Maternal oxidative stress during pregnancy and offspring neurodevelopment
Publication date: Available online 14 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Claudia Buss (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 15, 2021 Category: Neurology Source Type: research

ACSL4 Exacerbates Ischemic Stroke by Promoting Ferroptosis-induced Brain Injury and Neuroinflammation
Publication date: Available online 11 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Yu Cui, Yan Zhang, Xiaolong Zhao, Liming Shao, Guoping Liu, Chengjian Sun, Rui Xu, Zhaolong Zhang (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 12, 2021 Category: Neurology Source Type: research

Plasma-derived and recombinant C1 esterase inhibitor: binding profiles and neuroprotective properties in brain ischemia/reperfusion injury
Publication date: Available online 11 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Domenico Mercurio, Arianna Piotti, Alessia Valente, Marco Oggioni, Yolanda Ponstein, Edwin Van Amersfoort, Marco Gobbi, Stefano Fumagalli, Maria-Grazia De Simoni (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 12, 2021 Category: Neurology Source Type: research

Mentorship Memoriam: Mark Laudenslager, PhD
Publication date: Available online 11 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Monika Fleshner (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 12, 2021 Category: Neurology Source Type: research

Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice
Publication date: Available online 12 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): L. Gouweleeuw, H. Wajant, O. Maier, U.L.M. Eisel, W.M. Blankesteijn, R.G. Schoemaker (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 12, 2021 Category: Neurology Source Type: research

Mentorship Memoriam: Mark Laudenslager, PhD.
PMID: 33444730 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 11, 2021 Category: Neurology Authors: Fleshner M Tags: Brain Behav Immun Source Type: research

Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice.
CONCLUSION: Early receptor interventions, but not non-specific TNF inhibition, increased mortality. Apart from this undesired effect, the general beneficial profile after TNFR2 stimulation, rather than the unfavourable effects of TNFR1 inhibition, would render TNFR2 stimulation preferable over non-specific TNF inhibition in MI with comorbid depression. However, follow-up studies regarding optimal timing and dosing are needed. PMID: 33444731 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 11, 2021 Category: Neurology Authors: Gouweleeuw L, Wajant H, Maier O, Eisel ULM, Blankesteijn WM, Schoemaker RG Tags: Brain Behav Immun Source Type: research

Plasma-derived and recombinant C1 esterase inhibitor: binding profiles and neuroprotective properties in brain ischemia/reperfusion injury.
In conclusion, we show that rhC1INH exhibits stronger neuroprotective effects than the corresponding plasma-derived protein after experimental ischemia/reperfusion injury in the brain, placing it as a promising drug for stroke. Differential effects are likely related to more effective MBL inhibition which further confirms it as a useful pharmacological target for stroke. PMID: 33444732 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 11, 2021 Category: Neurology Authors: Mercurio D, Piotti A, Valente A, Oggioni M, Ponstein Y, Van Amersfoort E, Gobbi M, Fumagalli S, De Simoni MG Tags: Brain Behav Immun Source Type: research

ACSL4 Exacerbates Ischemic Stroke by Promoting Ferroptosis-induced Brain Injury and Neuroinflammation.
Abstract s Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role of ACSL4 in the progression of ischemic stroke is unclear. Here, we found that ACSL4 expression was suppressed in the early phase of ischemic stroke and this suppression was induced by HIF-1α. Knockdown of ACSL4 protected mice against brain ischemia, whereas, forced overexpression of ACSL4 exacerbated ischemic brain injury. ACSL4 promoted neuronal death via enhancing lipid peroxidation, a marker of ferroptosis. Moreover, k...
Source: Brain, Behavior, and Immunity - January 11, 2021 Category: Neurology Authors: Cui Y, Zhang Y, Zhao X, Shao L, Liu G, Sun C, Xu R, Zhang Z Tags: Brain Behav Immun Source Type: research

Special Issue: The intersection of inflammation and metabolism in neuropsychiatric disorders
Publication date: Available online 27 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jennifer C. Felger, Lucile Capuron (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 10, 2021 Category: Neurology Source Type: research

