Metabolic pathways of glucose and fructose: II spatiotemporal expression of genes involved in synthesis and transport of lactate in ovine conceptuses
This study characterized total lactate produced by ovine conceptuses throughout gestation, as well as expression of mRNAs and proteins involved in lactate metabolism. Lactate increased in abundance in the uterine lumen during the preimplantation period and was more abundant than pyruvate. The abundance of lactate in allantoic and amniotic fluids increased with advancing days of gestation and most abundant on Day 125 of pregnancy (P < 0.05). Lactate dehydrogenase (LDH) subunits A (converts pyruvate to lactate) and B (converts lactate to pyruvate) were expressed by conceptuses throughout gestation. Lactate is transported ...
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Robyn M Moses Claire Stenhouse Katherine M Halloran Nirvay Sah Makenzie G Newton Emily C Hoskins Shannon E Washburn Gregory A Johnson Guoyao Wu Fuller W Bazer Source Type: research
Clinical and gonadal transcriptome analysis of 38,XX disorder of sex development pigs
This study aims to investigate the phenotypic characteristics and molecular mechanisms underlying the reproductive and developmental abnormalities of 38,XX ovotestis-DSD (OT-DSD) and 38,XX testis-DSD (T-DSD) in pigs. Clinical and transcriptome sequencing analyses were performed on DSD and normal female pigs. Cytogenetic and SRY analyses confirmed that OT/T-DSD pigs exhibited a 38,XX karyotype and lacked the SRY gene. The DSD pigs had higher levels of follicle-stimulating hormone, luteinizing hormone, and progesterone, but lower testosterone levels when compared with normal male pigs. The reproductive organs of OT/T-DSD pig...
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Jinhua Wu Shuwen Tan Yi Zhou Haiquan Zhao Hui Yu Bingzhou Zhong Congying Yu Haoming Wang Yin Yang Hua Li Yugu Li Source Type: research
In Remembrance of a prolific reproductive biologist, editor of Biology of Reproduction, and enthusiastic supporter of young investigators †
Biol Reprod. 2024 Mar 25:ioae022. doi: 10.1093/biolre/ioae022. Online ahead of print.NO ABSTRACTPMID:38526867 | DOI:10.1093/biolre/ioae022 (Source: Reproductive Biology)
Source: Reproductive Biology - March 25, 2024 Category: Reproduction Medicine Authors: J Charles Eldridge Rajagopala Sridaran Darrell Brann Source Type: research
Comparison of the efficacy for early warning systems in predicting obstetric critical illness
CONCLUSION: MOEWS is more accurate than ICNARC OEWS, MEOWS chart, and MEWT in predicting the deterioration of women. The prediction ability of DBP, SBP, RR and SPO2 are more reliable.PMID:38520955 | DOI:10.1016/j.ejogrb.2024.03.025 (Source: Reproductive Biology)
Source: Reproductive Biology - March 23, 2024 Category: Reproduction Medicine Authors: Yonghui Xu Sha Zhu Hao Song Xiaoyuan Lian Maoni Zeng Ji He Lijuan Shu XinSheng Xue Fei Xiao Source Type: research
Comparison of the efficacy for early warning systems in predicting obstetric critical illness
CONCLUSION: MOEWS is more accurate than ICNARC OEWS, MEOWS chart, and MEWT in predicting the deterioration of women. The prediction ability of DBP, SBP, RR and SPO2 are more reliable.PMID:38520955 | DOI:10.1016/j.ejogrb.2024.03.025 (Source: Reproductive Biology)
Source: Reproductive Biology - March 23, 2024 Category: Reproduction Medicine Authors: Yonghui Xu Sha Zhu Hao Song Xiaoyuan Lian Maoni Zeng Ji He Lijuan Shu XinSheng Xue Fei Xiao Source Type: research
Comparison of the efficacy for early warning systems in predicting obstetric critical illness
CONCLUSION: MOEWS is more accurate than ICNARC OEWS, MEOWS chart, and MEWT in predicting the deterioration of women. The prediction ability of DBP, SBP, RR and SPO2 are more reliable.PMID:38520955 | DOI:10.1016/j.ejogrb.2024.03.025 (Source: Reproductive Biology)
Source: Reproductive Biology - March 23, 2024 Category: Reproduction Medicine Authors: Yonghui Xu Sha Zhu Hao Song Xiaoyuan Lian Maoni Zeng Ji He Lijuan Shu XinSheng Xue Fei Xiao Source Type: research
Insight into the complexity of male infertility: a multi-omics review
