Friedel –Crafts reactions for biomolecular chemistry
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Jun Ohata This review demonstrates advances in Friedel –Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Jun Ohata Source Type: research

Asymmetric total synthesis of humulane sesquiterpenoids alashanoids B, C, E, and F and 2,9-humuladien-6-ol-8-one
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00393D, PaperRasmita Barik, Samik Nanda Naturally occurring sesquiterpenes having humulane frameworks are structurally intriguing and possess significant biological profiles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Rasmita Barik Source Type: research

Catalyst- and base-free visible light-enabled radical relay trihalomethylation/functional group-migration/carbonylation with CX3SO2Cl
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00292J, PaperJinkai Hu, Chenglei Yang, Xiaotao Qin, Hui Liu, Tongtong Ma, Ao-tong Shi, Qing-Long Lv, Xingman Liu, Jinhui Yang, Dianjun Li A visible light-enabled photocatalyst-free radical trihalomethylation/cyano (or benzo[d]thiazol-2-yl) 1,4-migration/carbonylation reaction of 2-hydroxy-2-hex-5-enenitrile (or (benzo[d]thiazol-2-yl)-pent-4-enol) with CX3SO2Cl (X = F, Cl) is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and B...
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Jinkai Hu Source Type: research

Dess-Martin Periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Alexandra Serre, Vibhu Jha, Adele Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert Andrew Falconer Herein the first example of conversion of alcohols into carboxylic acids by use of the Dess-Martin Periodinane (DMP), which is otherwise routinely employed for the conversion to aldehydes, is reported.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Alexandra Serre Source Type: research

Total synthesis of diplofuranone A and diapolic acid A
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00433G, CommunicationDattatraya H. Dethe, Vimlesh Kumar, Nagabhushana C. Beeralingappa The first and concise syntheses of the anticancer agent diplofuranone A and the fatty acid-derived metabolite diapolic acid A have been demonstrated using easily accessible and commercially available starting materials. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Dattatraya H. Dethe Source Type: research

Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00338A, PaperAnil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera An efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Anil Kumar Saikia Source Type: research

Recent developments in the enzymatic modifications of steroid scaffolds
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Huibin Wang, Ikuro Abe Steroids are an important family of bioactive compounds. Steroid drugs are renowned for their multifaceted pharmacological activities and are the second-largest category in the global pharmaceutical market. Recent developments in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Huibin Wang Source Type: research

Design, Synthesis, and Biological Application of A-D-A Type Boranil Fluorescent Dyes
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00297K, PaperWei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song For the first time, three acceptor-donor-acceptor (A-D-A) type Boranil fluorescent dyes,CSU-BF-R (R = H, CH3, OCH3), featuring phenothiazine as the donor, were designed and synthesized.CSU-BF-R exhibited remarkable photophysical... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Wei Luo Source Type: research

The synthesis of alk-2-ynl Weinreb amides via Pd/Cu-catalysed oxidative carbonylation of terminal alkynes
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00290C, PaperBharati Mourya, Sandip T. Gadge, Bhalchandra M. Bhanage Synthesis of alk-2-ynl-Weinreb amidesvia Pd-catalyzed oxidative carbonylation of terminal alkynes andN,O-dimethylhydroxylamine hydrochloride at room temperature under low CO/O2 pressure is reported for the first time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Bharati Mourya Source Type: research

BBr3-Mediated Dearomatizative Spirocyclization of Biaryl Ynones: Facile Access to Spiro[5.5]dienones
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00274A, CommunicationGaurav Jaiswal, Subhas Chandra Pan BBr3 mediated dearomative spirocyclization of biaryl ynones has been reported. The direct synthesis of spiro[5.5]dienones with tri-substituted double bond is described for the first time in this paper. The scope... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Gaurav Jaiswal Source Type: research

Nickel-catalysed Regio- and Stereoselective Hydrocyanation of Alkynoates and Its Mechanistic Insights Proposed by DFT Calculations
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00380B, CommunicationShigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida We have developed a nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates that gives syn- -cyanoalkenes. DFT calculations suggest that a favored transition state promotes C-H bond formation for determining regio- and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Shigeru Arai Source Type: research

FeCl3-Catalyzed Three-Component Reaction for the Synthesis β-(1,2,3-Triazolyl)-Ketones by Using DMF as One Carbon Source
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00207E, CommunicationRuilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng Chen An FeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones (or acetophenones) and DMF (N,N-dimethylformamide) for the synthesis of β-(1,2,3-triazolyl)-ketones was developed. DMF serves as one carbon source, and the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 16, 2024 Category: Molecular Biology Authors: Ruilin Fang Source Type: research

Photoinduced decatungstate-catalyzed C(sp3) –H thioetherification by sulfinate salts
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00394B, PaperPengcheng Li, Jia-Lin Tu, Ao-Men Hu, Lin Guo, Chao Yang, Wujiong Xia A visible light photoinduced decatungstate-catalyzed C(sp3) –H thioetherification of hydrocarbons by sodium sulfite is herein reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 15, 2024 Category: Molecular Biology Authors: Pengcheng Li Source Type: research

HFIP-mediated C-3-alkylation of indoles and synthesis of indolo[2,3-b]quinolines & related natural products
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00414K, PaperAuqib Rashid, Waseem I. Lone, Preeti Dogra, Showkat Rashid, Bilal A. Bhat An expeditious metal free C-3 alkylation of indoles and its NIS-mediated deviation to indolo[2,3-b]quinolines is reported. Applications of these strategies in accessing bioactive natural products have also been demonstrated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 15, 2024 Category: Molecular Biology Authors: Auqib Rashid Source Type: research

A copper-catalyzed asymmetric Friedel –Crafts hydroxyalkylation of pyrazole-4,5-diones with 5-aminoisoxazoles
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00322E, CommunicationSiyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang An asymmetric Friede-Crafts hydroxyalkylation reaction was developed under the catalysis of chiral copper complexes. A variety of pyrazolone derivatives were obtained with excellent yields and enantioselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 15, 2024 Category: Molecular Biology Authors: Siyu Gao Source Type: research