Metformin, the gut microbiome and neurogenesis: Lessons learned in rebirth of an old drug
Publication date: Available online 16 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Gerard Clarke (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 16, 2021 Category: Neurology Source Type: research

E-vaping and high-fat diet consumption: it’s all a hazy memory
Publication date: Available online 16 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Ross Vlahos (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 16, 2021 Category: Neurology Source Type: research

Editorial Board
Publication date: May 2021Source: Brain, Behavior, and Immunity, Volume 94Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 15, 2021 Category: Neurology Source Type: research

PNIRS Society Announcements
Publication date: May 2021Source: Brain, Behavior, and Immunity, Volume 94Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 15, 2021 Category: Neurology Source Type: research

Long-term coordinated microstructural disruptions of the developing neocortex and subcortical white matter after early postnatal systemic inflammation
Publication date: May 2021Source: Brain, Behavior, and Immunity, Volume 94Author(s): Jaya D. Prasad, Yohan van de Looij, Katherine C. Gunn, Sonya M. Ranchhod, Petra B. White, Mary J. Berry, Laura Bennet, Stéphane V. Sizonenko, Alistair J. Gunn, Justin M. Dean (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 15, 2021 Category: Neurology Source Type: research

Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice
Publication date: May 2021Source: Brain, Behavior, and Immunity, Volume 94Author(s): Eoin O'Neill, Éadaoin W. Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningham (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 15, 2021 Category: Neurology Source Type: research

Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis
In conclusion, the present study indicated that MOS significantly attenuates the cognitive and mental deficits in the 5xFAD mice, which could be partly explained by the reshaped microbiome and enhanced SCFAs formation in the gut. MOS, as a probiotic, can be translated into a novel microbiota-targeted approach for managing metabolic and neurodegenerative diseases.PMID:33839232 | DOI:10.1016/j.bbi.2021.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2021 Category: Neurology Authors: Qing Liu Yujia Xi Qianxu Wang Jinhui Liu Peiran Li Xue Meng Kai Liu Weixuan Chen Xuebo Liu Zhigang Liu Source Type: research

Human in vivo neuroimaging to detect reprogramming of the cerebral immune response following repeated systemic inflammation
This study in healthy volunteers examined the trajectory of the immune response systemically and within the brain following repeated lipopolysaccharide (LPS) challenges. Five young males underwent experimental human endotoxemia (intravenous administration of 2 ng/kg LPS) twice with a 7-day interval. The systemic immune response was assessed by measuring plasma cytokine levels. Four positron emission tomography (PET) examinations, using the translocator protein (TSPO) ligand 18F-DPA-714, were performed in each participant, to assess brain immune cell activation prior to and 5 hours after both LPS challenges. The first LPS c...
Source: Brain, Behavior, and Immunity - April 11, 2021 Category: Neurology Authors: Annemieke M Peters van Ton Guus P Leijte Gerben M Franssen Niklas Bruse Jan Booij Janine Doorduin Mark Rijpkema Matthijs Kox Wilson F Abdo Peter Pickkers Source Type: research

Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis
In conclusion, the present study indicated that MOS significantly attenuates the cognitive and mental deficits in the 5xFAD mice, which could be partly explained by the reshaped microbiome and enhanced SCFAs formation in the gut. MOS, as a probiotic, can be translated into a novel microbiota-targeted approach for managing metabolic and neurodegenerative diseases.PMID:33839232 | DOI:10.1016/j.bbi.2021.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2021 Category: Neurology Authors: Qing Liu Yujia Xi Qianxu Wang Jinhui Liu Peiran Li Xue Meng Kai Liu Weixuan Chen Xuebo Liu Zhigang Liu Source Type: research

