Pharmacogenetics of tamoxifen in breast cancer patients of African descent: Lack of data
Clin Transl Sci. 2024 Mar;17(3):e13761. doi: 10.1111/cts.13761.ABSTRACTTamoxifen, a selective estrogen receptor modulator, is used to treat hormone receptor-positive breast cancer. Tamoxifen acts as a prodrug, with its primary therapeutic effect mediated by its principal metabolite, endoxifen. However, tamoxifen has complex pharmacokinetics involving several drug-metabolizing enzymes and transporters influencing its disposition. Genes encoding enzymes involved in tamoxifen disposition exhibit genetic polymorphisms which vary widely across world populations. This review highlights the lack of data on tamoxifen pharmacogenet...
Source: Clinical Genitourinary Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Bianca Kruger Delva Shamley Nyarai Desiree Soko Collet Dandara Source Type: research
Erdheim ‑Chester disease of multisystem involvement with delayed diagnosis: A case report and literature review
Exp Ther Med. 2024 Feb 22;27(4):159. doi: 10.3892/etm.2024.12447. eCollection 2024 Apr.ABSTRACTErdheim-Chester disease (ECD) is a rare tumor of histiocytic origin, characterized by foamy or lipid-laden histiocytes mixed or surrounded by fibrosis that infiltrate multiple organs. Misdiagnosis is common due to the diversity of clinical presentations. The present study reported a case of ECD with the involvements of bone, cardiac, aorta and retroperitoneum. The patient had no obvious clinical symptoms and no noteworthy foamy histiocytes or Touton giant cells were found on pathological examination, delaying the diagnosis. The p...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiaotong Shi Guangzhi Sun Tongguan Li Mengjiao Xu Yixuan Liu Zhankui Wang Yanfeng Hou Source Type: research
Ovarian Suppression: Early Menopause and Late Effects
Opinion statementAround 90% of breast tumours are diagnosed in the early stage, with approximately 70% being hormone receptor-positive. The cornerstone of adjuvant therapy for early-stage hormone receptor-positive breast cancer is endocrine therapy, tailored according to disease stage, biological characteristics of the tumour, patient ’s comorbidities, preferences and age. In premenopausal patients with hormone receptor-positive breast cancer, ovarian function suppression is a key component of the adjuvant endocrine treatment in combination with an aromatase inhibitor or tamoxifen. Moreover, it can be used during chemoth...
Source: Current Treatment Options in Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research
The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral leukocytes
Brain Behav Immun. 2024 Mar 9:S0889-1591(24)00297-6. doi: 10.1016/j.bbi.2024.03.016. Online ahead of print.ABSTRACTGut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid receptor (FFAR)2, but intestinal epithelial cells (IEC) and peripheral myeloid cells do, we hypothesized that SCFA-mediated FFAR2 activation within the gut or peripheral leukocytes may impact microglia inflammation. To test this hypothesis, we developed a tamoxifen-inducible co...
Source: Brain, Behavior, and Immunity - March 11, 2024 Category: Neurology Authors: Maria Elisa Caetano-Silva Laurie Rund Mario Vailati-Riboni Stephanie Matt Katiria Soto-Diaz Jon Beever Jacob M Allen Jeffrey A Woods Andrew J Steelman Rodney W Johnson Source Type: research
The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral leukocytes
Brain Behav Immun. 2024 Mar 9:S0889-1591(24)00297-6. doi: 10.1016/j.bbi.2024.03.016. Online ahead of print.ABSTRACTGut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid receptor (FFAR)2, but intestinal epithelial cells (IEC) and peripheral myeloid cells do, we hypothesized that SCFA-mediated FFAR2 activation within the gut or peripheral leukocytes may impact microglia inflammation. To test this hypothesis, we developed a tamoxifen-inducible co...
Source: Brain, Behavior, and Immunity - March 11, 2024 Category: Neurology Authors: Maria Elisa Caetano-Silva Laurie Rund Mario Vailati-Riboni Stephanie Matt Katiria Soto-Diaz Jon Beever Jacob M Allen Jeffrey A Woods Andrew J Steelman Rodney W Johnson Source Type: research
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway
CONCLUSIONS: This study demonstrated that downregulation of MENA promoted tamoxifen resistance in the HR+ breast cancer tissues and cells by enhancing the AKT signaling pathway. Therefore, MENA is a promising prediction biomarker for determining tamoxifen sensitivity in patients with HR+ breast cancer.PMID:38459605 | DOI:10.1186/s13062-024-00464-3 (Source: Cancer Control)
Source: Cancer Control - March 8, 2024 Category: Cancer & Oncology Authors: Lifang He Chuanghong She Sen Jiang Zhaochang Qi Zihao Deng Likeng Ji Yukun Cui Jundong Wu Source Type: research
GSE248340 Hepatocyte CCAAT/enhancer-binding protein alpha restricts liver fibrosis by inhibiting secreted phosphoprotein 1 expression
This study demonstrates a novel hepatocyte CEBPA-SPP1 axis involved in modulating NASH fibrosis that supports hepatocyte CEBPA as an anti-NASH target. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE214615 Hepatocyte CCAAT/enhancer-binding protein alpha restricts liver fibrosis by inhibiting secreted phosphoprotein 1 expression (II)
This study demonstrates a novel hepatocyte CEBPA-SPP1 axis involved in modulating NASH fibrosis that supports hepatocyte CEBPA as an anti-NASH target. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE212646 Hepatocyte CCAAT/enhancer-binding protein alpha restricts liver fibrosis by inhibiting secreted phosphoprotein 1 expression (I)
This study demonstrates a novel hepatocyte CEBPA-SPP1 axis involved in modulating NASH fibrosis that supports hepatocyte CEBPA as an anti-NASH target. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway
Mammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in b... (Source: Biology Direct)
Source: Biology Direct - March 8, 2024 Category: Biology Authors: Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui and Jundong Wu Tags: Research Source Type: research
