Perioperative inhibition of β-adrenergic andCOX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome
Publication date: Available online 22 May 2018 Source:Brain, Behavior, and Immunity Author(s): Rita Haldar, Lee Shaashua, Hagar Lavon, Yasmin A. Lyons, Oded Zmora, Eran Sharon, Yehudit Birnbaum, Tanir Allweis, Anil K. Sood, Iris Barshack, Steve Cole, Shamgar Ben-Eliyahu Catecholamines and prostaglandins are secreted abundantly during the perioperative period in response to stress and surgery, and were shown by translational studies to promote tumor metastasis. Here, in a phase-II biomarker clinical trial in breast cancer patients (n=38), we tested the combined perioperative use of the β-blocker, propranolol, and the ...
Source: Brain, Behavior, and Immunity - May 22, 2018 Category: Neurology Source Type: research

'Convergence' created psychoneuroimmunology, and is needed again to secure the future of the field.
PMID: 29792984 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 21, 2018 Category: Neurology Authors: Hutchinson MR Tags: Brain Behav Immun Source Type: research

‘Convergence’ created psychoneuroimmunology, and is needed again to secure the future of the field
Publication date: Available online 21 May 2018 Source:Brain, Behavior, and Immunity Author(s): Mark R. Hutchinson (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 21, 2018 Category: Neurology Source Type: research

Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes.
Abstract Prenatal exposure to maternal stress and depression has been identified as a risk factor for adverse behavioral and neurodevelopmental outcomes in early childhood. However, the molecular mechanisms through which maternal psychopathology shapes offspring development remain poorly understood. We applied transcriptome-wide screens to 149 umbilical cord blood samples from neonates born to mothers with posttraumatic stress disorder (PTSD; n=20), depression (n=31) and PTSD with comorbid depression (n=13), compared to carefully matched trauma exposed controls (n=23) and healthy mothers (n=62). Analyses by matern...
Source: Brain, Behavior, and Immunity - May 20, 2018 Category: Neurology Authors: Breen MS, Wingo AP, Koen N, Donald KA, Nicol M, Zar HJ, Ressler KJ, Buxbaum JD, Stein DJ Tags: Brain Behav Immun Source Type: research

The Association of Disease Activity, Pro-Inflammatory Cytokines, and Neurotrophic Factors with Depression in Patients with Rheumatoid Arthritis
Publication date: Available online 19 May 2018 Source:Brain, Behavior, and Immunity Author(s): Yun-Hong Cheon, Seung-Geun Lee, Mingyo Kim, Hyun-Ok Kim, Young Sun Suh, Ki-Soo Park, Rock Bum Kim, Hyun-Su Yang, Ji-Min Kim, Chang-Nam Son, Eun Kyoung Park, Sang-Hyon Kim, Sang-Il Lee Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the a...
Source: Brain, Behavior, and Immunity - May 20, 2018 Category: Neurology Source Type: research

Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes
Publication date: Available online 20 May 2018 Source:Brain, Behavior, and Immunity Author(s): Michael S. Breen, Aliza P. Wingo, Nastassja Koen, Kirsten A. Donald, Mark Nicol, Heather J. Zar, Kerry J. Ressler, Joseph D. Buxbaum, Dan J. Stein Prenatal exposure to maternal stress and depression has been identified as a risk factor for adverse behavioral and neurodevelopmental outcomes in early childhood. However, the molecular mechanisms through which maternal psychopathology shapes offspring development remain poorly understood. We applied transcriptome-wide screens to 149 umbilical cord blood samples from neonates born to...
Source: Brain, Behavior, and Immunity - May 20, 2018 Category: Neurology Source Type: research

Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders.
This study identifies bacterial species that are sensitive to an autism-related mutation, and further suggests a therapeutic potential for probiotic treatment. PMID: 29787855 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Authors: Laure T, Dimitry G, Oren Z, Marcela K, Timothée T, Rasha M, Nir W, Hila BA, Meital NO, Omry K, Evan E Tags: Brain Behav Immun Source Type: research

