Exercise and Adrenergic Regulation of Immunity
Brain Behav Immun. 2021 Jul 21:S0889-1591(21)00274-9. doi: 10.1016/j.bbi.2021.07.010. Online ahead of print.ABSTRACTExercise training has a profound impact on immunity, exerting a multitude of positive effects in indications such as immunosenescence, cancer, viral infections and inflammatory diseases. The immune, endocrine and central nervous systems work in a highly synergistic manner and it has become apparent that catecholamine signaling through leukocyte β-adrenergic receptors (β-ARs) is a key mechanism by which exercise mediates improvements in immune function to help mitigate numerous disease conditions. Ce...
Source: Brain, Behavior, and Immunity - July 24, 2021 Category: Neurology Authors: Richard J Simpson Tim K Bo ßlau Christopher Weyh Grace M Niemiro Helena Batatinha Kyle A Smith Karsten Kr üger Source Type: research

Exercise and Adrenergic Regulation of Immunity
Brain Behav Immun. 2021 Jul 21:S0889-1591(21)00274-9. doi: 10.1016/j.bbi.2021.07.010. Online ahead of print.ABSTRACTExercise training has a profound impact on immunity, exerting a multitude of positive effects in indications such as immunosenescence, cancer, viral infections and inflammatory diseases. The immune, endocrine and central nervous systems work in a highly synergistic manner and it has become apparent that catecholamine signaling through leukocyte β-adrenergic receptors (β-ARs) is a key mechanism by which exercise mediates improvements in immune function to help mitigate numerous disease conditions. Ce...
Source: Brain, Behavior, and Immunity - July 24, 2021 Category: Neurology Authors: Richard J Simpson Tim K Bo ßlau Christopher Weyh Grace M Niemiro Helena Batatinha Kyle A Smith Karsten Kr üger Source Type: research

Exercise and Adrenergic Regulation of Immunity
Brain Behav Immun. 2021 Jul 21:S0889-1591(21)00274-9. doi: 10.1016/j.bbi.2021.07.010. Online ahead of print.ABSTRACTExercise training has a profound impact on immunity, exerting a multitude of positive effects in indications such as immunosenescence, cancer, viral infections and inflammatory diseases. The immune, endocrine and central nervous systems work in a highly synergistic manner and it has become apparent that catecholamine signaling through leukocyte β-adrenergic receptors (β-ARs) is a key mechanism by which exercise mediates improvements in immune function to help mitigate numerous disease conditions. Ce...
Source: Brain, Behavior, and Immunity - July 24, 2021 Category: Neurology Authors: Richard J Simpson Tim K Bo ßlau Christopher Weyh Grace M Niemiro Helena Batatinha Kyle A Smith Karsten Kr üger Source Type: research

Defining the absolute risk of maternal infections on offspring neurodevelopmental outcomes: how to ensure your model is not lost in translation
Brain Behav Immun. 2021 Jul 20:S0889-1591(21)00272-5. doi: 10.1016/j.bbi.2021.07.008. Online ahead of print.NO ABSTRACTPMID:34298095 | DOI:10.1016/j.bbi.2021.07.008 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 23, 2021 Category: Neurology Authors: Rachel A Hill Source Type: research

An Immunogenomic Phenotype Predicting Behavioral Treatment Response: Toward Precision Psychiatry for Mothers and Children with Trauma Exposure
Brain Behav Immun. 2021 Jul 20:S0889-1591(21)00276-2. doi: 10.1016/j.bbi.2021.07.012. Online ahead of print.ABSTRACTInflammatory pathways predict antidepressant treatment non-response among individuals with major depression; yet, this phenomenon may have broader transdiagnostic and transtherapeutic relevance. Among trauma-exposed mothers (Mage=32 years) and their young children (M=4 years), we tested whether genomic and proteomic biomarkers of pro-inflammatory imbalance prospectively predicted treatment response (PTSD and depression) to an empirically-supported behavioral treatment. Forty-three mother-child dyads without c...
Source: Brain, Behavior, and Immunity - July 23, 2021 Category: Neurology Authors: Kirstin Aschbacher Steve Cole Melissa Hagan Luisa Rivera Alyssa Baccarella Owen M Wolkowitz Alicia Lieberman Nicole R Bush Source Type: research

Systemic inflammation and neuronal hyperexcitability: Deciphering cellular neuropathology of sickness behaviour
Brain Behav Immun. 2021 Jul 20:S0889-1591(21)00277-4. doi: 10.1016/j.bbi.2021.07.013. Online ahead of print.NO ABSTRACTPMID:34298097 | DOI:10.1016/j.bbi.2021.07.013 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 23, 2021 Category: Neurology Authors: Si-Si Lin Alexei Verkhratsky Source Type: research

Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury
This study highlights the importance of studying geriatric models of SCI, and that inflammatory mediators such as miR-155 are promising targets after SCI for improving pain relief and longevity.PMID:34284114 | DOI:10.1016/j.bbi.2021.07.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 20, 2021 Category: Neurology Authors: Andrew D Gaudet Laura K Fonken Monica T Ayala Steven F Maier Linda R Watkins Source Type: research

Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury
This study highlights the importance of studying geriatric models of SCI, and that inflammatory mediators such as miR-155 are promising targets after SCI for improving pain relief and longevity.PMID:34284114 | DOI:10.1016/j.bbi.2021.07.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 20, 2021 Category: Neurology Authors: Andrew D Gaudet Laura K Fonken Monica T Ayala Steven F Maier Linda R Watkins Source Type: research

Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury
This study highlights the importance of studying geriatric models of SCI, and that inflammatory mediators such as miR-155 are promising targets after SCI for improving pain relief and longevity.PMID:34284114 | DOI:10.1016/j.bbi.2021.07.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 20, 2021 Category: Neurology Authors: Andrew D Gaudet Laura K Fonken Monica T Ayala Steven F Maier Linda R Watkins Source Type: research

Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury
This study highlights the importance of studying geriatric models of SCI, and that inflammatory mediators such as miR-155 are promising targets after SCI for improving pain relief and longevity.PMID:34284114 | DOI:10.1016/j.bbi.2021.07.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 20, 2021 Category: Neurology Authors: Andrew D Gaudet Laura K Fonken Monica T Ayala Steven F Maier Linda R Watkins Source Type: research

Associations of Immunological Proteins/Traits with Schizophrenia, Major Depression and Bipolar Disorder: A Bi-Directional Two-Sample Mendelian Randomization Study
CONCLUSIONS: We report evidence in support of potential causal associations of several immunological proteins/traits with schizophrenia, and of IL-6 with depression. Some of the findings did not survive correction for multiple testing and so replication in larger samples is required. Experimental studies are also required to further examine causality, mechanisms, and treatment potential for these immunological proteins/pathways for schizophrenia and depression.PMID:34280516 | DOI:10.1016/j.bbi.2021.07.009 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 19, 2021 Category: Neurology Authors: Benjamin I Perry Rachel Upthegrove Nils Kappelmann Peter B Jones Stephen Burgess Golam M Khandaker Source Type: research

The urgent need for more basic research on SARS-Cov2 infection and vaccines in assessing potential psychoneurological effects using maternal immune activation (MIA) and other preclinical modeling
Publication date: Available online 1 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): William J. Murphy (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 13, 2021 Category: Neurology Source Type: research

The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation
We examined the association of TRYCATs levels with 1) the presence of Major Depressive Disorder (MDD), 2) depressive symptom profiles and 3) inflammatory markers.METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n = 1100) or remitted (n = 753) MDD DSM-IV diagnosis and healthy controls (n = 642). Plasma levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KynA), quinolinic acid (QA), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) were measured. Atypical/energy-related symptom (AES), melancholic symptom (MS) and anxious-distre...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Yuri Milaneschi Kelly A Allers Aartjan T F Beekman Erik J Giltay Sascha Keller Robert A Schoevers Sigurd D S üssmuth Heiko G Niessen Brenda W J H Penninx Source Type: research

Kefir ameliorates specific microbiota-gut-brain axis impairments in a mouse model relevant to autism spectrum disorder
Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00268-3. doi: 10.1016/j.bbi.2021.07.004. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There is a great need for more effective strategies to improve quality of life in ASD subjects. The gut microbiome has emerged as a potential therapeutic target in ASD. A novel modulator of the gut microbiome, the traditionally fermented milk drink kefir, has recently been shown to modulate the microbiota and decrease repetitive behaviour, one of the hallmarks of ASD, in mice. As ...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Marcel van de Wouw Calum J Walsh Giulia M D Vigano Joshua M Lyte Marcus Boehme Andreu Gual-Grau Fiona Crispie Aaron M Walsh Gerard Clarke Timothy G Dinan Paul D Cotter John F Cryan Source Type: research

The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation
We examined the association of TRYCATs levels with 1) the presence of Major Depressive Disorder (MDD), 2) depressive symptom profiles and 3) inflammatory markers.METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n = 1100) or remitted (n = 753) MDD DSM-IV diagnosis and healthy controls (n = 642). Plasma levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KynA), quinolinic acid (QA), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) were measured. Atypical/energy-related symptom (AES), melancholic symptom (MS) and anxious-distre...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Yuri Milaneschi Kelly A Allers Aartjan T F Beekman Erik J Giltay Sascha Keller Robert A Schoevers Sigurd D S üssmuth Heiko G Niessen Brenda W J H Penninx Source Type: research

