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Governing the DNA-binding mode of styryl dyes by the length of their alkyl substituents - From intercalation to major groove binding
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02736B, PaperDaria V. Berdnikova, Nikolai I. Sosnin, Olga Fedorova, Heiko Ihmels A series of monomeric and homodimeric 4-alkoxystyryl(pyridinium) dyes was synthesized and their DNA-binding properties were investigated. We found that the length of the alkyl substituent has a crucial influence on... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 15, 2017 Category: Molecular Biology Authors: Daria V. Berdnikova Source Type: research

Synthesis of polyheterocycles via multicomponent reactions
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02305G, Review ArticleIlich A. Ibarra, Alejandro Islas-Jacome, Eduardo Gonzalez-Zamora Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Ilich A. Ibarra Source Type: research

Synthesis of thieno[2,3-b]quinoline and selenopheno[2,3-b]quinoline derivatives via iodocyclization reaction and a DFT mechanistic study
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02523H, PaperAmol D. Sonawane, Dinesh R. Garud, Taro Udagawa, Mamoru Koketsu Thieno[2,3-b]quinoline and selenopheno[2,3-b]quinoline derivatives were synthesized by the regioselective iodocyclization reaction of 3-alkynyl-2-(methylthio)quinolines and 3-alkynyl-2-(methylseleno)quinolines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Amol D. Sonawane Source Type: research

Synthesis and characterization of water-soluble macrocyclic peptides stabilizing protein [small alpha]-turn
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02852K, PaperLei Wang, Pascale Coric, Kexin Zhu, W Liu, Michel Vidal, Serge Bouaziz, Sylvain Broussy Short peptides composed of naturally occurring amino acids are usually unstructured in aqueous media. The installation of covalent constraints within their side chains or backbones, resulting in the formation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Lei Wang Source Type: research

Total synthesis of selaginpulvilins A and C
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02609A, PaperBhavani Shankar Chinta, Beeraiah Baire An efficient strategy for the formal total synthesis of selaginpulvilins A and C has been reported. This approach involves 6 and 7 linear synthetic operations and is associated with 10% and 7% overall yields respectively for selaginpulvilins A and C. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Bhavani Shankar Chinta Source Type: research

Synthesis of spirocyclic orthoesters by 'anomalous' rhodium(II)-catalysed intramolecular C-H insertions
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02123B, PaperFanny J. Lombard, Romain J. Lepage, Brett D. Schwartz, Ryne C. Johnston, Peter C. Healy, Elizabeth H. Krenske, Mark J. Coster Spirocyclic orthoesters are synthesised by 'anomalous' Rh(II)-catalysed intramolecular C-H insertion reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Fanny J. Lombard Source Type: research

Synthesis of spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles via divergent, thermally induced tandem cyclization/migration of alkyne-tethered diazo compounds
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02802D, CommunicationCheng Zhang, Shanliang Dong, Yang Zheng, Ciwang He, Jiaolong Chen, Jingsen Zhen, Lihua Qiu, Xinfang Xu A thermally induced, substrate-dependent divergent outcome of alkynyl diazoamides for the synthesis of spiro-4H-pyrazoles and fused 1H-pyrazoles has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Cheng Zhang Source Type: research

Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02794J, PaperJie Zheng, Ming He, Baohua Xie, Lu Yang, Zhiye Hu, Haibing Zhou, Chune Dong A series of optical active pyrano[3,2-c]chromenes have been synthesized through asymmetric domino reaction of 4-hydroxy-2H-chromen-2-ones with malononitriles. The targeted molecules were obtained in excellent yields and enantioselectivities (up to 94%... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 14, 2017 Category: Molecular Biology Authors: Jie Zheng Source Type: research

