Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells
ConclusionsThe higher abundance of memory T helper cells points towards premature aging of the immune system in MDD patients, even during young adulthood. Patients at high risk for suicide show the clearest immune abnormalities and may represent a clinically relevant subtype of depression. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 14, 2020 Category: Neurology Source Type: research

Differing salivary microbiome diversity, community and diurnal rhythmicity in association with affective state and peripheral inflammation in adults
Publication date: Available online 14 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jordan N. Kohn, Tomasz Kosciolek, Clarisse Marotz, Gajender Aleti, Robert N. Guay-Ross, Seong-Hun Hong, Shalisa Hansen, Austin Swafford, Rob Knight, Suzi Hong (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 14, 2020 Category: Neurology Source Type: research

Sex differences in T cell immune responses, gut permeability and outcome after ischemic stroke in aged mice
This study examined sex differences in central and peripheral T cell immune responses, systemic effects on gut permeability and microbiota diversity and behavioral outcomes after stroke in aged mice. We hypothesized that there are sex differences in the immune response to stroke in aged animals.MethodsC57BL/6N mice (20-22 months) were subjected to 60 min middle cerebral artery occlusion, or sham surgery. T cells were quantified in brain and blood at 3, 7 and 15 days (d) post-stroke by flow cytometry. Peripheral effects on gut permeability and microbiota diversity, as well as neurological function were assessed up to 14d, a...
Source: Brain, Behavior, and Immunity - February 12, 2020 Category: Neurology Source Type: research

Editorial Board
Publication date: February 2020Source: Brain, Behavior, and Immunity, Volume 84Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 6, 2020 Category: Neurology Source Type: research

PNIRS Society Announcements
Publication date: February 2020Source: Brain, Behavior, and Immunity, Volume 84Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 6, 2020 Category: Neurology Source Type: research

N-methyl-D-aspartate Receptor Subunit 2B on Keratinocyte Mediates Peripheral and Central Sensitization in Chronic Post-ischemic Pain in Male Rats
Publication date: Available online 4 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): Xiaohan Xu, Xin Tao, Ping Huang, Feng Lin, Qing Liu, Li Xu, Jijun Xu, Yuguang HuangAbstractThe spinal N-methyl-D-aspartate (NMDA) receptor, and particularly its NR2B subunit, plays a pivotal role in neuropathic pain. However, the role of peripheral NMDA receptor in neuropathic pain is less well understood. We first treated cultured human keratinocytes, HaCaT cells with NMDA or NR2B-specific antagonist, ifenprodil and evaluated the level of total and phosphorylated NR2B at 24h using Western blot. Next, using the chronic post-is...
Source: Brain, Behavior, and Immunity - February 5, 2020 Category: Neurology Source Type: research

Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis
Publication date: Available online 4 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng, Zili YouAbstractMaternal sleep disturbance in pregnancy causes cognitive impairments and emotional disorders in offspring. Microglia-mediated inflammatory processes contribute to prenatal stress-induced neurodevelopmental deficits. Peroxisome proliferator-activated receptor gamma (PPARγ) activation underlies the switching of microglial activation phenotypes, which has emerged as a pharmacological target ...
Source: Brain, Behavior, and Immunity - February 5, 2020 Category: Neurology Source Type: research

Prenatal and childhood adversity and inflammation in children: A population-based longitudinal study
ConclusionIndependently of prenatal adverse life events, the number and increase in number of adverse life events experienced in childhood were associated positively with plasma levels of inflammatory markers, such as IL-6, in girls. This gender specificity warrants further research. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 5, 2020 Category: Neurology Source Type: research

In-vivo imaging of neuroinflammation in Veterans with Gulf War Illness
Publication date: Available online 4 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): Zeynab Alshelh, Daniel S. Albrecht, Courtney Bergan, Oluwaseun Akeju, Daniel J. Clauw, Lisa Conboy, Robert R. Edwards, Minhae Kim, Yvonne C. Lee, Ekaterina Protsenko, Vitaly Napadow, Kimberly Sullivan, Marco L. LoggiaAbstractGulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the veterans who served in the 1991 Gulf War. It is characterised by a constellation of symptoms including musculoskeletal pain, cognitive problems and fatigue. The cause of GWI is not definitively known but exposure to neurotoxica...
Source: Brain, Behavior, and Immunity - February 5, 2020 Category: Neurology Source Type: research

N-methyl-D-aspartate Receptor Subunit 2B on Keratinocyte Mediates Peripheral and Central Sensitization in Chronic Post-ischemic Pain in Male Rats.
Abstract The spinal N-methyl-D-aspartate (NMDA) receptor, and particularly its NR2B subunit, plays a pivotal role in neuropathic pain. However, the role of peripheral NMDA receptor in neuropathic pain is less well understood. We first treated cultured human keratinocytes, HaCaT cells with NMDA or NR2B-specific antagonist, ifenprodil and evaluated the level of total and phosphorylated NR2B at 24h using Western blot. Next, using the chronic post-ischemia pain (CPIP) model, we administered NMDA or ifenprodil subcutaneously into the hind paws of male rats. Nociceptive behaviors were assessed by measuring mechanical an...
Source: Brain, Behavior, and Immunity - February 4, 2020 Category: Neurology Authors: Xu X, Tao X, Huang P, Lin F, Liu Q, Xu L, Xu J, Huang Y Tags: Brain Behav Immun Source Type: research

Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis.
Abstract Maternal sleep disturbance in pregnancy causes cognitive impairments and emotional disorders in offspring. Microglia-mediated inflammatory processes contribute to prenatal stress-induced neurodevelopmental deficits. Peroxisome proliferator-activated receptor gamma (PPARγ) activation underlies the switching of microglial activation phenotypes, which has emerged as a pharmacological target for regulating neuroinflammatory responses in the treatment of neuropsychiatric disorders. Here we investigated the effects of PPARγ-dependent microglial activation on neurogenesis and cognitive behavioral out...
Source: Brain, Behavior, and Immunity - February 4, 2020 Category: Neurology Authors: Han Y, Wang J, Zhao Q, Xie X, Song R, Xiao Y, Kang X, Zhang L, Zhang Y, Peng C, You Z Tags: Brain Behav Immun Source Type: research

Prenatal and childhood adversity and inflammation in children: A population-based longitudinal study.
CONCLUSION: Independently of prenatal adverse life events, the number and increase in number of adverse life events experienced in childhood were associated positively with plasma levels of inflammatory markers, such as IL-6, in girls. This gender specificity warrants further research. PMID: 32027959 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 3, 2020 Category: Neurology Authors: Flouri E, Francesconi M, Midouhas E, Papachristou E, Lewis G Tags: Brain Behav Immun Source Type: research

In-vivo imaging of neuroinflammation in Veterans with Gulf War Illness.
Abstract Gulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the veterans who served in the 1991 Gulf War. It is characterised by a constellation of symptoms including musculoskeletal pain, cognitive problems and fatigue. The cause of GWI is not definitively known but exposure to neurotoxicants, the prophylactic use of pyridostigmine bromide (PB) pills, and/or stressors during deployment have all been suspected to play some pathogenic role. Recent animal models of GWI have suggested neuroinflammatory mechanisms may be implicated, including a dysregulated activation of microglia and astrocyt...
Source: Brain, Behavior, and Immunity - February 3, 2020 Category: Neurology Authors: Alshelh Z, Albrecht DS, Bergan C, Akeju O, Clauw DJ, Conboy L, Edwards RR, Kim M, Lee YC, Protsenko E, Napadow V, Sullivan K, Loggia ML Tags: Brain Behav Immun Source Type: research