Human in vivo neuroimaging to detect reprogramming of the cerebral immune response following repeated systemic inflammation
This study in healthy volunteers examined the trajectory of the immune response systemically and within the brain following repeated lipopolysaccharide (LPS) challenges. Five young males underwent experimental human endotoxemia (intravenous administration of 2 ng/kg LPS) twice with a 7-day interval. The systemic immune response was assessed by measuring plasma cytokine levels. Four positron emission tomography (PET) examinations, using the translocator protein (TSPO) ligand 18F-DPA-714, were performed in each participant, to assess brain immune cell activation prior to and 5 hours after both LPS challenges. The first LPS c...
Source: Brain, Behavior, and Immunity - April 11, 2021 Category: Neurology Authors: Annemieke M Peters van Ton Guus P Leijte Gerben M Franssen Niklas Bruse Jan Booij Janine Doorduin Mark Rijpkema Matthijs Kox Wilson F Abdo Peter Pickkers Source Type: research

Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J. Cerebral ischemia increases bone marrow CD4+ CD25+ FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system. Brain Behav Immun. 2015 Jan; 43:172–83
Publication date: Available online 20 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): Carmine Pariante (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Source Type: research

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder
This study aimed to establish the relationship between peripheral markers of inflammation and brain morphology and determine whether such relationships differed across healthy controls and individuals with first episode psychosis (FEP) and chronic schizophrenia. A panel of 13 pro- and anti-inflammatory cytokines were quantified from serum in 175 participants [n=84 Healthy Controls (HC), n=40 FEP, n=51 Chronic SCZ]. We first performed a series of permutation tests to identify the cytokines most consistently associated with brain structural regions. Using moderation analysis, we then determined the extent to which individual...
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Authors: Liliana Laskaris Sam Mancuso Cynthia Shannon Weickert Andrew Zalesky Gursharan Chana Cassandra Wannan Chad Bousman Bernhard Baune Patrick McGorry Christos Pantelis Vanessa Cropley Source Type: research

Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3-C3R signaling
In this study, astrocytic Kir6.1 knockout (KO) mice were used to examine the effect of astrocytic Kir6.1/K-ATP channel on astrocytic complement activation triggered by the lipopolysaccharide (LPS). Here, we found that astrocytic Kir6.1 KO mice showed more dopaminergic neuron loss and more astrocyte reactivity in substantia nigra compacta than controls. We also found that astrocytic Kir6.1 KO increased the expression of complement C3 in astrocytes in LPS-induced mouse model of PD. Mechanistically, astrocytic Kir6.1 KO promoted astroglial NF-κB activation to elicit extracellular release of C3, which in turn interacted ...
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Authors: Miao-Miao Chen Zhao-Li Hu Jian-Hua Ding Ren-Hong Du Gang Hu Source Type: research

Innate immune memory mediates increased susceptibility to Alzheime ŕs disease-like pathology in sepsis surviving mice
Brain Behav Immun. 2021 Apr 7:S0889-1591(21)00158-6. doi: 10.1016/j.bbi.2021.04.001. Online ahead of print.ABSTRACTSepsis survivors show long-term impairments, including alterations in memory and executive function. Evidence suggests that systemic inflammation contributes to the progression of Alzheimeŕs disease (AD), but the mechanisms involved in this process are still unclear. Boosted (trained) and diminished (tolerant) innate immune memory has been described in peripheral immune cells after sepsis. However, the occurrence of long-term innate immune memory in the post-septic brain is fully unexplored. Here, we demonstr...
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Authors: Virginia L De Sousa Suzana B Ara újo Leticia M Antonio Mariana Silva-Queiroz Lilian C Colodeti Carolina Soares Fernanda Barros-Arag ão Hannah P Mota-Araujo Vin ícius S Alves Robson Coutinho-Silva Luiz Eduardo B Savio Sergio T Ferreira Robson da Costa J Source Type: research

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder
This study aimed to establish the relationship between peripheral markers of inflammation and brain morphology and determine whether such relationships differed across healthy controls and individuals with first episode psychosis (FEP) and chronic schizophrenia. A panel of 13 pro- and anti-inflammatory cytokines were quantified from serum in 175 participants [n=84 Healthy Controls (HC), n=40 FEP, n=51 Chronic SCZ]. We first performed a series of permutation tests to identify the cytokines most consistently associated with brain structural regions. Using moderation analysis, we then determined the extent to which individual...
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Authors: Liliana Laskaris Sam Mancuso Cynthia Shannon Weickert Andrew Zalesky Gursharan Chana Cassandra Wannan Chad Bousman Bernhard Baune Patrick McGorry Christos Pantelis Vanessa Cropley Source Type: research

Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3-C3R signaling
In this study, astrocytic Kir6.1 knockout (KO) mice were used to examine the effect of astrocytic Kir6.1/K-ATP channel on astrocytic complement activation triggered by the lipopolysaccharide (LPS). Here, we found that astrocytic Kir6.1 KO mice showed more dopaminergic neuron loss and more astrocyte reactivity in substantia nigra compacta than controls. We also found that astrocytic Kir6.1 KO increased the expression of complement C3 in astrocytes in LPS-induced mouse model of PD. Mechanistically, astrocytic Kir6.1 KO promoted astroglial NF-κB activation to elicit extracellular release of C3, which in turn interacted ...
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Authors: Miao-Miao Chen Zhao-Li Hu Jian-Hua Ding Ren-Hong Du Gang Hu Source Type: research

Innate immune memory mediates increased susceptibility to Alzheime ŕs disease-like pathology in sepsis surviving mice
Brain Behav Immun. 2021 Apr 7:S0889-1591(21)00158-6. doi: 10.1016/j.bbi.2021.04.001. Online ahead of print.ABSTRACTSepsis survivors show long-term impairments, including alterations in memory and executive function. Evidence suggests that systemic inflammation contributes to the progression of Alzheimeŕs disease (AD), but the mechanisms involved in this process are still unclear. Boosted (trained) and diminished (tolerant) innate immune memory has been described in peripheral immune cells after sepsis. However, the occurrence of long-term innate immune memory in the post-septic brain is fully unexplored. Here, we demonstr...
Source: Brain, Behavior, and Immunity - April 10, 2021 Category: Neurology Authors: Virginia L De Sousa Suzana B Ara újo Leticia M Antonio Mariana Silva-Queiroz Lilian C Colodeti Carolina Soares Fernanda Barros-Arag ão Hannah P Mota-Araujo Vin ícius S Alves Robson Coutinho-Silva Luiz Eduardo B Savio Sergio T Ferreira Robson da Costa J Source Type: research

Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis
Publication date: Available online 9 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Qing Liu, Yujia Xi, Qianxu Wang, Jinhui Liu, Peiran Li, Xue Meng, Kai Liu, Weixuan Chen, Xuebo Liu, Zhigang Liu (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 9, 2021 Category: Neurology Source Type: research

Human in vivo neuroimaging to detect reprogramming of the cerebral immune response following repeated systemic inflammation
Publication date: Available online 9 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Annemieke M. Peters van Ton, Guus P. Leijte, Gerben M. Franssen, Niklas Bruse, Jan Booij, Janine Doorduin, Mark Rijpkema, Matthijs Kox, Wilson F. Abdo, Peter Pickkers (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 9, 2021 Category: Neurology Source Type: research

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder
Publication date: Available online 8 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Liliana Laskaris, Sam Mancuso, Cynthia Shannon Weickert, Andrew Zalesky, Gursharan Chana, Cassandra Wannan, Chad Bousman, Bernhard Baune, Patrick McGorry, Christos Pantelis, Vanessa Cropley (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 8, 2021 Category: Neurology Source Type: research

Innate immune memory mediates increased susceptibility to Alzheimeŕs disease-like pathology in sepsis surviving mice
Publication date: Available online 8 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Virginia L. De Sousa, Suzana B. Araújo, Leticia M. Antonio, Mariana Silva-Queiroz, Lilian C. Colodeti, Carolina Soares, Fernanda Barros-Aragão, Hannah P. Mota-Araujo, Vinícius S. Alves, Robson Coutinho-Silva, Luiz Eduardo B. Savio, Sergio T. Ferreira, Robson da Costa, Julia R. Clarke, Claudia P. Figueiredo (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 8, 2021 Category: Neurology Source Type: research

Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3-C3R signaling
Publication date: Available online 8 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Miao-Miao Chen, Zhao-Li Hu, Jian-Hua Ding, Ren-Hong Du, Gang Hu (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 8, 2021 Category: Neurology Source Type: research

