Recent advances in the direct β-C(sp2)−H functionalization of enamides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02649E, Review ArticleTong-Hao Zhu, Shimin Xie, Pornchai Rojsitthisak, Jie Wu The direct β-C(sp2)−H functionalization of enamides has attracted increasing attention among the chemical community, due to the diverse biological and pharmaceutical activities of enamides. This review is focused on the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2020 Category: Molecular Biology Authors: Tong-Hao Zhu Source Type: research

Rhodium-catalyzed asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02536G, CommunicationJiaxin Yang, Xiuxiu Li, Cai You, Shuailong Li, Yu-Qing Guan, Hui Lv, Xumu Zhang A general and efficient approach for the synthesis of α-chiral cyclic lactones, lactams and ketones has been developedvia Rh-catalyzed asymmetric hydrogenation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2020 Category: Molecular Biology Authors: Jiaxin Yang Source Type: research

Lysosome-Targeted Near-infrared Fluorescent Probe for Imaging of Acid Phosphatase in Living Cells
We reported a lysosome-targeted near-infrared (NIR) fluorescent probe SHCy-P based... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 15, 2020 Category: Molecular Biology Authors: Xianshun Zeng Source Type: research

Synthesis of 2-arylamino-3-cyanoquinolines via a cascade reaction through a nitrilium intermediate
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02427A, PaperMani Ramanathan, Jing Wan, Yi-Hung Liu, Shie-Ming Peng, Shiuh-Tzung Liu A one-pot synthesis of 2-arylamino-3-cyanoquinolines was achieved by a cascade reaction of aryldiazonium tetrafluoroborate, 2-aminoarylketones and malononitrile. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Mani Ramanathan Source Type: research

Catalytic strategies towards 1,3-polyols synthesis by enantioselective cascades creating multiple alcohol functions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02675D, Review ArticleC éline Sperandio, Jean Rodriguez, Adrien Quintard This review highlights the different strategies ensuring enantioselective catalyst-controlled cascades, for the rapid preparation of 1,3-polyols or 1,3-polyols precursors. These cascades enable the selective assembly of multiple substrates considerably limiting... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: C éline Sperandio Source Type: research

Simple iodoalkyne-based organocatalysts for the activation of carbonyl compounds
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Juan V. Alegre-Requena, Alberto Valero-Tena, Isaac G. Sonsona, Santiago Uriel, Raquel P. Herrera A novel iodoalkyne-based organocatalyst is used to activate carbonyl compounds in the formation of bisindolylmethane derivatives and in the preparation of 3-(1H-indol-3-yl)-1-phenylbutan-1-one for the first time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Juan V. Alegre-Requena Source Type: research

Biomimetic total syntheses of baefrutones A –D, baeckenon B, and frutescones A, D–F
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02490E, PaperJi-Qin Hou, Jiang-Hong Yu, Heng Zhao, Ying-Ying Dong, QIu-Shi Peng, Bao-Bao Zhang, Hao Wang A biomimetic total syntheses of baefrutones A −D (1−4), baeckenon B (5), and frutescones A, D–F (6−9), isolated from the leaves of Baeckea frutescens, were achieved in 9, 8, and 5... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Ji-Qin Hou Source Type: research

Self-Assembling Quartets: How Do π-Conjugation Patterns Affect Resonance-Assisted Hydrogen Bonding?
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02412C, CommunicationHari Paudel, Ranjita Das, Chia-Hua Wu, Judy Wu Computed association strengths for 43 purine and pteridine quartets (38 to 100 kcal/mol) show excellent linear correlation with π-conjugation gain in the assembled monomers (r2 = 0.965). Even quartets having... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Hari Paudel Source Type: research

Chemical transformations of quaternary ammonium salts via C-N bond cleavage
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02667C, Review ArticleZhong-Xia Wang, Bo Yang Quaternary ammonium salts are readily prepared and show good reactivity in various organic transformations via C −N bond cleavage. In this review we summerize reactions of aryl, benzyl, allylic and propargyl... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Zhong-Xia Wang Source Type: research

Additive-free coupling of bromoalkynes with secondary phosphine oxides to generate alkynylphosphine oxides in acetic anhydride
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02750E, CommunicationHongjie Ruan, Ling-Guo Meng, Hailong Xu, Yuqing Liang, Lei Wang A coupling of bromoalkynes with secondary phosphine oxides was developed for the synthesis of alkynylphosphine oxides. This transformation was accomplished under additive-free conditions in acetic anhydride (Ac2O). The reaction could... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Hongjie Ruan Source Type: research

