Symptom burden among Northern Alberta radiotherapy patients with advanced cancer: mapping needs and gaps
ConclusionAlthough the symptom burden experienced by patients living with advanced cancer in rural and remote areas of Northern Alberta does not differ significantly from their urban counterparts, and community HCPs are knowledgeable regarding PC services, unmet needs within these communities remain. Continuing support for PC services in rural communities, as well as establishing care pathways for patients from rural populations traveling to urban centers to receive treatment, will help to minimize the unmet needs these patients experience. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Adherence to abiraterone or enzalutamide in elderly metastatic castration-resistant prostate cancer
ConclusionNon-adherence to abiraterone or enzalutamide for mCRPC may have an impact on disease response and be related to patients ’ frailty, suggesting their geriatric assessment and clinical interventions to monitor and increase their adherence. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Exercise is more effective than health education in reducing fatigue in fatigued cancer survivors
AbstractIntroductionCancer-related fatigue is a most debilitating side effect reported by survivors, often lasting years following treatment.PurposeTo determine the effects of a 10-week exercise intervention compared with a health education intervention on fatigue, quality of life outcomes and functional fitness in cancer survivors with documented fatigue.MethodsThis quasi-experimental study allocated 37 post-treatment fatigued cancer survivors (33 female, 30 breast cancer, aged 55  ± 2 years, time since treatment 2.3 ± 0.3 years; mean ± SEM) to an exercise group (...
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

A proposed tailored investigational algorithm for women treated for gynaecological cancer with long-term gastrointestinal consequences
This study reviewed gastrointestinal symptoms of women previously treated for gynaecological cancer and considered whether suggested algorithms could be amended to optimise management for this cohort.MethodsDemographic and clinical data recorded for patients attending a specialist consequences of cancer treatment gastroenterology service prospectively are reported using median and range. The Wilcoxon signed rank test analysed changes in symptoms between initial assessment to discharge from the service.ResultsBetween April 2013 and March 2016, 220 women, with a median age of 57  years (range 24–83 years), tr...
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

A systematic review of the impact of contemporary treatment modalities for cervical cancer on women ’s self-reported health-related quality of life
ConclusionWhereas most symptoms worsen during treatment and improve in the first 3  months after completing treatment, symptoms like lymphedema, menopausal symptoms, and sexual worries develop gradually and persist after curative treatment. These findings can be used to inform clinical practice and facilitate communication and shared decision-making. More research is needed in ve ry early cervical cancer and the impact of fertility sparing therapy on PROs. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Peripherally inserted central venous catheter (PICC) in outpatient and inpatient oncological treatment
AbstractPurposeSo far there is little evidence on peripherally inserted central venous catheter (PICC) in radiation oncology patients maintaining the access during the periods of ambulatory and hospital treatment.MethodsA total of 522 PICC placements in 484 patients were performed between 11/2011 and 07/2016 at the Department of Radiation Oncology and analysed retrospectively for complications and treatment- and patient-related factors during ambulatory and hospital inpatient use. On initial hospitalization, all patients received a multimodal radio-oncological treatment consisting of radiation and intravenous therapy admin...
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Moving forward on all fronts: impact, patterns, and barriers to exercise in cancer survivors and patients living with advanced disease
ConclusionsThere is an opportunity to improve exercise and related outcomes among a large percentage of both cancer survivors and patients living with advanced disease. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

The association between health-related quality of life and achievement of personalized symptom goal
AbstractPurposeThe aim of study was to explore the potential association between patient ’s self-reported physical symptom management goals as personalized symptom goal (PSGs) and health-related quality of life (HRQOL) in cancer patients. The secondary outcome was to investigate the relationship between number of physical symptoms not achieving the PSGs and HRQOL in cancer patients.MethodsThis single-center prospective observational study comprised 140 consecutive outpatients. We evaluated the PSGs and HRQOL using the Functional Assessment of Cancer Therapy –General (FACT-G). Patients were administered a self-r...
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

