Uncatalyzed diastereoselective synthesis of alkyliminofurochromone-derived benzylmalononitriles via a three-component cascade reaction: Competition between Diels-Alder cycloaddition and Michael addition
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02540B, PaperMohammad Bagher Teimouri, Zahra Mokhtare, Hamid Reza Khavasi Diastereoselective Friedel-Crafts C1-alkylation reactions of 3-(alkylamino)-9H-furo[3,4-b]chromen-9-one intermediate, produced from the [1+4] cycloaddition/tautomerization reaction between 3-formylchromones and alkyl isocyanide in dry CH2Cl2, with arylidene malononitrile were developed to afford a wide... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 5, 2021 Category: Molecular Biology Authors: Mohammad Bagher Teimouri Source Type: research

Synthesis of dibenzocyclohepta[1,2-a]naphthalene derivatives from phenylacetaldehyde and alkynyl benzyl alcohols via sequential electrophilic addition and double Friedel –Crafts reactions
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB00057H, CommunicationArchana K. Sahu, Ramanjaneyulu Unnava, Bipin K. Behera, Anil K. Saikia A simple methodology for the regioselective synthesis of substituted dibenzocyclohepta[1,2-a]naphthalenes from phenylacetaldehydes andortho-alkynyl benzyl alcohols in the presence of a Lewis acid has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 4, 2021 Category: Molecular Biology Authors: Archana K. Sahu Source Type: research

C4-aldehyde of guaiazulene: synthesis and derivatisation
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Georgia E. Williams, Gabriele Kociok-K öhn, Tony D. James, Simon E. Lewis The C4 methyl group of guaiazulene can be transformed into the corresponding aldehyde in a chemo- and regioselective manner. This aldehyde is a versatile building block from which C4-alkenylated guaiazulenes that exhibit halochromism may be accessed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 4, 2021 Category: Molecular Biology Authors: Georgia E. Williams Source Type: research

An organophosphorus-mediated cross-Rauhut –Currier/Wittig domino reaction for the efficient synthesis of trisubstituted cyclopentenes
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB00150G, PaperYa-Qiong Li, Guo-Dong Xu, Zhi-Zhen Huang An organophosphorus-mediated cross-Rauhut –Currier/Wittig domino reaction of vinyl ketones with chalcones has been developed for the efficient synthesis of trisubstituted cyclopentenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 4, 2021 Category: Molecular Biology Authors: Ya-Qiong Li Source Type: research

Novel and efficient synthesis of fused spiro piperidone-cyclopropanes from cascade reaction of 1-acylcyclopropanecarboxamides and polarized olefin
We report here that a series of O-bridged ring fused spiro piperidone-cyclopropane derivatives 3 can be constructed in a single step by the one-pot reaction of 1-acylcyclopropanecarboxamides 1 with polarized... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 4, 2021 Category: Molecular Biology Authors: Xiao Dan Han Source Type: research

Metal-free Access to 3-Allyl-2-alkoxychromanones via Phosphine-Catalyzed Alkoxy Allylation of Chromones with MBH Carbonates and Alcohols
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00215E, CommunicationLing Meng, Xiaoyong Chang, Zhenyang Lin, Jun Wang Metal-free alkoxy allylation of 3-cyanochromones with MBH carbonates and alchohols catalyzed by triphenylphosphine has been developed, producing a series of 3-allyl-2-alkoxychromanones in moderate to high yields (61-98%) with excellent diastereoselectivities... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 3, 2021 Category: Molecular Biology Authors: Ling Meng Source Type: research

The Effect of Carbonyl on the Isomerization of Galanthan Ring System and Total Synthesis of ( ±)-β-lycorane via a Double Michael Addition Approach
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02398A, PaperLeilei Liang, Ji Li, baochun shen, Yili Zhang, Jianping Liu, Jingbo Chen, Dandan Liu Lycorine-type alkaloids are privileged structures in the drug development due to its attractive biological activities. In this paper, the carbonyl on the C ring was proved to have played a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 3, 2021 Category: Molecular Biology Authors: Leilei Liang Source Type: research

Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02380A, Review ArticleArtur Przydacz, Jan Bojanowski, Anna Albrecht, Łukasz Albrecht 1,3-Dipolar cycloaddition constitutes powerful means for the synthesis of five-membered heterocycles. Recently, the potential of this field of chemistry has been expanded by the employment of organocatalytic activation strategies. One... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 3, 2021 Category: Molecular Biology Authors: Artur Przydacz Source Type: research

The Copper-catalyzed Chemoselective Monoalkylation of Active Methylene Compounds with Alkylsilyl Peroxides
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00075F, CommunicationJiamin Lv, Weiping Xu, Hanbin Lu, Terumasa Kato, Yan Liu, Keiji Maruoka A novel method for a mild copper-catalyzed chemoselective monoalkylation of active methylene compounds with various alkylsilyl peroxides has been developed. The reaction has a broad substrate scope and our mechanistic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 3, 2021 Category: Molecular Biology Authors: Jiamin Lv Source Type: research

Construction of bridged polycycles through dearomatization strategies
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00096A, Review ArticleZiying Zhang, Hua-Bin Han, Lele Wang, Zhanwei Bu, Yan Xie, Qi-Lin Wang Bridged polycycles are privileged molecular skeletons with wide occurrence in bioactive natural products and pharmaceuticals. Therefore, they have been the pursing target molecules of numerous chemists. The rapid and convenient... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 3, 2021 Category: Molecular Biology Authors: Ziying Zhang Source Type: research

The thioamidation of gem-dibromoalkenes in an aqueous medium
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D0OB02319A, PaperJigarkumar K. Vankar, Ankush Gupta, Jaydeepbhai P. Jadav, Shankara H. Nanjegowda, Guddeangadi N. Gururaja The direct integration of sulphur and amine groups with 1,1-dibromoalkenes for thioamide synthesis has been achieved in an aqueous medium. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Jigarkumar K. Vankar Source Type: research

α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jacqueline Bitai, Matthew T. Westwood, Andrew D. Smith α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformations including Michael additions, domino reactions and cycloadditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Jacqueline Bitai Source Type: research

Pd-oxazolone complexes conjugated to an engineered enzyme: Improving fluorescence and catalytic properties
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00305D, PaperCarla Garcia-Sanz, Alicia Andreu, blanca de las rivas, Ana I. Jimenez, Alexandra Pop, Cristian Silvestru, Esteban Pablo Urriolabeitia, Jose M. Palomo Different Pd-complexes containing orthometallated push-pull oxazolones were inserted by supramolecular Pd-amino acid coordination on two genetically engineered modified variants of the thermoalkalophilic Geobacillus thermocatenolatus lipase (GTL). The Pd-lipase conjugation was... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Carla Garcia-Sanz Source Type: research

Amidino substituted 2-aminophenols: Biologically important building blocks for the amidino-functionalization of 2-substituted benzoxazoles
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00235J, PaperLucija Pti ček, Lucija Hok, Petra Grbčić, Filip Topić, Mario Cetina, Kari Rissanen, Sandra Kraljević Pavelić, Robert Vianello, Livio Racane Unlike their closely related and widely investigated amidino-substituted benzimidazoles and benzothiazoles with a range of demonstrated biological activities, the matching benzoxazole analogues still remain a largely understudied and not systematically... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Lucija Pti ček Source Type: research

A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Jannicke Irina Nesman, Ouyang Chen, Xin Luo, Ru-Rong Ji, Charles Nicholas Serhan, Trond Vidar Hansen The resolution of inflammation is a biosynthetically active process controlled by the interplay between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling pathways. These oxygenated polyunsaturated fatty acids belong to distinct... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Jannicke Irina Nesman Source Type: research

Multicomponent reactions as a potent tool for the synthesis of benzodiazepines
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02600J, Review ArticleHassan Farhid, Vida Khodkari, Mohammad Taghi Nazeri, Siamak Javanbakht, Ahmad Shaabani Benzodiazepines (BZDs), a diverse class of benzofused seven-memberedN-heterocycles, display essential pharmacological properties and play vital roles in some biochemical processes. They have majorly been prescribed as potential therapeutic agents,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Hassan Farhid Source Type: research

