PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
This study aimed to assess the effects of alirocumab, a monoclonal antibody targeting PCSK9 to lower systemic low-density lipoprotein cholesterol (LDL-C), on central nervous system (CNS) pathology in a rat model of chronic alcohol exposure. Alirocumab (50 mg/kg) or vehicle was administered weekly for six weeks in 32 male rats subjected to a 35 % ethanol liquid diet or a control liquid diet (n = 8 per group). The study evaluated PCSK9 expression, LDL receptor (LDLR) expression, oxidative stress, and neuroinflammatory markers in brain tissues. Chronic ethanol exposure increased PCSK9 expression in the brain, while alirocumab...
Source: Brain, Behavior, and Immunity - April 24, 2024 Category: Neurology Authors: Josephin Wagner Lauren M Park Partha Mukhopadhyay Csaba Matyas Eszter Trojnar Ruslan Damadzic Jeesun Jung Andrew S Bell Lucas A Mavromatis Ali M Hamandi Daniel B Rosoff Leandro F Vendruscolo George F Koob Pal Pacher Falk W Lohoff Source Type: research
Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers
Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Online ahead of print.ABSTRACTMultiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened dep...
Source: Brain, Behavior, and Immunity - April 21, 2024 Category: Neurology Authors: Lisa M Christian Janice K Kiecolt-Glaser Steve W Cole Christin E Burd Annelise A Madison Stephanie J Wilson Ashley E Rosko Source Type: research
Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers
Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Online ahead of print.ABSTRACTMultiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened dep...
Source: Brain, Behavior, and Immunity - April 21, 2024 Category: Neurology Authors: Lisa M Christian Janice K Kiecolt-Glaser Steve W Cole Christin E Burd Annelise A Madison Stephanie J Wilson Ashley E Rosko Source Type: research
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosis of synapses in a mouse model of depression
CONCLUSIONS: The study suggests that the C1q/C3-CR3 complement signaling pathway, which mediates abnormal microglial phagocytosis of synapses, presents a novel potential therapeutic target for depression treatment.PMID:38642614 | DOI:10.1016/j.bbi.2024.04.018 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 20, 2024 Category: Neurology Authors: Qiu-Qin Han Shi-Yu Shen Ling-Feng Liang Xiao-Rong Chen Jin Yu Source Type: research
Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [ < sup > 11 < /sup > C]PBR28 PET correlates with vascular disease measures
Brain Behav Immun. 2024 Apr 18:S0889-1591(24)00359-3. doi: 10.1016/j.bbi.2024.04.015. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship be...
Source: Brain, Behavior, and Immunity - April 20, 2024 Category: Neurology Authors: Michael B VanElzakker Hannah F Bues Ludovica Brusaferri Minhae Kim Deena Saadi Eva-Maria Ratai Darin D Dougherty Marco L Loggia Source Type: research
Mimicking bacterial infection in male mice changes sperm small RNA profiles and multigenerationally alters offspring behavior and physiology
We examined this using C57BL/6J mice. Eight-week-old males (F0) received a single intraperitoneal injection of the bacterial mimetic lipopolysaccharide (LPS: 5 mg/kg) or 0.9 % saline (vehicle control) before mating with naïve females at four weeks post-injection. Comprehensive behavioral assessments were conducted to investigate anxiety, social behaviors, depressive-like behaviors and cognition in both the F1 and F2 generations within the age range of 8 to 14 weeks. Results demonstrated that only female offspring of LPS-exposed fathers exhibited reduced anxiety levels in the light/dark box, large open field, and novelty-s...
Source: Brain, Behavior, and Immunity - April 18, 2024 Category: Neurology Authors: Huan Liao Da Lu Sonali N Reisinger Elizabeth A Kleeman Nicholas van de Garde Carolina Gubert Anthony J Hannan Source Type: research
Ldl-stimulated microglial activation exacerbates ischemic white matter damage
Brain Behav Immun. 2024 Apr 16;119:416-430. doi: 10.1016/j.bbi.2024.04.014. Online ahead of print.ABSTRACTThe role of microglia in triggering the blood-brain barrier (BBB) impairment and white matter damage after chronic cerebral hypoperfusion is unclear. Here we demonstrated that the vessel-adjacent microglia were specifically activated by the leakage of plasma low-density lipoprotein (LDL), which led to BBB breakdown and ischemic demyelination. Interestingly, we found that LDL stimulation enhanced microglial phagocytosis, causing excessive engulfment of myelin debris and resulting in an overwhelming lipid burden in micro...
Source: Brain, Behavior, and Immunity - April 18, 2024 Category: Neurology Authors: Luo-Qi Zhou Yun-Hui Chu Ming-Hao Dong Sheng Yang Man Chen Yue Tang Xiao-Wei Pang Yun-Fan You Long-Jun Wu Wei Wang Chuan Qin Dai-Shi Tian Source Type: research
Spinal neuronal activity and neuroinflammatory component in a mouse model of CFA-induced vestibulodynia
In conclusion, our study provides a comprehensive understanding of the CFA-induced model of vestibulodynia, encompassing behavioral, neurophysiological and neuroinflammatory aspects. These data pave the way to investigate spinal cord first pain plasticity in vestibulodynia.PMID:38636564 | DOI:10.1016/j.bbi.2024.04.012 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 18, 2024 Category: Neurology Authors: Serena Boccella Michela Perrone Antimo Fusco Roozbe Bonsale Rosmara Infantino Silvia Nuzzo Giovanni Pecoraro Federica Ricciardi Andrea Maria Morace Gianluca Petrillo Ilaria Leone Monica Franzese Vito de Novellis Francesca Guida Marco Salvatore Sabatino Ma Source Type: research
Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)
Brain Behav Immun. 2024 Apr 16:S0889-1591(24)00361-1. doi: 10.1016/j.bbi.2024.04.016. Online ahead of print.ABSTRACTMediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood. We assessed the effects of Western versus Mediterranean-like diets on RNAseq-generated transcriptional profiles in lateral temporal cortex and their relationships with longitudinal changes in neuroanatomy, circulating monocyte gene expression, and observations of social isolation and anxiety in 38 socially-housed, middle-aged female cynomolgus macaques (Macac...