Neutral Glycoconjugated Amide-Based Calix[4]arenes: Complexation of Alkali Metal Cations in Water
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02955A, PaperNikola Cindro, Josip Pozar, Dajana Barisic, Nikola Bregovic, Katarina Piculjan, Renato Tomas, Leo Frkanec, Vladislav Tomisic Cation complexation in water presents a unique challenge in calixarenes chemistry, mostly due to a fact that vast majority of calixarene-based cation receptors is not soluble in water or their... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 13, 2017 Category: Molecular Biology Authors: Nikola Cindro Source Type: research

Synthesis and structural investigation of a series of mannose-containing oligosaccharides using mass spectrometry
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.S. Daikoku, R. Pendrill, Y. Kanie, Y. Ito, G. Widmalm, O. Kanie Gas-phase collision-induced dissociation and acid hydrolysis of mannose-containing oligosaccharides were performed, which revealed the reactivity order of linkage isomers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 13, 2017 Category: Molecular Biology Authors: S. Daikoku Source Type: research

Palladium-catalyzed Synthesis of Fluoreones from Bis(2-bromophenyl)methanols
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02895D, CommunicationQian Gao, Senmiao Xu A palladium-catalyzed synthesis of fluorenones has been developed. A variety of bis(2-bromophenyl)methanols could undergo reaction smoothly in the presence of Pd(OAc)2, affording a series of fluorenones in moderate to good... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 13, 2017 Category: Molecular Biology Authors: Qian Gao Source Type: research

DABCO-Catalyzed Silver-Promoted Direct Thiolation of Pyrazolones with Diaryl Disulfides
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02860A, PaperAkkharaphong Thupyai@gmail.com, Chaleena Pimpasri, Sirilata Yotphan A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with aryl disulfides is described. Using a combination of DABCO and silver (I) acetate, the C-S bond formation proceeds... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 13, 2017 Category: Molecular Biology Authors: Akkharaphong Thupyai at gmail.com Source Type: research

Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01929G, PaperSayantan Paul, Asish K. Bhattacharya An efficient, transition-metal free and direct C-arylation of 3-hydroxychromone moieties in presence of base, air as oxidant and arylhydrazines as arylating agent to furnish highly biologically active flavonols or 3-hydroxyflavones... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 13, 2017 Category: Molecular Biology Authors: Sayantan Paul Source Type: research

Stereocontrolled Glycoside Synthesis by Activation of Glycosyl Sulfone Donors with Scandium(III) triflate
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02792C, PaperAmandine Xolin, Romain Losa, Aicha Kaid, Cedric Tresse, Jean-Marie Beau, Francois-Didier Boyer, Stephanie Norsikian The activation of aryl glycosyl sulfone donors has been achieved using scandium(III) triflate and has led to the selective preparation of [small alpha]-mannosides resulting from a post-glycosylation anomerization. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Amandine Xolin Source Type: research

A regiospecific rhamnosyltransferase from Epimedium pseudowushanense catalyzes the 3-O-rhamnosylation of prenylflavonols
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02763J, PaperKeping Feng, Ridao Chen, Kebo Xie, Dawei Chen, Baolin Guo, xiao liu, Jimei Liu, Min Zhang, Jungui Dai Epimedium is used in traditional Chinese medicine and contains flavonol glycosides that exhibit multiple biological activities. These bioactive flavonol glycosides usually have a rhamnose moiety at the 3-OH position of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Keping Feng Source Type: research

Structural revision of two unusual rhamnofolane diterpenes, curcusones I and J, by means of DFT calculations of NMR shifts and coupling constants
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02916K, PaperAriel Marcelo Sarotti The stereochemical revision of two recently reported rhamnofolane diterpenes, curcusones I and J, was enabled by quantum calculations of NMR shifts and coupling constants at DFT levels. The DP4+ results... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Ariel Marcelo Sarotti Source Type: research

