Pd-Catalyzed C(sp2)-H Aminocarbonylation Using Langlois Reagent as Carbonyl Source
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01421C, PaperXiao-Fang Li, Lin-Feng Shi, Xing-Guo Zhang, xiaohong zhang An efficient Pd-catalyzed C(sp2)-H aminocarbonylation of aryl carboxamides assisted by N, S-bidentate directing group was developed. The readily available sodium trifluoromethanesulfinate was firstly utilized as CO surrogate. A variety of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 16, 2018 Category: Molecular Biology Authors: Xiao-Fang Li Source Type: research

Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jean-Louis Duprey, Dario Bassani, Eva I Hyde, Gediminas Jonusauskas, Christian Ludwig, Alison Rodger, Neil Spencer, Joseph S. Vyle, John Wilkie, John Zhao, J H R Tucker The labelling of DNA oligonucleotides with signalling groups that give a unique response to duplex formation depending on the target sequence is a highly effective strategy in the design of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 16, 2018 Category: Molecular Biology Authors: Jean-Louis Duprey Source Type: research

Palladium-Catalyzed Salt-Free Double Decarboxylative Aryl Allylation
This report describes a palladium-catalyzed decarboxylative aryl allylation between unactivated benzoic acids and allylic carbonates. This transformation successfully couples a variety of carbonates and benzoic acids in good yield (up... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 16, 2018 Category: Molecular Biology Authors: Ryan A. Daley Source Type: research

Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01565A, PaperSean Newmister, Stelamar Romminger, Jennifer J. Schmidt, Janet L L Smith, Robert Michael Williams, Roberto Berlinck, David H. Sherman Antimicrobial and anti-proliferative meleagrin and oxaline are roquefortine C-derived alkaloids produced by fungi of the genus Penicillium. Tandem O-methylations complete the biosynthesis of oxaline from glandicoline B through meleagrin. Currently,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 15, 2018 Category: Molecular Biology Authors: Sean Newmister Source Type: research

Target-Protein-Selective Inactivation and Labelling Using Oxidative Catalyst
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01484A, Review ArticleShinichi Sato, Michihiro Tsushima, Hiroyuki Nakamura Reactive oxygen species (ROS) and radical species generated using oxidative single-electron transfer (SET) catalysts are highly reactive, inducing local environmental oxidative reactions, resulting in protein inactivation and labelling in proximity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 15, 2018 Category: Molecular Biology Authors: Shinichi Sato Source Type: research

Syntheses of 12H-Benzo[a]xanthen-12-ones and Benzo[a]acridin- 12(7H)-ones through Au(I)-Catalyzed Michael Addition/6-Endo-Trig Cyclization/Aromatization Cascade Annulation
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01684D, PaperZhiling Xiong, Xinhang Zhang, Yangming Li, Xiaoshi Peng, Jiayue Fu, Jiajia Guo, Chongguo Jiang, Fukai Xie, Bin Lin, Yongxiang Liu, Mao-sheng Cheng A multifaced gold(I)-catalyzed aromaticity-drived double 6-endo cascade cyclization strategy to synthesize both 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones, whose core motifs xanthone and acridone both exist as important scaffolds in immense number of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 15, 2018 Category: Molecular Biology Authors: Zhiling Xiong Source Type: research

Cesium carbonate-promoted synthesis of aryl methyl sulfides using S-methylisothiourea sulfate under transition-metal-free conditions
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01758A, PaperCaiyang Zhang, You Zhou, Jintao Huang, Canhui Tu, Xiaoai Zhou, Guodong Yin In the presence of cesium carbonate, an efficient synthesis of aryl methyl sulfides by the reactions of aryl halides with commercially available S-methylisothiourea sulfate is developed. This odourless and highly... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 15, 2018 Category: Molecular Biology Authors: Caiyang Zhang Source Type: research

Silver-catalyzed intermolecular amination of fluoroarenes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01749B, CommunicationYu Wang, Chenlong Wei, Ruyun Tang, Haosheng Zhan, Jing Lin, Zhenhua Liu, Weihua Tao, Zhongxue Fang A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C −F... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 15, 2018 Category: Molecular Biology Authors: Yu Wang Source Type: research

