Circulating tumor DNA: a noninvasive biomarker for tracking ovarian cancer
Reprod Biol Endocrinol. 2021 Dec 3;19(1):178. doi: 10.1186/s12958-021-00860-8.ABSTRACTOvarian cancer is the fifth leading cause of cancer-related mortality in women worldwide. Despite the development of technologies over decades to improve the diagnosis and treatment of patients with ovarian cancer, the survival rate remains dismal, mainly because most patients are diagnosed at a late stage. Traditional treatment methods and biomarkers such as cancer antigen-125 as a cancer screening tool lack specificity and cannot offer personalized combinatorial therapy schemes. Circulating tumor DNA (ctDNA) is a promising biomarker for...
Source: Reproductive Biology - December 4, 2021 Category: Reproduction Medicine Authors: Fang Yang Jun Tang Zihao Zhao Chunling Zhao Yuancai Xiang Source Type: research

Circulating tumor DNA: a noninvasive biomarker for tracking ovarian cancer
Reprod Biol Endocrinol. 2021 Dec 3;19(1):178. doi: 10.1186/s12958-021-00860-8.ABSTRACTOvarian cancer is the fifth leading cause of cancer-related mortality in women worldwide. Despite the development of technologies over decades to improve the diagnosis and treatment of patients with ovarian cancer, the survival rate remains dismal, mainly because most patients are diagnosed at a late stage. Traditional treatment methods and biomarkers such as cancer antigen-125 as a cancer screening tool lack specificity and cannot offer personalized combinatorial therapy schemes. Circulating tumor DNA (ctDNA) is a promising biomarker for...
Source: Reproductive Biology - December 4, 2021 Category: Reproduction Medicine Authors: Fang Yang Jun Tang Zihao Zhao Chunling Zhao Yuancai Xiang Source Type: research

Impact of urinary incontinence on quality of life in female CrossFit practitioners: A cross-sectional study
CONCLUSIONS: Women who had higher scores on the ICIQ-SF reported greater impact on QoL, and the previous history of two or more gestations and sexual dysfunction/pelvic organ prolapse increase the risk of women with UI who practice CrossFit to have a greater impact on QoL. Multigravida and women with sexual dysfunction/pelvic organ prolapse who practice CrossFit could have more attention on the UI symptoms due to the high impact on their QoL.PMID:34861594 | DOI:10.1016/j.ejogrb.2021.11.424 (Source: Reproductive Biology)
Source: Reproductive Biology - December 3, 2021 Category: Reproduction Medicine Authors: Giulia Keppe Pisani Tatiana de Oliveira Sato Danilo Henrique Trevisan de Carvalho Cristiano Carvalho Source Type: research

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
CONCLUSION: Circulating ncRNAs can be valuable biomarkers used as candidates for noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. The clinical value of ncRNAs needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.PMID:34852820 | DOI:10.1186/s12958-021-00852-8 (Source: Reproductive Biology)
Source: Reproductive Biology - December 2, 2021 Category: Reproduction Medicine Authors: Sha Su Fang Yang Linlin Zhong Lihong Pang Source Type: research

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
CONCLUSION: Circulating ncRNAs can be valuable biomarkers used as candidates for noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. The clinical value of ncRNAs needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.PMID:34852820 | DOI:10.1186/s12958-021-00852-8 (Source: Reproductive Biology)
Source: Reproductive Biology - December 2, 2021 Category: Reproduction Medicine Authors: Sha Su Fang Yang Linlin Zhong Lihong Pang Source Type: research

CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis
CONCLUSIONS: CircCRIM1 bond with miR-145-5p to work as competing endogenous RNA (ceRNA) of CRIM1, and circCRIM1 bond with miR-383-5p to improve the expression of ZEB2 in ovarian cancer. CircCRIM1 and CRIM1 promoted the ovarian cancer progression and supplied a novel insight into the researches of ovarian cancer.PMID:34847936 | DOI:10.1186/s12958-021-00857-3 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Yuping Du Xin Liu Song Zhang Shuo Chen Xue Guan Qianhui Li Xi Chen Yang Zhao Source Type: research

