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Kinetic resolution of 1,1 ′-binaphthyl-2,2′-diamine derivatives by chiral calcium phosphate-catalyzed acylation
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00355A, PaperTatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Tatsuhiro Uchikura Source Type: research

Copper catalyzed dehydrogenative cyclization, alkenylation towards dihydroquinolinones
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00134F, PaperPari Keerthana, Fazlur-Rahman Nawaz Khan An efficient copper-catalysized one-pot sequential synthesis of alkenylated quinolinyldihydroquinolinones is reported utilizing ketones, 1,3-cyclohexanediones, and benzyl alcohols via dehydrogenative cyclisation, followed by alkenylation. This highly straightforward method provides a mild... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Pari Keerthana Source Type: research

Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuma Matsuura, Shinichiro Fuse Various 2,5-disubstituted furans were synthesizedvia 5-substituted 2-halomethylfurans using microflow technology. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Yuma Matsuura Source Type: research

Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00402G, PaperYuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari Post-synthetic conversion of the trifluoromethyl group to a heteroaryl group at the C5 position of the pyrimidine base in the oligonucleotide was achieved. Specifically, oligonucleotides containing 5-trifluoromethylpyrimidine bases were treated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Yuta Ito Source Type: research

On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Julia A. Turner, Hendrik Zipse, Mark S. Taylor Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Julia A. Turner Source Type: research

Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00404C, PaperTatiana Gerasimova, Almaz Zagidullin, Anastasiya Nikolaeva, Robert R. Fayzullin, Alya Saitova, Vasily Miluykov, Stefan Grimme, Sergey Katsyuba Combined UV-vis and quantum chemical studies of the structural flexibility and tautomerism of 6-R-3-hydroxy-2-pyrazine carboxamides in solutions revealed that their keto-enol transformations are accompanied by deprotonation of the enol tautomers... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Tatiana Gerasimova Source Type: research

3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3+2]-cycloaddition with arynes. Synthesis of substituted 3-vinyl-1,2-benzisoxazoles
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00391H, CommunicationAlexander A. Lukoyanov, Svetlana Aksenova, Andrey Tabolin, Alexey Yu. Sukhorukov The reaction of 3-halo-5,6-dihydro-4H-1,2-oxazine N-oxides with arynes was studied. Arynes were generated from o-silylaryl triflates and underwent consecutive [3+2]-cycloaddition/[4+2]-cycloreversion with N-oxides leading to substituted 3-vinyl-benzisoxazoles in high yields. In the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Alexander A. Lukoyanov Source Type: research

Regioselective Synthesis of 4-Arylamino-1,2-Naphthoquinones in Eutectogel as a Confined Reaction Media using LED Light
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00140K, CommunicationNagarajan Subbiah, Vara Prasad Rebaka, Yogendra Kumar, Arun Kumar Rachamalla, Tohira Banoo Predicting the selectivity and conversion in a confined reaction media under photochemical condition is highly challenging as compared to the conventional synthesis. Herein, we report the use of a simple... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Nagarajan Subbiah Source Type: research

Electrochemical Nickel-Catalyzed Cross-Coupling of Glycosyl Thiols with Preactivated Phenols and Ketones
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00442F, CommunicationFuxin Li, Hui Liu, Wanyu Xing, Qing-Ju Zhang, Liming Wang An efficient electrochemical nickel-catalyzed cross-coupling reaction was reported here for synthsis of S-glycosides from preactivated phenols and ketones under mild condition. Various glycosyl thiols, including unprotected sugar, and a diverse... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Fuxin Li Source Type: research

TEMPO/PhI(OAc)2 promoted the aminophosphinoylation of alcohols with amines and H-phosphine oxides in the aqueous phase
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00302K, CommunicationQiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao A novel and environmentally friendly method for synthesizing α-aminophosphine oxides in the aqueous phase, using Ar2P(O)−H reagents, alcohols and amines, has been disclosed for the first time. This method allows... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Qiang Huang Source Type: research

Asymmetric total synthesis of humulane sesquiterpenoids alashanoids B, C, E, F and 2,9-humuladien-6-ol-8-one
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00393D, PaperSamik Nanda, Rasmita Barik Naturally occurring sesquiterpenes having humulane framework are structurally intriguing and possess significant biological profiles. Asymmetric synthesis of alashanoids B-C, E-F and 2,9-humuladien-6-ol-8-one is achieved for the first time through a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 10, 2024 Category: Molecular Biology Authors: Samik Nanda Source Type: research

Coumarin –azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00312H, PaperI. Caroline Vaaland Holmgard, Aday Gonz ález-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck Coumarin –azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activityin vitro and no neurotoxicity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 9, 2024 Category: Molecular Biology Authors: I. Caroline Vaaland Holmgard Source Type: research

Metal- and light-free decarboxylative direct C –H alkylation of heteroarenes at room temperature
This study reports a metal- and light-free decarboxylative C –H alkylation of heteroarenes at room temperature. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 9, 2024 Category: Molecular Biology Authors: Tong-Bo Zhang Source Type: research

Copper-Catalyzed Asymmetric Friedel-Crafts Hydroxyalkylation of Pyrazole-4,5-diones with  5-Aminoisoxazoles
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00322E, CommunicationSiyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang An asymmetric Friedel-Crafts hydroxyalkylation reaction of 5-aminoisoxazoles with pyrazole-4,5-diones was developed under the catalysis of 5% chiral copper complexes. This reaction exhibits a functional group tolerance and excellent enantioselectivity. Moreover,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 9, 2024 Category: Molecular Biology Authors: Siyu Gao Source Type: research

Mechanisms of Constructing C-O Bond, H2O and CH3OH as the Oxygen Source, catalyzed by DDQ: A DFT Investigation
In this study, we investigated the photo-catalytic mechanisms involved in the construction of C-O bonds from arenes (benzene, 2',6'-dimethyl-[1,1'-biphenyl]-2-carboxylic acid, or 2,4-dichloro-1-fluorobenzene), catalyzed by 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ). Computational analyses were conducted... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 9, 2024 Category: Molecular Biology Authors: Xiufang Zheng Source Type: research