Lung pathology due to hRSV infection impairs blood-brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS
Publication date: Available online 24 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Karen Bohmwald, Jorge A. Soto, Catalina Andrade, Ayleen Fernández-Fierro, Janyra A. Espinoza, Mariana Ríos, Eliseo A. Eugenin, Pablo A. González, María Cecilia Opazo, Claudia A. Riedel, Alexis M. Kalergis (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 26, 2020 Category: Neurology Source Type: research

Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders – A comprehensive systematic review and meta-analysis
Publication date: Available online 3 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Rose Jeppesen, Rune H.B. Christensen, Emilie M.J. Pedersen, Merete Nordentoft, Carsten Hjorthøj, Ole Köhler-Forsberg, Michael E. Benros (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 25, 2020 Category: Neurology Source Type: research

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice
Publication date: Available online 23 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): M. Chataigner, P. Mortessagne, C. