Rhodium(III)-catalysed Decarboxylative C –H Functionalization of Isoxazoles with Alkenes and Sulfoxonium Ylides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB02027C, CommunicationSomaraju Yugandar, Taiki Morita, Hiroyuki Nakamura Decarboxylative C-H functionalization of isoxazoles with electron-deficient alkenes and sulfoxonium ylides at the C5 position was achieved in the presence of rhodium(III) catalysts to give the corresponding alkenylation and acylmethylation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 20, 2020 Category: Molecular Biology Authors: Somaraju Yugandar Source Type: research

Metal-free C –S coupling of thiols and disulfides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01741H, Review ArticleMilan Pramanik, Khokan Choudhuri, Prasenjit Mal A literature overview on C –S coupling reactions using thiols or disulfides as sulfur surrogates under metal-free conditions is presented. Reagents for the transformations include polyvalent iodines, peroxides,tert-butyl nitrite (TBN), DDQ, and aerial oxygen, among others. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 19, 2020 Category: Molecular Biology Authors: Milan Pramanik Source Type: research

The catalyst-free decarboxylative dearomatization of isoquinolines with β-keto acids and sulfonyl chlorides in water: access to dihydroisoquinoline derivatives
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01799J, PaperYutong Zhang, Fuzhong Han, Lina Jia, Xiangping Hu An efficient and concise catalyst-free one-pot synthetic protocol for obtaining dihydroisoquinoline derivatives has been developedvia the three-component condensation of isoquinolines with β-keto acids and sulfonyl chlorides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 19, 2020 Category: Molecular Biology Authors: Yutong Zhang Source Type: research

NaHSO4/SiO2 catalyzed generation of o-quinone/ o-thioquinone methides: synthesis of arylxanthenes/ arylthioxanthenes via oxa-6 π-electrocyclization
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01868F, PaperMuthupandi Karthick, Edwin Konikkara Abi, Nagamalla Someshwar, Savarimuthu Philip Anthony, Chinnasamy Ramaraj Ramanathan Arylxanthenes/arylthioxanthenes, with a hydride donor and turn-on fluorescence properties, have been synthesized efficiently from 2-(hydroxydiarylmethyl)phenols/thiophenols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 19, 2020 Category: Molecular Biology Authors: Muthupandi Karthick Source Type: research

Synthesis of difluoroalkylated 2-azaspiro[4.5]decane derivatives via copper-catalyzed difluoroalkylation/dearomatization of N-benzylacrylamides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01833C, CommunicationChengwen Li, Yilin Zhao, Jiaxin Zhou, Xue Wang, Jingli Hou, Yuguang Song, Wenjuan Liu, Guifang Han A copper-catalyzed synthesis of difluoroalkylated spiro-azacycles fromN-benzylacrylamides is presented. The reaction involves the β-difluoroalkylation of acrylamide, 5-exo cyclization, and dearomatization. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 19, 2020 Category: Molecular Biology Authors: Chengwen Li Source Type: research

Palladium-catalyzed C-glycosylation and annulation of o-alkynylanilines with 1-iodoglycals: convenient access to 3-indolyl-C-glycosides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01812K, CommunicationJianchao Liu, Xiao Xiao, Puren Han, Huiwen Zhou, Qi-Shuang Yin, Jian-Song Sun An efficient and practical approach for the synthesis of 3-indolyl-C- ∆1,2–glycosides through a palladium-catalyzed annulation/C-glycosylation sequence of o-alkynylanilines with 1-iodoglycals has been developed. This methodology has a wide scope of substrates... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 19, 2020 Category: Molecular Biology Authors: Jianchao Liu Source Type: research

Photocatalyzed reductive fluoroalkylation of 2-acetoxyglycals towards the stereoselective synthesis of α-1-fluoroalkyl-C-glycosyl derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01914C, PaperErwin W. Mora Flores, Mar ía Laura Uhrig, Al Postigo A benign, efficient, regio- and stereoselective protocol for the syntheses of 1-fluoroalkyl-C-glycosyl compounds bearing CF3, C4F9, and C6F13 substituents on the anomeric carbon has been developed by a new methodology... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 19, 2020 Category: Molecular Biology Authors: Erwin W. Mora Flores Source Type: research

