Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy
Publication date: Available online 20 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Arindam Ghosh Mazumder, Vikram Patial, Damanpreet SinghAbstractThe role of neuroinflammatory mediators has been well established in the pathogenesis of temporal lobe epilepsy (TLE) and associated neurobehavioral comorbidities. Mycophenolate mofetil (MMF) is commonly used as an immunosuppressant in organ transplantations. Its neuroprotective effect is well explored in different preclinical and clinical studies. The present study was designed to investigate the effect of MMF in rat model of lithium pilocarpine (LiPc)-induced s...
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Perhaps woman are better astronauts?
Publication date: Available online 23 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Christoph Rummel (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives
ConclusionFlavonifractor, a bacterial genus that may induce oxidative stress and inflammation in its host, was associated with BD. Higher prevalence of smoking among patients with BD contributed to our findings, and it cannot be excluded that findings are influenced by residual confounding. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Molecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation
Publication date: Available online 24 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Eduardo A. Saramago, Gabriela S. Borges, Carlitos G. Singolani-Jr, Jonatas E. Nogueira, Renato N. Soriano, Evelin C. Cárnio, Luiz G.S. BrancoAbstractMolecular hydrogen (H2) exerts anti-oxidative, anti-apoptotic, and anti-inflammatory effects. Here we tested the hypothesis that H2 modulates cardiovascular, inflammatory, and thermoregulatory changes in systemic inflammation (SI) induced by lipopolysaccharide (LPS) at different doses (0.1 or 1.5 mg/kg, intravenously, to induce mild or severe SI) in male Wistar rats (25...
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors
This study demonstrated that certain specific TLRs are altered in DS subjects, and hence those TLRs may be appropriate targets for the development of therapeutic agents for the treatment of suicidal behavior. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: a prospective cohort study
ConclusionsDevelopment of fatigue after acute EBV infection is to a larger extent predicted by baseline variables related to symptoms and functions than to baseline variables reflecting infectious and immune processes.Trial registrationClinicalTrials, ID: NCT02335437, https://clinicaltrials.gov/ct2/show/NCT02335437 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Increased placental T cell trafficking results in adverse neurobehavioral outcomes in offspring exposed to sub-chronic maternal inflammation
Publication date: Available online 25 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Christopher M. Novak, Ji Yeon Lee, Maide Ozen, Michael E. Tsimis, Lauren M. Kucirka, Michael W. McLane, Li Xie, Meredith Kelleher, Han Xie, Bei Jia, Jun Lei, Irina BurdAbstractInterleukin-1 beta (IL-1β) is a cytokine mediator of perinatal brain injury. The effect of sub-chronic systemic IL-1β exposure in perinatal and offspring outcomes is unclear. The aim of this study was to examine the effects of maternal IL-1β exposure on pregnancy and offspring outcomes. At E15, CD1 dams were allocated to receive intraper...
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

How to make a better mouse for Brain Behavior and Immunity
Publication date: Available online 26 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Quentin J Pittman (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice
Publication date: Available online 1 October 2018Source: Brain, Behavior, and ImmunityAuthor(s): Run Xiao, Stephen M. Bergin, Wei Huang, Anthony G Mansour, Xianglan Liu, Ryan T Judd, Kyle J. Widstrom, Nicholas J. Queen, Ryan K. Wilkins, Jason J. Siu, Seemaab Ali, Michael A. Caligiuri, Lei CaoAbstractEnvironmental and social factors have profound impacts on immune homeostasis. Our work on environmental enrichment (EE) has revealed a novel anti-obesity and anticancer phenotype associated with enhanced activity of CD8+ cytotoxic T lymphocytes in secondary lymphoid tissues. Here we investigated how an EE modulated thymus and t...
Source: Brain, Behavior, and Immunity - October 5, 2018 Category: Neurology Source Type: research

Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice.
Abstract Environmental and social factors have profound impacts on immune homeostasis. Our work on environmental enrichment (EE) has revealed a novel anti-obesity and anticancer phenotype associated with enhanced activity of CD8+ cytotoxic T lymphocytes in secondary lymphoid tissues. Here we investigated how an EE modulated thymus and thymocyte development. EE decreased thymus mass and cellularity, decreased the double positive thymocyte population, increased the proportion of CD8+ T cells, reduced the CD4:CD8 ratio, and downregulated CD69 expression in T cells. In a model of multiple sclerosis: experimental autoi...
Source: Brain, Behavior, and Immunity - October 1, 2018 Category: Neurology Authors: Xiao R, Bergin SM, Huang W, Mansour AG, Liu X, Judd RT, Widstrom KJ, Queen N, Wilkins R, Siu JJ, Ali S, Caligiuri MA, Cao L Tags: Brain Behav Immun Source Type: research

Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease
ConclusionOur results suggest that neuroinflammation mediated by elevated IL-8 concentrations in CSF and IL-8 mediated periphery-to-CNS inflammatory cross-talk contributes to pain in LDH patients and suggest a link between TSPO expression in discs and low back pain. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 22, 2018 Category: Neurology Source Type: research

LPS-induced histone H3 phospho(Ser10)-acetylation(Lys14) regulates neuronal and microglial neuroinflammatory response
Publication date: Available online 20 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Giovanna Rigillo, Antonietta Vilella, Cristina Benatti, Laurent Schaeffer, Nicoletta Brunello, Johanna M.C. Blom, Michele Zoli, Fabio TasceddaAbstractEpigenetic modifications of DNA and histone proteins are emerging as fundamental mechanisms by which neural cells adapt their transcriptional response to environmental cues, such as, immune stimuli or stress. In particular, histone H3 phospho(Ser10)-acetylation(Lys14) (H3S10phK14ac) has been linked to activation of specific gene expression. The purpose of this study was to inve...
Source: Brain, Behavior, and Immunity - September 21, 2018 Category: Neurology Source Type: research

Mycophenolate mofetil contributes to downregulation of hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in rat model of temporal lobe epilepsy
Publication date: Available online 20 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Arindam Ghosh Mazumder, Vikram Patial, Damanpreet SinghAbstractThe role of neuroinflammatory mediators has been well established in the pathogenesis of temporal lobe epilepsy (TLE) and associated neurobehavioral comorbidities. Mycophenolate mofetil (MMF) is commonly used as an immunosuppressant in organ transplantations and other clinical conditions. Its neuroprotective effect is well explored in different preclinical and clinical studies. The present study was designed to investigate the effect of MMF in rat model of lithiu...
Source: Brain, Behavior, and Immunity - September 20, 2018 Category: Neurology Source Type: research

Stressnology: The Primitive (and Problematic) Study of Life Stress Exposure and Pressing Need for Better Measurement
Publication date: Available online 17 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): George M. SlavichAbstractLife stress is central to many contemporary theories of human health and behavior. Despite this fact, numerous conceptual and measurement issues remain unresolved. The present article explores these topics by first summarizing several key definitional and conceptual matters that are important for life stress research. Second, I introduce stressnology, defined herein as the fictitiously named, but otherwise very real and problematic approach to studying life stress exposure that involves measuring onl...
Source: Brain, Behavior, and Immunity - September 17, 2018 Category: Neurology Source Type: research

Brain glial activation in fibromyalgia – a multi-site positron emission tomography investigation
In this study, we conducted a Positron Emission Tomography (PET) study using [11C]PBR28, which binds to the translocator protein (TSPO), a protein upregulated in activated microglia and astrocytes. To enhance statistical power and generalizability, we combined datasets collected independently at two separate institutions (Massachusetts General Hospital [MGH] and Karolinska Institutet [KI]). In an attempt to disentangle the contributions of different glial cell types to FM, a smaller sample was scanned at KI with [11C]-L-deprenyl-D2 PET, thought to primarily reflect astrocytic (but not microglial) signal.Thirty-one FM patie...
Source: Brain, Behavior, and Immunity - September 15, 2018 Category: Neurology Source Type: research

Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury
Publication date: Available online 12 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Claire-Marie Rangon, Anne-Laure Schang, Juliette Van Steenwinckel, Leslie Schwendimann, Sophie Lebon, Tingting Fu, Libo Chen, Veronique Beneton, Nathalie Journiac, Pierrette Young-Ten, Thomas Bourgeois, Johanna Maze, Boris Matrot, Ana A Baburamani, Veena Supramaniam, Carina Mallard, Lionel Trottet, A David Edwards, Henrik Hagberg, Bobbi FleissAbstractFifteen million babies are born preterm every year and a significant number suffer from permanent neurological injuries linked to white matter injury (WMI). A chief cause of pre...
Source: Brain, Behavior, and Immunity - September 13, 2018 Category: Neurology Source Type: research

