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Design and synthesis of (aza)indolyl maleimide-based covalent inhibitors of glycogen synthase kinase 3[small beta]
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00642C, PaperZhimin Yang, Hui Liu, Botao Pan, Fengli He, Zhengying Pan The optimization of both non-covalent interactions and reactive groups led to azaindolyl maleimide compound38b as a selective and covalent inhibitor against GSK3[small beta]. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2018 Category: Molecular Biology Authors: Zhimin Yang Source Type: research

Synthesis of N-[(dialkylamino)methyl]acrylamides and N-[(dialkylamino)methyl]methacrylamides from Schiff base salts: useful building blocks for smart polymers
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdullah Alzahrani, Styliana I. Mirallai, Benjamin A. Chalmers, Patrick McArdle, Fawaz Aldabbagh Schiff base salts are characterized and formN-amino methylated acrylamides and methacrylamides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Abdullah Alzahrani Source Type: research

Chelation-assisted C-N cross-coupling of phosphinamides and aryl boronic acids with copper powder at room temperature
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00907D, CommunicationYao Peng, Jian Lei, Renhua Qiu, Lingteng Peng, Chak-Tong Au, Shuang-Feng Yin A protocol for the chelation-assisted C-N cross-coupling of phosphinamides and aryl boronic acids with copper powder under an oxygen atmosphere is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Yao Peng Source Type: research

A catalyst-controlled switchable reaction of [small beta]-keto acids to silyl glyoxylates
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00740C, PaperMan-Yi Han, Hong Pan, Jing Lin, Wei Li, Pinhua Li, Lei Wang A catalyst-controlled switchable reaction of [small beta]-keto acids to silyl glyoxylates was developed and the decarboxylative-addition products were generated by using a thiourea catalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Man-Yi Han Source Type: research

Design of RGD-ATWLPPR peptide conjugates for the dual targeting of [small alpha]V[small beta]3 integrin and neuropilin-1
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00669E, PaperFabien Thoreau, Laetitia Vanwonterghem, Maxime Henry, Jean-Luc Coll, Didier Boturyn A dual targeting system provides an enhanced tumour-to-background ratio. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Fabien Thoreau Source Type: research

Rapid and reversible hydrazone bioconjugation in cells without the use of extraneous catalysts
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00946E, PaperRahul Nisal, Gregor P. Jose, Chitra Shanbhag, Jeet Kalia The amenability of hydrazone linkages to disassemble via either hydrolysis in mildly acidic aqueous solutions or transimination upon treatment with amine nucleophiles renders them extremely attractive for applications in chemical... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Rahul Nisal Source Type: research

Transient Imines as 'Next Generation' Directing Groups for the Catalytic Functionalisation of C-H Bonds in a Single Operation
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00926K, Review ArticleSahra St John-Campbell, James A Bull C-H Functionalisation promises a paradigm shift in synthetic planning. However, the additional steps often required to install and remove directing groups currently detracts from the efficiency. The strategy of reversible... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Sahra St John-Campbell Source Type: research

Celebrating the work of Young Thousand Talents Plan researchers
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB90069H, Profile Celebrating the work of researchers who are part of the Recruitment Program for Global Young Professionals (known as the "Young Thousand Talents Plan") who published their research inOrganic& Biomolecular Chemistry in 2017. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Source Type: research

Review of synthetic approaches toward maoecrystal V
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00909K, Review ArticleBrandon R. Smith, Jon T. Njardarson Synthetic approaches toward the complex natural product diterpenoid maoecrystal V are reviewed, including successful total syntheses, published synthetic efforts, and efforts compiled from dissertations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Brandon R. Smith Source Type: research

Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00650D, PaperXiaojiang Hao, Yanrong Zeng, Ping Yi, Wei Gu, Chunxia Xiao, Liejun Huang, Dongsong Tian, Hui Yan, Duozhi Chen, Chunmao Yuan Two new 6-norpolycyclic polyprenylated acylphloroglucinols (PPAPs), hypermonins A (1) and B (2), featuring an undescribed decahydroindeno[1,7-bc]furan ring system, were isolated from the leaves and twigs of Hypericum monogynum. These compounds... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Xiaojiang Hao Source Type: research

Energy Transfer Chemiluminescence for Ratiometric pH Imaging
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00972D, PaperWeiwei An, Ralph Mason, Alexander Lippert Chemiluminescence imaging offers a low background and high sensitivty approach to imaging analytes in living cells and animals. Intensity-based measurements have been developed, but require careful consideration of kinetics, probe... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Weiwei An Source Type: research

