Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases Comorbid Major Depressive Disorder (MDD)- Results from a Randomized Controlled Trial
Publication date: Available online 19 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jane Pei- Chen Chang, Shih-Sheng Chang, Hui-Ting Yang, Hui-Ting Chen, Yu-Chuan Chien, Bo Yang, Huanxing Su, Kuan-Pin SuAbstractInsstroductionCardiovascular diseases (CVDs) and major depressive disorder (MDD) will be the two most disabling diseases by 2030. Patients with CVDs comorbid depression had lower levels of total omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA), and a higher omega-6 to omega-3 ratio. However, there have been limited studies on the effects n-3 PUFAs on MDD in patients with CVDs.M...
Source: Brain, Behavior, and Immunity - March 20, 2019 Category: Neurology Source Type: research

Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between-, within-person associations in a longitudinal study of older adults
Publication date: Available online 15 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. SegerstromAbstractCytomegalovirus (CMV) and psychological stress are implicated as drivers of immunological aging. It is unknown, however, whether associations among CMV titers, stress, and immune aging are more stable or dynamic over time. The present investigation tested the between-person (stable differences) and within-person (dynamic fluctuations) associations of CMV titers and perceived stress on late-differentiated T and natural killer (NK) p...
Source: Brain, Behavior, and Immunity - March 16, 2019 Category: Neurology Source Type: research

Apical splenic nerve electrical stimulation discloses an anti-inflammatory pathway relying on adrenergic and nicotinic receptors in myeloid cells
Publication date: Available online 15 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Mélanie Guyot, Thomas Simon, Clara Panzolini, Franck Ceppo, Douglas Daoudlarian, Emilie Murris, Eric Macia, Sophie Abélanet, Arun Sridhar, Margriet J. Vervoordeldonk, Nicolas Glaichenhaus, Philippe BlancouAbstractThe autonomic nervous system innervates all lymphoid tissues including the spleen therefore providing a link between the central nervous system and the immune system. The only known mechanism of neural inhibition of inflammation in the spleen relies on the production of norepinephrine by splenic catecholam...
Source: Brain, Behavior, and Immunity - March 16, 2019 Category: Neurology Source Type: research

The burden of being poor: Stress at the belly of the matter
Publication date: Available online 16 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Ashley E. Mason (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 16, 2019 Category: Neurology Source Type: research

Methamphetamine-associated cognitive decline is attenuated by neutralizing il-1 signaling
Publication date: Available online 15 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Arkadiusz Liśkiewicz, Marta Przybyła, Minseon Park, Daniela Liśkiewicz, Marta Nowacka-Chmielewska, Andrzej Małecki, Jarosław Barski, Joanna Lewin-Kowalik, Michal ToborekAbstractMethamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokines are among the key mediators between systemic inflammatory status and tissue responses. One of these, interleuk...
Source: Brain, Behavior, and Immunity - March 16, 2019 Category: Neurology Source Type: research

Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation
In this study, we sought to determine if central serotonin (5-HT) plays a role in SI induced by intravenous administration of LPS (1.5 mg/kg) in male Wistar rats (280-350 g) by assessing 5-HT levels in the AVPO, mean arterial pressure, heart rate, and Tb up to 300 min after LPS administration, as well as assessing plasma and spleen cytokine levels, nitric oxide (NO) plasma levels, and prostaglandin (PG) E2 levels in the AVPO at 75 min and 300 min after LPS administration. We observed reduced AVPO 5-HT levels, hypotension, tachycardia, hypothermia followed by fever, as well as observing increased plasma NO, plasma and splee...
Source: Brain, Behavior, and Immunity - March 16, 2019 Category: Neurology Source Type: research

