The potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses.
CONCLUSIONS: The present study revealed the involvement of GnRH in the regulation of gonadotropin biosynthesis and metabolism in the maintenance of reproduction, achieved by bioinformatics analyses. This, indicates that the GnRH signalling pathway played a central linkings role in reproductive function and metabolic balance. In addition, the present study identified the difference response between GnRH pulse and GnRH tone, indicated that abnormal GnRH pulse and amplitude may cause disease, which may provide an improved understanding of the GnRH pathway and a new insight for disease diagnosis and treatment. PMID: 28623...
Source: Reproductive Biology - June 17, 2017 Category: Reproduction Medicine Authors: Xiang W, Zhang B, Lv F, Feng G, Chen L, Yang F, Zhang K, Cao C, Wang P, Chu M Tags: Reprod Biol Endocrinol Source Type: research

Expression of hypoxia inducible factor 1 α and antioxidant enzymes: Superoxide dismutases-1 and -2 in ischemic porcine endometrium.
Expression of hypoxia inducible factor 1α and antioxidant enzymes: Superoxide dismutases-1 and -2 in ischemic porcine endometrium. Reprod Biol. 2017 Jun 14;: Authors: Kwiatkowska J, Wąsowska B, Gilun P Abstract The aim of this study was to determine how 60-min ischemia changes the expression of hypoxia inducible factor 1α (HIF-1α) and superoxide dismutases (SOD)-1 and -2 in selected regions of porcine uterine horns. The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1α and increased SOD-2 gene express...
Source: Reproductive Biology - June 14, 2017 Category: Reproduction Medicine Authors: Kwiatkowska J, Wąsowska B, Gilun P Tags: Reprod Biol Source Type: research

Immaturity for gestational age of microvasculature and placental barrier in term placentas with high weight.
CONCLUSION: We have identified the immaturity of microvasculature and PB -associated capillaries with a pathological persistency of immature CD15+/CD31+/CD34+ endothelial cells and a reduction of terminally differentiated CD15-/CD31+/CD34+ endothelial cells in a structurally and clinically heterogeneous group of high weight-placentas. We assume that immaturity of placental vessels are part of prenatal adaptational processes that can be recruited in different emergency situations and may provide potential targets of therapeutic correction of placental growth and chronic insufficiency. We therefore recommend the use of CD15-...
Source: Reproductive Biology - June 13, 2017 Category: Reproduction Medicine Authors: Seidmann L, Kamyshanskiy Y, Martin SZ, Fruth A, Roth W Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Preoperative serum levels of YKL 40 and CA125 as a prognostic indicators in patients with endometrial cancer.
CONCLUSIONS: A high diagnostic sensitivity of YKL-40 in the early stages of the disease suggests the possibility of using this biomarker at an early diagnostic phase of patients with EC. The patients with increased levels of YKL-40 before treatment are also at the higher risk of relapse. The determination of CA125 before surgery may be helpful in the evaluation of the regional lymph nodes, and is a poor prognostic factor for OS and DFS. PMID: 28624692 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - June 13, 2017 Category: Reproduction Medicine Authors: Kotowicz B, Fuksiewicz M, Jonska-Gmyrek J, Wagrodzki M, Kowalska M Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Differences in utilization of Intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S.
Abstract BACKGROUND: Anecdotal evidence suggests that US practice patterns for ART differ by geographical region. The purpose of this study was to determine whether use of ICSI differs by region and to evaluate whether these rates are correlated with differences in live birth rates. METHODS: Public data for 2012 were obtained from the Centers for Disease Control and Prevention. Clinics with ≥100 fresh, non-donor cycles were grouped by 10 nationally recognized Department of Health & Human Services regions and 11 metropolitan Megaregions and were compared for use of ICSI, frequency of male factor in...
Source: Reproductive Biology - June 12, 2017 Category: Reproduction Medicine Authors: Zagadailov P, Hsu A, Seifer DB, Stern JE Tags: Reprod Biol Endocrinol Source Type: research