Kefir ameliorates specific microbiota-gut-brain axis impairments in a mouse model relevant to autism spectrum disorder
Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00268-3. doi: 10.1016/j.bbi.2021.07.004. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There is a great need for more effective strategies to improve quality of life in ASD subjects. The gut microbiome has emerged as a potential therapeutic target in ASD. A novel modulator of the gut microbiome, the traditionally fermented milk drink kefir, has recently been shown to modulate the microbiota and decrease repetitive behaviour, one of the hallmarks of ASD, in mice. As ...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Marcel van de Wouw Calum J Walsh Giulia M D Vigano Joshua M Lyte Marcus Boehme Andreu Gual-Grau Fiona Crispie Aaron M Walsh Gerard Clarke Timothy G Dinan Paul D Cotter John F Cryan Source Type: research

The association between plasma Tryptophan Catabolites and Depression: the role of Symptom Profiles and Inflammation
We examined the association of TRYCATs levels with 1) the presence of Major Depressive Disorder (MDD), 2) depressive symptom profiles and 3) inflammatory markers.METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n=1100) or remitted (n=753) MDD DSM-IV diagnosis and healthy controls (n=642). Plasma levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KynA), quinolinic acid (QA), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) were measured. Atypical/energy-related symptom (AES), melancholic symptom (MS) and anxious-distress sym...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Yuri Milaneschi Kelly A Allers Aartjan Tf Beekman Erik J Giltay Sascha Keller Robert A Schoevers Sigurd D S üssmuth Heiko G Niessen Brenda W J H Penninx Source Type: research

Kefir Ameliorates Specific Microbiota-Gut-Brain Axis Impairments in a Mouse Model Relevant to Autism Spectrum Disorder
Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00268-3. doi: 10.1016/j.bbi.2021.07.004. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There is a great need for more effective strategies to improve quality of life in ASD subjects. The gut microbiome has emerged as a potential therapeutic target in ASD. A novel modulator of the gut microbiome, the traditionally fermented milk drink kefir, has recently been shown to modulate the microbiota and decrease repetitive behaviour, one of the hallmarks of ASD, in mice. As ...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Marcel van de Wouw Calum J Walsh Giulia M D Vigano Joshua M Lyte Marcus Boehme Andreu Gual-Grau Fiona Crispie Aaron M Walsh Gerard Clarke Timothy G Dinan Paul D Cotter John F Cryan Source Type: research

The association between plasma Tryptophan Catabolites and Depression: the role of Symptom Profiles and Inflammation
We examined the association of TRYCATs levels with 1) the presence of Major Depressive Disorder (MDD), 2) depressive symptom profiles and 3) inflammatory markers.METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n=1100) or remitted (n=753) MDD DSM-IV diagnosis and healthy controls (n=642). Plasma levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KynA), quinolinic acid (QA), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) were measured. Atypical/energy-related symptom (AES), melancholic symptom (MS) and anxious-distress sym...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Yuri Milaneschi Kelly A Allers Aartjan Tf Beekman Erik J Giltay Sascha Keller Robert A Schoevers Sigurd D S üssmuth Heiko G Niessen Brenda W J H Penninx Source Type: research

Kefir Ameliorates Specific Microbiota-Gut-Brain Axis Impairments in a Mouse Model Relevant to Autism Spectrum Disorder
Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00268-3. doi: 10.1016/j.bbi.2021.07.004. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There is a great need for more effective strategies to improve quality of life in ASD subjects. The gut microbiome has emerged as a potential therapeutic target in ASD. A novel modulator of the gut microbiome, the traditionally fermented milk drink kefir, has recently been shown to modulate the microbiota and decrease repetitive behaviour, one of the hallmarks of ASD, in mice. As ...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Marcel van de Wouw Calum J Walsh Giulia M D Vigano Joshua M Lyte Marcus Boehme Andreu Gual-Grau Fiona Crispie Aaron M Walsh Gerard Clarke Timothy G Dinan Paul D Cotter John F Cryan Source Type: research

The association between plasma Tryptophan Catabolites and Depression: the role of Symptom Profiles and Inflammation
We examined the association of TRYCATs levels with 1) the presence of Major Depressive Disorder (MDD), 2) depressive symptom profiles and 3) inflammatory markers.METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n=1100) or remitted (n=753) MDD DSM-IV diagnosis and healthy controls (n=642). Plasma levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KynA), quinolinic acid (QA), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) were measured. Atypical/energy-related symptom (AES), melancholic symptom (MS) and anxious-distress sym...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Yuri Milaneschi Kelly A Allers Aartjan Tf Beekman Erik J Giltay Sascha Keller Robert A Schoevers Sigurd D S üssmuth Heiko G Niessen Brenda W J H Penninx Source Type: research

