Visible light photoredox catalyzed deprotection of 1,3-oxathiolanes
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02517K, PaperMingyang Yang, Zhimin Xing, Bowen Fang, Xingang Xie, Xuegong She An efficient visible light photoredox catalyzed aerobic deprotection of 1,3-oxathiolanes using organic dye Eosin Y as the photocatalyst was disclosed. The deprotection procedure features the use of metal-free catalyst, mild... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 6, 2019 Category: Molecular Biology Authors: Mingyang Yang Source Type: research

Lewis or Br ønsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02211B, PaperHao-Zhao Wei, Liu-Zhu Yu, Min Shi We developed a facile synthetic method to access the cyclopenta[b]naphthalene skeleton from Lewis or Br ønsted acid-catalysed propargylic alcohol-tethered alkylidenecyclopropanes with indole and pyrrole derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Hao-Zhao Wei Source Type: research

Stereoselective synthesis of hydrazinodihydrofurans via cascade Michael addition –substitution involving the reaction of curcumin and other β-dicarbonyls with α-hydrazinonitroalkenes
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB01974J, PaperKalisankar Bera, Narasimham Ayyagari, Nishikant Satam, Irishi N. N. Namboothiri Reaction of 1,3-dicarbonyls with α-hydrazinonitroalkenes leads to 2-hydrazino-2,3-dihydrofurans with high stereoselectivity in the presence of atert-leucine derived squaramide and K2CO3 in aqueous THF. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Kalisankar Bera Source Type: research

BF3 ·OEt2-promoted tandem Meinwald rearrangement and nucleophilic substitution of oxiranecarbonitriles
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02428J, PaperChuangchuang Xu, Jiaxi Xu Introducing a cyano leaving group into epoxides results in BF3·OEt2-promoted tandem Meinwald rearrangement and nucleophilic substitution to synthesize arylacetic derivatives from vicinal arylcyanoepoxides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Chuangchuang Xu Source Type: research

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02002K, PaperFr édéric Lassagne, Camille Duguépéroux, Carlos Roca, Concepcion Perez, Ana Martinez, Blandine Baratte, Thomas Robert, Sandrine Ruchaud, Stéphane Bach, William Erb, Thierry Roisnel, Florence Mongin New potent inhibitors of protein kinase GSK3 α were synthesized from 6-amino-3-chloroquinoxaline. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Fr édéric Lassagne Source Type: research

A hybrid polymer to target blood group dependence of cholera toxin
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Diksha Haksar, Linda Quarles van Ufford, Roland J. Pieters New hybrid glycopolymers were synthesized that contain two epitopes blocking GM1- and fucose-based intoxication modes of the cholera toxin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Diksha Haksar Source Type: research

Fast Construction of Isoquinolin-1(2H)-ones by Direct Intramolecular C-H/N-H Functionalization under Metal-Free Conditions
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02430A, CommunicationLi-Rong Wen, Guang-Yi Ren, Rui-Sen Geng, Lin-Bao Zhang, Ming Li The general protocol for the synthesis of isoxazolidine-fused isoquinolin-1(2H)-ones was established with the assist of bench stable hypervalent iodine reagent PIDA. The polycyclic six-, seven- and eight-membered N-heterocycles can be... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Li-Rong Wen Source Type: research

Branched lipid chains to prepare cationic amphiphiles producing hexagonal aggregates: supramolecular behavior and application to gene delivery
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02381J, PaperAmal Bouraoui, Rosy Ghanem, Mathieu Berchel, Laure Deschamps, V éronique Vié, Gilles Paboeuf, Tony Le Gall, Tristan Montier, Paul-Alain jaffrès A ramified lipid alcohol, 2-hexyldecanol, was used as hydrophobic moiety to prepare at a gram scale in 3 to 4 steps, cationic amphiphiles featuring either a trimethylammonium 5, dimethylhydroxyethylammonium 6... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Amal Bouraoui Source Type: research