Radical cyclizations of enynes/dienes with alcohols in water using a green oxidant
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01902J, PaperDong-Kai Wang, Yi-Lin Fang, Jian Zhang, Yu-Tao Guan, Xun-Jie Huang, Jianfeng Zhang, Qiang Li, Wen-Ting Wei A simple, eco-friendly, and efficient methodology for performing radical cyclizations of enynes/dienes with alcohols in water has been established. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2020 Category: Molecular Biology Authors: Dong-Kai Wang Source Type: research

Ruthenium-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles via C–H/N–H bond functionalizations
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01899F, PaperZhangpei Chen, Zhiqiang Ding, Tian Chen, Lingxin Meng, Gongshu Wang An efficient method for the construction of various pyrazolo[5,1-a]isoquinolines has been achievedvia Ru(II)-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2020 Category: Molecular Biology Authors: Zhangpei Chen Source Type: research

C −H Functionalization of Organic Cations: An Interesting and Young Journey
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01453B, Review ArticleYu Yu, Hongxu Lv, Shiqing Li Organic ionic compounds, especially for those with organic cations, are commonly applied to ionic liquids (ILs), organocatalysts, (a)NHC ligands, ion recognition, and optoelectronic materials. Direct C −H functionalization of organic cations... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2020 Category: Molecular Biology Authors: Yu Yu Source Type: research

Probing versatility of metallo-electro hybrid catalysis: Enabling access towards facile C-N bond formation
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01874K, Review ArticleSudipta Raha Roy, Partha Pratim Sen, NEHA DAGAR, VISHALI PATHANIA, VISHAL JYOTI ROY, SWATI SINGH The development of versatile and mild methodologies for the C-N bond construction has always been a hot topic of interest in synthetic organic chemistry. In recent years, electrochemistry has emerged... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2020 Category: Molecular Biology Authors: Sudipta Raha Roy Source Type: research

Transition Metal Free Synthesis of Alkyl Pinacol Boronates
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01721C, Review ArticleSantanu ​ Panda, Kanak Kanti Das, Swagata Paul Alkyl boronic esters have been routinely used for the synthesis of complex target molecules or high value chemicals. Transition metal free synthesis of C-B bond has gained lot of interest... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2020 Category: Molecular Biology Authors: Santanu ​ Panda Source Type: research

FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01790F, PaperChinnakuzhanthai Gangadurai, Giri Teja Illa, D. Srinivasa Reddy An iron catalyzed one-pot, environmentally benign protocol for the oxidative decarboxylation of aryl/heteroaryl acetic acids to synthesize corresponding carbonyl compounds and five important API impurities is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Chinnakuzhanthai Gangadurai Source Type: research

Experimental and computational evidence on gold-catalyzed regioselective hydration of phthalimido-protected propargylamines: an entry to β-amino ketones
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01598A, PaperVincenzo Marsicano, Antonio Arcadi, Massimiliano Aschi, V éronique Michelet Gold-catalyzed regioselective hydration of phthalimido-protected propargylamines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Vincenzo Marsicano Source Type: research

Greener liquid-phase synthesis and the ACE inhibitory structure –activity relationship of an anti-SARS octapeptide
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01948H, PaperHaidi Li, Jin Ren, Junyou Li, Zixin Zhang, Ninghui Chang, Chuanguang Qin Tri(4 ′-diphenylphosphonyloxylbenzoyl phenyl)phosphate (TDPBP) derivatives were developed as greener supports to aid high-efficiency liquid-phase peptide synthesis without the need for unrecyclable resin and tedious chromatographic separation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Haidi Li Source Type: research

Medium-firm drug-candidate library of cryptand-like structures on T7 phage: Design and selection of strong binder for Hsp90
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01855D, CommunicationKazuto Mochizuki, Lisa Matsukura, Yuji Ito, Naoyuki Miyashita, Masumi Taki We designed and synthesized a medium-firm drug-candidate library of cryptand-like structures possessing randomized peptide linker on bacteriophage T7. From the macrocyclic library with 10^9 diversity, we obtained a binder toward... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Kazuto Mochizuki Source Type: research

Integrating abiotic chemical catalysis and enzymatic catalysis in living cells
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01898H, Review ArticleChristopher Adamson, Motomu Kanai Life emerges from networks of multiple chemical reactions mediated by enzymes. If abiotic chemical catalysis is implanted into the reaction network of life, such an integration would produce organisms generating... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Christopher Adamson Source Type: research