To exclude or not to exclude: considerations and recommendations for C-Reactive Protein values higher than 10 mg/L
Publication date: Available online 31 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Naoise Mac Giollabhui, Lauren M. Ellman, Christopher L. Coe, Michelle L. Byrne, Lyn Y. Abramson, Lauren B. AlloyAbstractThis research was supported by National Institute of Mental Health Grants MH079369 and MH101168 awarded to Lauren Alloy, National Institute of Mental Health Grant MH096478 awarded to Lauren Ellman and National Research Service Awards F31MH118808 to Naoise Mac Giollabhui. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 2, 2020 Category: Neurology Source Type: research

Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway
Publication date: Available online 31 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Zhanyang Qian, Jie Chang, Fan Jiang, Dawei Ge, Lei Yang, You Li, Hongtao Chen, Xiaojian CaoAbstractSpinal cord injury (SCI) is a destructive polyneuropathy that can result in loss of sensorimotor function and sphincter dysfunction, and even death in critical situations. MicroRNAs (miRs) are a series of non-coding RNA molecules that are involved in transcriptional regulation. Previous studies have demonstrated that modulation of multiple miRs is involved in neurological recovery after SCI. However, the functions of miR-340-5p i...
Source: Brain, Behavior, and Immunity - February 2, 2020 Category: Neurology Source Type: research

let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model
Publication date: Available online 1 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): David L. Bernstein, Sachin Gajghate, Nancy L. Reichenbach, Malika Winfield, Yuri Persidsky, Nathan A. Heldt, Slava RomAbstractStroke is a debilitating disease, accounting for almost 20% of all hospital visits, and 8% of all fatalities in the United States in 2017. Following an ischemic attack, inflammatory processes originating from endothelial cells within the brain microvasculature can induce many toxic effects into the impacted area, from both sides of the blood brain barrier (BBB). In addition to increased BBB permeability...
Source: Brain, Behavior, and Immunity - February 2, 2020 Category: Neurology Source Type: research

let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model.
Abstract Stroke is a debilitating disease, accounting for almost 20% of all hospital visits, and 8% of all fatalities in the United States in 2017. Following an ischemic attack, inflammatory processes originating from endothelial cells within the brain microvasculature can induce many toxic effects into the impacted area, from both sides of the blood brain barrier (BBB). In addition to increased BBB permeability, impacted brain microvascular endothelial cells can recruit macrophages and other immune cells from the periphery and can also trigger the activation of microglia and astrocytes within the brain. We have i...
Source: Brain, Behavior, and Immunity - February 1, 2020 Category: Neurology Authors: Bernstein DL, Gajghate S, Reichenbach NL, Winfield M, Persidsky Y, Heldt NA, Rom S Tags: Brain Behav Immun Source Type: research

Dialing in the Dialogue Between Inflammation and the Brain
Publication date: Available online 31 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Keith W. Kelley, Annabelle Réaux-Le GoazigoAbstractThe nervous and immune systems communicate with one another and jointly influence functional responses. To highlight the many advances on this hot topic, Brain, Behavior, and Immunity conceptualized a Special Issue entitled “Dialing in the Dialogue Between Inflammation and the Brain.” Recent advances and exciting developments in understanding communication pathways between the brain and the immune system during both physiological and pathological insults are...
Source: Brain, Behavior, and Immunity - January 31, 2020 Category: Neurology Source Type: research

Behavioural and histological changes in cuprizone-fed mice
This study investigated whether 37 days oral feeding of 0.2% CPZ to young adult mice evoked sensorimotor behavioural changes. Behavioural tests included measurements of nociceptive withdrawal reflex responses and locomotor tests. Additionally, these were compared to histological analysis of the relevant CNS regions by analysis of neuronal and glial cell components. CPZ-fed mice exhibited more foot slips in walking ladder and beam tests compared to controls. In contrast, no changes in nociceptive thresholds to thermal or mechanical stimuli occurred between groups. Histological analysis showed demyelination throughout the CN...
Source: Brain, Behavior, and Immunity - January 31, 2020 Category: Neurology Source Type: research