Recent progress on transition-metal-catalyzed hydrocyanation of nonpolar alkenes and alkynes
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02374G, Review ArticleHongru Zhang, Xin Su, Kaiwu Dong Hydrocyanation is a powerful method for the preparation of polymer monomers and biologically interesting moieties including nitriles, amines, acids and amides. This review summarized the researches on transition-metal-catalyzed (asymmetric) hydrocyanation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 5, 2019 Category: Molecular Biology Authors: Hongru Zhang Source Type: research

The impact of cation structure upon the acidity of triazolium salts in dimethyl sulfoxide
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02258A, PaperNicholas Konstandaras, Michelle H. Dunn, Max S. Guerry, Christopher D. Barnett, Marcus L. Cole, Jason B. Harper The effect of structure on the pKa value of triazolium salts in dimethyl sulfoxide is quantified, considering common structural and electronic motifs. Included is the first pKa measurement of a triazolium salt that generates a mesionic carbene. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Nicholas Konstandaras Source Type: research

Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT)
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02296A, CommunicationKangping Xu, Can Yang, Yuanyuan Xu, Dan Li, Shumin Bao, Zhenxing Zou, Fenghua Kang, Guishan Tan, Shu-Ming Li, Xia Yu Regio-selective geranylation of natural biflavonoids usingAspergillus terreus aromatic prenyltransferase (AtaPT) as an efficient catalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Kangping Xu Source Type: research

Heavy-atom-free BODIPY photosensitizers with intersystem crossing mediated by intramolecular photoinduced electron transfer
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02170A, Review ArticleMikhail A. Filatov This review discusses photoinduced electron transfer, triplet state formation from charge transfer states and singlet oxygen generation by heavy-atom-free BODIPY donor –acceptor dyads and dimers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Mikhail A. Filatov Source Type: research

One-step assembly of alkoxypyrroloindolines via iodine-catalyzed alkoxycyclization of indole derivatives
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02287B, CommunicationYan Li, Juan Guo, Xunbo Lu, Fangrui Zhong Herein we report an iodine-catalyzed alkoxycyclization of tryptamine derivatives under mild reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Yan Li Source Type: research

Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02334H, PaperChun-Xue Yu, Ru-Yue Wang, Feng-Ming Qi, Pan-Jie Su, Yi-Fan Yu, Bing Li, Ye Zhao, De-Juan Zhi, Zhan-Xin Zhang, Dong-Qing Fei Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated fromEuphorbia pulcherrima. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Chun-Xue Yu Source Type: research

Stereochemistry, lipid length and branching influences Mincle agonist activity of monoacylglycerides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02302J, PaperAyesha Khan, Chriselle D. Braganza, Kristel Kodar, Mattie S. M. Timmer, Bridget L. Stocker Structure activity relationship of Monoacylglycerides shows enhanced Mincle agonist activity of ligands withsn-1 stereochemistry and long-lipid chains through IL-8 production in human peripheral blood monocytes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Ayesha Khan Source Type: research

Phosphotyrosine isosteres: past, present and future
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB01998G, Review ArticleRobert A. Cerulli, Joshua A. Kritzer In this Review, Cerulli and Kritzer describe the past, present, and future potential of medicinal chemistry approaches to mimicking phosphotyrosine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Robert A. Cerulli Source Type: research

Photoaffinity probes for nematode pheromone receptor identification
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02099C, CommunicationYing K. Zhang, Douglas K. Reilly, Jingfang Yu, Jagan Srinivasan, Frank C. Schroeder Identification of pheromone receptors plays a central role for uncovering signaling pathways that underlie chemical communication in animals. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Ying K. Zhang Source Type: research

Design, synthesis and cytotoxicity of novel hexacyclic saframycin –ecteinascidin analogs
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02426C, PaperXiangran Lu, Xuan Pan, Baohe Guan, Zhanzhu Liu Two series of novel tetrahydroisoquinoline –tetrahydrocarboline hybrid derivatives were prepared and their cytotoxicities were tested. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Xiangran Lu Source Type: research

