Electrochemical Regioselective C –H Selenylation of 2H-Indazole Derivatives
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02108G, CommunicationZhixiong Ruan, Shengsheng Lin, Xiaomei Cheng, Hasimujiang Balati, Zhongnan Xu, Fengtan Li The selenium-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a metal-and oxidant-free, environmentally friendly protocol for the regioselective selenylation of 2H-indazole derivatives... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 27, 2021 Category: Molecular Biology Authors: Zhixiong Ruan Source Type: research

Understanding Cu(II)-based systems for C(sp3) –H bond functionalization: insights on the synthesis of aza-heterocycles
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02118D, PaperMarc Camats, Isabelle Favier, Sonia Ladeira, Daniel Pla, Montserrat Gomez Herein we report the synthesis of imidazo[1,5-a]pyridine heterocycles via a Cu(II)-mediated functionalization of α’-C(sp3)–H bonds of pyridinylaldimines and subsequent cyclization. This strategy exploits the inherent directing ability of heteroleptic aldimine... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 27, 2021 Category: Molecular Biology Authors: Marc Camats Source Type: research

Nicked Invader probes: Multistranded and sequence-unrestricted recognition of double-stranded DNA
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02019F, PaperShiva P Adhikari, Saswata Karmakar, Patrick J. Hrdlicka Major efforts have been devoted to the development of constructs that enable sequence-specific recognition of double-stranded (ds) DNA, fueled by the promise for enabling tools for applications in molecular biology,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 27, 2021 Category: Molecular Biology Authors: Shiva P Adhikari Source Type: research

The role of streptavidin and its variants in catalysis by biotinylated secondary amines
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Alexander R. N ödling, Nicolò Santi, Raquel Castillo, Magdalena Lipka-Lloyd, Yi Jin, Louis C. Morrill, Katarzyna Świderek, Vicent Moliner, Louis Y. P. Luk Here, we combine the use of host screening, protein crystallography and QM/MM molecular dynamics simulations to investigate how protein enviroment affects iminium catalysis by biotinylated secondary amines in a model 1,4 conjugate addition reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Ro...
Source: RSC - Organic and Biomolecular Chemistry - November 26, 2021 Category: Molecular Biology Authors: Alexander R. N ödling Source Type: research

Addition of benzyl ethers to alkynes: a metal-free synthesis of 1H-isochromenes
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01941D, PaperTzu-Hsuan Kuan, Trimurtulu Kotipalli, Cheng-Chun Chen, Duen-Ren Hou The synthesis of 1H-isochromenes was achieved by addition of benzyl ethers to alkynes, activated with bromotrimethylsilane (TMSBr). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 26, 2021 Category: Molecular Biology Authors: Tzu-Hsuan Kuan Source Type: research

Conformation-Dependent Antioxidant Properties of β-Carotene
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01723C, PaperSandhiya Lakshmanan, Hendrik Zipse The antioxidant capacity of β-carotene has been studied in terms of H-atom abstraction reactions using quantum chemical methods. These oxidation reactions are studied for the all-trans as well as 15,15'-cis... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 26, 2021 Category: Molecular Biology Authors: Sandhiya Lakshmanan Source Type: research

Yb(OTf)3  Catalyzed [1,3]-Rearrangement of 3- Alkenyl Oxindoles
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02032J, CommunicationChaofei Wu, Junlin Wan, Chao Song, Lingchen He, Hongxin Liu, Xin-Hua Li, Juan Li, Xingen Hu, Hongping Xiao, Jun Jiang A Yb(OTf)3 catalyzed [1,3]-rearrangement of 3- alkenyl oxindoles was achieved, affording a variety of multifunctional 3-ylideneoxindoles with good yields and Z/E selectivities (64%-89% yield, 78:22->99:1 Z/E). Importantly, an operationally simple,  one-pot sequential... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 26, 2021 Category: Molecular Biology Authors: Chaofei Wu Source Type: research

Photocrosslinking of DNA using 4-methylpyranocarbazole nucleoside with thymine base selectivity
Org. Biomol. Chem., 2021,19,9860-9866 DOI: 10.1039/D1OB01621K, PaperJun-ichi Mihara, Kenzo Fujimoto MEPK can selectively photocrosslink to thymine bases in a complementary nucleic acid strand. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Jun-ichi Mihara Source Type: research

