Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Marianna Loizzi, David J. Miller, Rudolf K. Allemann Aza-analogues of carbocations inhibit δ-cadinene synthase: 1,6-cyclisation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2019 Category: Molecular Biology Authors: Marianna Loizzi Source Type: research

Correction: Enantioselective copper catalysed intramolecular C –H insertion reactions of α-diazo-β-keto sulfones, α-diazo-β-keto phosphine oxides and 2-diazo-1,3-diketones; the influence of the carbene substituent
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Amy E. Shiely, Catherine N. Slattery, Alan Ford, Kevin S. Eccles, Simon E. Lawrence, Anita R. Maguire To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2019 Category: Molecular Biology Authors: Amy E. Shiely Source Type: research

Tandem synthesis of 4-aminoxanthones is controlled by a water-assisted tautomerization: A general straightforward reaction
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02527D, PaperAna Bornadiego, Jes ús Díaz Álvarez, Carlos F. Marcos Aminoxanthones constitute a group of therapeutically promising compounds that so far have been synthetically challenging. Here, we report the synthesis of both aminodihydroxanthones and fully aromatized aminoxanthones by an easy... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2019 Category: Molecular Biology Authors: Ana Bornadiego Source Type: research

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03150A, PaperPhillip T Lowe, Sergio dall'Angelo Dall'Angelo, Ian Fleming, Monica Piras, Matteo Zanda, David O'Hagan Enzymatic radiosynthesis of a fluorinated Glu-Ureido-Lys-based inhibitor targeting the prostate-specific membrane antigen (PSMA) Phillip T. Lowe,a Sergio Dall ’Angelo,b Ian N. Fleming,c Monica Piras,b Matteo Zandab,d* and David O'Hagana* The prostate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2019 Category: Molecular Biology Authors: Phillip T Lowe Source Type: research

Enantiomeric NMR discrimination of carboxylic acids using Actinomycin D as a chiral solvating agent
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03012J, PaperLiwen Bai, Pian Chen, Jiangxia Xiang, Jiarui Sun, Xinxiang Lei Actinomycin D (Act-D) is a biologically important polypeptide antibiotic clinically used to treat several malignant tumors. Herein, we extended its hitherto-unexplored as an applicable chiral solvating agent (CSA) for the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2019 Category: Molecular Biology Authors: Liwen Bai Source Type: research

Copper-mediated oxidative [3+2]-annulation of nitroalkenes and pyridinium ylides: a general access to functionalized indolizines. Efficient synthesis of 1-fluoroindolizines
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03126F, PaperVladimir Motornov, Andrey Tabolin, Yulia V. Nelyubina, Valentine Nenajdenko, Sema Ioffe A general method for the synthesis of substituted indolizines by copper (II) acetate-promoted oxidative [3+2]-annulation of α-fluoronitroalkenes with in situ generated pyridinium ylides was developed. Application of the copper (II)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Vladimir Motornov Source Type: research

An endoplasmic reticulum-targetable fluorescent probe for highly selective detection of hydrogen sulfide
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02998A, PaperHui Zhang, Jiali Chen, Haiqing Xiong, Yun Zhang, Wenqiang Chen, Jiarong Sheng, Xiangzhi Song Hydrogen sulfide (H2S), a critical endogenous signaling molecule, is widely involved in many physiological processes. Endoplasmic reticulum, an important organelle with sac-like structure, plays crucial roles in maintaining the normal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Hui Zhang Source Type: research

I2/DMSO-Mediated Multicomponent Reaction of o Hydroxyaryl Methyl Ketones, Rongalite, and Dimethyl Sulfoxide: Access to C3-Sulfenylated Chromones
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02994F, PaperMiao Wang, Bo-Cheng Tang, Jin-Tian Ma, Zi-Xuan Wang, Jia-Chen Xiang, Yan-Dong WU, Jun-Gang Wang, An-Xin Wu An e fficient I2−DMSO reagent system-mediated multicomponent reaction strategy for the synthesis of C3-sulfenylated chromones from o‑hydroxyaryl methyl ketones, rongalite, and dimethyl sulfoxide has been developed. Notably, the double C–S bond... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Miao Wang Source Type: research

Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of difluorinated C17,C27-fragments
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03152E, PaperEric Jim Thomas, Paul R Mears, Steven Hoekman, Claire Rye, Fiona Bailey, Dominic Byrne, Patrick A Eyers Bryostatins with modified C17-C27 fragments have not been widely studied. The synthesis of 20,20-difluorinated analogues was therefore investigated. Such substitution would inhibit dehydration involving the C19-hydroxyl group and stabilise the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Eric Jim Thomas Source Type: research

Synthesis of diphenylamine macrocycles and their anti-inflammatory effect
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03121E, PaperAlejandra Ch ávez-Riveros, Eduardo Hernández-Vázquez, Antonio Nieto-Camacho, María Teresa Obdulia Ramírez-Apan, Luis D. Miranda A collection of fourteen diphenylamine macrocyclic derivatives containing a peptide chain with different substituents was synthesized using a protocol of two Ugi four component reactions (Ugi-4CR) and a Buchwald-Hartwig macrocyclization.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Alejandra Ch ávez-Riveros Source Type: research

Imidazole Carbamate Probes for Affinity Guided Azide-Transfer to Metal-Binding Proteins
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03017K, CommunicationMichael Rosholm Mortensen, Nanna Louise Nielsen, Johan Palmfeldt, Kurt Vesterager Gothelf Probes for affinity guided conjugation have shown great promise for the preparation of high-quality protein conjugates. However, such probes are often limited in their protein scope. Here, we demonstrate the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Michael Rosholm Mortensen Source Type: research

[RhIII(Cp*)]-catalyzed arylfluorination of α-diazoketoesters for facile synthesis of α-aryl-α-fluoroketoesters
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02801J, PaperFo-Ning Ng, Chun-Ming Chan, Jianbin Li, Mingzi Sun, Yin-Suo Lu, Zhongyuan Zhou, Bolong Huang, Wing-Yiu Yu The Cp*Rh(III)-catalyzed cascade arylfluorination reactions of α-diazoketoesters with arylboronic acids andN-fluorobenzenesulfonimide for one-pot C(sp3) –C(aryl) and C(sp3) –F bond formation was achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Fo-Ning Ng Source Type: research

Silver-mediated oxidative C –C bond sulfonylation/arylation of methylenecyclopropanes with sodium sulfinates: facile access to 3-sulfonyl-1,2-dihydronaphthalenes
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03045F, CommunicationYu Liu, Qiao-Lin Wang, Zan Chen, Quan Zhou, Cong-Shan Zhou, Bi-Quan Xiong, Pan-Liang Zhang, Chang-An Yang, Ke-Wen Tang The novel AgNO3-mediated sulfonylation/arylation of a C –C σ-bond in MCPs with sodium sulfinates to synthesize 3-sulfonylated 1,2-dihydronaphthalenes is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Yu Liu Source Type: research

The versatile use of solubilizing trityl tags for difficult peptide/protein synthesis
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03098G, PaperShugo Tsuda, Shun Masuda, Taku Yoshiya Our solubilizing trityl tags designed for difficult peptide/protein synthesis proved applicable to metal-free radical-triggered desulfurization and an Ag-mediated thioester method. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Shugo Tsuda Source Type: research

Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S –H/N–H
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03211D, CommunicationShanyu Tang, Yan Liu, Longjia Li, Xuanhe Ren, Jiao Li, Guanyu Yang, Heng Li, Bingxin Yuan The synthesis of sulfenamidesvia the oxidant- and metal-free electrochemical dehydrogenative coupling reaction of thiols and amines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Shanyu Tang Source Type: research