Differences in ICSI utilization rates among states with insurance mandates for ART coverage
Reprod Biol Endocrinol. 2021 Nov 30;19(1):174. doi: 10.1186/s12958-021-00856-4.ABSTRACTBACKGROUND: Assisted reproductive technology (ART) insurance mandates promote more selective utilization of ART clinic resources including intracytoplasmic sperm injection (ICSI). Our objective was to examine whether ICSI utilization differs by state insurance mandates for ART coverage and assess if such a difference is associated with male factor, preimplantation genetic testing (PGT), and/or live birth rates.METHODS: In this retrospective analysis of the Centers for Disease Control (CDC) data from 2018, ART clinics in ART-mandated stat...
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Pavel Zagadailov Kyung S Cho David B Seifer Source Type: research

Involvement of impaired CD8 < sup > + < /sup > mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome
CONCLUSION: The impairment of CD8+MAIT cells and MDSCs is involved in the metabolic dysfunction of PCOS.PMID:34847942 | DOI:10.1186/s12958-021-00861-7 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Mengting Zhu Yuping Xu Caihua Li Zhimin Lu Kaihuan Bi Kangxia Wang Peipei Guo Huanhuan Jiang Yunxia Cao Source Type: research

Dynamics of epigenetic modifiers and environmentally sensitive proteins in a reptile with temperature induced sex reversal
Biol Reprod. 2021 Nov 26:ioab217. doi: 10.1093/biolre/ioab217. Online ahead of print.ABSTRACTThe mechanisms by which sex is determined, and how a sexual phenotype is stably maintained during adulthood, has been the focus of vigorous scientific inquiry. Resources common to the biomedical field (automated staining and imaging platforms) were leveraged to provide the first immunofluorescent data for a reptile species with temperature induced sex reversal. Two four-plex immunofluorescent panels were explored across three sex classes (sex reversed ZZf females, normal ZWf females, and normal ZZm males). One panel was stained for...
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Sarah Whiteley Robert D McCuaig Clare E Holleley Sudha Rao Arthur Georges Source Type: research

A leader and advocate for the reproductive biology community
Biol Reprod. 2021 Nov 26:ioab218. doi: 10.1093/biolre/ioab218. Online ahead of print.NO ABSTRACTPMID:34849590 | DOI:10.1093/biolre/ioab218 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Stuart B Moss Source Type: research

Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene
Biol Reprod. 2021 Nov 30:ioab220. doi: 10.1093/biolre/ioab220. Online ahead of print.NO ABSTRACTPMID:34850816 | DOI:10.1093/biolre/ioab220 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Jessica Y Chotiner N Adrian Leu Yang Xu P Jeremy Wang Source Type: research

Lipid signatures reflect the function of the murine primary placentation
Biol Reprod. 2021 Nov 30:ioab219. doi: 10.1093/biolre/ioab219. Online ahead of print.ABSTRACTThe placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid...
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Jong Geol Lee Globinna Kim Seul Gi Park Jung-Min Yon Jeonghun Yeom Ha Eun Song Seung-A Cheong Joon Seo Lim Young Hoon Sung Kyunggon Kim Hyun Ju Yoo Eui-Ju Hong Ki-Hoan Nam Je Kyung Seong Chong Jai Kim Sang-Yoon Nam In-Jeoung Baek Source Type: research

CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis
CONCLUSIONS: CircCRIM1 bond with miR-145-5p to work as competing endogenous RNA (ceRNA) of CRIM1, and circCRIM1 bond with miR-383-5p to improve the expression of ZEB2 in ovarian cancer. CircCRIM1 and CRIM1 promoted the ovarian cancer progression and supplied a novel insight into the researches of ovarian cancer.PMID:34847936 | DOI:10.1186/s12958-021-00857-3 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Yuping Du Xin Liu Song Zhang Shuo Chen Xue Guan Qianhui Li Xi Chen Yang Zhao Source Type: research

Differences in ICSI utilization rates among states with insurance mandates for ART coverage
Reprod Biol Endocrinol. 2021 Nov 30;19(1):174. doi: 10.1186/s12958-021-00856-4.ABSTRACTBACKGROUND: Assisted reproductive technology (ART) insurance mandates promote more selective utilization of ART clinic resources including intracytoplasmic sperm injection (ICSI). Our objective was to examine whether ICSI utilization differs by state insurance mandates for ART coverage and assess if such a difference is associated with male factor, preimplantation genetic testing (PGT), and/or live birth rates.METHODS: In this retrospective analysis of the Centers for Disease Control (CDC) data from 2018, ART clinics in ART-mandated stat...
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Pavel Zagadailov Kyung S Cho David B Seifer Source Type: research

