Neu-horizons: neuroprotection and therapeutic use of riluzole for the prevention of oxaliplatin-induced neuropathy —a randomised controlled trial
ConclusionThis study is the first to provide an objective clinical investigation of riluzole in oxaliplatin-induced peripheral neuropathy employing both functional and neurophysiological measures. Although the recruitment target was not reached, the results do not show any benefit of riluzole in minimising neuropathy and may suggest that riluzole worsens neuropathy associated with oxaliplatin treatment. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Effects of preoperative dental examination and oral hygiene instruction on surgical site infection after hepatectomy: a retrospective study
ConclusionsPreoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study
ConclusionOur findings emphasise a gap in information and supportive care for family donors and the need for a protocol specifically designed to inform and support family donors before, during and after HSC donation. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Post-mastectomy breast reconstruction: reducing the disparity through educational outreach to the underserved
This study aimed to determine whether physician led, community-based educational symposium improves understanding of breast cancer care and breast reconstruction in underserved populations.MethodsAnnual educational symposiums were held between 2017 and 2019 in underserved communities in the greater Philadelphia area. The symposium consisted of a series of short lectures on breast health, cancer screening, surgical management and reconstruction, patient testimonials, a Q&A panel, and an exhibitor fair. Attendees were given pre- and post-symposium surveys that evaluated knowledge of breast cancer care and reconstruction ...
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Pain characteristics in medication-related osteonecrosis of the jaws
ConclusionsPain from infection and inflammation often accompanies MRONJ. The presence of pain is correlated with longer BMAs pre-therapy and if surgery preceded the MRONJ. Persistency of the mild pain together with a resistance to common antimicrobial treatment, although not complete, is a feature that MRONJ pain shares with neuropathic- “like” pain, and requires further study and consideration during treatment. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Long-term impact of bone-modifying agents for the treatment of bone metastases: a systematic review
ConclusionsEvidence informing the use of BMA beyond 2  years is heterogeneous and based on retrospective analysis. Prospective randomized studies with greater emphasis on quality of life are needed.PROSPERO registration numberCRD42019126813 (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

The impact of cancer on theory of planned behavior measures and physical activity levels during the first weeks following cancer diagnosis in children
ConclusionThe findings of this study highlight the negative impacts of cancer on children ’s TPB measures, self-reported fitness, and self-esteem in the physical domain and self-reported MVLPA levels over 4 to 6 weeks following the diagnosis. These findings help to better understand the effect of cancer diagnosis on children’s physical activity behavior. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Late complications and quality of life assessment for survivors receiving allogeneic hematopoietic stem cell transplantation
AbstractPurposeThe survival rates of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) have improved. However, HSCT can induce significant long-term complications. Therefore, we investigated the late complications and risk factors for quality of life (QOL) post-HSCT.MethodsWe retrospectively analyzed 67 adult survivors over 2  years after HSCT between 2015 and 2018 at Ulsan University Hospital, Ulsan, Korea. The survey data including FACT-BMT, Hospital Anxiety and Depression Scale, and NCCN Distress Thermometer were collected as patient-reported outcomes using a tablet PC during a routine p...
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Reply to: “Discussing sexuality in cancer care: towards personalized information for cancer patients and survivors”
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Pre-post analysis of a social capital-based exercise adherence intervention for breast cancer survivors with moderate fatigue: a randomized controlled trial
Tables  1, 2, and 3 are incorrect. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Intestinal occlusion by gynecological cancers treated by percutaneous endoscopic gastrostomy and lanreotide: an Aviano National Cancer Institute experience
AbstractThe Commentary reports on our experience in Centro di Riferimento Oncologico IRCCS Aviano about the integrated and combined treatment with percutaneous endoscopic gastrostomy and lanreotide in patients with bowel obstructions by ovarian cancer and peritoneal carcinomatosis. We treated patients with gynecological cancers and bowel obstruction with percutaneous endoscopic gastrostomy and, when patients were partially responsive, with lanreotide. We registered a constant overall benefit for the quality of life and for the control of symptoms, which is very important especially during the home care follow-up of termina...
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Rapid deployment of virtual mind-body interventions during the COVID-19 outbreak: feasibility, acceptability, and implications for future care
We describe the rapid deployment of remotely delivered mind-body services to people with cancer during COVID-19, rates of participation, and acceptability from patients ’ perspectives.MethodsEligible participants were patients with cancer age ≥ 18 years enrolled in a single academic cancer center’s online patient portal. Interventions included mind-body group therapy sessions in fitness, meditation, yoga, dance, tai chi, and music delivered using Zoom video conferencing. Sessions were 30–45 min and led by an integrative medicine cl inician. Following each session, participants were asked to complete a ...
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

In reply to: “A COVID-19 screening tool for oncology telephone triage”
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Teleprehabilitation during COVID-19 pandemic: the essentials of “what” and “how”
AbstractIn view of the COVID-19 pandemic and recent global events, the healthcare system and its services have been negatively affected, contributing towards extensive surgical backlogs. Oncological surgical candidates have been the most impacted by these changes and recommended self-isolation practices, which could result in emotional distress, sedentary behavior, and poor lifestyle habits. Preoperative supportive intervention, prehabilitation, has been proven to improve patients ’ functional status and clinical trajectories. Presently, there is a critical need for prehabilitation to optimize patient health, as they...
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Evaluation of the correlation between side effects to oral mucosa, salivary glands, and general health status with quality of life during intensity-modulated radiotherapy for head and neck cancer
Data incorrect for the results section and table 1. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 28, 2020 Category: Cancer & Oncology Source Type: research

Diagnosed with a common cancer at an unusual age: causal attributions of survivors of adolescent and young adult colorectal cancer
This study aims to examine the causal attributions of CRC in AYA patients, compare these with middle-aged and older adults CRC patient groups and explore the association between causal attributions and psychological distress.MethodsTwo cross-sectional questionnaire studies were conducted among CRC survivors diagnosed between 1998 and 2007 using the population-based PROFILES registry. Three groups were defined by age at diagnosis: AYA (18 –39 years;n = 67), middle-aged (40–70 years;n = 1993) and older adult survivors (70+ years;n = 1922). Causal attribut...
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Feasibility and acceptability of a game-based symptom-reporting app for children with cancer: perspectives of children and parents
ConclusionStudy results support the preliminary feasibility and acceptability of the app. Children ’s and parents’ responses supported the developmental relevance of the app and its role in enhancing the child’s autonomy and serving as an outlet for creativity. Future directions include optimizing the child user’s experience and investigating the app’s role as a resource to enhance shar ed decision-making for symptom management. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Cross-sectoral video consultations in cancer care: perspectives of cancer patients, oncologists and general practitioners
ConclusionOverall, multidisciplinary video consultations between cancer patient, general practitioner and oncologist were feasible in daily clinics. Initial barriers to address were technical issues and seamless planning. Patients reported high satisfaction, patient centredness and clarity of roles. General practitioners and oncologists were overall positive regarding role clarification and continuity, although less pronounced than patients.Trial registrationwww.clincialtrials.gov, NCT02716168. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Patient interactive digital support for women with adjuvant endocrine therapy in order to increase compliance and quality of life
ConclusionThe app was perceived easy to use and of support in every-day life of breast cancer survivors. How to best integrate electronically collected patient reported outcome measures in clinical routine needs to be further studied, and future research will show if it will be cost-effective in terms of better health outcome and less resource use. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Primary care physician ’s confidence and coordination regarding the survivorship care for older breast cancer survivors
ConclusionParticipants indicated that PCP confidence in providing survivorship care is lacking and that lack of training, infrequent communication with oncologists, and underutilization of SCPs may contribute to this lack of confidence. These findings provide insight into the possible need for a well-defined shared care model, which has been encouraged but not always a routine part of survivorship care in various practice settings. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Fear of analgesic side effects predicts preference for acupuncture: a cross-sectional study of cancer patients with pain in the USA
ConclusionAcupuncture may be a preferable treatment option among cancer patients at risk of inadequately controlled pain due to fear of analgesic side effects. Evidence-based integration of acupuncture and analgesics, guided by patient treatment preferences, represents an essential aspect of patient-centered care and has potential to address unmet cancer pain management needs. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Going beyond (electronic) patient-reported outcomes: harnessing the benefits of smart technology and ecological momentary assessment in cancer survivorship research