Syst Biol Reprod Med. 2024 Dec;70(1):73-90. doi: 10.1080/19396368.2024.2317804. Epub 2024 Mar 22.ABSTRACTMale infertility is a reproductive disorder, accounting for 40-50% of infertility. Currently, in about 70% of infertile men, the cause remains unknown. With the introduction of novel omics and advancement in high-throughput technology, potential biomarkers are emerging. The main purpose of our work was to overview different aspects of omics approaches in association with idiopathic male infertility and highlight potential genes, transcripts, non-coding RNA, proteins, and metabolites worth further exploring. Using the Ge...
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Rebeka Podgrajsek Alenka Hodzic Martin Stimpfel Tanja Kunej Borut Peterlin Source Type: research
A comparison of the clinical and histological appearances after treatment of advanced stage ovarian cancer with PlasmaJet ® device
CONCLUSION: PlasmaJet® ablated the malignant tissue in majority of the cases without causing any significant damage to the underlying tissue, it also reduced the need for stoma formation. This is a small study with encouraging results. PlasmaJet® could be a valuable tool in ovarian cancer surgery, it potentially could reduce the need for bowel surgery and allow treatment of significant mesenteric disease with reduced morbidity for the patient.PMID:38518485 | DOI:10.1016/j.ejogrb.2024.03.019 (Source: Reproductive Biology)
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Purushothaman Natarajan Alice Martha Schofield Angela Elena Vinturache Suart Ruthven Steve Lane Robert Duncan Macdonald Source Type: research
Evaluation of the thyroid gland vascularity during pregnancy using 2-dimensional color Superb Microvascular İmaging vascularization index technique
CONCLUSION: Maternal thyroid gland gray scale findings, parenchymal vascularization, thyroid volumes should be evaluated routinely for the healthy fetal development. 2D-cSMIVI method allows us to evaluate vascularization with quantitative numerical values objectively. We have detected that the VI values and volume of the thyroid gland increases as pregnancy progresses. In the complex situation of pregnancy process, the thyroid gland can be evaluated quantitatively with SMI method effectively.PMID:38518486 | DOI:10.1016/j.ejogrb.2024.03.017 (Source: Reproductive Biology)
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Fatih Ates Ömer Faruk Topaloglu Ozlem Secilmis G örkem Aktas Sibel Ozler Mehmet Sedat Durmaz Mustafa Koplay Source Type: research
PURE vs. mixed clear cell ovarian carcinomas: Is there any impact on survival?
CONCLUSION: This retrospective study showed that although mixed type histological origin was associated with higher OS and DFS rates compared to pure type in patients with CCOC, the difference was not statistically significant. Advanced age and the presence of endometriosis was found to have a significant independent effect on OS and DFS and was associated with a worse prognosis. Overall, this study provides useful insights into the clinical characteristics of patients with CCOC and identifies important prognostic factors affecting survival.PMID:38518487 | DOI:10.1016/j.ejogrb.2024.03.021 (Source: Reproductive Biology)
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Duygu G üzel Co şan Terek Ay şegül Besler G ürdeniz Serin Z üleyha Önal Levent Akman Erdem G öker Ulus Ali Şanli Osman Zekio ğlu Necmettin Özdemir Ayd ın Özsaran Nuri Yildirim Source Type: research
Sestrin2 and Sestrin3 protect spermatogenesis against heat-induced meiotic defects
Biol Reprod. 2024 Mar 22:ioae042. doi: 10.1093/biolre/ioae042. Online ahead of print.ABSTRACTHeat stress (HS) induces testicular oxidative stress, impairs spermatogenesis, and increases the risk of male infertility. Recent studies have highlighted the antioxidative properties of the Sestrins family in reducing cellular oxidative damage. However, the role of Sestrins (Sestrin1, 2, and 3) in the testicular response to heat stress remains unclear. Here, we found that Sestrin 2 and 3 were highly expressed in the testis relative to Sestrin1. Then, the Sestrin2-/- and Sestrin3-/- mice were generated by CRISPR/Cas9 to investigate...