A nurse practitioner – led model of care improves access, early assessment and integration of oncology services: an evaluation study
ConclusionsThe implementation of the NP-led model of care has reduced ED presentations, optimised symptom management, and streamlined patient telephone enquiries using validated clinical assessment tools (Jones 2018) within cancer services. The telephone helpline was available for the broader local health district community and was actively utilised. Patient surveys were overwhelmingly positive. The model of care has improved symptom management for patients and reduced ED workload and presentation rates. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Exploring the role of oral microorganisms in the pathogenesis of mucositis by assessing their impact on metabolic activity and reproductive capacity of epithelial cells in vitro
ConclusionP. gingivalis,C. glabrata, andC. kefyr lowered the metabolic activity of oral epithelial cells in high concentrations, yet they did not influence the reproductive capacity of epithelial cells. Their impact on ulcerative oral mucositis is likely due to an effect on the migration, proliferation, and metabolism of epithelial cells. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Integration of patient-reported outcomes (PROs) for personalized symptom management in “real-world” oncology practices: a population-based cohort comparison study of impact on healthcare utilization
ConclusionFacilitating uptake of PROs data may impact healthcare utilization but requires examination in larger scale “real-world” trials. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Quality of life and its relation with nutritional status in patients with incurable cancer in palliative care
ConclusionOur findings support that impaired nutritional status was associated with poor QoL in incurable cancer patients. NR assessed by PG-SGA SF better reflects physical, emotional, symptom burden, and overall QoL scores. Thus, this tool may contribute in identifying patients at risk of deterioration QoL. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy
AbstractThis communication discusses the current challenges of oral mucositis (OM) management during the pandemic COVID-19 outbreak and reflects about an extraoral photobiomodulation protocol as an optimal alternative for preventing and treating OM in advanced cancer patients while minimizing the risk of infection by avoiding intraoral manipulation. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Patients ’ satisfaction with a supportive care program for young breast cancer patients in Mexico: Joven & amp; Fuerte supports patients ’ needs and eases their illness process
ConclusionsPatients ’ satisfaction with J&F is very high, reflecting that the program is meeting Mexican YWBC ’s needs by providing useful information means and support services in a limited-resource setting. Efforts must keep up to guarantee the program’s continuity and advocate for its extension to other oncologic centers. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Effects of curative-intent lung cancer therapy on functional exercise capacity and patient-reported outcomes
ConclusionsAmong the first prospective analysis of the effect of curative-intent lung cancer treatment on functional EC and PROs, we observed worsening dyspnea and fatigue, and possibly a decline in functional EC but not cancer-specific QoL at 1 to 3  months post-treatment. Interventions to reduce treatment-related morbidities and improve lung cancer survivorship may need to focus on reducing dyspnea, fatigue, and/or improving functional EC. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Guideline concordant care for prevention of acute chemotherapy-induced nausea and vomiting in children, adolescents, and young adults
AbstractPurposePrescribing guideline-recommended anti-emetics is an effective strategy to prevent CINV. However, the rate of guideline-concordant care is not well-understood. The purpose of this study was to describe the proportion of pediatric, adolescent, and young adult patients receiving HEC or MEC who received guideline-concordant antiemetic prophylaxis for acute CINV and to identify potential predictors of guideline-concordant antiemetic prophylaxis.MethodsUsing electronic health record data from 2016 through 2018, a retrospective single-institution cohort study was conducted to investigate how often patients less th...
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Comment to: Ryans K et al. Incidence and predictors of axillary web syndrome and its association with lymphedema in women following breast cancer treatment: a retrospective study
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Is intra-arterial hepatic chemotherapy painful?
ConclusionLengthening of the infusion time did not prevent the occurrence of abdominal pain significantly but was nonetheless decreased compared with patients undergoing short infusion durations. Pain was more common in patients who did not have a dose reduction and who presented with ulcer and extrahepatic perfusion. Abdominal pain occurred on average one cycle before ulcer or extrahepatic perfusion diagnosis. In current practice, pain should be an alarming indicator in patients receiving IAHC, as it may be associated with ulcer or extrahepatic perfusion and thus requiring opioids. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Correction to: A systematic review and meta-analysis of couple-based intervention on sexuality and the quality of life of cancer patients and their partners
Sentence incorrect. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Reply to: Effects of partly supervised and home-based exercise program in patients undergoing hematopoietic stem cell transplantation: a case-control study
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - August 26, 2020 Category: Cancer & Oncology Source Type: research

Understanding parents ’ communication experiences in childhood cancer: a qualitative exploration and model for future research
We examined parents’ health-ca re experiences during and after the child’s cancer treatment.MethodsWe recruited parents of children/adolescents (aged  
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Taxane-induced peripheral neuropathy: differences in patient report and objective assessment
ConclusionsDiscrepancies may exist between the patient experience of CIPN and objective assessments. Understanding these discrepancies may help to elucidate underlying mechanisms and better inform treatment strategies. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Advances and future directions in the use of mobile health in supportive cancer care: proceedings of the 2019 MASCC Annual Meeting symposium
ConclusionmHealth has the potential to revolutionize and transform cancer care delivery. Future research should guide further advances in the use of technology in supportive cancer care and carefully explore the safety, efficacy, cost-effectiveness, and implementation of interventions delivered through mHealth platforms. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Factors associated with return to work in breast cancer survivors treated at the Public Cancer Hospital in Brazil
ConclusionReturn to work was influenced by age, education level, previous activity types, axillary treatment, and physical sequelae related to loss of hand strength. Breast cancer treatment decreased the women ’s work capacity. Return to work improved the patients’ quality of life. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Emergency ambulatory outpatient management of immune-mediated hypophysitis
ConclusionCarefully selected emergency presentations with immune-mediated hypophysitis may be suitable for ambulatory management. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Precautions for yoga practice are necessary in cancer patients
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Uncertainty upon uncertainty: supportive Care for Cancer and COVID-19
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