Synthesis of lactone-fused pyrroles by ruthenium-catalyzed 1,2-carbon migration-cycloisomerization
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Takuma Watanabe, Yuichiro Mutoh, Shinichi Saito Synthesis of lactone-fused pyrroles including pharmaceutically important Ningalin B derivatives has been achieved by ruthenium-catalyzed 1,2-carbon migration/cyclization reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Takuma Watanabe Source Type: research

Developments in the construction of cyclopropanols
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02197C, Review ArticleQiang Liu, Bingxin You, Guanqun Xie, Xiaoxia Wang This review introduces and discusses the advances in the construction of cyclopropanols; improved synthetic methods are included, as well as the highly stereoselective production of cyclopropanols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Qiang Liu Source Type: research

Reversible control of RNA interference by siRNAzos
In this study, we report the reversible control of RNA interference using siRNAzos, a class of siRNAs that contain azobenzene. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Matthew L. Hammill Source Type: research

Synthesis of substituted 2-alkylquinolines by visible-light photoredox catalysis
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02259G, PaperYousheng Mei, Jie Liu, Lei Wang, Pinhua Li A simple and efficient protocol for the synthesis of substituted 2-alkylquinoline scaffolds was developed by employing visible-light photoredox catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Yousheng Mei Source Type: research

A minimalistic hydrolase based on co-assembled cyclic dipeptides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02198A, PaperAlexander J. Kleinsmann, Boris J. Nachtsheim Cyclic dipeptides based on proteinogenic amino acids form higher aggregates in water with an enzyme-like activity. Are they relevant for abiogenesis? To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Alexander J. Kleinsmann Source Type: research

Metal-free late-stage C(sp2) –H functionalization of N-aryl amines with various sodium salts
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02217A, PaperChandrashekar Mudithanapelli, Mi-hyun Kim Metal-free consecutive C(sp2) –X (X = Cl, Br, S, N) bond formations ofN-aryl amines (cyclic, fused, carbamate, and aminium radicals) were achieved under mild conditions using PIFA and simple nonharmful sodium salts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Chandrashekar Mudithanapelli Source Type: research

The first total synthesis of rebaudioside R
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02422K, PaperGuo-En Wen, Zhi Qiao, Hui Liu, Zhi-Yong Zeng, Yuan-Hong Tu, Jian-Hui Xia, Qing-Ju Zhang, Jian-Song Sun The first total synthesis of rebaudioside R has been achievedvia two different approaches. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Guo-En Wen Source Type: research

The effect of spermidine on guanine decomposition via photoinduced electron transfer in DNA
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB01860C, CommunicationMayu Esumi, Shunsuke Sakurai, Makiko Tanaka The addition of spermidine caused the attenuation of guanine decompositionvia photoinduced electron transfer in pyrene-modified DNA, and higher added concentrations of spermidine resulted in the promotion of decomposition in condensed DNA. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Mayu Esumi Source Type: research

Design, synthesis, and evaluation of azo D –π-A dyes as photothermal agents
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02066G, PaperShinichiro Fuse, Tsukasa Oishi, Keisuke Matsumura, Yoshihiro Hayashi, Susumu Kawauchi, Hiroyuki Nakamura Thirteen readily accessible azo D –π-A dyes, intended for use as photothermal agents, were synthesized using only a few steps. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Shinichiro Fuse Source Type: research

Effect of n-alkyl substitution on Cu(II)-selective chemosensing of Rhodamine-B derivatives
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02439E, PaperSantosh Kumar Mishra, Suryakanta Dehuri, Bamaprasad Bag A series of rhodamine-B hydrazide based molecular probes (1-10) were synthesized by their derivatization with n-alkyl chains of different lengths at hydrazide amino- end. These probes exhibited absorption (A~557) and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Santosh Kumar Mishra Source Type: research