Methamphetamine-associated cognitive decline is attenuated by neutralizing il-1 signaling.
Abstract Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokines are among the key mediators between systemic inflammatory status and tissue responses. One of these, interleukin 1 (IL-1), has been hypothesized to be involved in cognitive functions and also appears to play a pivotal role among inflammatory molecules. In the present study, we demonstrate that exposure of mice to METH markedly increased the protein level of IL-1β...
Source: Brain, Behavior, and Immunity - March 15, 2019 Category: Neurology Authors: Liśkiewicz A, Przybyła M, Park M, Liśkiewicz D, Nowacka-Chmielewska M, Małecki A, Barski J, Lewin-Kowalik J, Toborek M Tags: Brain Behav Immun Source Type: research

Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation.
In this study, we sought to determine if central serotonin (5-HT) plays a role in SI induced by intravenous administration of LPS (1.5 mg/kg) in male Wistar rats (280-350 g) by assessing 5-HT levels in the AVPO, mean arterial pressure, heart rate, and Tb up to 300 min after LPS administration, as well as assessing plasma and spleen cytokine levels, nitric oxide (NO) plasma levels, and prostaglandin (PG) E2 levels in the AVPO at 75 min and 300 min after LPS administration. We observed reduced AVPO 5-HT levels, hypotension, tachycardia, hypothermia followed by fever, as well as observing increased plasma NO, plasma and splee...
Source: Brain, Behavior, and Immunity - March 15, 2019 Category: Neurology Authors: Mota CMD, Borges GS, Amorim MR, Carolino ROG, Batalhão ME, Anselmo-Franci JA, Carnio EC, Branco LGS Tags: Brain Behav Immun Source Type: research

The burden of being poor: Stress at the belly of the matter.
PMID: 30885842 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 15, 2019 Category: Neurology Authors: Mason AE Tags: Brain Behav Immun Source Type: research

Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between-, within-person associations in a longitudinal study of older adults.
Abstract Cytomegalovirus (CMV) and psychological stress are implicated as drivers of immunological aging. It is unknown, however, whether associations among CMV titers, stress, and immune aging are more stable or dynamic over time. The present investigation tested the between-person (stable differences) and within-person (dynamic fluctuations) associations of CMV titers and perceived stress on late-differentiated T and natural killer (NK) peripheral blood cells in a longitudinal study of older adults aged 64-92 years (N=149). Participants reported stress levels and provided blood biannually for 2.5 years (up to 5 ...
Source: Brain, Behavior, and Immunity - March 15, 2019 Category: Neurology Authors: Reed RG, Presnell SR, Al-Attar A, Lutz CT, Segerstrom SC Tags: Brain Behav Immun Source Type: research

Apical splenic nerve electrical stimulation discloses an anti-inflammatory pathway relying on adrenergic and nicotinic receptors in myeloid cells.
cou P Abstract The autonomic nervous system innervates all lymphoid tissues including the spleen therefore providing a link between the central nervous system and the immune system. The only known mechanism of neural inhibition of inflammation in the spleen relies on the production of norepinephrine by splenic catecholaminergic fibers which binds to β2-adrenergic receptors (β 2-ARs) of CD4+ T cells. These CD4+ T cells trigger the release of acetylcholine that inhibits the secretion of inflammatory cytokines by macrophages through α7 nicotinic acetylcholine receptor (α7nAchRs) signaling. While...
Source: Brain, Behavior, and Immunity - March 15, 2019 Category: Neurology Authors: Guyot M, Simon T, Panzolini C, Ceppo F, Daoudlarian D, Murris E, Macia E, Abélanet S, Sridhar A, Vervoordeldonk MJ, Glaichenhaus N, Blancou P Tags: Brain Behav Immun Source Type: research

What’s the meaning of this? Childhood socioeconomic status, inflammation, and meta-analysis
Publication date: Available online 13 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Suzanne C. SegerstromAbstractIn an idealized world, a meta-analysis consolidates the literature, providing an “answer” to a question asked repeatedly by primary studies. However, in the real world, a meta-analysis can raise as many questions as it answers. Such is the case in this well-done meta-analysis of the literature correlating childhood socioeconomic status (SES) and inflammatory biomarkers (Milaniak & Jaffee, 2019). (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 13, 2019 Category: Neurology Source Type: research