Recent advances in transition metal-catalyzed C(sp2) –H nitration
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02750A, Review ArticleLi-Rui Song, Zhoulong Fan, Ao Zhang This review updates advances of direct C(sp2) –H nitration for the synthesis of nitroaromatic compounds and the mechanisms during the past decade. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2019 Category: Molecular Biology Authors: Li-Rui Song Source Type: research

Quadruply N-methylated octaphyrin: a helical macrocycle exhibiting chiroptical properties and dynamic conformation changes correlated with helical and inner N-methyl orientations
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03161D, PaperWakana Naito, Kazuki Urakawa, Ryuma Sato, Yasuteru Shigeta, Nobuhiro Yasuda, Hiromitsu Maeda [38]Octaphyrin(1.1.1.1.1.1.1.1) bearing four methyl moieties at the inner nitrogen sites has been synthesized and exhibited chiroptical properties and dynamic conversions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2019 Category: Molecular Biology Authors: Wakana Naito Source Type: research

Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02996B, PaperTaylor A. Lundy, Shogo Mori, Sylvie Garneau-Tsodikova The adenylation (A) domains found in nonribosomal peptide synthetases (NRPSs) exhibit tremendous plasticity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2019 Category: Molecular Biology Authors: Taylor A. Lundy Source Type: research

Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C –H insertion of cubane
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02959H, CommunicationSevan D. Houston, Benjamin A. Chalmers, G. Paul Savage, Craig M. Williams An enantioselective synthesis of the non-proteinogenic amino acid (R)-2-cubylglycine and the first examples of cubane C –H insertion are reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2019 Category: Molecular Biology Authors: Sevan D. Houston Source Type: research

DNA Dumbbell Tiles with Uneven Widths for 2D Arrays
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02709A, PaperMashooq Ali, Noshin Afshan, Chuan Jiang, Shou-Jun Xiao Small DNA tiles built from linear oligonucleotides for construction of DNA nanostructures often have even widths in the lateral direction against the DNA double helical axis. Herein we present an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2019 Category: Molecular Biology Authors: Mashooq Ali Source Type: research

Iron-catalyzed asymmetric intramolecular cyclopropanation reactions using chiral tetramethyl-1,1 ′-spirobiindane-based bisoxazoline (TMSI-BOX) ligands
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03065K, PaperHaorui Gu, Shaoying Huang, Xufeng Lin Fe complexes of TMSI-BOX based on the tetramethyl-1,1 ′-spirobiindane backbone have been developed and applied in catalytic highly enantioselective intramolecular cyclopropanation reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2019 Category: Molecular Biology Authors: Haorui Gu Source Type: research

SuperQuat chiral auxiliaries: design, synthesis, and utility
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02819B, Review ArticleStephen G. Davies, Ai M. Fletcher, Paul M. Roberts, James E. Thomson The design, synthesis and outline of some of the most common synthetic applications of the SuperQuat (4-substituted 5,5-dimethyloxazolidine-2-one) family of chiral auxiliaries, developed to address the shortcomings of the Evans (4-substituted oxazolidin-2-one) family of chiral auxiliaries, are presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Orga...
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Stephen G. Davies Source Type: research

Silver(I)-catalyzed addition of pyridine-N-oxides to alkynes: a practical approach for N-alkenoxypyridinium salts
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02907E, PaperXiaodong Tang, Nan Wu, Rongliang Zhai, Zheng Wu, Jiajia Mi, Renshi Luo, Zhou Xu A smooth catalytic approach toN-alkenoxypyridinium salts using pyridine-N-oxides as the nucleophilic partner with alkynes under acidic conditions was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Xiaodong Tang Source Type: research

Synthesis of biurets via TMSNCO addition to 1-aminosugars: application in the de novo synthesis of dC oxidation products
We report an efficient one-step transformation of amines to biurets that has been applied to a number of 1-aminosugars and has led to thede novo synthesis of dfBU and dpBU, two known oxidatively produced lesions of 2 ′-deoxycytidine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Veronika Tsoulougian Source Type: research