Involvement of impaired CD8 < sup > + < /sup > mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome
CONCLUSION: The impairment of CD8+MAIT cells and MDSCs is involved in the metabolic dysfunction of PCOS.PMID:34847942 | DOI:10.1186/s12958-021-00861-7 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Mengting Zhu Yuping Xu Caihua Li Zhimin Lu Kaihuan Bi Kangxia Wang Peipei Guo Huanhuan Jiang Yunxia Cao Source Type: research

Dynamics of epigenetic modifiers and environmentally sensitive proteins in a reptile with temperature induced sex reversal
Biol Reprod. 2021 Nov 26:ioab217. doi: 10.1093/biolre/ioab217. Online ahead of print.ABSTRACTThe mechanisms by which sex is determined, and how a sexual phenotype is stably maintained during adulthood, has been the focus of vigorous scientific inquiry. Resources common to the biomedical field (automated staining and imaging platforms) were leveraged to provide the first immunofluorescent data for a reptile species with temperature induced sex reversal. Two four-plex immunofluorescent panels were explored across three sex classes (sex reversed ZZf females, normal ZWf females, and normal ZZm males). One panel was stained for...
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Sarah Whiteley Robert D McCuaig Clare E Holleley Sudha Rao Arthur Georges Source Type: research

A leader and advocate for the reproductive biology community
Biol Reprod. 2021 Nov 26:ioab218. doi: 10.1093/biolre/ioab218. Online ahead of print.NO ABSTRACTPMID:34849590 | DOI:10.1093/biolre/ioab218 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Stuart B Moss Source Type: research

Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene
Biol Reprod. 2021 Nov 30:ioab220. doi: 10.1093/biolre/ioab220. Online ahead of print.NO ABSTRACTPMID:34850816 | DOI:10.1093/biolre/ioab220 (Source: Reproductive Biology)
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Jessica Y Chotiner N Adrian Leu Yang Xu P Jeremy Wang Source Type: research

Lipid signatures reflect the function of the murine primary placentation
Biol Reprod. 2021 Nov 30:ioab219. doi: 10.1093/biolre/ioab219. Online ahead of print.ABSTRACTThe placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid...
Source: Reproductive Biology - December 1, 2021 Category: Reproduction Medicine Authors: Jong Geol Lee Globinna Kim Seul Gi Park Jung-Min Yon Jeonghun Yeom Ha Eun Song Seung-A Cheong Joon Seo Lim Young Hoon Sung Kyunggon Kim Hyun Ju Yoo Eui-Ju Hong Ki-Hoan Nam Je Kyung Seong Chong Jai Kim Sang-Yoon Nam In-Jeoung Baek Source Type: research

SKP2 regulates ZEB1 expression and stimulates eutopic endometrial stromal cell invasion and proliferation of adenomyosis
Reprod Biol. 2021 Nov 26;22(1):100578. doi: 10.1016/j.repbio.2021.100578. Online ahead of print.ABSTRACTThough endometriosis is benign, however, it shares certain characteristics with cancers, such as the ability to invade and metastasize. Previous studies have demonstrated that S-phase kinase associated protein2 (SKP2) promotes invasion, tumorigenesis, and metastasis. However, its correlation with adenomyosis is unclear. Herein, we aimed to look into SKP2 expression patterns and regulatory effects on endometrial stromal cell (ESC) proliferation and invasion, and its internal mechanism in adenomyosis. Western blot, qRT-PCR...
Source: Reproductive Biology - November 29, 2021 Category: Reproduction Medicine Authors: Ying Guo Jianchao Wang Chunyan Jia Ying Liao Source Type: research

