Experimental and theoretical study on the cyclic(alkyl)(amino)carbene-copper catalyzed Friedel –Crafts reaction of N,N-dialkylanilines with styrenes
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02734C, PaperWentao Ma, Gaowen Zhai, Xingbang Hu, Youting Wu The Friedel –Crafts reaction of alkalinous substrates is achieved using a copper based catalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 23, 2020 Category: Molecular Biology Authors: Wentao Ma Source Type: research

Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00521E, PaperXiaoyu Yang, Fangzhi Hu, Liang Wang, Lubin Xu, Shuai-Shuai Li The hydrogen-bonding-assisted construction of tetrahydroquinolines decorated with structurally diverse 3,3 ′-difunctional groups has been realizedvia a hydride transfer-involved three-step cascade reaction in the presence of morpholine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 23, 2020 Category: Molecular Biology Authors: Xiaoyu Yang Source Type: research

Correction: Asymmetric synthesis of ( −)-solanidine and (−)-tomatidenol
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yun Wang, Guanxin Huang, Yong Shi, Wei-sheng Tian, Chunlin Zhuang, Fen-Er Chen To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 23, 2020 Category: Molecular Biology Authors: Yun Wang Source Type: research

Novel use of 2-BTSO2CF2H for the metal-free electrophilic difluoromethylthiolation of indoles
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00872A, CommunicationJun Wei, Kun Bao, Yuan Wang, Rong Sheng, Jinbo Hu Electrophilic difluoromethylthiolation of indoles with 2-BTSO2CF2H has been conducted. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded in modest to high yields under mild conditions. This is an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 22, 2020 Category: Molecular Biology Authors: Jun Wei Source Type: research

Understanding the Structures and Aromaticity of Heteroporphyrins with Computations
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00656D, PaperXiaoli Fang, Xiahe Chen, Qunmin Wang, Yun-Fang Yang, Yuan-Bin She Heteroporphyrins are the porphyrin derivatives with replacement of the pyrrolic NH moiety by other heteroatom-containing groups, such as PH, AsH, SiH2, O, S, etc. For all studied heteroporphyrins, the macrocycle... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 22, 2020 Category: Molecular Biology Authors: Xiaoli Fang Source Type: research

A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00697A, CommunicationPramila Devi, Mallikharjuna Rao Lambu, Sundarababu Baskaran A metal free method for the stereoselective synthesis of tetrahydropyrimidinone from a vinyl arene has been developed using a low melting mixture as a novel reaction medium. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Pramila Devi Source Type: research

Asymmetric N-aminoalkylation of 3-substituted indoles by N-protected N,O-acetals: an access to chiral propargyl aminals
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00795A, CommunicationJunxian Yang, Zeyuan He, Liang Hong, Wangsheng Sun, Rui Wang A direct enantioselective N1 aminoalkylation of 3-substituted indoles is efficiently catalyzed by a phosphoric acid catalyst under mild conditions, which could be applied to the modification of tryptophan containing oligopeptides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Junxian Yang Source Type: research

Synthesis of unsymmetrical disulfides via PPh3-mediated reductive coupling of thiophenols with sulfonyl chlorides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00804D, PaperDungai Wang, Xiao Liang, Mingteng Xiong, Heping Zhu, Yifeng Zhou, Yuanjiang Pan A facile and rapid synthesis of unsymmetrical aryl disulfides using PPh3-mediated reductive coupling of thiophenols with aryl sulfonyl chlorides was described. Good functional group tolerance and scalability were achieved in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Dungai Wang Source Type: research

Photochemical [2+2] Cycloaddition Reaction of Carbonyl Compounds with Danishefsky Diene
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00921K, PaperManabu Abe, Dian Agung Pangaribowo Danishefsky diene, trans-1-methoxy-3-trimethylsilyloxy-buta-1,3-diene, has been utilized in organic synthesis in thermal reactions for a long time. The purpose of this study is to investigate the photochemical reaction of ketones with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Manabu Abe Source Type: research

Enantioselective Synthesis Enabled by Visible Light Photocatalysis
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00759E, Review ArticleBor-Cherng Hong Enantioselective photoreactions have been synthetic challenge for decades. With the continuous development of modern visible light photocatalysis and asymmetric catalysis, remarkable advances have been achieved through the synergistic action of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Bor-Cherng Hong Source Type: research

