Synthetic and Mechanistic Aspects of Sulfonyl Migrations
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02587A, Review ArticleAnita R Maguire, Aaran J Flynn, Alan Ford Over the past 20 years reports of sulfonyl migrations have appeared frequently described as ‘unusual’ and ‘unexpected’. This comprehensive review compiles, for the first time, sulfonyl migrations reported over the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 4, 2020 Category: Molecular Biology Authors: Anita R Maguire Source Type: research

Synthesis of 3-acylindoles via copper-catalysed oxidative decarbethoxylation of ethyl arylacetates
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02550B, PaperAnjali Jaiswal, Anup Kumar Sharma, Krishna Nand Singh An efficient regioselective C-3 acylation of free indoles (N-H) has been accomplished via oxidative decarbethoxylation of easily available ethyl arylacetates using Cu(OAc)2 and KOtBu in DMSO. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 4, 2020 Category: Molecular Biology Authors: Anjali Jaiswal Source Type: research

Cascade and multicomponent synthesis of structurally diverse 2-(pyrazol-3-yl)pyridines and polysubstituted pyrazoles
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02691F, PaperRaquel Barroso, Mar ía-Paz Cabal, Azucena Jiménez, Carlos Valdes The cascade reaction between N-tosylhydrazones and 2-alkynylpyridines leads to 2-(pyrazol-3-yl)pyridines, important structural motifs in ligands for transition metals and bioactive molecules. When the reaction is conducted with 2,6-diethynylpyridine the important... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 4, 2020 Category: Molecular Biology Authors: Raquel Barroso Source Type: research

π-Extended push-pull azo-pyrrole compounds: Synthesis, solvatochromic properties and determination of optical band gaps
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02410G, PaperJenny A. Balam-Villarreal, Byron Jos é López Mayorga, David Gallardo-Rosas, Ruben Alfredo Toscano, Maria del Pilar Carreon-Castro, Vladimir A. Basiuk, Fernando Cortes-Guzman, José G. López-Cortés, M. Carmen Ortega-Alfaro A new family of push-pull biphenyl-azopyrrole compounds 3b-g and 4b-d was efficiently obtained via a Suzuki cross-coupling reaction, between 2-(4 ’-Iodophenyl-azo)-N-methyl pyrrole (1a) or 3-(4’-Iodophenyl-azo)-1,2,5-trimethyl pyrrole (2a) and 4’-substituted phenyl boronic... The...
Source: RSC - Organic and Biomolecular Chemistry - February 4, 2020 Category: Molecular Biology Authors: Jenny A. Balam-Villarreal Source Type: research

6-Deoxy-6-fluoro galactofuranosides: Regioselective glycosylation, unexpected reactivity, and anti-leishmanial activity.
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02596K, PaperJeane VAUGENOT, Abderrafek El Harras, Olivier TASSEAU, Remi Marchal, Laurent Legentil, Boris Le Guennic, Thierry Benvegnu, Vincent Ferrieres Selective glycosylation of the C-6 fluorinated galactofuranosyl acceptor 2 was studied with four galactofuranosyl donors. It was highlighted that this electron-withdrawing atom strongly impacted the behavior of the acceptor, thus... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 4, 2020 Category: Molecular Biology Authors: Jeane VAUGENOT Source Type: research

Rhodium(III)-catalyzed ortho-C –H amidation of 2-arylindazoles with a dioxazolone as an amidating reagent
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02756D, CommunicationPayel Ghosh, Sadhanendu Samanta, Alakananda Hajra A simple and efficient method for directed amidation of a wide range of 2-arylindazoles has been established for the first time through a rhodium-catalyzed C –H activation reaction with alkyl, aryl and heteroaryl dioxazolones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 3, 2020 Category: Molecular Biology Authors: Payel Ghosh Source Type: research

γ-C(sp3)-H bond functionalisation of α,β-unsaturated amides through an umpolung strategy
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00125B, CommunicationMasafumi Ueda, Norihiko Takeda, Erika Futaki, Motohiro Yasui, Tetsuro Shinada, Okiko Miyata The nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides have been developed. This umpolung reaction allows the regioselective introduction of phenyl and alkyl groups to a vinylketeneN,O-acetal, which is generated in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 3, 2020 Category: Molecular Biology Authors: Masafumi Ueda Source Type: research

Asymmetric synthesis of dihydrocoumarins via catalytic sequential 1,6-addition/transesterification of α-isocyanoacetates with para-quinone methides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02652E, PaperMei-Xin Zhao, Juan Xiang, Zi-Qiang Zhao, Xiao-li Zhao, Min Shi A catalytic asymmetric synthesis of 3,4-dihydrocoumarins with adjacent tertiary-quaternary stereocenters by 1,6-addition/transesterification cascade reaction of α-isocyanoacetates with ortho-hydroxyphenyl-substituted para-quinone methides (p-QMs) had been developed. Using a combination of dihydroquinidine-derived aminophosphine... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 1, 2020 Category: Molecular Biology Authors: Mei-Xin Zhao Source Type: research

The strategic use of para-quinone methides to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides from unprotected carbohydrate amines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00039F, CommunicationRekha Sangwan, Atul Dubey, Ashwani Tiwari, Pintu Kumar Mandal A practical route to access synthetically challenging and chemoselective α,α′-diarylmethylN-glycosidesvia Sc(OTf)3-catalyzed 1,6-conjugate addition of unprotected amino sugars withp-QMs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 1, 2020 Category: Molecular Biology Authors: Rekha Sangwan Source Type: research

Rh-Catalyzed aldehydic C –H alkynylation and annulation
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02670C, PaperMaddali L. N. Rao, Boddu S. Ramakrishna Novel Rh-catalyzed aldehydic C –H bond alkynylation and annulation for thein situ synthesis of chromones and aurones are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 1, 2020 Category: Molecular Biology Authors: Maddali L. N. Rao Source Type: research

Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure –property relationships
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Peter R. Bradshaw, Selena E. Richards, Ian D. Wilson, Andrew V. Stachulski, John C. Lindon, Toby J. Athersuch Detailed kinetic and transition structure modelling to rationalise the differences in reactivity observed between the acyl glucuronide and glucoside metabolites of a series of phenylacetic acid analogues. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 31, 2020 Category: Molecular Biology Authors: Peter R. Bradshaw Source Type: research

A new skeletal rearrangement of 1,7-dimethyl Cookson's cage dione catalyzed by a Lewis acid
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02298H, PaperSambasivarao Kotha, Subba Rao Cheekatla An unexpected fragmentation of the pentacycloundecane (PCUD) framework delivers two unusual polycycles in an unprecedented approachvia an extensive C –C bond reorganization promoted by the BF3·MeOH complex. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 30, 2020 Category: Molecular Biology Authors: Sambasivarao Kotha Source Type: research

Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00034E, CommunicationJohann Rogier, Lilia Anani, Aur élien Coelho, Fabien Massicot, Carine Machado-Rodrigues, Jean-Bernard Behr, Jean-Luc Vasse The diastereoselective conjugate addition of chiral secondary lithium homoallylamides to α,β-unsaturated esters, providing tertiary amines bearing two chains integrating a stereogenic center adjacent to the nitrogen atom, is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Orga...
Source: RSC - Organic and Biomolecular Chemistry - January 30, 2020 Category: Molecular Biology Authors: Johann Rogier Source Type: research

Selective C –H dithiocarbamation of arenes and antifungal activity evaluation
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02514F, PaperZhuo-Bin Huang, Xiong-Jian Xia, Zi-Hao Huang, Li Xu, Xiao-Yong Zhang, Ri-Yuan Tang Environmentally benign synthesis of N-heterocyclic dithiocarbamates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 30, 2020 Category: Molecular Biology Authors: Zhuo-Bin Huang Source Type: research

A FRET-based ratiometric fluorescent probe to detect cysteine metabolism in mitochondria
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00002G, Paperxiaojing han, Zhiyao Zhai, Xiaopeng Yang, Di Zhang, jun tang, Jianming Zhu, xiaofei zhu, Yong Ye As an important biothiol in living cells, cysteine closely related to oxidative damage in living organisms. Sulfite from cysteine metabolism in living cells plays a crucial role in maintaining organism... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 30, 2020 Category: Molecular Biology Authors: xiaojing han Source Type: research