Recent Progress on the Total Synthesis of Marine Brominated Sesquiterpene Aplydactone
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02642H, Review ArticleRenzhi Chen, Sihan Yang, Yandong Zhang Aplydactone is a brominated sesquiterpene isolated from the sea hare Aplysia dactylomela. Structurally, it features a complex cage-like skeleton containing a highly strained tricyclic-[4.2.0.03,8]-4-decanone system. The unique structural features fascinate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Renzhi Chen Source Type: research

Recent Progresses in the Total Synthesis of Strychnos Alkaloids
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02627D, Review ArticleWeigang He, Pengyan Wang, Junhan Chen, Weiqing Xie The fascinating structure of strychnos alkaloids has evoked immense synthetic interests from chemical community since the landmark of Woodward ’s strychnine. After that, the pursuit of total synthesis of strychnos alkaloids... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Weigang He Source Type: research

Synthetic approaches towards avibactam and other diazabicyclooctane β-lactamase inhibitors
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02605C, Review ArticleLaure Peilleron, Kevin Cariou Avibactam is a non β-lactam β-lactamase inhibitor that has recently been approved in association with a β-lactam antibiotic for the treatment of severe infections caused by otherwise resistant bacteria. Its... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 14, 2020 Category: Molecular Biology Authors: Laure Peilleron Source Type: research

Facile synthesis of 2-alkynyl oxazoles via a Ce(OTf)3-catalyzed cascade reaction of alkynyl carboxylic acids with tert-butyl isocyanide
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02337B, CommunicationMing Cao, Qing-Hu Teng, Zhi-Wei Xi, Li-Qiu Liu, Ren-Yong Gu, Ying-Chun Wang We developed an efficient and novel protocol to synthesize 2-alkynyloxazoles fromtert-butyl isocyanide and alkynyl carboxylic acids, and these diversely functionalized oxazoles showed a certain degree of biological activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2020 Category: Molecular Biology Authors: Ming Cao Source Type: research

Br ønsted acid/visible-light-promoted Markovnikov hydroamination of vinylarenes with arylamines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02457C, PaperJiao Gui, Haisheng Xie, Fengjuan Chen, Zhipeng Liu, Xiaoqi Zhang, Fubin Jiang, Wei Zeng A Br ønsted acid/visible-light-promoted Markovnikov hydroamination of arylalkenes with arylamines in the presence of TPT and CF3CO2H has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2020 Category: Molecular Biology Authors: Jiao Gui Source Type: research

Visible-light-promoted radical cross-coupling of para-quinone methides with N-substituted anilines: An efficient approach to 2,2-diarylethylamines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02600B, CommunicationQiao-Lei Wu, Jing Guo, Gong-Bin Huang, Albert S. C. Chan, Jiang Weng, Gui Lu An efficient protocol to access 2,2-diarylethylamines via visible-light-promoted radical reactions of para-quinone methides (p-QMs) with N-alkyl anilines has been disclosed. The reactions featured metal-free, redox-neutral, mild reaction conditions, and wide... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2020 Category: Molecular Biology Authors: Qiao-Lei Wu Source Type: research

Chimeric γPNA-Invader probes: Using intercalator-functionalized oligonucleotides to enhance the DNA-targeting properties of γPNA
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02726B, PaperRaymond Emehiser, Patrick J. Hrdlicka Gamma peptide nucleic acids ( γPNAs), i.e., single-stranded PNA strands that are modified at the γ-position with (R)-diethylene glycol, and Invader probes, i.e., DNA duplexes with +1 interstrand zipper arrangements of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2020 Category: Molecular Biology Authors: Raymond Emehiser Source Type: research

Visible-Light-Mediated Photocatalytic Cross-Coupling of Acetenyl Ketones with Benzyl Trifluoroborate
In this report, we describe a simple visible light-triggered Barbier-type reaction by employing acetenyl ketones with benzyl trifluoroborates. Through a radical cross-coupling process, this photocatalytic protocol furnished a wide range... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2020 Category: Molecular Biology Authors: Jun Sun Source Type: research