The Association of Disease Activity, Pro-Inflammatory Cytokines, and Neurotrophic Factors with Depression in Patients with Rheumatoid Arthritis.
Abstract Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression has not been sufficiently investigated. Therefore, we determined the prevalence of depression and risk factors for depression and deterioration of depressive sym...
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Authors: Cheon YH, Lee SG, Kim M, Kim HO, Sun Suh Y, Park KS, Kim RB, Yang HS, Kim JM, Son CN, Kyoung Park E, Kim SH, Lee SI Tags: Brain Behav Immun Source Type: research

High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke.
This study assesses the neuroinflammatory consequences of a peri-adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNFα and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, peri-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middl...
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Authors: Harrell CS, Zainaldin C, McFarlane D, Hyer MM, Stein D, Sayeed I, Neigh GN Tags: Brain Behav Immun Source Type: research

Estrogen deficiency exacerbates A β-induced memory impairment through enhancement of neuroinflammation, amylodogenesis and NF-ĸB activation in ovariectomized mice
Publication date: Available online 18 May 2018 Source:Brain, Behavior, and Immunity Author(s): Jaesuk Yun, In Jun Yeo, Chul Ju Hwang, Dong-Young Choi, Hyung-Sik Im, Ji Youg Kim, Won Rak Choi, Myung Hee Jung, Sang-Bae Han, Jin Tae Hong Estrogen is well known to have a preventative effect in Alzheimer’s disease (AD) pathology. Several studies have demonstrated that nuclear factor kappa-B (NF-ĸB) can contribute to the effects of estrogen on the development of AD. We investigated whether NF-ĸB affects amyloid-beta (Aβ)-induced memory impairment in an estrogen-lacking condition. In the present study, nine-week-old...
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Source Type: research

Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders
This study identifies bacterial species that are sensitive to an autism-related mutation, and further suggests a therapeutic potential for probiotic treatment. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Source Type: research

High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke
This study assesses the neuroinflammatory consequences of a peri-adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNFα and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, peri-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middl...
Source: Brain, Behavior, and Immunity - May 19, 2018 Category: Neurology Source Type: research

Estrogen deficiency exacerbates A β-induced memory impairment through enhancement of neuroinflammation, amylodogenesis and NF-ĸB activation in ovariectomized mice.
Estrogen deficiency exacerbates Aβ-induced memory impairment through enhancement of neuroinflammation, amylodogenesis and NF-ĸB activation in ovariectomized mice. Brain Behav Immun. 2018 May 18;: Authors: Yun J, Yeo IJ, Hwang CJ, Choi DY, Im HS, Kim JY, Choi WR, Jung MH, Han SB, Hong JT Abstract Estrogen is well known to have a preventative effect in Alzheimer's disease (AD) pathology. Several studies have demonstrated that nuclear factor kappa-B (NF-ĸB) can contribute to the effects of estrogen on the development of AD. We investigated whether NF-ĸB affects amyloid-beta (Aβ)-induced memo...
Source: Brain, Behavior, and Immunity - May 18, 2018 Category: Neurology Authors: Yun J, Yeo IJ, Hwang CJ, Choi DY, Im HS, Kim JY, Choi WR, Jung MH, Han SB, Hong JT Tags: Brain Behav Immun Source Type: research

Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort
Conclusion We were unable to confirm previously reported findings, suggesting that individual SNPs are unlikely to be of clinical utility. Further investigations in well powered studies are warranted, which consider genetic heterogeneity according to subdomains of CRF. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 18, 2018 Category: Neurology Source Type: research

Maternal Immune Activation with Staphylococcal Enterotoxin A Produces Unique Behavioral Changes in C57BL/6 Mouse Offspring.
Abstract Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like receptors. However, fewer studies have examined the role of direct activation of maternal T-cells during pregnancy using microbial agents. Bacterial s...
Source: Brain, Behavior, and Immunity - May 14, 2018 Category: Neurology Authors: Glass R, Norton S, Fox N, Kusnecov AW Tags: Brain Behav Immun Source Type: research

Effectiveness of Depression Interventions for People Living with HIV in Sub-Saharan Africa: A Systematic Review & amp; Meta-Analysis of Psychological & amp; Immunological Outcomes
Publication date: Available online 13 May 2018 Source:Brain, Behavior, and Immunity Author(s): Ruth Verity Passchier, Melanie Amna Abas, Ikenna D Ebuenyi, Carmine M Pariante This meta-analytic review evaluated the effectiveness of depression interventions on the psychological and immunological outcomes of people living with HIV in sub-Saharan Africa. 14 studies, yielding 932 participants were eligible. A random-effects models indicated that depression interventions were followed by large reductions in depression scores (effect size = 1.86, 95% CI = 1.71, 2.01, p < 0.01). No significant effect on immune outcome was ...
Source: Brain, Behavior, and Immunity - May 14, 2018 Category: Neurology Source Type: research

