Selective C-H Sulfenylation of Thiazoles via Thiazol-2-yl-phosphonium Salts
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00684J, PaperYou Zi, Konrad Wagner, Fritz Sch ömberg, Ivan Vilotijevic Thiazoles and benzothiazoles undergo regioselective C2-H chalcogenation via the sequence of thiazole C2-functionalization with phosphines to produce phosphonium salts which in turn react with S- and Se-centered nucleophiles to give... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2020 Category: Molecular Biology Authors: You Zi Source Type: research

Guanidyl modification of the 1-azabicyclo[3.1.0]hexane ring in ficellomycin essential for its biological activity
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00339E, PaperSumire Kurosawa, Kenichi Matsuda, Fumihito Hasebe, Taro Shiraishi, Kazuo Shin-ya, Tomohisa Kuzuyama, Makoto Nishiyama The 1-Azabicyclo[3.1.0]hexane ring is a key moiety in the natural products for biological activities against bacteria, fungi, and tumor through DNA alkylation. Ficellomycin is a dipeptide that consists ofL-valine... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2020 Category: Molecular Biology Authors: Sumire Kurosawa Source Type: research

New Inhibitors for the BPTF Bromodomain Enabled by Structural Biology and Biophysical Assay Development
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00506A, PaperPeter D. Ycas, Huda Zahid, Alice Chan, Noelle Olson, Jorden A. Johnson, Siva Talluri, Ernst Sch önbrunn, William Pomerantz Bromodomain-containing proteins regulate transcription through protein-protein interactions with chromatin and serve as scaffolding proteins for recruiting essential members of the transcriptional machinery. One such protein is the bromodomain and PHD-containing... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2020 Category: Molecular Biology Authors: Peter D. Ycas Source Type: research

Palladium-Catalyzed Synthesis of 5-Amino-1,2,4-oxadiazoles via Isocyanide Insertion
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01092H, CommunicationXu Wang, Jin-Ping Fu, Jia-Xing Xie, Qing-hu Teng, Hai-Tao Tang, Ying-Ming Pan A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 18, 2020 Category: Molecular Biology Authors: Xu Wang Source Type: research

Sulfur-Mediated Synthesis of Unsymmetrically Substituted N-Aryl Oxalamides by the Cascade Thioamidation/Cyclocondensation and Hydrolysis Reaction
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00811G, PaperTatyana A. Tikhonova, Nikita V. Ilment, Konstantin A. Lyssenko, Igor V. Zavarzin, Yulia Volkova A facile and straightforward synthesis of unsymmetrically substituted N-aryl oxalamides from 2,2'-biphenyldiamines, 2-chloroacetic acid derivatives, elemental sulfur, and water has been developed. This protocol is distinguished by efficiency in water... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2020 Category: Molecular Biology Authors: Tatyana A. Tikhonova Source Type: research

Cu-Catalyzed tandem N-arylation of phthalhydrazides with cyclic iodoniums to yield dihydrobenzo[c]cinnolines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00894J, PaperRongrong Xie, Hongxu Lv, Xiuqing Ye, Xiangfei Kong, Shiqing Li Cu-Catalyzed tandemN-arylation of dihydrazides with cyclic iodoniums to yield dihydrobenzo[c]cinnolines has been reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2020 Category: Molecular Biology Authors: Rongrong Xie Source Type: research

Copper-catalyzed 1,3-aminothiocyanation of arylcylcopropanes
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01060J, CommunicationXiaomin Wang, Lihong Wang, Shengbiao Yang, Linli Zhang, Yan Li, Qian Zhang A copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes with N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl isothiocyanate (TMSNCS) have been developed for the first time, efficiently synthesizing a series of γ-aminothiocyanate derivatives in moderate to excellent... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2020 Category: Molecular Biology Authors: Xiaomin Wang Source Type: research

C4-C5 Fused pyrazol-3-amines: When the degree of unsaturation and electronic characteristics of the fused ring controls regioselectivity in Ullman and Acylation reactions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00796J, PaperElisabeth Bou-Petit, Arnau Plans, Nieves Rodr íguez-Picazo, Antoni Torres-Coll, Cristina Puigjaner, Mercè Font-Bardía, Jordi Teixidó, Santiago Ramon y Cajal, Roger Estrada-Tejedor, Jose I. Borrell Pyrazol-3-amine is a scaffold present in a large number of compounds with a wide range of biological activities and, in many cases, such heterocycle is C4-C5 fused to a second... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2020 Category: Molecular Biology Authors: Elisabeth Bou-Petit Source Type: research

