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Pd(II)-catalyzed cascade annulation of N-substituted anilines with CO, NH4OAc and aldehydes to N1-substituted 2,3-dihydroquinazolin-4(1H)-ones
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00055B, PaperXiaopeng Zhang, Qiuyang Pang, Dan Liu, Zhenhua Guo, Guisheng Zhang N1-substituted 2,3-dihydroquinazolin-4(1H)-ones have been synthesizedvia Pd-catalyzed annulation ofN-substituted anilines with CO, NH4OAc and aldehydes, and the reaction features simple raw materials, high step economy, and good product diversity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 20, 2024 Category: Molecular Biology Authors: Xiaopeng Zhang Source Type: research

Albumin-ruthenium catalyst conjugate for bio-orthogonal uncaging of alloc group
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00234B, PaperKimberly S Taylor, Madison M McMonagle, Schaelee C Guy, Ariana M Human-McKinnon, Shumpei Asamizu, Heidi J Fletcher, Bradley W Davis, Takashi Leo Suyama The employment of antibodies as a targeted drug delivery vehicle has proven successful which is exemplified by the emergence of antibody-drug conjugates (ADCs). However, ADCs are not without their shortcomings.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 20, 2024 Category: Molecular Biology Authors: Kimberly S Taylor Source Type: research

A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00120F, CommunicationSeylan Ayan, Adrian M. Rotaru, Esther G. Kaye, Gabrielle Juneau, Sunit Das, Christopher J. Wilds, Andrew A. Beharry A fluorescent chemosensor for O6-methylguanine DNA methyltransferase derived from a non-pseudosubstrate, covalent inhibitor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 20, 2024 Category: Molecular Biology Authors: Seylan Ayan Source Type: research

Weakly acidic pH-responsive liposomal content release induced by histidine-modified agents
In this study, to enhance the endosomal pH control of drug release from... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 19, 2024 Category: Molecular Biology Authors: Ayumi Kashiwada Source Type: research

Iodide-umpolung catalytic system for non-traditional amide coupling from nitroalkanes and amines
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00184B, PaperChun-Lin Chen, Tian-Sih Huang, Po-Hsiang Chang, Che-Sheng Hsu Developing a new catalytic system involves reversing the polarity (umpolung) concept to synthesize amide derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 18, 2024 Category: Molecular Biology Authors: Chun-Lin Chen Source Type: research

Visible-light-induced C –S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00096J, PaperKhushbu Rajput, Vishal Singh, Priya Mahaur, Sundaram Singh, Vandana Srivastava A novel approach for the synthesis of 2,4-disubstituted thiazoles from methyl aryl ketones,N-bromo-succinimide (NBS), and thioamide in water as a green reaction medium through visible-light irradiation is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 18, 2024 Category: Molecular Biology Authors: Khushbu Rajput Source Type: research

Recent advances in spirocyclization of maleimides via transition-metal catalyzed C –H activation
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB01904G, Review ArticleSwadhin Swaraj Acharya, Sagarika Patra, Rojalini Maharana, Manaswini Dash, Liza Mama Barad, Bibhuti Bhusan Parida In recent years, the maleimide scaffold has received a great deal of attention in C –H activation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 18, 2024 Category: Molecular Biology Authors: Swadhin Swaraj Acharya Source Type: research

Hydrosilylation of nitriles and tertiary amides using a zinc precursor
We report the competent and selective hydrosilylation of nitriles and tertiary amides catalyzed by readily available zinc bis(hexamethyldislazide) under solvent-free and mild conditions, making it a sustainable and desirable alternative... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 18, 2024 Category: Molecular Biology Authors: Tarun K. Panda Source Type: research

Biosynthesis of a new skyllamycin analogue in Streptomyces nodosus: a cytochrome P450 forms an epoxide in the cinnamoyl chain
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuhao Song, Jose Amaya, Vidhi C Murarka, Hugo Mendez, Mark Hogan, jimmy muldoon, Paul Evans, Yannick Ortin, Steven Kelly, David Lamb, Thomas Poulos, Patrick Caffrey Activation of a silent gene cluster in Streptomyces nodosus leads to synthesis of a cinnamoyl-containing non-ribosomal peptide (CCNP) that is related to skyllamycins. This novel CCNP was isolated and its... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 18, 2024 Category: Molecular Biology Authors: Yuhao Song Source Type: research

Visible Light-induced Metal-free Cascade Denitrogenative Boryla-tion and Iodination of Nitroarenes
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00309H, PaperFanglin Zhang, JunWei Li, Tian-Shun Duan, Bing Sun An efficient method was developed for one-pot construction of C ‒B and C‒I via visible light-induced transformation from nitroarenes. This protocol relies on the photochemical property of nitroarenes under visible light,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 16, 2024 Category: Molecular Biology Authors: Fanglin Zhang Source Type: research

Identification of BACE-1 inhibitors through directed C(sp3) –H activation on 5-oxo-pyrrolidine-3-carboxylic acid derivatives
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Lorenzo Baldini, Elena Lenci, Cristina Faggi, Andrea Trabocchi Stereochemically dense 5-oxo-pyrrolidines were obtained by combining the Castagnoli –Cushman reaction with directed Pd-catalyzed C(sp3) –H functionalization and enabling the identification of two BACE-1 enzyme inhibitors with sub-micromolar activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 16, 2024 Category: Molecular Biology Authors: Lorenzo Baldini Source Type: research

Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermo-stability and yield
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00211C, Paperyuke cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng The catalytic activity is undoubtedly a key focus in enzyme engineering, whereas the complicated reaction conditions hindered some enzymes from industrialization, although they have a relative promising activity. This happened... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 16, 2024 Category: Molecular Biology Authors: yuke cen Source Type: research

Mutasynthesis Generates Nine New Pyrroindomycins
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00239C, PaperZhuhua Wu, Zhengxiang Xia, Zhijun Tang, Ji ’an Li, Wen Liu Pyrroindomycins (PYRs) represent the only spirotetramate natural products discovered in nature, which possess potent activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. Their unique structure and impressive biological activities... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 16, 2024 Category: Molecular Biology Authors: Zhuhua Wu Source Type: research

Identification of reaction sites and chlorinated products of purine bases and nucleosides during chlorination: a computational study
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB02111D, PaperFuhao Zhang, Yonghang Mo, Xiaomin Cao, Yingying Zhou, Yongdong Liu, ru-gang zhong Hypochlorous acid (HOCl) released from activated leukocytes plays a significant role in the human immune system, but also implicates in numerous diseases due to its inappropriate production. Chlorinated nucleobases induce... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 16, 2024 Category: Molecular Biology Authors: Fuhao Zhang Source Type: research

Selective synthesis of an elusive C-functionalized bis-cyclam through the bis-aminal route and study of its inhibition properties of CXCR4 chemokine receptor
This article presents the controlled synthesis of a rare example of C,C ’-linked bis-cyclam architecture in mild conditions through to the “bis-aminal” route, previously used for the advantageous synthesis of cyclam,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - March 16, 2024 Category: Molecular Biology Authors: Marie M Le Roy Source Type: research