FeCl3/MeSO3H-Promoted Multicomponent Reactions Facile Synthesis of Structurally Diverse Furan Analogues
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00942B, PaperZhiwei Chen, Xiangqing Chang, Xiongfei Zhang An intriguing conversion of arylglyoxal, cyclic dicarbonyl compounds and phenols to diverse furan analogues under FeCl3 or MeSO3H catalysis is reported. Utilizing this synthetic protocol, a variety of furan analogues... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2018 Category: Molecular Biology Authors: Zhiwei Chen Source Type: research

Base-Controlled Fe(Pc)-Catalyzed Aerobic Oxidation of Thiols for the Synthesis of S-S and S-P(O) Bond
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00908B, CommunicationHai Huang, Jeffrey Ash, Jun Yong Kang A Fe(Pc)-catalyzed aerobic oxidation of thiols for the synthesis of disulfide has been developed under mild reaction conditions. In addition, aerobic oxidative cross-dehydrogenative coupling (CDC) reaction of thiols with P(O)-H... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 17, 2018 Category: Molecular Biology Authors: Hai Huang Source Type: research

Caged cyclopropenes for controlling bioorthogonal reactivity
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01076E, CommunicationPratik Kumar, Ting Jiang, Sining Li, Omar Zainul, Scott T Laughlin Bioorthogonal ligations have been designed and optimized to provide new experimental avenues for understanding biological systems. Generally, these optimizations have focused on improving reaction rates and orthogonality to both biology... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 17, 2018 Category: Molecular Biology Authors: Pratik Kumar Source Type: research

Anti-Staphylococcal Biofilm Activity of Miconazoctylium Bromide
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00897C, PaperJeremie Tessier, Mahmood Golmohamadi, Kevin J Wilkinson, Andreea R. Schmitzer We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 17, 2018 Category: Molecular Biology Authors: Jeremie Tessier Source Type: research

Cascade double isocyanide insertion and C-N coupling of 2-iodo-2[prime or minute]-isocyano-1,1[prime or minute]-biphenyls
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00956B, CommunicationHongwei Sun, Shi Tang, Dengke Li, Yali Zhou, Jinbo Huang, Qiang Zhu This reaction provides the first example of using a functionalized isocyanide in double insertion to construct nitrogen-containing heterocyclic systems. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Hongwei Sun Source Type: research

Mixed carboxylic-sulfonic anhydride in reaction with imines: a straightforward route to water-soluble [small beta]-lactams via a Staudinger-type reaction
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00768C, PaperOlga Bakulina, Dmitry Dar'in, Mikhail Krasavin The first example of employing a mixed carboxylic-sulfonic anhydride in reaction with imines is reported. It gave [small beta]-lactams, presumably,via a formal [2 + 2] cycloaddition (a Staudinger-type reaction). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Olga Bakulina Source Type: research

Copper-catalyzed ambient-temperature decarboxylative aunulation of isatins with amidine hydrochlorides: a facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00904J, CommunicationFeng-Cheng Jia, Cheng Xu, Yu-Wei Wang, Zhi-Peng Chen, Yunfeng Chen, An-Xin Wu A copper-catalyzed cascade reaction using isatins and amidine hydrochlorides for the synthesis of 2-(1,3,5-triazin-2-yl)aniline derivatives has been developed. This reaction features commercially available starting materials, mild reaction conditions and good... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Feng-Cheng Jia Source Type: research

Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00877A, CommunicationQian Chen, Guodian Yu, Xiaofeng Wang, Yulin Huang, Yan Yan, Yanping Huo An efficient halogen-free Cs2CO3-promoted methylene insertion into disulfide bonds has been achieved using acetone as a methylene source under mild conditions. This method provides a convenient and practical route to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Qian Chen Source Type: research

Mechanistic understanding of [Rh(NHC)]-catalyzed intramolecular [5+2] cycloadditions of vinyloxiranes and vinylcyclopropanes with alkynes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01117F, PaperHuan Zhou, Botao Wu, Jun-An Ma, Yanfeng Dang Zhang and co-workers have recently advanced the carbon [5+2] cycloaddition of vinylcyclopropane and alkyne (VCP-alkyne) to the hetero-[5+2] cycloaddition of vinyloxirane with alkyne (VOR-alkyne). Herein, we present a systematic computational... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Huan Zhou Source Type: research

Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00981C, CommunicationJing Tan, Penghui Ni, Huawen Huang, Guo-Jun Deng The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2-a]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in highly atom-economic fashion through oxidative... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Jing Tan Source Type: research

Aziridine Based Electrophilic Handle for Asparatic Acid Ligation
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00676H, PaperKiran Bajaj, Devesh S Agarwal, RAJEEV SAKHUJA, GIRINATH G. Pillai A one-pot ligation strategy at aspartic acid junction has been developed by successfully incorporating aziridin-2,3-dicarboxylate to the N-side of a peptide fragment, affording N-aziridine appended peptide, which was ligated in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Kiran Bajaj Source Type: research

QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Emilio Lence, Marc W. van der Kamp, Concepcion Gonzalez-Bello, Adrian J. Mulholland Multiscale simulations pinpoint specific interactions responsible for differences in stabilization of key reacting species in two recognized targets for antibiotic development. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: Emilio Lence Source Type: research

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.S. Shishodia, D. Zhang, A. H. El-Sagheer, T. Brown, T. D. W. Claridge, C. J. Schofield, R. J. Hopkinson NMR studies reveal that formaldehyde, a toxic pollutant and metabolite, reacts with nucleotides to formN-hydroxymethylated adducts of varying stabilities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2018 Category: Molecular Biology Authors: S. Shishodia Source Type: research

Regioselective ortho-Functionalization of Bromofluorenecarbaldehydes using TMPMgCl[middle dot]LiCl
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01072B, CommunicationDominik Gobel, Nils Clamor, Boris Johannes Nachtsheim A highly regioselective functionalization of 7-bromofluorene-2-carbaldehydes, potent organic chromophores, in position C3 using a mild ortho-metallation strategy (DoM) with TMPMgCl[middle dot]LiCl has been developed. This approach allows the preparation of highly... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2018 Category: Molecular Biology Authors: Dominik Gobel Source Type: research

Synthesis of fused tricyclic systems by thermal Cope rearrangement of furan-substituted vinyl cyclopropanes
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Verena Klaus, Stephane Wittmann, Hans M. Senn, J. Stephen Clark A novel method for the construction of hexahydroazuleno[4,5-b]furans has been developed in which 1-furanyl-2-alkenylcyclopropanes undergo highly stereoselective thermal Cope rearrangement. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2018 Category: Molecular Biology Authors: Verena Klaus Source Type: research

A Convergent Strategy to Febrifugine and Related Compounds
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjuctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2018 Category: Molecular Biology Authors: Joseph Harrity Source Type: research

Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01087K, CommunicationHai Yu, Abhishek Santra, Yanhong Li, John B. McArthur, Tamashree Ghosh, Xiaoxiao Yang, Peng George Wang, Xi Chen A highly efficient streamlined chemoenzymatic strategy for total synthesis of four prioritized ganglioside cancer antigens GD2, GD3, fucosyl GM1, and GM3 from commercially available lactose and phytosphingosine is demonstrated. Lactosyl... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2018 Category: Molecular Biology Authors: Hai Yu Source Type: research

Biosynthesis of the teleocidin-type terpenoid indole alkaloids
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00803E, Review ArticleTakayoshi Awakawa, Ikuro Abe Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. Its unique structure and bioactivity have drawn... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2018 Category: Molecular Biology Authors: Takayoshi Awakawa Source Type: research

Design of RGD-ATWLPPR peptide conjugates for dual targeting of [small alpha]V[small beta]3 integrin and neuropilin-1
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00669E, PaperFabien Thoreau, Laeticia Falcon, Maxime Henry, Jean-Luc Coll, Didier Boturyn Targeting tumour microenvironment is a promising strategy to detect and/or treat cancer. The design of selective compounds that co-target several receptors frequently overexpressed in solid tumours may allow a reliable... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2018 Category: Molecular Biology Authors: Fabien Thoreau Source Type: research

Synthesis of N-alkylated 2-Pyridones through Pummerer Type Reactions of Activated Sulfoxides and 2-Fluoropyridine Derivatives
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00860D, PaperGang Hu, Jiaxi Xu, Pingfan Li N-alkylated 2-pyridone products were obtained in good to excellent yields through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride activated sulfoxides and 2-fluoropyridine derivatives, followed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2018 Category: Molecular Biology Authors: Gang Hu Source Type: research