Modular and scalable synthesis of nematode pheromone ascarosides: implications in eliciting plant defenses
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00652A, PaperShuai Ning, Lei Zhang, Jinjin Ma, Lan Chen, Guangyao Zeng, Chao Yang, Ying-jun Zhou, Xiaoli Guo, Xu Deng A highly efficient and modular synthesis of nematode pheromone ascarosides was developed, which highlights a 4-step scalable synthesis of the common intermediate 10 in 23% yield from commercially available L-rhamnose... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 17, 2020 Category: Molecular Biology Authors: Shuai Ning Source Type: research

The synthesis and applications of porphyrin-containing pillararenes
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00763C, Review ArticleHuacheng Zhang, Jie Han Recent progress regarding the combination of porphyrins and pillararenes into hybrid compounds and supramolecular systems is summarized in this review. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Huacheng Zhang Source Type: research

Synthesis of Oligosaccharides of the Linkage Region of Proteoglycans using Regioselective Glycosylation.
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00783H, PaperH élène Ledru, Benjamin Ayela, Sylvie Fournel-Gigleux, Sandrine Gulberti, Chrystel Lopin-Bon Proteoglycans (PGs) are complex macromolecules that are composed of glycosaminoglycan (GAG) chains covalently attached to a core protein through a tetrasaccharide linker. Biosynthesis of PGs is complex and involves a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: H élène Ledru Source Type: research

Nitroepoxide ring opening with thionucleophiles in water: Synthesis of α-xanthyl ketones, β-ketosulfones and β-ketosulfonic acids
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00941E, PaperElham Badali, Hossein Rahimzadeh, Ali Sharifi, Azizollah Habibi, Azim Ziyaei Halimehjani Nitroepoxide ring opening with thionucleophiles such as potassium xanthates, sodium aryl sulfinates and sodium bisulfite in water is investigated. It provides a direct and green route for the synthesis of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Elham Badali Source Type: research

Outstanding Reviewers for Organic & Biomolecular Chemistry in 2019
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB90074E, Editorial We would like to take this opportunity to highlight the Outstanding Reviewers forOrganic& Biomolecular Chemistry in 2019, as selected by the editorial team for their significant contribution to the journal. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Source Type: research

Synthesis and Stereoisomerism of [n]Cyclo-2,9-phenanthrenylene Congeners Possessing Alternating E/Z- and R/S-Biaryl Linkages
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01064B, PaperYong Yang, Yuki Nanjo, Hiroyuki Isobe, Sota Sato The synthesis and cyclostereoisomerism of [n]cyclo-2,9-phenanthrenylenes ([n]CPhen2,9,n = 4, 6 and 8), possessing hybridE/Z- andR/S-biaryl linkages, were elaborated. The dimer of a phenanthrene derivative was used as... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Yong Yang Source Type: research

Total synthesis of four stereoisomers of methyl 4,8,12-trimethylpentadecanoate, major component of the sex pheromone of the stink bug Edessa meditabunda
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00862A, PaperDaiane Szczerbowski, Stefan Schulz, Paulo Zarbin The male produced sex pheromone of the stink bug Edessa meditabunda was previously identified as a mixture of the esters methyl 4,8,12-trimethylpentadecanoate (1) and methyl 4,8,12-trimethyltetradecanoate (2), produced in a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Daiane Szczerbowski Source Type: research

Solvent-free, under air selective synthesis of α-glycosides adopting glycosyl chlorides as the donors
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01024C, PaperSerena Traboni, Giulia Vessella, Emiliano Bedini, Alfonso Iadonisi α-glycosides are highly relevant synthetic targets due to their abundance in natural oligosaccharides involved in many biological processes. Nevertheless their preparation is hampered by several issues, due to both the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Serena Traboni Source Type: research

