Concise and collective total syntheses of 2,4-disubstituted furan-derived natural products from hydroxyoxetanyl ketones
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01924A, PaperShubhranshu Shekhar Sahoo, Priyanka Kataria, Ravindar Kontham The furan moiety, prevalent in bioactive natural products and essential drugs, presents intriguing structural features that have spurred our exploration into streamlined chemical synthesis routes for related natural products. In... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2024 Category: Molecular Biology Authors: Shubhranshu Shekhar Sahoo Source Type: research

A comparative study of two aldehyde dehydrogenases from Sphingobium sp.: the substrate spectrum and catalytic mechanism
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB01937C, PaperSiyi Chen, Jieyu Zhou, Xiangyuan Gu, Ye Ni SpALDH1 andSpALDH2 fromSphingobium sp. SYK-6 exhibit distinct enzymatic properties. Computational simulation reveals that the different substrate specificity could be attributed to the hydrophobicity of substrate binding pockets. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 23, 2024 Category: Molecular Biology Authors: Siyi Chen Source Type: research

Dual functional profluorescent nitroxides for the detection of reactive oxygen species and inhibition of collagen degradation during reassembly
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB01667F, PaperNattawut Decha, Jutakan Thonglam, Jirut Meesane, Soraya Pornsuwan, Chittreeya Tansakul Dual functional profluorescent nitroxide probes efficiently detect ROS and inhibit collagen degradation in a single operation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 22, 2024 Category: Molecular Biology Authors: Nattawut Decha Source Type: research

Visible-light photocatalyzed C –N bond activation of tertiary amines: a three-component approach to synthesize quinazolines
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB02067C, PaperAjithkumar Arumugam, Gopal Chandru Senadi A metal-free three-component carbon synthon approach has been developed to prepare 2,4-disubstituted quinazolines fromo-acylanilines, trialkylamines and ammonium chloride under visible-light using eosin Y as the photocatalyst with broad scope. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 22, 2024 Category: Molecular Biology Authors: Ajithkumar Arumugam Source Type: research

Synthesis of 6,8-diaminopurines via Acid-induced Cascade Cyclization of 5-Aminoimidazole Precursors and Preliminary Anticancer Evaluation
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01985C, PaperN ádia R. Senhorães, Bruna F. Silva, Raquel Sousa, Bruna P. Leite, Jorge M. Gonçalves, Filipe Alexandre Almeida Paz, Cristina Pereira-Wilson, Alice Dias Inspired by the pharmacological interest of 6-substituted purine roscovitine for cancer treatment, 5-aminoimidazole-4-carboxamidine precursors containing a cyanamide unit were prepared by condensation of 5-amino-4-cyanoformimidoylimidazoles with a wide range of primary... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 22, 2024 Category: Molecular Biology Authors: N ádia R. Senhorães Source Type: research

Decarboxylative [3+2] Cycloaddition of Propargyl Cyclic Carbonates/Carbamates as C2 Synthons with C,O-bis(nucleophile)s for the generation of Dihydrofuro[3,2-c]coumarins and Dihydronaphtho[1,2-b]furans with All-Carbon Quaternary Center
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01893H, PaperShravani Battula, Pranay Kothuri, Haripriya Bhumannagari, Kiranmai Nayani The development of efficient and straight forward strategies for obtaining chiral complex molecules from readily available starting materials is of great value in drug discovery. The stereodivergent synthesis of heterocycles... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 20, 2024 Category: Molecular Biology Authors: Shravani Battula Source Type: research

Visible-Light-Induced Synthesis of 2,4-Disubstituted Quinolines from o-Vinylaryl Isocyanides and Oxime Esters
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB02060F, PaperYu Liu, Chuan Ding, Jia-Jing Huang, Quan Zhou, Biquan Xiong, Kewen Tang, Peng-Fei Huang A visible-light-induced radical cyclization reaction of o-vinylaryl isocyanides and oxime esters to access various 2,4-disubstituted quinolines was disclosed. Oxime esters were employed as acyl radical precursors via the carbon −carbon bond... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 20, 2024 Category: Molecular Biology Authors: Yu Liu Source Type: research