Nitric Oxide Release From a Cucurbituril Encapsulated NO-Donor
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00895G, PaperAngel Acuna, Nuno Basilio, Mercedes Parajo, Juan C. C Mejuto, Jorge Perez-Juste, Patricia Taladriz-Blanco, Luis Garcia Rio Controlling S-nitrosothiols decomposition, with the consequent release of nitric oxide, is a topic of great research effort. Nitrosomercaptopyridine (SNO+) incorporation into cucurbit[7]uril cavity results in a large increase of its... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 11, 2018 Category: Molecular Biology Authors: Angel Acuna Source Type: research

Highly regioselective, electrophile induced cyclizations of 2-(prop-1-ynyl)benzamides
We report an electrophile promoted, highly regioselective ([similar]100%) synthesis of 5-membered haloimidiates from 2-(1-alkynyl)benzamides under metal free conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Bhavani Shankar Chinta Source Type: research

A rhodamine-based turn-on nitric oxide sensor in aqueous medium with endogenous cell imaging: an unusual formation of nitrosohydroxylamine
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00822A, PaperRabiul Alam, Abu Saleh Musha Islam, Mihir Sasmal, Atul Katarkar, Mahammad Ali The sensorL3 selectively recognizes NO in purely aqueous medium with an unusual formation of nitrosohydroxylamine with a turn-on fluorescence response which might be suitable forin vivo application. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Rabiul Alam Source Type: research

A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of [small beta]-ketoesters to nitroolefins
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00773J, PaperGuanghui Chen, Guojuan Liang, Yiwu Wang, Ping Deng, Hui Zhou A homodinuclear Co2/aminophenol sulfonamide complex has been developed for the asymmetric Michael reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Guanghui Chen Source Type: research

Regioselective nitration of anilines with Fe(NO3)3[middle dot]9H2O as a promoter and a nitro source
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00841H, CommunicationYang Gao, Yuanyou Mao, Biwei Zhang, Yingying Zhan, Yanping Huo A novel and efficientortho-nitration reaction of aniline derivatives using the inexpensive and nontoxic Fe(NO3)3[middle dot]9H2O as a promoter and a nitro source has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Yang Gao Source Type: research

Catalyst-controlled switchable reaction of [small beta]-keto acids to silyl glyoxylates
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00740C, PaperMan-Yi Han, Hong Pan, Jing Lin, Wei Li, Pinhua Li, Lei Wang A catalyst-controlled switchable reaction of [small beta]-keto acids to silyl glyoxylate was developed under mild conditions, yielding two distinct products in good yields. Compared to decarboxylative addition-Brook rearrangement, the decarboxylative addition... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Man-Yi Han Source Type: research

Synthetic studies toward marine metabolite prorocentin-4: Synthesis of the C1-C23 fragment
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00388B, PaperSabitha Gowravaram, Praveen AnkiReddy, Sandeep Reddy AnkiReddy A synthetic study on the construction of the C1-C23 fragment of prorocentin-4, a novel linear polyketide is described. The synthetic highlights include acid catalyzed epoxide opening, Gilman reaction, Pd(OH)2 catalyzed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Sabitha Gowravaram Source Type: research

Time-lapse monitoring of TLR2 ligand internalization with newly developed fluorescent probes
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03205F, PaperYohei Arai, Kouhei Yokoyama, Yuki Kawahara, Qi Feng, Ippei Ohta, Atsushi Shimoyama, Shinsuke Inuki, Koichi Fukase, Kazuya Kabayama, Yukari Fujimoto Bacterial lipopeptide fluorescent probes were developed as TLR2 ligands, and their time-lapse monitoring of cellular internalization was performed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Yohei Arai Source Type: research

Chelation-Assisted C-N Cross-Coupling of Phosphinamides and Aryl Bronic Acids with Copper Powder at Room Temperature
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00907D, CommunicationYao Peng, Jian Lei, Renhua Qiu, Lingteng Peng, Chak-Tong Au, Shuang-Feng Yin A protocol for chelation-assisted C-N cross-coupling of phosphinamides and aryl boronic acids with copper powder under oxygen atmosphere is reported. The reaction proceeds efficiently to afford fully substituted unsymmetrical N-arylation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Yao Peng Source Type: research