Kisspeptin as autocrine/paracrine regulator of human ovarian cell functions: Possible interrelationships with FSH and its receptor
Reprod Biol. 2021 Nov 26;22(1):100580. doi: 10.1016/j.repbio.2021.100580. Online ahead of print.ABSTRACTThe present study aims to examine the role of kisspeptin (KP), FSH, and its receptor (FSHR), and their interrelationships in the control of basic human ovarian granulosa cells functions. We investigated: (1) the ability of granulosa cells to produce KP and FSHR, (2) the role of KP in the control of ovarian functions, and (3) the ability of KP to affect FSHR and to modify the FSH action on ovarian functions. The effects of KP alone (0, 10 and 100 ng/mL); or of KP (10 and 100 ng/mL) in combination with FSH (10 ng/mL) on cu...
Source: Reproductive Biology - November 29, 2021 Category: Reproduction Medicine Authors: Zuzana Fabov á Barbora Loncov á Milo š Mlynček Alexander V Sirotkin Source Type: research

SKP2 regulates ZEB1 expression and stimulates eutopic endometrial stromal cell invasion and proliferation of adenomyosis
Reprod Biol. 2021 Nov 26;22(1):100578. doi: 10.1016/j.repbio.2021.100578. Online ahead of print.ABSTRACTThough endometriosis is benign, however, it shares certain characteristics with cancers, such as the ability to invade and metastasize. Previous studies have demonstrated that S-phase kinase associated protein2 (SKP2) promotes invasion, tumorigenesis, and metastasis. However, its correlation with adenomyosis is unclear. Herein, we aimed to look into SKP2 expression patterns and regulatory effects on endometrial stromal cell (ESC) proliferation and invasion, and its internal mechanism in adenomyosis. Western blot, qRT-PCR...
Source: Reproductive Biology - November 29, 2021 Category: Reproduction Medicine Authors: Ying Guo Jianchao Wang Chunyan Jia Ying Liao Source Type: research

Kisspeptin as autocrine/paracrine regulator of human ovarian cell functions: Possible interrelationships with FSH and its receptor
Reprod Biol. 2021 Nov 26;22(1):100580. doi: 10.1016/j.repbio.2021.100580. Online ahead of print.ABSTRACTThe present study aims to examine the role of kisspeptin (KP), FSH, and its receptor (FSHR), and their interrelationships in the control of basic human ovarian granulosa cells functions. We investigated: (1) the ability of granulosa cells to produce KP and FSHR, (2) the role of KP in the control of ovarian functions, and (3) the ability of KP to affect FSHR and to modify the FSH action on ovarian functions. The effects of KP alone (0, 10 and 100 ng/mL); or of KP (10 and 100 ng/mL) in combination with FSH (10 ng/mL) on cu...
Source: Reproductive Biology - November 29, 2021 Category: Reproduction Medicine Authors: Zuzana Fabov á Barbora Loncov á Milo š Mlynček Alexander V Sirotkin Source Type: research

Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells
CONCLUSIONS: Our findings provide new insight into the molecular mechanisms by which BMP2 modulates the cellular activity induced by GDF8 through the upregulated expression of their antagonist (GREM2).PMID:34838049 | DOI:10.1186/s12958-021-00854-6 (Source: Reproductive Biology)
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Xiaoyan Luo Hsun-Ming Chang Yuyin Yi Yingpu Sun Peter C K Leung Source Type: research

An unusual case of complete atrioventricular block in twin pregnancy
Eur J Obstet Gynecol Reprod Biol. 2021 Nov 16:S0301-2115(21)00536-4. doi: 10.1016/j.ejogrb.2021.11.002. Online ahead of print.NO ABSTRACTPMID:34838328 | DOI:10.1016/j.ejogrb.2021.11.002 (Source: Reproductive Biology)
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Xavier Rafaella Jardim Keven Lima Renilton Aires Source Type: research

Physical activity and urinary incontinence during pregnancy and postpartum: A systematic review and meta-analysis
Eur J Obstet Gynecol Reprod Biol. 2021 Nov 16;267:262-268. doi: 10.1016/j.ejogrb.2021.11.005. Online ahead of print.ABSTRACTTo assess the association of physical activity and urinary incontinence, or its recovery, during pregnancy and postpartum. A search of publications indexed in five major electronic databases (CENTRAL, PubMed, EMBASE, CINAHL and PEDro) was performed from their respective inception dates to the 30 March 2020 with a combination of keywords to identify studies of interest. Google Scholar was used for non-indexed literature. All studies comparing physical activity with standard care in pregnant and postpar...
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Nadine Von Aarburg Nikolaus Veit-Rubin Michel Boulvain Jeanne Bertuit Colin Simonson David Desseauve Source Type: research

