Changes in Borg scale for resistance training and test of exercise tolerance in patients undergoing allogeneic hematopoietic stem cell transplantation
AbstractPurposeWe aimed to investigate the relationship between Borg scale and intensity of resistance training in patients who had undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, the relationship between Borg scale, heart rate (HR), and intensity of exercise tolerance test was also studied.MethodsThe study included 28 patients (19 men and 9 women) who had undergone allo-HSCT between June 2015 and February 2017. Their knee extension strengths and exercise tolerances were evaluated. Patients were asked to grade between 0 and 10 on Borg scale based on the level of difficulty experienced...
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Multidrug-resistant bacterial microorganisms (MDRO) in end-of-life care: development of recommendations for hospitalized patients using a mixed-methods approach
ConclusionThe recommendations summarize the perspectives of individuals and groups affected by MDRO at the end of life and provide practical guidance for clinical routine. Further dissemination and implementation requirements are discussed and should contain the evaluation of the knowledge, views, worries, and anxieties of the target groups. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma
ConclusionsThe addition of doxycycline to standard prophylaxis with ciprofloxacin seems to reduce the number of NF episodes and documented bacterial infections in patients with MM undergoing ASCT, without increasing rate of serious complications. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

The cultural expression of spiritual distress in Israel
ConclusionsSpecially designed interventions to reduce spiritual distress should address the expressions of the distress specific to that culture. Studies of the efficacy of spiritual care can examine the extent of spiritual distress in general or of its specific cultural expressions. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

A randomized, open-label non-inferiority study to compare palonosetron and ondansetron for prevention of acute chemotherapy-induced vomiting in children with cancer receiving moderate or high emetogenic chemotherapy
AbstractBackgroundChemotherapy-induced vomiting is a common adverse effect of cancer treatment. We assessed the non-inferiority of palonosetron versus ondansetron in prevention of acute chemotherapy-induced vomiting in children with cancer in 2 –18 years of age.MethodsIn this single-center, open-label, randomized study, children receiving moderate and high emetogenic chemotherapy were assigned to get either ondansetron or palonosetron in addition to other antiemetic prophylaxis. The primary efficacy endpoint was the proportion of children with complete response during the acute phase of the first on-study chemot...
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

The impact of dietary regimen compliance on outcomes for HNSCC patients treated with radiation therapy
ConclusionLaryngeal and oropharyngeal cancer patients treated with definitive RT who are compliant with regular dietetic counseling and contact appear to have improved outcomes.Trial registrationNot applicable (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Echocardiography has low utility in cancer patients with Staphylococcus aureus bacteraemia: findings from a retrospective study
ConclusionIE is infrequent in cancer patients with uncomplicated SAB and no risk factors for IE. Performing echocardiography routinely in all cancer patients with SAB rarely alters diagnosis or affects antibiotic management and therefore should be reserved for patients with specific risk factors. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Development of esthetic prosthesis for a patient with severe stigmatizing facial lesions due to cancer: a pilot study
ConclusionWe have found that the application of this new technology greatly improves the social interaction of patients with deformities due to surgical interventions. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Patients ’ Experience of Living with Cancer-associated thrombosis in Spain (PELICANOS)
ConclusionThe distress experienced by patients with CAT is not isolated to the UK alone but is similar in Spanish patients as well. The patient information provided regarding LMWH injections is important, but there is a need to for patients and their families to be given additional information about CAT itself and future prognosis. CAT also has a profound impact on the patient ’s family who has similar support needs. It appears that there are several commonalities between UK and Spanish patients, as well as specific local issues. This study justifies expansion of the sampling to other countries. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Safety and comfort of domestic bortezomib injection in real-life experience
We report our evaluations upon safety and efficacy of domestic subcutaneous bortezomib in elderly and frail patients candidate to bortezomib-melphalan-prednisone (VMP) regimen. We confirmed that overall incidence of adverse events, including peripheral neuropathy, was low, and in no case required admission to emergency service, contributing to reduce the rate of therapy discontinuation. These results confirm the effectiveness and safety of subcutaneous bortezomib, in a real-life-experience, and define a new possibility of safe auto-administration in a comfortable domestic setting. We suggest that domestic treatment can sig...
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Investigation of the optimal duration of bed rest in the supine position to reduce complications after lumbar puncture combined with intrathecal chemotherapy: a multicenter prospective randomized controlled trial
ConclusionsThe overall results support that the optimal time interval for bed rest in the supine position after intrathecal chemotherapy is 8  h. This trial is registered with the Chinese Clinical Trial Registry (number ChiCTR-IOR-17011671). (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Examining variation across treatment clinics in cancer patients ’ psychological outcomes: results of a cross sectional survey
ConclusionsPsychological outcomes were not found to vary between clinics. Other sources of variation including patient characteristics may over-ride between-clinic variability, if it exists. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Comparing a genetic and a psychological factor as correlates of anxiety, depression, and chronic stress in men with prostate cancer
ConclusionsEach of these two factors may provide valuable information regarding the vulnerability of PCa patients to anxiety, depression, or chronic stress. Suggestions are made for their inclusion in clinical settings. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Palliative sedation in advanced cancer patients hospitalized in a specialized palliative care unit
ConclusionsPalliative sedation is a valid therapeutic option for refractory symptoms causing suffering. The results correspond to international reports and guidelines, which suggests that PS is tailored to the needs of the individual patient while maintaining a high scientific standard, even in a context where PC is under development. However, further development of strategies and clear indications towards the use of PS in Colombia are needed, given its still scarce use. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Heart rate variability for rapid risk stratification of emergency patients with malignant disease
ConclusionDeceleration capacity of heart rate is suitable for rapid risk assessment of emergency patients with malignant diseases. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Metastatic epidural spinal cord compression: does timing of surgery influence the chance of neurological recovery? An observational case-control study
ConclusionMESCC management is challenge for spine surgeons and may represent an oncologic emergency and if not promptly diagnosed can lead to a permanent neurological damage. According to this study, there is no difference in the chance of neurological recovery if surgery is performed within or after 24  h the admission to hospital, but there is a greater rate of early post-operative complications when surgery is performed within 24 h from the admission to the hospital. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

A cohort study on protocol-based nurse-led out-patient management of post-chemotherapy low-risk febrile neutropenia
ConclusionOut-patient management of patients with low-risk febrile neutropenia is effective and safe through implementation of a structured protocol with joint inputs and engagement from clinicians, oncology nurses, and patients. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Bleeding frequency and characteristics among hematologic malignancy inpatient rehabilitation patients with severe thrombocytopenia
AbstractObjectiveTo identify the frequency and characteristics of bleeding complications during acute inpatient rehabilitation of hematologic malignancy patients with severe thrombocytopenia.DesignRetrospective descriptive analysis.SettingComprehensive cancer center acute inpatient rehabilitation unit.ParticipantsConsecutive hematologic malignancy patients with a platelet count of less than or equal to 20,000/microliter ( μL) on the day of acute inpatient rehabilitation admission from 1/1/2005 through 8/31/2016.InterventionsMedical records were retrospectively analyzed for demographic, laboratory, and medical data. Pati...
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study
AbstractBackgroundClostridium difficile infection (CDI) is the most common hospital-acquired infection. Unfortunately, genes that identify CDI-susceptible patients have not been well described. We performed a genome-wide association study (GWAS) to determine genetic variants associated with the development of CDI.MethodsA cohort study of Caucasian patients undergoing autologous stem cell transplantation for multiple myeloma was performed. Patients were genotyped using Illumina ® Whole Genome Genotyping Infinium chemistry. We then compared CDI-positive to CDI-negative patients using logistic regression for baseline clin...
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Can early palliative care with anticancer treatment improve overall survival and patient-related outcomes in advanced lung cancer patients? A review of the literature
The original version of this article unfortunately incorrectly captured the title for Table  2. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 28, 2018 Category: Cancer & Oncology Source Type: research

Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer
ConclusionsParticipating in an exercise-based multidisciplinary rehabilitative intervention reduces isolation and helps oesophago-gastric cancer survivors to safely negotiate their physical, emotional and social needs as they move further down the path of recovery. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Hepatoprotective effect of N-acetylcysteine in trabectedin-induced liver toxicity in patients with advanced soft tissue sarcoma
ConclusionThis explorative study suggests that NAC can have a hepatoprotective activity in patients receiving trabectedin allowing to maintain an adequate dose intensity and continuative administration in patients with impaired liver and renal function or developing treatment-induced hepatotoxicity. A prospective randomized trial is warranted. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Optimal cancer care: what essential elements of care would help haematological cancer patients obtain and understand information about their disease and its treatment and impact?
ConclusionsFurther research is needed to determine ways of meeting the preferences of haematological cancer patients and determining the associated impact on patient outcomes. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Response to “Identification of appropriate and potentially avoidable emergency department referrals in a tertiary cancer care center” by Duflos et al.
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Management of radiation-induced mucosal necrosis with photobiomodulation therapy
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Patterns of oral and dental care education and utilization in head and neck cancer patients
ConclusionsThere is a general lack of consistency with how, when, and from whom oral cancer patients receive their oral health education. It is likely that this contributes to insufficient education resulting in high levels of patient dissatisfaction with their oral care. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Patterns of bisphosphonate treatment among patients with multiple myeloma treated at oncology clinics across the USA: observations from real-world data
ConclusionsReal-world data from US oncology practices indicate that many patients with multiple myeloma may not receive optimal therapy for bone disease, particularly those with renal impairment. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Spiritual well-being associated with personality traits and quality of life in family caregivers of cancer patients
This study focuses on the spiritual well-being (SWB) of the family caregivers of cancer patients, examining the relationship with personality traits and quality of life (QoL) in palliative and curative care settings.MethodsAll participants (n = 199) underwent the following self-report questionnaires: the Structural Analysis of Social Behavior (SASB)-Form A, the SWB Index, and the Medical Outcomes Study Short Form (SF-36). SWB scores were dichotomized at a cutoff corresponding to the 75th percentile. Statistical analysis: Student’st test or by χ squared tests to compare high and low SWB and multivari...
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