The Goddess Who Spins the Thread of Life: Klotho, Psychiatric Stress, and Accelerated Aging
ConclusionsRs9315202 predicted multiple biomarkers of cellular aging such that psychiatric stress was more strongly associated with cellular aging in those with the minor allele. KL genotype may contribute to a synchronized pathological aging response to stress and could be a therapeutic target to alter the pace of cellular aging. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 13, 2019 Category: Neurology Source Type: research

What's the meaning of this? Childhood socioeconomic status, inflammation, and meta-analysis.
Abstract In an idealized world, a meta-analysis consolidates the literature, providing an "answer" to a question asked repeatedly by primary studies. However, in the real world, a meta-analysis can raise as many questions as it answers. Such is the case in this well-done meta-analysis of the literature correlating childhood socioeconomic status (SES) and inflammatory biomarkers (Milaniak & Jaffee, 2019). PMID: 30878685 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 13, 2019 Category: Neurology Authors: Segerstrom SC Tags: Brain Behav Immun Source Type: research

HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis
Publication date: Available online 11 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Palsamy Periyasamy, Annadurai Thangaraj, Venkata Sunil Bendi, Shilpa BuchAbstractWhile the advent of combination antiretroviral therapy (cART) has dramatically increased the lifespan of people living with HIV-1 paradoxically, the prevalence of NeuroHIV in people treated with cART is on the rise. It has been well documented that despite the effectiveness of cART in suppressing viremia, CNS continues to harbor viral reservoirs with persistent low-level virus replication. This, in turn, leads to the presence and accumulation of ear...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Source Type: research

Neuroimmunology of the female brain across the lifespan: plasticity to psychopathology
Publication date: Available online 11 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): R.M. Barrientos, PJ Brunton, KM Lenz, L Pyter, S.J. SpencerAbstractThe female brain is highly dynamic and can fundamentally remodel throughout the normal ovarian cycle as well as in critical life stages including perinatal development, pregnancy and old-age. As such, females are particularly vulnerable to infections, psychological disorders, certain cancers, and cognitive impairments. We will present the latest evidence on the female brain; how it develops through the neonatal period; how it changes through the ovarian cycle in ...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Source Type: research

Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients
ConclusionsCHC patients exhibited increased perceived stress and depressive symptoms, which were associated with changes in inflammatory marker levels and in functional connectivity between the insula and putamen, areas involved in interoceptive integration, emotional awareness, and orientation of motivational state. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Source Type: research

Heart Rate Variability and Inflammation: A Meta-Analysis of Human Studies
Publication date: Available online 11 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): DeWayne P. Williams, Julian Koenig, Luca Carnevali, Andrea Sgoifo, Marc N. Jarczok, Esther M. Sternberg, Julian F. ThayerAbstractThe inflammatory reflex is known as the body’s primary defense against infection and has been implicated in a number of diseases. The magnitude of the inflammatory response is important, as an extreme or insufficient response can be differentially harmful to the individual. Converging evidence suggests that the autonomic nervous system (ANS) regulates the inflammatory reflex. Heart rate variabili...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Source Type: research

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
We examined the effects of multifactorial early-life adversity on behavior and microbiota composition in C3H/HeN mice of both sexes exposed to a combination of maternal immune activation, maternal separation (3hr per day from postnatal day (PND)2 to PND14) and maternal unpredictable chronic mild stress. At adulthood, offspring exposed to multi-hit early adversity showed sex-specific behavioral phenotypes with males exhibiting deficits in social behavior and females showing increased anxiety and compulsive behavior in the elevated plus maze and marble burying tests. Early adversity also differentially regulated gene express...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Source Type: research

HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NF κB signaling axis.
HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis. Brain Behav Immun. 2019 Mar 11;: Authors: Periyasamy P, Thangaraj A, Bendi VS, Buch S Abstract While the advent of combination antiretroviral therapy (cART) has dramatically increased the lifespan of people living with HIV-1 paradoxically, the prevalence of NeuroHIV in people treated with cART is on the rise. It has been well documented that despite the effectiveness of cART in suppressing viremia, CNS continues to harbor viral reservoirs with persistent low-level virus replication. This, in turn, le...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Authors: Periyasamy P, Thangaraj A, Bendi VS, Buch S Tags: Brain Behav Immun Source Type: research