Dialing in the Dialogue Between Inflammation and the Brain.
Abstract The nervous and immune systems communicate with one another and jointly influence functional responses. To highlight the many advances on this hot topic, Brain, Behavior, and Immunity conceptualized a Special Issue entitled "Dialing in the Dialogue Between Inflammation and the Brain." Recent advances and exciting developments in understanding communication pathways between the brain and the immune system during both physiological and pathological insults are highlighted. PMID: 32014576 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 31, 2020 Category: Neurology Authors: Kelley KW, Goazigo AR Tags: Brain Behav Immun Source Type: research

Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway.
Abstract Spinal cord injury (SCI) is a destructive polyneuropathy that can result in loss of sensorimotor function and sphincter dysfunction, and even death in critical situations. MicroRNAs (miRs) are a series of non-coding RNA molecules that are involved in transcriptional regulation. Previous studies have demonstrated that modulation of multiple miRs is involved in neurological recovery after SCI. However, the functions of miR-340-5p in SCI remain uncertain. Therefore, we probed the therapeutic effect and mechanism of miR-340-5p in microglia in vitro and in vivo in SCI rats. Reverse transcription-quantitative p...
Source: Brain, Behavior, and Immunity - January 31, 2020 Category: Neurology Authors: Qian Z, Chang J, Jiang F, Ge D, Yang L, Li Y, Chen H, Cao X Tags: Brain Behav Immun Source Type: research

Behavioural and histological changes in cuprizone-fed mice.
This study investigated whether 37 days oral feeding of 0.2% CPZ to young adult mice evoked sensorimotor behavioural changes. Behavioural tests included measurements of nociceptive withdrawal reflex responses and locomotor tests. Additionally, these were compared to histological analysis of the relevant CNS regions by analysis of neuronal and glial cell components. CPZ-fed mice exhibited more foot slips in walking ladder and beam tests compared to controls. In contrast, no changes in nociceptive thresholds to thermal or mechanical stimuli occurred between groups. Histological analysis showed demyelination throughout the CN...
Source: Brain, Behavior, and Immunity - January 31, 2020 Category: Neurology Authors: Sen MK, Almuslehi MSM, Coorssen JR, Mahns DA, Shortland PJ Tags: Brain Behav Immun Source Type: research

To exclude or not to exclude: considerations and recommendations for C-Reactive Protein values higher than 10 mg/L.
Abstract This research was supported by National Institute of Mental Health Grants MH079369 and MH101168 awarded to Lauren Alloy, National Institute of Mental Health Grant MH096478 awarded to Lauren Ellman and National Research Service Awards F31MH118808 to Naoise Mac Giollabhui. PMID: 32014579 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 31, 2020 Category: Neurology Authors: Mac Giollabhui N, Ellman LM, Coe CL, Byrne ML, Abramson LY, Alloy LB Tags: Brain Behav Immun Source Type: research

Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease
We examined changes in peripheral innate immune-related markers in PD cases (n=41) stratified according to risk of developing early dementia. ‘Higher Risk’(HR) (n=23) and ‘Lower Risk’ (LR) (n=18) groups were defined according to neuropsychological predictors and MAPT H1/H2 genotype, and compared to age, gender and genotype-matched controls. Monocyte subsets and expression of key surface markers were measured using flow cytometry. Serum markers including alpha-synuclein, inflammasome-related caspase-1 and bacterial translocation-related endotoxin were measured using quantitative immuno-based assays. ...
Source: Brain, Behavior, and Immunity - January 30, 2020 Category: Neurology Source Type: research

Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats
In conclusion, zinc treatment was beneficial for sickness behavior and depressive-like behavior without concomitant administration of antidepressants. IFN-gamma and GFAP were linked with the expression of sickness behavior and depressive-like behavior and were also involved with the antidepressant effects. Therefore, zinc, IFN-gamma, and GFAP pathways should be considered for depression treatment. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 30, 2020 Category: Neurology Source Type: research

Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats.
In conclusion, zinc treatment was beneficial for sickness behavior and depressive-like behavior without concomitant administration of antidepressants. IFN-gamma and GFAP were linked with the expression of sickness behavior and depressive-like behavior and were also involved with the antidepressant effects. Therefore, zinc, IFN-gamma, and GFAP pathways should be considered for depression treatment. PMID: 32006614 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 29, 2020 Category: Neurology Authors: Kirsten TB, Cabral D, Galvão MC, Monteiro R, Bondan EF, Martha Bernardi M Tags: Brain Behav Immun Source Type: research

Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.
We examined changes in peripheral innate immune-related markers in PD cases (n=41) stratified according to risk of developing early dementia. 'Higher Risk'(HR) (n=23) and 'Lower Risk' (LR) (n=18) groups were defined according to neuropsychological predictors and MAPT H1/H2 genotype, and compared to age, gender and genotype-matched controls. Monocyte subsets and expression of key surface markers were measured using flow cytometry. Serum markers including alpha-synuclein, inflammasome-related caspase-1 and bacterial translocation-related endotoxin were measured using quantitative immuno-based assays. Specific markers were fu...
Source: Brain, Behavior, and Immunity - January 29, 2020 Category: Neurology Authors: Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, Breen DP, Cummins G, Jones JL, Clatworthy MR, Andres Floto R, Barker RA, Williams-Gray CH Tags: Brain Behav Immun Source Type: research

Resveratrol alleviates temporomandibular joint inflammatory pain by recovering disturbed gut microbiota
Publication date: Available online 27 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Yajing Ma, Sufang Liu, Hui Shu, Joshua Crawford, Ying Xing, Feng TaoAbstractPatients with temporomandibular disorders (TMDs) often experience persistent facial pain. However, the treatment of TMD pain is still inadequate. In recent years, the disturbance of gut microbiota has been shown to play an important role in the pathogenesis of different neurological diseases including chronic pain. In the present study, we investigated the involvement of gut microbiota in the development of temporomandibular joint (TMJ) inflammation. I...
Source: Brain, Behavior, and Immunity - January 28, 2020 Category: Neurology Source Type: research

Blood-borne and brain-derived microparticles in morphine-induced anti-nociceptive tolerance
Publication date: Available online 27 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Deepa Ruhela, Veena M. Bhopale, Ming Yang, Kevin Yu, Eric Weintraub, Aaron Greenblatt, Stephen R. ThomAbstractWe hypothesized that elevations of microparticles (MPs) would occur with morphine administration to mice. Repetitive dosing to induce anti-nociceptive tolerance increases blood-borne MPs by 8-fold, and by 10-fold in deep cervical lymph nodes draining brain glymphatics. MPs express proteins specific to cells including neutrophils, microglia, astrocytes, neurons and oligodendrocytes. Interleukin (IL)-1β content of M...
Source: Brain, Behavior, and Immunity - January 27, 2020 Category: Neurology Source Type: research

Resveratrol alleviates temporomandibular joint inflammatory pain by recovering disturbed gut microbiota.
Abstract Patients with temporomandibular disorders (TMDs) often experience persistent facial pain. However, the treatment of TMD pain is still inadequate. In recent years, the disturbance of gut microbiota has been shown to play an important role in the pathogenesis of different neurological diseases including chronic pain. In the present study, we investigated the involvement of gut microbiota in the development of temporomandibular joint (TMJ) inflammation. Intra-temporomandibular joint injection of complete Freund's adjuvant (CFA) was employed to induce TMJ inflammation. Resveratrol (RSV), a natural bioactive c...
Source: Brain, Behavior, and Immunity - January 27, 2020 Category: Neurology Authors: Ma Y, Liu S, Shu H, Crawford J, Xing Y, Tao F Tags: Brain Behav Immun Source Type: research