The impact of UGT2B7 C802T and CYP3A4*1G polymorphisms on pain relief in cancer patients receiving oxycontin
ConclusionThe palliative effect of oxycontin is better in patients withUGT2B7 802CC than in those with802TT.CYP3A4*1G SNP is unlikely to affect pain relief efficacy of oxycontin. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Conventional versus pigtail chest tube —are they similar for treatment of malignant pleural effusions?
DiscussionThese findings suggest that pigtail chest tube can be an alternative on palliation, with no compromise in pleurodesis performance. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Axillary web syndrome assessment using a self-assessment questionnaire: a prospective cohort study
AbstractBackgroundSurgical procedure for breast cancer is not without its side effects and one such side effect is axillary web syndrome (AWS), characterized by palpable fibrotic-like cords in the operated arm. As physical evaluation is the only gold standard method used, our study aims to assess the incidence and early detection of AWS with a self-assessment questionnaire.MethodsFrom July 2013 to July 2014, 370 breast cancer patients were enrolled. AWS incidence was 51.1%, with 94.1% onset in the first 4  weeks after surgery; 43.5% of the patients did not recover in the first 8 weeks. Univariate analysis showed that BMI (P 
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Perception of need for nutritional support in advanced cancer patients with cachexia: a survey in palliative care settings
ConclusionsPatients with cancer cachexia expressed a greater need for nutritional support. They wished to receive nutritional support from medical staff when they become unable to take sufficient nourishment orally and the negative impact of cachexia becomes apparent. Most patients wished to receive parenteral nutrition and hydration. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors
AbstractPurposeChemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors.MethodsPrior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants inABCB1 (rs1045642) andHTR3B (rs45460698) as well asCYP2D6 activity score. The M.D. Anders...
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Maximizing patient adherence to prehabilitation: what do the patients say?
ConclusionsThese findings highlight the need to make prehabilitation programs more patient-centered. This is critical when designing more effective therapeutic strategies tailored to meet patients ’ specific needs while overcoming program non-adherence. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

25(OH) vitamin D deficiency in lymphoid malignancies, its prevalence and significance. Are we fully aware of it?
AbstractIntroductionVitamin D has a role in cellular differentiation, proliferation, apoptosis, and angiogenesis and therefore is studied as a prognostic factor in cancer. The aim of our study was to assess the prevalence and significance of 25(OH)D deficiency in patients with lymphoid malignancies.MethodologyBetween January 2014 and June 2016 at the Clinic for Hematology, Clinical Center of Serbia, Belgrade, the pretreatment serum level of 25(OH)D was determined in 133 (62 women/71 men, median age 58 (18 –84) years) previously untreated patients with lymphoid malignancy using a chemiluminescent immunoassay. From the...
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Use of compression garments by women with lymphoedema secondary to breast cancer treatment
ConclusionThe prescription of compression garments for lymphoedema is highly varied and may be due to lack of underpinning evidence to inform treatment. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

TOXICAN: a guide for grading dermatological adverse events of cancer treatments
ConclusionThe objective of our practical guide is to facilitate the use of the CTCAE for recognizing and grading dermatological toxicity of cancer treatments in order to provide optimal guidance for therapeutic adaptations. Its impact on clinical practice remains to be evaluated. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Network analysis of drug-related problems in hospitalized patients with hematologic malignancies
ConclusionsDRPs were mainly related to medications for supportive care. More attention should be paid to interactions of drugs used for acid-related disorders, dose adjustment of antibacterials, and omission of antiemetics in hospitalized patients with hematologic malignancy. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Response to the response by Lahbib et al. to “Identification of appropriate and potentially avoidable emergency department referrals in a tertiary cancer care center” by Duflos et al.
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Management of radiation-induced mucosal necrosis with photobiomodulation therapy
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: research