Diketopyrrolopyrrole –fullerene C60 architectures as highly efficient heavy atom-free photosensitizers: synthesis, photophysical properties and photodynamic activity
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02487E, PaperMaximiliano L. Agazzi, Vitor Almovodar, Natalia S Gsponer, Sonia Graciela Bertolotti, Augusto Tom é, Edgardo Nestor Durantini Chromophore-fullerene C60 hybrids present interesting properties to act as heavy atom-free photosensitizers and reactive oxygen species (ROS) producers. Here, two new diketopyrrolopyrrole –C60 conjugates were efficiently synthesized and characterized. Conjugates show... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 30, 2020 Category: Molecular Biology Authors: Maximiliano L. Agazzi Source Type: research

One-pot synthesis of 2-azolylimidazole derivatives through a domino addition/A3 coupling/cyclization process under copper catalysis
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02532D, PaperYifan Lin, Erfei Li, Xin Wu, Luyu Wang, Haofeng Wang, Xiaoyu Li, Honglan Kang, Liejin Zhou, Guodong Shen, Xin Lv A novel one-pot approach to the synthesis of multi-substituted 2-imidazolylimidazoles, 2-pyrazolylimidazoles and 2-indazolylimidazoles was developed through a domino addition/A3 coupling/cyclization process under copper catalysis. A variety of aminoethyl- or hydroxylethyl-tethered... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 30, 2020 Category: Molecular Biology Authors: Yifan Lin Source Type: research

Cucurbit[7]uril as a catalytic nanoreactor for one-pot synthesis of isoxazolidines in water
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02352F, PaperDavide Gentile, Giuseppe Floresta, Vincenzo Patamia, Angelo Nicosia, Placido G. Mineo, Antonio Rescifina The main objective of supramolecular chemistry is to mimic the macrosystems present in nature, a goal that fits perfectly with the green chemistry guidelines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 29, 2020 Category: Molecular Biology Authors: Davide Gentile Source Type: research

Chemical transformations of quaternary ammonium salts via C –N bond cleavage
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02667C, Review ArticleZhong-Xia Wang, Bo Yang The reaction of quaternary ammonium saltsvia C –N bond cleavage to construct C–C, C–H and C–heteroatom bonds is summarized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 29, 2020 Category: Molecular Biology Authors: Zhong-Xia Wang Source Type: research

Rhodium(III)-catalyzed isoquinoline derivatives synthesis from allyl carbonates and benzimidates with hydrogen evolution
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02553G, PaperLin Dong, Chao Li, Huibei Xu, Jing Zhang, Man Liu A novel Rh(III)-catalyzed cascade C −H activation/cyclization approach to access isoquinoline derivatives from benzimidates and available allyl carbonates with the liberation of H2 has been realized. Allyl carbonates were first used... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 29, 2020 Category: Molecular Biology Authors: Lin Dong Source Type: research

Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02453K, Review ArticleMarjorie Cepeda Plaza, Alessio Peracchi DNAzymes (deoxyribozymes) are short single-stranded DNA molecules endowed with catalytic activity, obtained by in vitro selection. In the past 25 years, dozens of DNAzymes have been isolated, characterized and employed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 29, 2020 Category: Molecular Biology Authors: Marjorie Cepeda Plaza Source Type: research

Elucidation of the Atroposelectivity in the Synthesis of Axially Chiral Thiohydantoin Derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02556A, PaperZeynep Pinar Haslak, Sesil Agopcan Cinar, Sevgi Sarigul Ozbek, Gerald Monard, Ilknur Dogan, Viktorya Aviyente Recently, Sarigul and Dogan have synthesized a number of enantiomerically enriched axially chiral atropoisomeric 2-thiohydantoins by the reaction of L-amino acid ester salts and o-aryl isothiocyanates in the presence of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 29, 2020 Category: Molecular Biology Authors: Zeynep Pinar Haslak Source Type: research

Chimeric γPNA–Invader probes: using intercalator-functionalized oligonucleotides to enhance the DNA-targeting properties of γPNA
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02726B, PaperRaymond G. Emehiser, Patrick J. Hrdlicka Chimeric γPNA–Invader probes are energetically activated to recognize complementary double-stranded (ds) DNA targets and engineered to reduce γPNA dimerization and improve the specificity of the recognition processvis- à-vis single-stranded γPNAs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Raymond G. Emehiser Source Type: research

Rhodium(III)-catalyzed ortho-C −H amidation of 2-arylindazoles with dioxazolone as an amidating reagent
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02756D, CommunicationAlakananda Hajra, Payel Ghosh, Sadhanendu Samanta A simple and efficient method for the directed amidation of a wide range of 2-arylindazoles has been established for the first time through a rhodium-catalyzed C −H activation reaction with alkyl,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Alakananda Hajra Source Type: research