Stereoselective synthesis of amino-substituted cyclopentafullerenes promoted by magnesium perchlorate/ferric perchlorate
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02248A, PaperWan Ma, Kun Wang, Cheng Huang, Hui-Juan Wang, Fa-Bao Li, Rui Sun, Li Liu, Chao-Yang Liu, Abdullah M. Asiri A reaction of [60]fullerene with cinnamaldehydes and amines promoted by magnesium perchlorate/ferric perchlorate stereoselectively afforded a series of novel amino-substituted cyclopentafullerenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2020 Category: Molecular Biology Authors: Wan Ma Source Type: research

Dimers formed with the mixed-type G-quadruplex binder pyridostatin specifically recognize human telomere G-quadruplex dimers
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02470K, PaperTian-Zhu Ma, Meng-Jia Zhang, Ting-Cong Liao, Jun-Hui Li, Min Zou, Zhou-Mo Wang, Chun-Qiong Zhou By adjusting the length of the polyether linkers, pyridostatin (PDS) dimers displayed higher binding selectivities and thermal stabilization towards human telomere antiparallel and mixed-type G-quadruplex dimers (G2T1). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2020 Category: Molecular Biology Authors: Tian-Zhu Ma Source Type: research

Substituent-controlled Chemoselective Synthesis of Multi-substituted Pyridones via One-pot Three-component Cascade Reaction
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02456E, PaperShitao Liu, Jisen Li, Junjie Lin, Fu-Jun Liu, Teng Liu, Chao Huang An efficient and concise one-pot strategy for the synthesis of multisubstituted pyridones via one-pot three-component cascade reaction catalyzed by Cs2CO3 under solvent-free conditions has been developed. The substituent-controlled chemoselective cycloaddition... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2020 Category: Molecular Biology Authors: Shitao Liu Source Type: research

Hypervalent iodine promoted ortho diversification: 2-aryl benzimidazole, quinazoline and imidazopyridine as directing templates
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02533B, PaperMoumita Saha, Asish R. Das (Diacetoxyiodo)benzene (PIDA) promoted Pd-catalyzed efficientortho C(sp2) –H acetoxylation, arylation, iodination and nitration are achieved using (NH)-free 2-substituted benzimidazole, quinazoline and imidazopyridine as chelating substrates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 10, 2020 Category: Molecular Biology Authors: Moumita Saha Source Type: research

Fluorinated alcohol mediated N,N ′-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02498K, PaperHongjin Shi, Lubin Xu, Didi Ren, Liang Wang, Weisi Guo, Shuai-Shuai Li Structurally diverse amino acids and their ester derivatives were convenientlyN,N′-dialkylatedvia TFE promoted cascade condensation/[1,5]-hydride transfer/cyclization for straightforward construction of tetrahydroquinazolines incorporating various amino acids. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 9, 2020 Category: Molecular Biology Authors: Hongjin Shi Source Type: research

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Lujuan Xu, Marco Raabe, Maksymilian Marek Zegota, Joao Nogueira, Vijay Chudasama, Seah Ling Kuan, Tanja Weil The inverse electron demand Diels-Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise in protein modification and manipulation. Herein, we report the design and synthesis of a tetrazine-based disulfide... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 9, 2020 Category: Molecular Biology Authors: Lujuan Xu Source Type: research

Photo-induced glycosylation using a diaryldisulfide as an organo-Lewis photoacid catalyst
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02674F, CommunicationNaoto Iibuchi, Takahiro Eto, Manabu Aoyagi, Reiji Kurinami, Hayato Sakai, Taku Hasobe, Daisuke Takahashi, Kazunobu Toshima Photo-induced glycosylations of several acceptors with trichloroacetimidate donors using bis(2-naphtyl)disulfide as an organo-Lewis photoacid (LPA) catalyst proceeded effectively to give the corresponding glycosides in good to high yields. In addition,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 9, 2020 Category: Molecular Biology Authors: Naoto Iibuchi Source Type: research

Photeroids A and B, unique phenol –sesquiterpene meroterpenoids from the deep-sea-derived fungus Phomopsis tersa
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02625H, CommunicationShanchong Chen, Zhaoming Liu, Haibo Tan, Yuchan Chen, Shuang Zhu, Hongxin Liu, Weimin Zhang Photeroids A (1) and B (2), two structurally fascinating meroterpenoids, were isolated from the deep-sea-derived fungusPhomopsis tersa FS441. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 9, 2020 Category: Molecular Biology Authors: Shanchong Chen Source Type: research