Regiocontrolled synthesis of 2,4,6-triarylpyridines from methyl ketones, electron-deficient acetylenes and ammonium acetate
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00193K, PaperDmitrii Shabalin, Marina Dvorko, Elena Schmidt, Boris Trofimov A novel one-pot two-step approach for the synthesis of 2,4,6-triarylpyridines via t-BuOK/DMSO-promoted C-vinylation of a variety of methyl ketones with electron-deficient acetylenes (alkynones) followed by a cyclization of the in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 2, 2021 Category: Molecular Biology Authors: Dmitrii Shabalin Source Type: research

Cyanoalkylation/alkynylation of allylic alcohol through intramolecular radical 1,2-alkynyl migration
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB00192B, CommunicationShengnan Jin, Fan Chen, Pengcheng Qian, Jiang Cheng A di-tert-butyl peroxide (DTBP)-promoted difunctionalization of α-aryl α-alkynyl allylic alcohols with alkyl nitriles was developed, affording a series of α-alkynyl γ-cyano functionalized ketones in moderate yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 1, 2021 Category: Molecular Biology Authors: Shengnan Jin Source Type: research

Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB00007A, PaperXuanjun Wu, Hunter McFall-Boegeman, Zahra Rashidijahanabad, Kunli Liu, Christian Pett, Jin Yu, Manuel Schorlemer, Sherif Ramadan, Sandra Behren, Ulrika Westerlind, Xuefei Huang A MUC1 glycopeptide bearing an unnatural β-glycosyl bond between the glycan and the peptide backbone was synthesized. The mimic can induce high levels of IgG antibodies cross-recognizing cancer cells expressing the native MUC1 glycoprotein. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal S...
Source: RSC - Organic and Biomolecular Chemistry - March 1, 2021 Category: Molecular Biology Authors: Xuanjun Wu Source Type: research

Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect.
We report herein a series of Ohmline ’s analogues featuring the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 1, 2021 Category: Molecular Biology Authors: Charlotte M Sevrain Source Type: research

Direct and Straightforward Transfer of C1 Functionalized Synthons to Phosphorous Electrophiles for Accessing gem-P-Containing Methanes
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00273B, CommunicationSaad Touqeer, Laura Ielo, Margherita Miele, Ernst Urban, Wolfgang Holzer, Vittorio Pace The direct transfer of different α-substituted methyllithium reagents to chlorinated phosphorous electrophiles of diverse oxidation state (phosphates, phosphine oxides and phosphines) is proposed as an effective strategy to synthesize geminal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 1, 2021 Category: Molecular Biology Authors: Saad Touqeer Source Type: research

α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jacqueline Bitai, Matthew Westwood, Andrew D Smith α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformation including Michael additions, domino reactions and cycloadditions. Many of these transformations are promoted by... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 1, 2021 Category: Molecular Biology Authors: Jacqueline Bitai Source Type: research

A versatile approach to the synthesis of glycans containing mannuronic acid residues
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00188D, PaperCatherine Alex, Satsawat Visansirikul, Alexei V Demchenko Reported herein is a new method for a highly effective synthesis of β-glycosides from mannuronic acid donors equipped with the 3-O-picoloyl group. The stereocontrol of glycosylations was achieved by means... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 27, 2021 Category: Molecular Biology Authors: Catherine Alex Source Type: research

Monofluorinated 5-membered rings via fluoromethylene transfer: synthesis of monofluorinated isoxazoline N-oxides
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00270H, PaperArturs Sperga, Armands Kazia, Janis Veliks The synthesis of five-membered rings using fluoromethylene transfer chemistry is an attractive method for building fluorinated products of high value. This work demonstrates for the first time that one-fluorine-one-carbon modification... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 27, 2021 Category: Molecular Biology Authors: Arturs Sperga Source Type: research

N-Alkenylation of Hydroxamic Acid Derivatives with Ethynyl Benziodoxolone to Synthesize cis-Enamides Through Vinyl Benziodoxolones
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00055A, PaperDaisuke Shimbo, Toshifumi Maruyama, Norihiro Tada, Akichika Itoh The stereoselective synthesis of cis- β-N-alkoxyamidevinyl benziodoxolones (cis-β-N-RO-amide-VBXs) from O-alkyl hydroxamic acids in the presence of an ethynyl benziodoxolone–acetonitrile complex (EBX–MeCN) is reported herein. The reaction was performed under mild conditions... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 27, 2021 Category: Molecular Biology Authors: Daisuke Shimbo Source Type: research