Maternal Immune Activation with Staphylococcal Enterotoxin A Produces Unique Behavioral Changes in C57BL/6 Mouse Offspring
Publication date: Available online 14 May 2018 Source:Brain, Behavior, and Immunity Author(s): Ruthy Glass, Sara Norton, Nicholas Fox, Alexander W. Kusnecov Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like receptors....
Source: Brain, Behavior, and Immunity - May 14, 2018 Category: Neurology Source Type: research

Effectiveness of Depression Interventions for People Living with HIV in Sub-Saharan Africa: A Systematic Review & Meta-Analysis of Psychological & Immunological Outcomes.
Effectiveness of Depression Interventions for People Living with HIV in Sub-Saharan Africa: A Systematic Review & Meta-Analysis of Psychological & Immunological Outcomes. Brain Behav Immun. 2018 May 13;: Authors: Passchier RV, Abas MA, Ebuenyi ID, Pariante CM Abstract This meta-analytic review evaluated the effectiveness of depression interventions on the psychological and immunological outcomes of people living with HIV in sub-Saharan Africa. 14 studies, yielding 932 participants were eligible. A random-effects models indicated that depression interventions were followed by large reductions i...
Source: Brain, Behavior, and Immunity - May 13, 2018 Category: Neurology Authors: Passchier RV, Abas MA, Ebuenyi ID, Pariante CM Tags: Brain Behav Immun Source Type: research

Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort.
CONCLUSION: We were unable to confirm previously reported findings, suggesting that individual SNPs are unlikely to be of clinical utility. Further investigations in well powered studies are warranted, which consider genetic heterogeneity according to subdomains of CRF. PMID: 29763737 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 12, 2018 Category: Neurology Authors: Kühl T, Behrens S, Jung A, Obi N, Thöne K, Schmidt ME, Becher H, Chang-Claude J Tags: Brain Behav Immun Source Type: research

Anti-IL17 treatment ameliorates Down syndrome phenotypes in mice.
In this study, we observed an altered neuroinflammatory milieu in the hippocampus of the TS mouse model. Pro-inflammatory mediators that were elevated in the hippocampus of this model included pro-inflammatory cytokine IL17A, which has a fundamental role in mediating brain damage in neuroinflammatory processes. Here, we analyzed the ability of an anti-IL17A antibody to reduce the neuropathological alterations that are present in TS mice during early neurodevelopmental stages (i.e., hippocampal neurogenesis and hypocellularity) or that are aggravated in later-life stages (i.e., cognitive abilities, cholinergic neuronal loss...
Source: Brain, Behavior, and Immunity - May 11, 2018 Category: Neurology Authors: Rueda N, Vidal V, García-Cerro S, Narcís JO, Llorens-Martín M, Corrales A, Lantigua S, Iglesias M, Merino J, Merino R, Martínez-Cué C Tags: Brain Behav Immun Source Type: research

Stress-induced neuroimmune priming in males and females: comparable but not identical.
PMID: 29753849 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 10, 2018 Category: Neurology Authors: Bekhbat M, Neigh GN Tags: Brain Behav Immun Source Type: research

Stress-induced neuroimmune priming in males and females: comparable but not identical
Publication date: Available online 10 May 2018 Source:Brain, Behavior, and Immunity Author(s): Mandakh Bekhbat, Gretchen N. Neigh (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 10, 2018 Category: Neurology Source Type: research

L-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation
Publication date: Available online 8 May 2018 Source:Brain, Behavior, and Immunity Author(s): Danqing Xin, Xili Chu, Xuemei Bai, Weiwei Ma, Hongtao Yuan, Jie Qiu, Changxing Liu, Tong Li, Xin Zhou, Wenqiang Chen, Dexiang Liu, Zhen Wang We previously reported that L-Cysteine, an H2S donor, significantly alleviated brain injury after hypoxia-ischemic (HI) injury in neonatal mice. However, the mechanisms underlying this neuroprotective effect of L-Cysteine against HI insult remain unknown. In the present study, we tested the hypothesis that the protective effects of L-Cysteine are associated with glial responses and autophagy...
Source: Brain, Behavior, and Immunity - May 9, 2018 Category: Neurology Source Type: research