Commentary: Connecting Cytokines to Distress via Cortisol Concentrations
Brain Behav Immun. 2021 Apr 5:S0889-1591(21)00157-4. doi: 10.1016/j.bbi.2021.03.027. Online ahead of print.NO ABSTRACTPMID:33831472 | DOI:10.1016/j.bbi.2021.03.027 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 8, 2021 Category: Neurology Authors: Enzo Cipriani Philippe Kerr Christophe Longpr é-Poirier Nicolas Rohleder Robert-Paul Juster Source Type: research

Commentary: Connecting Cytokines to Distress via Cortisol Concentrations
Brain Behav Immun. 2021 Apr 5:S0889-1591(21)00157-4. doi: 10.1016/j.bbi.2021.03.027. Online ahead of print.NO ABSTRACTPMID:33831472 | DOI:10.1016/j.bbi.2021.03.027 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 8, 2021 Category: Neurology Authors: Enzo Cipriani Philippe Kerr Christophe Longpr é-Poirier Nicolas Rohleder Robert-Paul Juster Source Type: research

Commentary: Connecting Cytokines to Distress via Cortisol Concentrations
Brain Behav Immun. 2021 Apr 5:S0889-1591(21)00157-4. doi: 10.1016/j.bbi.2021.03.027. Online ahead of print.NO ABSTRACTPMID:33831472 | DOI:10.1016/j.bbi.2021.03.027 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 8, 2021 Category: Neurology Authors: Enzo Cipriani Philippe Kerr Christophe Longpr é-Poirier Nicolas Rohleder Robert-Paul Juster Source Type: research

Commentary: Connecting Cytokines to Distress via Cortisol Concentrations
Publication date: Available online 6 April 2021Source: Brain, Behavior, and ImmunityAuthor(s): Enzo Cipriani, Philippe Kerr, Christophe Longpré-Poirier, Nicolas Rohleder, Robert-Paul Juster (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 6, 2021 Category: Neurology Source Type: research

Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility
Brain Behav Immun. 2021 Mar 30:S0889-1591(21)00155-0. doi: 10.1016/j.bbi.2021.03.025. Online ahead of print.ABSTRACTMaternal systemic inflammation increases risk for neurodevelopmental disorders like autism, ADHD, and schizophrenia in offspring. Notably, these disorders are male-biased. Studies have implicated immune system dysfunction in the etiology of these disorders, and rodent models of maternal immune activation provide useful tools to examine mechanisms of sex-dependent effects on brain development, immunity, and behavior. Here, we employed an allergen-induced model of maternal inflammation in rats to characterize l...
Source: Brain, Behavior, and Immunity - April 2, 2021 Category: Neurology Authors: Michaela R Breach Courtney N Dye Aarohi Joshi Steven Platko Rachel A Gilfarb Annemarie R Krug Dominic V Franceschelli Anabel Galan Claire M Dodson Kathryn M Lenz Source Type: research

Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility
Brain Behav Immun. 2021 Mar 30:S0889-1591(21)00155-0. doi: 10.1016/j.bbi.2021.03.025. Online ahead of print.ABSTRACTMaternal systemic inflammation increases risk for neurodevelopmental disorders like autism, ADHD, and schizophrenia in offspring. Notably, these disorders are male-biased. Studies have implicated immune system dysfunction in the etiology of these disorders, and rodent models of maternal immune activation provide useful tools to examine mechanisms of sex-dependent effects on brain development, immunity, and behavior. Here, we employed an allergen-induced model of maternal inflammation in rats to characterize l...
Source: Brain, Behavior, and Immunity - April 2, 2021 Category: Neurology Authors: Michaela R Breach Courtney N Dye Aarohi Joshi Steven Platko Rachel A Gilfarb Annemarie R Krug Dominic V Franceschelli Anabel Galan Claire M Dodson Kathryn M Lenz Source Type: research

Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility
Brain Behav Immun. 2021 Mar 30:S0889-1591(21)00155-0. doi: 10.1016/j.bbi.2021.03.025. Online ahead of print.ABSTRACTMaternal systemic inflammation increases risk for neurodevelopmental disorders like autism, ADHD, and schizophrenia in offspring. Notably, these disorders are male-biased. Studies have implicated immune system dysfunction in the etiology of these disorders, and rodent models of maternal immune activation provide useful tools to examine mechanisms of sex-dependent effects on brain development, immunity, and behavior. Here, we employed an allergen-induced model of maternal inflammation in rats to characterize l...
Source: Brain, Behavior, and Immunity - April 2, 2021 Category: Neurology Authors: Michaela R Breach Courtney N Dye Aarohi Joshi Steven Platko Rachel A Gilfarb Annemarie R Krug Dominic V Franceschelli Anabel Galan Claire M Dodson Kathryn M Lenz Source Type: research

Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility
Brain Behav Immun. 2021 Mar 30:S0889-1591(21)00155-0. doi: 10.1016/j.bbi.2021.03.025. Online ahead of print.ABSTRACTMaternal systemic inflammation increases risk for neurodevelopmental disorders like autism, ADHD, and schizophrenia in offspring. Notably, these disorders are male-biased. Studies have implicated immune system dysfunction in the etiology of these disorders, and rodent models of maternal immune activation provide useful tools to examine mechanisms of sex-dependent effects on brain development, immunity, and behavior. Here, we employed an allergen-induced model of maternal inflammation in rats to characterize l...
Source: Brain, Behavior, and Immunity - April 2, 2021 Category: Neurology Authors: Michaela R Breach Courtney N Dye Aarohi Joshi Steven Platko Rachel A Gilfarb Annemarie R Krug Dominic V Franceschelli Anabel Galan Claire M Dodson Kathryn M Lenz Source Type: research

Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J. Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system. Brain Behav Immun. 2015 Jan;43:172-83
Publication date: Available online 21 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 2, 2021 Category: Neurology Source Type: research

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome
Brain Behav Immun. 2021 Mar 29:S0889-1591(21)00153-7. doi: 10.1016/j.bbi.2021.03.023. Online ahead of print.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by fatigue and post-exertional malaise, accompanied by various signs of neurological and autonomic dysfunction. ME/CFS is often triggered by an infectious episode and associated with an aberrant immune system. Here we report that ME/CFS is a disorder characterized by skewed B cell receptor gene usage. By applying a next-generation sequencing to determine the clone-based IGHV/IGHD/IGHJ repertoires, we revealed...
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Wakiro Sato Hirohiko Ono Takaji Matsutani Masakazu Nakamura Isu Shin Keiko Amano Ryuji Suzuki Takashi Yamamura Source Type: research

Check your immune privilege: is there a role for the maternal immune system in the pathogenesis of childhood tics and obsessive-compulsive disorder?
Brain Behav Immun. 2021 Mar 29:S0889-1591(21)00156-2. doi: 10.1016/j.bbi.2021.03.026. Online ahead of print.NO ABSTRACTPMID:33794314 | DOI:10.1016/j.bbi.2021.03.026 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Michael Eyre Ming Lim Source Type: research

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study
CONCLUSIONS: Genetic predisposition to higher systemic inflammatory markers are primarily associated with somatic/neurovegetative symptoms of depression such as changes in appetite and fatigue, consistent with previous studies based on circulating levels of inflammatory markers. We extend these findings by providing evidence that associations are direct (using network analysis) and extend to genetic predisposition to immuno-metabolic markers (using PRSs). Our findings can inform selection of patients with inflammation-related symptoms into clinical trials of immune-modulating drugs for MDD.PMID:33794315 | DOI:10.1016/j.bbi...
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Nils Kappelmann Darina Czamara Nicolas Rost Sylvain Moser Vanessa Schmoll Lucia Trastulla Jan Stochl Susanne Lucae Elisabeth B Binder Golam M Khandaker Janine Arloth CHARGE inflammation working group Source Type: research

Inflammatory Cytokines, Complement Factor H and Anhedonia in Drug-na ïve Major Depressive Disorder
CONCLUSION: MDD patients with anhedonia showed different inflammatory characteristics compared to the patients without anhedonia. Our results provide novel evidence suggesting that increased plasma CFH levels may be a potential biomarker of anhedonia of subtyping MDD.PMID:33794316 | DOI:10.1016/j.bbi.2021.03.022 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Wei Tang Hongyang Liu Lixian Chen Ke Zhao Yaoyao Zhang Ke Zheng Cheng Zhu Tiansheng Zheng Jiahong Liu Dandan Wang Lingfang Yu Xinyu Fang Chen Zhang Kuan-Pin Su Source Type: research