Copper(I)-Catalysed Stereoselective Debromoborylation of Aliphatic 1,1-Dibromo-1-Alkenes with Bis(pinacolato)diboron
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01778F, CommunicationYadong Pang, Ryoto Kojima, Hajime Ito A stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes to prepare (Z)-1-bromo-1-alkenylboronate esters using copper(I) catalysts was developed. The debromoborylation of various aliphatic 1,1-dibromo-1-alkenes in the presence of a copper(I) catalyst and bis(pinacolato)diboron... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 15, 2018 Category: Molecular Biology Authors: Yadong Pang Source Type: research

Molecular tweezers with a rotationally restricted linker and freely rotating porphyrin moieties
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Rhys B. Murphy, Duc-Truc Pham, Jonathan M. White, Stephen F. Lincoln, Martin R. Johnston The different host –guest behaviour of non-interconvertible bis-porphyrin tweezer isomers was examined, contributing to ongoing discussions regarding rigidity/flexibility and preorganisation in synthetic receptors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 14, 2018 Category: Molecular Biology Authors: Rhys B. Murphy Source Type: research

Chloroform as carbon monoxide source in Palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a] pyridines
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01486H, PaperNitha P R, Manu M Joseph, Greeshma Gopalan, Kaustabh Maiti, Radhakrishnan K. V., Parthasarathi Das Palladium-catalyzed aminocarbonylation strategy exploiting chloroform as CO surrogate has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 14, 2018 Category: Molecular Biology Authors: Nitha P R Source Type: research

Rational Design of a Highly Reactive Dicysteine Peptide Tag For Fluorogenic Protein Labelling
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01417E, PaperMiroslava Strmiskova, Kelvin Tsao, Jeffrey W Keillor Rationally designed libraries of a short helical peptide sequence containing two cysteine residues were screened kinetically for their reactivity towards complementary dimaleimide fluorogens. This screening revealed variant sequences whose reactivity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 14, 2018 Category: Molecular Biology Authors: Miroslava Strmiskova Source Type: research

Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01798K, PaperJihyun Hwang, Taeho Kang, Janghyun Lee, Byong-seok Choi, Sunkyu Han STING, a central protein in the innate immune response to cytosolic DNA, has emerged as a hot target for the development of vaccine-adjuvants and anticancer drugs. The discovery of potent... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 14, 2018 Category: Molecular Biology Authors: Jihyun Hwang Source Type: research

Chemoselective N –H functionalization of indole derivatives via the Reissert-type reaction catalyzed by a chiral phosphoric acid
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01863D, PaperYue Cai, Qing Gu, Shu-Li You An asymmetricN-alkylation of indole derivativesvia the Reissert-type reaction was realized in the presence of 10 mol% chiral phosphoric acid. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 13, 2018 Category: Molecular Biology Authors: Yue Cai Source Type: research

Building of neomycin-nucleobase-amino acid conjugates for the inhibition of oncogenic miRNAs biogenesis.
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01858H, PaperDuc Duy Vo, C écile Becquart, Thi Phuong Anh Tran, Audrey Di Giorgio, Fabien Darfeuille, cathy staedel, Maria Duca MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicates that miRNAs are aberrantly expressed in a variety... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 13, 2018 Category: Molecular Biology Authors: Duc Duy Vo Source Type: research

TsOH ·H2O-mediated N-amidation of quinoline N-oxides: facile and regioselective synthesis of N-(quinolin-2-yl)amides
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00862K, PaperXinghua Chen, Mei Peng, Hao Huang, Yangfan Zheng, Xiaojun Tao, Chunlian He, Yi Xiao An operationally simple method with 100% atom economy was developed for the synthesis of variousN-(quinolin-2-yl)amidesvia the TsOH ·H2O-mediatedN-amidation of quinolineN-oxides using inexpensive and commercially available nitriles as the amidation reagents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 13, 2018 Category: Molecular Biology Authors: Xinghua Chen Source Type: research

