Quantification of follicles in human ovarian tissue using image processing software and trained artificial intelligence
Biol Reprod. 2024 Mar 27:ioae048. doi: 10.1093/biolre/ioae048. Online ahead of print.ABSTRACTCancer survival rates in prepubertal girls and young women have risen in recent decades due to increasingly efficient treatments. However, many such treatments are gonadotoxic, causing premature ovarian insufficiency (POI), loss of fertility and ovarian endocrine function. Implantation of donor ovarian tissue encapsulated in immune-isolating capsules is a promising method to restore physiological endocrine function without immunosuppression or risk of reintroducing cancer cells harbored by the tissue. The success of this approach i...
Source: Reproductive Biology - March 27, 2024 Category: Reproduction Medicine Authors: Gabrielle M Blevins Colleen L Flanagan Sridula S Kallakuri Owen M Meyer Likitha Nimmagadda James D Hatch Sydney A Shea Vasantha Padmanabhan Ariella Shikanov Source Type: research
Survival in pregnancy-associated breast cancer patients compared to non-pregnant controls
CONCLUSIONS: The outcome of women diagnosed with PABC is comparable to young non-pregnant controls. However, it should be taken into account that PABC has a more aggressive phenotype.PMID:38532462 | PMC:PMC10964548 | DOI:10.1186/s12958-024-01206-w (Source: Reproductive Biology)
Source: Reproductive Biology - March 27, 2024 Category: Reproduction Medicine Authors: Mar ía Martín Cameán Ibon Jaunarena Marin Jose Ignacio S ánchez Mendez Covadonga Mart í Alvarez F élix Boria Alegre Elena Mart ín Boado Emanuela Spagnolo Ignacio Zapardiel Alicia Hern ández Gutiérrez Source Type: research
Plasma and peritoneal fluid cytokine profiles in patient with Essure ® implant: Towards a molecular signature?
CONCLUSIONS: The chemokine MCP-1 as well as the pro-inflammatory TNF-α, are known to be increased in patients with fibromyalgia and chronic fatigue syndrome. Since patients with Essure® may exhibit symptoms similar to fibromyalgia, MCP-1 and TNF-α may be relevant markers in symptomatic patients with Essure®. Because of the lack of longitudinal data (no evaluation of postoperative cytokine profile and no assessment of the level of clinical improvement), other studies are needed to confirm these preliminary results.PMID:38537321 | DOI:10.1016/j.ejogrb.2024.03.031 (Source: Reproductive Biology)
Source: Reproductive Biology - March 27, 2024 Category: Reproduction Medicine Authors: Lorna Garnier Fran çois Parant Claire Bulteau Remi Pescarmona Emanuele Cerruto Stephanie Moret Chloe Miguet-Bensouda Erdogan Nohuz Gautier Chene Source Type: research
IVF outcomes pre- and post-anti-COVID-19 vaccination - Are there any differences?
This study emphasized that the mRNA anti-COVID-19 vaccination doesn't adversely affect ovarian response or sperm quality in IVF patients. These findings contribute valuable insights to the safety profile of anti-COVID-19 vaccines in the context of reproductive-aged populations, aiding decision-making during ongoing virus outbreaks and potential future scenarios.PMID:38537543 | DOI:10.1016/j.repbio.2024.100879 (Source: Reproductive Biology)
Source: Reproductive Biology - March 27, 2024 Category: Reproduction Medicine Authors: Marina Arselia Fradkin Heli Alexandroni Talia Eldar-Geva Ido Ben-Ami Source Type: research
Quantification of follicles in human ovarian tissue using image processing software and trained artificial intelligence
Biol Reprod. 2024 Mar 27:ioae048. doi: 10.1093/biolre/ioae048. Online ahead of print.ABSTRACTCancer survival rates in prepubertal girls and young women have risen in recent decades due to increasingly efficient treatments. However, many such treatments are gonadotoxic, causing premature ovarian insufficiency (POI), loss of fertility and ovarian endocrine function. Implantation of donor ovarian tissue encapsulated in immune-isolating capsules is a promising method to restore physiological endocrine function without immunosuppression or risk of reintroducing cancer cells harbored by the tissue. The success of this approach i...
