin Zhang, Ying Zheng, Zhong-Xing Jiang, Zhigang Yang A four-component method for the electrophilic chloro( ω-alkoxy)lation of alkenes has been performed employing cyclic ethers, thionyl chloride, and chloroiodine(III) reagent. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Yimin Jia Source Type: research

Synthesis of medium-sized (6 –7–6) ring compounds by iron-catalyzed dehydrogenative C–H activation/annulation
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01496E, PaperNiranjan Panda, Irshad Mattan, Subhadra Ojha, Chandra Shekhar Purohit Iron-catalyzed synthesis of fused seven-membered ring compounds by intramolecular hydroarylation of alkynes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Niranjan Panda Source Type: research

Regioselective synthesis of isoxazole and 1,2,4-oxadiazole-derived phosphonates via [3 + 2] cycloaddition
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02257G, PaperBohdan A. Chalyk, Alona S. Sosedko, Dmitriy M. Volochnyuk, Andrey A. Tolmachev, Konstantin S. Gavrilenko, Oleksandr S. Liashuk, Oleksandr O. Grygorenko The regioselective synthesis of 3,4- and 3,5-disubstituted izoxazole- and 1,2,4-oxadiazole-derived phosphonates is described, including analogues of phosphohistidine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Bohdan A. Chalyk Source Type: research

Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01994K, PaperByung Hoon Ahn, Ill Young Lee, Hee Nam Lim The one-pot protocol by the dendritic copper powder-mediated Knoevenagel condensation/annelation is delineated here for the synthesis of 3-amido-2-quinolones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Byung Hoon Ahn Source Type: research

Dynamic Diels –Alder reactions of maleimide–furan amphiphiles and their fluorescence ON/OFF behaviours
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01944D, PaperFen Li, Xiaohui Li, Xin Zhang Dynamic Diels –Alder additions of maleimide–furan amphiphiles lead to reversible fluorescence ON/OFF behaviours and exchange of furan moieties. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Fen Li Source Type: research

Identification of a Lysine 4-Hydroxylase from the Glidobactin Biosynthesis and Evaluation of Its Biocatalytic Potential
We present the functional characterization of GlbB, a lysine 4-hydroxylase from the glidobactin biosynthetic gene cluster. Despite its narrow substrate specificity, GlbB is able to catalyze the hydroxylation of L-lysine... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Alexander Amatuni Source Type: research

Metal-free Photocatalytic Thiol-Ene/Thiol-Yne Reactions
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02313A, PaperSarbjeet Kaur, Gaoyuan Zhao, Evan Busch, Ting Wang The organic photocatalyst (9-mesityl-10-methylacridinum tetrafluoroborate) in presence of visible light is used to initiate thiol-ene and thiol-yne reactions. The thiyl radicals are generated upon quenching of photoexcited catalyst with a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Sarbjeet Kaur Source Type: research

Metal-free KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins using Bunte salts
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02268B, CommunicationGuoqing Li, Guomeng Zhang, Xuewu Deng, Kunyu Qu, Hua Wang, Wei Wei, Daoshan Yang An efficient and eco-friendly protocol for KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins with Bunte salts was established. The reaction worked smoothly under metal-free conditions to afford a wide range of sulfenylated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Guoqing Li Source Type: research

Stereoselective Synthesis of E-3-(Arylmethylidene)-5-(Alkyl/Aryl)-2(3H)-Furanones by Sequential Hydroacyloxylation-Mizoroki-Heck Reactions of Iodoalkynes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02063A, PaperGopinathan Muthusamy, Sunil Vasant Pansare A modular, stereoselective synthesis of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones was developed. The methodology features regioselective addition of β-aryl acrylic acids to iodoacetylenes to furnish the Z-acyloxy iodoalkenes. A stereoselective 5-exo-trig Mizoroki-Heck reaction of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Gopinathan Muthusamy Source Type: research

Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02172D, PaperFang Ke, Peng Zhang, Chen Lin, Xiaoyan Lin, Jianhua Xu, Xiangge Zhou An efficient copper-catalyzed three-component reactions of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles with 1,10-phenanthroline as ligand has been developed. A variety of substituted benzimidazole derivatives can be... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2018 Category: Molecular Biology Authors: Fang Ke Source Type: research

A novel peptide conformation: the γ-bend ribbon
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02279H, PaperBruno Drouillat, Cristina Peggion, Barbara Biondi, Karen Wright, Fran çois Couty, Marco Crisma, Fernando Formaggio, Claudio Toniolo Unlike the extensively investigated relationship between the peptide β-bend ribbon and its prototypical 310-helix conformation, the corresponding relationship between the narrower γ-bend ribbon and its regular γ-helix counterpart still remains... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2018 Category: Molecular Biology Authors: Bruno Drouillat Source Type: research

A cascade synthesis of S-allyl benzoylcarbamothioates via Mumm-type rearrangement
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02293C, CommunicationBhisma K Patel, Anjali Dahiya, Wajid Ali, Tipu Alam A catalyst and solvent free synthesis of S-allyl benzoylcarbamothioates has been achieved from the in situ generated benzoylcarbonimidothioates obtained by reacting MBH alcohols with aroyl isothiocyanates. An intramolecular thia-Michael addition... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2018 Category: Molecular Biology Authors: Bhisma K Patel Source Type: research

A convenient stereoselective access to novel 1,2,4-triazepan-3-ones/thiones via reduction or reductive alkylation of 7-membered cyclic semicarbazones and thiosemicarbazones
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01766B, PaperAnastasia Fesenko, Mikhail Grigoriev , Anatoly Shutalev A general stereoselective approach to previously unknown 1,2,4-triazepane-3-thiones/ones based on reduction or reductive alkylation of readily available 2,4,5,6-tetrahydro-3H-1,2,4-triazepine-3-thiones/ones has been developed. The approach involved treatment of tetrahydrotriazepines with sodium cyanoborohydride... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2018 Category: Molecular Biology Authors: Anastasia Fesenko Source Type: research

Synthesis and Suzuki-Miyaura cross coupling reactions for post synthetic modification of a tetrabromo-anthracenyl porphyrin
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02150C, PaperJoffrey Pijeat, Yannick J. Dappe, Pierre Thu éry, Stephane Campidelli The outstanding properties of porphyrins and the extreme versatility of their synthesis and their functionalisation constitute real assets for the fabrication of opto- and electroactive materials or for biological applications.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2018 Category: Molecular Biology Authors: Joffrey Pijeat Source Type: research

Syntheses, anti-cancer activity of CO-releasing molecules with targeting galactose receptor
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01921E, Paperjili li, quan yi zhao, jinglong zhang, qiuping zhang, zhongjie bai, dian he, zhen wang, yonglin chen, bin liu CO-releasing molecules (CORMs ) containing cobalt have many bioactivities ,but most of them do not dissolve in water and have no selectivity to tissue and organs. On the basis of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2018 Category: Molecular Biology Authors: jili li Source Type: research

Four-component acyloxy-trifluoromethylation of arylalkenes mediated by photoredox catalyst
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02239A, CommunicationXiaocong Zhou, Guijie Li, Zongzhou Shao, Kun Fang, Hongjun Gao, Yuanqiang Li, Yuan-Bin She A four-component intermolecular trifluoromethylation-acyloxylation of arylalkenes induced by visible light has been developed in the presence of a photoredox catalyst Ru(bpy)3(PF6)2 under mild reaction conditions. A new Umemoto ’s reagent was... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2018 Category: Molecular Biology Authors: Xiaocong Zhou Source Type: research