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Comparing the roles of social context, networks, and perceived social functioning with health-related quality of life among self-reported rural female cancer survivors
ConclusionsOur findings suggest a rich diversity of social context and networks among rural female cancer survivors, and social functioning is particularly important for mental health-related QOL. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Risk factors and the utility of three different kinds of prediction models for postoperative fatigue after gastrointestinal tumor surgery
ConclusionsMore attention should be paid on specific patients after gastrointestinal tumor surgery. BP-ANN is a powerful mathematical tool that could predict POF exactly. It may be used as a noninvasive screening tool to guide clinicians for early identification of high-risk patients and grading interventions. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Lifestyle among long-term survivors of cancers in young adulthood
ConclusionA large proportion of long-term YACSs do not meet the lifestyle guidelines for PA, BMI, and/or smoking. Non-adherence to guidelines is associated with several late effects and/or comorbidities that should be considered when designing lifestyle interventions for YACSs. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Facilitators and barriers to shared primary and specialist cancer care: a systematic review
ConclusionRecommendations for practice and policy were generated based on review findings that may support broader implementation of shared cancer care. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Influencing factors of cardiorespiratory fitness in allogeneic stem cell transplant candidates prior to transplantation
AbstractPurposeCardiorespiratory fitness (CRF) seems to be prognostic prior to allogeneic stem cell transplantation (allo-HSCT). Influencing factors of CRF in allo-HSCT candidates have not been studied so far. Aim was to identify potentially influencing factors on CRF.MethodsTo assess CRF, a maximal cardiopulmonary exercise test (CPET) was performed on average 2.6  ± 7.2 days prior to admission. A regression analysis was conducted, with the following predictors: gender, age, body mass index (BMI), time between last therapy and allo-HSCT (t_Therapies), number of cardiotoxic therapies (n_Cardiotox),...
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Impact of cardiovascular comorbidities on inpatient mortality in patients hospitalized with neutropenic fever
ConclusionAtrial fibrillation and congestive heart failure were associated with higher inpatient mortality in patients with neutropenic fever. Identifying the risk factors for increased mortality in patients with neutropenic fever is important for risk stratification and guiding clinicians in taking therapeutic decisions in this set of patients. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Hematological malignancies in Polish population: what are the predictors of outcome in patients admitted to Intensive Care Unit?
ConclusionsWe have demonstrated that ICU and in-hospital mortalities among patients with hematological malignancies are still poor, but easier access to the intensive care unit and close cooperation between hematologists and intensivists may improve outcomes. We have found that acute failure of key organs (acute respiratory failure, end-stage renal failure requires renal replacement therapy) and length of ICU stay (but probably no comorbidities and illness severity) may have impact on mortality (both ICU and in-hospital). (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102
AbstractPurposeTo evaluate the efficacy of testosterone supplementation for improving aromatase inhibitor musculoskeletal symptoms (AIMSS).MethodsPostmenopausal women experiencing moderate-to-severe arthralgias while taking adjuvant aromatase inhibitors for breast cancer were enrolled in this trial. Initially, patients were randomly allocated to receive either a subcutaneous testosterone pellet versus a placebo pellet. Due to slow accrual, the protocol was modified such that additional participants were randomized to receive either a topical testosterone gel or a placebo gel. Changes in patient-reported joint pain were com...
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Letter to the editor: re Lu et al.
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Unique needs of childhood cancer survivors during the COVID-19 pandemic
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