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner.
We examined the effects of multifactorial early-life adversity on behavior and microbiota composition in C3H/HeN mice of both sexes exposed to a combination of maternal immune activation, maternal separation (3hr per day from postnatal day (PND)2 to PND14) and maternal unpredictable chronic mild stress. At adulthood, offspring exposed to multi-hit early adversity showed sex-specific behavioral phenotypes with males exhibiting deficits in social behavior and females showing increased anxiety and compulsive behavior in the elevated plus maze and marble burying tests. Early adversity also differentially regulated gene express...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Authors: Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, de Oliveira CM, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M Tags: Brain Behav Immun Source Type: research

Heart Rate Variability and Inflammation: A Meta-Analysis of Human Studies.
Abstract The inflammatory reflex is known as the body's primary defense against infection and has been implicated in a number of diseases. The magnitude of the inflammatory response is important, as an extreme or insufficient response can be differentially harmful to the individual. Converging evidence suggests that the autonomic nervous system (ANS) regulates the inflammatory reflex. Heart rate variability (HRV) can be separated into components that primarily reflect parasympathetic (PNS) or vagal activity (i.e., indices of vagally mediated HRV) and a combination of both sympathetic (SNS) and PNS influences. Give...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Authors: Williams DP, Koenig J, Carnevali L, Sgoifo A, Jarczok MN, Sternberg EM, Thayer JF Tags: Brain Behav Immun Source Type: research

The Goddess Who Spins the Thread of Life: Klotho, Psychiatric Stress, and Accelerated Aging.
CONCLUSIONS: Rs9315202 predicted multiple biomarkers of cellular aging such that psychiatric stress was more strongly associated with cellular aging in those with the minor allele. KL genotype may contribute to a synchronized pathological aging response to stress and could be a therapeutic target to alter the pace of cellular aging. PMID: 30872092 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Authors: Wolf EJ, Morrison FG, Sullivan DR, Logue MW, Guetta RE, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Miller MW Tags: Brain Behav Immun Source Type: research

Neuroimmunology of the female brain across the lifespan: plasticity to psychopathology.
Abstract The female brain is highly dynamic and can fundamentally remodel throughout the normal ovarian cycle as well as in critical life stages including perinatal development, pregnancy and old-age. As such, females are particularly vulnerable to infections, psychological disorders, certain cancers, and cognitive impairments. We will present the latest evidence on the female brain; how it develops through the neonatal period; how it changes through the ovarian cycle in normal individuals; how it adapts to pregnancy and postpartum; how it responds to illness and disease, particularly cancer; and, finally, how it ...
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Authors: Barrientos RM, Brunton PJ, Lenz KM, Pyter L, Spencer SJ Tags: Brain Behav Immun Source Type: research

Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients.
CONCLUSIONS: CHC patients exhibited increased perceived stress and depressive symptoms, which were associated with changes in inflammatory marker levels and in functional connectivity between the insula and putamen, areas involved in interoceptive integration, emotional awareness, and orientation of motivational state. PMID: 30872094 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 11, 2019 Category: Neurology Authors: Giovanni O, Laura BH, Ricard N, Zoe M, David MH, Myriam C, Dolors G, Javier C, Lucile C, Xavier F, Jesus P, Ricard S, Rocio MS Tags: Brain Behav Immun Source Type: research

Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington’s disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors
In this study, we investigated whether GT could ameliorate the neurological impairment and striatal toxicity in cellular or animal model of HD. Pre-, co-, and onset-treatment with GT (25, 50, or 100 mg/kg/day, p.o.) alleviated the severity of neurological impairment and lethality following 3-nitropropionic acid (3-NPA). Pretreatment with GT also attenuated mitochondrial dysfunction i.e. succinate dehydrogenase and MitoSOX activities, apoptosis, microglial activation, and mRNA expression of inflammatory mediators i.e. IL-1β, IL-6, TNF-α, COX-2, and iNOS in the striatum after 3-NPA-intoxication. Its action mechani...
Source: Brain, Behavior, and Immunity - March 9, 2019 Category: Neurology Source Type: research

Sex similarities in the immune response to social stress
Publication date: Available online 6 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Georgia E. Hodes (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 7, 2019 Category: Neurology Source Type: research

Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety
ConclusionRMT treatment is able to restore phase-shifted melatonin markers, normalized the altered expression of the circadian genes, the levels of inflammatory cytokines and neurotrophins in patients with insomnia comorbid anxiety and depression. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 7, 2019 Category: Neurology Source Type: research

Depressive Symptoms and Immune Transcriptional Profiles in Late Adolescents
Publication date: Available online 6 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jessica J. Chiang, Steve W. Cole, Julienne E. Bower, Michael R. Irwin, Shelley E. Taylor, Jesusa Arevalo, Andrew J. FuligniAbstractBackgroundRates of depression increase and peak during late adolescence and alterations in immune processes are thought to be both a risk factor and outcome of depression. However, few studies have examined depression-immune dynamics among adolescents. Using a functional genomics approach, the current study examined whether depressive symptoms were associated with activation with a gene expression pro...
Source: Brain, Behavior, and Immunity - March 7, 2019 Category: Neurology Source Type: research

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury
Publication date: Available online 6 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Daniela Sommer, Inge Corstjens, Selien Sanchez, Dearbhaile Dooley, Stefanie Lemmens, Jana Van Broeckhoven, Jeroen Bogie, Tim Vanmierlo, Pia M Vidal, Stefan Rose-John, Myriam Gou-Fabregas, Sven HendrixAbstractA disintegrin and metalloproteinase 17 (ADAM17) is the major sheddase involved in the cleavage of a plethora of cytokines, cytokine receptors and growth factors, thereby playing a substantial role in inflammatory and regenerative processes after central nervous system trauma. By making use of a hypomorphic ADAM17 knockin mous...
Source: Brain, Behavior, and Immunity - March 7, 2019 Category: Neurology Source Type: research

Deleterious synergistic effects of distress and surgery on cancer metastasis: Abolishment through an integrated perioperative immune-stimulating stress-inflammatory-reducing intervention
Publication date: Available online 6 March 2019Source: Brain, Behavior, and ImmunityAuthor(s): Pini Matzner, Liat Sorski, Rita Haldar, Lee Shaashua, Amit Benbenishty, Hagar Lavon, Yosi Azan, Elad Sandbank, Rivka Melamed, Ella Rosenne, Shamgar Ben-EliyahuAbstractThe perioperative period holds disproportionate impact on long-term cancer outcomes. Nevertheless, perioperative interventions to improve long-term cancer outcomes are not clinical routines, including perioperative stress-reducing or immune-stimulating approaches. Here, mimicking the clinical setting of pre-operative distress, followed by surgery, we examined the se...
Source: Brain, Behavior, and Immunity - March 7, 2019 Category: Neurology Source Type: research

Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors.
In this study, we investigated whether GT could ameliorate the neurological impairment and striatal toxicity in cellular or animal model of HD. Pre-, co-, and onset-treatment with GT (25, 50, or 100 mg/kg/day, p.o.) alleviated the severity of neurological impairment and lethality following 3-nitropropionic acid (3-NPA). Pretreatment with GT also attenuated mitochondrial dysfunction i.e. succinate dehydrogenase and MitoSOX activities, apoptosis, microglial activation, and mRNA expression of inflammatory mediators i.e. IL-1β, IL-6, TNF-α, COX-2, and iNOS in the striatum after 3-NPA-intoxication. Its action mechani...
Source: Brain, Behavior, and Immunity - March 7, 2019 Category: Neurology Authors: Jang M, Choi JH, Chang Y, Lee SJ, Nah SY, Cho IH Tags: Brain Behav Immun Source Type: research