Negative and positive affect as predictors of inflammation: Timing matters
We examined how different indicators of NA and PA predicted concentrations of C-reactive protein (CRP) and seven peripheral inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-8, IL-4, IL-10, and IFN-γ) that were examined in the form of an inflammatory composite. A community-based sample of 220 adults (62% Black/African-American and 25% Hispanic/Latino; aged 25-65; 65% female) completed questionnaires at baseline (including recalled affect “over the past month”) and then provided EMA reports 5x/day for 14 days. Blood was drawn from each participant after completion of EMA and used to determine plasm...
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Sickness behavior is not all about the immune response: possible roles of expectations and prediction errors in the worry of being sick
ConclusionThe current findings suggest that the emotional component of sickness behavior is, at least partly, shaped by top-down expectations. Helping patients having a realistic expectation of symptoms during treatment of an illness may thus reduce aggravated emotional responses, and ultimately improve patients’ quality of life and treatment compliance.Registration“Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences”, https://clinicaltrials.gov/ct2/show/NCT02529592, registration number: NCT02529592. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPARγ receptors
In conclusion, our results suggest that CBD could prevent haloperidol-induced orofacial dyskinesia by activating PPARγ receptors and attenuating neuroinflammatory changes in the striatum. Keywords: cannabidiol, tardive dyskinesia, neuroinflammation, oxidative stress, PPARγ receptors. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage
This study enhances our understanding of the role of microglia in viral encephalitis and adds to the concept of microglia-T cell crosstalk. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Pathways Linking Childhood Abuse History and Current Socioeconomic Status to Inflammation During Pregnancy
Publication date: Available online 11 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): M. Sima Finy, Lisa M. ChristianAbstractWomen who have experienced significant adversities during childhood and adulthood are at risk for excessive inflammation during pregnancy, but the mechanisms are unclear. Using structural equation modeling, we examined pathways from childhood abuse history and current socioeconomic status (SES) to inflammatory markers through indicators of health risk, recent stressors, and psychological distress in 214 women assessed at mid-pregnancy (5-31 weeks gestation). Self-reported data on socioe...
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Inflammation in Individuals with Schizophrenia – Implications for Neurocognition and Daily Function
We examined neurocognition (MCCB) and daily functioning (SLOF), as well as inflammatory markers (TNF-α, IL-6, IL-1β, and IL-12p70) in 41 individuals with schizophrenia. Poor neurocognition was significantly associated with increased peripheral TNF-α and IL-12p70 (r=-0.44 and r=-0.38, respectively, controlling for BMI, depression and antipsychotic medication). Notably, difficulties with daily functioning were significantly associated with increased peripheral TNF-α (r=-0.51) and a trend with increased IL-12p70. Our findings support previous hypotheses linking neurocognitive impairment to increased inf...
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Evolution of a maternal immune activation (mIA) model in rats: early developmental effects
Publication date: Available online 12 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Katie N. Murray, Michelle E. Edye, Maurizio Manca, Anthony C. Vernon, Joanna M. Oladipo, Victoria Fasolino, Michael K. Harte, Varsha Mason, Ben Grayson, Patrick C. McHugh, Irene Knuesel, Eric P. Prinssen, Reinmar Hager, Joanna C. NeillAbstractMaternal immune activation (mIA) in rodents is rapidly emerging as a key model for neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Here, we optimise a mIA model in rats, aiming to address certain limitations of current work in this area. Specifical...
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Source Type: research

Does chronic caregiving stress accelerate T cell immunosenescence?
PMID: 30197130 [PubMed - in process] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 12, 2018 Category: Neurology Authors: Whittaker AC Tags: Brain Behav Immun Source Type: research

Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression
Publication date: Available online 10 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Yanling Zhou, Wei Zheng, Weijian Liu, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Mingding Li, Yuping NingAbstractKetamine has rapid antidepressant effects on treatment-resistant depression, but the biological mechanism underpinning this effect is less clear. Our aims were to examine whether kynurenine pathway metabolites were altered by six infusions of ketamine and whether these biological factors could act as potential biomarkers to predict ketamine’s antidepressant effects. Six intravenous infusions of ketami...
Source: Brain, Behavior, and Immunity - September 11, 2018 Category: Neurology Source Type: research

Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury
Publication date: Available online 11 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Marina Dukhinova, Inna Kuznetsova, Ekaterina Kopeykina, Ekaterina Veniaminova, Amanda W.Y. Yung, Tatyana Veremeyko, Kseniia Levchuk, Natasha S. Barteneva, Kenny Kam Wing Ho, Wing-Ho Yung, Julia Y.H. Liu, John Rudd, Sonata S.Y. Yau, Daniel C. Anthony, Tatyana Strekalova, Eugene D. PonomarevAbstractIt is generally accepted that inflammation within the CNS contributes to neurodegeneration after traumatic brain injury (TBI), but it is not clear how inflammation is initiated in the absence of infection and whether this neuroinfla...
Source: Brain, Behavior, and Immunity - September 11, 2018 Category: Neurology Source Type: research

Differential regulation of NF-kB and IRF target genes as they relate to fatigue in patients with head and neck cancer
Publication date: Available online 11 September 2018Source: Brain, Behavior, and ImmunityAuthor(s): Canhua Xiao, Jonathan J. Beitler, Kristin A. Higgins, Evanthia C. Wommack, Nabil F. Saba, Dong M. Shin, Deborah W. Bruner, Andrew H. Miller, Steve ColeAbstractPrevious studies have linked plasma inflammatory markers to elevated fatigue in patients with head and neck cancer (HNC). To identify the molecular mechanisms underlying this association, we conducted promoter-based bioinformatics analyses to determine the relationship between fatigue and specific gene expression profiles associated with inflammation in human papilloma...
Source: Brain, Behavior, and Immunity - September 11, 2018 Category: Neurology Source Type: research

Chronic Interleukin-1β in the Dorsal Hippocampus Impairs Behavioural Pattern Separation
In conclusion, these findings suggest that chronically elevated IL-1β in the hippocampus selectively impairs pattern separation. Inflammatory-mediated disruption of adult neurogenesis may contribute to the cognitive decline associated with neurodegenerative and stress-related disorders. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 11, 2018 Category: Neurology Source Type: research

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion
In this study, we demonstrate that NE blocks the secretion of a variety of proinflammatory cytokines by rapidly inducing IL-10 secretion from innate cells in response to multiple Toll-like receptor (TLR) signals. NE mediated these effects exclusively through the β 2-adrenergic receptor (ADRB2). Consequently, Adrb2-/- animals were more susceptible to L. monocytogenes infection and to intestinal inflammation in a dextran sodium sulfate (DSS) model of colitis. Further, Adrb2-/- animals rapidly succumbed to endotoxemia in response to a sub-lethal LPS challenge and exhibited elevated serum levels of TNF- α and reduce...
Source: Brain, Behavior, and Immunity - September 6, 2018 Category: Neurology Source Type: research

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke
This study has comprehensively investigated the expression and activation of NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes in isolates of microglial cells subjected to simulated ischemic conditions and in the brain following ischemic stroke. Immunoblot analysis from culture media indicated microglial cells release inflammasome components and inflammasome activation-dependent pro-inflammatory cytokines following ischemic conditions. In addition, a functional role for NLRC4 inflammasomes was determined using siRNA knockdown of NLRC4 and pharmacological inhibitors of caspase-1 and -8 to target apoptotic and pyroptotic cell death...
Source: Brain, Behavior, and Immunity - September 6, 2018 Category: Neurology Source Type: research

Editorial Board
Publication date: October 2018Source: Brain, Behavior, and Immunity, Volume 73Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 6, 2018 Category: Neurology Source Type: research

PNIRS Society Announcements
Publication date: October 2018Source: Brain, Behavior, and Immunity, Volume 73Author(s): (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 6, 2018 Category: Neurology Source Type: research

Transcriptome analysis reveals novel genes and immune networks dysregulated in veterans with PTSD
ConclusionsWe identified novel transcriptomic loci and biological pathways for PTSD in service personnel. Network analysis revealed enrichment of loci harboring key candidate genes in PTSD. These findings highlight the role of transcriptional biomarkers in the molecular etiology of PTSD. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 5, 2018 Category: Neurology Source Type: research

MicroRNA-125b mimic inhibits ischemia reperfusion-induced neuroinflammation and aberrant p53 apoptotic signalling activation through targeting TP53INP1
ConclusionsMiR-125b mimic partially protected neurons against neuroinflammation and aberrant p53 network activation-induced apoptosis during IR injury through downregulation of TP53INP1. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 5, 2018 Category: Neurology Source Type: research