Design of potent ABA receptor antagonists based on a conformational restriction approach
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01017K, PaperJun Takeuchi, Hikaru Nagamiya, Sayaka Moroi, Toshiyuki Ohnishi, Yasushi Todoroki The physiological functions of the plant hormone abscisic acid (ABA) are triggered by interactions between PYR/PYL/RCAR receptors (PYLs) and group-A protein phosphatases 2C (PP2Cs). PYL agonists/antagonists capable of inducing/disrupting these... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Jun Takeuchi Source Type: research

Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00588F, CommunicationYifeng Wang, Zhenhui Jiang, Mingming Chu, SuoSuo Qi, Hao Yin, Hong-Te Han, Dan-Qian Xu A highly enantioselective homogeneous fluorination of cyclic β-keto esters catalyzed by diphenylamine linked bis(oxazoline)-Cu(OTf)2 complexes has been established in a continuous flow microreactor. The microreactor allowed an efficient transformation with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 16, 2020 Category: Molecular Biology Authors: Yifeng Wang Source Type: research

Copper-catalyzed ortho-C(sp2) –H amination of benzamides and picolinamides with alkylamines using oxygen as a green oxidant
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00784F, PaperQiong Li, Jie Huang, Gong Chen, Shui-Bo Wang A versatile Cu-catalyzed directortho-C(sp2) –H amination of benzamides and picolinamides with alkylamines has been achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2020 Category: Molecular Biology Authors: Qiong Li Source Type: research

Light-induced one-pot synthesis of pyrimidine derivatives from vinyl azides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00693A, PaperTuan K. Nguyen, Gleb D. Titov, Olesya V. Khoroshilova, Mikhail A. Kinzhalov, Nikolai V. Rostovskii A one-pot procedure for the synthesis of tetrasubstituted dihydropyrimidine and pyrimidine derivatives from α-azidocinnamates was developed. The synthesis is based on the finding that the outcome of LED photolysis of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 15, 2020 Category: Molecular Biology Authors: Tuan K. Nguyen Source Type: research

Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01084G, PaperAurea Rivas, Raquel Pequerul, Vito Barracco, Marta Dom ínguez, Susana López, Rafael Jiménez, Xavier Parés, Rosana Alvarez, Jaume Farrés, Angel R. de Lera Human aldo-keto reductases (AKRs) are enzymes involved in the reduction, among other substrates, of all-trans-retinal to all-trans-retinol (vitamin A), thus contributing to the control of the levels of retinoids in organisms. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society o...
Source: RSC - Organic and Biomolecular Chemistry - June 13, 2020 Category: Molecular Biology Authors: Aurea Rivas Source Type: research

Practical Direct Synthesis of N-Aryl-Substituted Azacycles from N-Alkyl Protected Arylamines Using TiCl4 and DBU
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00880J, PaperVan Hieu Tran, Minh Thanh La, Soosung Kang, Hee-Kwon Kim Novel transformation ofN-alkyl protected arylamines and cyclic ethers toN-aryl substituted azacycles is described. Alkyl groups have been used for protection of amines in organic syntheses. In this synthesis,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 13, 2020 Category: Molecular Biology Authors: Van Hieu Tran Source Type: research

Selective N-Monomethylation of Primary Anilines with the Controllable Installation of N-CH2D, N-CHD2, and N-CD3 Units
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01054E, CommunicationJing Meng, Hui-Min Xia, Ai-Qing Xu, Yi-Feng Wang, Zhijuan Wang, Feng-Lian Zhang Selective N-monomethylation of primary anilines was realized by the employment of Me3N-BH3/N,N-Dimethylformamide (DMF) system as the methyl source. This method also allows for the selective introduction of N-CDH2 and N-CD2H... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 13, 2020 Category: Molecular Biology Authors: Jing Meng Source Type: research

Recent advances in the oxime-participating synthesis of isoxazolines
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00963F, Review ArticleJianhua Liao, Lu Ouyang, Qi Jin, Jian Zhang, Renshi Luo This review is devoted to highlighting the main achievements in the development of methodologies for the synthesis of isoxazolines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 11, 2020 Category: Molecular Biology Authors: Jianhua Liao Source Type: research