Convenient Synthesis of 2-Amino-3-(arylthio)indoles via Rh-Catalyzed Reaction of 3-Diazoindol-2-imines with Thioesters
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02597A, PaperFanghui Ma, Jing Qian, Ping Lu, Yanguang Wang 2-Amino-3-(arylthio)indoles were conveniently synthesized via the Rh(II)-catalyzed C-S/N-C coupling reaction between 3-diazoindol-2-imines and thioesters. The products could be further oxidized to 2-amino-3-(arylsulfonyl)indoles by m-chloroperbenzoic acid and the N-sulfonyl group could... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Fanghui Ma Source Type: research

Teaching an Old Scaffold New Recognition Tricks: Oligopyrrolamide Antagonists of IAPP Aggregation
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02910A, PaperSunil Kumar, Maria C Vogel, Andrew D Hamilton A library of N-substituted oligopyrrolamides was designed to modulate the aggregation kinetics of islet amyloid polypeptide (IAPP). IAPP is a hormonal peptide, co-secreted with insulin in the pancreatic [small beta]-cells. IAPP... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Sunil Kumar Source Type: research

The Renascence of Continuous-Flow Peptide Synthesis - An abridged account of solid and solution-based approaches
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02759A, Review ArticleChristopher Gordon Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups. However, despite the various... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Christopher Gordon Source Type: research

Bioinspired Total Synthesis of Tetrahydrofuran Lignans by Tandem Nucleophilic Addition/Redox Isomerization/Oxidative Coupling and Cycloetherification Reactions as Keysteps
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Pratap R. Jagtap, Ivana Cisarova, Ullrich Jahn A very short three-step approach to trans,trans,trans-2,5-diaryl-3,4-dimethyltetrahydrofuran lignans is reported. The carbon skeleton is assembled in a single step based on an unprecedented tandem reaction consisting of 1,2-addition of aryllithium... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Pratap R. Jagtap Source Type: research

Target specificity of mammalian DNA methylation and demethylation machinery
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02574B, Review ArticleMirunalini Ravichandran, Renata Zofia Jurkowska, Tomasz Piotr Jurkowski DNA methylation is an essential epigenetic modification for mammalian embryonic development and biology. DNA methylation pattern across the genome, together with other epigenetic signals, is responsible for the transcriptional profile... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 12, 2017 Category: Molecular Biology Authors: Mirunalini Ravichandran Source Type: research

Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02576A, CommunicationYing Yang, Zi-Lin Hu, Ren-Hao Li, Yi-Hui Chen, Zhuang-Ping Zhan An efficient approach for the preparation of pyrazolesvia a Pd(II)/Cu(I)-catalyzed Sonogashira coupling/cyclization ofN-propargyl sulfonylhydrazones has been established. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 11, 2017 Category: Molecular Biology Authors: Ying Yang Source Type: research

Pd-Catalyzed C-H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02486J, CommunicationThomas A. Alanine, Stephen Stokes, Craig A. Roberts, James. S. Scott Pd-Catalysed C-H aziridination of 3,3,5,5-tetrasubsituted piperazin-2-ones catalysed by succinic acid. The mechanistic role of the acid is investigated through kinetics experiments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 11, 2017 Category: Molecular Biology Authors: Thomas A. Alanine Source Type: research

Highly efficient asymmetric construction of novel indolines and tetrahydroquinoline derivatives via aza-Barbier/C-N coupling reaction
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02891A, CommunicationTao Guo, Bin-Hua Yuan, Wen-Jie Liu An efficient approach towards stereoselective synthesis of chiral indolines and tetrahydroquinolinesvia Zn-mediated allylation of chiral-N-tert-butanesulfinyl imines and intramolecular C-N cross-coupling is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 11, 2017 Category: Molecular Biology Authors: Tao Guo Source Type: research

Exploring bis-(amino)cyclopropenylidene as a non-covalent Bronsted base catalyst in conjugate addition reactions
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02882B, CommunicationGurdeep Singh, Prithwish Goswami, Vijaya Anand Ramasamy Bis-(amino)cyclopropenylidene has been utilised as a non-covalent Bronsted base catalyst in the 1,6-conjugate addition of carbon nucleophiles to p-QMs. This protocol allows to access unsymmetrical diaryl- and triarylmethanes in good... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 11, 2017 Category: Molecular Biology Authors: Gurdeep Singh Source Type: research