Kefir Ameliorates Specific Microbiota-Gut-Brain Axis Impairments in a Mouse Model Relevant to Autism Spectrum Disorder
Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00268-3. doi: 10.1016/j.bbi.2021.07.004. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There is a great need for more effective strategies to improve quality of life in ASD subjects. The gut microbiome has emerged as a potential therapeutic target in ASD. A novel modulator of the gut microbiome, the traditionally fermented milk drink kefir, has recently been shown to modulate the microbiota and decrease repetitive behaviour, one of the hallmarks of ASD, in mice. As ...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Marcel van de Wouw Calum J Walsh Giulia M D Vigano Joshua M Lyte Marcus Boehme Andreu Gual-Grau Fiona Crispie Aaron M Walsh Gerard Clarke Timothy G Dinan Paul D Cotter John F Cryan Source Type: research

The association between plasma Tryptophan Catabolites and Depression: the role of Symptom Profiles and Inflammation
We examined the association of TRYCATs levels with 1) the presence of Major Depressive Disorder (MDD), 2) depressive symptom profiles and 3) inflammatory markers.METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n=1100) or remitted (n=753) MDD DSM-IV diagnosis and healthy controls (n=642). Plasma levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KynA), quinolinic acid (QA), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) were measured. Atypical/energy-related symptom (AES), melancholic symptom (MS) and anxious-distress sym...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Yuri Milaneschi Kelly A Allers Aartjan Tf Beekman Erik J Giltay Sascha Keller Robert A Schoevers Sigurd D S üssmuth Heiko G Niessen Brenda W J H Penninx Source Type: research

Kefir Ameliorates Specific Microbiota-Gut-Brain Axis Impairments in a Mouse Model Relevant to Autism Spectrum Disorder
Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00268-3. doi: 10.1016/j.bbi.2021.07.004. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There is a great need for more effective strategies to improve quality of life in ASD subjects. The gut microbiome has emerged as a potential therapeutic target in ASD. A novel modulator of the gut microbiome, the traditionally fermented milk drink kefir, has recently been shown to modulate the microbiota and decrease repetitive behaviour, one of the hallmarks of ASD, in mice. As ...
Source: Brain, Behavior, and Immunity - July 12, 2021 Category: Neurology Authors: Marcel van de Wouw Calum J Walsh Giulia M D Vigano Joshua M Lyte Marcus Boehme Andreu Gual-Grau Fiona Crispie Aaron M Walsh Gerard Clarke Timothy G Dinan Paul D Cotter John F Cryan Source Type: research

GluA3 autoantibodies induce alterations in dendritic spine and behavior in mice
Brain Behav Immun. 2021 Jul 8:S0889-1591(21)00265-8. doi: 10.1016/j.bbi.2021.07.001. Online ahead of print.ABSTRACTAutoantibodies targeting the GluA3 subunit of AMPA receptors (AMPARs) have been found in patients with Rasmussen's encephalitis and different types of epilepsy and were associated with the presence of learning and attention deficits. Our group recently identified the presence of anti-GluA3 immunoglobulin G (IgG) in about 25% of patients with frontotemporal dementia (FTD), thus suggesting a novel pathogenetic role also in chronic neurodegenerative diseases. However, the in vivo behavioral, molecular and morphol...
Source: Brain, Behavior, and Immunity - July 11, 2021 Category: Neurology Authors: Diego Scheggia Jennifer Stanic Maria Italia Filippo La Greca Elisa Zianni Alberto Benussi Barbara Borroni Monica Di Luca Fabrizio Gardoni Source Type: research

GluA3 autoantibodies induce alterations in dendritic spine and behavior in mice
Brain Behav Immun. 2021 Jul 8:S0889-1591(21)00265-8. doi: 10.1016/j.bbi.2021.07.001. Online ahead of print.ABSTRACTAutoantibodies targeting the GluA3 subunit of AMPA receptors (AMPARs) have been found in patients with Rasmussen's encephalitis and different types of epilepsy and were associated with the presence of learning and attention deficits. Our group recently identified the presence of anti-GluA3 immunoglobulin G (IgG) in about 25% of patients with frontotemporal dementia (FTD), thus suggesting a novel pathogenetic role also in chronic neurodegenerative diseases. However, the in vivo behavioral, molecular and morphol...
Source: Brain, Behavior, and Immunity - July 11, 2021 Category: Neurology Authors: Diego Scheggia Jennifer Stanic Maria Italia Filippo La Greca Elisa Zianni Alberto Benussi Barbara Borroni Monica Di Luca Fabrizio Gardoni Source Type: research