Source: Reproductive Biology - March 27, 2024 Category: Reproduction Medicine Authors: Gabrielle M Blevins Colleen L Flanagan Sridula S Kallakuri Owen M Meyer Likitha Nimmagadda James D Hatch Sydney A Shea Vasantha Padmanabhan Ariella Shikanov Source Type: research
Effects of paternal ionizing radiation exposure on fertility and offspring's health
CONCLUSION: The male mice could have healthy offspring after recovery from the damage caused by ionizing radiation.PMID:38528990 | PMC:PMC10961711 | DOI:10.1002/rmb2.12567 (Source: Reproductive Biology)
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Jiaqun Li Juan Liu Yanye Zhang Hong Qiu Junyan Zheng Jinglei Xue Jiani Jin Feida Ni Chunxi Zhang Chuan Chen Xiao Sun Huiquan Wang Dan Zhang Source Type: research
Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta-analysis
CONCLUSION: Follitropin δ may result in little to no difference in COS compared with follitropin α/β, especially in terms of live births and safety.PMID:38528991 | PMC:PMC10961712 | DOI:10.1002/rmb2.12573 (Source: Reproductive Biology)
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Shinnosuke Komiya Jun Watanabe Takero Terayama Kyosuke Kamijo Hidetaka Okada Source Type: research
Perioperative intravenous infusion of dexmedetomidine for alleviating postpartum depression after cesarean section: A meta-analysis and systematic review
Eur J Obstet Gynecol Reprod Biol. 2024 Mar 21;296:333-341. doi: 10.1016/j.ejogrb.2024.03.024. Online ahead of print.ABSTRACTThe efficacy of perioperative dexmedetomidine (DEX) infusion as a precaution against postpartum depression (PPD) in women undergoing cesarean section has not been substantiated systematically. A literature search for RCTs on DEX against PPD was retrieved in the following databases from inception to January 3, 2024: PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang, CBM, VIP, etc. A total of 13 RCTs with 1711 participants were included. Meta-analysis was performed by RevMan5.3 and Sta...
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Shouyu Xu Yingyong Zhou Saiying Wang Qiuwen Li Yunfei Feng Liang Chen Kaiming Duan Source Type: research
Evaluation of Elastic Venous Compression Device dispensation in pregnant and post-partum women using the French National Health Insurance Claims Database: The ProFIL retrospective cohort study
CONCLUSIONS: Low observed dispensation rates highlight a discrepancy between the French National Authority for Health (Haute Autorité de Santé, HAS), recommending EVCDs use during pregnancy and after delivery, and the real-life use of EVCD. Prescription sensitization combined with targeted information campaigns for pregnant women would be beneficial to contribute to the prevention of VTE, a health problem for pregnant women.PMID:38531180 | DOI:10.1016/j.ejogrb.2024.03.014 (Source: Reproductive Biology)
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Olivier Joassard Anne-Laure Kerveillant Claire Sellal Erwana Coatantiec Violaine Jabbour Guillaume Desjeux Ben Braithwaite Antoine Elias Arnaud Fauconnier Source Type: research
Metabolic pathways of glucose and fructose: II spatiotemporal expression of genes involved in synthesis and transport of lactate in ovine conceptuses
This study characterized total lactate produced by ovine conceptuses throughout gestation, as well as expression of mRNAs and proteins involved in lactate metabolism. Lactate increased in abundance in the uterine lumen during the preimplantation period and was more abundant than pyruvate. The abundance of lactate in allantoic and amniotic fluids increased with advancing days of gestation and most abundant on Day 125 of pregnancy (P < 0.05). Lactate dehydrogenase (LDH) subunits A (converts pyruvate to lactate) and B (converts lactate to pyruvate) were expressed by conceptuses throughout gestation. Lactate is transported ...