Green solvents for the formation of amide linkages
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01814K, Review ArticleDebora Procopio, Carlo Siciliano, Sonia Trombino, Denisa Elena Dumitrescu, Felicia Suciu, Maria Luisa Di Gioia Green solvents as alternatives for cleaner and safer amide synthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Debora Procopio Source Type: research

Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB02086B, PaperTakashi Mino, Yohei Fujisawa, Shizuki Yoshida, Mitsuru Hirama, Takumu Akiyama, Ryo Saito, Yasushi Yoshida, Yoshio Kasashima, Masami Sakamoto We have synthesized cinnamoyl amide type chiral P,olefin ligand and obtained separable diastereomers of4d and demonstrated Pd-catalyzed asymmetric allylic substitution reactions of indoles using this chiral ligand with high enantioselectivities (up to 98% ee). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (...
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Takashi Mino Source Type: research

Correction: Ruthenium(II)-catalyzed decarbonylative and decarboxylative coupling of isatoic anhydrides with salicylaldehydes: access to aryl 2-aminobenzoates
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Bidisha R. Bora, Rashmi Prakash, Sabera Sultana, Sanjib Gogoi To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Bidisha R. Bora Source Type: research

Simulations Reveal Key Role of Arg15 for Promiscuous Activity in HisA Enzyme
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02029C, PaperKshatresh Dutta Dubey, Warispreet Singh The HisA enzyme catalyzes the first step of histidine biosynthesis via Amadori rearrangement of substrate ProFAR. Since it possesses the most conserved and ancient TIM-barrel fold, it provides an ideal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Kshatresh Dutta Dubey Source Type: research

Design of novel tripyridinophane-based Eu(III) complexes as efficient luminescent labels for bioassays applications
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02092G, PaperNadine Leygue, Claude Picard, Pamela Faure, Emmanuel Bourrier, Laurent Lamarque, Jurriaan M Zwier, Chantal Galaup In this work, the development of high luminescent europium(III) complexes in water solution is reported, including their synthesis, analyses of their photophysical properties and applications in bioassays. The three Eu(III)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Nadine Leygue Source Type: research

Synthesis of illudalic acid and analogous phosphatase inhibitors
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02106K, PaperHarvey F. Fulo, Nicole J. Rueb, Robert Gaston, Jr., Paratchata Batsomboon, Kh Tanvir Ahmed, AM Barrios, Gregory Dudley Developing an efficient, concise synthesis of the fungal natural product illudalic acid has been a long-standing challenge, made more pressing by the recent discovery that illudalic acid and analogs are... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Harvey F. Fulo Source Type: research

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02040D, PaperChan Jiang, Mingfang Li, LEITAO XU, Yangjie Yi, Jiao Ye, Aixi Hu A convenient and efficient method for the generation of iminoxy radical through the anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from N-benzyl amidoximes. The transformation undergoes 1.5-Hydrogen... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Chan Jiang Source Type: research

Characterization of the low energy conformations and differential reactivities of D-glucose and D-mannose based oxepines
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01900G, PaperCaleb Griesbach, Mark Peczuh Carbohydrate-based oxepines are valuable intermediates for the synthesis of septanose carbohydrates. Here we report the characterization of the preferred conformations of D-glucose and D-mannose based oxepines 1 and 2 using... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 25, 2021 Category: Molecular Biology Authors: Caleb Griesbach Source Type: research

Transition metal catalysed direct construction of 2-pyridone scaffolds through C –H bond functionalizations
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01856F, Review ArticleSubarna Pan, Souradip Sarkar, Bidhan Ghosh, Rajarshi Samanta A summary of literature on transition metal catalysed construction of 2-pyridone scaffolds using a wide range of coupling partnersvia C –H bond functionalizations has been described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 24, 2021 Category: Molecular Biology Authors: Subarna Pan Source Type: research

Cobalt(III)-catalyzed C –H amidation of N,N-dialkyl thiobenzamides by sulfur coordination
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB02034J, CommunicationPengpeng Gao, Xiaohui Zhang, Qing-Zhong Zheng This amidation reaction proceeds with high functional group tolerance under external oxidant free conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 24, 2021 Category: Molecular Biology Authors: Pengpeng Gao Source Type: research