Design, synthesis and glycosidase inhibition studies of novel triazole fused iminocyclitol- δ-lactams
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03084G, PaperVenkatesan Santhanam, Pradeep Pant, B. Jayaram, Namakkal G. Ramesh Synthesis of novel triazole fused iminocyclitol- δ-lactams, from tri-O-benzyl-D-glucal, involving intermolecular [3 + 2]cycloaddition and intramolecular lactamisation reactions as key steps is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Venkatesan Santhanam Source Type: research

A one-pot metal-free protocol for the synthesis of chalcogenated furans from 1,4-enediones and thiols
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03051K, PaperVenkatachalam Rajeshkumar, Chinnaraj Neelamegam, Sambandam Anandan Transition-metal-free synthesis of chalcogenated furans through the sequential thiol-Michael/Paal –Knorr reaction of 1,4-enediones in the presence of a catalytic amount ofp-toluene sulfonic acid has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Venkatachalam Rajeshkumar Source Type: research

Synthesis of cyano-substituted carbazoles via successive C –C/C–H cleavage
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03031F, PaperYajie Yang, Jiaqi Huang, Hailu Tan, Lingkai Kong, Mengdan Wang, Yang Yuan, Yanzhong Li Cs2CO3 promoted C –C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C–H and/or C–C bond activations towards cyano carbazoles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Yajie Yang Source Type: research

Applications of N ′-monofunctionalised TsDPEN derivatives in asymmetric catalysis
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02889C, Review ArticleJonathan Barrios-Rivera, Yingjian Xu, Martin Wills N′-Monoalkylated orN′-mono(thio)acylated(N-sulfonyl)-1,2-diphenylethylene-1,2-diamine (TsDPEN) derivatives are have found extensive applications in asymmetric catalysis of a wide range of synthetic applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Jonathan Barrios-Rivera Source Type: research

Kinetic and spectroscopic studies on the chiral self-aggregation of amphiphilic zinc and copper (L)-prolinate-tetraarylporphyrin derivatives in different aqueous media
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02689K, PaperFabrizio Caroleo, Manuela Stefanelli, Gabriele Magna, Mariano Venanzi, Roberto Paolesse, Simona Sennato, Marilena Carbone, Donato Monti The chiral self-aggregation of (L)-proline porphyrin derivatives depends on both the nature of the media and the coordinated metal ion. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Fabrizio Caroleo Source Type: research

From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02990C, PaperMiryam Pastor, Jos é María Zapico, Claire Coderch, Maciej Maslyk, Rostyslav Panchuk, Beatriz de Pascual-Teresa, Ana Ramos In this article, we describe new MMP13 inhibitors, active at low nanomolar concentrations, and with a novel TBB-derived scaffold. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Miryam Pastor Source Type: research

The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Atefeh Mohammadi, Laila Kudsiova, M. Firouz Mohd Mustapa, Frederick Campbell, Danielle Vlaho, Katharina Welser, Harriet Story, Aristides D. Tagalakis, Stephen L. Hart, David J. Barlow, Alethea B. Tabor, M. Jayne Lawrence, Helen C. Hailes Novel trichain lipids have been identified with enhanced transfection properties in lipopolyplexes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Atefeh Mohammadi Source Type: research

Design criteria for minimalist mimics of protein –protein interface segments
We present several critical design criteria of minimalist peptidomimetics deducedvia extensive computational and data-mining studies on nine representative mimic designs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Jaru Taechalertpaisarn Source Type: research

Metal-free oxysulfonylation and aminosulfonylation of alkenyl oximes: synthesis of sulfonylated isoxazolines and cyclic nitrones
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02879F, PaperZhong-Qi Xu, Lin-Chuang Zheng, Lin Li, Lili Duan, Yue-Ming Li Sulfonylated isoxazolines and cyclic nitrones were obtained in moderate to excellent yieldsvia iodine-catalyzed oxysulfonylation and aminosulfonylation of alkenyl oximes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Zhong-Qi Xu Source Type: research

Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02846J, PaperTaro Ozaki, Ryosuke Sugiyama, Morito Shimomura, Shinichi Nishimura, Shumpei Asamizu, Yohei Katsuyama, Hideaki Kakeya, Hiroyasu Onaka The new subfamily of type II PKS gene cluster is responsible for biosynthesis of structurally distinct streptoaminals (STAMs) and 5-alkyl-1,2,3,4-tetrahydroquinolines (5aTHQs). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Taro Ozaki Source Type: research

The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02533A, CommunicationLi-Hua Du, Zhen Dong, Rui-Jie Long, Ping-Feng Chen, Miao Xue, Xi-Ping Luo A fast and green Michael addition based protocol in a continuous flow microreactor was developed, an innovation which may open up the use of enzymatic microreactors in imidazole analogue biotransformations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Li-Hua Du Source Type: research

Glycosylated naphthalimides and naphthalimide Tr öger's bases as fluorescent aggregation probes for Con A
We report the synthesis of glycosylated naphthalimide compounds and their application as fluorescent probes for Concanavalin A (Con A) lectin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Elena Calatrava-P érez Source Type: research

A catalyst-free four-component domino reaction for the synthesis of functionalized 3-acyl-1,5-benzodiazepines
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02903B, PaperYue-Wei Sun, Yue-Ming Bei, Lan-Zhi Wang Various functional 3-acyl-1,5-benzodiazepines were synthesizedvia a catalyst-free four-component domino reaction. A total of 26 examples were examined by reacting inexpensive starting materials ofN,N-dimethylformamide dimethyl acetal, aromatic ketones, 1,2-phenylenediamine compounds and aldehyde derivatives in high yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Yue-Wei Sun Source Type: research

Pseudo five component reaction towards densely functionalized spiro[indole-3,2'-pyrrole] by picric acid, an efficient syn-diastereoselective catalyst: An insight to the diastereoselection on C(sp3)-C(sp3) axial conformation
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02849D, PaperAyon Sengupta, Suvendu Maity, Animesh Mondal, Prasanta Ghosh, Sonali Rudra, Chhanda Mukhopadhyay A new series of highly functionalized spiro compounds of pyrrole were synthesized by a one pot, step-economic condensation of isatin, arylamine and β-keto ester catalyzed by wet picric acid. Initially,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Ayon Sengupta Source Type: research

Saturated Bioisosteres of Benzene: Where to go Next?
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02812E, Review ArticlePavel K. Mykhailiuk The replacement of para-substituted benzenes with the saturated bioisosteres increases the potency, selectivity and metabolic stability of bioactive compounds. The current challenge for chemists is to rationally design, synthesize and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2019 Category: Molecular Biology Authors: Pavel K. Mykhailiuk Source Type: research

Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02900H, PaperReiya Ohta, Akihiro Oguro, Kazuhiro Nishimura, Kenichi Murai, Hiromichi Fujioka, Mitsuhiro Arisawa The synthesis of newN1,N8-diacetylspermidine (DiAcSpd) analogues having a linker with desired functional groups in the methylene skeleton, which have been designed by theoretical calculations, is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Reiya Ohta Source Type: research

Synthesis of (2-hydroxyphenyl)(fusedphenyl)methanones via the photo-induced rearrangement of 2 ′-arylisoflavones
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02779J, PaperPei Wang, Jin Zhang, Tao Wang, Yong Liang, Zunting Zhang The photo-induced rearrangement of 2 ′-arylisoflavones (aryl = phenyl, 1-naphenyl, and 2-naphenyl) for the synthesis of (2-hydroxyphenyl)(fusedphenyl)methanones in EtOH under Ar at room temperature has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Pei Wang Source Type: research

Synthesis of 1,3-disubstituted cyclohexenes from dienylethers via sequential hydrozirconation/deoxygenative cyclisation
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02925C, CommunicationAmandine Payet, Benjamin Blondeau, Jean-Bernard Behr, Jean-Luc Vasse The preparation of 1,3-disubstituted cyclohexenes from 3-methoxyhexa-1,5-dienes involving a sequential hydrozirconation/TMSOTf-mediated activation is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Amandine Payet Source Type: research