Palmitoylethanolamide counteracts autistic-like behaviours in BTBR T+tf/J mice: contribution of central and peripheral mechanisms
In conclusion, our results demonstrated a therapeutic potential of PEA in limiting ASD symptoms, through its pleiotropic mechanism of action, supporting neuroprotection, anti-inflammatory effects, and the modulation of gut-brain axis. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 5, 2018 Category: Neurology Source Type: research

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke.
This study has comprehensively investigated the expression and activation of NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes in isolates of microglial cells subjected to simulated ischemic conditions and in the brain following ischemic stroke. Immunoblot analysis from culture media indicated microglial cells release inflammasome components and inflammasome activation-dependent pro-inflammatory cytokines following ischemic conditions. In addition, a functional role for NLRC4 inflammasomes was determined using siRNA knockdown of NLRC4 and pharmacological inhibitors of caspase-1 and -8 to target apoptotic and pyroptotic cell death...
Source: Brain, Behavior, and Immunity - September 5, 2018 Category: Neurology Authors: Poh L, Kang SW, Baik SH, Yong Quan Ng G, She DT, Balaganapathy P, Thameem Dheen S, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV Tags: Brain Behav Immun Source Type: research

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion.
In this study, we demonstrate that NE blocks the secretion of a variety of proinflammatory cytokines by rapidly inducing IL-10 secretion from innate cells in response to multiple Toll-like receptor (TLR) signals. NE mediated these effects exclusively through the β 2-adrenergic receptor (ADRB2). Consequently, Adrb2-/- animals were more susceptible to L. monocytogenes infection and to intestinal inflammation in a dextran sodium sulfate (DSS) model of colitis. Further, Adrb2-/- animals rapidly succumbed to endotoxemia in response to a sub-lethal LPS challenge and exhibited elevated serum levels of TNF- α and reduce...
Source: Brain, Behavior, and Immunity - September 5, 2018 Category: Neurology Authors: Ağaç D, Estrada LD, Maples R, Hooper LV, David Farrar J Tags: Brain Behav Immun Source Type: research

MicroRNA-125b mimic inhibits ischemia reperfusion-induced neuroinflammation and aberrant p53 apoptotic signalling activation through targeting TP53INP1.
CONCLUSIONS: MiR-125b mimic partially protected neurons against neuroinflammation and aberrant p53 network activation-induced apoptosis during IR injury through downregulation of TP53INP1. PMID: 30193876 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 4, 2018 Category: Neurology Authors: Li XQ, Yu Q, Tan WF, Zhang ZL, Ma H Tags: Brain Behav Immun Source Type: research

Palmitoylethanolamide counteracts autistic-like behaviours in BTBR T+tf/J mice: contribution of central and peripheral mechanisms.
In conclusion, our results demonstrated a therapeutic potential of PEA in limiting ASD symptoms, through its pleiotropic mechanism of action, supporting neuroprotection, anti-inflammatory effects, and the modulation of gut-brain axis. PMID: 30193877 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 4, 2018 Category: Neurology Authors: Cristiano C, Pirozzi C, Coretti L, Cavaliere G, Lama A, Russo R, Lembo F, Pina Mollica M, Meli R, Calignano A, Mattace Raso G Tags: Brain Behav Immun Source Type: research

Transcriptome analysis reveals novel genes and immune networks dysregulated in veterans with PTSD.
CONCLUSIONS: We identified novel transcriptomic loci and biological pathways for PTSD in service personnel. Network analysis revealed enrichment of loci harboring key candidate genes in PTSD. These findings highlight the role of transcriptional biomarkers in the molecular etiology of PTSD. PMID: 30189241 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 3, 2018 Category: Neurology Authors: Mehta D, Voisey J, Bruenig D, Harvey W, Morris CP, Lawford B, Young RM Tags: Brain Behav Immun Source Type: research

β2-adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans
Publication date: Available online 30 August 2018Source: Brain, Behavior, and ImmunityAuthor(s): Rachel M. Graff, Hawley E. Kunz, Nadia H. Agha, Forrest L. Baker, Mitzi Laughlin, Austin B. Bigley, Melissa M. Markofski, Emily C. LaVoy, Emmanuel Katsanis, Richard A. Bond, Catherine M. Bollard, Richard J. SimpsonAbstractAcute exercise preferentially mobilizes cytotoxic T-cells, NK-cells and non-classical monocytes to the bloodstream under the influence of hemodynamic forces and/or β2-adrenergic receptor (β2-AR) signaling. However, the relative contribution of these mechanisms to the redeployment of the most exercise...
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Source Type: research