2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01774C, CommunicationKeiichiro Tateishi, Keiichi Noguchi, Akio Saito 2-Picoline efficiently catalyzes the formation of α,β-enones from acetylenedicarboxylates and aldehydes in the presence of alkenes, thereby leading to pyrans with complete regioselectivities. This method is represented as a first example of catalytic and metal-free [2 + 2 + 2] cycloaddition of three different components. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC ...
Source: RSC - Organic and Biomolecular Chemistry - August 10, 2018 Category: Molecular Biology Authors: Keiichiro Tateishi Source Type: research

Functionalization of Diazotetronic Acid and Application in a Stereoselective Modular Synthesis of Pulvinone, Aspulvinones A-E, G, Q and their Analogues
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01511B, PaperAmarender Manchoju, Ritesh A. Annadate, Lise Desquien, Sunil Vasant Pansare A modular synthesis of aspulvinones A, B, C, D, E, G and the recently isolated aspulvinone Q was developed. The methodology features a highly stereoselective aldol condensation of diazotetronic acid... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 10, 2018 Category: Molecular Biology Authors: Amarender Manchoju Source Type: research

Correction: Synthesis of highly substituted 2-spiropiperidines
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Samuel D. Griggs, Nathan Thompson, Daniel T. Tape, Marie Fabre, Paul A. Clarke To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 10, 2018 Category: Molecular Biology Authors: Samuel D. Griggs Source Type: research

o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01330F, PaperE. Abou Nakad, F. Bolze, A. Specht o-Nitrobenzyl photoremovable groups are able to generate a fluorescent uncaging side-product. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 10, 2018 Category: Molecular Biology Authors: E. Abou Nakad Source Type: research

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01627E, PaperPaul P Geurink, Huib Ovaa, Bo-Tao Xin, Bianca D.M. van Tol The development of γ-thionorleucine (ThioNle) as handle for native chemical ligation-desulfurization is reported here. ThioNle is a new addition to the expanding thiolated amino acid toolbox and serves as methionine... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 10, 2018 Category: Molecular Biology Authors: Paul P Geurink Source Type: research

One-pot synthesis of β-lactams by the Ugi and Michael addition cascade reaction
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01176A, PaperXing Gao, Chunhui Shan, Zhihao Chen, Yan Liu, Xia Zhao, Ao Zhang, Peng Yu, Herv é Galons, Yu Lan, Kui Lu A diversity-oriented synthesis of β-lactamsvia Ugi/Michael reaction cascades under mild conditions was achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 9, 2018 Category: Molecular Biology Authors: Xing Gao Source Type: research

Tandem Diels –Alder/oxidation–aromatization reactions involving 2-styrylchromones and arynes
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01199K, PaperYesu Addepalli, Zhimei Yu, Jie Ji, Cheng Zou, Zhen Wang, Yun He Transition-metal-free tandem Diels –Alder/oxidation–aromatization reactions between 2-styrylchromones and arynes have been demonstrated, providing a wide range of benzo[c]xanthone derivatives with good yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 9, 2018 Category: Molecular Biology Authors: Yesu Addepalli Source Type: research

Correction: Dibenzofuran-4,6-bis(oxazoline) (DBFOX). A novel trans-chelating bis(oxazoline) ligand for asymmetric reactions
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Kennosuke Itoh, Mukund P. Sibi To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 9, 2018 Category: Molecular Biology Authors: Kennosuke Itoh Source Type: research

Stepwise triple-click functionalization of synthetic peptides
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Anna Kovalov á, Radek Pohl, Milan Vrabel A sequence of click reactions and selective deprotection steps enables the stepwise synthesis of defined triple-functionalized peptides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 9, 2018 Category: Molecular Biology Authors: Anna Kovalov á Source Type: research