Maternal Autoimmunity and Inflammation are Associated with Childhood Tics and Obsessive-Compulsive Disorder: Transcriptomic Data show Common Enriched Innate Immune Pathways
Publication date: Available online 8 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Hannah F. Jones, Velda X. Han, Shrujna Patel, Brian S. Gloss, Nicolette Soler, Alvin Ho, Suvasini Sharma, Kavitha Kothur, Margherita Nosadini, Louise Wienholt, Chris Hardwick, Elizabeth H. Barnes, Jacqueline R. Lim, Sarah Alshammery, Timothy C. Nielsen, Melanie Wong, Markus J. Hofer, Natasha Nassar, Wendy Gold, Fabienne Brilot (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 10, 2021 Category: Neurology Source Type: research

Stress impairs response to antidepressants via HPA axis and immune system activation
Publication date: Available online 8 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Andreas Menke, Felix Nitschke, Anna Hellmuth, Jacqueline Helmel, Catherina Wurst, Saskia Stonawski, Manuel Blickle, Carolin Weiß, Heike Weber, Leif Hommers, Katharina Domschke, Jürgen Deckert (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 10, 2021 Category: Neurology Source Type: research

Targeting Peroxisome Proliferator-Activated Receptor-α (PPAR- α) to Reduce Paclitaxel-Induced Peripheral Neuropathy
Publication date: Available online 9 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Martial Caillaud, Nipa H. Patel, Alyssa White, Mackinsey Wood, Katherine M. Contreras, Wisam Toma, Yasmin Alkhlaif, Jane L. Roberts, Tammy H. Tran, Asti B. Jackson, Justin Poklis, David A. Gewirtz, M. Imad Damaj (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 10, 2021 Category: Neurology Source Type: research

The severity of the pathogen-induced acute sickness response is affected by polymorphisms in genes of the NLRP3 inflammasome pathway
Publication date: Available online 9 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Braulio M. Valencia, Erin Cvejic, Ute Vollmer-Conna, Ian B. Hickie, Denis Wakefield, Hui Li, Vincent Pedergnana, Chaturaka Rodrigo, Andrew R. Lloyd (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 10, 2021 Category: Neurology Source Type: research

Targeting Peroxisome Proliferator-Activated Receptor- α (PPAR- α) to Reduce Paclitaxel-Induced Peripheral Neuropathy.
CONCLUSIONS AND IMPLICATIONS: Taken together, our results show for the first time the therapeutic potential (prevention and reversal) of fibrates in PIPN and opens to a potential pharmacological repurposing of these drugs. PMID: 33434562 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 9, 2021 Category: Neurology Authors: Caillaud M, Patel NH, White A, Wood M, Contreras KM, Toma W, Alkhlaif Y, Roberts JL, Tran TH, Jackson AB, Poklis J, Gewirtz DA, Imad Damaj M Tags: Brain Behav Immun Source Type: research

The severity of the pathogen-induced acute sickness response is affected by polymorphisms in genes of the NLRP3 inflammasome pathway.
Abstract The acute sickness response (ASR) is a stereotyped set of symptoms including fatigue, pain, and disturbed mood, which are present in most acute infections. The immunological mechanisms of the ASR are conserved, with variations in severity determined partly by the pathogen, but also by polymorphisms in host genes. ASR was characterised in three different serologically-confirmed acute infections in Caucasians (n=484) across four symptom domains or endophenotypes (termed 'Fatigue', 'Musculoskeletal pain', 'Mood disturbance', and 'Acute sickness'). Correlations were sought with functional single nucleotide po...
Source: Brain, Behavior, and Immunity - January 9, 2021 Category: Neurology Authors: Valencia BM, Cvejic E, Vollmer-Conna U, Hickie IB, Wakefield D, Li H, Pedergnana V, Rodrigo C, Lloyd AR Tags: Brain Behav Immun Source Type: research