In reply to “could acupuncture be a treatment option for cancer patients with attitudinal barriers to pharmacological pain management?” by Kako, Kajiwara, and Kobayashi
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Could acupuncture be a treatment option for cancer patients with attitudinal barriers to pharmacological pain management?
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research

Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological Complications Study Group
The objective of this review is to provide oncology clinicians with an overview of CRCI in the context of adults with non-central nervous system cancers, with a particular focus on current approaches in its identification, assessment, and management. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 24, 2020 Category: Cancer & Oncology Source Type: research

Response: Author reply
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 24, 2020 Category: Cancer & Oncology Source Type: research

Emerging challenges in the evaluation of fever in cancer patients at risk of febrile neutropenia in the era of COVID-19: a MASCC position paper
AbstractPatients with cancer are at higher risk of more severe COVID-19 infection and have more associated complications. The position paper describes the management of cancer patients, especially those receiving anticancer treatment, during the COVID-19 pandemic. Dyspnea is a common emergency presentation in patients with cancer with a wide range of differential diagnoses, including pulmonary embolism, pleural disease, lymphangitis, and infection, of which SARS-CoV-2 is now a pathogen to be considered. Screening interviews to determine whether patients may be infected with COVID-19 are imperative to prevent the spread of ...
Source: Supportive Care in Cancer - November 23, 2020 Category: Cancer & Oncology Source Type: research

Adverse childhood experiences (ACEs) and medically traumatic events (TEs) in adolescents and young adults (AYAs) with cancer: a report from the Promoting Resilience in Stress Management (PRISM) randomized controlled trial
AbstractObjectiveIn adolescents and young adults (AYAs) with cancer, we examined (1) the distribution and type of traumatic events (TEs) experienced prior to baseline assessment and (2) how a resilience intervention, Promoting Resilience in Stress Management (PRISM), impacted changes in patient-reported outcomes (PROs) for AYAs with and without TEs.MethodsAYAs (12 –25 years) within 1–10 weeks of diagnosis of new malignancy or ever diagnosed with advanced cancer were enrolled and randomly assigned to usual care (UC) with or without PRISM. To assess TEs, we screened medical records for traditionally defined adver...
Source: Supportive Care in Cancer - November 20, 2020 Category: Cancer & Oncology Source Type: research

Pseudoneutropenia as a factor-limiting access to chemotherapy for cancer patients: the effect of a simple meal
AbstractBackgroundAbsolute neutrophil count (ANC) below 1.5 g/l or 1 g/l is commonly used as a factor to determine the decision to administer antineoplastic treatment including chemotherapy and novel agents to cancer patients. This practice is based on observations that below this ANC, there is an increased risk of bacterial and fungal infection. This is further based on the assumption that this parameter always correctly reflects the true shortage of these germ-fighting cells in patients. In reality, the circulating pool of neutrophils is only one of four reservoirs (bone marrow, circulating, marginal and tissue pools) an...
Source: Supportive Care in Cancer - November 20, 2020 Category: Cancer & Oncology Source Type: research

Palliative care in onco-hematology: a perspective
This article also expresses the experience of an oncologic palliative care unit. More health education programs in PC are needed for specialized professionals in hematology, as well as a change of nowadays health politics, in order to increase the participation of this specialized care in hematology. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 20, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Comprehensive geriatric assessment and decision-making in older men with incurable but manageable (chronic) cancer
A Correction to this paper has been published:https://doi.org/10.1007/s00520-020-05893-0 (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 20, 2020 Category: Cancer & Oncology Source Type: research

Industry and MASCC —an opportunity not to be missed
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 19, 2020 Category: Cancer & Oncology Source Type: research