A Synthetic Route to 1,4-Disubstituted Tetrahydro- β-carbolines and Tetrahydropyranoindoles via Ring-Opening/Pictet-Spengler Reaction of Aziridines and Epoxides with Indoles/Aldehydes
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02098E, PaperImtiyaz Ahmad Wani, Gaurav Goswami, Sahid Sk, Abhijit Mal, Masthanvali Sayyad, Manas K. Ghorai A simple and efficient synthetic route to various 1,4-disubstituted tetrahydro- β-carbolines and tetrahydropyrano[3,4-b]indoles in high yields and stereoselectivity via LiClO4-catalyzed SN2-type ring opening of aziridines and epoxides with indoles followed by... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Imtiyaz Ahmad Wani Source Type: research

Probing the Determinants of Porosity in Protein Frameworks: Co-crystals of Cytochrome c and an Octa-anionic Calix[4]arene
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02275A, CommunicationJimi M. Alex, Giovanna Brancatelli, Stefano Volpi, Carmela Bonaccorso, Alessandro Casnati, Silvano Geremia, Peter B. Crowley Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. Two crystal structures of an octa-ionic calix[4]arene (sclx4mc) in complex with yeast or horse heart cytochrome c (cytc) are reported.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Jimi M. Alex Source Type: research

Recent Applications of Chiral Phosphoric Acids in Palladium Catalysis
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02205H, Review ArticleVan T Tran, Sri Krishna Nimmagadda, Mingyu Liu, Keary M. Engle Through the combined action of palladium catalysts and chiral phosphoric acids (CPAs) a variety of catalytic asymmetric reactions have been realized during the past decade, including allylation, alkene functionalization, and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Van T Tran Source Type: research

2-Substituted 2'-Deoxyinosine 5'-Triphosphates as Substrates for Polymerase Synthesis of Minor-Groove-Modified DNA and Effects on Restriction Endonuclease Cleavage
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02502B, PaperJan Matyasovsky, Michal Hocek Five 2-substituted 2'-deoxyinosine triphosphates (dRITP) were synthesized and tested as substrates in enzymatic synthesis of minor-groove base-modified DNA. Only 2-methyl and 2-vinyl derivatives proved to be good substrates for Therminator... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Jan Matyasovsky Source Type: research

Base-mediated intramolecular one-pot double-cyclization of epoxide-tethered 2-fluorobenzenesulfonamides: an avenue to 1,4-benzoxazine-fused benzothiaoxazepine-1,1-dioxides
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02377A, CommunicationJonali Das, Biraj Jyoti Borah, Sajal Kumar Das Herein, we describe the synthesis of hitherto unknown 1,4-benzoxazine-fused benzothiaoxazepine-1,1-dioxides by a NaH-promoted intramolecular one-pot double-cyclization of epoxide-tethered 2-fluorobenzene sulfonamides. Mechanistically, the reactions proceed via an intramolecular epoxide ring-opening followed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 4, 2019 Category: Molecular Biology Authors: Jonali Das Source Type: research

Developments in the construction of cyclopropanols
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02197C, Review ArticleQiang Liu, Bingxin You, Guanqun Xie, Xiaoxia Wang This review introduces and discusses the advances in the construction of cyclopropanols; improved synthetic methods are included, as well as the highly stereoselective production of cyclopropanols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 3, 2019 Category: Molecular Biology Authors: Qiang Liu Source Type: research

Visible-light-induced intramolecular radical cascade of α-bromo-N-benzyl-alkylamides: a new strategy to synthesize tetracyclic N‑fused indolo[2,1-a]isoquinolin-6(5H)-ones
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02294E, PaperXiaoshuang Gao, Chengyang Li, Yao Yuan, Xiaomin Xie, Zhaoguo Zhang Polycyclic indole scaffolds are ubiquitous in pharmaceuticals, natural products and materials science. Here in, we present a visible-light-initiated intramolecular aryl migration/desulfonylation/cyclization cascade reaction for the synthesis of tetracyclic indolo[2,1-a]isoquinolin-6(5H)-ones. This... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 3, 2019 Category: Molecular Biology Authors: Xiaoshuang Gao Source Type: research