First Enantioselective Synthesis of Gingesulfonic Acids and Unequivocal Determination of their Absolute Stereochemistry.
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02662B, CommunicationMauro F A Adamo, Grazia Bencivenni, Maria Moccia, Andrea Ravelli, Malachi W Gillick Healy, Brian G Kelly Herein we report the first organocatalysed enantioselective synthesis of gingesulfonic acids and shogasulfonic acids via a mild and convenient aminothiourea-catalysed conjugate addition of bisulfite to the olefin moiety of α,β-unsaturated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Mauro F A Adamo Source Type: research

Stereodivergent routes in organic synthesis: Marine natural products, lactones, other natural products, heterocycles and unnatural compounds
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02597A, Review ArticleCarmen Najera, Francisco Foubelo, Jos é Sansano, Miguel Yus Enantio- and diastereodivergent routes to marine-origin natural products with different size of cyclic ethers and lactones have been carried out in order to assign stereochemical features. Kainoid amino acids such... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Carmen Najera Source Type: research

Synthesis of chromone-containing polycyclic compounds via palladium-catalyzed [2 + 2 + 1] annulation
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02690H, PaperMi-Zhuan Li, Qi Tong, Wen-Yong Han, Si-Yi Yang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen A variety of chromone-containing polycyclic compounds are efficiently constructed in good yields with excellent diastereoselectivitiesvia palladium-catalyzed [2 + 2 + 1] annulation of 3-iodochromones, α-bromo carbonyl compounds, and tetracyclododecene. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Mi-Zhuan Li Source Type: research

Copper-Catalyzed and Additive Free Decarboxylative Trifluoromethylation of Aromatic and Heteroaromatic Iodides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02635E, PaperMartin Bundgaard Johansen, Anders Thyboe Lindhardt A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Martin Bundgaard Johansen Source Type: research

Visible-Light-Driven Metal-Free Aerobic Synthesis of Highly Diastereoselective Phosphinoylpyrroloindoles
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02730K, CommunicationRamesh Gorre, Damodar Enagandhula, Sridhar Balasubramanian, Srirama Murthy Akondi A visible-light-driven metal-free phosphorus radical mediated construction of 2-phosphinoyl-3H-pyrrolo[1,2,a]indoles is described. This mild tandem phosphinoylation/cyclization protocol utilizes air as a green oxidant and proceeds in a short span of time... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 27, 2020 Category: Molecular Biology Authors: Ramesh Gorre Source Type: research

Selective C-H Dithiocarbamation of Drug Skeletons and their Antifungal Activity
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02514F, PaperZhuo-Bin Huang, Xiong-Jian Xia, Zi-Hao Huang, Li Xu, Xiaoyong Zhao, Riyuan Tang This paper discloses a metal-free selective C-H dithiocarbamation of drug skeletons using disulfiram (DSF) in the presence of KI/K2S2O8 in DMF/H2O. Drug skeletons, including 5-aminopyrazoles, indoles, pyrroloquinoline, and Julolidine, underwent... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 25, 2020 Category: Molecular Biology Authors: Zhuo-Bin Huang Source Type: research

Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02675D, Review ArticleC éline Sperandio, Jean Rodriguez, Adrien Quintard This review highlights the different enantioselective catalyst-controlled cascades creating multiple alcohol functions and ensuring through subsequent simple derivatization, the rapid preparation of extended 1,3-polyols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 24, 2020 Category: Molecular Biology Authors: C éline Sperandio Source Type: research

Sequential multicomponent site-selective synthesis of 4-iodo and 5-iodopyrrole-3-carboxaldehydes from a common set of starting materials by tuning the conditions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02501D, PaperSachin Choudhary, Jyothi Yadav, Mamta, Amol Prakash Pawar, Satheeshvarma Vanaparthi, Nisar A. Mir, Eldhose Iype, Ratika Sharma, Rajni Kant, Indresh Kumar A simple and straightforward method for the synthesis of 4-iodo and 5-iodopyrrole-3-carboxaldehydes is developed in good to high yields (up to 78%) from a common set of starting materials by tuning the reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and...
Source: RSC - Organic and Biomolecular Chemistry - January 24, 2020 Category: Molecular Biology Authors: Sachin Choudhary Source Type: research