The effect of preemptive local anesthesia on postoperative pain following vaginal hysterectomy: A randomized controlled trial
CONCLUSION: Preemptive local anesthesia was not shown to be efficient in reducing postoperative pain after vaginal hysterectomy and TOT.PMID:34839248 | DOI:10.1016/j.ejogrb.2021.11.421 (Source: Reproductive Biology)
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Ohad Gluck Ohad Feldstein Elad Barber Liliya Tamayev Alexander Condrea Ehud Grinstein Ron Sagiv Inna Wolfson Jacob Bar Shimon Ginath Source Type: research

Effects of group B streptococcus infection on vaginal micro-ecology and pregnancy outcomes of pregnant women in late pregnancy
CONCLUSIONS: GBS infection is correlated with the vaginal micro-environment. GBS colonization in late pregnancy has adverse effects on vaginal micro-ecology and pregnancy outcome.PMID:34839249 | DOI:10.1016/j.ejogrb.2021.11.419 (Source: Reproductive Biology)
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Jing Huang Lili Zheng Yuan Su Fang Wang Hongfang Kong Yaqing Chang Hong Xin Source Type: research

Vaginal cysts: An important differential diagnosis in the anterior compartment
CONCLUSIONS: Anterior-compartment vaginal cysts can be found incidentally during pelvic organ prolapse assessment and surgery, as they can mimic anterior-vaginal-wall prolapse. In this cohort, all excised lesions were benign.PMID:34839250 | DOI:10.1016/j.ejogrb.2021.11.422 (Source: Reproductive Biology)
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Anke Esber Marc P Radosa Jana Wickel Henning K Mothes Ingo B Runnebaum Anke R Mothes Source Type: research

Primary toxoplasmosis acquired during early pregnancy: Is it currently overestimated?
Eur J Obstet Gynecol Reprod Biol. 2021 Nov 16;267:285-289. doi: 10.1016/j.ejogrb.2021.11.019. Online ahead of print.ABSTRACTOBJECTIVE: Toxoplasmosis acquired in early pregnancy is a potentially severe complication for the fetus. Evaluating the risk of transplacental infection in pregnant women accessing the Tuscany Reference Center for Infectious Diseases in Pregnancy during the last 20 years with suspected or confirmed toxoplasmosis acquired in early pregnancy was the aim of the study.STUDY DESIGN: We retrospectively enrolled all pregnant women undergoing amniocentesis for toxoplasmosis acquired in the first 16 gestationa...
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Michele Trotta Alessandra Trotta Elisa Spataro Susanna Giache Beatrice Borchi Lorenzo Zammarchi Irene Campolmi Luisa Galli Lucia Pasquini Source Type: research

The altered immunological status of children conceived by assisted reproductive technology
This study aimed to evaluate the impact of different embryo transfer methods and fertilization strategies on the immune status of the offspring.METHODS: A total of 69 children born to women treated with ART and a matched control group of 17 naturally conceived (NC) children, all aged from 3 to 6 years, were recruited in the reproductive hospital affiliated to Shandong University. The frequency of immune cells in the peripheral blood was assayed using flow cytometry; plasma cytokine levels were determined by multiplex cytokine immunoassay with human cytokine magnetic beads.RESULTS: Compared to children born after natural co...
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Xin Xu Han Wu Yuehong Bian Linlin Cui Yuanyuan Man Zhao Wang Xin Zhang Changming Zhang Ling Geng Source Type: research

Characteristics of the cytoplasmic halo during fertilisation correlate with the live birth rate after fresh cleaved embryo transfer on day 2 in minimal ovarian stimulation cycles: a retrospective observational study
CONCLUSIONS: Absence or prolongation of the cytoplasmic halo was negatively correlated with the live birth rate after fresh cleaved embryo transfer. The characteristics of the cytoplasmic halo were strongly associated with oocyte diameter, male age, and the initial position of the male pronucleus. These findings indicate that the characteristics of the cytoplasmic halo can be used to select more competent embryos for transfer at the cleavage stage.PMID:34836538 | DOI:10.1186/s12958-021-00859-1 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Kenji Ezoe Tetsuya Miki Tadashi Okimura Kazuo Uchiyama Akiko Yabuuchi Tamotsu Kobayashi Keiichi Kato Source Type: research