Solvent-sensitive Signs and Magnitudes of Circularly Polarised Luminescence and Circular Dichroim Spectra: Probing Two Phenanthrenes as Emitters Endowed with BINOL Derivatives
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02308A, PaperShoma Nakanishi, Nobuyuki Hara, Natsuki Kuroda, Nobuo Tajima, Michiya Fujiki, Yoshitane Imai AC2-symmeric binaphthyl framework bearing phenanthrene as the emitter exhibited circularly polarised luminescence (CPL) in dilute solutions. The CPL and circular dichroism signs of the luminophores were altered by the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 11, 2017 Category: Molecular Biology Authors: Shoma Nakanishi Source Type: research

Bifunctional Catalysis in the Stereocontrolled Synthesis of Tetrahydro-1,2-oxazines
This study demonstrates that the annulation of tetrahydro-1,2-oxazine ring can be realized via bifunctional catalysis employing nitoolefins and recently introduced group of aminooxylating reagents as starting materials. The developed cascade... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 9, 2017 Category: Molecular Biology Authors: Marek Moczulski Source Type: research

Concise Total Synthesis of (+)-Asperazine A and (+)-Pestalazine B
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02985C, CommunicationBrandon M. Nelson, Richard P. Loach, Stefan Schiesser, Mohammad Movassaghi The highly convergent total synthesis of dimeric diketopiperazine alkaloids (+)-asperazine A and (+)-pestalazine B is described. A critical aspect of our expedient route was the development of a directed regio-... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 9, 2017 Category: Molecular Biology Authors: Brandon M. Nelson Source Type: research

Synthesis of Azulene-substituted Benzofurans and Isocoumarins via Intramolecular Cyclization of 1-Ethynylazulenes, and their Structural and Optical Properties
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02861J, PaperTaku Shoji, Miwa Tabaka, Sho Takagaki, Kota Miura, Akira Ohta, Ryuta Sekiguchi, Shunji Ito, Shigeki Mori, Tetsuo Okujima Preparation of azulene-substituted benzofurans and isocoumarins was established by the two-types of intramolecular cyclization reaction of 1-ethynylazulenes. 2-(1-Azulenyl)- and 2,3-bis(1-azulenyl)benzofurans were prepared by the palladium-catalyzed cross-coupling reaction of 1-iodoazulenes with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 9, 2017 Category: Molecular Biology Authors: Taku Shoji Source Type: research

Gold Catalyzed Heck-Coupling of Arenediazonium o-Benzenedisulfonimides
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02624B, PaperStefano Dughera, Margherita Barbero Diazonium salts, and precisely arenediazonium o-benzenedisulfonimides, have been used for the first time as efficient electrophilic partners in gold catalyzed Heck-coupling reactions. The synthetic protocol was general, easy and gave... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 9, 2017 Category: Molecular Biology Authors: Stefano Dughera Source Type: research

An Intramolecular Tryptophan-Condensation Approach for Peptide Stapling
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02667F, CommunicationYen Li Eunice Hui, Bhimsen Rout, Yaw Sing Tan, Chandra Verma, Kok-Ping Chan, Charles W. Johannes Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein-protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at C2 position... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 9, 2017 Category: Molecular Biology Authors: Yen Li Eunice Hui Source Type: research

A coelenterazine-type bioluminescent probe for nitroreductase imaging
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02618H, PaperXingye Yang, Zhenzhen Li, Tianyu Jiang, Lupei Du, Minyong Li Novel coelenterazine-type bioluminescent probes have been designed and synthesized to detect nitroreductase (NTR) in hypoxic tumors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 8, 2017 Category: Molecular Biology Authors: Xingye Yang Source Type: research