Boric acid catalyzed chemoselective reduction of quinolines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02673H, PaperDipanjan Bhattacharyya, Sekhar Nandi, Priyanka Adhikari, MONURANJAN KONWAR, Bikash Kumar Sarmah, Animesh Das Boric acid promoted transfer hydrogenation of substituted quinolines to synthetically versatile 1,2,3,4-tetrahydroquinolines (1,2,3,4-THQs) was described under mild reaction conditions using Hantzsch ester as a mild organic hydrogen source. This methodolgy... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 24, 2020 Category: Molecular Biology Authors: Dipanjan Bhattacharyya Source Type: research

Copper-mediated oxidative [3+2]-annulation of nitroalkenes and pyridinium imines: efficient synthesis of 3-fluoro- and 3 nitro-pyrazolo[1,5-a]pyridines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02668A, PaperVladimir Motornov, Andrey Tabolin, Yulia V. Nelyubina, Valentine Nenajdenko, Sema Ioffe An efficient route to pyrazolo[1,5-a]pyridines by Cu(OAc)2 ∙H2O-promoted oxidative [3+2]-annulation of nitroalkenes with in situ generated pyridinium imines was developed. The reaction with α-fluoronitroalkenes provides the first preparative synthesis of 3-fluoro-pyrazolo[1,5-a]pyridines.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 24, 2020 Category: Molecular Biology Authors: Vladimir Motornov Source Type: research

Johnson –Corey–Chaykovsky Fluorocyclopropanation of Double Activated Alkenes: Scope and Limitations
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02712B, PaperArmands Kazia, Renate Melngaile, Anatoly Mishnev, Janis Veliks Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes utilizingS‐monofluoromethyl‐S‐phenyl‐2,3,4,5‐tetramethylphenylsulfonium tetrafluoroborate is an efficient approach to obtain a range of monofluorocyclopropane derivatives. So far, fluoromethylsulfonium salts display the broadest scope for direct... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 24, 2020 Category: Molecular Biology Authors: Armands Kazia Source Type: research

Recent progress in the total synthesis of Strychnos alkaloids
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02627D, Review ArticleWeigang He, Pengyan Wang, Junhan Chen, Weiqing Xie The recent synthetic approaches towardStrychnos alkaloids are summarized, including novel synthetic methodologies and strategies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Weigang He Source Type: research

A lysosome-targeted near-infrared fluorescent probe for imaging of acid phosphatase in living cells
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02188D, PaperSongtao Cai, Chang Liu, Xiaojie Jiao, Song He, Liancheng Zhao, Xianshun Zeng A lysosome-targeted near-infrared (NIR) fluorescent probeSHCy-P for the detection and imaging of ACP in living cells has been designed and developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Songtao Cai Source Type: research

Recent advances in the direct β-C(sp2)–H functionalization of enamides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02649E, Review ArticleTonghao Zhu, Shimin Xie, Pornchai Rojsitthisak, Jie Wu Recent advances in the direct β-C(sp2) –H functionalization of enamides, mainly including arylation, alkenylation, alkynylation, alkylation, acylation, sulfonylation, phosphorylation, and others, are reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Tonghao Zhu Source Type: research

Recent progress on the organic and metal complex-based fluorescent probes for monitoring nitric oxide in living biological systems
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02561H, Review ArticleLizhen Wang, Juan Zhang, Xue An, Hongdong Duan Nitric oxide (NO) is an important gaseous signaling molecule related to various human diseases. To investigate the biological functions of NO, many strategies have been developed for real-time monitoring the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Lizhen Wang Source Type: research

Strategic use of para-quinone methides to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides from unprotected carbohydrate amines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00039F, CommunicationPintu Kumar Mandal, Rekha Sangwan, Atul Dubey, Ashwani Tiwari Reported herein is a practical route to access synthetically challenge and chemoselective α,α′-diarylmethyl N-glycosides via Sc(OTf)3-catalyzed 1,6-conjugate addition of amino sugars with para-quinone methides (p-QMs). The reactions proceed smoothly without... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Pintu Kumar Mandal Source Type: research