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Wenhui Chen Mengchen Wang Huan Wang Yuqing Jiang Jing Zhu Xinxin Zeng Huihui Xie Qingling Yang Yingpu Sun Source Type: research
Interleukin-6 supplementation improves bovine conceptus elongation and transcriptomic indicators of developmental competence
Biol Reprod. 2024 Mar 22:ioae045. doi: 10.1093/biolre/ioae045. Online ahead of print.ABSTRACTA high incidence of pregnancy failures occurs in cattle during the second week of pregnancy as blastocysts transition into an elongated conceptus. This work explored whether interleukin-6 (IL6) supplementation during in vitro embryo production would improve subsequent conceptus development. Bovine embryos were treated with 0 or 100 ng/mL recombinant bovine IL6 beginning on day 5 post-fertilization. At day 7.5 post-fertilization, blastocysts were transferred into estrus synchronized beef cows (n = 5 recipients/treatment, 10 embryos/...
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Savannah L Speckhart Mary A Oliver Jessica A Keane Nicholas W Dias Vitor R G Mercadante Fernando H Biase Alan D Ealy Source Type: research
Ultrasound features of a bilineal inheritance of autosomal dominant polycystic kidney disease
Eur J Obstet Gynecol Reprod Biol. 2024 Mar 19:S0301-2115(24)00146-5. doi: 10.1016/j.ejogrb.2024.03.026. Online ahead of print.NO ABSTRACTPMID:38519376 | DOI:10.1016/j.ejogrb.2024.03.026 (Source: Reproductive Biology)
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Elisa Montaguti Francesca Montanari Vito Bernardi Elena Luppi Pierandrea De Benedetti Giulia Lanzoni Marco Seri Gianluigi Pilu Source Type: research
Insight into the complexity of male infertility: a multi-omics review
Syst Biol Reprod Med. 2024 Dec;70(1):73-90. doi: 10.1080/19396368.2024.2317804. Epub 2024 Mar 22.ABSTRACTMale infertility is a reproductive disorder, accounting for 40-50% of infertility. Currently, in about 70% of infertile men, the cause remains unknown. With the introduction of novel omics and advancement in high-throughput technology, potential biomarkers are emerging. The main purpose of our work was to overview different aspects of omics approaches in association with idiopathic male infertility and highlight potential genes, transcripts, non-coding RNA, proteins, and metabolites worth further exploring. Using the Ge...
Source: Reproductive Biology - March 22, 2024 Category: Reproduction Medicine Authors: Rebeka Podgrajsek Alenka Hodzic Martin Stimpfel Tanja Kunej Borut Peterlin Source Type: research
A modern-day litmus test for the sustainability of daily IVF practice - Alabama supreme court ruling overreaches in asserting that frozen embryos are legally children
Reprod Biol Endocrinol. 2024 Mar 21;22(1):33. doi: 10.1186/s12958-024-01201-1.NO ABSTRACTPMID:38509519 | PMC:PMC10956278 | DOI:10.1186/s12958-024-01201-1 (Source: Reproductive Biology)
Source: Reproductive Biology - March 21, 2024 Category: Reproduction Medicine Authors: David B Seifer Source Type: research