Kefir Ameliorates Specific Microbiota-Gut-Brain Axis Impairments in a Mouse Model Relevant to Autism Spectrum Disorder
Publication date: Available online 9 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Marcel van de Wouw, Calum J. Walsh, Giulia M.D. Vigano, Joshua M. Lyte, Marcus Boehme, Andreu Gual-Grau, Fiona Crispie, Aaron M. Walsh, Gerard Clarke, Timothy G. Dinan, Paul D. Cotter, John F. Cryan (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 10, 2021 Category: Neurology Source Type: research

The association between plasma Tryptophan Catabolites and Depression: the role of Symptom Profiles and Inflammation
Publication date: Available online 9 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Yuri Milaneschi, Kelly A. Allers, Aartjan TF Beekman, Erik J Giltay, Sascha Keller, Robert A Schoevers, Sigurd D. Süssmuth, Heiko G. Niessen, Brenda W. J. H. Penninx (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 10, 2021 Category: Neurology Source Type: research

Moderate, Intermittent Voluntary Exercise in a Model of Gulf War Illness Improves Cognitive and Mood Function with Alleviation of Activated Microglia and Astrocytes, and Enhanced Neurogenesis in the Hippocampus
Brain Behav Immun. 2021 Jul 7:S0889-1591(21)00269-5. doi: 10.1016/j.bbi.2021.07.005. Online ahead of print.ABSTRACTPersistent cognitive and mood impairments in Gulf War Illness (GWI) are associated with chronic neuroinflammation, typified by hypertrophied astrocytes, activated microglia, and increased proinflammatory mediators in the brain. Using a rat model, we investigated whether a simple lifestyle change such as moderate voluntary physical exercise would improve cognitive and mood function in GWI. Because veterans with GWI exhibit fatigue and post-exertional malaise, we employed an intermittent voluntary running exerci...
Source: Brain, Behavior, and Immunity - July 10, 2021 Category: Neurology Authors: Maheedhar Kodali Vikas Mishra Bharathi Hattiangady Sahithi Attaluri Jenny Jaimes Gonzalez Bing Shuai Ashok K Shetty Source Type: research

Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment
Brain Behav Immun. 2021 Jul 7:S0889-1591(21)00266-X. doi: 10.1016/j.bbi.2021.07.002. Online ahead of print.ABSTRACTLipocalin 2 (LCN2) is a pleiotropic molecule that is induced in the central nervous system (CNS) in several acute and chronic pathologies. The acute induction of LCN2 evolved as a beneficial process, aimed at combating bacterial infection through the sequestration of iron from pathogens, while the role of LCN2 during chronic, non-infectious disease remains unclear, and recent studies suggest that LCN2 is neurotoxic. However, whether LCN2 is sufficient to induce behavioral and cognitive alterations remains uncl...
Source: Brain, Behavior, and Immunity - July 10, 2021 Category: Neurology Authors: Brennan Olson Xinxia Zhu Mason A Norgard Parham Diba Peter R Levasseur Abby C Buenafe Christian Huisman Kevin G Burfeind Katherine A Michaelis Garth Kong Theodore Braun Daniel L Marks Source Type: research

Moderate, Intermittent Voluntary Exercise in a Model of Gulf War Illness Improves Cognitive and Mood Function with Alleviation of Activated Microglia and Astrocytes, and Enhanced Neurogenesis in the Hippocampus
Brain Behav Immun. 2021 Jul 7:S0889-1591(21)00269-5. doi: 10.1016/j.bbi.2021.07.005. Online ahead of print.ABSTRACTPersistent cognitive and mood impairments in Gulf War Illness (GWI) are associated with chronic neuroinflammation, typified by hypertrophied astrocytes, activated microglia, and increased proinflammatory mediators in the brain. Using a rat model, we investigated whether a simple lifestyle change such as moderate voluntary physical exercise would improve cognitive and mood function in GWI. Because veterans with GWI exhibit fatigue and post-exertional malaise, we employed an intermittent voluntary running exerci...
Source: Brain, Behavior, and Immunity - July 10, 2021 Category: Neurology Authors: Maheedhar Kodali Vikas Mishra Bharathi Hattiangady Sahithi Attaluri Jenny Jaimes Gonzalez Bing Shuai Ashok K Shetty Source Type: research

Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment
Brain Behav Immun. 2021 Jul 7:S0889-1591(21)00266-X. doi: 10.1016/j.bbi.2021.07.002. Online ahead of print.ABSTRACTLipocalin 2 (LCN2) is a pleiotropic molecule that is induced in the central nervous system (CNS) in several acute and chronic pathologies. The acute induction of LCN2 evolved as a beneficial process, aimed at combating bacterial infection through the sequestration of iron from pathogens, while the role of LCN2 during chronic, non-infectious disease remains unclear, and recent studies suggest that LCN2 is neurotoxic. However, whether LCN2 is sufficient to induce behavioral and cognitive alterations remains uncl...
Source: Brain, Behavior, and Immunity - July 10, 2021 Category: Neurology Authors: Brennan Olson Xinxia Zhu Mason A Norgard Parham Diba Peter R Levasseur Abby C Buenafe Christian Huisman Kevin G Burfeind Katherine A Michaelis Garth Kong Theodore Braun Daniel L Marks Source Type: research

GluA3 autoantibodies induce alterations in dendritic spine and behavior in mice
Publication date: Available online 9 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Diego Scheggia, Jennifer Stanic, Maria Italia, Filippo La Greca, Elisa Zianni, Alberto Benussi, Barbara Borroni, Monica Di Luca, Fabrizio Gardoni (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 9, 2021 Category: Neurology Source Type: research

Ruminiclostridium 5, Parabacteroides distasonis, and bile acid profile are modulated by prebiotic diet and associate with facilitated sleep/clock realignment after chronic disruption of rhythms
Brain Behav Immun. 2021 Jul 6:S0889-1591(21)00270-1. doi: 10.1016/j.bbi.2021.07.006. Online ahead of print.ABSTRACTChronic disruption of rhythms (CDR) impacts sleep and can result in circadian misalignment of physiological systems, which in turn is associated with increased disease risk. Exposure to repeated or severe stressors also disturbs sleep and diurnal rhythms. Prebiotic nutrients produce favorable changes in gut microbial ecology, the gut metabolome, and reduce several negative impacts of acute severe stressor exposure, including disturbed sleep, core body temperature rhythmicity, and gut microbial dysbiosis. In li...
Source: Brain, Behavior, and Immunity - July 9, 2021 Category: Neurology Authors: Robert S Thompson Michelle Gaffney Shelby Hopkins Tel Kelley Antonio Gonzalez Samuel J Bowers Martha Hotz Vitaterna Fred W Turek Christine L Foxx Christopher A Lowry Fernando Vargas Pieter C Dorrestein Kenneth P Wright Rob Knight Monika Fleshner Source Type: research

Early Life Adversity, Functional Connectivity And Cognitive Performance In Schizophrenia: The Mediating Role Of IL-6
CONCLUSION: This work suggests that previous associations between CT and social cognition may be partly mediated via an increased inflammatory response. IL-6's association with changes in DMN activity further suggest at least one cortical network via which CT related effects on cognition may be transmitted.PMID:34242739 | DOI:10.1016/j.bbi.2021.06.016 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 9, 2021 Category: Neurology Authors: Sinead King Laurena Holleran David Mothersill Saahithh Patlola Karolina Rokita Ross McManus Marcus Keynon Colm McDonald Brian Hallahan Aiden Corvin Derek Morris John Kelly Declan McKernan Gary Donohoe Source Type: research

Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment
Publication date: Available online 8 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Brennan Olson, Xinxia Zhu, Mason A. Norgard, Parham Diba, Peter R. Levasseur, Abby C. Buenafe, Christian Huisman, Kevin G. Burfeind, Katherine A Michaelis, Garth Kong, Theodore Braun, Daniel L. Marks (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 8, 2021 Category: Neurology Source Type: research

Moderate, Intermittent Voluntary Exercise in a Model of Gulf War Illness Improves Cognitive and Mood Function with Alleviation of Activated Microglia and Astrocytes, and Enhanced Neurogenesis in the Hippocampus
Publication date: Available online 8 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Maheedhar Kodali, Vikas Mishra, Bharathi Hattiangady, Sahithi Attaluri, Jenny Jaimes Gonzalez, Bing Shuai, Ashok K. Shetty (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 8, 2021 Category: Neurology Source Type: research

Early Life Adversity, Functional Connectivity And Cognitive Performance In Schizophrenia: The Mediating Role Of IL-6
Publication date: Available online 7 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Sinead King, Laurena Holleran, David Mothersill, Saahithh Patlola, Karolina Rokita, Ross McManus, Marcus Keynon, Colm McDonald, Brian Hallahan, Aiden Corvin, Derek Morris, John Kelly, Declan McKernan, Gary Donohoe (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 7, 2021 Category: Neurology Source Type: research