Quality of life and long-term clinical outcome following robot-assisted radical trachelectomy
CONCLUSIONS: Although robot-assisted radical trachelectomy in this cohort was associated with a low recurrence rate, a high fertility rate and an exceptionally high term delivery rate, women's quality of life was affected postoperatively, particularly with regards to their sexual well-being and lymphatic side-effects.PMID:34837852 | DOI:10.1016/j.ejogrb.2021.11.018 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Linnea Ekdahl Malin Crusensv ärd Petur Reynisson Celine L önnerfors Jan Persson Source Type: research

The effects of hysteroscopic morcellation of endometrial polyps on frozen embryo transfer outcomes
CONCLUSION(S): The data analyzed here suggest that hysteroscopic morcellation of endometrial polyps has no adverse effect on IR, SAB rate, CPR, or LBR among first FET cases after this type of polypectomy.PMID:34837853 | DOI:10.1016/j.ejogrb.2021.11.420 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Shahryar K Kavoussi Amy S Esqueda Brady T West Shu-Hung Chen Krista London Dan I Lebovic Maya Barsky Mehraban M Kavoussi Melissa S Gilkey Justin Chen John David Wininger Ellen Jatinen G Luke Machen Parviz K Kavoussi Source Type: research

Ovarian metastasis risk factors in endometrial carcinoma: A systematic review and meta-analysis
CONCLUSION: About 4.95% of EC patients develop ovarian metastasis. Age>45, myometrial invasion>1/2, cervical invasion, PLNI, pathological type, G3 pathological grade, and LVSI were the high-risk factors for ovarian metastasis of EC. Ovarian preservation should be carefully selected for patients with EC, and preoperative and intraoperative evaluations should be entirely performed.PMID:34837854 | DOI:10.1016/j.ejogrb.2021.11.016 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Xuzhi Liang Hao Zeng Sibang Chen Mingyang Jiang Siyi Liu Jiangtao Fan Source Type: research

Intraoperative tumor spill during minimally invasive hysterectomy for endometrial cancer: A survey study on experience and practice
CONCLUSION: Our survey study suggests that many surgeons experienced intraoperative tumor spillage during minimally invasive hysterectomy for endometrial cancer. These findings warrant further studies examining its incidence and impact on clinical outcomes.PMID:34837855 | DOI:10.1016/j.ejogrb.2021.11.020 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Erica J Chang Neda D Jooya Katharine M Ciesielski Mian M Shahzad Lynda D Roman Koji Matsuo Source Type: research

The altered immunological status of children conceived by assisted reproductive technology
This study aimed to evaluate the impact of different embryo transfer methods and fertilization strategies on the immune status of the offspring.METHODS: A total of 69 children born to women treated with ART and a matched control group of 17 naturally conceived (NC) children, all aged from 3 to 6 years, were recruited in the reproductive hospital affiliated to Shandong University. The frequency of immune cells in the peripheral blood was assayed using flow cytometry; plasma cytokine levels were determined by multiplex cytokine immunoassay with human cytokine magnetic beads.RESULTS: Compared to children born after natural co...
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Xin Xu Han Wu Yuehong Bian Linlin Cui Yuanyuan Man Zhao Wang Xin Zhang Changming Zhang Ling Geng Source Type: research

Characteristics of the cytoplasmic halo during fertilisation correlate with the live birth rate after fresh cleaved embryo transfer on day 2 in minimal ovarian stimulation cycles: a retrospective observational study
CONCLUSIONS: Absence or prolongation of the cytoplasmic halo was negatively correlated with the live birth rate after fresh cleaved embryo transfer. The characteristics of the cytoplasmic halo were strongly associated with oocyte diameter, male age, and the initial position of the male pronucleus. These findings indicate that the characteristics of the cytoplasmic halo can be used to select more competent embryos for transfer at the cleavage stage.PMID:34836538 | DOI:10.1186/s12958-021-00859-1 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Kenji Ezoe Tetsuya Miki Tadashi Okimura Kazuo Uchiyama Akiko Yabuuchi Tamotsu Kobayashi Keiichi Kato Source Type: research