Aromatic Cope Rearrangements
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00094B, Review ArticleBreanna Tomiczek, Alexander Grenning Reviewed herein is the aromatic Cope rearrangement, a Cope rearrangement where one (or both) of the alkenes of the 1,5-diene are part of a greater aromatic system. While the Cope... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Breanna Tomiczek Source Type: research

Visible Light Promoted Photoredox C(sp3) –H Bond Functionalization of Tetrahydroisoquinolines in Flow
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02582H, CommunicationAna Filipovi ć, Zdravko Dzambaski, Dana Vasiljevic-Radovic, Bojan Bondžić A merger of organocatalysis and visible light photoredox catalysis performed in flow allowed access to a wide range of functionalized N-Aryl-substituted tetrahydoisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. Strecker... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Ana Filipovi ć Source Type: research

Peroxide- and Transition Metal-Free Electrochemical Synthesis of α,β-Epoxy Ketones
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02444A, PaperMengxun Zhang, Tie Chen, Shisong Fang, Weihua Wu, Xin Wang, Haiqiang Wu, Yongai Xiong, Jun Song, Chen-yang Li, Zhendan He, Chi-Sing Lee A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Mengxun Zhang Source Type: research

Electrohalogenation of Organic Compounds
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02459G, Review ArticleAntonio Luiz Braga, Guilherme Machado Martins, Marcos R. Scheide, Celso Rodrigo Nicoleti Herein, we present an overview of recent advances in the electrochemical halogenation of organic compounds. Halogen-containing compounds are essential building blocks for post-functionalization in academic research and in different industrial... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Antonio Luiz Braga Source Type: research

K2S2O8-Mediated regio- and stereo-selective thiocyanation of enamides with NH4SCN
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00156F, PaperQingyun Gu, Qiyang Wang, Wenjing Dai, Xin Wang, Yingguo Ban, Tianqing Liu, Yu Zhao, Yanan Zhang, Yong Ling, Xiaobao Zeng A direct and straightforward thiocyanation of enamides with NH4SCN under metal-free conditions has been accomplished. A variety of (E)- β-thiocyanoenamides are readily produced in a regio- and stereo-selective manner. The protocol... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Qingyun Gu Source Type: research

Ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ): tunable halogenation and quinone formation using NaX/Oxone
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Darren Conboy, Patrick Kielty, Joseph C Bear, Jeremy Karl Cockcroft, Pau Farras Costa, Patrick McArdle, Richard Singer, Dennis Smith, Fawaz Aldabbagh Ring-fused benzimidazolequinones are well-known anti-tumour agents, but dimeric ring-fused adducts are new. The alicyclic [1,2-a] ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ) intermediate allows late-stage functionalization of bis-p-benzimidazolequinones. DMBBQs are chlorinated and brominated at... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - O...
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Darren Conboy Source Type: research

Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jade Nguyen, Alina Tirla, Pablo Rivera-Fuentes The release of tributylphosphine in mitochondria induces morphological changes and upregulates specific genes from the integrated stress response, such as CHAC1. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 26, 2021 Category: Molecular Biology Authors: Jade Nguyen Source Type: research

NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D0OB02169E, Review ArticlePrasanjit Ghosh, Bhaskar Ganguly, Sajal Das An unique combination of MI-TBHP (M = Na, K, NH4) oxidation system has ameliorated the metal-free access to construct various chemical bonds and appeared as an impeccable synthetic manoeuvre for the construction of complex molecular frameworks. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Prasanjit Ghosh Source Type: research