Dithiocarbamation of spiro-aziridine oxindoles: a facile access to C3-functionalised 3-thiooxindoles as apoptosis inducing agents
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02102H, PaperShankaraiah Nagula, Akash P Sakla, Biswajit Panda, Kritika Laxmikeshav, Jay Prakash Soni, Sonal Bhandari, Chandraiah Godugu Herein, we report the first dithiocarbamation of spiro-aziridine oxindoles involving regiospecific ring-opening by in situ generated nucleophilic dithiocarbamates as an instant source of sulfur. This approach afforded C3-functionalised-3-thiooxindoles in good... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 24, 2021 Category: Molecular Biology Authors: Shankaraiah Nagula Source Type: research

Polymeric Nanostructures Based on Azobenzene and Their Biomedical Application: Synthesis, Self-assembly and Stimuli-Response
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01823J, Review ArticleMingxin Zheng, Jinying Yuan Amphiphilic polymers can self-assemble to form nanoparticles with different structures under suitable conditions. Polymer nanoparticles functionalized with aromatic azo groups are endowed the photo-responsive properties. In recent years, a variety... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 24, 2021 Category: Molecular Biology Authors: Mingxin Zheng Source Type: research

Transition-metal catalyzed oxidative spirocyclization of N-aryl alkynamides with methylarenes under microwave irradiation
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01970H, PaperJin-Wei Yuan, Chen-Xu Mou, Yang Zhang, Wen-Yu Hu, Liang-Ru Yang, Yong-Mei Xiao, Pu Mao, Shou-Ren Zhang, Ling-Bo Qu A variety of 3-benzyl spiro[4,5]trienones were synthesized  via Cu/Ag-catalyzed ipso-annulation of alkynes with methylarenes using TBPB as an oxidant under microwave irradiation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Jin-Wei Yuan Source Type: research

Asymmetric synthesis of functionalized 2,3-dihydrobenzofurans using salicyl N-phosphonyl imines facilitated by group-assisted purification (GAP) chemistry
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB02078A, CommunicationHossein Rouh, Yao Tang, Sai Zhang, Ahmed I. M. Ali, Daniel Unruh, Kazimierz Surowiec, Guigen Li A new asymmetric method for the synthesis of highly functionalized 2,3-dihydrobenzofuranes in good to high yields and excellent diastereoselectivityvia group-assisted purification (GAP) chemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Hossein Rouh Source Type: research

A straightforward synthesis of functionalized 6H-benzo[c]chromenes from 3-alkenyl chromenes by intermolecular Diels –Alder/aromatization sequence
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01967H, PaperMarco Ballarotto, Mario Solinas, Andrea Temperini A new and metal-free approach to the synthesis of substituted 6H-benzo[c]chromenes has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Marco Ballarotto Source Type: research

Phosphorylation of Arenes, Heteroarenes, Alkenes, Carbonyls and Imines by Dehydrogenative Cross-Coupling of P(O)-H and P(R)-H
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02003J, Review ArticleSoumyadip Hore, Ravi Prakash Singh Organophosphorous has recently emerged as a powerful class of compounds with widespread applications such as bioactive natural products, pharmaceuticals, agrochemicals, organic materials and as ligands in catalysis. The preparation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Soumyadip Hore Source Type: research

Recent advances in palladium-catalyzed C(sp3)/C(sp2)-H bond functionalizations: Access to C-branched glycosides
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02142G, Review ArticlePintu Kumar Mandal, Zanjila Azeem Over the recent decades, tremendous interest has been developed involving the transformation of complex substrates by the C –H activation and functionalization. In particular, the palladium-catalyzed directing and non-directing group-assisted C-H... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Pintu Kumar Mandal Source Type: research

Spiro-based diamond-type nanogrids (DGs) via two ways: ‘A1B1’/‘A2 + B2’ type gridization of vertical spiro-based fluorenol synthons
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01907D, PaperYing Wei, Yang Li, Dongqing Lin, Dong Jin, Xue Du, Chunxiao Zhong, Ping Zhou, Yue Sun, Linghai Xie, Wei Huang Diamond-type nanogrids (DGs), can helically expand to form spiro-linked polymers. Herein, we designed and synthesized two types of DGs, DGs-1 (A1B1 mode) in 44 –50% yields, and DGs-2 (A2 + B2 mode) in 64% yield. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Ying Wei Source Type: research