Looking at the big picture in ASM/EDA analysis: the case of the ortho-para regioselectivity rule in Diels-Alder reactions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02671A, PaperNicol ás Grimblat, Ariel Marcelo Sarotti The regioselectivity of the Diels-Alder reaction is predicted by the ortho-para rule which has been explained from FMO theory. Using DFT calculations, the activation-strain model and energy decomposition analysis we... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 9, 2020 Category: Molecular Biology Authors: Nicol ás Grimblat Source Type: research

Cucurbit[7]uril-driven modulation of ligand –DNA interactions by ternary assembly
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02543J, PaperEkaterina Y. Chernikova, Anna Y. Ruleva, Vladimir B. Tsvetkov, Yuri V. Fedorov, Valentin V. Novikov, Tseimur M. Aliyeu, Alexander A. Pavlov, Nikolay E. Shepel, Olga A. Fedorova Cucurbit[7]uril induces a change in the ligand –DNA binding mode and destroys dye aggregates templated by DNA through the formation of a ternary complex. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2020 Category: Molecular Biology Authors: Ekaterina Y. Chernikova Source Type: research

An effective reagent to functionalize alcohols with phosphocholine
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02582K, PaperLianyan L. Xu, Lawrence J. Berg, D. Jamin Keith, Steven D. Townsend A one-pot, three-step sequence has been developed to synthesize phosphocholine derivatives. The method has been applied to the synthesis of several biologics such as the anti-parasitic drug miltefosine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2020 Category: Molecular Biology Authors: Lianyan L. Xu Source Type: research

Self-assembly of amphiphilic aryl-squaramides in water driven by dipolar π–π interactions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02085C, PaperSergi Bujosa, Eduardo Castellanos, Antonio Frontera, Carmen Rotger, Antonio Costa, Bartolome Soberats Amphiphilic aryl-squaramides self-assemblevia unprecedented dipolar π–π interactions forming well-defined supramolecular aggregates and self-consistent hydrogels in water To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2020 Category: Molecular Biology Authors: Sergi Bujosa Source Type: research

Recent trends in catalytic sp3 C –H functionalization of heterocycles
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Milanpreet Kaur, Jeffrey F. Van Humbeck In this mini-review, we attempt to highlight gaps in existing techniques for sp3 C –H activation adjacent to heterocycles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2020 Category: Molecular Biology Authors: Milanpreet Kaur Source Type: research

Solid-phase synthesis of branched oligonucleotides containing the biologically relevant dCyd341 interstrand crosslink DNA lesion
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB01021A, PaperMarisa TAVERNA PORRO, Christine Saint-Pierre, Didier Gasparutto, Jean-Luc Ravanat Branched oligonucleotides containing a biological relevant DNA lesion, dCyd341 that involves an interstrand crosslink between a cytosine base on one strand and a ribose moiety of the opposite strand, was... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2020 Category: Molecular Biology Authors: Marisa TAVERNA PORRO Source Type: research

Probing the helical integrity of multivicinal all-syn-fluoro alkanes
This study extends our interest in the synthesis and conformational behaviour of all-syn multivicinal fluoro alkane motifs. Specifically an all-syn 1,2,3,6,7,8-hexafluorooctane chain was assembled with a run of three fluorines,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2020 Category: Molecular Biology Authors: Nawaf Al-Maharik Source Type: research

Recent applications of chiral phosphoric acids in palladium catalysis
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02205H, Review ArticleVan T. Tran, Sri Krishna Nimmagadda, Mingyu Liu, Keary M. Engle A variety of catalytic asymmetric reactions have been realized during the past decade through the combined action of palladium and chiral phosphoric acids (CPAs). This review surveys key examples and examines the underlying mechanisms of stereoinduction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 7, 2020 Category: Molecular Biology Authors: Van T. Tran Source Type: research

Ag-Catalyzed minisci C –H difluoromethylarylation of N-heteroarenes
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02586C, CommunicationXiaojuan Xie, Yifang Zhang, Jian Hao, Wen Wan A mild silver-catalyzed decarboxylative C –H difluoromethylarylation of electron-deficient N-heteroarenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 7, 2020 Category: Molecular Biology Authors: Xiaojuan Xie Source Type: research