Depressive Symptoms and Immune Transcriptional Profiles in Late Adolescents.
Abstract BACKGROUND: Rates of depression increase and peak during late adolescence and alterations in immune processes are thought to be both a risk factor and outcome of depression. However, few studies have examined depression-immune dynamics among adolescents. Using a functional genomics approach, the current study examined whether depressive symptoms were associated with activation with a gene expression profile, characterized by upregulated expression of pro-inflammatory-related genes and downregulated expression of antiviral-related genes in a sample of older adolescents (Mage = 18.37, SD = .51). METHOD...
Source: Brain, Behavior, and Immunity - March 6, 2019 Category: Neurology Authors: Chiang JJ, Cole SW, Bower JE, Irwin MR, Taylor SE, Arevalo J, Fuligni AJ Tags: Brain Behav Immun Source Type: research

Deleterious synergistic effects of distress and surgery on cancer metastasis: Abolishment through an integrated perioperative immune-stimulating stress-inflammatory-reducing intervention.
Abstract The perioperative period holds disproportionate impact on long-term cancer outcomes. Nevertheless, perioperative interventions to improve long-term cancer outcomes are not clinical routines, including perioperative stress-reducing or immune-stimulating approaches. Here, mimicking the clinical setting of pre-operative distress, followed by surgery, we examined the separate and combined effects of these events on the efficacy of pre-operative immune stimulation in rats and mice, and on post-operative resistance to tumor metastasis of the syngeneic mammary adenocarcinoma MADB106 in F344 rats and the CT26 col...
Source: Brain, Behavior, and Immunity - March 6, 2019 Category: Neurology Authors: Matzner P, Sorski L, Haldar R, Shaashua L, Benbenishty A, Lavon H, Azan Y, Sandbank E, Melamed R, Rosenne E, Ben-Eliyahu S Tags: Brain Behav Immun Source Type: research

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Abstract A disintegrin and metalloproteinase 17 (ADAM17) is the major sheddase involved in the cleavage of a plethora of cytokines, cytokine receptors and growth factors, thereby playing a substantial role in inflammatory and regenerative processes after central nervous system trauma. By making use of a hypomorphic ADAM17 knockin mouse model as well as pharmacological ADAM10/ADAM17 inhibitors, we showed that ADAM17-deficiency or inhibition significantly increases clearance of apoptotic cells, promotes axon growth and improves functional recovery after spinal cord injury (SCI) in mice. Microglia-specific ADAM17-kno...
Source: Brain, Behavior, and Immunity - March 6, 2019 Category: Neurology Authors: Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Broeckhoven JV, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S Tags: Brain Behav Immun Source Type: research

Sex similarities in the immune response to social stress.
PMID: 30851379 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 6, 2019 Category: Neurology Authors: Hodes GE Tags: Brain Behav Immun Source Type: research

Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety.
CONCLUSION: RMT treatment is able to restore phase-shifted melatonin markers, normalized the altered expression of the circadian genes, the levels of inflammatory cytokines and neurotrophins in patients with insomnia comorbid anxiety and depression. PMID: 30851380 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 6, 2019 Category: Neurology Authors: Kumaran Satyanarayanan S, Chien YC, Pei-Chen Chang J, Huang SY, Guu TW, Su H, Su KP Tags: Brain Behav Immun Source Type: research

Editorial Board
Publication date: March 2019Source: Brain, Behavior, and Immunity, Volume 77Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 1, 2019 Category: Neurology Source Type: research

PNIRS Society Announcements
Publication date: March 2019Source: Brain, Behavior, and Immunity, Volume 77Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 1, 2019 Category: Neurology Source Type: research