Promoter Free Allylation of Trichloroacetimidates with Allyltributylstannanes Under Thermal Conditions to Access the Common 1,1'-Diarylbutyl Pharmacophore
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00687C, PaperNivedita S Mahajani, John D Chisholm 1,1'-Diarylbutyl groups are a common pharmacophore found in many biologically active small molecules. To access these systems under mild conditions, the reaction of diarylmethyl trichloroacetimidates with allyltributylstannanes was explored. Simply... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 10, 2018 Category: Molecular Biology Authors: Nivedita S Mahajani Source Type: research

Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00889B, CommunicationJian Zhang, Weiwei Jin, Cungui Cheng, Fang Luo A Cu-catalyzed oxidation of alcohols triggered by the radical difluoroalkylation of alkenes has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 9, 2018 Category: Molecular Biology Authors: Jian Zhang Source Type: research

Comparison of Riboflavin-Derived Flavinium Salts Applied to Catalytic H2O2 Oxidations
This study presents a comparison between their optical and redox properties, and their... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 9, 2018 Category: Molecular Biology Authors: Takuya Sakai Source Type: research

Construction of the tetracyclic core of (+/-)-cycloclavine and 4-amino Uhle's ketone
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03067C, PaperJin-Quan Chen, Yang Mi, Zi-Fa Shi, Xiao-Ping Cao Construction of the tetracyclic core of (+/-)-cycloclavine and 4-amino Uhle's ketone. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 9, 2018 Category: Molecular Biology Authors: Jin-Quan Chen Source Type: research

Facile Synthesis of 2,3-Benzodiazepines Using One-pot Two-step Phosphate-Assisted Acylation-Hydrazine Cyclization Reactions
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00708J, PaperAkinari Sumita, Jinhee Lee, Yuko Otani, Tomohiko Ohwada Here, we report new methodology for synthesizing 2,3-benzodiazepines and their analogues by means of phosphate-assisted acylation reaction of 1-arylpropan-2-ones with a carboxylic acid followed by hydrazine cyclization in a one-pot... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 9, 2018 Category: Molecular Biology Authors: Akinari Sumita Source Type: research

Synthesis of N-[(dialkylamino)methyl)]acrylamides and N-[(dialkylamino)methyl]methacrylamides from Schiff base salts: Useful Building Blocks for Smart Polymers
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdullah Alzahrani, Styliana I Mirallai, Benjamin A Chalmers, Patrick McArdle, Fawaz Aldabbagh The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these monomeric precursors to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 9, 2018 Category: Molecular Biology Authors: Abdullah Alzahrani Source Type: research

Halo-substituted benzenesulfonyls and benzenesulfinates: Convenient sources of arenes in metal-catalyzed C-C bond formation reactions for the straightforward access to halo-substituted arenes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00632F, Review ArticleHaoran Li, Arpan Sasmal, Xinzhe Shi, Jean-Francois Soule, Henri Doucet Palladium-catalyzed reactions using aryl halides as one of the coupling partners represent a very popular method for generating carbon-carbon bonds. However, such couplings suffer of important limitations. As most palladium... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 9, 2018 Category: Molecular Biology Authors: Haoran Li Source Type: research

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00890F, CommunicationMuhammad Jbara, Emad Eid, Ashraf Brik An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 8, 2018 Category: Molecular Biology Authors: Muhammad Jbara Source Type: research

Reactive group effects on the photophysical and biological properties of 2-phenyl-1H-phenanthro[9,10-d]imidazole derivatives as fluorescent markers
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00729B, PaperPrzemyslaw Krawczyk, Przemyslaw Czelen, Piotr Cysewski The presence of a pyridyl disulfide group limits the use of phenanthroimidazole derivatives in medical imaging, while the introduction of anN-hydroxysuccinimide ester along with changes to the PhI backbone may be used to create valuable fluorescent probes for applications in biomedical imaging. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 8, 2018 Category: Molecular Biology Authors: Przemyslaw Krawczyk Source Type: research

Diselenoamino acid derivatives as GPx mimics and as substrates of TrxR: in vitro and in silico studies
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00451J, PaperJessie Haigert Sudati, Pablo Andrei Nogara, Rogerio Aquino Saraiva, Caroline Wagner, Eduardo Eliezer Alberto, Antonio Luiz Braga, Roselei Fachinetto, Paulo Cesar Piquini, Joao Batista Teixeira Rocha The antioxidants diselenoamino acid derivatives from phenylalanine and valine are mimetics of GPx and substrate of TrxR. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 8, 2018 Category: Molecular Biology Authors: Jessie Haigert Sudati Source Type: research