Diastereoselective construction of carbazole-based spirooxindoles via Levy three-component Reaction
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02013F, PaperShao-Cong Zhan, Jing Sun, Ruzhang Liu, Chaoguo Yan The CuSO4 catalyzed three-component reaction of indole-2-acetate, aromatic aldehydes and 3-methyleneoxindoles in toluene at 130 oC afforded polysubstituted spiro[carbazole-3,3'-indolines] in good yields with high diastereoselectivity. When isatylidene malononitriles were used... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 2, 2019 Category: Molecular Biology Authors: Shao-Cong Zhan Source Type: research

Water-DMSO-promoted one-pot synthesis of two new series of dihydropyrrolo[2,3-h]quinolines
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02342A, CommunicationHui Liao, Qiuhua Zhu Pyrrolo[2,3-h]quinolines are important heterocycles with various biological activities. Here, two new series of dihydropyrrolo[2,3-h]quinolines with more substituents on quinoline ring (4 and6) were efficiently synthesizedvia the catalyst-free three-component... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 2, 2019 Category: Molecular Biology Authors: Hui Liao Source Type: research

The reticent tautomer: Exploiting the interesting multisite and multitype reactivity of 4-pyrrolin-2-ones.
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Tamsyn Montagnon, Dimitris Kalaitzakis, Manolis Sofiadis, Georgios Vassilikogiannakis 4-Pyrrolin-2-ones are a lesser known tautomeric relative of the 3-pyrrolin-2-ones. Despite their infrequent appearance in the literature, they are very interesting and useful compounds. They have highly controllable, multisite and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 1, 2019 Category: Molecular Biology Authors: Tamsyn Montagnon Source Type: research

A trimethyllysine-containing trityl tag for solubilizing hydrophobic peptides
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02253H, PaperShun Masuda, Shugo Tsuda, Taku Yoshiya AnNε-Tri-Me-Lys-containing solubilizing tag proved superior to that containing Lys/Arg/Glu/Cys-sulfonate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 29, 2019 Category: Molecular Biology Authors: Shun Masuda Source Type: research

Design, synthesis and cytotoxicity of novel hexacyclic saframycin –ecteinascidin analogs
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02426C, PaperXiangran Lu, Xuan Pan, Baohe Guan, Zhanzhu Liu Two series of novel tetrahydroisoquinoline –tetrahydrocarboline hybrid derivatives were prepared and their cytotoxicities were tested. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 29, 2019 Category: Molecular Biology Authors: Xiangran Lu Source Type: research

A hybrid polymer to target blood group dependence of cholera toxin
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Diksha Haksar, Linda Quarles van Ufford, Roland Pieters Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 28, 2019 Category: Molecular Biology Authors: Diksha Haksar Source Type: research

Peroxide-mediated site-specific C-H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free condition
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02328C, CommunicationShengzhou Jin, Hua Yao, Sen Lin, XIaoqing You, Yao Yang, Zhaohua Yan An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free condition is described. In this protocol, peroxides serve as both the radical initiator and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 28, 2019 Category: Molecular Biology Authors: Shengzhou Jin Source Type: research

Metal free biomimetic deaminative direct C –C coupling of unprotected primary amines with active methylene compounds
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02163A, CommunicationSantanu Ghosh, Chandan K. Jana An unprecedented direct C –C coupling reaction of unprotected primary amines with active methylene compounds is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 28, 2019 Category: Molecular Biology Authors: Santanu Ghosh Source Type: research