A qualitative study about perspectives on implementing exercise-based rehabilitation in an acute cancer treatment setting: a good basis for further quantitative research
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Providing nutritional care to cancer patients during the COVID-19 pandemic: an Italian perspective
AbstractThe COVID-19 outbreak has drastically changed practices inside hospitals, which include oncology routines. In oncology, malnutrition was and certainly still is a frequent problem associated with an increase in treatment-related toxicity, a reduced response to cancer treatment, an impaired quality of life, and a worse overall prognosis. Even in this situation of healthcare crisis, nutritional support in cancer care is an essential element. During the current COVID-19 pandemic, there is a concrete high risk to see a dramatic worsening of cancer patients ’ nutritional status, who are left without adequate clinic...
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

The benefits of support groups for caregivers of patients with brain tumors
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Safe distance, safe patients! Therapeutic management of oncological patients affected by cutaneous and mucosal adverse events during the COVID-19 pandemic: an Italian experience
AbstractStringent measures have been taken to contain COVID-19 spread, limiting access only for urgent visits, surgery procedures, or hospitalizations and using teledermatology services for non-urgent cases. Management of oncological patients affected by chemo-, immune-, and radiotherapy-related cutaneous and mucosal adverse events is a challenge. Firstly because of the differential diagnosis of cutaneous rash (e.g., drug-related rash or paraviral exanthema). Secondly, oncological patients can suffer from xerosis, pruritus, and mucositis that contribute to cutaneous and mucosal barrier lesions, thus becoming vulnerable sit...
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Correction to: The quality of care of the dying in hospital —next-of-kin perspectives
The surname and name of Christoph (name) Ostgathe (surname) are reversed. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

The relationship between the positive aspects of caring and emotional distress among caregivers of patients with advanced oncological illness
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Preventing emergency department visits among patients with cancer: a scoping review
Table 2 is incorrect in the original manuscript. The correct table 2 is shown below (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Investigating relationships among cancer survivors ’ engagement in an online support community, social support perceptions, well-being, and moderating effects of existing (offline) social support
AbstractPurposeSocially supportive relationships help cancer survivors cope with their diagnosis and may improve quality of life; however, many survivors report unmet support and information needs. Online communities of survivors may address these needs, but research on their benefits have been equivocal. This cross-sectional, self-report study investigated relationships among cancer survivors ’ level of engagement in an online survivor community (The American Cancer Society Cancer Survivors Network®; CSN), perceptions of emotional/informational support available from online communities (“online social supp...
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Characteristics and outcomes of patients with solid tumors receiving chemotherapy in the intensive care unit
The objective of this study was to evaluate the short- and long-term outcomes of adult patients with solid tumors receiving chemotherapy in the intensive care unit (ICU).MethodsThis was a retrospective single-center study comparing the outcomes of patients with solid tumors who received chemotherapy in the ICU with a matched cohort of ICU patients (by age, sex, and tumor type) who did not receive chemotherapy. Conditional logistic regression and shared frailty Cox regression were used to assess short-term (ICU and hospital) mortality and death by 12-month post-hospital discharge, respectively.ResultsSeventy-three patients ...
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Motor ability, function, and health-related quality of life as correlates of symptom burden in patients with sclerotic chronic graft-versus-host disease receiving imatinib mesylate
ConclusionsFindings suggest the potential utility of administering patient-reported and performance-based functional measures, such as the DASH and the AMPS, to patients with cGVHD. By understanding the functional consequences of ScGVHD, interdisciplinary teams of health care providers, including rehabilitation professionals, can work to improve long-term outcomes. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Clinical and economic impact of medication reconciliation in cancer patients: a systematic review
ConclusionMedication reconciliation can reduce adverse drug events in cancer patients. More robust and economic evaluations are still required to support its development in everyday practice. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Development of a clinical prediction tool for cancer-associated venous thromboembolism (CAT): the MD Anderson Cancer Center CAT model
ConclusionOur model is effective and easy to incorporate in busy clinical settings and it does not depend on esoteric or difficult-to-obtain laboratory testing. Future external validation studies may provide further evidence for the applicability of our results. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Fertility counseling and sperm banking among adolescents and adults treated for cancer with curative intent in a developing country
AbstractPurposeIn developing countries, a higher percentage of patients develop cancer at a younger age. Cancer survival rates have significantly improved, highlighting the importance of survivorship programs that address late complications related to cancer itself or its treatment. The purpose of this study is to estimate the prevalence of fertility counseling and sperm banking and related factors among at-risk males newly diagnosed with cancer and planning to receive a potentially curative anticancer therapy.MethodsMedical records and hospital database of young male patients with newly diagnosed cancers and planned to st...
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Supportive care and unmet needs in patients with melanoma: a mixed-methods systematic review
ConclusionMelanoma-specific care and unmet care needs were identified most commonly in the informational domain, followed by psychological, social and physical domains. Oncology practitioners should consider enhancing their supportive care interventions throughout the journey of patient with melanoma to reduce or address their unmet needs. The results of this mixed-methods systematic review warrant further research using robust study designs, melanoma-specific validated outcome measures and complete reporting of data in terms of disease stage. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Nationwide prevalence of potential drug-drug interactions associated with non-anticancer agents in patients on oral anticancer agents in South Korea
ConclusionsThe risk of PDDIs in patients receiving OAAs increases, particularly with the concomitant use of PKIs with gastrointestinal or psychiatric drugs and endocrine agents with antidepressants. Considering the potential risk of chronic concomitant use of these drug classes in outpatients, healthcare professionals should be made aware of the potential interactions. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Cancer survivorship care during COVID-19 —perspectives and recommendations from the MASCC survivorship study group
(Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