β-Borylation of Conjugated Carbonyl Compounds by Silylborane or Bis(pinacolato)diboron Catalyzed by Au Nanoparticles
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Manolis Stratakis, Marios Kidonakis, Michael Fragkiadakis Conjugated aldehydes and ketones undergo reaction with Me2PhSiBpin (pin: pinacolato) catalyzed by Au nanoparticles supported on TiO2 forming exclusively the β-borylation products, via intermediate formation of the labile silaboration adducts.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Manolis Stratakis Source Type: research

Catalyst-free construction of spiro [benzoquinolizidine-chromanones] via a tandem condensation/1,5-hydride transfer/cyclization process
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01887B, CommunicationSiyuan Liu, Hang Wang, Baomin Wang A catalyst-free tandem 1,5-hydride shift/cyclization process to form spiro [benzoquinolizidine-chromanones] is developed, which features high atom- and step-economy, high levels of stereocontrol, mild conditions, and simple workup process. A series... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 15, 2020 Category: Molecular Biology Authors: Siyuan Liu Source Type: research

Archromones A –F, unusual polycyclic dearomatic geranylquinol derivatives from the roots of Arnebia euchroma
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01934H, PaperHai-Wei Yan, Xu Zhang, Ya-Nan Yang, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang New geranylquinol derivatives possessing an unprecedented dearomatic benzocogeijerene skeleton from the roots ofArnebia euchroma and their cytotoxic activities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 14, 2020 Category: Molecular Biology Authors: Hai-Wei Yan Source Type: research

Total chemical synthesis of the phosphorylated p62 UBA domain reveals that Ser407Pi but not Ser403Pi enhances ubiquitin binding
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01906B, PaperLing Xu, Yan Zhang, Yi-Ming Li, Xian-Fu Lu As an autophagic adaptor, p62 specifically targets ubiquitinated proteins to the autophagosome for lysosomal degradation through a critical ubiquitin-associated (UBA) domain. Recent researches reported that Ser403 and Ser407 sites on... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 14, 2020 Category: Molecular Biology Authors: Ling Xu Source Type: research

Metal free decarboxylative aminoxylation of carboxylic acids using a biphasic solvent system
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01773F, PaperAndreas Kirschning, G öran Schulz The smooth oxidative radical decarboxylation of carboxylic acids with TEMPO and other derivatives as radical scavengers is reported. The key to success was the use of a two-phase solvent system... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2020 Category: Molecular Biology Authors: Andreas Kirschning Source Type: research

A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Dragan Zlatkovi ć, Doris Dallinger, C. Oliver Kappe Flash vacuum pyrolysis of methylN-methyl-N-nitrosoanthranilate leads to elimination of nitric oxide and disproportionation of the formed N-radical to 7-(methylamino)phthalide and methylN-methylanthranilate. This transformation was found to be a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2020 Category: Molecular Biology Authors: Dragan Zlatkovi ć Source Type: research

Functionalized fluorescent terephthalate monomers and their attempted polyester formation
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yvonne Shuen Lann Choo, Marta Giamberini, Jose Reina, Paul G Waddell, A. C. Benniston The reaction of diethyl 2,5-bis(tert-butyl)phenoxy)-3,6-dihydroxyterephthalate (1) with tetraethylene glycol di(p-toluenesulfonate under high-dilution conditions afforded several isolated products. Two products were identified as macrocycles with one being the 1+1 crown ether... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2020 Category: Molecular Biology Authors: Yvonne Shuen Lann Choo Source Type: research

Copper-Catalysed Radical Reactions of Alkenes, Alkynes and Cyclopropanes with N-F Reagents
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01743D, Review ArticleJos é María Muñoz-Molina, Tomás R. R. Belderrain, Pedro J. Perez The mild generation of nitrogen-centred radicals from N-F reagents has become a convenient synthetic tool. This methodology provides access to the aminative difunctionalisation of alkenes and alkynes, and the radical... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2020 Category: Molecular Biology Authors: Jos é María Muñoz-Molina Source Type: research

An ATP responsive fluorescent supramolecular assembly based on a polyelectrolyte and an AIE active tetraphenylethylene derivative
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01661F, PaperVidya R. Singh, Jotiram N. Malegaonkar, Sidhanath V. Bhosale, Prabhat K. Singh A supramolecular assembly is constructed using an anionic AIE active probe and a cationic polyelectrolyte to sense ATP fluorimetrically in solution. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2020 Category: Molecular Biology Authors: Vidya R. Singh Source Type: research