Feasibility of screening and prevalence of prenatal depression in an obstetric setting in Spain.
CONCLUSION: It is possible to integrate screening for prenatal depression in an urban obstetrics setting, but there are significant structural barriers to implementation. The prevalence of significant prenatal depressive symptoms is similar to previous research in Spain and adds to the limited research in this area. PMID: 28605666 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - June 9, 2017 Category: Reproduction Medicine Authors: de la Fe Rodríguez-Muñoz M, Le HN, de la Cruz IV, Crespo MEO, Méndez NI Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Small for gestational age and perinatal mortality at term: An audit in a Dutch national cohort study.
CONCLUSIONS: Gestational age of 37 completed weeks, male gender, South Asian, African or other non-Western ethnicity and smoking are associated with perinatal mortality in SGA infants. These risk factors concern the complete term population starting at 37 weeks or even earlier. Therefore, it is of utmost importance to develop accurate diagnostic tests to screen for SGA before 36 weeks gestation to prevent perinatal mortality at term in SGA infants. PMID: 28601729 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - June 8, 2017 Category: Reproduction Medicine Authors: Eskes M, Waelput AJM, Scherjon SA, Bergman KA, Abu-Hanna A, Ravelli ACJ Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA.
CONCLUSION: Utilization of ART is inversely related to fertility rates. Autologous ART produces lower live birth rates among Asian and Black women. 3ART results in relatively low live birth rates among Black women. TRIAL REGISTRATION: SART CORS #57 , Registered 5/14/2015. PMID: 28595591 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - June 8, 2017 Category: Reproduction Medicine Authors: Shapiro AJ, Darmon SK, Barad DH, Albertini DF, Gleicher N, Kushnir VA Tags: Reprod Biol Endocrinol Source Type: research

The path of the sperm to the oocyte.
This article is protected by copyright. All rights reserved. PMID: 28577317 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - June 3, 2017 Category: Reproduction Medicine Authors: La Spina FA, Buffone MG Tags: Mol Reprod Dev Source Type: research

Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM - a microarray approach.
CONCLUSIONS: Increased expression of CHRDL1, FST, TGFβR3, SMAD4, and ID1 transcripts before IVM suggested a subordinate role of the BMP signaling pathway in porcine oocyte maturational competence. Conversely, it is postulated that these genes are involved in early stages of folliculogenesis and oogenesis regulation in pigs, since in oocytes before IVM increased expression was observed. PMID: 28576120 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - June 2, 2017 Category: Reproduction Medicine Authors: Budna J, Rybska M, Ciesiółka S, Bryja A, Borys S, Kranc W, Wojtanowicz-Markiewicz K, Jeseta M, Sumelka E, Bukowska D, Antosik P, Brüssow KP, Bruska M, Nowicki M, Zabel M, Kempisty B Tags: Reprod Biol Endocrinol Source Type: research

The Second Victim: a Review.
Abstract Amongst the lay and media population there is a perception that pregnancy, labour and delivery is always physiological, morbidity and mortality should be "never events" and that error is the only cause of adverse events. Those working in maternity care know that it is an imperfect art, where adverse outcomes and errors will occur. When errors do occur, there is a domino effect with three groups being involved - the patient (first victim), the staff (second victims) and the organization (third victims). If the perceived expectation of patients on all clinicians is that of perfection, then clinici...
Source: Reproductive Biology - May 21, 2017 Category: Reproduction Medicine Authors: Coughlan B, Powell D, Higgins MF Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Live, full-term mouse pups from oocytes grown and matured in vitro with serum substitutes.
Abstract For in vitro growth and maturation of mouse oocytes (IVG-IVM), serum is added to media up to and including the stage of oocyte maturation; this subsequently supports oocytes through fertilization and early embryo development. However, problems may occur with sera, such as batch differences and issues of biosafety. The purpose of the present study was to determine the capacity for fertilization and pre- and post-implantation development of oocytes that underwent IVG-IVM with a serum substitute. Oocyte-granulosa cell complexes from preantral follicles were cultured in medium with either fetal bovine serum (...
Source: Reproductive Biology - May 13, 2017 Category: Reproduction Medicine Authors: Motohashi HH, Taniguchi R, Sakamoto J, Sankai T, Kada H Tags: Reprod Biol Source Type: research

