Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples
This study was conducted to assess the purity and label accuracy of commercially available CBD products.Methods: Commercially available CBD products were chosen from the open stream of commerce in the United States based on formulations as a tincture, gummy, vape, or topical product. Cannabinoid concentrations were analyzed to verify label accuracy including “full spectrum,” “broad spectrum,” and “CBD isolate” claims on the product label. Analysis for the presence of contaminants included evaluation for heavy metals, pesticides, and residual solvents. Labeled and actual total amounts of CBD and levels of impuri...
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Assessment of the implementation of accelerated drug marketing registration procedures for antineoplastic and immunomodulating agents in China: based on 2016 –2022 review data
Conclusion:ADMRPs can promote the accessibility of antineoplastic and immunomodulating agents in China and safeguard the life and health rights of more patients. Nevertheless, it is necessary to pay attention to the expansion of the types of indications for medicines and to increase the development of drugs that are urgently needed by a small number of patients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients
Conclusion:The first combination of PPK and machine learning for predictive modeling of vancomycin clearance in adult patients. It provides a reference for clinical pharmacists or clinicians to optimize the initial dosage given to ensure the effectiveness and safety of drug therapy for each patient. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Examining the safety of mirabegron: an analysis of real-world pharmacovigilance data from the US FDA adverse event reporting system (FAERS) database
Conclusion: This study provided valuable evidence for the real-world safety of mirabegron, helping clinical professionals enhance their understanding of mirabegron’s safety in clinical practice. It also contributed valuable evidence for further safety studies on mirabegron. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway
In conclusion, our results indicate that IQC protects the changes in mitochondrial membrane permeability in cardiomyocytes by regulating the Phlpp1/AKT/Bcl-2 signaling pathway, inhibits the release of cytc from the mitochondrial inner membrane to the cytoplasm, forms apoptotic bodies, induces cell apoptosis, and reduces THP induced cardiotoxicity. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

History and future perspectives of adipose tissue macrophage biology
Macrophages contribute to adipose tissue homeostasis; however, they are also thought to be responsible for insulin resistance in obesity. Macrophages, which were oversimplified in past methodologies, have become rather difficult to understand comprehensively as recent developments in research methodology have revealed their diversity. This review highlights recent studies on adipose tissue macrophages, identifies controversial issues that need to be resolved and proposes a scenario for further development of adipose tissue macrophage biology. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

PCC0208057 as a small molecule inhibitor of TRPC6 in the treatment of prostate cancer
Prostate cancer (PCa) is a common malignant tumor, whose morbidity and mortality keep the top three in the male-related tumors in developed countries. Abnormal ion channels, such as transient receptor potential canonical 6 (TRPC6), are reported to be involved in the carcinogenesis and progress of prostate cancer and have become potential drug targets against prostate cancer. Here, we report a novel small molecule inhibitor of TRPC6, designated as PCC0208057, which can suppress the proliferation and migration of prostate cancer cells in vitro, and inhibit the formation of Human umbilical vein endothelial cells cell lumen. P...
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Modifying platelets at their birth: anti-thrombotic therapy without haemorrhage
Cardiovascular disease is a leading cause of death. The current approach to the prevention of arterial thrombosis in cardiovascular disease is dependent on the use of therapies which inhibit the activation of platelets. Predictably these are associated with an increased risk of haemorrhage which causes significant morbidity. The thrombotic potential of an activated platelet is modifiable; being determined before thrombopoiesis. Increased megakaryocyte ploidy is associated with larger and more active platelets carrying an increased risk of thrombosis. The reduction in the ploidy of megakaryocytes is therefore a novel area o...
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Long-term benefits of EPs ® 7630 in patients with acute sinusitis: a real-world cohort study
Conclusion: EPs® 7630 prescription is associated with long-term benefits in AS patients. EPs® 7630 can help to reduce inappropriate antibiotic use and might reduce the risk of chronic sinusitis or nasal polyps. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Effects and safety of Ginkgo biloba on depression: a systematic review and meta-analysis
Conclusion: In conclusion, the main finding was that patients treated with GKB had better MBI, MESSS, BDNF, 5-HT, and HAMD values after 4 weeks, 6 weeks, and 8 weeks than the control group. GKB might reduce the risk of depression or depressive symptoms with safe clinical efficacy.Systematic Review Registration: identifier (INPLASY2023100052) (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Traditional Tibetan medicine: therapeutic potential in lung diseases
Lung diseases have become a major threat to human health worldwide. Despite advances in treatment and intervention in recent years, effective drugs are still lacking for many lung diseases. As a traditional natural medicine, Tibetan medicine has had a long history of medicinal use in ethnic minority areas, and from ancient times to the present, it has a good effect on the treatment of lung diseases and has attracted more and more attention. In this review, a total of 586 Tibetan medicines were compiled through literature research of 25 classical works on Tibetan medicine, drug standards, and some Chinese and English databa...
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future
Phase 0 microdosing studies were introduced to the drug development community approximately 20 years ago. A microdose is defined as less than 1/100th of the dose calculated based on animal data to yield a pharmacological effect in humans, with a maximum of 100 μg, or 30 nmoles for protein products. In our experience, Phase 0 microdose studies have not been fully embraced by the pharmaceutical industry. This notion is based on the number of Phase 0 studies that we have been involved in. Thus, we conducted at least 17 Phase 0 microdose studies in the Zero’s (on average, two per year), but in the years beyond this, it ...
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota
Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for...
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research

Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database
Conclusion:Our research findings align with established results, affirming the favorable safety profile of cenobamate. Effective prevention of adverse reactions induced by cenobamate can be achieved through the establishment of efficient blood concentration monitoring and dose adjustments. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Source Type: research

Corrigendum: Patchouli alcohol improved diarrhea-predominant irritable bowel syndrome by regulating excitatory neurotransmission in the myenteric plexus of rats
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Source Type: research