C-H Functionalization of Quinazolinone by Transition Metal Catalysis
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00742K, Review ArticlePrasanjit Ghosh, Bhaskar Ganguly, Sajal Das Quinazolinone and its congeners are ubiquitous structural motifs found in numerous natural products due to their wide application as anticancer, antiviral, anti-inflammatory, antifloate and antitumor agents etc. Previously, synthetic community... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Prasanjit Ghosh Source Type: research

Differential Scanning Fluorimetry (DSF) Screen to Identify Inhibitors of Hsp60 Protein-Protein Interactions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00928H, CommunicationHao Shao, Keely Oltion, Taia Wu, Jason E. Gestwicki There are relatively few methods available for discovering inhibitors of the protein-protein interactions (PPIs) that hold together homo-oligomers. We envisioned that Differential Scanning Fluorimetry (DSF) might be a versatile way... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Hao Shao Source Type: research

Rapid access to indole-fused bicyclo[2.2.2]octanones by merging umpolung strategy and molecular iodine as a green catalyst
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01038C, CommunicationTakumi Abe, Seiya Hirao One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one are accomplished under iodine catalyst. This simple and metal-free conditions provides a practical tool to construct Csp3-rich complex molecules via oxidative... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Takumi Abe Source Type: research

Palladium-catalyzed Asymmetric Dearomative Cyclization in Natural Product Synthesis
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00818D, Review ArticleZhuo Wang Asymmetric catalysis is a rapidly growing field in modern organic chemistry and has been indispensable for the synthesis of enantioenriched materials to meet demands from the academies to pharmaceutical industries.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 21, 2020 Category: Molecular Biology Authors: Zhuo Wang Source Type: research

Recent progress of transition metal-catalysed regioselective C –H transformations based on noncovalent interactions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00703J, Review ArticleYoichiro Kuninobu, Takeru Torigoe Recent advances in the transition metal-catalysed regioselective C –H transformations controlled by noncovalent interactions between substrates and reagents or ligands are summarised. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Yoichiro Kuninobu Source Type: research

A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00114G, CommunicationJie Wang, Weipan Xu, Shuyuan Xue, Tao Yu, Hexin Xie A carbapenem-based fluorogenic reagent has been developed to detect the activity of carbapenemases, exhibiting high specificity to all carbapenemases, including both metallo carbapenemases and serine carbapenemases, over other β-lactamases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Jie Wang Source Type: research

Newly synthesized 3-sulfenylindole derivatives from 4-hydroxydithiocoumarin using an oxidative cross dehydrogenative coupling reaction (OCDCR): potential lead molecules for antiproliferative activity
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00054J, PaperSanta Mondal, Karuna Mahato, Neha Arora, Dheerendra Kankane, Umed Pratap Singh, Saghir Ali, Aftab Hossain Khan, Siddhartha S. Ghosh, Abu T. Khan Synthesis of 3-sulfenyl indole derivatives is achieved through oxidative cross-dehydrogenative coupling reaction. A few such newly synthesized compounds have also exhibited anti-proliferative activityvia reactive oxygen species mediated cell damage. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source:...
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Santa Mondal Source Type: research

Isatin as 2-Aminobenzaldehyde Surrogate: Transition Metal-free Efficient Synthesis of 2-(2 ’-Aminophenyl)benzothiazole Derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00888E, PaperManpreet Singh, Vaishali -, Avijit kumar Paul, Virender Singh A transition metal-free, convenient, and efficient practical approach has been devised for the synthesis of substituted 2-(2 ’-aminophenyl)benzothiazoles via sulfur insertion strategy using isatin derivatives as 2-aminobenzaldehyde surrogates. KI assisted one-pot... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Manpreet Singh Source Type: research

α-Angelica lactone catalyzed oxidation of benzylic sp3 C–H bonds of isochromans and phthalans
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00729C, PaperThanusha Thatikonda, Siddharth K. Deepake, Pawan Kumar, Utpal Das Oxidation of benzylic sp3 C –H bonds of isochromans and phthalans to isocoumarins and phthalides has been achieved by employing α-angelica lactone as an organocatalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Thanusha Thatikonda Source Type: research

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00814A, CommunicationJing Liu, Shi-Meng Wang, Hua-Li Qin A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, generating unique cyclobutane-fused pyridinyl sulfonyl fluoride compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Jing Liu Source Type: research

An intrinsic FRET sensor of protein –ligand interactions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00793E, PaperPatrick R. Gleason, Patrick I. Kelly, Dominic W. Grisingher, Jeremy H. Mills The non-canonical amino acidL-(7-hydroxycoumarin-4-yl)ethylglycine can serve as a FRET acceptor from tryptophan. Here, we demonstrate how this amino acid pair can be used to generate an intrinsic FRET-based sensor of protein –ligand interactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Patrick R. Gleason Source Type: research