Tuning activation and self-immolative properties of the bioorthogonal alkene –azide click-and-release strategy
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00936A, PaperJessica M. Fairhall, Madoka Murayasu, Sumit Dadhwal, Sarah Hook, Allan B. Gamble Combinations of aryl azides andtrans-cyclooctenes have been studied in a bioorthogonal click-and-release strategy, with two reaction pairings rapidly releasing phenol at micromolar concentrations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 11, 2020 Category: Molecular Biology Authors: Jessica M. Fairhall Source Type: research

Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00781A, PaperVanessa Porkolab, Carlo Pifferi, Ieva Sutkeviciute, Stefania Ordanini, Marwa Taouai, Michel Thepaut, Corinne Viv ès, Mohammed Benazza, Anna Bernardi, Olivier Renaudet, Franck Fieschi Multivalent interactions between complex carbohydrates and oligomeric C-type lectins govern a wide range of immune responses. Up to date, standard SPR (surface plasmon resonance) competitive assays have largely been to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 11, 2020 Category: Molecular Biology Authors: Vanessa Porkolab Source Type: research

Synthesis of Indoles from Alkynes and a Nitrogen Source under Metal-Free Conditions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00670J, Review ArticleJose Neto, Gilson Zeni Indoles are an important nucleus of the N-heterocyles found in many natural products, active pharmaceuticals, and functional materials. In addition, indoles have various reactive positions, each one with a different... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 11, 2020 Category: Molecular Biology Authors: Jose Neto Source Type: research

Electrochemical regioselective alkylations of a [60]fulleroindoline with bulky alkyl bromides
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00876A, PaperYong Yang, Chuang Niu, Muqing Chen, Shangfeng Yang, Guan-Wu Wang Electrochemical alkylations of a [60]fulleroindoline with different bulky alkyl bromides exhibit different reaction behaviors; the major 1,4,9,12-adduct is obtained along with the minor 1,2,3,16-adduct for the bulkier diphenylbromomethane. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Yong Yang Source Type: research

Syntheses of α-CF3-α-quaternary ketones via p-quinone methides and their derivatization to compounds with successively congested stereogenic centers
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00951B, PaperKyu Terashima, Tomoko Kawasaki-Takasuka, Tomohiro Agou, Toshio Kubota, Takashi Yamazaki NHC-catalyzed 1,6-conjugate additions of a variety of aldehydes to δ-CF3- δ-substitutedp-quinone methides and their highly diastereoselective derivatization to compounds with successively congested stereogenic centers were performed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Kyu Terashima Source Type: research

Stereoselective synthesis of an eleganine A core
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00939C, CommunicationGints Smits, Ronalds Zemribo The core structure of eleganine A – a cytotoxic indole monoterpene alkaloid – was accessed for the first time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Gints Smits Source Type: research

Palladium-catalyzed C8 –H alkoxycarbonylation of 1-naphthylamines with alkyl chloroformates
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00586J, PaperYaqi Shi, Fan Yang, Yangjie Wu A simple and efficient protocol for palladium-catalyzed C8 –H alkoxycarbonylation of 1-naphthylamine derivatives with alkyl chloroformates has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Yaqi Shi Source Type: research

Rational Design of Fluorescent Probes for Targeted in vivo Nitroreductase Visualization
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00082E, CommunicationJie Gao, Xiaofan Yin, Mimi Li, Ji-An Chen, JIahui Tan, Zhen Zhao, Xianfeng Gu Nitroreductase (NTR) has been recognized as a biomarker for identifying the hypoxic status of cancers. Therefore, it is of high scientific interest to design effective fluorescent probes for tracking NTR... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Jie Gao Source Type: research

Cu-Catalyzed tandem N-arylation of phthalhydrazide with cyclic iodoniums to yield dihydrobenzo[c]cinnolines
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00894J, PaperRongrong Xie, Hongxu Lv, Xiuqing Ye, Xiangfei Kong, Shiqing Li Dihydrocinnolines have attractive pharmacological properties. Herein, we diagnose a Cu-catalyzed tandem N-arylation reaction phthalhydrazide with cyclic iodonium salts to construct dihydrobenzo[c]cinnoline derivatives. Various iodonium salts, such as symmetrical, unsymmetrical, aryl-aryl,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Rongrong Xie Source Type: research