Posttraumatic Stress Disorder is Associated with Enhanced Interleukin-6 Response to Mental Stress in Subjects with a Recent Myocardial Infarction
ConclusionMI patients with current PTSD exhibit enhanced IL-6 response to psychosocial stress, suggesting a mechanistic link between PTSD and adverse cardiovascular outcomes as well as other diseases associated with inflammation. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Source Type: research

Commentary on the 2018 Named Series on Blood-brain interfaces: roles of neuroimmunomodulation in health and disease
Publication date: Available online 30 August 2018Source: Brain, Behavior, and ImmunityAuthor(s): Michelle A. Erickson, Joseph A. Nicolazzo, William A. BanksAbstractThis year’s 2018 Named Series on blood-brain interfaces highlights the importance of brain barriers as mediators of neuroimmune communication and regulators of neurological function. The term “brain interfaces” reflects our growing understanding that brain barriers such as the blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) are not only gatekeepers, but facilitators of bidirectional communication between the brain and periphery. There i...
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Source Type: research

The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain
This study presents a greater understanding of the differences in neuropathic pain among genetically heterogeneous inbred mouse strains, and provides further insights into the spatial and temporal roles of the immune system in the pathogenesis of neuropathic pain. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Source Type: research

Tempora mutantur et nos mutamur in illis [the times are changing, and we change in them]
Publication date: Available online 29 August 2018Source: Brain, Behavior, and ImmunityAuthor(s): Rainer H. Straub (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Source Type: research

Posttraumatic Stress Disorder is Associated with Enhanced Interleukin-6 Response to Mental Stress in Subjects with a Recent Myocardial Infarction.
CONCLUSION: MI patients with current PTSD exhibit enhanced IL-6 response to psychosocial stress, suggesting a mechanistic link between PTSD and adverse cardiovascular outcomes as well as other diseases associated with inflammation. PMID: 30172946 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Authors: Lima BB, Hammadah M, Wilmot K, Pearce BD, Shah A, Levantsevych O, Kaseer B, Obideen M, Gafeer MM, Kim JH, Sullivan S, Lewis TT, Weng L, Elon L, Li L, Bremner JD, Raggi P, Quyyumi A, Vaccarino V Tags: Brain Behav Immun Source Type: research

Commentary on the 2018 Named Series on Blood-brain interfaces: roles of neuroimmunomodulation in health and disease.
Abstract This year's 2018 Named Series on blood-brain interfaces highlights the importance of brain barriers as mediators of neuroimmune communication and regulators of neurological function. The term "brain interfaces" reflects our growing understanding that brain barriers such as the blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) are not only gatekeepers, but facilitators of bidirectional communication between the brain and periphery. There is also an emerging appreciation that CNS sites that are exposed to blood-borne immune molecules and cells, such as the leptomeninges and circumventricular...
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Authors: Erickson MA, Nicolazzo JA, Banks WA Tags: Brain Behav Immun Source Type: research

β2-adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans.
β2-adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018 Aug 30;: Authors: Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ Abstract Acute exercise preferentially mobilizes cytotoxic T-cells, NK-cells and non-classical monocytes to the bloodstream under the influence of hemodynamic forces and/or β2-adrenergic receptor (β2-AR) signaling. However, the r...
Source: Brain, Behavior, and Immunity - August 30, 2018 Category: Neurology Authors: Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ Tags: Brain Behav Immun Source Type: research

The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain.
This study presents a greater understanding of the differences in neuropathic pain among genetically heterogeneous inbred mouse strains, and provides further insights into the spatial and temporal roles of the immune system in the pathogenesis of neuropathic pain. PMID: 30171890 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - August 29, 2018 Category: Neurology Authors: Isami K, Imai S, Sukeishi A, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S Tags: Brain Behav Immun Source Type: research

High-fat diet and post-operative pain: why the hospital cafeteria may matter
Publication date: Available online 18 August 2018Source: Brain, Behavior, and ImmunityAuthor(s): Judith A. Strong (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - August 18, 2018 Category: Neurology Source Type: research