Corrigendum: Comparison of the effectiveness and safety of perampanel and oxcarbazepine as monotherapy in children and adolescents with newly diagnosed focal epilepsy
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Recent advances in medicinal compounds related to corneal crosslinking
Corneal crosslinking (CXL) is the recognized technique to strengthen corneal collagen fibers through photodynamic reaction, aiming to halt progressive and irregular changes in corneal shape. CXL has greatly changed the treatment for keratoconus (KCN) since it was introduced in the late 1990’s. Numerous improvements of CXL have been made during its developing course of more than 20 years. CXL involves quite a lot of materials, including crosslinking agents, enhancers, and supplements. A general summary of existing common crosslinking agents, enhancers, and supplements helps give a more comprehensive picture of CXL. Eithe...
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria
Discussion: GL-PP inhibits intrarenal PRR/sPRR-RAS activation and upregulation of NOX4 and H2O2, suggesting potential therapeutic approaches against DOX-induced nephropathy. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Corrigendum: Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
A study on the preparation conditions of lidocaine microemulsion based on multi-objective genetic algorithm
Conclusion: Two lidocaine microemulsion preparation protocols were proposed in this study. These preparations resulted in good transdermal performance or long anesthesia duration, respectively. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties
Conclusion: Our findings highlight the potential for further development of ZK002 as a dual function therapeutic against diseases with involvement of pathogenic angiogenesis and chronic inflammation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Distinct pleiotropic effects of direct oral anticoagulants on cultured endothelial cells: a comprehensive review
Direct Oral Anticoagulants (DOACs) have simplified the treatment of thromboembolic disease. In addition to their established anticoagulant effects, there are indications from clinical and preclinical studies that DOACs exhibit also non-anticoagulant actions, such as anti-inflammatory and anti-oxidant actions, advocating overall cardiovascular protection. In the present study, we provide a comprehensive overview of the existing knowledge on the pleiotropic effects of DOACs on endothelial cells (ECs) in vitro and their underlying mechanisms, while also identifying potential differences among DOACs. DOACs exhibit pleiotropic ...
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of traditional Chinese medicine adjuvant therapy for severe pneumonia: evidence mapping of the randomized controlled trials, systematic reviews, and meta-analyses
Conclusion: TCM combined with conventional treatment had advantages in efficacy, clinical signs, laboratory results, and life quality outcomes of severe pneumonia, with no difference in safety outcomes compared with conventional treatment only. QingJin Huatan decoction is the most promising target, and Xuanbai Chengqi decoction has a “Probably beneficial” conclusion. XueBiJing injection and TanReQing injection are two commonly used Chinese herbal injections for treating severe pneumonia, and both are “Probably beneficial.” However, there was a need for multicenter RCTs with large sample sizes and high methodologica...
Source: Frontiers in Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Source Type: research
Corrigendum: Commentary: An evaluation of traditional Persian medicine for the management of SARS-CoV-2
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments
Herbal medicines are becoming increasingly popular among patients because they are well tolerated and do not exert severe side effects. Nevertheless, they receive little consideration in therapeutic settings. The present article reviews the current state of research on the clinical benefits of herbal medicines on five indication groups, psychosomatic disorders, gynecological complaints, gastrointestinal disorders, urinary and upper respiratory tract infections. The study search was based on the database PubMed and concentrated on herbal medicines legally approved in Europe. After applying defined inclusion and exclusion cr...
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
Lipid metabolism as a target for cancer drug resistance: progress and prospects
Cancer is the world’s leading cause of human death today, and the treatment process of cancer is highly complex. Chemotherapy and targeted therapy are commonly used in cancer treatment, and the emergence of drug resistance is a significant problem in cancer treatment. Therefore, the mechanism of drug resistance during cancer treatment has become a hot issue in current research. A series of studies have found that lipid metabolism is closely related to cancer drug resistance. This paper details the changes of lipid metabolism in drug resistance and how lipid metabolism affects drug resistance. More importantly, most studi...
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis
Discussion: Findings from both animal and in vitro studies suggest that ursolic acid decreases inflammatory cytokine levels, elevates antioxidant enzyme levels, and reduces oxidative stress levels (graphical abstract). This meta-analysis furnishes compelling evidence for the anti-inflammatory and antioxidant properties of ursolic acid. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine
Conclusion: These preliminary results call for further experiments to establish the dose-dependent effects of harmine/DMT on serotonin receptor occupancy and cerebral metabolism. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy of traditional Chinese medicine on diabetic cardiomyopathy in animal models: a systematic review and meta-analysis
Conclusion: TCM interventions were associated with significant improvements in body weight, heart weight to body weight ratio, triglyceride and cholesterol levels, left ventricular internal dimension in systole, ejection fraction, fractional shortening and E/A ratio. The heterogeneity in the results was found to be potentially due to the type of TCM, duration of intervention, method of modeling, and animal species, as shown in subgroup analysis and meta-regression.Systematic Review Registration: identifier CRD42023402908 (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
In conclusion, by observing the effects of nicotine salts on DA release in real time in vivo, differences in the pharmacological effects of nicotine salts are revealed to better understand the mechanism underlying the regulatory effects of nicotine salts on the brain. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Source Type: research