Metal-free regioselective nitration of quinoxalin-2(1H)-ones with tert-butyl nitrite
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02015C, CommunicationZhen Wang, Yi-Na Li, Xue-Lin Li, Jin-Bo Wu, Hong Jiang, Yunmei Liu, Yu Guo, Yao-Fu Zeng A metal-free coupling of quinoxalin-2(1H)-ones with tert-butyl nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Zhen Wang Source Type: research

Synthesis of 5,7-diarylindoles via Suzuki –Miyaura coupling in water
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Vijayaragavan Elumalai, J ørn H. Hansen Straightforward access to a range of novel, fluorescent 5,7-diarylindolesvia Suzuki –Miyaura coupling. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Vijayaragavan Elumalai Source Type: research

Enantioselective Hydrophosphonylation of N-Boc Imines using Chiral Guanidine –Thiourea Catalysts
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01953H, CommunicationLouis Chassillan, Yasuhiro Yamashita, Woo-Jin Yoo, martial TOFFANO, R égis Guillot, Shu Kobayashi, Giang Vo-Thanh The enantioselective hydrophosphonylation of N-Boc imines was investigated using a new family of pseudo-symmetric guanidine –thiourea catalysts, providing -amino phosphonates in moderate to high yields with good enantioselectivity. The catalyst was... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Louis Chassillan Source Type: research

Two-Pot Synthesis and Photophysical Studies of 1,6-disubstituted 5-Aza-Indoles from Succinaldehyde and N-Aryl Propargylic-Imines
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01949J, PaperSatheeshvarma Vanaparthi, Mamta Mamta, Jyothi Yadav, Amol Prakash Pawar, Eldhose Iype, Sravendra Rana, Indresh Kumar A two-pot synthesis of 5-aza-indoles has been developed from aqueous succinaldehyde and N-aryl propargylic-imines. This overall protocol involves (i) metal-free [3+2] annulation between aqueous succinaldehyde and N-aryl propargylic-imines to access... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Satheeshvarma Vanaparthi Source Type: research

Copper(I)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02091A, CommunicationGuangzhe Li, Guo Yu, Chengdong Wang, Taiki Morita, Xuhai Zhang, Hiroyuki Nakamura Intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines1 with phosphite diesters2 proceeded in the presence of Cu(I)-catalysts (20mol%) to selectively give 2-phosphono-1,2,3,4-tetrahydroquinolines3 in good yields with 100% atomic utilization.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 23, 2021 Category: Molecular Biology Authors: Guangzhe Li Source Type: research

Copper-catalyzed cascade radical cyclization of alkynoates: construction of aryldifluoromethylated coumarins
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01754C, PaperPiaopiao Zeng, Xiaoxiao Huang, Wei Tang, Zhiwei Chen Synthesis of a variety of aryldifluoromethylated coumarins by cascade radical cyclization reactions in systems where alkynoates and α,α-difluoroarylacetic acids coexist, using (NH4)2S2O8 as oxidant and CuI as catalyst. The transformation was accomplished under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 22, 2021 Category: Molecular Biology Authors: Piaopiao Zeng Source Type: research

Chemical synthesis of 4 ′-thio and 4′-sulfinyl pyrimidine nucleoside analogues
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Mieke Guinan, Ningwu Huang, Chris S. Hawes, Marcelo A. Lima, Mark Smith, Gavin J. Miller Synthesis of 4-thioribose building blocks and related 4 ′-thio and 4′-sulfinyl nucleoside analogues. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 22, 2021 Category: Molecular Biology Authors: Mieke Guinan Source Type: research

Visible Light Mediated Synthesis of 6H-Benzo[c]chromenes: Transition-Metal-Free Intramolecular Direct C-H Arylation
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01673C, PaperMicaela Heredia, Marcelo Puiatti, Roberto A. Rossi, Mar ía E. Budén A synthetic approach towards 6H-benzo[c]chromene ring under visible light and transition-metal-free conditions has been developed. Benzochromenes are synthesized from the corresponding (2-halobenzyl) phenyl ethers or (2-halophenyl) benzyl ethers using KOtBu... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 22, 2021 Category: Molecular Biology Authors: Micaela Heredia Source Type: research

A Comprehensive Study on the Effect of Backbone Stereochemistry of a Cyclic Hexapeptide on Membrane Permeability and Microsomal Stability
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02090K, CommunicationYuki Hosono, Jumpei Morimoto, Shinsuke Sando Backbone stereochemistry of cyclic peptides has been reported to have a great influence on microsomal stability and membrane permeability, two important factors that determine oral bioavailability. Here, we comprehensively investigated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 22, 2021 Category: Molecular Biology Authors: Yuki Hosono Source Type: research