Anionic photochemical rearrangement of 3-hydroxypyran-4-ones bearing oxazol-2-one fragment
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01957H, PaperAndrey N. Komogortsev, Valeriya Melekhina, Boris Lichitskii Photochemical behavior of in situ generated anions of 3-hydroxypyran-4-ones containing oxazol-2-one moiety was studied. For the first time it was demonstrated that blue LED light irradiation (450 nm) of substituted... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 20, 2024 Category: Molecular Biology Authors: Andrey N. Komogortsev Source Type: research

Synthesis of 4-(Trichloromethyl)pyrido[2',1':3,4]pyrazino[2,1-b]quinazolinones through a Cyclized Dearomatization and Tri-chloromethylation Cascade Strategy
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB02084C, CommunicationXu Zhang, Meng-Yan Wei, Jun-Cheng Su, Cui Liang, Chengxue Pan, Gui-Fa Su, Dong-Liang Mo A variety of 4-(trichloromethyl)pyrido[2',1':3,4]pyrazino[2,1-b]quinazolinones were prepared in moderate to good yields with high regioselectivity through intramolecular 6-endo-dig cyclization and trichloromethylation of N3-alkynyl-2-pyridinyl tethered quinazolinones in chloroform. Mechanistic studies revealed that... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 19, 2024 Category: Molecular Biology Authors: Xu Zhang Source Type: research

Synthesis of 2-benzyl benzoxazoles and benzothiazoles via elemental sulfur promoted cyclization of styrenes with 2-nitrophenols and N,N-dialkyl-3-nitroanilines
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB01775C, PaperTruong K. Chau, Nguyen T. Ho, Tuan H. Ho, Anh T. Nguyen, Khoa D. Nguyen, Nam T. S. Phan, Ha V. Le, Tung T. Nguyen Annulation of 2-nitrophenols andN,N-dialkyl-3-nitroanilines with styrenes in the presence of elemental sulfur and the base DABCO successfully yielded 2-benzyl benzoxazoles and 2-benzyl benzothiazoles, respectively. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 19, 2024 Category: Molecular Biology Authors: Truong K. Chau Source Type: research

Stereoselective Synthesis of Thailandamide A Methyl Ester
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB02107F, PaperHimangshu Sharma, Swapnamoy Ganguly, Moinul Haque Sahana, Rajib Kumar Goswami A convergent strategy for the stereoselective synthesis of the methyl ester of structurally challenging and highly labile antibacterial polyene polyketide natural product thailandamide A has been developed. The key steps... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 19, 2024 Category: Molecular Biology Authors: Himangshu Sharma Source Type: research

The Michael Donor-Acceptor Reactivity of Curcumins in the Synthesis of Diverse Multi-functional Scaffolds
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01734F, Review ArticleBanamali Laha, Abhishek R. Tiwari, Edmond Gravel, Eric Doris, Irishi N Namboothiri Curcumin is a key constituent of turmeric with a variety of biological activities. From a chemical point of view, curcumin contains different functional groups that can undergo multiple transformations such... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 18, 2024 Category: Molecular Biology Authors: Banamali Laha Source Type: research

Synthesis and applications of symmetric amino acid derivatives
Org. Biomol. Chem., 2024,22,411-428 DOI: 10.1039/D3OB01379K, Review ArticleChihiro Tsukano, Ayumi Uchino, Kazuhiro Irie This review describes the synthesis of symmetrical amino acid derivatives, classified by their structures and synthetic strategies. Applications of these amino acids are also described. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2024 Category: Molecular Biology Authors: Chihiro Tsukano Source Type: research

Phenolylazoindole scaffold for facilely synthesized and bis-functional photoswitches combining controllable fluorescence and antifungal properties using theoretical methods
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB01751F, PaperHaoran Hu, Yu Liu, Junqi Li, Chong Zhang, Chao Gao, Chengguo Sun, Yang Du, Bingcheng Hu Novel phenolylazoindole photoswitch derivatives can be facilely modified as functional molecules with stationary photoswitching properties. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2024 Category: Molecular Biology Authors: Haoran Hu Source Type: research

Alcohol synthesis based on the SN2 reactions of alkyl halides with the squarate dianion
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Kazuto Sato, Tomoyuki Fujita, Takashi Takeuchi, Takahiro Suzuki, Kazutada Ikeuchi, Keiji Tanino We developed a convenient method for transforming alkyl halides into the corresponding alcohols through an SN2 reaction using the squarate anion, prepared from squaric acid and a base, followed by a one-pot hydrolysis of the resulting squaric esters. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 17, 2024 Category: Molecular Biology Authors: Kazuto Sato Source Type: research