Blood-borne and brain-derived microparticles in morphine-induced anti-nociceptive tolerance.
Abstract We hypothesized that elevations of microparticles (MPs) would occur with morphine administration to mice. Repetitive dosing to induce anti-nociceptive tolerance increases blood-borne MPs by 8-fold, and by 10-fold in deep cervical lymph nodes draining brain glymphatics. MPs express proteins specific to cells including neutrophils, microglia, astrocytes, neurons and oligodendrocytes. Interleukin (IL)-1β content of MPs increases 68-fold. IL-1β antagonist administration diminishes blood-borne and cervical lymph node MPs, and abrogates tolerance induction. Intravenous polyethylene glycol Telomer B, a...
Source: Brain, Behavior, and Immunity - January 27, 2020 Category: Neurology Authors: Ruhela D, Bhopale VM, Yang M, Yu K, Weintraub E, Greenblatt A, Thom SR Tags: Brain Behav Immun Source Type: research

Depressive-like phenotype evoked by lifelong nutritional omega-3 deficiency in female rats: crosstalk among kynurenine, Toll-like receptors and amyloid beta oligomers
Publication date: Available online 24 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Maria Grazia Morgese, Stefania Schiavone, Angela Bruna Maffione, Paolo Tucci, Luigia TrabaceAbstractDepression is one of the most common psychiatric diseases and the prevalence of depressive symptoms in women is almost twice compared to men, although the reasons of this gender difference are not fully understood yet. Recently, soluble amyloid beta (Aβ)1-42 peptide has been receiving great importance in the development of depression, also considering that depression is highly comorbid with Alzheimer’s disease and oth...
Source: Brain, Behavior, and Immunity - January 25, 2020 Category: Neurology Source Type: research

Baseline high levels of complement component 4 predict worse clinical outcome at 1-year follow-up in first-episode psychosis
ConclusionsOur preliminary findings show that baseline C4 levels predict clinical outcome at 1-year follow-up in patients with first episode psychosis. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 24, 2020 Category: Neurology Source Type: research

A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice
In this study, methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal neurodegeneration and astro-glial activations were determined by western blot and immunofluorescence techniques in wild type (WT) mice, MC-deficient (MC-KO) mice and GMF-deficient (GMF-KO) mice, with or without MC reconstitution before MPTP administration. We show that GMF-KO in the MCs reduces the synergistic effects of MC and Calpain1 (calcium-activated cysteine protease enzyme)-dependent dopaminergic neuronal loss that reduces motor behavioral impairments in MPTP-treated mouse. Administration of MPTP increase in calpain-mediated prote...
Source: Brain, Behavior, and Immunity - January 24, 2020 Category: Neurology Source Type: research

Depressive-like phenotype evoked by lifelong nutritional omega-3 deficiency in female rats: crosstalk among kynurenine, Toll-like receptors and amyloid beta oligomers.
Abstract Depression is one of the most common psychiatric diseases and the prevalence of depressive symptoms in women is almost twice compared to men, although the reasons of this gender difference are not fully understood yet. Recently, soluble amyloid beta (Aβ)1-42 peptide has been receiving great importance in the development of depression, also considering that depression is highly comorbid with Alzheimer's disease and other neurodegenerative illnesses. The central role played by Aβ in the development of depressive-like symptoms in rodents has been evidenced in environmental rodent model of depressio...
Source: Brain, Behavior, and Immunity - January 24, 2020 Category: Neurology Authors: Grazia Morgese M, Schiavone S, Bruna Maffione A, Tucci P, Trabace L Tags: Brain Behav Immun Source Type: research

A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice.
In this study, methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal neurodegeneration and astro-glial activations were determined by western blot and immunofluorescence techniques in wild type (WT) mice, MC-deficient (MC-KO) mice and GMF-deficient (GMF-KO) mice, with or without MC reconstitution before MPTP administration. We show that GMF-KO in the MCs reduces the synergistic effects of MC and Calpain1 (calcium-activated cysteine protease enzyme)-dependent dopaminergic neuronal loss that reduces motor behavioral impairments in MPTP-treated mouse. Administration of MPTP increase in calpain-mediated prote...
Source: Brain, Behavior, and Immunity - January 23, 2020 Category: Neurology Authors: Pushpavathi Selvakumar G, Ejaz Ahmed M, Thangavel R, Kempuraj D, Dubova I, Raikwar SP, Zaheer S, Iyer SS, Zaheer A Tags: Brain Behav Immun Source Type: research