Efficient and selective antibody modification with functionalised divinyltriazines
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Andrew James Counsell, Stephen J Walsh, Naomi Stephanie Robertson, Hannah Sore, David R Spring A highly efficient disulfide rebridging strategy for the modification of monoclonal antibodies with substituted divinyltriazine linkers is reported. The reaction proceeds efficiently under mild conditions with near stoichiometric quantities of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Andrew James Counsell Source Type: research

Picoloyl Protecting Group in Synthesis: Focus on a Highly Chemoselective Catalytic Removal
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00803F, PaperScott Geringer, Michael P. Mannino, Mithila Bandara, Alexei V Demchenko The picoloyl protecting group has proven to be a versatile protecting group in carbohydrate chemistry. It can be used for the purpose of stereocontrolling glycosylations via an H-bond-mediated Aglycone Delivery... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Scott Geringer Source Type: research

One-pot synthesis of pyrimidine linked naphthoquinone-fused pyrroles by iodine-mediated multicomponent reactions
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00591F, PaperAnoop Panday, Danish Ali, Md Lokman H. Choudhury Herein we report iodine-mediated multicomponent reactions for the synthesis of naphthoquinone-fused pyrroles tethered with pyrimidine moiety. The reaction of aryl methyl ketones (3) or terminal aryl alkynes (5) in the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Anoop Panday Source Type: research

A 19F-MRI probe for the detection of Fe(II) ions in an aqueous system
This study outlines the development of F-Nox-1 as the first example... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Ryo Kakiuchi Source Type: research

Copper-catalyzed ortho-C(sp2)-H amination of benzamides and picolinamides with alkylamines using oxygen as green oxidant
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00784F, PaperQiong Li, Jie Huang, Gong Chen, Shu-Bo Wang A versatile Cu/O2 catalyzed direct Ortho-C(sp2)-H amination of benzamides and picolinamides with alkylamines has been achieved. This method employs cheap and eco-friendly copper as a catalyst and oxygen as an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Qiong Li Source Type: research

Red-shifted backbone N –H photocaging agents
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00923G, CommunicationAlicia E. Mangubat-Medina, Hallie O. Trial, Reyner D. Vargas, Mekedlawit T. Setegne, Taysir Bader, Mark D. Distefano, Zachary Thomas Ball Light is a uniquely powerful tool for spatiotemporal control of molecular structure, necessitating the development of new photocaging approaches. This communication describes the design, synthesis, and reactivity of two new... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Alicia E. Mangubat-Medina Source Type: research

Efficient copper(I)-catalyzed oxidative intermolecular 1,2-estersulfenylation of styrenes with peroxyesters and disulfides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00823K, PaperYiting Luo, Rongkui Su, Hongming Yang A simple and practical method for the synthesis of thio-substituted esters through copper(I)-catalyzed intermolecular 1,2-estersulfenylation of styrenes with peroxyesters and disulfides was developed. In this transformation, two new C-S bond... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Yiting Luo Source Type: research

A [Pd2L4]4+ cage complex for n-octyl- β-D-glycoside recognition
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Xander Schaapkens, Eduard Bobylev, Joost N. H. Reek, Tiddo Jonathan Mooibroek The cage complex [Pd294]4+ (3 ’) bindsn-octyl glycosides in DCM/DMSO (9:1) solution withKa≈ 51 M-1 forn-Oct-β-D-Glc andKa≈ 29 M-1 forn-Oct-β-D-Gal. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Xander Schaapkens Source Type: research

A Synthetic Guide to Alkynyl Sulfides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00908C, Review ArticleShawn Collins, Jeffery Santandrea, Eric Godin The relative stability and predictable reactivity of alkynyl sulfides make them ideal synthons for the development of new transformations. Classic methods for forming alkynyl sulfides relied on dehydrohalogentaion approaches. However... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Shawn Collins Source Type: research

Recent Development in the Synthesis of C-Glycosides Involving Glycosyl Radicals
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00711K, Review ArticleLin-Yi Xu, Nai-Li Fan, Xiang-Guo Hu C-glycosylation involving glycosyl radical intermediates is a particularly effective approach to access C-glycosides, which are core units of a great number of natural products, bioactive compounds and marketed drugs. In... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 10, 2020 Category: Molecular Biology Authors: Lin-Yi Xu Source Type: research