Diastereoselective Synthesis of Spiro-Cyclopropanyl-Cyclohexadienones via Direct Sulfide-Catalyzed [2 + 1] Annulation of para-Quinone Methides with Bromides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00778A, PaperYingpeng Su, Yanan Zhao, Bingbing Chang, Qinqin Ling, Yawei Feng, Xiaolong Zhao, Danfeng Huang, Ke-Hu Wang, Cong-De Huo, Yulai Hu An efficient sulfide-catalyzed [2 + 1] annulation of para-quinone methides (p-QMs) with divers bromides has been achieved. This catalytic strategy provides an efficient and straightforward protocol for accessing a variety... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Yingpeng Su Source Type: research

Synthesis of B-ring-fluorinated ( −)-epicatechin gallate derivatives
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00686F, CommunicationDavid D. S. Thieltges, Kai D. Baumgarten, Carina S. Michaelis, Constantin Czekelius Electronically modified, fluorinated catechins and epicatechins are enantioselectively synthesized in a short, convergent sequencevia kinetic resolution. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: David D. S. Thieltges Source Type: research

Synthesis of unsymmetrical urea derivatives via one-pot sequential three-component reactions of cyclic 2-diazo-1,3-diketones, carbodiimides, and 1,2-dihaloethanes
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00683A, CommunicationXinwei He, Cheng Yang, Yinsong Wu, Mengqing Xie, Ruxue Li, Jiahui Duan, Yongjia Shang A novel and efficient multicomponent reaction of cyclic 2-diazo-1,3-diketones, carbodiimides, and 1,2-dihaloethanes has been developed, which leads to unsymmetrical urea derivatives with good yields in a single operation. This transformation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Xinwei He Source Type: research

The intermolecular anthracene-transfer in a regiospecific antipodal C60 difunctionalization
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Radu A. Talmazan, Klaus R. Liedl, Bernhard Kr äutler, Maren Podewitz The topochemically controlled regiospecific antipodal C60 difunctionalization proceedsvia an ‘inverted sandwich’ with double-decker π–π-stacking interactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 20, 2020 Category: Molecular Biology Authors: Radu A. Talmazan Source Type: research

Cu-Photoredox-Catalyzed C(sp)-C(sp3) Coupling of Redox-Active Esters with Terminal Alkynes
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00835D, PaperDa-yong Zhang, Yajing Zhang Visible-light-induced C(sp)-C(sp3) coupling of redox-active esters with terminal alkynes has been developed. The activation of carboxylic acids as their redox-active ester derivatives was important to this decarboxylative alkynylation. The strategy... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 19, 2020 Category: Molecular Biology Authors: Da-yong Zhang Source Type: research

Aromatic [b]-fused BODIPY dyes as promising near-infrared dyes
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00790K, Review ArticleJun Wang, Noel Boens, Lijuan Jiao, Erhong Hao Far-red and near-infrared (NIR) absorbing/emitting dyes have found diverse applications in biomedicine and material science. However, the absorption and emission of classical BODIPY chromophores at short wavelength hamper their applications.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 19, 2020 Category: Molecular Biology Authors: Jun Wang Source Type: research

Recent advances in the synthesis of imidazoles
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00350F, Review ArticleDmitrii A. Shabalin, Jason E. Camp The review highlights the recent advances (2018-present) in the regiocontrolled synthesis of substituted imidazoles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Dmitrii A. Shabalin Source Type: research

Calcium mediated efficient synthesis of N-arylamidines from Organic Nitriles and Amines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00805B, PaperTarun Kanti Panda, Indrani Banerjee, Shweta Sagar Amidines are preeminent categories of organic compounds having wide applications in various industries. Here, we have developed a simple one-step reaction protocol for the facile synthesis of N-arylamidines catalysed by... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Tarun Kanti Panda Source Type: research

Experimental and theoretical researches on cyclic(alkyl)(amino)carbene-copper (CAAC-Cu) catalyzed Friedel-Crafts reaction of N, N-dialkylanilines with styrenes
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02734C, PaperWentao Ma, Gaowen Zhai, Xingbang Hu, You-Ting Wu The Friedel-Crafts reaction of alkalinous substrates is challenging because the coordination between the amines and traditional acid catalyst. Based on theoretical research, we designed a catalytic process for the Friedel-Crafts... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Wentao Ma Source Type: research