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02002K, Paperfrederic LASSAGNE, Camille Dugu épéroux, Carlos Roca, Concepción Pérez, Ana Martinez, Blandine Baratte, Thomas Robert, Sandrine Ruchaud, Stéphane Bach, William Erb, Thierry Roisnel, Florence MONGIN 2,7-Disubstituted oxazolo[5,4-f]quinoxalines were synthesized from 6-amino-2-chloroquinoxaline in four steps (iodination at C5, substitution of the chloro group, amidation and copper-catalysed cyclization) and 28 to 44% overall yields. 2,8-Disubstituted oxazolo[5,4-f]quinoxalines can... The content of this RSS Feed (c) ...
Source: RSC - Organic and Biomolecular Chemistry - November 28, 2019 Category: Molecular Biology Authors: frederic LASSAGNE Source Type: research

The First Total Synthesis of Rebaudioside R
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02422K, PaperGuo-En Wen, Zhi Qiao, Hui Liu, Zhiyong Zeng, Yuan-Hong Tu, Jianhui Xia, Qing-Ju Zhang, Jian-Song Sun With easily available monosaccharides as well as steviol as starting materials, the first total synthesis of rebaudioside R with a xylosyl core in the C13-OH linked sugar chain was accomplished... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 28, 2019 Category: Molecular Biology Authors: Guo-En Wen Source Type: research

Effect of spermidine on guanine decomposition via photoinduced electron transfer in DNA
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01860C, CommunicationMayu Esumi, Shunsuke Sakurai, Makiko Tanaka Spermidine, a trivalent organic cation, induced DNA structural changes and suppressed guanine photooxidative decomposition via electron transfer though pyrene-modified DNA. On the other hand, adding higher concentrations of spermidine resulted... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 28, 2019 Category: Molecular Biology Authors: Mayu Esumi Source Type: research

The visible-light-triggered regioselective alkylation of quinoxalin-2(1H)-ones via decarboxylation coupling
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02203A, PaperHongdou Zhang, Jun Xu, Min Zhou, Jianming Zhao, Pengfei Zhang, Wanmei Li An efficient protocol to synthesize 3-alkylated quinoxalin-2(1H)-ones through photocatalytic decarboxylation coupling reactions of quinoxalin-2(1H)-ones withN-hydroxyphthalimide ester was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 27, 2019 Category: Molecular Biology Authors: Hongdou Zhang Source Type: research

Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02334H, PaperChun-Xue Yu, Ru-Yue Wang, Feng-Ming Qi, Pan-Jie Su, Yi-Fan Yu, Bing Li, Ye Zhao, De-Juan Zhi, Zhan-Xin Zhang, Dong-Qing Fei Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated fromEuphorbia pulcherrima. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 27, 2019 Category: Molecular Biology Authors: Chun-Xue Yu Source Type: research

Synthesis of substituted 2-alkylquinolines by visible-light photoredox catalysis
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02259G, PaperYousheng Mei, Jie Liu, Lei Wang, Pinhua Li Condensation of anilines and alkenyl ethers has been demonstrated by employing visible-light photoredox catalysis. The resulting method enables the synthesis of substituted 2-alkylquinolines under mild and simple conditions with good... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 26, 2019 Category: Molecular Biology Authors: Yousheng Mei Source Type: research

Stereoselective synthesis of 2-hydrazino-2,3-dihydrofurans via cascade Michael addition-substitution involving reaction of curcumin and other 1,3-dicarbonyls with a-hydrazinonitroalkenes
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01974J, PaperKalisankar Bera, Narasimham Ayyagari, Nishikant Satam, Irishi N Namboothiri Highly diastereoselective synthesis of 2-hydrazinated 2,3-dihydrofurans in good to excellent yields involving an interrupted Feist-Benary type reaction by treating a wide variety of 1,3-dicarbonyl compounds, including curcumins, with α-hydrazinated nitroalkenes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 26, 2019 Category: Molecular Biology Authors: Kalisankar Bera Source Type: research