A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes
Publication date: Available online 8 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Yaoyu Pu, Yunfei Tan, Youge Qu, Lijia Chang, Siming Wang, Yan Wei, Xingming Wang, Kenji Hashimoto (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 8, 2021 Category: Neurology Source Type: research

Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP
Publication date: Available online 8 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Sathyanarayanan Rajagopal, Changjun Yang, Kelly M. DeMars, Ranjana Poddar, Eduardo Candelario-Jalil, Surojit Paul (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 8, 2021 Category: Neurology Source Type: research

Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain
Publication date: Available online 7 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Andrew J. Kwilasz, Suzanne M. Green Fulgham, Julissa Chante Duran-Malle, Anouk E.W. Schrama, Eric H. Mitten, Laurel S. Todd, Hardik P. Patel, Tracey A. Larson, Madison A. Clements, Kevin M. Harris, Scott T. Litwiler, Lewis O. Harvey, Steven F. Maier, Raymond A. Chavez, Kenner C. Rice, Anne-Marie Van Dam, Linda R. Watkins (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 7, 2021 Category: Neurology Source Type: research

Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
Abstract The neuron-specific tyrosine phosphatase STEP is emerging as a key neuroprotectant against acute ischemic stroke. However, it remains unclear how STEP impacts the outcome of stroke. We find that the exacerbation of ischemic brain injury in STEP deficient mice involves an early onset and sustained activation of neuronal p38 mitogen activated protein kinase, a substrate of STEP. This leads to rapid increase in the expression of neuronal cyclooxygenase-2 and synthesis of prostaglandin E2, causing change in microglial morphology to an amoeboid activated state, activation of matrix metalloproteinase-9, cleavag...
Source: Brain, Behavior, and Immunity - January 7, 2021 Category: Neurology Authors: Rajagopal S, Yang C, DeMars KM, Poddar R, Candelario-Jalil E, Paul S Tags: Brain Behav Immun Source Type: research

Maternal Autoimmunity and Inflammation are Associated with Childhood Tics and Obsessive-Compulsive Disorder: Transcriptomic Data show Common Enriched Innate Immune Pathways.
Abstract Although genetic variation is a major risk factor of neurodevelopmental disorders, environmental factors during pregnancy and early life are also important in disease expression. Animal models demonstrate that maternal inflammation causes fetal neuroinflammation and neurodevelopmental deficits, and brain transcriptomics of neurodevelopmental disorders in humans show upregulated differentially expressed genes are enriched in immune pathways. We prospectively recruited 200 sequentially referred children with tic disorders/obsessive-compulsive disorder (OCD), 100 autoimmune neurological controls, and 100 age...
Source: Brain, Behavior, and Immunity - January 7, 2021 Category: Neurology Authors: Jones HF, Han VX, Patel S, Gloss BS, Soler N, Ho A, Sharma S, Kothur K, Nosadini M, Wienholt L, Hardwick C, Barnes EH, Lim JR, Alshammery S, Nielsen TC, Wong M, Hofer MJ, Nassar N, Gold W, Brilot F, Mohammad SS, Dale RC Tags: Brain Behav Immun Source Type: research

Stress impairs response to antidepressants via HPA axis and immune system activation.
This study aims to disentangle this interaction by investigating the effects on two of the main stress-response systems of the body, the hypothalamic-pituitary-adrenal (HPA-) axis and the immune system in depressed patients. The function of the HPA-axis was assessed by measuring FKBP5, SGK1 and NR3C1 mRNA-expression in peripheral blood after an in vivo glucocorticoid receptor (GR) challenge with 1.5mg dexamethasone in 150 depressed in-patients (47.4% females). Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ), severe life events occurring one year prior to hospital admission were assessed with t...
Source: Brain, Behavior, and Immunity - January 7, 2021 Category: Neurology Authors: Menke A, Nitschke F, Hellmuth A, Helmel J, Wurst C, Stonawski S, Blickle M, Weiß C, Weber H, Hommers L, Domschke K, Deckert J Tags: Brain Behav Immun Source Type: research