Phosphite-Catalyzed Alkoxycarbonylation of Aryl Diazonium Salts
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01744A, CommunicationXiao-Feng Wu, Jian-Xing Xu, Robert Franke In this communication, an interesting phosphite-catalyzed alkoxycarbonyaltion of aryl diazonium salts has been reported. At room temperature, under CO pressure, moderate to good yields of the desired esters can be... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 9, 2018 Category: Molecular Biology Authors: Xiao-Feng Wu Source Type: research

Iodine-mediated cross-dehydrogenative coupling of pyrazolones and alkenes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01645C, PaperBaomin Wang, Kai Yang, Xiaoze Bao, Ye Yao, Jingping Qu An iodine-mediated alkenylation of pyrazolones with simple alkenes under an air atmosphere has been developed. By this protocol, the pharmaceutically revelant pyrazolone scaffold was direcrectly adorned with a readily transformable... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 9, 2018 Category: Molecular Biology Authors: Baomin Wang Source Type: research

Synthesis of 2-substituted 3-chlorobenzofurans via TMSCl-mediated nucleophilic annulation of isatin-derived propargylic alcohols
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01731J, PaperZhou Sun, Kuirong Xiang, Hua Tao, Liqun Guo, Ying Li A TMSCl-mediated cascade annulation of isatin-derived propargylic alcohols for the synthesis of 2-substituted 3-chlorobenzofurans is now reported. Mechanistic investigations showed that this proceeded through a sequential Meyer –Schuster rearrangement/nucleophilic addition/intramolecular annulation.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 8, 2018 Category: Molecular Biology Authors: Zhou Sun Source Type: research

Selectfluor-induced C(sp2) –O coupling reaction of N-substituted anilines with hydroxylamine derivatives
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01348A, PaperBin Sun, Shi Yin, Xiaohui Zhuang, Can Jin, Weike Su We developed a novel metal-free method for the construction of C(sp2) –O bondsvia oxidative cross-coupling reactions between variousN-substituted anilines and hydroxylamine derivatives just using commercially available Selectfluor as an oxidant. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 8, 2018 Category: Molecular Biology Authors: Bin Sun Source Type: research

Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01557K, CommunicationJing Wu, Yuanfang Kong, Lingyan Liu, Weixing Chang, Jing Li A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 8, 2018 Category: Molecular Biology Authors: Jing Wu Source Type: research

Nickel-catalyzed direct C –H bond sulfenylation of acylhydrazines
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01481G, PaperJun-Ming Li, Yang Yu, Jiang Weng, Gui Lu An efficient Ni-catalyzed direct C –H bond sulfenylation of acylhydrazines for the synthesis of diverse diaryl sulfides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 8, 2018 Category: Molecular Biology Authors: Jun-Ming Li Source Type: research

Copper-catalyzed generation of flavone selenide and thioether derivatives using KSeCN and KSCN via C –H functionalization
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01398E, PaperJie Zhu, Baojun Xu, Jingjing Yu, Yaokun Ren, Jin Wang, Ping Xie, Charles U. Pittman, Aihua Zhou Two simple Cu-catalyzed methods using KSeCN and KSCN to construct C –Se and C–S bonds on flavone skeletal structuresvia C –H functionalization are developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Jie Zhu Source Type: research

Structure –activity relationship of novel low-generation dendrimers for gene delivery
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01767K, PaperYong-Guang Gao, Xiao Lin, Kai Dang, Shan-Feng Jiang, Ye Tian, Fen-Li Liu, Di-Jie Li, Yu Li, Zhi-Ping Miao, Ai-Rong Qian Structure –activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Yong-Guang Gao Source Type: research

Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro-oxazocinodiindoles
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB00865E, PaperNicholas M. Butler, Rudi Hendra, John B. Bremner, Anthony C. Willis, Leonardo Lucantoni, Vicky M. Avery, Paul A. Keller Cascade reactions of indigo with strained electrophiles affords access to previously unknown oxazocino, pyrazino, and diazepino diindoles with selective anti-plasmodial activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Nicholas M. Butler Source Type: research