Recent development in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C=C-N donors
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01998H, Review ArticleXiao-Feng Xia, Yanning Niu Nitrogen-containing heterocycles are ubiquitous fragments of numerous natural products, pharmaceuticals, designed bioactive drug candidates and agrochemicals. During the past decades, these compounds have received considerable attention from the synthetic chemistry... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 20, 2021 Category: Molecular Biology Authors: Xiao-Feng Xia Source Type: research

Synthesis of 3-Halogenlated 2,3 ′-Biindoles by a Copper-mediated 2,3-Difunctionalization of Indoles
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02024B, PaperXiaoxiang Zhang, Yingying Zhang, Xiaoting Gu, Zhuan Zhang, Wanxing Wei, Taoyuan Liang A copper-mediated 2,3-difunctionalization of indoles to afford 3-halogenlated 2,3 ′-biindoles was described herein. The protocol uses readily available feedstocks and a naturally abundant copper catalyst system, which allows regioselective formation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 20, 2021 Category: Molecular Biology Authors: Xiaoxiang Zhang Source Type: research

Metal-free synthesis of 1H-isochromenes via benzyl ether-assisted, electrophilic addition of diaryl acetylenes
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01941D, PaperTzu-Hsuan Kuan, Trimurtulu Kotipalli, Cheng-Chun Chen, Duen-Ren Hou Bromotrimethylsilane (TMSBr) promoted, intramolecular cyclization of (o-arylethynyl)benzyl ethers to form 1H-isochromenes at room temperature is reported. Further studies indicated that the stability of vinyl carbocations is crucial, similar to the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 20, 2021 Category: Molecular Biology Authors: Tzu-Hsuan Kuan Source Type: research

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02014E, PaperSusumu Tsuda, Kaoru Asahi, Ryota Takahashi, Hiroki Yamauchi, Ryoji Ueda, Takanori Iwasaki, Shin-ichi Fujiwara, Nobuaki Kambe Transition-metal catalysts are powerful tools for carbon –carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widespread... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 19, 2021 Category: Molecular Biology Authors: Susumu Tsuda Source Type: research

Iron-Catalyzed Alkyne-Carbonyl Metathesis for the Synthesis of 6,7-Dihydro-5H-dibenzo[c,e]azonines
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01258D, CommunicationBaitan Chakraborty, Umasish Jana The synthesis of nine-membered rings via alkyne-carbonyl metathesis is reported. The alkyne and acetal units contained in a biaryl substrate undergo intramolecular alkyne-carbonyl metathesis reaction under FeCl3-catalysis to furnish the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 19, 2021 Category: Molecular Biology Authors: Baitan Chakraborty Source Type: research

Computational Studies on the Sterol-like Cyclization of the Monodomain Class II Terpene Cyclase
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB02018H, PaperB Andes Hess, Jr., J örn Piel, Lidia Smentek The proposed mechanism for the sterol-like cyclization of a monodomain class II terpene cyclase was studied computationally by using density functional theory (DFT). The complete pathway for the conversion of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 19, 2021 Category: Molecular Biology Authors: B Andes Hess, Jr. Source Type: research

Effective synthesis of novel dihydrobenzisoxazoles bearing 2-aminothiazole moiety and antiproliferative activity evaluation of their acylated derivatives
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01614H, PaperYuri A. Piven, Alexander M. Scherbakov, Margarita A. Yastrebova, Danila V. Sorokin, Yuri Yu. Shchegolev, Anton E. Matous, Veronica G. Zinovich, Tatyana S. Khlebnicova, Fedor A. Lakhvich Effective method of synthesis of 8-aryl-4,5-dihydrothiazolo[4',5':3,4]benzo[1,2-c]isoxazol-2-amines was developed. The method includes α-keto bromination of 3-aryl-6,7-dihydrobenzo[c]isoxazol-4(5H)-ones followed by condensation of obtained bromo derivatives with thiourea in acetonitrile with 92-98% yield. Using... The content of this RSS Feed (c) The Royal Soc...
Source: RSC - Organic and Biomolecular Chemistry - November 19, 2021 Category: Molecular Biology Authors: Yuri A. Piven Source Type: research