A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.
In this study, we investigated whether fecal microbiota transplantation (FMT) from Chrna7 KO mice causes depression-like phenotypes in mice treated with an antibiotic cocktail (ABX). Chrna7 KO mice with depression-like phenotypes show an abnormal gut microbiota composition, although the alpha diversity and beta diversity were not altered. FMT from Chrna7 KO mice caused depression-like phenotypes, systemic inflammation, and downregulation of synaptic proteins in the prefrontal cortex (PFC) in the ABX-treated mice compared to FMT from the control mice. The boxplots representing the FMT group from the KO mice were distanced f...
Source: Brain, Behavior, and Immunity - January 7, 2021 Category: Neurology Authors: Pu Y, Tan Y, Qu Y, Chang L, Wang S, Wei Y, Wang X, Hashimoto K Tags: Brain Behav Immun Source Type: research

Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
Publication date: Available online 4 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Susan M. Burks, Hector Rosas-Hernandez, Manuel Alenjandro Ramirez-Lee, Elvis Cuevas, John C. Talpos (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 5, 2021 Category: Neurology Source Type: research

Adapted sickness behavior – why it is not enough to limit the COVID-19 spread?
Publication date: Available online 4 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Jaouad Bouayed, Torsten Bohn (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 5, 2021 Category: Neurology Source Type: research

Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models
Publication date: Available online 4 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Xulai Shi, Kaiyu Guan, Xuyan Peng, Bingru Xu, Xianyong Zhou, Shao Wang, Shengnan Xu, Miaomiao Zheng, Jing Huang, Xiaoyang Wan, Wanchun Guan, Kuan-Pin Su, Minjie Ye, Xiang Gao, Zhan Yin, Xi Li (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 5, 2021 Category: Neurology Source Type: research

Altered Circadian Rhythms in a Mouse Model of Neurodevelopmental Disorders Based on Prenatal Maternal Immune Activation
Publication date: Available online 5 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Tara C. Delorme, Lalit K. Srivastava, Nicolas Cermakian (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 5, 2021 Category: Neurology Source Type: research

Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
Publication date: Available online 2 January 2021Source: Brain, Behavior, and ImmunityAuthor(s): Jonas Leinweber, Daniella M. Mizurini, Ivo M.B. Francischetti, Michael Fleischer, Dirk M. Hermann, Christoph Kleinschnitz, Friederike Langhauser (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 4, 2021 Category: Neurology Source Type: research

Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models.
This study aimed to systematically investigate the genomic and pharmacological manipulations of ghrelin functioning in ADHD-like symptoms in zebrafish models and validated the effects of ghrelin polymorphisms in human subjects with ADHD. We firstly generated ghrelinΔ/Δ zebrafish mutant, which displayed hyperactive, attention deficit-like and impulsive-like behaviors, as well as endophenotypes, mimicking human ADHD. GhrelinΔ/Δ zebrafish exhibited downregulated expression levels of wnt1, wnt3a, wnt5a that are critical for dopaminergic neuron development to possibly regulate their number and spatial or...
Source: Brain, Behavior, and Immunity - January 4, 2021 Category: Neurology Authors: Shi X, Guan K, Peng X, Xu B, Zhou X, Wang S, Xu S, Zheng M, Huang J, Wan X, Guan W, Su KP, Ye M, Gao X, Yin Z, Li X Tags: Brain Behav Immun Source Type: research

Altered Circadian Rhythms in a Mouse Model of Neurodevelopmental Disorders Based on Prenatal Maternal Immune Activation.
Abstract Individuals with neurodevelopmental disorders, such as schizophrenia and autism spectrum disorder, exhibit various sleep and circadian rhythm disturbances that often persist and worsen throughout the lifespan. To study the interaction between circadian rhythm disruption and neurodevelopmental disorders, we utilized a mouse model based on prenatal maternal immune activation (MIA). We hypothesized that MIA exposure would lead to impaired circadian locomotor activity rhythms in adult mouse offspring. We induced MIA by injecting pregnant dams with polyinosinic:polycytidylic acid (poly IC) at embryonic day 9.5...
Source: Brain, Behavior, and Immunity - January 4, 2021 Category: Neurology Authors: Delorme TC, Srivastava LK, Cermakian N Tags: Brain Behav Immun Source Type: research

Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China in December 2019. On February 11, the World Health Organization (WHO) announced the name for the new illness caused by SARS-CoV-2: COVID-19. By March 11, the outbreak of COVID-19 was declared a pandemic by the WHO. This virus has extensively altered daily life for many across the globe, while claiming hundreds of thousands of lives. While fundamentally a respiratory illness, many infected individuals experience symptoms that involve the central nervous system (CNS). It is likely that many of these symptoms are the result ...
Source: Brain, Behavior, and Immunity - January 4, 2021 Category: Neurology Authors: Burks SM, Rosas-Hernandez H, Alenjandro Ramirez-Lee M, Cuevas E, Talpos JC Tags: Brain Behav Immun Source Type: research

Adapted sickness behavior - why it is not enough to limit the COVID-19 spread?
PMID: 33412256 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 4, 2021 Category: Neurology Authors: Bouayed J, Bohn T Tags: Brain Behav Immun Source Type: research

Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
This study shows for the first time a protective effect of agaphelin characterized by smaller infarct volume, reduced neurological deficits and reduced animal mortality. This protective effect was associated with reduced local thrombus formation, increased blood-brain barrier integrity and reduced brain inflammatory response. It is essential to mention that the protective effect of agaphelin was not linked to an increased risk of intracerebral bleeding. The promotion of brain tissue survival and inhibition of thromboinflammation identifies agaphelin as a promising treatment option in ischemic stroke, which considering the ...
Source: Brain, Behavior, and Immunity - January 2, 2021 Category: Neurology Authors: Leinweber J, Mizurini DM, Francischetti IMB, Fleischer M, Hermann DM, Kleinschnitz C, Langhauser F Tags: Brain Behav Immun Source Type: research

Platelet Endothelial Cell Adhesion Molecule-1 is a Gatekeeper of Neutrophil Transendothelial Migration in Ischemic Stroke
Publication date: Available online 31 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jack Winneberger, Sebastian Schöls, Katrin Lessmann, Javier Rández-Garbayo, Alexander T. Bauer, Ayan M. Yusuf, Dirk M. Herman, Matthias Gunzer, Stefan W. Schneider, Jens Fiehler, Christian Gerloff, Mathias Gelderblom, Peter Ludewig, Tim Magnus (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 1, 2021 Category: Neurology Source Type: research

Reply to letter
Publication date: Available online 24 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Wilson Tam, Roger Ho, Cyrus Ho, Fengyi Hao, Wanqiu Tan, Roger Ho (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 31, 2020 Category: Neurology Source Type: research

A systematic, integrative review of the effects of the endocannabinoid system on inflammation and neurogenesis in animal models of affective disorders
Publication date: Available online 28 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Juliette Giacobbe, Alessia Marrocu, Maria Grazia Di Benedetto, Carmine M. Pariante, Alessandra Borsini (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 29, 2020 Category: Neurology Source Type: research

Social Psychoneuroimmunology: Understanding Bidirectional Links Between Social Experiences and the Immune System
Publication date: Available online 28 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Keely A. Muscatell (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 29, 2020 Category: Neurology Source Type: research

Editorial: The Intersection of Inflammation and Metabolism in Neuropsychiatric Disorders
Publication date: Available online 27 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jennifer C. Felger, Lucile Capuron (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 28, 2020 Category: Neurology Source Type: research

High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms
Publication date: Available online 24 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Christiana Franke, Caroline Ferse, Jakob Kreye, S. Momsen Reincke, Elisa Sanchez-Sendin, Andrea Rocco, Mirja Steinbrenner, Stefan Angermair, Sascha Treskatsch, Daniel Zickler, Kai-Uwe Eckardt, Rick Dersch, Jonas Hosp, Heinrich J. Audebert, Matthias Endres, J. Christoph Ploner, Harald Prüss (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 25, 2020 Category: Neurology Source Type: research