Aerobic oxidative acylation of nitroarenes with arylacetic esters under mild conditions: facile access to diarylketones
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02865B, PaperJiang-Sheng Li, Qian Yang, Fan Yang, Guo-Qin Chen, Zhi-Wei Li, Yin-Jie Kuang, Wei-Jing Zhang, Peng-Mian Huang A regioselectivet-BuONa-mediated aerobic oxidative acylation of nitroarenes under mild conditions is developed through a cascade CDC/oxidative decarboxylation process. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 8, 2017 Category: Molecular Biology Authors: Jiang-Sheng Li Source Type: research

Intramolecular Nucleophilic Addition of Carbanions Generated from N-Benzylamides to Cyclopropenes
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02068F, PaperVladimir A Maslivetc, Colby Barrett, Nicolai A Aksenov, Marina Rubina, Michael Rubin Unusual reaction is described, involving a formal intramolecular nucleophilic substitution of bromocyclopropanes with nitrogen ylides generated in situ from N-benzyl carboxamides. It is shown that this reaction involves cyclopropene intermediates... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 8, 2017 Category: Molecular Biology Authors: Vladimir A Maslivetc Source Type: research

Thermally induced N-S bond insertion reaction of diazo compounds with N-sulfenylsuccinimides: synthesis of sulfides and mechanism studies
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02488F, PaperXiaolu Zhang, Yang Zheng, Lihua Qiu, Xinfang Xu A metal-freegem-functionalization reaction of diazo compoundsvia a formal N-S bond insertion process under mild conditions is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Xiaolu Zhang Source Type: research

The direct and highly diastereoselective synthesis of 3,4-epoxy-2-piperidones. Application to the total synthesis and absolute configurational assignment of 3[small alpha],4[small alpha]-epoxy-5[small beta]-pipermethystine
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02700A, PaperUrbano Osorio-Nieto, Laura Y. Vazquez-Amaya, Herbert Hopfl, Leticia Quintero, Fernando Sartillo-Piscil The substrate-controlled asymmetric total synthesis and absolute configurational assignment of biologically active 3[small alpha],4[small alpha]-epoxy-5[small beta]-pipermethystine is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Urbano Osorio-Nieto Source Type: research

Synthesis of 2-methylbenzoxazoles directly from N-phenylacetamides catalyzed by palladium acetate
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02566A, PaperBiying Wang, Chengfei Jiang, Jiasheng Qian, Shuwei Zhang, Xiaodong Jia, Yu Yuan A method to synthesize 2-methylbenzoxazoles directly fromN-phenylacetamides catalyzed by Pd(OAc)2 in moderate to excellent yields has been achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Biying Wang Source Type: research

Design and synthesis of a hybrid framework of indanone and chromane: total synthesis of a homoisoflavanoid, brazilane
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02758C, PaperJinwoo Kim, Ikyon Kim A chemical backbone of tetracyclic homoisoflavanoid natural products such as brazilin inspired us to design a new chemical scaffold, 6a,11b-dihydroindeno[2,1-c]chromen-7(6H)-one, which is a hybrid structure of indanone and chromane. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Jinwoo Kim Source Type: research

Negishi cross-couplings in the synthesis of amino acids
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02682J, Review ArticleWilliam D. G. Brittain, Steven L. Cobb The application of the Negishi cross-coupling reaction in the synthesis of amino acids is reviewed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: William D. G. Brittain Source Type: research

Metal-free electrophilic phosphination of electron-rich arenes, arenols and aromatic thiols with diarylphosphine oxides
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02620J, CommunicationTao Yuan, Shenlin Huang, Chun Cai, Guo-ping Lu A metal-free and mild route to aromatic organophosphorus compounds from stable phosphines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Tao Yuan Source Type: research

Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02386C, PaperMohamed S. A. Elsayed, Siran Chang, Mark Cushman A similarity search and molecular modeling study suggested the 2[prime or minute]-aryl-2-arylbenzothiazole framework as a novel scaffold for the design of COX-2-selective inhibitors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Mohamed S. A. Elsayed Source Type: research