Synthesis of Indolo[2,1- α]isoquinoline Derivatives via Metal-free Radical Cascade Cyclization
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01917A, PaperJianzhong Chen, Hu Xu-yang, Haifeng Xu, Qiang Chen, You-lu Pan In the present studies, we described a convenient and efficient protocol for the synthesis of the indolo[2,1- ]isoquinoline core structure through the reaction of 2-aryl-N-acryloyl indoles and aryl or alkyl -keto... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 19, 2021 Category: Molecular Biology Authors: Jianzhong Chen Source Type: research

Transition-metal-free, one-pot synthesis of Benzoxaboroles from o-bromobenzaldehydes via visible-light-promoted borylation
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01853A, PaperJinghan Luo, Xingxing Jia, Yanjun Hu, Jianchao Chen, Tiemin Sun A novel and simple one-pot stepwise method to synthesize benzoxaboroles was demonstrated. This step-by-step synthetic method includes photocatalytic boronization with phenothiazine as photocatalyst and sequencely water-induced reduction in the presence... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 19, 2021 Category: Molecular Biology Authors: Jinghan Luo Source Type: research

Acridinone-based anion transporters
Org. Biomol. Chem., 2021,19,9659-9674 DOI: 10.1039/D1OB01545A, PaperDaniel A. McNaughton, Lauren K. Macreadie, Philip A. Gale The acridinone 1,9-bis(thio)urea scaffold was repurposed for application in anion transport by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved which facilitated strictly electroneutral transport. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 18, 2021 Category: Molecular Biology Authors: Daniel A. McNaughton Source Type: research

Molecular cages for biological applications
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Luc ía Tapia, Ignacio Alfonso, Jordi Solà This review compiles selected relevant examples of synthetic receptors defining a closed three-dimensional cavity (cages) with applications in chemical biology and biomedicine. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 18, 2021 Category: Molecular Biology Authors: Luc ía Tapia Source Type: research

Recent advances in the organocatalytic applications of cyclopropene- and cyclopropenium-based small molecules
Org. Biomol. Chem., 2021,19,9541-9564 DOI: 10.1039/D1OB01549D, Review ArticlePavit K. Ranga, Feroz Ahmad, Gurdeep Singh, Akshi Tyagi, Ramasamy Vijaya Anand A comprehensive discussion on the organocatalytic applications of cyclopropene-based small molecules such as cyclopropenium salts, cyclopropenimines, cyclopropenylidenes, and cyclopropenones in organic transformations is reported. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 18, 2021 Category: Molecular Biology Authors: Pavit K. Ranga Source Type: research

Hydrogen bonding interactions can decrease clar sextet character in acridone pigments
Org. Biomol. Chem., 2021,19,9619-9623 DOI: 10.1039/D1OB01720A, CommunicationZhili Wen, Lucas Jos é Karas, Judy I-Chia Wu Magnetic evaluations of aromaticity suggest that hydrogen bonding interactions can perturb the Clar sextet characters of acridones, which have implications for their electronic properties. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 18, 2021 Category: Molecular Biology Authors: Zhili Wen Source Type: research

Multi-fold Sonogashira coupling: a new and convenient approach to obtain tetraalkynyl anthracenes with tunable photophysical properties
Org. Biomol. Chem., 2021,19,9692-9704 DOI: 10.1039/D1OB01861B, PaperKhadimul Islam, Himani Narjinari, Akshara Bisarya, Akshai Kumar Nine new symmetric tetraalkynylated anthracenes have been synthesizedvia Pd(CH3CN)2Cl2/cataCXium ®A catalyzed tetra-fold Sonogashira coupling. Exciting photophysical properties are exhibited by these molecules in solution and in the solid-state. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 18, 2021 Category: Molecular Biology Authors: Khadimul Islam Source Type: research

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.
Org. Biomol. Chem., 2021,19,9637-9640 DOI: 10.1039/D1OB01927A, CommunicationShuai Liu, Cui-Shan Zhang, Xiao-Qian Ran, Xiao-Han Tang, Ya-Rong Guo, Ying Yan, Yong-Gang Yao, Xiao-Jiang Hao, Rong-Can Luo, Ying-Tong Di Two new quassinoids, perforalactones D and E, fromHarrisonia perforata, could promote the expression of lysosomal genes and induce lysosomal biogenesis. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 18, 2021 Category: Molecular Biology Authors: Shuai Liu Source Type: research