Cerium photocatalyzed dehydrogenative lactonization of 2 ‑arylbenzoic acids
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02676B, PaperKetan Wadekar, Suraj aswale, Veera Reddy Yatham The first cerium photocatalyzed dehydrogenative lactonization of 2-arylbenzoic acids has been developed. This operationally simple protocol allow rapid access to synthetically useful coumarins on a gram scale by employing CeCl3... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 7, 2020 Category: Molecular Biology Authors: Ketan Wadekar Source Type: research

Total synthesis of exigurin: the Ugi reaction in a hypothetical biosynthesis of natural products
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02249J, PaperSeijiro Hosokawa, Keisuke Nakanishi, Yutaro Udagawa, Mitsutoshi Maeda, Seiya Sato, Keiji Nakano, Toshiya Masuda, Yoshiyasu Ichikawa Bioinspired U-5C-4CR employing ( −)-10-epi-axisonitrile-3, formaldehyde and sarcosine in methanol showed remarkable efficiency to assemble multicomponents in a one-pot process, leading to the first total synthesis of exigurin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 6, 2020 Category: Molecular Biology Authors: Seijiro Hosokawa Source Type: research

Complexation of 5-aminovaleric acid zwitterions in aqueous/methanol solution by heterotopic tri-cationic receptors
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02234A, PaperWojciech Walczak, Maciej Zakrzewski, Grzegorz Cichowicz, Piotr Pi ątek Heterotopic tri-cationic receptor based on 4,10,16-triaza-18-crown-6 is capable of efficient and selective binding of the zwitterionic form of 5-aminovaleric acid (5-AVA) in aqueous/methanol solution. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 6, 2020 Category: Molecular Biology Authors: Wojciech Walczak Source Type: research

Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB01190K, PaperDavid Goyard, B álint Kónya, Katalin Czifrák, Paolo Larini, Fanny Demontrond, Jeremy Leroy, Sophie Balzarin, Michel Tournier, Didier Tousch, Pierre Petit, Cedric Duret, Patrick Maurel, Tibor Docsa, Pal Gergely, László Somsák, jean-pierre praly, Jacqueline Azay-Milhau, Sebastien Vidal The design of glycogen phosphorylase (GP) inhibitors targeting the catalytic site of the enzyme is a promising strategy for a better control of hyperglycaemia in the context of type 2... The content of this RSS Feed (c) The Roy...
Source: RSC - Organic and Biomolecular Chemistry - January 6, 2020 Category: Molecular Biology Authors: David Goyard Source Type: research

Hypersensitive azobenzenes: facile synthesis of clickable and cleavable azo linkers with tunable and high reducibility
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02515D, CommunicationTaejun Eom, Anzar Khan Molecular design principles of azobenzene nuclei that can be cleaved in a few seconds under mild reducing conditions are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 6, 2020 Category: Molecular Biology Authors: Taejun Eom Source Type: research

Thiophene-linked tetramethylbodipy-labeled nucleotide for viscosity-sensitive oligonucleotide probes of hybridization and protein-DNA interactions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02634G, PaperPedro Guixens-Gallardo, Jana Humpolickova, Paul Sebastian Miclea, Radek Pohl, Tomas Kraus, Piotr Jurkiewicz, Martin Hof, Michal Hocek Cytosine 2'-deoxyribonucleoside dCTBdp and its triphosphate (dCTBdpTP) bearing tetramethylated thiophene-bodipy fluorophore attached at position 5 were designed and synthesized. The green fluorescent nucleoside dCTBdp showed a perfect dependence of fluorescence... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 3, 2020 Category: Molecular Biology Authors: Pedro Guixens-Gallardo Source Type: research

Synthesis of 2-Arylamino-3-cyanoquinolines via A Cascade Reaction Through Nitrilium Intermediate
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02427A, PaperMani Ramanathan, Jing Wan, Yi-Hung Liu, Shie-Ming Peng, Shiuh-Tzung Liu A new method for the preparation of 2-amino-3-cyanoquinolines from readily available aryldiazonium salts, 2-aminoarylketones and malononitrile via a cascade reaction is reported. This one-pot appraoch involves in situ generation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 3, 2020 Category: Molecular Biology Authors: Mani Ramanathan Source Type: research