Minimizing Solvent Waste in Catalytic Reactions in Highly Recyclable Hydrocarbon Solvents
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00734J, PaperSopida Thavornpradit, James Killough, David E. Bergbreiter This paper describes chemistry using organocatalysts in hydrocarbon solvents that minimizes solvent waste by using inexpensive, non-volatile, relatively inflammable, and easily recyclable poly( α-olefin)s (PAOs) as hydrocarbon solvents. These studies show... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Sopida Thavornpradit Source Type: research

Meisenheimer complexes as hidden intermediates in the aza-SNAr mechanism
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00600A, PaperRodrigo Ormazabal-Toledo, Sebastian Richter, Andres Robles-Navarro, Boris Maulen, Ricardo Matute, Sebasti án Gallardo-Fuentes In this work we report a computational study about the aza-S N Ar mechanism in fluorine- and chlorine- containing azines with the aim to unravel the physical factors that determine... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Rodrigo Ormazabal-Toledo Source Type: research

Modular Control of L-Tryptophan Isotopic Labelling via an Efficient Biosynthetic Cascade
We report a biosynthetic-cascade synthesis of Trp isotopologs starting from indole, glycine, and formaldehyde using the enzymes L-threonine aldolase and an engineered... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Clayton M Thompson Source Type: research

Synthesis of quinazoin-4-ones through acid ion exchange resin mediated cascade reaction
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00881H, PaperHuiyong Yang, Jun Xu, Yilan Zhang, Lei He, Peng-Fei Zhang, Wanmei Li An interesting cascade reaction of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide in the presence of acid ion exchange resin is described. In this reaction, a range of substrates bearing various substituent groups are well compatible.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 18, 2020 Category: Molecular Biology Authors: Huiyong Yang Source Type: research

Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00225A, Communicationfangpeng hu, Xinfeng Cui, Guoqiang Lu, Guosheng Huang A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6 π electron cyclization in the presence of a Lewis... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 16, 2020 Category: Molecular Biology Authors: fangpeng hu Source Type: research

Hierarchical self-assembly of an azobenzene dyad with inverted amide connection into toroidal and tubular nanostructures
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00833H, CommunicationTakuho Saito, Shiki Yagai Inversion of the amide connectivity of an azobenzene dyad, which self-assembles into chiral toroids and nanotubes, improves the thermal stability of the assemblies, however it negatively affects supramolecular chirality. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2020 Category: Molecular Biology Authors: Takuho Saito Source Type: research

Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00084A, PaperE Zhang, Heng Guo, Dandan Chen, Qian Yang, Yafei Fan, Yu Yin, Wengui Wang, Daijie Chen, Shoufeng Wang, Wen Liu The target product 6 ′-fluoro-nosiheptide (6′-F-NOS), along with 6′-fluoro-nosiheptide intermediate (NOS 6′-F-NOSint), was obtained by mutational biosynthesisvia 6 ′-fluoro-MIA feeding into mutant NosL. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2020 Category: Molecular Biology Authors: E Zhang Source Type: research

Asymmetric N-Aminoalkylation of 3-Substituted Indoles by N- protected N,O-acetals: An Access to Chiral Propargyl Aminals
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00795A, CommunicationJunxian Yang, Zeyuan He, Liang Hong, Wangsheng Sun, Rui Wang A direct enantioselective N1 aminoalkylation of 3-substituted indoles is efficiently catalyzed by a phosphoric acid catalyst under mild conditions to afford diverse enantioenriched propargyl aminals. The strategy could be applied... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 15, 2020 Category: Molecular Biology Authors: Junxian Yang Source Type: research

Visible-light-mediated borylation of aryl and alkyl halides with a palladium complex
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00028K, CommunicationJiahui Zhao, Zhao-Zhao Zhou, Yue Zhang, Xuan Su, Xi-Meng Chen, Yong-Min Liang Palladium catalyzed visible-light-mediated borylation of inactivated aryl and alkyl halides was reported, the method had high yield and excellent functional group compatibility. Furthermore, arylsilicate were synthesized selectively by dimethylphenylsilyl boronic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Jiahui Zhao Source Type: research

Synthesis of Hydrophilic Caged DAG-lactones for Chemical Biology Applications
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00807A, PaperT Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura The 6-bromo-7-hydroxy-coumarin-4-ylmethyl (Bhc) group has been used widely in cage chemistry because of its high molar absorptivity and photolytic efficiency. One of the drawbacks of coumarins however is their low... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: T Kobayakawa Source Type: research

Novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in low melting mixture
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00697A, CommunicationSundarababu Baskaran, Pramila Devi, Malik L A direct and metal free one-pot method has been developed for the stereoselective synthesis of tetrahydropyrimidinone derivatives from vinyl arene and formaldehyde using tartaric acid-dimethylurea (TA:DMU) melt as a green... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Sundarababu Baskaran Source Type: research

General dual functionalisation of biomacromolecules via a cysteine bridging strategy
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Stephen J Walsh, jessica iegre, Hikaru Seki, Jonathan Bargh, Hannah Sore, Jeremy Parker, Jason S Carroll, David R Spring Site-selective modification of peptides and proteins has resulted in the development of a host of novel tools for the study of cellular systems or the synthesis of enhanced biotherapeutics. There... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Stephen J Walsh Source Type: research

Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Robin L. Brabham, Tessa Keenan, Annika H üsken, Jacob Bilsborrow, Ryan McBerney, Vajinder Kumar, W Bruce Turnbull, Martin A Fascione The α-oxo aldehyde is a highly reactive aldehyde for which many protein bioconjugation strategies exist. Here, we explore the genetic incorporation of a threonine-ε-lysine dipeptide into proteins, harbouring a “masked”... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Robin L. Brabham Source Type: research

Synthesis of the protected α- amino acid via decarboxylation amination from malonate derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00677G, PaperHui Fu, Peihe Li, Zheng Wang, Xiaoying Li, Qipu Dai, Changwen Hu A general and efficient strategy for the synthesis of the protected α-amino acid is reported. The method use malonate derivatives as the starting materials and Cs2CO3 as base at 60... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Hui Fu Source Type: research

The Breaking Beads Approach for Photocleavage from Solid Support
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00821D, CommunicationYasmeen Bakhatan, Israel Alshanski, Dana Grunhaus, Mattan Hurevich Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. Photocleavage from intact porous polystyrene beads is not optimal because light cannot penetrate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Yasmeen Bakhatan Source Type: research

An intrinsic FRET sensor of protein-ligand interactions
We describe an approach for the development of fluorescent sensors of metabolite binding in which a genetically encoded fluorescent non-canonical amino acid (fNCAA) containing a 7-hydroxycoumarin moiety (7-HCAA) forms a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 14, 2020 Category: Molecular Biology Authors: Patrick R. Gleason Source Type: research

Electrochemically enabled functionalization of indoles or anilines for the synthesis of hexafluoroisopropoxy indole and aniline derivatives
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00157K, CommunicationZu-Yu Mo, Xin-Yu Wang, Yu-Zhen Zhang, Li Yang, Hai-Tao Tang, Ying-Ming Pan We have developed an efficient electrochemical method for selective functionalization ofN-acetylindole or aniline derivatives with hexafluoroisopropanol to obtain a series of hexafluoroisopropoxy indoles and anilines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 13, 2020 Category: Molecular Biology Authors: Zu-Yu Mo Source Type: research

Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA
We report on the design of new siRNA-binding fluorescent probes with the improved detection selectivity toward intact double-stranded siRNAs over single-stranded forms by the conjugation of pyrene unit into thiazole... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 13, 2020 Category: Molecular Biology Authors: Yusuke Sato Source Type: research

Acylation of oxindoles using methyl/phenyl esters via the mixed Claisen condensation – an access to 3-alkylideneoxindoles
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00789G, CommunicationRamdas Sreedharan, Purushothaman Rajeshwaran, Pradeep Kumar Reddy Panyam, Saurabh Yadav, C. M. Nagaraja, Thirumanavelan Gandhi A straightforward protocol to acylate oxindoles using methyl and phenyl esters mediated by LiHMDS and KOtBu respectivelyvia the mixed Claisen condensation under mild reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 13, 2020 Category: Molecular Biology Authors: Ramdas Sreedharan Source Type: research

Divergent syntheses of okaramines C, J, L, and S –U
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00587H, CommunicationXiao-Wan Li, Tong-Xu Si, Ya-Ping Liu, Ming-Zhong Wang, Albert S. C. Chan The first total synthesis of okaramines L and S –U, and the concise synthesis of okaramines C and J have been accomplished using a common intermediate bromohexahydropyrroloindole in 5–8 steps with an overall yield of 6.7%–23.0%. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 13, 2020 Category: Molecular Biology Authors: Xiao-Wan Li Source Type: research