Corrigendum to “Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture” [Brain Behav. Immun. 83 (2020) 270–282]
Publication date: Available online 21 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Zhenyu Yin, Zhaoli Han, Tianpeng Hu, Shishuang Zhang, Xintong Ge, Shan Huang, Lu Wang, Jinwen Yu, Wenzhu Li, Yan Wang, Dai li, Jing Zhao, Yifeng Wang, Yan Zuo, Ying Li, Xiaodong Kong, Fanglian Chen, Ping Lei (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 22, 2020 Category: Neurology Source Type: research

Baseline high levels of complement component 4 predict worse clinical outcome at 1-year follow-up in first-episode psychosis.
CONCLUSIONS: Our preliminary findings show that baseline C4 levels predict clinical outcome at 1-year follow-up in patients with first episode psychosis. PMID: 31981599 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 22, 2020 Category: Neurology Authors: Mondelli V, Di Forti M, Paul Morgan B, Murray RM, Pariante CM, Dazzan P Tags: Brain Behav Immun Source Type: research

The combined association of depressive symptoms and C-reactive protein for incident disease risk up to 12 years later. Findings from the English Longitudinal of Ageing (ELSA)
ConclusionA combination of depressive symptoms and CRP was implicated in the onset of CHD, stroke, diabetes/high blood glucose, and pulmonary disease up to 12 years later, reflecting the role of psychobiological processes across multiple disease states. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Source Type: research

The Relationship between Plasma Serotonin and Kynurenine Pathway Metabolite Levels and the Treatment Response to Escitalopram and Desvenlafaxine
ConclusionsIn MDD patients the antidepressant response to escitalopram was positively associated with baseline serotonin levels and inversely associated with activation of the kynurenine pathway. These results appear consistent with previous literature showing that biomarker evidence of inflammation is associated with lower response to antidepressants from the selective serotonin reuptake inhibitor class. Moreover, increases in the kynurenic acid (KynA)/3-hydroxykynurenine (3HK) ratio, which previously has been characterized as a neuroprotective index, were associated with full remission under escitalopram treatment. (Sour...
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Source Type: research

Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells
Publication date: Available online 21 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Virginia Mela, Bibiana C. Mota, Mark Milner, Aoife McGinley, Kingston H.G. Mills, Áine M Kelly, Marina A. LynchAbstractMicroglial activation and neuroinflammatory changes are characteristic of the aged brain and contribute to age-related cognitive impairment. Exercise improves cognitive function in aged animals, perhaps because of a modulatory effect on microglial activation. Recent evidence indicates that inflammatory microglia are glycolytic, driven by an increase in 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase...
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Source Type: research

Corrigendum to "Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture" [Brain Behav. Immun. 83 (2020) 270-282].
Corrigendum to "Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture" [Brain Behav. Immun. 83 (2020) 270-282]. Brain Behav Immun. 2020 Jan 21;: Authors: Yin Z, Han Z, Hu T, Zhang S, Ge X, Huang S, Wang L, Yu J, Li W, Wang Y, Li D, Zhao J, Wang Y, Zuo Y, Li Y, Kong X, Chen F, Lei P PMID: 31980298 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Authors: Yin Z, Han Z, Hu T, Zhang S, Ge X, Huang S, Wang L, Yu J, Li W, Wang Y, Li D, Zhao J, Wang Y, Zuo Y, Li Y, Kong X, Chen F, Lei P Tags: Brain Behav Immun Source Type: research

Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells.
ch MA Abstract Microglial activation and neuroinflammatory changes are characteristic of the aged brain and contribute to age-related cognitive impairment. Exercise improves cognitive function in aged animals, perhaps because of a modulatory effect on microglial activation. Recent evidence indicates that inflammatory microglia are glycolytic, driven by an increase in 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), an enzyme that is described as the master regulator of glycolysis. Here we investigated whether microglia from aged animals exhibited a glycolytic signature and whether exercise exerted a...
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Authors: Mela V, Mota BC, Milner M, McGinley A, Mills KHG, Kelly ÁM, Lynch MA Tags: Brain Behav Immun Source Type: research