Transition Metal Catalyzed Glycosylation Reactions – An Overview
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01782E, Review ArticleEike B. Bauer Carbohydrates are a large class of natural products that play key roles in a number of biological processes like in cellular communication or disease progression. Carbohydrates are also used as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2020 Category: Molecular Biology Authors: Eike B. Bauer Source Type: research

Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01550D, Review ArticleTaleb H. Al-Tel, Vunnam Srinivasulu, Mani Ramanathan, Nelson C. Soares, Anusha Sebastian, Maria L. Bolognesi, Imad A. Abu-Yousef, Amin Majdalawieh Multi-divergent transformations of cyclohexadienone derivatives for the synthesis of stereoenriched and complex architectures. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2020 Category: Molecular Biology Authors: Taleb H. Al-Tel Source Type: research

Synthesis of α-aminooxy amides through [3 + 3] cycloaddition and Sc(OTf)3-catalyzed double C–N bond cleavage in a one-pot reaction
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01788D, PaperYan Luo, Chun-Hua Chen, Fan Zhu, Dong-Liang Mo A [3 + 3] cycloaddition and Sc(OTf)3-catalyzed double C –N bond cleavage to synthesize various α-aminooxy amides bearing a quaternary carbon in one pot have been achieved fromN-vinyl nitrones and α-bromohydroxamates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2020 Category: Molecular Biology Authors: Yan Luo Source Type: research

Bifunctional metal –organic frameworks for the hydrogenation of nitrophenol using methanol as the hydrogen source
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01686A, PaperArianna Melillo, Cristina Garc ía-Vallés, Belén Ferrer, Mercedes Álvaro, Sergio Navalón, Hermenegildo García This work reports the reduction of 4-nitrophenol to 4-aminophenol using UiO-66(Zr) as a bifunctional photocatalyst and hydrogenation catalyst using methanol as the hydrogen source. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2020 Category: Molecular Biology Authors: Arianna Melillo Source Type: research

Rhodium-catalyzed synthesis of substituted isoquinolones via a selective decarbonylation/alkyne insertion cascade of phthalimides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01793K, PaperFen Xu, Wen-Jing Zhu, Juan Wang, Qi Ma, Li-Jing Shen A rhodium-catalyzed decarbonylation/alkyne insertion cascade of phthalimides with alkynes has been established. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2020 Category: Molecular Biology Authors: Fen Xu Source Type: research

Synthesis of Difluoroalkylated 2-Azaspiro[4.5]decanes Derivatives via Copper-Catalyzed Difluoroalkylation/ Dearomatization of N-Benzylacrylamides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01833C, CommunicationChengwen Li, Yilin Zhao, Jiaxin Zhou, Xue Wang, jingli hou, Yuguang Song, Wenjuan Liu, Guifang Han An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes via copper-catalyzed difluoromethylation of N-benzylacrylamides with ethyl bromodifluoroacetate has been established. The reaction experienced a tandem radical addition, dearomatizating cyclization process.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2020 Category: Molecular Biology Authors: Chengwen Li Source Type: research

Asymmetric vinylogous Michael addition of 5-substituted-furan-2(3H)-ones to α,β-unsaturated-γ-lactam
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01750G, CommunicationMarta Romaniszyn, Les ław Sieroń, Lukasz Albrecht The manuscript describes an utilization of 5-substituted-furan-2(3H)-ones as pronucleophiles in an asymmetric vinylogous Michael addition to α,β-unsaturated-γ-lactam, thus leading to hybrid molecules possessing γ-lactam and butenolide structural motifs. The transformation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2020 Category: Molecular Biology Authors: Marta Romaniszyn Source Type: research

Base-mediated 1,3-dipolar cycloaddition of pyridinium bromides with bromoallyl sulfones: A facile access to indolizine scaffolds
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01696A, PaperAhmed Kamal, Chetna Jadala, Velma Ganga Reddy, Hari Krishna Namballa , Shankaraiah Nagula An expedient and transition-metal-free synthetic strategy has been developed for the construction of substituted indolizines from a unique combination of pyridinium salts and 2-bromoallyl sulfones. This approach does not compromise... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2020 Category: Molecular Biology Authors: Ahmed Kamal Source Type: research