Comparative characteristics of spermatozoa harvested and cryopreserved in culture and cryoprotectant media with or without donor serum proteins.
In conclusion synthetic protein-free culture and cryoprotectant media are equal in efficacy to protein-containing media in culture and cryopreservation of spermatozoa . Use of these synthetic media are anticipated to significantly reduce the risk, potentially associated with conventional protein-containing media, of transmission of disease and possibly harmful undeclared proteins to the patient, baby and the healtcare worker. Synthetic media also ensure consistency of quality between batches of media. PMID: 28511996 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - May 13, 2017 Category: Reproduction Medicine Authors: Ata'Allah GA, Adenan NAM, Razali N, Palaniappan K, Saad R, Idris SK, Kanniah K, Ali J Tags: Reprod Biol Source Type: research

Role of microRNAs in premature ovarian insufficiency.
Abstract Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women
Source: Reproductive Biology - May 12, 2017 Category: Reproduction Medicine Authors: Guo Y, Sun J, Lai D Tags: Reprod Biol Endocrinol Source Type: research

Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator.
CONCLUSIONS: Pregnancy rates in IVF/ICSI cycles with integrated time-lapse incubation and transfer on day 4 and 5 are comparable. This finding provides the clinician, IVF laboratory and patient with more flexibility. TRIAL REGISTRATION: This study was retrospectively registered by the local ethics committee of the University of Heidelberg on December 19, 2016 (registration number S-649/2016). PMID: 28482910 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - May 8, 2017 Category: Reproduction Medicine Authors: Holschbach V, Weigert J, Dietrich JE, Roesner S, Montag M, Strowitzki T, Toth B Tags: Reprod Biol Endocrinol Source Type: research

Low serum concentration in bovine embryo culture enhances early blastocyst rates on Day-6 with quality traits in the expanded blastocyst stage similar to BSA-cultured embryos.
;nez-Nistal A, Gómez E Abstract In bovine, single in vitro embryo culture in protein-free medium from Day-6 to Day-7 leads to expanded blastocyst (XB) with improved pregnancy and birth rates after cryopreservation. Under these conditions, early blastocysts (EB) progress to the XB stage at higher rates than morulae (M). However, embryo production with BSA in culture prior to Day-6 leads to low EB rates. We investigated whether a very low FCS concentration (0.1%) in culture from Day-1 to Day-6 would improve EB rates and, subsequently, increase XB rates on Day-7 after single culture in protein-free medium. The...
Source: Reproductive Biology - May 4, 2017 Category: Reproduction Medicine Authors: Murillo A, Muñoz M, Martín-González D, Carrocera S, Martínez-Nistal A, Gómez E Tags: Reprod Biol Source Type: research

Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis.
CONCLUSIONS: The risks of preterm and very preterm births increased after fresh blastocyst transfers versus the risks after fresh cleavage-stage embryo transfers. However, in frozen embryo transfers, there were no differences. Blastocyst embryo transfers resulted in high risks of infants who were large for gestational age, and cleavage-stage embryo transfers resulted in high risks of infants who were small for gestational age. PMID: 28472983 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - May 4, 2017 Category: Reproduction Medicine Authors: Wang X, Du M, Guan Y, Wang B, Zhang J, Liu Z Tags: Reprod Biol Endocrinol Source Type: research

Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats.
CONCLUSIONS: These data suggest that intracerebroventricular injection of RFRP-3 significantly delays the onset of puberty in female rats. Additionally, RFRP-3 may be associated with prepubertal rise in the secretion of growth hormone. PMID: 28464910 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - May 2, 2017 Category: Reproduction Medicine Authors: Han X, He Y, Zeng G, Wang Y, Sun W, Liu J, Sun Y, Yu J Tags: Reprod Biol Endocrinol Source Type: research

Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study.
CONCLUSIONS: Together these findings suggest that FMR1 CGG repeat length may have a role in determining X-chromosome inactivation which could represent a possible mechanism for previously observed association of low age adjusted ovarian reserve with FMR1 variations in repeat length. Further, larger, investigations will be required to test this hypothesis. PMID: 28454580 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 28, 2017 Category: Reproduction Medicine Authors: Barad DH, Darmon S, Weghofer A, Latham GJ, Filipovic-Sadic, Wang Q, Kushnir VA, Albertini DF, Gleicher N Tags: Reprod Biol Endocrinol Source Type: research

A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use.
CONCLUSIONS: As currently performed, a single TEB is, therefore, mathematically incapable of reliably determining whether an embryo can be transferred or should be discarded. Since a single TEB, as currently performed, apparently is not representative of the complete TE, this study, thus, raises additional concern about the clinical utilization of PGS. PMID: 28449669 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 27, 2017 Category: Reproduction Medicine Authors: Gleicher N, Metzger J, Croft G, Kushnir VA, Albertini DF, Barad DH Tags: Reprod Biol Endocrinol Source Type: research

Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype.
CONCLUSIONS: Our study demonstrates that pre-selecting a sperm donor whose haplotype has minimal overlapping with the female's haplotype, is critical for reducing the misdiagnosis risk and ensuring a reliable PGD. This strategy may contribute to prevent the transmission of affected IVF-PGD embryos using a simple and economical procedure. TRIAL REGISTRATION: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. D...
Source: Reproductive Biology - April 26, 2017 Category: Reproduction Medicine Authors: Malcov M, Gold V, Peleg S, Frumkin T, Azem F, Amit A, Ben-Yosef D, Yaron Y, Reches A, Barda S, Kleiman SE, Yogev L, Hauser R Tags: Reprod Biol Endocrinol Source Type: research

Effect of different artificial shrinkage methods, when applied before blastocyst vitrification, on perinatal outcomes.
In this study, we aimed to compare the clinical outcomes and neonatal outcomes in FET cycles with single blastocyst that were artificially shrunk before vitrification by either LAS or MNAS method. METHODS: A retrospective comparative study of FET cycles in infertile patients which were at our clinic between January 2013 and December 2014. These FET cycles were divided into two groups by the shrinking methods used before vitrification and the clinical and neonatal outcomes were assessed. RESULTS: There were no statistically differences in blastocyst survival rates (95.40% vs 94.05%, P > 0.05) betw...
Source: Reproductive Biology - April 26, 2017 Category: Reproduction Medicine Authors: Wang C, Feng G, Zhang B, Zhou H, Shu J, Lin R, Chen H, Wu Z Tags: Reprod Biol Endocrinol Source Type: research

Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle.
CONCLUSION: Current results not only support the expression of enzymes involved in sex steroid synthesis in the wall of the vagina, they also indicate that expression changes with the stage of the cycle, both the levels and types of cells exhibiting expression. Thus, changes in proliferation of vaginal epithelial cells and the differentiation of the mucosa may be influenced by local steroid synthesis as well as circulating androgens and estrogens. PMID: 28438170 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 24, 2017 Category: Reproduction Medicine Authors: Dos Santos AC, Conley AJ, de Oliveira MF, Oliveira GB, Viana DC, Assis Neto AC Tags: Reprod Biol Endocrinol Source Type: research

Efficient vitrification of mouse embryos using the Kitasato Vitrification System as a novel vitrification device.
CONCLUSIONS: Our study clearly demonstrates that the KVS is a novel vitrification device for the cryopreservation of mouse embryos at the blastocyst and 2-cell stage. PMID: 28438181 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 24, 2017 Category: Reproduction Medicine Authors: Momozawa K, Matsuzawa A, Tokunaga Y, Abe S, Koyanagi Y, Kurita M, Nakano M, Miyake T Tags: Reprod Biol Endocrinol Source Type: research