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome
Brain Behav Immun. 2021 Mar 29:S0889-1591(21)00153-7. doi: 10.1016/j.bbi.2021.03.023. Online ahead of print.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by fatigue and post-exertional malaise, accompanied by various signs of neurological and autonomic dysfunction. ME/CFS is often triggered by an infectious episode and associated with an aberrant immune system. Here we report that ME/CFS is a disorder characterized by skewed B cell receptor gene usage. By applying a next-generation sequencing to determine the clone-based IGHV/IGHD/IGHJ repertoires, we revealed...
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Wakiro Sato Hirohiko Ono Takaji Matsutani Masakazu Nakamura Isu Shin Keiko Amano Ryuji Suzuki Takashi Yamamura Source Type: research

Check your immune privilege: is there a role for the maternal immune system in the pathogenesis of childhood tics and obsessive-compulsive disorder?
Brain Behav Immun. 2021 Mar 29:S0889-1591(21)00156-2. doi: 10.1016/j.bbi.2021.03.026. Online ahead of print.NO ABSTRACTPMID:33794314 | DOI:10.1016/j.bbi.2021.03.026 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Michael Eyre Ming Lim Source Type: research

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study
CONCLUSIONS: Genetic predisposition to higher systemic inflammatory markers are primarily associated with somatic/neurovegetative symptoms of depression such as changes in appetite and fatigue, consistent with previous studies based on circulating levels of inflammatory markers. We extend these findings by providing evidence that associations are direct (using network analysis) and extend to genetic predisposition to immuno-metabolic markers (using PRSs). Our findings can inform selection of patients with inflammation-related symptoms into clinical trials of immune-modulating drugs for MDD.PMID:33794315 | DOI:10.1016/j.bbi...
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Nils Kappelmann Darina Czamara Nicolas Rost Sylvain Moser Vanessa Schmoll Lucia Trastulla Jan Stochl Susanne Lucae Elisabeth B Binder Golam M Khandaker Janine Arloth CHARGE inflammation working group Source Type: research

Inflammatory Cytokines, Complement Factor H and Anhedonia in Drug-na ïve Major Depressive Disorder
CONCLUSION: MDD patients with anhedonia showed different inflammatory characteristics compared to the patients without anhedonia. Our results provide novel evidence suggesting that increased plasma CFH levels may be a potential biomarker of anhedonia of subtyping MDD.PMID:33794316 | DOI:10.1016/j.bbi.2021.03.022 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Wei Tang Hongyang Liu Lixian Chen Ke Zhao Yaoyao Zhang Ke Zheng Cheng Zhu Tiansheng Zheng Jiahong Liu Dandan Wang Lingfang Yu Xinyu Fang Chen Zhang Kuan-Pin Su Source Type: research

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome
Brain Behav Immun. 2021 Mar 29:S0889-1591(21)00153-7. doi: 10.1016/j.bbi.2021.03.023. Online ahead of print.ABSTRACTMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by fatigue and post-exertional malaise, accompanied by various signs of neurological and autonomic dysfunction. ME/CFS is often triggered by an infectious episode and associated with an aberrant immune system. Here we report that ME/CFS is a disorder characterized by skewed B cell receptor gene usage. By applying a next-generation sequencing to determine the clone-based IGHV/IGHD/IGHJ repertoires, we revealed...
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Wakiro Sato Hirohiko Ono Takaji Matsutani Masakazu Nakamura Isu Shin Keiko Amano Ryuji Suzuki Takashi Yamamura Source Type: research

Check your immune privilege: is there a role for the maternal immune system in the pathogenesis of childhood tics and obsessive-compulsive disorder?
Brain Behav Immun. 2021 Mar 29:S0889-1591(21)00156-2. doi: 10.1016/j.bbi.2021.03.026. Online ahead of print.NO ABSTRACTPMID:33794314 | DOI:10.1016/j.bbi.2021.03.026 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Michael Eyre Ming Lim Source Type: research