The importance of and satisfaction with sex life among breast cancer survivors in comparison with healthy female controls and women with mental depression or arterial hypertension: results from the Finnish nationwide HeSSup cohort study
AbstractIntroductionBreast cancer (BC) and its treatment is associated with several physical and psychosocial changes that may influence sexuality for years after treatment. Women with BC show significantly greater rates of sexual dysfunction than do healthy women. The purpose of the study was to evaluate how a BC diagnosis associates with women ’s perceived sexuality and sexual satisfaction.Material and methodsThe data of the ongoing prospective Health and Social Support (HeSSup) survey was linked with national health registries. Respondents with registry data confirmed BC (n = 66), mental depression (...
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Optimizing cancer cure dialog: an analysis of pancreatic cancer patients ’ views regarding survival and cure
AbstractBackgroundPancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer. Clinicians commonly refer to surgical therapy as resection with curative intent. However, PDA cure rates after resection remain unknown and the definition of cure remains vague. We investigated how patients (the majority undergoing resection), family members, and clinicians understand the concept of cure, to better inform discussions with patients regarding PDA prognosis.MethodsIn a prospective survey, cohorts were asked to indicate the best definition of cure from three choices: 5-year survival endpoint (typically used in the literature), ...
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Cancer and end of life: the management provided during the year and the month preceding death in 2015 and causes of death in France
ConclusionsCancer management and death mostly occurred in SSH in France. Cancer patients frequently attend the emergency department and frequently receive chemotherapy during the last month of life. These data continue to contrast with those observed in Scandinavian- and English-speaking countries, in which management of the end of life at home is preferred. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of traditional Chinese Medicine combined with chemotherapy in patients with non-small cell lung cancer (NSCLC): a meta-analysis of randomized clinical trials
AbstractBackgroundThis meta-analysis systematically evaluated the efficacy of Traditional Chinese Medicine (TCM) combined with chemotherapy and provided evidence-based evidence for the treatment of non-small cell lung cancer.MethodsBiomedical databases including China National Knowledge Infrastructure (CNKI) database, Wanfang Database, PubMed, and Cochrane Library were searched from January 2005 to October 2019 for the clinical literature on Chinese medicine for treating non-small cell lung cancer. All randomized controlled trials (RCTs) concerning the TCM combined with chemotherapy for non-small cell lung cancer were sele...
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Cannabis use in pediatric cancer patients: what are they reading? A review of the online literature
ConclusionsHealth care providers should be aware that the overall quality of information found online is considered “satisfactory.” The majority of articles present a pro-cannabis opinion. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Food Purchasing Behavior of Food Insecure Cancer Patients Receiving Supplemental Food Vouchers
ConclusionsPatients who received a food voucher purchased more fruits and vegetables than national averages would suggest. They also spent less on sweetened beverages than national samples. Patients who were born outside of the United States or who were limited English proficient purchased significantly more healthy foods than English-speaking and American-born study patients. Supplemental food vouchers for food insecure cancer patients resulted in the purchase of healthy food items. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Perception of side effects associated with anticancer treatment in women with breast or ovarian cancer (KEM-GO-1): a prospective trial
ConclusionsSleep disturbances have lately emerged as the most severe problem in women with OC or BC receiving anticancer therapy. Concerns about family and partner were ranked second in the current study and first in previous investigations. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research