Comparison of Disaccharide Donors for Heparan Sulfate Synthesis: Uronic Acids vs. their Pyranose Equivalents
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00671H, CommunicationDaniel Sheppard, Scott A Cameron, Peter Tyler, Ralf Schw örer Late oxidation of hexose based building blocks or the use of uronic acid containing building blocks are two complementary strategies in the synthesis of glycosaminoglycans, the latter simplifiying the later... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 9, 2020 Category: Molecular Biology Authors: Daniel Sheppard Source Type: research

Synthesis and practical applications of 2-(2-nitroalkyl)pyrroles
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00956C, Review ArticleAlessandro Palmieri, Marino Petrini Two main approaches can be designed for the synthesis of 2-(2-nitroalkyl)pyrroles using nitroalkenes or nitroalkanes in the reaction with pyrrole derivatives. The obtained nitroalkyl pyrroles can be converted into various bioactive compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 8, 2020 Category: Molecular Biology Authors: Alessandro Palmieri Source Type: research

Manganese(III)-Promoted Tandem Phosphinoylation/Cyclization of 2-Arylindoles/2-Arylbenzimidazoles with Disubstituted Phosphine Oxides
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00877J, PaperShuai-Shuai Jiang, Yu-Ting Xiao, Yan-Chen Wu, Shu-Zheng Luo, Ren-Jie Song, Jin-Heng Li A simple and practical method for the synthesis of phosphoryl-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and benzimidazo[2,1-a]isoquinolin-6(5H)-ones through manganese(III)-promoted tandem phosphinoylation/cyclization of 2-arylindoles or 2-arylbenzimidazoles with disubstituted phosphine oxides was developed. In this transformation,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 8, 2020 Category: Molecular Biology Authors: Shuai-Shuai Jiang Source Type: research

Copper(II)-Catalyzed Stereoselective 1,2-Addition vs Ferrier Glycosylation of “Armed” and “Disarmed” Glycal Donors
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01042A, PaperManoj Kumar, Thurpu Raghavender Reddy, Aakanksha Gurawa, Sudhir Kashyap Selective activation of “armed’ and ‘’disarmed’’ glycal donor enabling the stereo-controlled glycosylations by employing Cu(II)-catalyst as the promoter has been realized. The distinctive stereochemical outcome in the process is mainly... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 8, 2020 Category: Molecular Biology Authors: Manoj Kumar Source Type: research

Palladium-Catalyzed C8-H Alkoxycarbonylation of 1-Naphthylamines with Alkyl Chloroformates
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00586J, PaperYaqi Shi, Fan Yang, Yangjie Wu A simple and efficient protocol for palladium-catalyzed C8-H alkoxycarbonylation of 1-naphthylamine derivatives with alkyl chloroformates has been developed, exhibiting broad functional group tolerance, high regioselectivity, and oxidant-free conditions. Furthermore, the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 5, 2020 Category: Molecular Biology Authors: Yaqi Shi Source Type: research

Synthesis of C11 ‐to‐C14 Methyl‐shifted all‐trans‐Retinal Analogues and Their Activities On Human Aldo‐Keto Reductases
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01084G, PaperAurea Rivas, Raquel Pequerul, Vito Barracco, Marta Dominguez Seoane, Susana L ópez, Rafael Jiménez, Xavier Pares, Rosana Alvarez, Jaume Farres, Angel R. de LERA The human aldo-keto reductases (AKRs) are enzymes involved in the reduction, among other substrates, of all-trans-retinal to all-trans-retinol (vitamin A), thus contributing to the control of the levels of retinoids... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 5, 2020 Category: Molecular Biology Authors: Aurea Rivas Source Type: research

Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes.
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01052A, PaperDale C Guenther, Raymond Emehiser, Allison Inskeep, Saswata Karmakar, Patrick J. Hrdlicka Invader probes, i.e., DNA duplexes modified with +1 interstrand zippers of intercalator-functionalized nucleotides like 2'-O-(pyren-1-yl)methyl-RNA monomers, are energetically activated for sequence-unrestricted recognition of double-stranded DNA (dsDNA) as they are engineered... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 5, 2020 Category: Molecular Biology Authors: Dale C Guenther Source Type: research