Chapter 8 Human Oocytes Slow-Rate Freezing: Methodology.
ini A Abstract Cryopreservation of human oocytes is an important technique for the treatment of human infertility, as it deals successfully with legal, ethical, and moral issues related to embryo cryopreservation (Coticchio et al., Human Fertil (Camb) 4:152-157, 2001; Tucker et al., Eur J Obstet Gynecol Reprod Biol 113: 524-527, 2004) and maintains reproductive potential in women with diseases or conditions that may compromise reproductive capacity. Here, we describe an oocyte cryopreservation technique involving slow freezing-rapid thawing with differential sucrose concentration (0.2 M in the freezing stage-...
Source: Reproductive Biology - April 21, 2017 Category: Reproduction Medicine Authors: Zacà C, Borini A Tags: Methods Mol Biol Source Type: research

Chapter 15 Development of a Nationwide Network for Ovarian Tissue Cryopreservation.
Abstract Ovarian tissue cryopreservation is gaining much interest since the publication of the first live birth after retransplantation of frozen-thawed tissue in 2004 (Donnez et al., Lancet 364:1405-1410, 2004). In contrast to cryopreservation of gametes and embryos, ovarian tissue freezing is a complex requiring a proper approach in order to make this a viable option for fertility preservation of cancer patients. Due to the need in terms of laboratory space, equipment, personnel, and adequate logistics, an ovarian tissue cryobank is most economic if managed as a centralized service unit that interacts with numer...
Source: Reproductive Biology - April 21, 2017 Category: Reproduction Medicine Authors: Liebenthron J, Montag M Tags: Methods Mol Biol Source Type: research

Appendix D: Irvine Scientific( ®) Vitrification System.
Appendix D: Irvine Scientific(®) Vitrification System. Methods Mol Biol. 2017;1568:317-334 Authors: VerMilyea M, Brewer A Abstract This chapter will describe the use of the Irvine Scientific(®) vitrification and warming solutions (Vit Kits(®)) along with a detailed protocol for the correct use of the CryoTip(®) vitrification device for human embryos and oocytes. Successful pregnancies have been reported after carrying out rapid vitrification methods of oocytes, cleavage stage embryos, and blastocysts using the CryoTip(®) (Popwell et al. Fertil Steril, 101:e20, 2014; Kuwayama et al....
Source: Reproductive Biology - April 21, 2017 Category: Reproduction Medicine Authors: VerMilyea M, Brewer A Tags: Methods Mol Biol Source Type: research

Prenatal diagnosis of Ectrodactyly-Ectodermal dysplasia-Cleft (EEC) syndrome in a Chinese woman with a TP63 mutation.
PMID: 28420484 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - April 10, 2017 Category: Reproduction Medicine Authors: Yang Y, Huang LY, Han J, Li DZ Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

A comparison between reduced-port robotic surgery and multiport robot-assisted laparoscopy for myomectomy.
CONCLUSION: RPRS for myomectomy seems technically feasible and safe, with short-term perioperative outcomes similar to those from multiport robot-assisted laparoscopic myomectomy. PMID: 28426944 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - April 10, 2017 Category: Reproduction Medicine Authors: Nam SH, Paek J, Choi C, Nam SH, Kim WY Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Erratum to: Comment on: Gleicher N et al.,2016. Reprod biol endocrinol Sep 5;14(1):54.
rtz B PMID: 28395662 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 10, 2017 Category: Reproduction Medicine Authors: Tiegs AW, Grifo JA, Munné S, McCulloh DH, Hodes-Wertz B Tags: Reprod Biol Endocrinol Source Type: research

Reprod Biol; +106 new citations
106 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Reprod Biol These pubmed results were generated on 2017/04/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Reproductive Biology)
Source: Reproductive Biology - April 8, 2017 Category: Reproduction Medicine Tags: Report Source Type: research

Response to comment on: Gleicher N et al., 2016. Reprod biol endocrinol Sep 5;14(1):54.
rtz B PMID: 28376830 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 5, 2017 Category: Reproduction Medicine Authors: Tiegs AW, Grifo JA, Munné S, McCulloh DH, Hodes-Wertz B Tags: Reprod Biol Endocrinol Source Type: research

