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Synthesis of carbazole-based BODIPY dimers showing red fluorescence in the solid state
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02419C, CommunicationChihiro Maeda, Takumi Todaka, Tomomi Ueda, Tadashi Ema Carbazole-based BODIPY dimers2a-g were synthesizedvia direct arylation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 17, 2017 Category: Molecular Biology Authors: Chihiro Maeda Source Type: research

Synthesis and Biological Applications of Fluoro-Modified Nucleic Acids
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02094E, Review ArticleFengmin Guo, Qiang Li, Chuanzheng Zhou Owe to the unique physical properties of a fluorine atom, incorporating fluoro-modifications into nucleic acids offers striking biophysical and biochemical features, and thus significantly extends the breadth and depth of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 17, 2017 Category: Molecular Biology Authors: Fengmin Guo Source Type: research

N- to C-sulfonyl photoisomerisation of dihydropyridinones: a synthetic and mechanistic study
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Pei-Pei Yeh, James E. Taylor, Daniel G. Stark, David S. B. Daniels, Charlene Fallan, John C. Walton, Andrew D. Smith The scope and limitations of a photoinitiatedN- toC-sulfonyl migration process within a range of dihydropyridinones is assessed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: Pei-Pei Yeh Source Type: research

A cryptophane-based "turn-on" 129Xe NMR biosensor for monitoring calmodulin
We present the first cryptophane-based "turn-on" 129Xe NMR biosensor, employing a peptide-functionalized cryptophane to monitor the activation of calmodulin (CaM) protein in solution. In the absence of CaM binding, interaction... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: Brittany A Riggle Source Type: research

One-pot synthesis of quinolines via Co(III)-catalyzed C-H activation/carbonylation/cyclization of anilines
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02310C, Communicationxuefeng xu, yurong yang, Xin Chen, Xu Zhang, Wei Yi We herein disclose a novel Co(III)-catalyzed C-H activation/carbonylation/cyclization of anilines with ketones using paraformaldehyde as the carbonyl source, giving direct access to diverse quinolines with broad functional group tolerance and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: xuefeng xu Source Type: research

Novel [small alpha]-Amino Acid-derived Phase-Transfer Catalysts Application to Highly Enantio-and diastereoselective Nitro-Mannich Reaction
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02501G, Paperyuxin liu, Zhonglin Wei, Yu Liu, Jungang Cao, Dapeng Liang, Yingjie Lin, haifeng duan The new quaternary ammonium type of bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors derived from [small alpha]-amino acids were readily prepared and found to be highly efficient in asymmetric nitro-Mannich... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: yuxin liu Source Type: research

Asymmetric acetate-Mannich reaction of chiral isatin derived ketimines and its applications
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02407J, PaperSaumen Hajra, Suhas Shivajirao Bhosale, Atanu Hazra A highly efficient TMSOTf-mediated asymmetric acetate-Mannich reaction of isatin derived tert-butylsulfinyl ketimines and S-phenyl thioacetate was developed to afford the direct synthesis of indole-based [small beta]3,3-amino acid thioester with excellent selectivity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: Saumen Hajra Source Type: research

Copper Catalyzed Oxidative Homocoupling of Terminal Alkynes to 1,3-Diynes: Cu3(BTC)2 MOF as an Efficient and Ligand Free Catalyst for Glaser-Hay Coupling
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02196H, PaperDEVARAJAN NAINAMALAI, KARTHIK MURUGAN, Suresh Palaniswamy A straightforward and efficient method has been demonstrated for the oxidative coupling of terminal alkynes using simple Cu3(BTC)2-Metal Organic Framework as a sustainable heterogeneous copper catalyst. A series of symmetrical... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: DEVARAJAN NAINAMALAI Source Type: research

Extreme halophilic alcohol dehydrogenase mediated highly efficient syntheses of enantiopure aromatic alcohols
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02299A, PaperDiya Alsafadi, Safaa Alsalman, Francesca Paradisi Enzymatic synthesis of enantiopure aromatic secondary alcohols (including substituted, hetero-aromatic and bicyclic structures) were carried out using the halophilic alcohol dehydrogenase ADH2 fromHaloferax volcanii (HvADH2). This enzyme showed an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 16, 2017 Category: Molecular Biology Authors: Diya Alsafadi Source Type: research

Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01920C, PaperSaswata Karmakar, Dale C Guenther, Bradley C Gibbons, Patrick J. Jerzy Hrdlicka Development of hybridization-based probes that enable recognition of specific mixed-sequence double-stranded DNA (dsDNA) regions is of considerable interest due to their potential applications in molecular biology, biotechnology, and medicine. We... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 14, 2017 Category: Molecular Biology Authors: Saswata Karmakar Source Type: research

Progressive Structural Modification to a Zinc-Actuated Photoinduced Electron Transfer (PeT) Switch in the Context of Intracellular Zinc Imaging
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02235B, PaperMiguel Macias-Contreras, Kirsten Daykin, Tyler Simmons, John Allen, Zachary Hooper, Michael Davidson , Lei Zhu Photoinduced electron transfer (PeT)-type fluorescent molecular switches are often applied in ion-selective sensors. Zinc-targeting sensors that contain an anilino-based electron donor (aka, the PeT 'switch') have multiple advantages over those... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 14, 2017 Category: Molecular Biology Authors: Miguel Macias-Contreras Source Type: research

Substoichiometric ribose methylations in spliceosomal snRNAs
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02317K, CommunicationNicolai Krogh, Martin Kongsbak-Wismann, Carsten Geisler, Henrik Nielsen Sequencing-based profiling of ribose methylations is a new approach that allows for experiments adrressing dynamic changes on a large scale. Here, we apply such a method to spliceosomal snRNAs present... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 14, 2017 Category: Molecular Biology Authors: Nicolai Krogh Source Type: research

A Facile Access to functionalized Indenes and Fused Quinolines by Regioselective 5-enolexo-dig Michael Addition and Cyclization Reaction
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02498C, PaperVibha Tandon, Tohasib Yusub Chaudhari, Sandeep K. Ginotra Herein we reported a facile approach to multi-substituted indenes and cyclopenta[b]quinolines under mild conditions. The reaction proceeds via Michael addition between commercially available cyanoacetate/malonic esters and [small alpha],[small beta]-unsaturated ketones. The synthetic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2017 Category: Molecular Biology Authors: Vibha Tandon Source Type: research

NHC-catalyzed regiodivergent syntheses of difunctionalized 3-pyrazolidinones from [small alpha]-bromoenal and monosubstituted hydrazine
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02041D, PaperChenxia Yu, Shide Shen, Ligen Jiang, Jing Li, Yumiao Lu, Tuanjie Li, Changsheng Yao A formal [3+2] annulation of [small alpha]-bromoenal with monosubstituted hydrazine could give 1,5 or 2,5-difunctionalized 3-pyrazolidinone regiodivergently by tuning the structure of N-Heterocyclic Carbene (NHC) catalyst. The moderate to high yields,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2017 Category: Molecular Biology Authors: Chenxia Yu Source Type: research

Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA)
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02353G, PaperSean Yeldell, Brittani Ruble, Ivan Dmochowski Single cell transcriptomics provides a powerful discovery tool for identifying new cell types and functions as well as a means to probe molecular features of the etiology and treatment of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 13, 2017 Category: Molecular Biology Authors: Sean Yeldell Source Type: research

Evidence of single electron transfer from the enolate anion of an N,N[prime or minute]-dialkyldiketopiperazine additive in BHAS coupling reactions
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02209C, PaperKatie J. Emery, Tell Tuttle, John A. Murphy A designedN,N[prime or minute]-dialkyldiketopiperazine (DKP) provides evidence for the role of DKP additives as initiators that act by electron transfer in base-induced homolytic aromatic substitution reactions, involving coupling of haloarenes to arenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Katie J. Emery Source Type: research

Construction of Tetrahydropyranoquinoline Derivatives via an Asymmetric Organocatalytic aza-Michael-IED/HAD Cascade Reaction
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02231J, PaperLu Dai, Yuxuan Hou, Lvye Zhang, Zhangtao Chen, Xiaofei Zeng, Guofu Zhong Chiral functionalized tetrahydroquinolines and pyranoquinolines with multiple stereogenic centres have emerged as attractive structures for derivatizing bioactive complex molecules. Herein, we developed a novel, facile organocatalytic asymmetric aza-Michael-IED/HAD cascade reaction... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Lu Dai Source Type: research

Visible-light-mediated direct difluoromethylation of alkynoates: Synthesis of 3-difluoromethylated coumarins
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02366A, CommunicationMei Zhu, Weijun Fu, Zhiqiang Wang, Chen Xu, Baoming Ji A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed. The well-designed photoredox system induces a single-step, regioselective installation of a CF2H onto alkynes. Difluoromethyl sulfone was used as an easy... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Mei Zhu Source Type: research