Chiral β3-isocyanopropionates for multicomponent synthesis of peptides and depsipeptides containing a β-amino acid fragment
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01507D, PaperDanil P. Zarezin, Olga I. Shmatova, Valentine G. Nenajdenko Chiral β3-isocyanopropionic acids derivatives is a new type of isocyanides for multicomponent reactions. The use of these isocyanides in Ugi and Passerini reactions allows to prepare short peptides and depsipeptides with β-amino acid moiety in the structure. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Danil P. Zarezin Source Type: research

Enantioselective total synthesis of decytospolide A and decytospolide B using an Achmatowicz reaction
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01529E, PaperArun K. Ghosh, Hannah M. Simpson, Anne M. Veitschegger Enantioselective syntheses of decytospolides are described using an Achmatowicz rearrangement, transfer hydrogenation and Friedel –Crafts acylation as the key steps. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Arun K. Ghosh Source Type: research

Correction: Chiral NHC-catalyzed 1,3-dipolar [3 + 2] cycloaddition of azomethine imines with α-chloroaldehydes for the synthesis of bicyclic pyrazolidinones
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Limin Yang, Yunbo Lv, Fei Wang, Guofu Zhong To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Limin Yang Source Type: research

Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01433G, PaperIda B Knudsen, Christinne Hedberg, Lucy K Ladefoged, Daisuke Ide, Anne Brink ø, Espen Eikeland, Atsushi Kato, Henrik Helligso Jensen Four new α-glycosidase inhibitors have been synthesized through 5-8 synthetic steps from a common synthetic intermediate obtained through a recently developed carbocyclisation. The compounds were designed as hybrids of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Ida B Knudsen Source Type: research

Synthesis of 2,2-difluoro-homoallylic alcohols via ring-opening of gem-difluorocyclopropane and aerobic oxidation by photo-irradiation in the presence of an organic pigment
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01740A, PaperHiroaki Takenaka, Yoshihiro Masuhara, Kent Narita, Toshiki Nokami, Toshiyuki Itoh We found that aerobic oxidation took place after the visible light-mediated ring-opening reaction of gem-difluorocyclopropane in the presence of an organic dye and amine to furnish 2,2-difluoro-homoallylic alcohols in good... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Hiroaki Takenaka Source Type: research

Ruthenium-catalyzed synthesis of arylethyl 1,3,5-triazines from arylallyl alcohols and biguanides
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01397G, PaperDongmei Cui, Chen Zhang, Ming Zeng, ZhongPao Xie An efficient ruthenium-catalyzed synthesis of alkyl-1,3,5- triazinones from allyl alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated heterocyclic or... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 7, 2018 Category: Molecular Biology Authors: Dongmei Cui Source Type: research

Recent developments in functionalization of acyclic α-keto amides
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01423J, Review ArticleAlagesan Muthukumar, Sangeetha Subramani, G. Sekar α-Keto amide is a key frame in biology, medicinal chemistry and synthetic chemistry as drug molecules and key intermediates. Based on the structural aspect, acyclic α-keto amide has multiple reactive... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 6, 2018 Category: Molecular Biology Authors: Alagesan Muthukumar Source Type: research

Highly sulphated cellulose: A versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01438H, PaperSoma Shekar Dachavaram, Narsimha Penthala, Julie L Calahan, Eric J. Munson, Peter Crooks A mild, efficient and rapid protocol was developed for the deprotection of alcoholic TBDMS ethers using a recyclable, eco-friendly highly sulphated cellulose sulphate acid catalyst in methanol. This acid catalyst... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 6, 2018 Category: Molecular Biology Authors: Soma Shekar Dachavaram Source Type: research

2-Picoline catalyst –triggered [2+2+2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01774C, CommunicationKeiichiro Tateishi, Keiichi Noguchi, Akio Saito 2-Picoline efficiently catalyzes the fomation of α,β-enones from acetylenedicarboxylates and aldehydes in the presence of alkenes, thereby leading pyrans in moderate to good yields with complete regioselectivities. This synthetic method... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 6, 2018 Category: Molecular Biology Authors: Keiichiro Tateishi Source Type: research

