Identification of BACE-1 inhibitors through directed C(sp3) –H activation on 5-oxo-pyrrolidine-3-carboxylic acid derivatives

This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Lorenzo Baldini, Elena Lenci, Cristina Faggi, Andrea Trabocchi Stereochemically dense 5-oxo-pyrrolidines were obtained by combining the Castagnoli –Cushman reaction with directed Pd-catalyzed C(sp3) –H functionalization and enabling the identification of two BACE-1 enzyme inhibitors with sub-micromolar activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research