Arginine Modification of Lycosin-I to Improve Inhibitory Activity Against Cancer Cells.
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02233F, PaperPeng Zhang, Jing Ma, Yujie Yan, Bo Chen, Bobo Liu, Cui Jian, Baode Zhu, Song ping Liang, Youlin Zeng, Zhonghua Liu Lycosin-I is a linear amphipathic [small alpha]-helical anticancer peptide (ACP) extracted from the spider Lycosa singoriensis, which can activate the mitochondrial death pathway to induce apoptosis in tumor cells and up-regulate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Peng Zhang Source Type: research

The synthesis of planar chiral pseudo-gem aminophosphine pre-ligands based on [2.2]paracyclophane
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02393F, PaperGareth J Rowlands, Krishanthi P Jayasundera, Tim G. W. Engels, David J. Lun, Maulik N. Mungalpara, Paul Plieger The synthesis of three planar chiral pseudo-gem disubstituted [2.2]paracyclophane-derived P,N-pre-ligands is reported along with preliminary results of their activity in the amination of aryl bromides and chlorides. The pseudo-gem aminophosphines... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Gareth J Rowlands Source Type: research

Accessing 2-substituted piperidine iminosugars by organometallic addition/intramolecular reductive amination: aldehyde vs nitrone route
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01848G, PaperStefania Mirabella, Giulia Fibbi, Camilla Matassini, Cristina Faggi, Andrea Goti, Francesca Cardona A DUAL SYNTHETIC STRATEGY TO AFFORD 2-SUBSTITUTED TRIHYDROXYPIPERIDINES WAS DISCLOSED. THE PROCEDURE INVOLVED GRIGNARD ADDITION EITHER TO A CARBOHYDRATE-DERIVED ALDEHYDE OR TO A NITRONE DERIVED THEREOF, AND TOOK ADVANTAGE OF... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Stefania Mirabella Source Type: research

Exploring the origins of selectivity in soluble Epoxide Hydrolase from Bacillus megaterium
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01847A, PaperEila Serrano-Hervas, Marc Garcia-Borras, Silvia Osuna Epoxide hydrolases (EHs) enzymes catalyze the hydration of racemic epoxides to yield their corresponding vicinal diols. These enzymes present different enantio- and regioselectivity depending upon either the substrate structure or... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 12, 2017 Category: Molecular Biology Authors: Eila Serrano-Hervas Source Type: research

Mechanistic Investigation on N [rightward arrow] C[small alpha] [rightward arrow] O Relay via Non-Brook Rearrangement: Reaction Conditions Promote Synthesis of Furo[3,2-c]pyridinones
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02081C, PaperLihan Zhu, Haiyan Yuan, Jingping Zhang A comprehensive density functional theory investigation was employed to disclose the effect of reaction conditions on the mechanism and effective anion relay sequence of a NaH promoted non-Brook rearrangement of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 11, 2017 Category: Molecular Biology Authors: Lihan Zhu Source Type: research

Silver-Catalyzed Decarboxylative Acylation of Quinoxalin-2(1H)-ones with [small alpha]-Oxo-carboxylic Acids
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02187A, PaperXiaobao Zeng, Chulong Liu, Xingyong Wang, Jianlan Zhang, Xinyan Wang, Yuefei Hu A novel silver-catalyzed decarboxylative acylation of [small alpha]-oxo-carboxylic acids was developed, by which various 3-acyl quinoxalin-2(1H)-ones were synthesized by direct C-H bond acylation of quinoxalin-2(1H)-ones. In this method, [small alpha]-oxo-carboxylic acids served... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2017 Category: Molecular Biology Authors: Xiaobao Zeng Source Type: research

A diversity oriented synthesis of natural product inspired molecular libraries
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02230A, PaperSubhabrata Sen, Jyoti Chauhan, Tania Luthra, Rambabu Gundla, Antonio Ferraro, Ulrike Holzgrabe Natural products are the origin for innumerable pharmaceutical drug candidates and also forms an important aspect of herbal remedies. They are source of various bioactive compounds. Herein we have leveraged... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2017 Category: Molecular Biology Authors: Subhabrata Sen Source Type: research