Synthesis of imidazopyridine-fused indoles via one-pot sequential Knoevenagel condensation and cross dehydrogenative coupling
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01449C, PaperVikki N Shinde, Shiv Dhiman, R. Krishnan, Dalip Kumar, Anil Kumar A simple and efficient strategy for the synthesis of imidazopyridine-fused indoles has been developed that involves one-pot sequential Knoevenagel condensation of readily available active methylene azoles with N-substituted-1H-indole-3-carboxaldehydes or N-substituted-1H-indole-2-carboxaldehydes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 4, 2018 Category: Molecular Biology Authors: Vikki N Shinde Source Type: research

Quinoline-galactose hybrids bind selectively with high affinity to galectin-8 N-terminal domain
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Kumar Bhaskar Pal, Mukul Mahanti, Xiaoli Huang, Stella Persson, Anders Sundin, Fredrik Zetterberg, Stina Oredsson, Hakon Leffler, Ulf J. Nilsson Quinolines, indolizines, and coumarins are well known structural elements in many biologically active molecules. In this report, we have developed straightforward methods to incorporate quinoline, indolizine, and coumarin structures into... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 4, 2018 Category: Molecular Biology Authors: Kumar Bhaskar Pal Source Type: research

Conjugation of a GM3 lactone mimetic on carbon nanotubes enhances the related inhibition of melanoma-associated metastatic events
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01817K, PaperPaolo Arosio, Giuseppina Comito, Francesco Orsini, Alessandro Lascialfari, Paola Chiarugi, C écilia Ménard-Moyon, Cristina Nativi, Barbara Richichi GM3-ganglioside is known to be involved in melanoma proliferation. In order to modulate metastatic-related events, we have functionalized multi-walled carbon nanotubes (MWCNTs) with multiple copies of a GM3-lactone mimetic. The... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 4, 2018 Category: Molecular Biology Authors: Paolo Arosio Source Type: research

Dihydroindeno[1,2-b]pyrroles: new Al3+ selective off –on chemosensors for bio-imaging in living HepG2 cells
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01411F, PaperKajal Mal, Barnali Naskar, Animesh Mondal, Sanchita Goswami, Chandraday Prodhan, Keya Chaudhuri, Chhanda Mukhopadhyay An approach for the expeditious synthesis of a new Al3+-selective turn-on dihydroindeno[1,2-b]pyrrole probe under environmentally benevolent conditions and its bio-imaging studies on HepG2 cell. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 3, 2018 Category: Molecular Biology Authors: Kajal Mal Source Type: research

A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01252K, PaperGang Xu, Chaodi Tong, Sunliang Cui, Liyan Dai A silver catalyzed domino reaction ofN-cyanamide alkenes and 1,3-dicarbonyls has been developed for the facile synthesis of quinazolinones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 3, 2018 Category: Molecular Biology Authors: Gang Xu Source Type: research

Tsavoenones A –C: unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01280F, PaperThuc-Huy Duong, Mehdi A. Beniddir, Gr égory Genta-Jouve, Thammarat Aree, Marylène Chollet-Krugler, Joël Boustie, Solenn Ferron, Aurélie Sauvager, Huu-Hung Nguyen, Kim-Phi-Phung Nguyen, Warinthorn Chavasiri, Pierre Le Pogam Three racemic polyketides with a novel scaffold are reported from the lichenParmotrema tsavoense. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 3, 2018 Category: Molecular Biology Authors: Thuc-Huy Duong Source Type: research

Palladium-Catalyzed Direct mono-Aroylation of O-Arylmethyl and Aryl Substituted Acetoxime Ethers
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01400K, PaperYafei Ji, Ling-Yan Shao, Zhi Xu, Cun-Ying Wang, xiaopan fu, Miao-Miao Chen, Hong-Wei Liu An efficient palladium-catalyzed ortho-aroylation of O-arylmethyl and aryl substituted acetoxime ethers has been developed in high mono-site selectivity without the need for exogenous ligand. Under the direction of the simple... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - August 3, 2018 Category: Molecular Biology Authors: Yafei Ji Source Type: research