Rh(III)-Catalyzed ortho-C-H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02438J, CommunicationSisheng Hu, Liang Lu, Tongyang Zhu, Qian Wu, Ying Chen, Jie Jack Li, Jing Zhao Directing group ONHR preservedortho-alkynylation under mild conditions catalyzed by rhodium is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Sisheng Hu Source Type: research

Diarylmaleimide-based branched oligomers: strong full-color emission in both solution and solid films
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02446K, PaperJingwei Wang, Rong Zheng, Huan Chen, Huimei Yao, Liyu Yan, Jie Wei, Zhenghuan Lin, Qidan Ling An effective design method is presented to construct highly efficient fluorescent materials in both solution and solid films, by non-conjugately linking fluorophores into branched oligomers. Surface aryl groups are changed to tune the luminescent color from blue ([small lambda]em = 480 nm) to red ([small lambda]em = 651 nm), and realize full-color emission. To cite this article before page numbers are assigned, use the DOI form of citation above. The content o...
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Jingwei Wang Source Type: research

Side Chain-specific 11/9-Helix Propensity of [small alpha]/[small beta]-Peptides with Alternating Residue Types
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02816D, PaperJaeyeon Lee, Jihyun Shim, Philjae Kang, Moon-Gun Choi, Soo Hyuk Choi The 11/9-helix is among most stable and non-traditional helical structures for [small alpha]/[small beta]-peptides with alternating residue types. The effect of side chain groups of [small alpha]-residues and [small beta]3-residues on the 11/9-helix propensity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Jaeyeon Lee Source Type: research

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02119D, CommunicationStefan Matysiak, Klaus Hellmuth, Afaf H. El-Sagheer, Arun Shivalingam, Yavuz Ariyurek, Marco de Jong, Martine J. Hollestelle, Ruud Out, Tom Brown DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Stefan Matysiak Source Type: research

A Bronsted acid-promoted asymmetric intramolecular allylic amination of alcohols
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02599H, CommunicationJianqiao Zhou, Hexin Xie Reported herein is a chiral Bronsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile synthesis of a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Jianqiao Zhou Source Type: research

A convergent synthesis of vinyloxyimidazopyridine via Cu(I)-catalyzed three-component coupling
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02883K, PaperAlakananda Hajra, Sadhanendu Samanta, Susmita Mondal Synthesis of vinyloxyimidazopyridine with complete regio and stereoselectivity has been achieved by the Cu(I)-catalyzed three-component coupling of 2-aminopyridine, 2-oxoaldehyde and alkyne. This protocol is operationally very simple and of much... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Alakananda Hajra Source Type: research

Nickel Catalyzed Acceptorless Dehydrogenative Approach to Quinolines
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02670F, PaperSeuli Parua, Rina Sikari, Suman Sinha, Siuli Das, Gargi Chakraborty , Nanda D Paul A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Seuli Parua Source Type: research

Synthesis of polysubstituted pyridines from oxime acetates using NH4I as a dual-function promoter
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02471A, PaperYujia Xia, Jinhui Cai, Huawen Huang, Guo-Jun Deng An NH4I dual-function promoter enables pyridine synthesis through oxime N-O bond reduction and subsequent condensation reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Yujia Xia Source Type: research

Narcissistic chiral self-sorting of molecular face-rotating polyhedra
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02727C, CommunicationXinchang Wang, Pixian Peng, Wei Xuan, Yu Wang, Yongbin Zhuang, Zhongqun Tian, Xiaoyu Cao Narcissistic chiral self-sorting prevailed in the assembly of molecular face-rotating polyhedra from aC3h building block 5,5,10,10,15,15-hexabutyl-truxene-2,7,12-tricarbaldehyde and racemic mixtures of 1,2-diamines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 7, 2017 Category: Molecular Biology Authors: Xinchang Wang Source Type: research