Response to comment on: Gleicher N et al., 2016. Reprod biol endocrinol Sep 5;14(1):54.
PMID: 28376927 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - April 5, 2017 Category: Reproduction Medicine Authors: Gleicher N, Vidali A, Braverman J, Kushnir VA, Barad DH, Hudson C, Wu YG, Wang Q, Zhang L Tags: Reprod Biol Endocrinol Source Type: research

Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus.
lazar C, Órnelas-Vázquez JK Abstract BACKGROUND: The purpose of this study was to determine the mitochondrial content, and the oxidative and nitrosative stress of the placenta in women with gestational diabetes mellitus (GDM). METHODS: Full-term placentas from GDM and healthy pregnancies were collected following informed consent. The lipid peroxidation (TBARS) and oxidized protein (carbonyls) levels were determined by spectrophotometry, and 3-nitrotyrosine (3-NT), subunit IV of cytochrome oxidase (COX4), adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and actin were determined b...
Source: Reproductive Biology - April 4, 2017 Category: Reproduction Medicine Authors: Ramírez-Emiliano J, Fajardo-Araujo ME, Zúñiga-Trujillo I, Pérez-Vázquez V, Sandoval-Salazar C, Órnelas-Vázquez JK Tags: Reprod Biol Endocrinol Source Type: research

Efficacy and safety of varicocelectomies: A meta-analysis.
This study reviewed the efficacy and safety of the three surgical approaches for varicocele (microsurgical, laparoscopic, and open varicocelectomy). A systematic review of the relevant randomized clinical trials was performed. Trials were identified from specialized trials register of the Cochrane UGDP Group, the Cochrane library, additional electronic searches (mainly MEDLINE, EMBSAE, SCI, CBM), and handsearching. Clinical trials comparing microsurgical, laparoscopic and open varicocelectomies were included. Statistical analysis was managed using Review Manager 5.3. Seven clinical trials of 1,781 patients were included. T...
Source: Reproductive Biology - March 17, 2017 Category: Reproduction Medicine Authors: Yuan R, Zhuo H, Cao D, Wei Q Tags: Syst Biol Reprod Med Source Type: research

Embryogenesis Explained: Prolegomenon.
PMID: 28301254 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - March 17, 2017 Category: Reproduction Medicine Authors: Gordon NK Tags: Syst Biol Reprod Med Source Type: research

The cell state splitter: Embryogenesis Explained: A review by David MillerGordon, Natalie K., and Gordon, Richard. Embryogenesis Explained. World Scientific Publishing Co., Singapore, 2016. 784 pages. ISBN 978-981-4350-48-8.
PMID: 28301255 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - March 17, 2017 Category: Reproduction Medicine Authors: Miller D Tags: Syst Biol Reprod Med Source Type: research

Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications.
Abstract The mammalian sperm contains a highly unique and specialized epigenetic landscape that offers a great degree of interesting research opportunities. One key discriminating feature of the mature sperm epigenome is that it, in theory, represents both remnant marks used throughout spermatogenesis to generate sperm cells competent to perform their function, but also marks that appear to be useful beyond fertilization. Key questions must be asked about the utility of these marks and the multiple purposes that may be served. It is this unique epigenetic landscape that has driven some labs to begin to study the l...
Source: Reproductive Biology - March 17, 2017 Category: Reproduction Medicine Authors: Jenkins TG, Aston KI, James ER, Carrell DT Tags: Syst Biol Reprod Med Source Type: research

Gp91phox NADPH oxidase modulates litter size by regulating mucin1 in the uterus of mice.
In this study, we examined the influence of ROS produced by gp91phox activity on the number of births using C57BL/6j (control) and gp91phox-knockout (gp91phox(-/-)) mice. The number of births in gp91phox(-/-) mice was found to be lower than that in control mice. We observed sequential increases in gp91phox, ROS, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3), caspase-1, and interleukin-18 (IL-18), followed by increased expression of mucin1 (MUC1), in control mice. However, none of these markers were upregulated in gp91phox(-/-) mice. In addition, in control mice administered IL...
Source: Reproductive Biology - March 17, 2017 Category: Reproduction Medicine Authors: Hiramoto K, Yamate Y, Sato EF Tags: Syst Biol Reprod Med Source Type: research