Ruminiclostridium 5, Parabacteroides distasonis, and bile acid profile are modulated by prebiotic diet and associate with facilitated sleep/clock realignment after chronic disruption of rhythms
Publication date: Available online 7 July 2021Source: Brain, Behavior, and ImmunityAuthor(s): Robert S. Thompson, Michelle Gaffney, Shelby Hopkins, Tel Kelley, Antonio Gonzalez, Samuel J. Bowers, Martha Hotz Vitaterna, Fred W. Turek, Christine L. Foxx, Christopher A. Lowry, Fernando Vargas, Pieter C. Dorrestein, Kenneth P. Wright, Rob Knight, Monika Fleshner (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 7, 2021 Category: Neurology Source Type: research

Linking Stressful Life Events and Chronic Inflammation Using suPAR (Soluble Urokinase Plasminogen Activator Receptor)
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00249-X. doi: 10.1016/j.bbi.2021.06.018. Online ahead of print.ABSTRACTStressful life events have been linked to declining health, and inflammation has been proposed as a physiological mechanism that might explain this association. Using 828 participants from the Dunedin Longitudinal Study, we tested whether people who experienced more stressful life events during adulthood would show elevated systemic inflammation when followed up in midlife, at age 45. We studied three inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), and a newer biomarker, soluble urokin...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Kyle J Bourassa Line J H Rasmussen Andrea Danese Jesper Eugen-Olsen HonaLee Harrington Renate Houts Richie Poulton Sandhya Ramrakha Karen Sugden Ben Williams Terrie E Moffitt Avshalom Caspi Source Type: research

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus
CONCLUSION: Our study is the first to demonstrate that low intrinsic aerobic fitness that is associated with obesity and poor metabolic health is also linked with reduced hippocampal structural plasticity at a young age. Our results also suggest that inflammation of the brain could be one factor mediating the link between obesity and poor cognitive performance.PMID:34224822 | DOI:10.1016/j.bbi.2021.06.017 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Elina M äkinen Sanna Lensu Markus Honkanen Paavo Laitinen Jan Wikgren Lauren G Koch Steven L Britton Heikki Kainulainen Satu Pekkala Miriam S Nokia Source Type: research

Depression-like Behavior Associated with E/I imbalance of mPFC and Amygdala without TRPC Channels in mice of Knockout IL-10 from Microglia
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00246-4. doi: 10.1016/j.bbi.2021.06.015. Online ahead of print.ABSTRACTDepression has a growing impact on public health. Accumulating evidence supports an association between depression and increased immune system activity. IL-10 is a key cytokine that inhibits excessive inflammatory responses and is related to the anti-inflammatory and protective functions of the central nervous system (CNS). Cx3cr1CreERIL-10-/- mice were used in our study. We aimed to identify the role of IL-10 in microglia in depression and anxiety-like behavior. We performed a series of behavioral tests on th...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Liang Yang Chang Liu Weiya Li Yunqing Ma Shiji Huo Ahsawle Ozathaley Jiling Ren Wenjian Yuan Hong Ni Dong Li Jing Zhang Zhaowei Liu Source Type: research

Linking Stressful Life Events and Chronic Inflammation Using suPAR (Soluble Urokinase Plasminogen Activator Receptor)
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00249-X. doi: 10.1016/j.bbi.2021.06.018. Online ahead of print.ABSTRACTStressful life events have been linked to declining health, and inflammation has been proposed as a physiological mechanism that might explain this association. Using 828 participants from the Dunedin Longitudinal Study, we tested whether people who experienced more stressful life events during adulthood would show elevated systemic inflammation when followed up in midlife, at age 45. We studied three inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), and a newer biomarker, soluble urokin...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Kyle J Bourassa Line J H Rasmussen Andrea Danese Jesper Eugen-Olsen HonaLee Harrington Renate Houts Richie Poulton Sandhya Ramrakha Karen Sugden Ben Williams Terrie E Moffitt Avshalom Caspi Source Type: research

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus
CONCLUSION: Our study is the first to demonstrate that low intrinsic aerobic fitness that is associated with obesity and poor metabolic health is also linked with reduced hippocampal structural plasticity at a young age. Our results also suggest that inflammation of the brain could be one factor mediating the link between obesity and poor cognitive performance.PMID:34224822 | DOI:10.1016/j.bbi.2021.06.017 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Elina M äkinen Sanna Lensu Markus Honkanen Paavo Laitinen Jan Wikgren Lauren G Koch Steven L Britton Heikki Kainulainen Satu Pekkala Miriam S Nokia Source Type: research