The Relationship between Plasma Serotonin and Kynurenine Pathway Metabolite Levels and the Treatment Response to Escitalopram and Desvenlafaxine.
CONCLUSIONS: In MDD patients the antidepressant response to escitalopram was positively associated with baseline serotonin levels and inversely associated with activation of the kynurenine pathway. These results appear consistent with previous literature showing that biomarker evidence of inflammation is associated with lower response to antidepressants from the selective serotonin reuptake inhibitor class. Moreover, increases in the kynurenic acid (KynA)/3-hydroxykynurenine (3HK) ratio, which previously has been characterized as a neuroprotective index, were associated with full remission under escitalopram treatment. ...
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Authors: Sun Y, Drevets W, Turecki G, Li QS Tags: Brain Behav Immun Source Type: research

The combined association of depressive symptoms and C-reactive protein for incident disease risk up to 12 years later. Findings from the English Longitudinal of Ageing (ELSA).
CONCLUSION: A combination of depressive symptoms and CRP was implicated in the onset of CHD, stroke, diabetes/high blood glucose, and pulmonary disease up to 12 years later, reflecting the role of psychobiological processes across multiple disease states. PMID: 31972338 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 20, 2020 Category: Neurology Authors: Poole L, Steptoe A Tags: Brain Behav Immun Source Type: research

Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults
ConclusionPeripheral pro-inflammatory signaling in older adults without dementia, especially among APOE ε4-positive individuals, is associated with altered connectivity within two large-scale cognitive networks. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 12, 2020 Category: Neurology Source Type: research

Regulation of Immune-Driven Pathogenesis in Parkinson’s Disease by Gut Microbiota
Publication date: Available online 10 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Wenxia Zheng, Rongni He, Zhenxing Yan, Yaowei Huang, Wei Huang, Zhuoyi Cai, Yuying Su, Siqin Liu, Yiting Deng, Qing Wang, Huifang XieAbstractParkinson’s disease (PD) is one of the most significant medical and social burdens of our time. The prevalence of PD increases with age and the number of individuals diagnosed with PD is expected to double from 6.9 million in 2015 to 14.2 million in 2040. To date, no drugs can stop the ongoing neurodegeneration caused by PD due to its unclear and complex pathogenic mechanisms. It ha...
Source: Brain, Behavior, and Immunity - January 12, 2020 Category: Neurology Source Type: research

Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults.
CONCLUSION: Peripheral pro-inflammatory signaling in older adults without dementia, especially among APOE ε4-positive individuals, is associated with altered connectivity within two large-scale cognitive networks. PMID: 31935468 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 11, 2020 Category: Neurology Authors: Walker KA, Gross AL, Moghekar AR, Soldan A, Pettigrew C, Hou X, Lu H, Alfini AJ, Bilgel M, Miller MI, Albert MS, Walston J Tags: Brain Behav Immun Source Type: research

T-cell Defects and Postpartum Depression
Publication date: Available online 8 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Lauren M. Osborne, Janneke Gilden, Astrid M. Kamperman, Witte.J.G. Hoogendijk, Julie Spicer, Hemmo A. Drexhage, Veerle BerginkAbstractBackgroundMost studies of immune dysregulation in perinatal mood and anxiety disorders have focused on peripheral cytokines, but literature from non-perinatal mood disorders also implicates T-cell defects. We sought to characterize proportions of T-cell subtypes in women with postpartum depression.Materials and MethodsWe enrolled 21 women with postpartum depression (PPD), 39 healthy postpartum co...
Source: Brain, Behavior, and Immunity - January 10, 2020 Category: Neurology Source Type: research

Is inflammation-associated depression atypical depression?
Publication date: Available online 8 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Julie Lasselin (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 10, 2020 Category: Neurology Source Type: research