L-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation.
Abstract We previously reported that L-Cysteine, an H2S donor, significantly alleviated brain injury after hypoxia-ischemic (HI) injury in neonatal mice. However, the mechanisms underlying this neuroprotective effect of L-Cysteine against HI insult remain unknown. In the present study, we tested the hypothesis that the protective effects of L-Cysteine are associated with glial responses and autophagy, and L-Cysteine attenuates synaptic injury as well as behavioral deficits resulting from HI. Consistent with our previous findings, we found that treatment with L-Cysteine after HI reduced early brain injury, improved...
Source: Brain, Behavior, and Immunity - May 8, 2018 Category: Neurology Authors: Xin D, Chu X, Bai X, Ma W, Yuan H, Qiu J, Liu C, Li T, Zhou X, Chen W, Liu D, Wang Z Tags: Brain Behav Immun Source Type: research

Low-Grade Inflammation Decreases Emotion Recognition - Evidence from the Vaccination Model of Inflammation.
Abstract The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction. Forty healthy...
Source: Brain, Behavior, and Immunity - May 6, 2018 Category: Neurology Authors: Balter LJ, Hulsken S, Aldred S, Drayson MT, Higgs S, Veldhuijzen van Zanten JJ, Raymond JE, Bosch JA Tags: Brain Behav Immun Source Type: research

Low-Grade Inflammation Decreases Emotion Recognition – Evidence from the Vaccination Model of Inflammation
Publication date: Available online 6 May 2018 Source:Brain, Behavior, and Immunity Author(s): Leonie JT Balter, Sasha Hulsken, Sarah Aldred, Mark T Drayson, Suzanne Higgs, Jet JCS Veldhuijzen van Zanten, Jane E Raymond, Jos A Bosch The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of ‘theory of mind’ (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness...
Source: Brain, Behavior, and Immunity - May 6, 2018 Category: Neurology Source Type: research

Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy.
Abstract Cytokines and chemokines are potent modulators of brain development and as such, dysregulation of the maternal immune system can result in deviations in the fetal cytokine balance, altering the course of typical brain development, and putting the individual on a "pathway to pathology". In the current study, we used a multi-variate approach to evaluate networks of interacting cytokines and investigated whether alterations in the maternal immune milieu could be linked to alcohol-related and alcohol-independent child neurodevelopmental delay. This was achieved through the measurement of 40 cytokine...
Source: Brain, Behavior, and Immunity - May 5, 2018 Category: Neurology Authors: Bodnar TS, Raineki C, Wertelecki W, Yevtushok L, Plotka L, Zymak-Zakutnya N, Honerkamp-Smith G, Wells A, Rolland M, Woodward TS, Coles CD, Kable JA, Chambers CD, Weinberg J Tags: Brain Behav Immun Source Type: research

The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review
Conclusion Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 5, 2018 Category: Neurology Source Type: research

Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy
Publication date: Available online 5 May 2018 Source:Brain, Behavior, and Immunity Author(s): Tamara S. Bodnar, Charlis Raineki, Wladimir Wertelecki, Lyubov Yevtushok, Larisa Plotka, Natalya Zymak-Zakutnya, Gordon Honerkamp-Smith, Alan Wells, Matthieu Rolland, Todd S. Woodward, Claire D. Coles, Julie A. Kable, Christina D. Chambers, Joanne Weinberg Cytokines and chemokines are potent modulators of brain development and as such, dysregulation of the maternal immune system can result in deviations in the fetal cytokine balance, altering the course of typical brain development, and putting the individual on a “pathway ...
Source: Brain, Behavior, and Immunity - May 5, 2018 Category: Neurology Source Type: research

The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review.
CONCLUSION: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. PMID: 29733946 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 4, 2018 Category: Neurology Authors: Drummond JB, Barbosa IG, Dantzer R, Teixeira AL Tags: Brain Behav Immun Source Type: research