Thiophene-based water-soluble fullerene derivatives as highly potent antiherpetic pharmaceuticals
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01826K, PaperOlga Kraevaya, Alexander S Peregudov, Natalia E Fedorova, Regina R Klimova, Ivan A. Godovikov, Denis Mischenko, Alexander F. Shestakov, Dominique Schols, Alla A Kushch, Pavel Troshin Here we report Friedel-Crafts arylation of chlorofullerenes C60Cl6 and C70Cl8 with thiophene-based methyl esters. While C60Cl6 formed expected Cs-C60R5Cl products, C70Cl8 demonstrated a tendency to both substitution of chlorine atoms... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2020 Category: Molecular Biology Authors: Olga Kraevaya Source Type: research

An optimized protocol for the synthesis of N-2-hydroxybenzyl-cysteine peptide crypto-thioesters
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01737J, PaperSkander A. Abboud, Vincent Aucagne Deciphering the formation of side-products during the synthesis ofN-Hnb-Cys crypto-thioesters led to the development of an automatable optimized protocol. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: Skander A. Abboud Source Type: research

NaHSO4/SiO2 catalyzed generation of o-quinone/o-thioquinone methides: Synthesis of arylxanthenes/arylthioxanthenes via oxa-6 π-electrocyclization
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01868F, PaperC. R. Ramanathan, Muthupandi Karthick, Edwin Konikkara Abi, Someshwar Nagamalla, Philip Philip Anthony ortho-Quinone methides, very reactive transient intermediates, are utilized successfully in synthesizing complex organic molecules of natural and biological significance. Among several synthetic protocols, the acid catalyzed generation of ortho-quinone methides... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: C. R. Ramanathan Source Type: research

Ruthenium-Catalyzed α-Carbonyl Sulfoxonium Ylides Annulations with Aryl Substituted Pyrazoles via C–H/N–H Bond Functionalizations
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01899F, PaperZhang-Pei Chen, Zhiqiang Ding, Tian Chen, Lingxin Meng, Gongshu Wang An efficient method for construction of various pyrazolo[5,1-a]isoquinolines has been achieved via Ru(II)-catalyzed α-carbonyl sulfoxonium ylides annulation with aryl substituted pyrazoles. This oxidant-free transformation occurred through pyrazole-directed C-H activation, Ru-carbene... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: Zhang-Pei Chen Source Type: research

Kinase and GPCR polypharmacological approach for the identification of efficient anticancer medicines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01917H, PaperH Park, Hoi-Yun Jung, Shinmee Mah, Kewon Kim, Sungwoo Hong Discovery of an anticancer medicine using a single target protein has often been unsuccessful due to the complexity of pathogenic mechanisms as well as the presence of redundant signaling pathways.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: H Park Source Type: research

Intrinsic Fluorescence Properties of Antimalarial Pyrido[1,2-a]benzimidazoles Facilitate Subcellular Accumulation and Mechanistic Studies in the Human Malaria Parasite Plasmodium falciparum
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01730B, PaperConstance Mawunyo Korkor, Larnelle Faye Garnie, Leah Amod, Timothy J Egan, Kelly Chibale The intrinsic fluorescence properties of two related pyrido[1,2-a]benzimidazole antimalarial compounds suitable for cellular imaging of the human malaria parasite Plasmodium falciparum without the need to attach extrinsic fluorophores are described.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: Constance Mawunyo Korkor Source Type: research

Systematic Synthesis of Novel Phosphoglycolipid Analogues as Potential Agonists of GPR55
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01756F, Paperjunpei abe, Adam T. Guy, Feiqing Ding, Peter Greimel, Yoshio Hirabayashi, Hiroyuki Kamiguchi, Yukishige Ito Rhodopsin like G protein-coupled receptor (GPCR) GPR55 is attracting attention as a pharmaceutical target, because of its relationship with various physiological and pathological events. Although GPR55 was initially deorphanized as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: junpei abe Source Type: research

Total synthesis of thioamycolamide A via a biomimetic route
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01942A, CommunicationChengqian Pan, Takefumi Kuranaga, Hideaki Kakeya A concise total synthesis of thioamycolamide A was accomplished as a key step of thio-Michael additionvia a biomimetic route. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: Chengqian Pan Source Type: research

