Cancers, Vol. 16, Pages 678: Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer

Conclusion: Our study revealed the HER2-E subtype conversion during LNM in BC. Macrophages were the crucial cell type in TME, inducing the downregulation of HR and upregulation of HER2, probably via MNX1. Targeting macrophages or MNX1 may provide new avenues for endocrine therapy and targeted treatment of BC patients with LNM.

Source: Cancers - February 5, 2024 Category: Cancer & Oncology Authors: Xiaoyan Zhang Fengyu Yang Zhijian Huang Xiaojun Liu Gan Xia Jieye Huang Yang Yang Junchen Li Jin Huang Yuxin Liu Ti Zhou Weiwei Qi Guoquan Gao Xia Yang Tags: Article Source Type: research