Profiling inflammatory signatures of schizophrenia: a cross-sectional and meta-analysis study
Publication date: Available online 3 May 2018 Source:Brain, Behavior, and Immunity Author(s): Dorota Frydecka, Małgorzata Krzystek-Korpacka, Alba Lubeiro, Filip Stramecki, Bartłomiej Stańczykiewicz, Jan Aleksander Beszłej, Patryk Piotrowski, Kamila Kotowicz, Monika Szewczuk-Bogusławska, Edyta Pawlak-Adamska, Błażej Misiak We aimed to profile a broad panel of inflammatory markers in patients with schizophrenia and healthy controls. Additionally, we performed a meta-analysis of chemokine alterations that have not been subjected to quantitative synthesis so far. We recruited 78 patients with schizophrenia and 78 healt...
Source: Brain, Behavior, and Immunity - May 4, 2018 Category: Neurology Source Type: research

Profiling inflammatory signatures of schizophrenia: a cross-sectional and meta-analysis study.
Abstract We aimed to profile a broad panel of inflammatory markers in patients with schizophrenia and healthy controls. Additionally, we performed a meta-analysis of chemokine alterations that have not been subjected to quantitative synthesis so far. We recruited 78 patients with schizophrenia and 78 healthy controls, and measured inflammatory markers using the Luminex technology. After adjustment for multiple testing, we found elevated levels of interleukin(IL)-1 receptor antagonist (IL-1RA), IL-6, IL-7, IL-8, IL-9, IL-10, IL-13, interferon-γ, eotaxin-1, granulocyte-macrophage colony-stimulating factor (GM-...
Source: Brain, Behavior, and Immunity - May 3, 2018 Category: Neurology Authors: Frydecka D, Krzystek-Korpacka M, Lubeiro A, Stramecki F, Stańczykiewicz B, Aleksander Beszłej J, Piotrowski P, Kotowicz K, Szewczuk-Bogusławska M, Pawlak-Adamska E, Misiak B Tags: Brain Behav Immun Source Type: research

Methamphetamine augment HIV-1 Tat mediated memory deficits by altering the expression of synaptic proteins and neurotrophic factors
Publication date: Available online 2 May 2018 Source:Brain, Behavior, and Immunity Author(s): Anantha Ram Nookala, Daniel C. Schwartz, Nitish S. Chaudhari, Alexy Glazyrin, Edward B. Stephens, Nancy E.J. Berman, Anil Kumar Methamphetamine (METH) abuse is common among individuals infected with HIV-1 and has been shown to affect HIV replication and pathogenesis. These HIV-1 infected individuals also exhibit greater neuronal injury and higher cognitive decline. HIV-1 proteins, specifically gp120 and HIV-1 Tat, have been earlier shown to affect neurocognition. HIV-1 Tat, a viral protein released early during HIV-1 replication,...
Source: Brain, Behavior, and Immunity - May 3, 2018 Category: Neurology Source Type: research

Methamphetamine augment HIV-1 Tat mediated memory deficits by altering the expression of synaptic proteins and neurotrophic factors.
Abstract Methamphetamine (METH) abuse is common among individuals infected with HIV-1 and has been shown to affect HIV replication and pathogenesis. These HIV-1 infected individuals also exhibit greater neuronal injury and higher cognitive decline. HIV-1 proteins, specifically gp120 and HIV-1 Tat, have been earlier shown to affect neurocognition. HIV-1 Tat, a viral protein released early during HIV-1 replication, contributes to HIV-associated neurotoxicity through various mechanisms including production of pro-inflammatory cytokines, reactive oxygen species and dysregulation of neuroplasticity. However, the combin...
Source: Brain, Behavior, and Immunity - May 2, 2018 Category: Neurology Authors: Nookala AR, Schwartz DC, Chaudhari NS, Glazyrin A, Stephens EB, Berman NEJ, Kumar A Tags: Brain Behav Immun Source Type: research

White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: combined DTI and immunological investigation in the different phases of bipolar disorder
Conclusions Our data show a combined occurrence of WM and immunological alterations in mania. WM abnormalities highly correlated with reduction in circulating CD8+ T cell subpopulations that are terminally differentiated effector cells prone to tissue migration, suggesting that these T cells could play a role in WM alteration in BD. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 2, 2018 Category: Neurology Source Type: research