Longitudinal changes of inflammatory biomarkers moderate the relationship between recent stressful life events and prospective symptoms of depression in a diverse sample of urban adolescents
In conclusion, adolescents who experienced both recent stressful life events and larger increases in inflammatory activity following these stressors were at increased risk for more severe depressive symptoms after approximately one year. The findings indicate that the interaction of stress and larger changes in inflammatory activity following these stressors are prognostic risk factors for depression severity in adolescents. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 27, 2019 Category: Neurology Source Type: research

Choroid plexus transcriptome and ultrastructure analysis reveals a TLR2-specific chemotaxis signature and cytoskeleton remodeling in leukocyte trafficking
Publication date: Available online 26 February 2019Source: Brain, Behavior, and ImmunityAuthor(s): Amin Mottahedin, C. Joakim Ek, Katarina Truvé, Henrik Hagberg, Carina MallardAbstractPerinatal infection and inflammation are major risk factors for injury in the developing brain, however, underlying mechanisms are not fully understood. Leukocyte migration to the cerebrospinal fluid (CSF) and brain is a hallmark of many pathologies of the central nervous system including those in neonates. We previously reported that systemic activation of Toll-like receptor (TLR) 2, a major receptor for gram-positive bacteria, by ago...
Source: Brain, Behavior, and Immunity - February 27, 2019 Category: Neurology Source Type: research

The Costs of High Self-Control in Black and Latino Youth with Asthma: Divergence of Mental Health and Inflammatory Profiles
This study tested the skin-deep resilience hypothesis in asthma– whether minority youth who are striving hard to succeed academically experience good psychological outcomes but poor asthma outcomes. Youth physician-diagnosed with asthma (N=276, M age=12.99; 155=White, 121=Black/Latino) completed interviews about school stress and a self-control questionnaire. Outcomes included mental health (anxiety/depression) and ex-vivo immunologic processes relevant to asthma (lymphocyte Th-1 and Th-2 cytokine production, and sensitivity to glucocorticoid inhibition). Physician contacts were tracked over a one-year follow-up. For...
Source: Brain, Behavior, and Immunity - February 26, 2019 Category: Neurology Source Type: research

Neuropsychiatric consequences of Childhood Group A Streptococcal infection: a systematic review of preclinical models
Publication date: Available online 25 February 2019Source: Brain, Behavior, and ImmunityAuthor(s): Santiago Mora, Elena Martín-González, Pilar Flores, Margarita MorenoAbstractIn recent years, clinical studies have shown strong epidemiological evidence of an increased risk of developing neuropsychiatric disorders after childhood exposure to streptococcal infection, including the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection (PANDAS). New preclinical studies on Group A streptococcus (GAS) exposure investigate how to disentangle the influences of immune activation to ind...
Source: Brain, Behavior, and Immunity - February 26, 2019 Category: Neurology Source Type: research

Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors
Publication date: Available online 25 February 2019Source: Brain, Behavior, and ImmunityAuthor(s): Ryo Okubo, Takayuki Kinoshita, Noriko Katsumata, Yasuhito Uezono, Jinzhong Xiao, Yutaka J. MatsuokaAbstractBackgroundDysfunctional processing of fear memory may be involved in the pathophysiology of fear of cancer recurrence (FCR), which is cited as the major unmet psychological need of cancer survivors. Emerging evidence has shown that the microbiota-gut-brain (MGB) axis affects depressive and anxiety disorders, and chemotherapy-associated psychological distress. We therefore hypothesized that the gut microbiota is associate...
Source: Brain, Behavior, and Immunity - February 26, 2019 Category: Neurology Source Type: research

Longitudinal changes of inflammatory biomarkers moderate the relationship between recent stressful life events and prospective symptoms of depression in a diverse sample of urban adolescents.
In conclusion, adolescents who experienced both recent stressful life events and larger increases in inflammatory activity following these stressors were at increased risk for more severe depressive symptoms after approximately one year. The findings indicate that the interaction of stress and larger changes in inflammatory activity following these stressors are prognostic risk factors for depression severity in adolescents. PMID: 30822466 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 26, 2019 Category: Neurology Authors: Kautz MM, Coe CL, Anne McArthur B, Mac Giollabhui N, Ellman LM, Abramson LY, Alloy LB Tags: Brain Behav Immun Source Type: research