Quality of life and long-term clinical outcome following robot-assisted radical trachelectomy
CONCLUSIONS: Although robot-assisted radical trachelectomy in this cohort was associated with a low recurrence rate, a high fertility rate and an exceptionally high term delivery rate, women's quality of life was affected postoperatively, particularly with regards to their sexual well-being and lymphatic side-effects.PMID:34837852 | DOI:10.1016/j.ejogrb.2021.11.018 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Linnea Ekdahl Malin Crusensv ärd Petur Reynisson Celine L önnerfors Jan Persson Source Type: research

The effects of hysteroscopic morcellation of endometrial polyps on frozen embryo transfer outcomes
CONCLUSION(S): The data analyzed here suggest that hysteroscopic morcellation of endometrial polyps has no adverse effect on IR, SAB rate, CPR, or LBR among first FET cases after this type of polypectomy.PMID:34837853 | DOI:10.1016/j.ejogrb.2021.11.420 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Shahryar K Kavoussi Amy S Esqueda Brady T West Shu-Hung Chen Krista London Dan I Lebovic Maya Barsky Mehraban M Kavoussi Melissa S Gilkey Justin Chen John David Wininger Ellen Jatinen G Luke Machen Parviz K Kavoussi Source Type: research

Ovarian metastasis risk factors in endometrial carcinoma: A systematic review and meta-analysis
CONCLUSION: About 4.95% of EC patients develop ovarian metastasis. Age>45, myometrial invasion>1/2, cervical invasion, PLNI, pathological type, G3 pathological grade, and LVSI were the high-risk factors for ovarian metastasis of EC. Ovarian preservation should be carefully selected for patients with EC, and preoperative and intraoperative evaluations should be entirely performed.PMID:34837854 | DOI:10.1016/j.ejogrb.2021.11.016 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Xuzhi Liang Hao Zeng Sibang Chen Mingyang Jiang Siyi Liu Jiangtao Fan Source Type: research

Intraoperative tumor spill during minimally invasive hysterectomy for endometrial cancer: A survey study on experience and practice
CONCLUSION: Our survey study suggests that many surgeons experienced intraoperative tumor spillage during minimally invasive hysterectomy for endometrial cancer. These findings warrant further studies examining its incidence and impact on clinical outcomes.PMID:34837855 | DOI:10.1016/j.ejogrb.2021.11.020 (Source: Reproductive Biology)
Source: Reproductive Biology - November 27, 2021 Category: Reproduction Medicine Authors: Erica J Chang Neda D Jooya Katharine M Ciesielski Mian M Shahzad Lynda D Roman Koji Matsuo Source Type: research

Attitudes and experiences with termination of pregnancy among Irish obstetrics & amp; gynaecology trainees in the context of recent legal change: A survey study
CONCLUSION: Irish obstetrics & gynaecology NCHDs are generally supportive of the legislation. Few trainees have performed surgical abortions, and most would like to receive additional clinical training related to ToP.PMID:34825174 | PMC:PMC8605311 | DOI:10.1016/j.eurox.2021.100137 (Source: Reproductive Biology)
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Bianca M Stifani Brendan P McDonnell Gillian Corbett Karina Avila Wendy Chavkin Noirin Russell Nerys C Benfield Source Type: research

Maternal risk factors of urinary incontinence during pregnancy and postpartum: A prospective cohort study
CONCLUSIONS: Women with UI before or during pregnancy and who are primiparous are at increased risk for postpartum UI. To prevent and reduce the risk factors contributing to UI, pregnant women should be routinely counseled.PMID:34825175 | PMC:PMC8605044 | DOI:10.1016/j.eurox.2021.100138 (Source: Reproductive Biology)
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Anna Rajavuori Jussi P Repo Arja H äkkinen Pirkko Palonen Juhani Multanen Pauliina Aukee Source Type: research