Silver or cerium-promoted free radical cascade difunctionalization of o-vinylanilides with sodium aryl- or alkylsulfinates
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02964D, CommunicationJilai Wu, Yuanyuan Zong, Chunxia Zhao, Qinqin Yan, Lixian Sun, Yiming Li, Jincan Zhao, Yaxin Ge, Zejiang Li An efficient cascade oxysulfonylation ofo-vinylanilides with sodium aryl- or alkylsulfinates was developed for the synthesis of sulfonated benzoxazines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Jilai Wu Source Type: research

Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02921K, CommunicationShengxiao Li, Xin-Xing Wu, Shufeng Chen A convenient base-promoted cascade benzannulation reaction of allenic ketones with indole derivatives has been established. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Shengxiao Li Source Type: research

Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02758G, CommunicationZhenying Chang, Tamar Ansbacher, Lilan Zhang, Yong Yang, Tzu-Ping Ko, Guimin Zhang, Weidong Liu, Jian-Wen Huang, Longhai Dai, Rey-Ting Guo, Dan Thomas Major, Chun-Chi Chen Crystal structure of LepI, a SAM-dependent enzyme which can catalyze seteroselective dehydration, Diels –Alder reaction, and retro-Claisen rearrangement. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Zhenying Chang Source Type: research

Theoretical studies on the purine radical induced purine –purine type intrastrand cross-links
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02882F, PaperShoushan Wang, Jie Ding, Peng Liu, Shilei Xie, Dong Xie, Min Zhang, Faliang Cheng Purine-type radicals can attack their 3 ′/5′ flanking purine deoxynucleosides forming the purine–purine type DNA intrastrand cross-links. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Shoushan Wang Source Type: research

Scalable Electrochemical Oxidant-and Metal-Free Dehydrogenative Coupling of S-H/N-H
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03211D, CommunicationShanyu Tang, Yan Liu, Longjia Li, Xuanhe Ren, Jiao Li, Guanyu Yang, Heng Li, Bingxin Yuan In this manuscirpt, we have developed a practical and scalable electrochemical oxidation of S-H and N-H. This oxidant- and catalyst-free electrochemical process enables S-N bond formation with inexpensive nickel electrodes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Shanyu Tang Source Type: research

Efficient synthesis of chiral β-hydroxy sulfones via iridium-catalyzed hydrogenation
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02923G, CommunicationLin Tao, Congcong Yin, Xiu-Qin Dong, Xumu Zhang A highly efficient Ir-catalyzed asymmetric hydrogenation of prochiral β-keto sulfones was successfully developed, affording a series of chiral β-hydroxy sulfones with excellent results (up to>99% conversion, 99% yield,>99% ee, and 20  000 TON). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Lin Tao Source Type: research

Mechanism and chemoselectivity origins of bioconjugation of cysteine with Au(III)-aryl reagents
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03143F, PaperSong-Lin Zhang, Jia-Jia Dong Organometallic reagents, in particular Pd(II)- and Au(III)-aryl reagents, have recently been emerging as an efficient tool for bioconjugation. However, the detailed mechanism and origins of chemoselectivity are not well established,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Song-Lin Zhang Source Type: research

HUSY zeolite-promoted reactions of trifluoromethylated propargyl alcohols with arenes: synthesis of CF3-indenes and DFT study of intermediate carbocations
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB02887G, PaperSelbi Nursahedova, Aleksey Zerov, Irina A. Boyarskaya, Elena Grinenko, Valentine Nenajdenko, Aleksander Vasilyev The reaction of CF3-propargyl alcohols [ArC CCH(OH)CF3] with arenes under the action of acidic HUSY zeolite CBV-720 was investigated. It was found that the reaction at 100°C for 1 h gave... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Selbi Nursahedova Source Type: research