Log in to search using one of your social media accounts:

 

Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation
Byron Carpenter, Guillaume Lebon (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 15, 2017 Category: Drugs & Pharmacology Source Type: research

P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation
Ver ónica Latapiat, Felipe E. Rodríguez, Francisca Godoy, Felipe A. Montenegro, Nelson P. Barrera, Juan P. Huidobro-Toro (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 15, 2017 Category: Drugs & Pharmacology Source Type: research

Drug Repositioning in the Mirror of Patenting: Surveying and Mining Uncharted Territory
Hermann A. M. Mucke (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 15, 2017 Category: Drugs & Pharmacology Source Type: research

Phytochemicals and PI3K Inhibitors in Cancer —An Insight
Vasanti Suvarna, Manikanta Murahari, Tabassum Khan, Pramila Chaubey, Preeti Sangave (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Pharmacist-Led Self-management Interventions to Improve Diabetes Outcomes. A Systematic Literature Review and Meta-Analysis
Linda van Eikenhorst, Katja Taxis, Liset van Dijk, Han de Gier (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

The Evaluation of Pharmacodynamics and Pharmacokinetics of Anti-thrombin DNA Aptamer RA-36
Elena Zavyalova, Nadezhda Samoylenkova, Alexander Revishchin, Askar Turashev, Ilya Gordeychuk, Andrey Golovin, Alexey Kopylov, Galina Pavlova (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities
Sen Zhang, Jie Ma, Li Sheng, Dongming Zhang, Xiaoguang Chen, Jingzhi Yang, Dongjie Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen
Jiang-Jiang Qin, Xin Li, Wei Wang, Xiaolin Zi, Ruiwen Zhang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes
Francesco Drago, Marta Lombardi, Ilaria Prada, Martina Gabrielli, Pooja Joshi, Dan Cojoc, Julien Franck, Isabelle Fournier, Jacopo Vizioli, Claudia Verderio (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

A Combined LC-MS Metabolomics- and 16S rRNA Sequencing Platform to Assess Interactions between Herbal Medicinal Products and Human Gut Bacteria in Vitro: a Pilot Study on Willow Bark Extract
Eva-Maria Pferschy-Wenzig, Kaisa Koskinen, Christine Moissl-Eichinger, Rudolf Bauer (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells
Maria Augusta Arruda, Leigh A. Stoddart, Karolina Gherbi, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

HDAC2 and HDAC5 Up-Regulations Modulate Survivin and miR-125a-5p Expressions and Promote Hormone Therapy Resistance in Estrogen Receptor Positive Breast Cancer Cells
Wen-Tsung Huang, Yu-Hsuan Tsai, Shang-Hung Chen, Ching-Wen Kuo, Yao-Lung Kuo, Kuo-Ting Lee, Wen-Chung Chen, Pei Chih Wu, Chun-Yu Chuang, Siao Muk Cheng, Chun-Hui Lin, Euphemia Yee Leung, Yung-Chieh Chang, Chun Hei Antonio Cheung (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

Purines and Carotid Body: New Roles in Pathological Conditions
Silvia V. Conde, Emilia C. Monteiro, Joana F. Sacramento (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy
Kenji Ikemura, Shunichi Hiramatsu, Masahiro Okuda (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
Patr ícia Molz, Nadja Schröder (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGF β1/Smad-Mediated Epithelial-to-Mesenchymal Transition
Xiao-Ming Zhou, Gui-Liang Wang, Xiao-Bo Wang, Li Liu, Qin Zhang, Yan Yin, Qiu-Yue Wang, Jian Kang, Gang Hou (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection
Lorenza Bellusci, Annunziatina Laurino, Martina Sabatini, Simona Sestito, Paola Lenzi, Laura Raimondi, Simona Rapposelli, Francesca Biagioni, Francesco Fornai, Alessandra Salvetti, Leonardo Rossi, Riccardo Zucchi, Grazia Chiellini (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