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Robyn M Moses Claire Stenhouse Katherine M Halloran Nirvay Sah Makenzie G Newton Emily C Hoskins Shannon E Washburn Gregory A Johnson Guoyao Wu Fuller W Bazer Source Type: research
Clinical and gonadal transcriptome analysis of 38,XX disorder of sex development pigs
This study aims to investigate the phenotypic characteristics and molecular mechanisms underlying the reproductive and developmental abnormalities of 38,XX ovotestis-DSD (OT-DSD) and 38,XX testis-DSD (T-DSD) in pigs. Clinical and transcriptome sequencing analyses were performed on DSD and normal female pigs. Cytogenetic and SRY analyses confirmed that OT/T-DSD pigs exhibited a 38,XX karyotype and lacked the SRY gene. The DSD pigs had higher levels of follicle-stimulating hormone, luteinizing hormone, and progesterone, but lower testosterone levels when compared with normal male pigs. The reproductive organs of OT/T-DSD pig...
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Jinhua Wu Shuwen Tan Yi Zhou Haiquan Zhao Hui Yu Bingzhou Zhong Congying Yu Haoming Wang Yin Yang Hua Li Yugu Li Source Type: research
Effects of paternal ionizing radiation exposure on fertility and offspring's health
CONCLUSION: The male mice could have healthy offspring after recovery from the damage caused by ionizing radiation.PMID:38528990 | PMC:PMC10961711 | DOI:10.1002/rmb2.12567 (Source: Reproductive Biology)
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Jiaqun Li Juan Liu Yanye Zhang Hong Qiu Junyan Zheng Jinglei Xue Jiani Jin Feida Ni Chunxi Zhang Chuan Chen Xiao Sun Huiquan Wang Dan Zhang Source Type: research
Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta-analysis
CONCLUSION: Follitropin δ may result in little to no difference in COS compared with follitropin α/β, especially in terms of live births and safety.PMID:38528991 | PMC:PMC10961712 | DOI:10.1002/rmb2.12573 (Source: Reproductive Biology)
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Shinnosuke Komiya Jun Watanabe Takero Terayama Kyosuke Kamijo Hidetaka Okada Source Type: research
Perioperative intravenous infusion of dexmedetomidine for alleviating postpartum depression after cesarean section: A meta-analysis and systematic review
Eur J Obstet Gynecol Reprod Biol. 2024 Mar 21;296:333-341. doi: 10.1016/j.ejogrb.2024.03.024. Online ahead of print.ABSTRACTThe efficacy of perioperative dexmedetomidine (DEX) infusion as a precaution against postpartum depression (PPD) in women undergoing cesarean section has not been substantiated systematically. A literature search for RCTs on DEX against PPD was retrieved in the following databases from inception to January 3, 2024: PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang, CBM, VIP, etc. A total of 13 RCTs with 1711 participants were included. Meta-analysis was performed by RevMan5.3 and Sta...
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Shouyu Xu Yingyong Zhou Saiying Wang Qiuwen Li Yunfei Feng Liang Chen Kaiming Duan Source Type: research
Evaluation of Elastic Venous Compression Device dispensation in pregnant and post-partum women using the French National Health Insurance Claims Database: The ProFIL retrospective cohort study
CONCLUSIONS: Low observed dispensation rates highlight a discrepancy between the French National Authority for Health (Haute Autorité de Santé, HAS), recommending EVCDs use during pregnancy and after delivery, and the real-life use of EVCD. Prescription sensitization combined with targeted information campaigns for pregnant women would be beneficial to contribute to the prevention of VTE, a health problem for pregnant women.PMID:38531180 | DOI:10.1016/j.ejogrb.2024.03.014 (Source: Reproductive Biology)
Source: Reproductive Biology - March 26, 2024 Category: Reproduction Medicine Authors: Olivier Joassard Anne-Laure Kerveillant Claire Sellal Erwana Coatantiec Violaine Jabbour Guillaume Desjeux Ben Braithwaite Antoine Elias Arnaud Fauconnier Source Type: research