Source: Brain, Behavior, and Immunity - April 18, 2024 Category: Neurology Authors: Brett M Frye Jacob D Negrey Corbin S C Johnson Jeongchul Kim Richard A Barcus Samuel N Lockhart Christopher T Whitlow Kenneth L Chiou Noah Snyder-Mackler Thomas J Montine Suzanne Craft Carol A Shively Thomas C Register Source Type: research
Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord
This study aimed to elucidate the cellular and molecular mechanisms underlying the functional changes in foamy Mϕ and their potential implications for SCI. Contusion at T10 level of the spinal cord was induced using a New York University (NYU) impactor (5 g rod from a height of 6.25 mm) in male mice. ABCA1, an ATP-binding cassette transporter expressed by Mϕ, plays a crucial role in lipid efflux from foamy cells. We observed that foamy Mϕ lacking ABCA1 exhibited increased lipid accumulation and a higher presence of lipid-accumulated foamy Mϕ as well as elevated pro-inflammatory response in vitro and in injured spinal c...
Source: Brain, Behavior, and Immunity - April 18, 2024 Category: Neurology Authors: Xi Wang Zhijian Cheng Wenjiao Tai Mingjun Shi Maryam Ayazi Yang Liu Li Sun Caiyong Yu Zhongmin Fan Bin Guo Xijing He Dongming Sun Wise Young Yi Ren Source Type: research
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Brain Behav Immun. 2024 Apr 10;119:286-300. doi: 10.1016/j.bbi.2024.04.009. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive neurological disorder causing memory loss and cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration remain unclear, leading to a lack of effective strategies to prevent dementia. Recent evidence highlights the role of neuroinflammation, particularly involving microglia, in Alzheimer's disease onset and progression. Characterizing the initial phase of Alzheimer's disease can lead to the discovery of new biomarkers and therapeutic targets, facilitat...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Giusy Pizzirusso Efthalia Preka Julen Goikolea Celia Aguilar-Ruiz Patricia Rodriguez-Rodriguez Guillermo Vazquez-Cabrera Simona Laterza Maria Latorre-Leal Francesca Eroli Klas Blomgren Silvia Maioli Per Nilsson Adamantia Fragkopoulou Andr é Fisahn Luis E Source Type: research
Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring
Brain Behav Immun. 2024 Apr 10;119:301-316. doi: 10.1016/j.bbi.2024.04.010. Online ahead of print.ABSTRACTMaternal obesity is associated with an increased risk of psychiatric disorders such as anxiety, depression, schizophrenia and autism spectrum disorder in the offspring. While numerous studies focus on preventive measures targeting the mothers, only a limited number provide practical approaches for addressing the damages once they are already established. We have recently demonstrated the interplay between maternal obesity and treatment with cannabidiol (CBD) on hypothalamic inflammation and metabolic disturbances, howe...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Fernanda da Silva Rodrigues Jeferson Jantsch Gabriel de Farias Fraga Vit ória Luiza de Camargo Milczarski Victor Silva Dias Camila Scheid Josias de Oliveira Merib Marcia Giovernardi Renata Padilha Guedes Source Type: research
Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy
In conclusion, gut-related alterations reflecting a dysfunctional state, occur during epilepsy development in a TLE mouse model. A short-term treatment with rifaximin during the early phase of the disease, reduced seizure duration and neuropathology, and reversed some intestinal changes, strengthening the therapeutic effects of gut-based therapies in epilepsy.PMID:38608741 | DOI:10.1016/j.bbi.2024.04.007 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Valentina Kebede Teresa Ravizza Silvia Balosso Rossella Di Sapia Luca Canali Sara Soldi Serena Galletti Christina Papazlatani Panagiotis A Karas Sotirios Vasileiadis Annalisa Sforzini Laura Pasetto Valentina Bonetto Annamaria Vezzani Loredana Vesci Source Type: research
Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis
We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to asse...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Mattia Campana Vladislav Yakimov Joanna Moussiopoulou Isabel Maurus Lisa L öhrs Florian Raabe Iris J äger Matin Mortazavi Michael E Benros Rose Jeppesen Gerd Meyer Zu H örste Michael Heming Eloi Gin é-Servén Javier Labad Ester Boix Belinda Lennox Kse Source Type: research
Alterations in gut microbiota contribute to cognitive deficits induced by chronic infection of Toxoplasma gondii
Brain Behav Immun. 2024 Apr 10;119:394-407. doi: 10.1016/j.bbi.2024.04.008. Online ahead of print.ABSTRACTChronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive deficits. We found that T. gondii infection induced cognitive deficits in mice, which was characterized by synaptic ultrastructure impairment and neuroinflammation in the hippocampus. Moreover, the infection led to gut microbi...
Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Xiaoying Yang Yuying Zhou Shimin Tan Xiaokang Tian Xianran Meng Yiling Li Beibei Zhou Guihua Zhao Xing Ge Cheng He Wanpeng Cheng Yumei Zhang Kuiyang Zheng Kun Yin Yinghua Yu Wei Pan Source Type: research