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study
CONCLUSIONS: Genetic predisposition to higher systemic inflammatory markers are primarily associated with somatic/neurovegetative symptoms of depression such as changes in appetite and fatigue, consistent with previous studies based on circulating levels of inflammatory markers. We extend these findings by providing evidence that associations are direct (using network analysis) and extend to genetic predisposition to immuno-metabolic markers (using PRSs). Our findings can inform selection of patients with inflammation-related symptoms into clinical trials of immune-modulating drugs for MDD.PMID:33794315 | DOI:10.1016/j.bbi...
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Nils Kappelmann Darina Czamara Nicolas Rost Sylvain Moser Vanessa Schmoll Lucia Trastulla Jan Stochl Susanne Lucae Elisabeth B Binder Golam M Khandaker Janine Arloth CHARGE inflammation working group Source Type: research

Inflammatory Cytokines, Complement Factor H and Anhedonia in Drug-na ïve Major Depressive Disorder
CONCLUSION: MDD patients with anhedonia showed different inflammatory characteristics compared to the patients without anhedonia. Our results provide novel evidence suggesting that increased plasma CFH levels may be a potential biomarker of anhedonia of subtyping MDD.PMID:33794316 | DOI:10.1016/j.bbi.2021.03.022 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Wei Tang Hongyang Liu Lixian Chen Ke Zhao Yaoyao Zhang Ke Zheng Cheng Zhu Tiansheng Zheng Jiahong Liu Dandan Wang Lingfang Yu Xinyu Fang Chen Zhang Kuan-Pin Su Source Type: research

Inflammatory Cytokines, Complement Factor H and Anhedonia in Drug-naïve Major Depressive Disorder
Publication date: Available online 29 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): Wei Tang, Hongyang Liu, Lixian Chen, Ke Zhao, Yaoyao Zhang, Ke Zheng, Cheng Zhu, Tiansheng Zheng, Jiahong Liu, Dandan Wang, Lingfang Yu, Xinyu Fang, Chen Zhang, Kuan-Pin Su (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Source Type: research

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome
Publication date: Available online 29 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): Wakiro Sato, Hirohiko Ono, Takaji Matsutani, Masakazu Nakamura, Isu Shin, Keiko Amano, Ryuji Suzuki, Takashi Yamamura (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Source Type: research

Check your immune privilege: is there a role for the maternal immune system in the pathogenesis of childhood tics and obsessive-compulsive disorder?
Publication date: Available online 29 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): Michael Eyre, Ming Lim (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Source Type: research

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study
Publication date: Available online 29 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): Nils Kappelmann, Darina Czamara, Nicolas Rost, Sylvain Moser, Vanessa Schmoll, Lucia Trastulla, Jan Stochl, Susanne Lucae, Elisabeth B. Binder, Golam M. Khandaker, Janine Arloth, CHARGE inflammation working group (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Source Type: research

Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility
Publication date: Available online 30 March 2021Source: Brain, Behavior, and ImmunityAuthor(s): Michaela R. Breach, Courtney N. Dye, Aarohi Joshi, Steven Platko, Rachel A. Gilfarb, Annemarie R. Krug, Dominic V. Franceschelli, Anabel Galan, Claire M. Dodson, Kathryn M. Lenz (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Source Type: research

Predicting COVID-19 vaccine take-up: moving beyond demographics
Brain Behav Immun. 2021 Mar 26:S0889-1591(21)00123-9. doi: 10.1016/j.bbi.2021.03.021. Online ahead of print.NO ABSTRACTPMID:33781865 | PMC:PMC7997898 | DOI:10.1016/j.bbi.2021.03.021 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Authors: G David Batty Ian J Deary Source Type: research

Predicting COVID-19 vaccine take-up: moving beyond demographics
Brain Behav Immun. 2021 Mar 26:S0889-1591(21)00123-9. doi: 10.1016/j.bbi.2021.03.021. Online ahead of print.NO ABSTRACTPMID:33781865 | PMC:PMC7997898 | DOI:10.1016/j.bbi.2021.03.021 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2021 Category: Neurology Authors: G David Batty Ian J Deary Source Type: research