Ionic-Surfactant-Coated Subtilisin: Activity, Enantioselectivity, and Application to Dynamic Kinetic Resolution of Secondary Alcohols
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02181J, PaperKyungwoo Kim, Eungyung Lee, Cheolwoo Kim, Jaiwook Park, Mahn- Joo Kim In this work, we explored the utility of ionic-surfactant-coated Bacillus licheniformis subtilisin (ISCBLS) as the catalyst for the dynamic kinetic resolution of secondary alcohols. ISCBLS was prepared by freeze-drying Bacillus... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2017 Category: Molecular Biology Authors: Kyungwoo Kim Source Type: research

Decoding glycan protein interactions by a new class of asymmetric N-glycans
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02303K, PaperZhigang Wu, Yunpeng Liu, Lei Li, Xiu-Feng Wan, He Zhu, Yuxi Guo, Mohui Wei, Wanyi Guan, Peng George Wang N-glycans are normally involved in crucial physiological and disease processes by interactions with glycan binding proteins. So far structurally defined N-glycans are good candidates for glycan binding study. Herein, a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2017 Category: Molecular Biology Authors: Zhigang Wu Source Type: research

N-Acylsuccinimides: Twist-Controlled, Acyl-Transfer Reagents in Suzuki-Miyaura Cross-Coupling by N-C Amide Bond Activation
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02269G, CommunicationYuki Osumi, Chengwei Liu, Michal Szostak The palladium-catalyzed Suzuki-Miyaura cross-coupling of N-acylsuccinimides as versatile acyl-transfer reagents via selective amide N-C bond cleavage is reported. The method is user-friendly since it employs commercially-available, air-stable reagents and catalysts.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2017 Category: Molecular Biology Authors: Yuki Osumi Source Type: research

Synthesis of carbazole-based BODIPY dimer showing red fluorescence in the solid state
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02419C, CommunicationChihiro Maeda, Takumi Todaka, Tomomi Ueda, Tadashi Ema Carbazole-based BODIPY dimers 2a-g were synthesized via the direct arylation. They showed red-shifted solid-state fluorescence spectra as compared with the corresponding monomer. In addition, unsymmetrical dimers 2d, 2f, and 2g... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 10, 2017 Category: Molecular Biology Authors: Chihiro Maeda Source Type: research

Enantioselective organocatalytic Michael additions of N,N[prime or minute]-dialkylbarbituric acids to enones
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02116J, PaperYing Liu, Yongna Zhang, Hui-Xin Duan, Dong-Yan Wanyan, You-Qing Wang N,N[prime or minute]-Dialkylbarbituric acids as cyclic malonamide donors were successfully used in the organocatalytic asymmetric Michael additions with enones, affording the corresponding 5-substituted barbituric acid derivatives with 91-99% ee. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Ying Liu Source Type: research

Asymmetric synthesis of dihydrocoumarins via the organocatalytic hetero-Diels-Alder reaction of ortho-quinone methides
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02325A, PaperLili Zhang, Yang Liu, Kun Liu, Zhantao Liu, Ningning He, Wenjun Li Asymmetric synthesis of the dihydrocoumarin skeletonvia the organocatalytic [4 + 2] cycloaddition reaction ofortho-quinone methides with azlactones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Lili Zhang Source Type: research

Visible-light induced di- and trifluoromethylation of N-benzamides with fluorinated sulfones for the synthesis of CF2H/CF3-containing isoquinolinediones
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02226C, PaperGuanglong Zou, Xuelin Wang A photocatalytic radical di- or trifluoromethylation/cyclization of methacryloyl benzamides with fluorinated sulfones provided an efficient route to CF2H/CF3-containing isoquinoline-1,3(2H,4H)-diones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Guanglong Zou Source Type: research

I2/CHP mediated [1 + 1 + 1 + 1] cyclization of aromatic isocyanides with amines to construct 1,3-diazetidine-2,4-diimine derivatives
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02255G, PaperHai-Feng Liu, Tong-Hao Zhu, Pei Xu, Shun-Yi Wang, Shun-Jun Ji An I2/CHP (cumene hydroperoxide) mediated [1 + 1 + 1 + 1] cyclization of aromatic isocyanides with readily accessible aminesvia the formation of 4 new C-N bonds has been developed to construct unsymmetric 1,3-diazetidine-2,4-diimine derivatives under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Hai-Feng Liu Source Type: research