Sex-specific associations between cerebrospinal fluid inflammatory marker levels and cognitive function in antiretroviral treated people living with HIV in rural Uganda
Publication date: Available online 24 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Alyssa C. Vecchio, Dionna W. Williams, Yanxun Xu, Danyang Yu, Deanna Saylor, Sarah Lofgren, Riley O'Toole, David R. Boulware, Noeline Nakasujja, Gertrude Nakigozi, Alice Kisakye, James Batte, Richard Mayanja, Aggrey Anok, Steven J. Reynolds, Thomas C. Quinn, Ronald H. Gray, Maria J. Wawer, Ned Sacktor, Leah H. Rubin (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 25, 2020 Category: Neurology Source Type: research

Voluntary exercise ameliorates synaptic pruning deficits in sleep-deprived adolescent mice
Publication date: Available online 24 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Li-Heng Tuan, Chih-Yu Tsao, Lukas Jyuhn-Hsiarn Lee, Li-Jen Lee (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 25, 2020 Category: Neurology Source Type: research

Dear Editor This is a reply letter to Cruz and colleagues. Sincerely Roger
Publication date: Available online 24 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 25, 2020 Category: Neurology Source Type: research

Letter to editor about the article “Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry” (Hao et al., 2020)
Publication date: Available online 25 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Lidiane Da Cruz Morais, Ana Karolina Marques Moriel Tavares (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 25, 2020 Category: Neurology Source Type: research

How handling extreme C-reactive protein (CRP) values and regularization influences CRP and depression criteria associations in network analyses.
Abstract Increasingly, it has been recognized that analysis at the symptom, rather than diagnostic, level will drive progress in the field of immunopsychiatry. Network analysis offers a useful tool in this pursuit with the ability to identify associations between immune markers and individual symptoms, independent of all other variables modeled. However, investigation into how methodological decisions (i.e., including vs. excluding participants with C-reactive protein (CRP)>10 mg/L, regularized vs. nonregularized networks) influence results is necessary to establish best practices for the use of network an...
Source: Brain, Behavior, and Immunity - December 23, 2020 Category: Neurology Authors: Moriarity DP, Horn SR, Kautz MM, Haslbeck JMB, Alloy LB Tags: Brain Behav Immun Source Type: research

Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia–ischemia
Publication date: Available online 14 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Kerstin Mülling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Köster, Dirk Hermann, Matthias Gunzer, Ursula Felderhoff-Müser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 23, 2020 Category: Neurology Source Type: research

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: integrating the phenotypic, molecular and neuroanatomical dimensions
Publication date: Available online 23 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Zümrüt Duygu Sen, Lena Vera Danyeli, Marie Woelfer, Femke Lamers, Gerd Wagner, Thomas Sobanski, Martin Walter (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 23, 2020 Category: Neurology Source Type: research

Linking the hemodynamic consequences of adverse childhood experiences to an altered HPA axis and acute stress response
Publication date: Available online 21 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Kylie S. Dempster, Deborah D. O'Leary, Adam J. MacNeil, Gary J. Hodges, Terrance J. Wade (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 22, 2020 Category: Neurology Source Type: research

Repeated allergic asthma in early versus late pregnancy differentially impacts offspring brain and behavior development
Publication date: Available online 21 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jamie S. Church, Juan M. Tamayo, Paul Ashwood, Jared J. Schwartzer (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 22, 2020 Category: Neurology Source Type: research

Inducing inflammation following subacute spinal cord injury in female rats: a double-edged sword to promote motor recovery
Publication date: Available online 21 December 2020Source: Brain, Behavior, and ImmunityAuthor(s): Emma Schmidt, Pamela Raposo, Romana Vavrek, Karim Fouad (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 22, 2020 Category: Neurology Source Type: research

Editorial Board
Publication date: January 2021Source: Brain, Behavior, and Immunity, Volume 91Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 16, 2020 Category: Neurology Source Type: research