Returning to work in lung cancer survivors —a multi-center cross-sectional study in Germany
ConclusionsLung cancer survivors were found to be associated with a high risk of unemployment and very low professional reintegration after interruption due to illness. More comprehensive studies are needed to support lung cancer survivors and targeting of patients in need of special attention in rehabilitation that would benefit from the findings in the present study. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 19, 2020 Category: Cancer & Oncology Source Type: research

Physical activity, cardiorespiratory fitness, and cognitive function in postmenopausal women with breast cancer
AbstractPhysical activity may improve cognitive function in women with breast cancer. In a cross-sectional study, we explored the relationship between cognitive function and physical activity (actigraph) and cardiorespiratory fitness (sub-maximal graded exercise test) in 73 postmenopausal women with early stage breast cancer prior to the initiation of systemic adjuvant therapy. Cognitive function was assessed with a standardized battery of neurocognitive measures assessing eight domains. Data were analyzed using partial correlations, controlling for age and total hours of actigraph wear-time. Women were, on average, 63.71 ...
Source: Supportive Care in Cancer - November 19, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Salivary biomarkers in breast cancer: a cross-sectional study
Incorrect authornames. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Radiation dermatitis assessment tools used in breast cancer: A systematic review of measurement properties
ConclusionsCurrent standardized tools that measure CROs are subject to clinician interpretation and fail to represent the patient experience. Tools designed to assess PROs are promising in their assessments of the impact of RT on patient quality of life; however, most PRO tools are generic to all skin conditions and require further validation for use in breast cancer. Among tools that measure CROs, PROs, and BPs, there is insufficient evidence on their measurement properties to establish a “gold standard” for the assessment of RD in breast cancer patients. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 17, 2020 Category: Cancer & Oncology Source Type: research

Role of supportive care in improving the quality of life and reducing unscheduled hospital care in patients with metastatic breast cancer
ConclusionCSC can improve QoL in MBC. Painful patients might benefit more from CSC. UHC did not decrease for patients receiving CSC as expected possibly because of their important needs for clinical care. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 17, 2020 Category: Cancer & Oncology Source Type: research

Resilience: an essential element in head and neck cancer survivorship and quality of life
ConclusionsData suggest that resilience may buffer the influence of HNCa on QoL. Thus, screening for reduced levels of resilience may proactively facilitate identification of those who are most vulnerable to the psychosocial impact of HNCa. Interventions that foster resilience may ameliorate the challenges of HNCa and maximize QoL. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 17, 2020 Category: Cancer & Oncology Source Type: research

Quantitative-qualitative analyses of patient-reported pain response after palliative radiation therapy
ConclusionsAbout half of patients reported apPIP substantially disparate from theircPIP, and the change in pain measured by the 0 –10 scale tended to underestimate the degree of perceived pain improvement. Multiple themes were identified in qualitative analysis of pain response. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 16, 2020 Category: Cancer & Oncology Source Type: research

Time-dependent discrepancies between physician-assessed and patient-reported oxaliplatin-induced peripheral neuropathy in patients with metastatic colorectal cancer who received mFOLFOX6 plus bevacizumab: a post hoc analysis (WJOG4407GSS2)
This study investigated the relationship between physician-assessed and patient-reported oxaliplatin-induced peripheral neuropathy (OIPN) during treatment of metastatic colorectal cancer (mCRC) over time.MethodsA post hoc analysis was conducted for 191 patients with mCRC who received mFOLFOX6 plus bevacizumab in the WJOG4407G trial. Physician-assessed OIPN was graded by CTCAE every 2  weeks. Patient-reported OIPN was assessed with the FACT/GOG-Ntx (11 items, best score 44) at baseline and at 3, 6, and 9 months. Physician underestimation was defined as when the highest scores of the NTX1–4 sensory subscale/C...
Source: Supportive Care in Cancer - November 16, 2020 Category: Cancer & Oncology Source Type: research