Adverse birth outcomes among women exposed to intimate partner violence in pregnancy in Ikere-Ekiti, South-west Nigeria: A prospective cohort study
Eur J Obstet Gynecol Reprod Biol. 2021 Nov 14;267:186-191. doi: 10.1016/j.ejogrb.2021.11.017. Online ahead of print.ABSTRACTOBJECTIVE: Studies on birth outcomes associated with intimate partner violence in pregnancy in Nigeria are scarce. We aimed to evaluate adverse birth outcomes among women exposed to intimate partner violence in pregnancy in a Nigerian population.STUDY DESIGN: We performed a prospective cohort study involving 363 women with singleton pregnancies presenting for antenatal care between March 2019 and September 2019. Intimate partner violence was assessed with a validated self-administered questionnaire- o...
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Temitope Omoladun Okunola Jacob Olumuyiwa Awoleke Babatunde Ajayi Olofinbiyi Babatunde Olaniyi Rosiji Sunday Omoya Abidemi Olaolu Olubiyi Source Type: research

Variable deceleration features and intrapartum fetal acidemia - The role of deceleration area
CONCLUSIONS: Deceleration area and duration were better predictors of intrapartum fetal acidemia than deceleration depth. Cumulative deceleration area>250 beats during 30 min was associated with three-fold higher odds of intrapartum acidemia compared to
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Erika Gyllencreutz Ingela Hulth én Varli Pelle G Lindqvist Malin Holzmann Source Type: research

Systematic review of sexual function in older women
CONCLUSION: Female sexual activity declines significantly with age and there is a non-significant association with poorer sexual function and decreasing sexual desire. Multiple biopsychosocial factors can impact on sexual function however, information relating to specific areas of sexual dysfunction with aging is sparse. This systematic review will inform a large-scale primary research project examining sexual function and dysfunction and impact on quality of life in older women, specifically in the context of women with pelvic floor disorders, in order to gain further insight and enhance clinical and holistic approaches t...
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Ruth A Athey Victoria Kershaw Stephen Radley Source Type: research

Efficacy of dienogest vs combined oral contraceptive on pain associated with endometriosis: Randomized clinical trial
Eur J Obstet Gynecol Reprod Biol. 2021 Oct 30;267:205-212. doi: 10.1016/j.ejogrb.2021.10.029. Online ahead of print.ABSTRACTOBJECTIVE: To compare the efficacy of dienogest with the combined oral contraceptive pill (COC) Yasmin for the control of endometriosis-associated pelvic pain.STUDY DESIGN: Seventy women with endometriosis-associated chronic pelvic pain, dysmenorrhoea or both for>6 months were randomized to either dienogest (Visanne) 2 mg/day or monophasic COC (Yasmin, 0.03 mg ethinyl estradiol and 3 mg drospirenone) for 24 weeks. The primary efficacy variable was change in non-cyclic pelvic pain and dysmenorrhoea ...
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Lina El Taha Antoine Abu Musa Dalia Khalifeh Ali Khalil Sehrish Abbasi Joseph Nassif Source Type: research

Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of preeclampsia and fetal growth restriction: A systematic review of randomized controlled trials
CONCLUSION: The two included studies showed evidence of potential benefit of antenatal low-dose aspirin on mortality and neurodevelopment up to the age of 18 months. Our findings support the current application of low-dose aspirin in pregnant women at risk for preeclampsia and fetal growth restriction. However, further follow-up research of children who were exposed to low-dose aspirin during pregnancy is of utmost importance to exclude potential long-term harm.PMID:34826669 | DOI:10.1016/j.ejogrb.2021.11.010 (Source: Reproductive Biology)
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Anadeijda J E M C Landman Emilie V J van Limburg Stirum Marjon A de Boer Janneke van 't Hooft Johannes C F Ket Aleid G Leemhuis Martijn J J Finken Martijn A Oudijk Rebecca C Painter Source Type: research

Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer
CONCLUSION: There was no significant difference of long-term post-recurrence survival outcomes between patients of epithelial OvCa with and without FSS in young women of reproductive age.PMID:34826670 | DOI:10.1016/j.ejogrb.2021.11.015 (Source: Reproductive Biology)
Source: Reproductive Biology - November 26, 2021 Category: Reproduction Medicine Authors: Munehisa Shigeyama Masato Yoshihara Kazuhisa Kitami Kazumasa Mogi Kaname Uno Shohei Iyoshi Sho Tano Nobuhisa Yoshikawa Hiroaki Kajiyama Source Type: research