In vitro characterization of 3-chloro-4-hydroxybenzoic acid building block formation in ambigol biosynthesis
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D0OB02372H, PaperI Dewa Made Kresna, Luis Linares-Otoya, Tobias Milzarek, Elke R. Duell, Mahsa Mir Mohseni, Ute Mettal, Gabriele M. K önig, Tobias A. M. Gulder, Till F. Schäberle The cyanobacterium  Fischerella ambigua is a natural producer of polychlorinated aromatic compounds, the ambigols A–E. Here insights into the biosynthesis of these natural products are revealed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organ...
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: I Dewa Made Kresna Source Type: research

Synthesis of dibenzo cyclohepta[1,2-a]naphthalene derivatives from phenylacetaldehyde and alkynyl benzyl alcohols via sequential electrophilic addition and double Friedel-Crafts reactions
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00057H, CommunicationAnil Saikia, Archana Kumari Sahu, Ramanjaneyulu Unnava, Bipin Kumar Behera A simple methodology has been developed for the synthesis of substituted 9H-dibenzo[3,4:6,7]-cyclohepta[1,2-a]naphthalenes from phenylacetaldehydes and ortho-alkynyl benzyl alcohols in presence of Lewis acid in moderate to good yields within a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Anil Saikia Source Type: research

Continuous Flow as an Enabling Technology: A Fast and Versatile Entry to Functionalized Glyoxal Derivatives
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00288K, CommunicationFabio Lima, Mark Meisenbach, Berthold Schenkel, Joerg Sedelmeier We herein report two complementary strategies employing organolithium chemistry for the synthesis of glyoxal derivatives. Micro-mixer technology allows for the generation of unstable organometallic intermediates and their instantaneous in-line quench... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Fabio Lima Source Type: research

Retraction: Convenient synthesis of pyrimidine 2 ′-deoxyribonucleoside monophosphates with important epigenetic marks at the 5-position
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Song Zheng, Ai Tran, Alyson M. Curry, Dawanna S. White, Yana Cen To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Song Zheng Source Type: research

Cholesteryl glucosides signal through the carbohydrate recognition domain of the macrophage inducible C-type lectin (mincle)
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D0OB02342F, CommunicationMattie S. M. Timmer, Thomas J. Teunissen, Kristel Kodar, Amy J. Foster, Sho Yamasaki, Bridget L. Stocker H. pylori derived cholesteryl glycosides signal through the Carbohydrate Recognition Domain (CRD) of the Macrophage inducible C-type lectin (Mincle). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Mattie S. M. Timmer Source Type: research

A powerful azomethine ylide route mediated by TiO2 photocatalysis for the preparation of polysubstituted imidazolidines
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D0OB02277B, CommunicationAnan Liu, Dongge Ma, Yuhang Qian, Jundan Li, Shan Zhai, Yi Wang, Chuncheng Chen TiO2 photocatalysis strategy can mediate 1,3-dipolar cycloaddition between unstablized azomethine ylide and imine to synthesize N-heterocylic imidazolidines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Anan Liu Source Type: research

Photoresponsive host –guest chemistry and relaxation time of fluorinated cyclodextrin and arylazopyrazole-functionalized DOTA metal complexes
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D0OB02482A, CommunicationJulian Simke, Till B öckermann, Klaus Bergander, Sina Klabunde, Michael Ryan Hansen, Bart Jan Ravoo The photomodulation of a host –guest complex provides a new concept for a responsive19F MRI contrast agent in aqueous solution. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Julian Simke Source Type: research

Synthesis of methanesulfone-containing tetrasubstituted carbon stereocenters
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB00071C, PaperWei Zhou, You-Ping Tian, Hao-Jie Zhou, Hui-Juan Wang, Yan Ren, Xiong-Li Liu Synthesis of sulfone-containing tetrasubstituted carbon stereocenters. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Wei Zhou Source Type: research

Investigating Eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00253H, CommunicationNeil Taylor, Joanna Francelle McGouran Eoisn Y was assessed for its ability to induce a thiol-ene dependent protein-protein reaction in a metal-free, oxygen tolerant, visible light mediated system. Protein-protein coupling efficiency under these mild conditions... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Neil Taylor Source Type: research

Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00007A, PaperXuanjun Wu, Hunter McFall-Boegeman, Zahra Rashidijahanabad, Kunli Liu, Christian Pett, Jin Yu, Manuel Schorlemer, Sherif Ramadan, Sandra Behren, Ulrika Westerlind, Xuefei Huang MUC1 glycopeptides are attractive antigens for anti-cancer vaccine development. One potential drawback in using the native MUC1 glycopeptide for vaccine design is the instability of the O-glycosyl linkage between the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Xuanjun Wu Source Type: research

Chemistry and Biology of Spiroacetals from Myxobacteria
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00026H, Review ArticleMark A Rizzacasa, Michael Ricca This review details the isolation, biosynthesis, biological activity and synthesisof spiroacetals from the myxobacterium Sorangium cellulosum. The strategiesutilised to access the challenging structures and stereochemistry of these natural products are... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Mark A Rizzacasa Source Type: research

A Novel Copper-Assisted Synthesis Method for Dihydropyrano[2.3-b]Indole-4-ones by Domino Cascade Reaction
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00078K, PaperYang Luo, Xue Zhong, Jiangkun Huang, Ling He A novel copper-catalyzed cascade interolecular and intramolecular oxidation/cyclization domino one-pot reaction process for the regioselective synthesis of dihydropyrano[2.3-b]indol-4(9H)-ones has been successfully developed. In this methodology, it is proposed for the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 25, 2021 Category: Molecular Biology Authors: Yang Luo Source Type: research

Synthesis of novel pyrazolo[3,4-b]quinolinebisphosphonic acids and an unexpected intramolecular cyclization and phosphonylation reaction
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00025J, PaperFatima C. Teixeira, Carla Lucas, M. Jo ão M. Curto, Vania Andre, Maria Teresa Teresa Duarte, António P. S. Teixeira Novel pyrazolo[3,4-b]quinoline -ketophosphonic and hydroxymethylenebisphosphonic acid compounds were synthesized using different methodologies, starting from 2-chloro-3-formylquinoline 1. New phosphonic acid compounds were obtained as N-1 derivatives with a side chain with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 24, 2021 Category: Molecular Biology Authors: Fatima C. Teixeira Source Type: research

Zn(OTf)2-Catalyzed Hydroamination of Ynamides with Aromatic Amines
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02603D, PaperZhuo Chen, Xiao-Di Nie, Jianting Sun, Aimei Yang, Bangguo Wei The Zn(OTf)2-catalyzed hydroamination of ynamides 2a-2l with aromatic amines 1a-1r was developed. This protocol features broad substrate scope of aromatic amines, good functional group tolerance for ynamides, and excellent regioselectivities.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 24, 2021 Category: Molecular Biology Authors: Zhuo Chen Source Type: research

Ruthenium(II)-Catalyzed Decarbonylative and Decarboxylative Coupling of Isatoic Anhydrides with Salicylaldehydes: Access to Aryl 2-Aminobenzoates
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00027F, PaperBidisha R. Bora, Rashmi Prakash, Sabera Sultana, Sanjib Gogoi A ruthenium(II)-catalyzed coupling reaction of isatoic anhydrides and salicylaldehydes has been developed for the synthesis of 2-aminobenzoates. This reaction proceeds through metal-catalyzed decarbonylation and decarboxylation to afford good yields of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 24, 2021 Category: Molecular Biology Authors: Bidisha R. Bora Source Type: research

Modern approaches towards one-carbon homologation functionalization of aldehydes
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00135C, Review ArticleSharol Sebastian, Monika Yadav, Anil Kumar Khatana, Eqvinshi Yadav, Manoj K Gupta One-carbon homologation functionalization in organic synthesis is quite challenging and difficult task in terms of atom economy, ease of reaction, selectivity and number of steps involved. Due to the reactivity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 24, 2021 Category: Molecular Biology Authors: Sharol Sebastian Source Type: research

Chemoselective Electrochemical Reduction of Nitroarenes with Gaseous Ammonia
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB00077B, PaperLiu Chang, Jin Li, Na Wu, Xu Cheng Valuable aromatic nitrogen compounds can be synthesized by reduction of nitroarenes. Herein, we report electrochemical reduc-tion of nitroarenes by a protocol that uses inert graphite felt as electrodes and ammonia... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 23, 2021 Category: Molecular Biology Authors: Liu Chang Source Type: research