Choroid plexus transcriptome and ultrastructure analysis reveals a TLR2-specific chemotaxis signature and cytoskeleton remodeling in leukocyte trafficking.
ard C Abstract Perinatal infection and inflammation are major risk factors for injury in the developing brain, however, underlying mechanisms are not fully understood. Leukocyte migration to the cerebrospinal fluid (CSF) and brain is a hallmark of many pathologies of the central nervous system including those in neonates. We previously reported that systemic activation of Toll-like receptor (TLR) 2, a major receptor for gram-positive bacteria, by agonist Pam3CSK4 (P3C) resulted in dramatic neutrophil and monocyte infiltration to the CSF and periventricular brain of neonatal mice, an effect that was absent by the T...
Source: Brain, Behavior, and Immunity - February 26, 2019 Category: Neurology Authors: Mottahedin A, Joakim Ek C, Truvé K, Hagberg H, Mallard C Tags: Brain Behav Immun Source Type: research

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice
Publication date: Available online 23 February 2019Source: Brain, Behavior, and ImmunityAuthor(s): Shiraz Tyebji, Simona Seizova, Alexandra L Garnham, Anthony J Hannan, Christopher J TonkinAbstractToxoplasma gondii (T. gondii) is a neurotropic parasite that is associated with various neuropsychiatric disorders. Rodents infected with T. gondii display a plethora of behavioural alterations, and Toxoplasma infection in humans has been strongly associated with disorders such as schizophrenia, in which impaired social behaviour is an important feature. Elucidating changes at the cellular level relevant to neuropsychiatric condi...
Source: Brain, Behavior, and Immunity - February 25, 2019 Category: Neurology Source Type: research

Stressful life events, inflammation and emotional and behavioural problems in children: A population-based study
Conclusion: Our findings suggest a pathway that may connect early psychosocial adversity and childhood internalising symptoms via higher plasma levels of inflammatory markers such as IL-6. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 25, 2019 Category: Neurology Source Type: research

Inhibition of NOX2 signaling limits pain-related behavior and improves motor function in male mice after spinal cord injury: participation of IL-10/miR-155 pathways
Publication date: Available online 23 February 2019Source: Brain, Behavior, and ImmunityAuthor(s): Boris Sabirzhanov, Yun Li, Marino Coll-Miro, Jessica J. Matyas, Junyun He, Alok Kumar, Nicole Ward, Jingwen Yu, Alan I. Faden, Junfang WuAbstractNADPH oxidase (NOX2) is an enzyme that induces reactive oxygen species (ROS) and serves as a switch between the pro-inflammatory and neurorestorative microglial/macrophage phenotypes; such changes play an important role in neuropathic pain and motor dysfunction. Increased NOX2 expression after spinal cord injury (SCI) has been reported, and inhibition of NOX2 improves motor function....
Source: Brain, Behavior, and Immunity - February 25, 2019 Category: Neurology Source Type: research

Impact of 5 Fluorouracil Chemotherapy on Gut Inflammation, Functional Parameters, and Gut Microbiota
Publication date: Available online 23 February 2019Source: Brain, Behavior, and ImmunityAuthor(s): A.T. Sougiannis, B.N. VanderVeen, R.T. Enos, K.T. Velazquez, J.E. Bader, M. Carson, I. Chatzistamou, M. Walla, M.M. Pena, J.L. Kubinak, M. Nagarkatti, J.A. Carson, E.A. MurphyAbstractEmerging evidence suggests that gut microbiota may influence the response to chemotherapy. We sought to characterize the effects of 5 fluorouracil (5FU) chemotherapy on colon inflammation and functional measures in colorectal cancer (CRC) and to further determine whether gut microbiota can influence this response. 50 C57BL/6 were randomized into ...
Source: Brain, Behavior, and Immunity - February 25, 2019 Category: Neurology Source Type: research