In Vitro Pro-apoptotic and Anti-migratory Effects of Ficus deltoidea L. Plant Extracts on the Human Prostate Cancer Cell Lines PC3
Mohd M. M. Hanafi, Adlin Afzan, Harisun Yaakob, Ramlan Aziz, Mohamad R. Sarmidi, Jean-Luc Wolfender, Jose M. Prieto (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis
Chunxiao Miao, Yuanyuan Lv, Wanli Zhang, Xiaoping Chai, Lixing Feng, Yanfen Fang, Xuan Liu, Xiongwen Zhang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric
Sahdeo Prasad, Amit K. Tyagi, Zahid H. Siddik, Bharat B. Aggarwal (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells
Renata C. Costa de Freitas, Raul H. Bortolin, Mariana B. Lopes, Let ícia Tamborlin, Letícia Meneguello, Vivian N. Silbiger, Rosario D. C. Hirata, Mário H. Hirata, Augusto D. Luchessi, André D. Luchessi (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Molecular Mechanisms of Curcumin Renoprotection in Experimental Acute Renal Injury
Youling Fan, Hongtao Chen, Huihua Peng, Fang Huang, Jiying Zhong, Jun Zhou (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
Fiorentina Roviezzo, Antonietta Rossi, Elisabetta Caiazzo, Pierangelo Orlando, Maria A. Riemma, Valentina M. Iacono, Andrea Guarino, Armando Ialenti, Carla Cicala, Alessio Peritore, Raffaele Capasso, Vincenzo Di Marzo, Angelo A. Izzo (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Commentary: Combating Sale of Counterfeit and Falsified Medicines Online: A Losing Battle
Baobin Huang, Mingzhe Xu (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 11, 2017 Category: Drugs & Pharmacology Source Type: research

Gene Mutations as Emerging Biomarkers and Therapeutic Targets for Relapsed Acute Myeloid Leukemia
Habsah Aziz, Chow Y. Ping, Hamidah Alias, Nurul-Syakima Ab Mutalib, Rahman Jamal (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 7, 2017 Category: Drugs & Pharmacology Source Type: research

The Evaluation of Geroprotective Effects of Selected Flavonoids in Drosophila melanogaster and Caenorhabditis elegans
Ekaterina Lashmanova, Nadezhda Zemskaya, Ekaterina Proshkina, Anna Kudryavtseva, Marina Volosnikova, Elena Marusich, Sergey Leonov, Alex Zhavoronkov, Alexey Moskalev (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 7, 2017 Category: Drugs & Pharmacology Source Type: research

Enhancing the Promise of Drug Repositioning through Genetics
Jayne-Louise E. Pritchard, Tracy A. O ’Mara, Dylan M. Glubb (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 6, 2017 Category: Drugs & Pharmacology Source Type: research

The Oncopig Cancer Model as a Complementary Tool for Phenotypic Drug Discovery
Natalia V. Segatto, Mariana H. Remi ão, Kyle M. Schachtschneider, Fabiana K. Seixas, Lawrence B. Schook, Tiago Collares (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Membrane Transporters for Bilirubin and Its Conjugates: A Systematic Review
Jovana Čvorović, Sabina Passamonti (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

(+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice
Val éry L. Payen, Paolo E. Porporato, Pierre Danhier, Thibaut Vazeille, Marine C. N. M. Blackman, Bronislav H. May, Paul Niebes, Pierre Sonveaux (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 4, 2017 Category: Drugs & Pharmacology Source Type: research

Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension
Allan K. N. Alencar, Guilherme C. Montes, Eliezer J. Barreiro, Roberto T. Sudo, Gisele Zapata-Sudo (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 4, 2017 Category: Drugs & Pharmacology Source Type: research

Rolipram, a Selective Phosphodiesterase 4 Inhibitor, Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain through Inhibition of Inflammatory Cytokines in the Dorsal Root Ganglion
Hee Kee Kim, Seon-Hee Hwang, Elizabeth Oh, Salahadin Abdi (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 4, 2017 Category: Drugs & Pharmacology Source Type: research

vNN Web Server for ADMET Predictions
Patric Schyman, Ruifeng Liu, Valmik Desai, Anders Wallqvist (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 4, 2017 Category: Drugs & Pharmacology Source Type: research

Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455
Stefania Gessi, Serena Bencivenni, Enrica Battistello, Fabrizio Vincenzi, Vittoria Colotta, Daniela Catarzi, Flavia Varano, Stefania Merighi, Pier Andrea Borea, Katia Varani (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 1, 2017 Category: Drugs & Pharmacology Source Type: research

Psoralea corylifolia L. Attenuates Nonalcoholic Steatohepatitis in Juvenile Mouse
Lishan Zhou, Jianqiao Tang, Xiaoli Xiong, Hui Dong, Juan Huang, Shunchang Zhou, Lingling Zhang, Huan Qin, Suqi Yan (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 30, 2017 Category: Drugs & Pharmacology Source Type: research