Depression-like Behavior Associated with E/I imbalance of mPFC and Amygdala without TRPC Channels in mice of Knockout IL-10 from Microglia
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00246-4. doi: 10.1016/j.bbi.2021.06.015. Online ahead of print.ABSTRACTDepression has a growing impact on public health. Accumulating evidence supports an association between depression and increased immune system activity. IL-10 is a key cytokine that inhibits excessive inflammatory responses and is related to the anti-inflammatory and protective functions of the central nervous system (CNS). Cx3cr1CreERIL-10-/- mice were used in our study. We aimed to identify the role of IL-10 in microglia in depression and anxiety-like behavior. We performed a series of behavioral tests on th...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Liang Yang Chang Liu Weiya Li Yunqing Ma Shiji Huo Ahsawle Ozathaley Jiling Ren Wenjian Yuan Hong Ni Dong Li Jing Zhang Zhaowei Liu Source Type: research

Linking Stressful Life Events and Chronic Inflammation Using suPAR (Soluble Urokinase Plasminogen Activator Receptor)
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00249-X. doi: 10.1016/j.bbi.2021.06.018. Online ahead of print.ABSTRACTStressful life events have been linked to declining health, and inflammation has been proposed as a physiological mechanism that might explain this association. Using 828 participants from the Dunedin Longitudinal Study, we tested whether people who experienced more stressful life events during adulthood would show elevated systemic inflammation when followed up in midlife, at age 45. We studied three inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), and a newer biomarker, soluble urokin...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Kyle J Bourassa Line J H Rasmussen Andrea Danese Jesper Eugen-Olsen HonaLee Harrington Renate Houts Richie Poulton Sandhya Ramrakha Karen Sugden Ben Williams Terrie E Moffitt Avshalom Caspi Source Type: research

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus
CONCLUSION: Our study is the first to demonstrate that low intrinsic aerobic fitness that is associated with obesity and poor metabolic health is also linked with reduced hippocampal structural plasticity at a young age. Our results also suggest that inflammation of the brain could be one factor mediating the link between obesity and poor cognitive performance.PMID:34224822 | DOI:10.1016/j.bbi.2021.06.017 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Elina M äkinen Sanna Lensu Markus Honkanen Paavo Laitinen Jan Wikgren Lauren G Koch Steven L Britton Heikki Kainulainen Satu Pekkala Miriam S Nokia Source Type: research

Depression-like Behavior Associated with E/I imbalance of mPFC and Amygdala without TRPC Channels in mice of Knockout IL-10 from Microglia
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00246-4. doi: 10.1016/j.bbi.2021.06.015. Online ahead of print.ABSTRACTDepression has a growing impact on public health. Accumulating evidence supports an association between depression and increased immune system activity. IL-10 is a key cytokine that inhibits excessive inflammatory responses and is related to the anti-inflammatory and protective functions of the central nervous system (CNS). Cx3cr1CreERIL-10-/- mice were used in our study. We aimed to identify the role of IL-10 in microglia in depression and anxiety-like behavior. We performed a series of behavioral tests on th...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Liang Yang Chang Liu Weiya Li Yunqing Ma Shiji Huo Ahsawle Ozathaley Jiling Ren Wenjian Yuan Hong Ni Dong Li Jing Zhang Zhaowei Liu Source Type: research

Linking Stressful Life Events and Chronic Inflammation Using suPAR (Soluble Urokinase Plasminogen Activator Receptor)
Brain Behav Immun. 2021 Jul 2:S0889-1591(21)00249-X. doi: 10.1016/j.bbi.2021.06.018. Online ahead of print.ABSTRACTStressful life events have been linked to declining health, and inflammation has been proposed as a physiological mechanism that might explain this association. Using 828 participants from the Dunedin Longitudinal Study, we tested whether people who experienced more stressful life events during adulthood would show elevated systemic inflammation when followed up in midlife, at age 45. We studied three inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), and a newer biomarker, soluble urokin...
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Kyle J Bourassa Line J H Rasmussen Andrea Danese Jesper Eugen-Olsen HonaLee Harrington Renate Houts Richie Poulton Sandhya Ramrakha Karen Sugden Ben Williams Terrie E Moffitt Avshalom Caspi Source Type: research

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus
CONCLUSION: Our study is the first to demonstrate that low intrinsic aerobic fitness that is associated with obesity and poor metabolic health is also linked with reduced hippocampal structural plasticity at a young age. Our results also suggest that inflammation of the brain could be one factor mediating the link between obesity and poor cognitive performance.PMID:34224822 | DOI:10.1016/j.bbi.2021.06.017 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Elina M äkinen Sanna Lensu Markus Honkanen Paavo Laitinen Jan Wikgren Lauren G Koch Steven L Britton Heikki Kainulainen Satu Pekkala Miriam S Nokia Source Type: research