Efficient liposome fusion mediated by lipid-nucleic acid conjugates
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01939D, PaperOliver Ries, Philipp Max Gerhard Loffler, Alexander Rabe, Jegatha Jeyakumaran Malavan, Stefan Vogel The fusion of biomembranes with release of encapsulated content in a controlled way is crucial for cell signaling, endo- and exocytosis and intracellular trafficking. Programmable fusion of liposomes and an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Oliver Ries Source Type: research

Pd-catalysed Suzuki coupling of [small alpha]-bromo ethenylphosphonates with organotrifluoroborates: a general protocol for the synthesis of terminal [small alpha]-substituted vinylphosphonates
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02267K, PaperLi Zhang, Yewen Fang, Xiaoping Jin, Housan Xu, Ruifeng Li, Hao Wu, Bin Chen, Yiming Zhu, Yi Yang, Zongming Tian A general and robust protocol for the synthesis of terminal [small alpha]-substituted vinylphosphonates via Suzuki coupling of [small alpha]-bromovinylphosphonates with organotrifluoroborates has been successfully developed. This method features broad substrate scope, great... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Li Zhang Source Type: research

A ROS-Responsive Polymeric Micelle with [small pi]-Conjugated Thioketal Moiety for Enhanced Drug Loading and Efficient Drug Delivery
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01975K, PaperChangzhen Sun, Yan Liang, Na Hao, Long Xu, Furong Cheng, Ting Su, Jun Cao, Yuji Pu, Wenxia Gao, Bin He As the implications of reactive oxygen species (ROS) are elucidated in many diseases, ROS-responsive nanoparticles are attracting great interest of researchers. In this work, a ROS sensitive thioketal (TK) moiety... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Changzhen Sun Source Type: research

Decoration of trastuzumab with short oligonucleotides: synthesis and detailed characterization
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02216F, PaperAna Margarida Carvalho, Alex Manicardi, Cynthia Veliz Montes, Smita B Gunnoo, Rudolf J. Schneider, Annemieke Madder Trastuzumab (Herceptin[registered sign]) is an FDA-approved therapeutic antibody currently employed in the treatment of metastatic stages of breast cancer. Herein, we propose a simple, fast and cost-effective methodology to conjugate trastuzumab... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Ana Margarida Carvalho Source Type: research

Straightforward Synthesis of Man9, the relevant epitope of the High-Mannose Oligosaccharide
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02286G, CommunicationJavier Ramos-Soriano, M. Carmen de la Fuente, Noelia de la Cruz, Rute C. Figueiredo, Javier Rojo, Jose Juan Reina The high mannose structure (or its corresponding Man9 epitope) is the more abundant structure presented in pathogen envelope glycoproteins. These glycans play a key role in the pathogenesis of several... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Javier Ramos-Soriano Source Type: research

Selective recognition of quaternary ammonium ions and zwitterions by a biomimetic bis-calix[6]arene-based receptor
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02031G, PaperSteven Moerkerke, Volodymyr Malytskyi, Lionel Marcelis, Johan Wouters, Ivan Jabin Artificial receptors able to recognize efficiently chemical species bearing a quaternary ammonium group have potential applications in the fields of biological and environmental analysis. A possible biomimetic strategy for the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 9, 2017 Category: Molecular Biology Authors: Steven Moerkerke Source Type: research

Sugar hydrazide imides: a new family of glycosidase inhibitors
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01673E, CommunicationEmil Lindback, Oscar Lopez, Adne Tobiesen, Jose G Fernandez-Bolanos, Magne Olav Sydnes The preparation of a novel type of iminosugars including a hydrazide imide moiety is described. The sugar hydrazide imides (3S,4S,5R,6R)-1-amino-3,4,5-trihydroxy-6-(hydroxymethyl)-2-iminopiperidine acetate and (3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-1-(methylamino)-2-iminopiperidine acetate presented behave as inhibitors of [small alpha]/[small beta]-glucosidases... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Or...
Source: RSC - Organic and Biomolecular Chemistry - October 6, 2017 Category: Molecular Biology Authors: Emil Lindback Source Type: research

Phosphoramidate hydrolysis catalyzed by human histidine triad nucleotide binding protein 1 (hHint1): a cluster-model DFT computational study
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02098H, PaperGuangchao Liang, Charles Edwin Webster The histidine triad of hHint1 serves as a proton shuttle in the DFT proposed mechanism of the hydrolysis of phosphoramidate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 6, 2017 Category: Molecular Biology Authors: Guangchao Liang Source Type: research

Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02297B, PaperElizabeth W. Kelley, Skylar G. Norman, Jonathan R. Scheerer Synthesis of barettin, a selective serotonin receptor inhibitor and potent antibiofouling natural product. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 5, 2017 Category: Molecular Biology Authors: Elizabeth W. Kelley Source Type: research

Evidence of single electron transfer from the enolate anion of an N,N'-dialkyldiketopiperazine additive in BHAS coupling reactions
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02209C, PaperKatie J. Emery, Tell Tuttle, John Murphy A designed N,N'-dialkyldiketopiperazine (DKP) provides evidence for the role of DKP additives as initiators that act by electron transfer in base-induced homolytic aromatic substitution reactions, involving coupling of haloarenes to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 5, 2017 Category: Molecular Biology Authors: Katie J. Emery Source Type: research

Local conformational changes in the 8-17 deoxyribozyme core induced by activating and inactivating divalent metal ions
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02001E, PaperAlessio Peracchi, Maria Bonaccio, Alfredo Credali The 8-17 deoxyribozyme (DNAzyme) is a catalytic DNA molecule capable of cleaving specific RNA substrates. The deoxyribozyme is activated by a wide variety of divalent metal ions, from Mg2+ to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 5, 2017 Category: Molecular Biology Authors: Alessio Peracchi Source Type: research

Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02319G, CommunicationYu-lun Qian, Peng-Ju Xia, Jun Li, Qinglan Zhao, Jun-An Xiao, Haoyue Xiang, Hua Yang Diversity-driven three-component 1,3-dipolar cycloaddition of isatin, amino acid and isatin-derived ketimine was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers. This protocol features additive-free, minimal solvent usage... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 5, 2017 Category: Molecular Biology Authors: Yu-lun Qian Source Type: research

Pd-catalyzed desulfitative arylation for the synthesis of 2,5-diarylated oxazole-4-carboxylates using dioxygen as the terminal oxidant
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01912B, CommunicationXiaodong Tang, Kai Yang, Liying Zeng, Qiang Liu, Huoji Chen A novel palladium-catalyzed approach for constructing 2,5-diarylated oxazole-4-carboxylates using sodium arylsulfinates as the aryl source has been demonstrated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 4, 2017 Category: Molecular Biology Authors: Xiaodong Tang Source Type: research

Enzymatic Monoesterification of Symmetric Diols: Restriction of Molecular Conformations Influences Selectivity
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01951C, PaperSoni P Hemant, Sanjiv O Tomer We have experimentally demonstrated that by 'locking' the molecular conformation through the introduction of a double or triple bond in the center of symmetric diols, enzymatic monoesterification can be achieved... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 4, 2017 Category: Molecular Biology Authors: Soni P Hemant Source Type: research

Ru-catalysed synthesis of fused heterocycle-pyridinones and -pyrones
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01497J, PaperEsteban Pablo Urriolabeitia, Sara Ruiz, Clara Carrera, Pedro Villuendas The synthesis of fused heterocycle-pyridinones has been achieved by oxidative coupling of N-unprotected primary heterocycle-amides with internal alkynes. The reaction, which is catalysed by Ru(II) and assisted by Cu(II), takes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 4, 2017 Category: Molecular Biology Authors: Esteban Pablo Urriolabeitia Source Type: research

Synthesis and biological evaluation of novel teixobactin analogues
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02169K, PaperChristian Schumacher, Paul Harris, Xiaobo Ding, Bernhard Krause, Tom Wright, Greg Cook, Daniel Furkert, Margaret A Brimble The cyclic depsipeptide, teixobactin, possesses promising activity against a range of antimicrobial-resistant (AMR) pathogenic bacteria, including Staphylococcus aureus and Mycobacterium tuberculosis. Teixobactin contains a number of non-canonical residues, including the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 4, 2017 Category: Molecular Biology Authors: Christian Schumacher Source Type: research

Bronsted-base-catalyzed Remote Cascade Reactivity of 2,4-Dienones - Asymmetric Synthesis of Tetrahydrothiophenes
This study demonstrates that the remote cascade functionalization of 2,4-dienones can be realized employing Bronsted base catalysis. The developed cascade involving 1,6-addition followed by the intramolecular aldol reaction provides a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - October 4, 2017 Category: Molecular Biology Authors: Artur Przydacz Source Type: research