ToxiM: A Toxicity Prediction Tool for Small Molecules Developed Using Machine Learning and Chemoinformatics Approaches
Ashok K. Sharma, Gopal N. Srivastava, Ankita Roy, Vineet K. Sharma (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 30, 2017 Category: Drugs & Pharmacology Source Type: research

Validation of a Case-Finding Algorithm for Identifying Patients with Non-small Cell Lung Cancer (NSCLC) in Administrative Claims Databases
Ralph M. Turner, Yen-Wen Chen, Ancilla W. Fernandes (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 30, 2017 Category: Drugs & Pharmacology Source Type: research

Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population
Napatrupron Koomdee, Jirawat Pratoomwun, Thawinee Jantararoungtong, Voralaksana Theeramoke, Wichittra Tassaneeyakul, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Siwalee Santon, Apichaya Puangpetch, Utcharee Intusoma, Therdpong Tempark, Tayard Deesudchit, Patompong Satapornpong, Anannit Visudtibhan, Chonlaphat Sukasem (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 29, 2017 Category: Drugs & Pharmacology Source Type: research

Sevoflurane Induces Exaggerated and Persistent Cognitive Decline in a Type II Diabetic Rat Model by Aggregating Hippocampal Inflammation
Dongliang Li, Lingling Liu, Liang Li, Xingang Li, Bin Huang, Changqing Zhou, Zhaohang Zhang, Chunling Wang, Ping Dong, Xiyan Zhang, Bo Yang, Li Zhang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 29, 2017 Category: Drugs & Pharmacology Source Type: research

Corrigendum: Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice
Wei Chen, Fengchun Shui, Cheng Liu, Xinbo Zhou, Wei Li, Zhibing Zheng, Wei Fu, Lili Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 28, 2017 Category: Drugs & Pharmacology Source Type: research

Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXR α and Suppresses the Expression of PXR, CAR and Their Target Genes
Rui Ning, Yunran Zhan, Shuangcheng He, Jinhua Hu, Zhu Zhu, Gang Hu, Bingfang Yan, Jian Yang, Wei Liu (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 28, 2017 Category: Drugs & Pharmacology Source Type: research

Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase Pathway
Gauhar Rehman, Muhammad Hamayun, Amjad Iqbal, Sumera Afzal Khan, Hamayoon Khan, Adeeb Shehzad, Abdul Latif Khan, Anwar Hussain, Ho-Youn Kim, Jamshaid Ahmad, Ayaz Ahmad, Abid Ali, In-Jung Lee (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 28, 2017 Category: Drugs & Pharmacology Source Type: research

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function
Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes, Ulrich M. Zanger (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 27, 2017 Category: Drugs & Pharmacology Source Type: research

The Combined Use of in Silico, in Vitro, and in Vivo Analyses to Assess Anti-cancerous Potential of a Bioactive Compound from Cyanobacterium Nostoc sp. MGL001
Niveshika, Ekta Verma, Shashank K. Maurya, Rajnikant Mishra, Arun K. Mishra (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 27, 2017 Category: Drugs & Pharmacology Source Type: research

Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells
G. R. Sharath Babu, Tamatam Anand, N. Ilaiyaraja, Farhath Khanum, N. Gopalan (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 27, 2017 Category: Drugs & Pharmacology Source Type: research

Blueberry Phenolics Reduce Gastrointestinal Infection of Patients with Cerebral Venous Thrombosis by Improving Depressant-Induced Autoimmune Disorder via miR-155-Mediated Brain-Derived Neurotrophic Factor
Ning Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Donghuan Zhang, Honglei Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 27, 2017 Category: Drugs & Pharmacology Source Type: research

Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders
Marco Tozzi, Ivana Novak (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Source Type: research

If Channel as an Emerging Therapeutic Target for Cardiovascular Diseases: A Review of Current Evidence and Controversies
Hayelom G. Mengesha, Tadesse B. Tafesse, Mohammed H. Bule (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Source Type: research

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1
Jessica M ühlhaus, Juliane Dinter, Sabine Jyrch, Alexander Teumer, Simon F. Jacobi, Georg Homuth, Peter Kühnen, Susanna Wiegand, Annette Grüters, Henry Völzke, Klemens Raile, Gunnar Kleinau, Heiko Krude, Heike Biebermann (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Source Type: research

Vitamin D Enhances Efficacy of Oral Nifedipine in Treating Preeclampsia with Severe Features: A Double Blinded, Placebo-Controlled and Randomized Clinical Trial
Dan-Dan Shi, Yong Wang, Jun-Jun Guo, Ling Zhou, Na Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Source Type: research