MALDI mass spectrometry reveals that cumulus cells modulate the lipid profile of in vitro-matured bovine oocytes.
; Rosa-E-Silva AC Abstract The influence of cumulus cells (CC) on the lipid profile of bovine oocytes matured in two different lipid sources was investigated. Cumulus-oocyte complexes (COC) or denuded oocytes (DO) were matured in tissue culture medium (TCM) supplemented with fetal bovine serum (FBS) or serum substitute supplement (SSS). Lipid profiles of TCM, serum supplements, immature CC and oocyte (IO), and in vitro-matured oocytes from COC and DO were then analyzed by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) and submitted to partial least squares-discriminant analysis (PLS-DA). ...
Source: Reproductive Biology - March 17, 2017 Category: Reproduction Medicine Authors: Vireque AA, Tata A, Belaz KR, Grázia JG, Santos FN, Arnold DR, Basso AC, Eberlin MN, Silva-de-Sá MF, Ferriani RA, Sá Rosa-E-Silva AC Tags: Syst Biol Reprod Med Source Type: research

Mesenchymal stem cell-derived angiogenin promotes primodial follicle survival and angiogenesis in transplanted human ovarian tissue.
CONCLUSION: Our results indicate that ANG plays a critical role in regulating angiogenesis and follicle survival in xenografted human ovarian tissues. Our findings provide important insights into the molecular mechanism by which MSCs promote angiogenesis and follicle survival in transplanted ovarian tissues, thus providing a theoretical basis for their further application. PMID: 28274269 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - March 9, 2017 Category: Reproduction Medicine Authors: Zhang Y, Xia X, Yan J, Yan L, Lu C, Zhu X, Wang T, Yin T, Li R, Chang HM, Qiao J Tags: Reprod Biol Endocrinol Source Type: research

An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism.
CONCLUSIONS: Corifollitropin alfa 150 μg administrated every other week combined with twice-weekly hCG for 52 weeks increased testicular volume significantly, and induced spermatogenesis in>75% of men with HH who had remained azoospermic after hCG treatment alone. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01709331 . PMID: 28270212 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - March 7, 2017 Category: Reproduction Medicine Authors: Nieschlag E, Bouloux PG, Stegmann BJ, Shankar RR, Guan Y, Tzontcheva A, McCrary Sisk C, Behre HM Tags: Reprod Biol Endocrinol Source Type: research

Chronic endometritis modifies decidualization in human endometrial stromal cells.
CONCLUSION: Our data suggests that CE modifies decidualization of human ESC through untuning the function of sex steroid hormone receptor. PMID: 28259137 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - March 4, 2017 Category: Reproduction Medicine Authors: Wu D, Kimura F, Zheng L, Ishida M, Niwa Y, Hirata K, Takebayashi A, Takashima A, Takahashi K, Kushima R, Zhang G, Murakami T Tags: Reprod Biol Endocrinol Source Type: research

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women.
Abstract BACKGROUND: To investigate the effect of fertility stress on endometrial and subendometrial blood flow among infertile women. METHODS: This case-control study was conducted in The First Affiliated Hospital of Zhengzhou University. The fertility problem inventory (FPI) was adopted to evaluate fertility stress. Three-dimensional power Doppler ultrasonography (3D PD-US) was performed during the proliferative phase of the menstrual cycle (days 5-11) to measure endometrial thickness, pattern, endometrial and subendometrial volume (V), the vascularization index (VI), the flow index (FI) and the vasculariza...
Source: Reproductive Biology - March 4, 2017 Category: Reproduction Medicine Authors: Dong Y, Cai Y, Zhang Y, Xing Y, Sun Y Tags: Reprod Biol Endocrinol Source Type: research

Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions.
CONCLUSIONS: Expression of pluripotency factors SOX2, NANOG and OCT4 increased in a mouse model of LPS-induced acute uterine injury. NANOG peaked earlier followed by the other two factors before returning to baseline levels. NANOG but not SOX2 and OCT4 expression was overexpressed in the endometrium of women with IUA. They may be involved in the formation or restoration of IUA, and their roles in pathogenesis of IUA need to be further studied. PMID: 28253866 [PubMed - in process] (Source: Reproductive Biology)
Source: Reproductive Biology - March 3, 2017 Category: Reproduction Medicine Authors: Xiao L, Song Y, Huang W, Yang S, Fu J, Feng X, Zhou M Tags: Reprod Biol Endocrinol Source Type: research

Lymphedema after treatment for endometrial cancer - A review of prevalence and risk factors.
ede P Abstract Lymphedema is one of the least studied complications of cancer treatment and a chronic condition with a substantial impact on health-related quality of life (HQoL). Lymphedema of the legs (LLL) constitutes a common adverse side effect of lymphadenectomy LA in gynecologic cancer treatment. Primary treatment of endometrial cancer (EC) comprises hysterectomy and bilateral salpingo-oophorectomy. Pelvic and para-aortic lymphadenectomy is recommended in prognostic high risk groups of EC. This review summarizes the published literature concerning the prevalence of LLL after treatment for EC, methods used f...
Source: Reproductive Biology - February 22, 2017 Category: Reproduction Medicine Authors: Lindqvist E, Wedin M, Fredrikson M, Kjølhede P Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Subsequent pregnancy outcome of tubal ectopic pregnancies treated by methotrexate and salpingectomy.
PMID: 28238473 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - February 20, 2017 Category: Reproduction Medicine Authors: Park EH, Mohammadi-Zaniani G, Pronin S, Elderfield CH, Duncan WC Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Association study between GAS6 gene polymorphisms and risk of preeclampsia in Chinese population.
CONCLUSION: Our data suggest that a TT genotype at +1332C/T polymorphism might be associated with decreased risk for preeclampsia, but the 834+7G/A polymorphism is not associated with the disorder, in the Chinese population. PMID: 28242471 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - February 20, 2017 Category: Reproduction Medicine Authors: Ye L, Guan L, Fan P, Liu X, Liu R, Chen J, Zhu Y, Wei X, Liu Y, Bai H Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research

Gonadotropin-releasing hormone agonist (GnRHa) trigger - State of the art.
Abstract GnRH agonist (GnRHa) trigger for final oocyte maturation in GnRH antagonist co-treated IVF/ICSI cycles significantly reduces the risk of ovarian hyperstimulation syndrome (OHSS). GnRHa trigger followed by modifications of the standard luteal phase support (modified luteal phase support) secures fresh transfer in the majority of patients with excellent reproductive outcomes. In freeze all cycles (segmented cycles) GnRHa trigger allows oocyte retrieval with a minimal risk of early onset OHSS and good reproductive outcomes in subsequent frozen thaw cycles. Overall, two different luteal phase support strategi...
Source: Reproductive Biology - February 16, 2017 Category: Reproduction Medicine Authors: Dosouto C, Haahr T, Humaidan P Tags: Reprod Biol Source Type: research

The role of estrogen receptor subtypes for induction of delayed effects on the estrous cycle and female reproductive organs in rats.
Abstract It has been reported that neonatal exposure to estrogens at relatively low doses can induce early onset anovulation as a delayed effect in female rats. Dysfunction of kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) was proposed to be a trigger for this effect. To determine the roles of estrogen receptor (ER) subtypes in the induction of delayed effects, we conducted a series of experiments using Donryu rats to examine whether neonatal injection of an ERα agonist (PPT), an ERβ agonist (DPN) or an ERα antagonist (ICI) could induce delayed effects. Also, involvement of...
Source: Reproductive Biology - February 16, 2017 Category: Reproduction Medicine Authors: Takahashi M, Ichimura R, Inoue K, Morikawa T, Kuwata K, Watanabe G, Yoshida M Tags: Reprod Biol Source Type: research