Integrative medicine and the oncology patient: options and benefits
AbstractCancer is a major public health problem, and cancer patients and survivors face many physical and emotional challenges after the initial diagnosis, through treatment, and in the post-treatment period. Different integrative medicine (IM) modalities can be used to mitigate some of the physical issues that originate from the cancer itself or the treatment and to promote well-being and emotional health. Here, we discuss how an IM Department can function in a hospital system, particularly with regard to oncology patients, the modalities appropriate for oncology patients, how these modalities can benefit this patient pop...
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

A pilot investigation on impact of participation in a long-term follow-up clinic (LTFU) on breast cancer and cardiovascular screening among women who received chest radiation for Hodgkin lymphoma
AbstractBackgroundWomen treated with chest radiation for Hodgkin lymphoma (HL) are at significantly increased risk of breast cancer and cardiovascular disease. HL survivors are recommended to have annual dual screening with mammogram (MMG) and breast magnetic resonance imaging (MRI). They are also recommended to undergo echocardiogram (echo) 5  years after completion of radiation. We performed a pilot study to characterize the women who are and are not receiving proper dual screening for breast cancer and baseline echo, and to examine the impact of a LTFU clinic consultation on screening.MethodsA retrospective chart r...
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

New frontier: cancer pain management clinical fellowship
AbstractCancer pain is a multi-dimensional experience, varies from person to person both physically and psycho-socially, and impacts all aspects of the patients ’ quality of life. Majority of patients with an advanced or metastatic cancer will experience pain. It is estimated that as many as half of cancer patients are under-treated and as many as 20% experience pain refractory to the conventional WHO ladder of pain management. The McGill University Healt h Centre (MUHC) Cancer Pain Clinic (CPC) was created to meet the needs of those patients with a diagnosis of cancer whose pain had become a main symptom and those w...
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Oral health impact profile of head and neck cancer patients after or before oncologic treatment: an observational analytic case-control study
The objective of this study was to investigate the impact of oral health on the quality of life of patients with head and neck cancer (HNC) before and after oncologic treatment.MethodsForty cancer-free individuals (Cf group) and 40 HNC patients (Hnc group) were included in this study. Hnc group was also divided into two subgroups: Hnc 1 (pre-cancer therapy,n = 20) and Hnc 2 (post-cancer therapy,n = 20). Participants were asked to complete a short form of Oral Health Impact Profile (OHIP-14). The results were statistically analyzed with the multivariate analysis of variance with post-hoc Scheff&e...
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses
ConclusionsClinicopathological features and survival outcomes in the PBM-treated patients were similar to previously published data for conventional treatments in patients with advanced OSCC. In this study, prophylactic use of PBM therapy did not impact treatment outcomes of the primary cancer, recurrence or new primary tumors, or survival in advanced OSCC patients. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Quality of life trajectories during the first year following hematopoietic cell transplantation: an inception cohort study
ConclusionsQOL changes dramatically following HCT. People report more interference with valued activities and interests after 1  year than survivors of other cancers, but depressive symptoms are not higher. Positive and negative affect are equivalent to healthy community residents. Continued involvement in psychologically meaningful activities may preserve QOL. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Sestrin family of genes and their role in cancer-related fatigue
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Impact of opioid use on health care utilization and survival in patients with newly diagnosed stage IV malignancies
We examined these possibilities in a large cohort of patients diagnosed with ten common advanced malignancies.MethodsWe identified 1386 newly diagnosed patients with stage IV non-hematologic malignancies from 2005 to 2013 and ascertained opioid utilization within 90  days of starting anti-cancer treatment using electronic medical record and tumor registry data. Opioid utilization was stratified into low opioid (LO;
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Financial and socio-economic factors influencing pre- and post-cancer therapy oral care
ConclusionsDental attendance decreases by a statistically and clinically significant amount both during and after cancer therapy despite guideline recommendations encouraging dental referral and monitoring for many types of cancer therapy. Attendance at dental appointments during cancer therapy is associated with improved survival, which is likely due to a combination of direct and indirect effects. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Incidence of infusion hypersensitivity reaction after withholding dexamethasone premedication in early breast cancer patients not experiencing two previous cycles of infusion hypersensitivity reaction for weekly paclitaxel chemotherapy
ConclusionWithholding dexamethasone premedication in non-experiencing HSR patients after two previous cycles of weekly paclitaxel administration was safe and did not impact the higher incidence of HSR. A discontinuing dexamethasone protocol should be recommended generally in these patients, especially those with a high risk for steroid-induced side effects. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research