Visible Light Photocatalytic Cross-Coupling and Addition Reactions of Arylalkynes with Perfluoroalkyl Iodides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01767A, PaperYelan Xiao, Yuen-Kiu Chun, Shun-Cheung Cheng, Ruoyang Liu , Man-Kit Tse, Chi-Chiu Ko Visible light photocatalytic cross-coupling and addition reactions of arylalkynes with perfluoroalkyl iodides have been developed. Through slight modification of the reaction conditions, reactions that are selective for the preparation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2020 Category: Molecular Biology Authors: Yelan Xiao Source Type: research

Conversion of aryl carboxylic acids into aryl nitriles through multi-versions of Cu-mediated decarboxylative cyanation under aerobic conditions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01945C, CommunicationZhengjiang Fu, Xihan Cao, Shuiliang Wang, Sheng Mei Guo, Hu Cai Using malononitrile or AMBN as cyanating agent, efficient and practical protocols for Cu-mediated decarboxylative cyanation of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 8, 2020 Category: Molecular Biology Authors: Zhengjiang Fu Source Type: research

Catalyst-Free Decarboxylative Dearomation of Isoquinolines with β-Keto Acids and Sulfonyl Chlorides in Water: Access to Dihydroisoquinoline Derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01799J, PaperYutong Zhang, Fuzhong Han, Jia Lina, Xiang-Ping Hu An efficient and concise catalyst-free one-pot synthetic protocol of dihydroisoquinoline derivatives has been developed by a three-component condensation of isoquinolines with β-keto acids and sulfonyl chlorides. This transformation of decarboxylative... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 8, 2020 Category: Molecular Biology Authors: Yutong Zhang Source Type: research

Visible-light-enabled aerobic oxidative Csp3 –H functionalization of glycine derivatives using an organic photocatalyst: access to substituted quinoline-2-carboxylates
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01837F, PaperJingxin Wang, Liqi Li, Ying Guo, Shengyu Li, Shutao Wang, Ying Li, Yuan Zhang A metal-free visible-light-induced aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with olefins has been developed to efficiently synthesize quinoline-2-carboxylates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 7, 2020 Category: Molecular Biology Authors: Jingxin Wang Source Type: research

Palladium-catalyzed double coupling reaction of terminal alkynes with isocyanides: a direct approach to symmetrical N-aryl dialkynylimines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01604G, CommunicationZhi-Wei Xi, Yan He, Li-Qiu Liu, Ying-Chun Wang We have synthesized symmetrical  N-aryl  dialkynylimines via the palladium-catalyzed double coupling reaction of terminal alkynes with isonitriles, and the obtained dialkynylimines could be readily converted into 2-iodobenzo[f]quinoline derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 7, 2020 Category: Molecular Biology Authors: Zhi-Wei Xi Source Type: research

Potassium tert-butoxide mediated C –C, C–N, C–O and C–S bond forming reactions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01382J, Review ArticleJayashree Madasu, Shital Shinde, Rudradip Das, Sagarkumar Patel, Amit Shard Potassium tertiary butoxide (KOtBu) mediated constructions of C –C, C–O, C–N, and C–S bonds are reviewed with special emphasis on their synthetic applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 6, 2020 Category: Molecular Biology Authors: Jayashree Madasu Source Type: research

TDPBP Derivative Aiding Liquid-Phase Synthesis Strategy and ACEI Structure-activity Relationship of Anti-SARS Octapeptide
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01948H, PaperHaidi Li, Jin Ren, Junyou Li, Zixin Zhang, Ninghui Chang, Chuanguang Qin The tri(4'-diphenylphosphonyloxylbenzoyl phenyl) phosphate (TDPBP) derivatives were designed and developed as C-terminal supports to aid the greener and high-efficient liquid-phase peptide synthesis (LPPS) without the need of unrecyclable resin and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 6, 2020 Category: Molecular Biology Authors: Haidi Li Source Type: research

Archromones A −F, Unusual Polycyclic Dearomatic Geranylquinol Derivatives from the Roots of Arnebia euchroma
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01934H, PaperHaiwei Yan, Xu Zhang, Ya-nan Yang, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang Eight new geranylquinol derivatives (1−8) were purified from the roots ofArnebia euchroma. Compounds1−6 possess unprecedented dearomatic benzocogeijerene skeleton with a raretrans-fused hydronaphthalene moiety. Their structures and absolute... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 6, 2020 Category: Molecular Biology Authors: Haiwei Yan Source Type: research