Synthesis and chiroptical properties of cylindrical macrocycles comprising two calix[3]aramide moieties
Org. Biomol. Chem., 2020,18,230-236 DOI: 10.1039/C9OB02022E, PaperYuuki Saito, Misa Satake, Ryuichi Mori, Misaki Okayasu, Hyuma Masu, Masahide Tominaga, Kosuke Katagiri, Kentaro Yamaguchi, Shoko Kikkawa, Hidemasa Hikawa, Isao Azumaya Novel chiral macrocyclic aromatic amides of medium molecular weight were synthesized by the one-step amide coupling of a bis(alkylamino)terphenyl diacid as monomer. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Yuuki Saito Source Type: research

Switching of regioselectivity in base-mediated diastereoselective annulation of 2,3-epoxy tosylates and their N-tosylaziridine analogs with 2-mercaptobenzimidazole
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02454A, PaperArup Jyoti Das, Hemi Borgohain, Bipul Sarma, Sajal Kumar Das Benzimidazole-based tricyclic compounds have been synthesizedvia base-mediated diastereoselective cyclization of 2,3-epoxy tosylates and theirN-tosylaziridine analogs with 2-mercaptobenzimidazole. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Arup Jyoti Das Source Type: research

K2S2O8-HFIP synergistically promoted para-selective sp3 C –H bond diarylation of glycine esters
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02489A, PaperQingfeng Xu, Bang Li, Yujie Ma, Fei Sun, Yanan Gao, Na Ye A metal-free K2S2O8-HFIP synergistically promoted Friedel –Crafts dialkylation between a glycine derivative andN-substituted aniline was developed to efficiently synthesize diarylmethane derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Qingfeng Xu Source Type: research

Iron-catalyzed [3 + 2]-cycloaddition of in situ generated N-ylides with alkynes or olefins: access to multi-substituted/polycyclic pyrrole derivatives
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02571E, CommunicationKai Zhou, Ming Bao, Jingjing Huang, Zhenghui Kang, Xinfang Xu, Wenhao Hu, Yu Qian An iron-catalyzed three-component reaction of benzimidazoles with diazoacetates and electron-deficient alkynes or alkenes that delivers multi-substituted pyrroles, pyrrolo[1,2-a]benzimidazoles and pyrrolo[1,2-a] quinoxalinones has been reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Kai Zhou Source Type: research

Isoquinolinequinone N-oxides as anticancer agents effective against drug resistant cell lines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02441G, PaperRyan D. Kruschel, Alyah Buzid, Udaya B. Rao Khandavilli, Simon E. Lawrence, Jeremy D. Glennon, Florence O. McCarthy 6- and 7-Substituted isoquinolineN-oxides are identified as redox active, adduct forming, anticancer agents and effective against drug resistant cell lines at nanomolar concentrations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Ryan D. Kruschel Source Type: research

Self-assembly in water of amphiphilic aryl-squaramides driven by dipolar π-π interactions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02085C, PaperSergi Bujosa, Eduardo Castellanos, Antonio Frontera, Carmen Rotger, Antonio Costa, Bartolome Soberats Squaramides are versatile compounds with a great capacity to interact via non-covalent interactions and therefore of interest for the development of supramolecular systems and functional materials. In the present work,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Sergi Bujosa Source Type: research

Fluorinated Alcohol Mediated N,N ’-Dialkylation of Amino Acids via Cascade [1,5]-Hydride Transfer/Cyclization for Concise Synthesis of Tetrahydroquinazoline
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02498K, PaperHongjin Shi, Lubin Xu, Didi Ren, Liang Wang, Weisi Guo, Shuai-Shuai Li Structurally diverse amino acids and their ester derivatives were conveniently N,N ’-dialkylated via a TFE-promoted cascade condensation/[1,5]-hydride transfer/cyclization for straightforward construction of pharmeutically significant tetrahydroquinazolines incorporating various amino acids, which featured... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Hongjin Shi Source Type: research

Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02546D, Review ArticleSatsawat Visansirikul, Stephen A. Kolodziej, Alexei V Demchenko The S. aureus bacterium is surrounded by capsular polysaccharides. These capsular polysaccharides are important in the pathogenesis of staphylococcal infection. The majority strains express capsular polysaccharides type 5 (CP5) or... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 2, 2020 Category: Molecular Biology Authors: Satsawat Visansirikul Source Type: research