White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: combined DTI and immunological investigation in the different phases of bipolar disorder.
CONCLUSIONS: Our data show a combined occurrence of WM and immunological alterations in mania. WM abnormalities highly correlated with reduction in circulating CD8+ T cell subpopulations that are terminally differentiated effector cells prone to tissue migration, suggesting that these T cells could play a role in WM alteration in BD. PMID: 29723656 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 30, 2018 Category: Neurology Authors: Magioncalda P, Martino M, Tardito S, Sterlini B, Conio B, Marozzi V, Adavastro G, Capobianco L, Russo D, Parodi A, Kalli F, Nasi G, Altosole T, Piaggio N, Northoff G, Fenoglio D, Inglese M, Filaci G, Amore M Tags: Brain Behav Immun Source Type: research

Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury.
Abstract N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where their function remains largely unknown. Here, we showed that Cav2.2 was upregulated in the soma of uninjured L4 DRG neurons, but downregulated in those of injured L5 DRG neurons following L5 spinal nerve ligation (L5-SNL). Local application of specific Cav2.2 blockers (ω-conotoxin GVIA, 1-100 μM or ZC88, 10-1000 μM) onto L4 and 6 DRGs on the operated si...
Source: Brain, Behavior, and Immunity - April 27, 2018 Category: Neurology Authors: Yang J, Xie MX, Hu L, Wang XF, Mai JZ, Li YY, Wu N, Zhang C, Li J, Pang RP, Liu XG Tags: Brain Behav Immun Source Type: research

Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin
In this study, we aimed to investigate the mechanism of ACR-induced spatial memory impairment and the beneficial effect of curcumin. ACR exposure at 10 mg/kg/d for 7 weeks caused slight gait abnormality and spatial memory deficits, which was associated with an activation of glial cells, a reduction of phosphorylated cAMP response elements binding protein (P-CREB) and an aggregation of hyperphosphorylated tau including p-tau (Ser262), AT8 (p-tau Ser202/Thr205) and PHF1 (p-tau Ser396/404) in the hippocampus and cortex. ACR markedly regulate the expression of glycogen synthase kinase-3β (GSK-3β) and cyclin-depen...
Source: Brain, Behavior, and Immunity - April 27, 2018 Category: Neurology Source Type: research

Comparative aspects and evolutionary perspectives of behavioral fever: Or what can we learn from fish?
Publication date: Available online 26 April 2018 Source:Brain, Behavior, and Immunity Author(s): Christoph Rummel (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 27, 2018 Category: Neurology Source Type: research

Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury
Publication date: Available online 27 April 2018 Source:Brain, Behavior, and Immunity Author(s): Jie Yang, Man-Xiu Xie, Li Hu, Xiao-Fang Wang, Jie-Zhen Mai, Yong-Yong Li, Ning Wu, Cheng Zhang, Jin Li, Rui-Ping Pang, Xian-Guo Liu N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where their function remains largely unknown. Here, we showed that Cav2.2 was upregulated in the soma of uninjured L4 DRG neurons, but downregulated in those of inju...
Source: Brain, Behavior, and Immunity - April 27, 2018 Category: Neurology Source Type: research

Comparative aspects and evolutionary perspectives of behavioral fever: or what can we learn from fish?
PMID: 29705072 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 26, 2018 Category: Neurology Authors: Rummel C Tags: Brain Behav Immun Source Type: research

Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin.
In this study, we aimed to investigate the mechanism of ACR-induced spatial memory impairment and the beneficial effect of curcumin. ACR exposure at 10 mg/kg/d for 7 weeks caused slight gait abnormality and spatial memory deficits, which was associated with an activation of glial cells, a reduction of phosphorylated cAMP response elements binding protein (P-CREB) and an aggregation of hyperphosphorylated tau including p-tau (Ser262), AT8 (p-tau Ser202/Thr205) and PHF1 (p-tau Ser396/404) in the hippocampus and cortex. ACR markedly regulate the expression of glycogen synthase kinase-3β (GSK-3β) and cyclin-depen...
Source: Brain, Behavior, and Immunity - April 26, 2018 Category: Neurology Authors: Yan D, Yao J, Liu Y, Zhang X, Wang Y, Chen X, Liu L, Shi N, Yan H Tags: Brain Behav Immun Source Type: research

Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide- induced spatial memory impairment: Suppression by curcumin
In this study, we aimed to investigate the mechanism of ACR- induced spatial memory impairment and the beneficial effect of curcumin. ACR exposure at 10 mg/kg/d for 7 weeks caused slight gait abnormality and spatial memory deficits, which was associated with an activation of glial cells, a reduction of phosphorylated cAMP response elements binding protein (P-CREB) and an aggregation of hyperphosphorylated tau including p-tau (Ser262), AT8 (p-tau Ser202/Thr205) and PHF1 (p-tau Ser396/404) in the hippocampus and cortex. ACR markedly regulate the expression of glycogen synthase kinase-3β (GSK-3β) and cyclin-dependen...
Source: Brain, Behavior, and Immunity - April 26, 2018 Category: Neurology Source Type: research

Distinct characteristics of hippocampal pathogenic TH17 cells in a mouse model of depression
Publication date: Available online 24 April 2018 Source:Brain, Behavior, and Immunity Author(s): Eléonore Beurel, Jeffrey Lowell, Richard Jope Increasing evidence indicates that multiple actions of the immune system are closely intertwined with the development of depression and subsequent recovery processes. One of these interactions is substantial evidence that the TH17 subtype of CD4+ T cells promotes susceptibility to depression-like behaviors in rodents. Comparing subtypes of CD4+ T cells, we found that administration of TH17 cells, but not TH1 cells or TREGS, promoted susceptibility to learned-helplessness dep...
Source: Brain, Behavior, and Immunity - April 25, 2018 Category: Neurology Source Type: research

From the Head of a Caterpillar: A Possible Treatment for Neuropsychiatric Sequelae of Autoimmune Disease
Publication date: Available online 23 April 2018 Source:Brain, Behavior, and Immunity Author(s): Alexander W. Kusnecov (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 24, 2018 Category: Neurology Source Type: research

Distinct characteristics of hippocampal pathogenic TH17 cells in a mouse model of depression.
Abstract Increasing evidence indicates that multiple actions of the immune system are closely intertwined with the development of depression and subsequent recovery processes. One of these interactions is substantial evidence that the TH17 subtype of CD4+ T cells promotes susceptibility to depression-like behaviors in rodents. Comparing subtypes of CD4+ T cells, we found that administration of TH17 cells, but not TH1 cells or TREGS, promoted susceptibility to learned-helplessness depressive-like behavior and accumulated in the hippocampus of learned helpless mice. Adoptively transferred TH17 cells into Rag2-/- mic...
Source: Brain, Behavior, and Immunity - April 23, 2018 Category: Neurology Authors: Beurel E, Lowell J, Jope R Tags: Brain Behav Immun Source Type: research

From the Head of a Caterpillar: A Possible Treatment for Neuropsychiatric Sequelae of Autoimmune Disease.
PMID: 29698708 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 23, 2018 Category: Neurology Authors: Kusnecov AW Tags: Brain Behav Immun Source Type: research

Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1 α abundance in rats following focal cerebral ischaemia
In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA tranfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis an...
Source: Brain, Behavior, and Immunity - April 19, 2018 Category: Neurology Source Type: research

Recent Stimulant Use and Leukocyte Gene Expression In Methamphetamine Users with Treated HIV Infection.
Abstract Stimulant use may accelerate HIV disease progression through biological and behavioral pathways. However, scant research with treated HIV-positive persons has examined stimulant-associated alterations in pathophysiologic processes relevant to HIV pathogenesis. In a sample of 55 HIV-positive, methamphetamine-using sexual minority men with a viral load less than 200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene expression in participants who had a urine sample that was reactive for stimulants (n = 27) as compared to those who tested non-reactive (n = 28). Results indicated dif...
Source: Brain, Behavior, and Immunity - April 18, 2018 Category: Neurology Authors: Carrico AW, Flentje A, Kober K, Lee S, Hunt P, Riley ED, Shoptaw S, Flowers RNE, Dilworth SE, Pahwa S, Aouizerat BE Tags: Brain Behav Immun Source Type: research

Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1 α abundance in rats following focal cerebral ischaemia.
In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA tranfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis an...
Source: Brain, Behavior, and Immunity - April 18, 2018 Category: Neurology Authors: Chen X, Zhang X, Chen T, Jiang X, Wang X, Lei H, Wang Y Tags: Brain Behav Immun Source Type: research