Homoallylic amines as efficient chiral inducing framework in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00034E, Communicationjohann rogier, Lilia Anani, Aur élien Coelho, Fabien Massicot, Carine Machado-Rodrigues, jean-bernard behr, jean-luc vasse The diastereoselective conjugate addition of secondary homoallylamines, obtained in the enantioenriched form via allylmetallation of imines, onto α,β-unsaturated esters is reported. Leading to tertiary amines bearing two chains integrating a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: johann rogier Source Type: research

Sequential conjugation methods based on triazole formations and related reactions using azides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02698C, Review ArticleSuguru Yoshida The recent remarkable progress of azide chemistry has realized sequential conjugation methods by selective 1,2,3-triazole formations. On the basis of diverse reactivities of azides and azidophiles including terminal alkynes and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Suguru Yoshida Source Type: research

Self-assembling purine and pteridine quartets: how do π-conjugation patterns affect resonance-assisted hydrogen bonding?
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02412C, CommunicationHari Ram Paudel, Ranjita Das, Chia-Hua Wu, Judy I. Wu π-Conjugation patterns determine the association strengths of purine and pteridine quartets. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Hari Ram Paudel Source Type: research

A newskeletal rearrangement of 1,7-dimethyl Cookson ’s cage dione catalyzed by Lewis acid
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02298H, PaperSambasivarao Kotha, Subba Rao Cheekatla Methyl-substituted polycyclic cage dione containing the PCUD framework has undergone an unprecedented ring rearrangement approach. Here, the PCUD framework with the aid of Lewis acid such as BF3.MeOH gave unusual... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2020 Category: Molecular Biology Authors: Sambasivarao Kotha Source Type: research

Solid-phase synthesis of branched oligonucleotides containing a biologically relevant dCyd341 interstrand crosslink DNA lesion
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB01021A, PaperMarisa L. Taverna Porro, Christine Saint-Pierre, Didier Gasparutto, Jean-Luc Ravanat Branched oligonucleotides containing a biologically relevant DNA lesion, involving an interstrand crosslink between a cytosine base on one strand and a ribose moiety on the opposite strand, were prepared in a single automated solid-phase synthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 21, 2020 Category: Molecular Biology Authors: Marisa L. Taverna Porro Source Type: research

Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02642H, Review ArticleRenzhi Chen, Sihan Yang, Yandong Zhang In this review, we summarize five instructive total syntheses of marine brominated sesquiterpene aplydactone developed over the past five years. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 21, 2020 Category: Molecular Biology Authors: Renzhi Chen Source Type: research

Cucurbit[7]uril as a catalytic nanoreactor for one-pot synthesis in water of isoxazolidines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02352F, PaperDavide Gentile, Giuseppe Floresta, Vincenzo Patamia, Angelo Nicosia, Placido Mineo, Antonio Rescifina The main objective of supramolecular chemistry is to mimic the macrosystems present in nature. A goal that fits perfectly with the green chemistry guidelines. The aim of our work is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 21, 2020 Category: Molecular Biology Authors: Davide Gentile Source Type: research

The synthesis of unnatural α-alkyl- and α-aryl-substituted serine derivatives
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02472G, PaperAleksandra Narczyk, Sebastian Stecko The synthesis of α-aryl- and α-alkyl-substituted serine derivatives via [3,3]-sigmatropic rearrangement of allyl carbamates as a key step is reported. Allyl carbamates were obtained from the corresponding allyl alcohols. The... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 21, 2020 Category: Molecular Biology Authors: Aleksandra Narczyk Source Type: research

Substituent-controlled chemoselective synthesis of multi-substituted pyridones via a one-pot three-component cascade reaction
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02456E, PaperShitao Liu, Jisen Li, Junjie Lin, Fujun Liu, Teng Liu, Chao Huang A substituent-controlled chemoselective cycloaddition reaction which afforded a variety of 2-pyridones and 4-pyridones in good to excellent yields, respectively, has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 20, 2020 Category: Molecular Biology Authors: Shitao Liu Source Type: research

Looking at the big picture in activation strain model/energy decomposition analysis: the case of the ortho –para regioselectivity rule in Diels–Alder reactions
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02671A, PaperNicol ás Grimblat, Ariel M. Sarotti The regioselectivity of the DA reaction is predicted by theortho –para rule which has been explained from FMO theory. Using DFT calculations and ASM/EDA, we found that the results vary depending the position where it is performed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2020 Category: Molecular Biology Authors: Nicol ás Grimblat Source Type: research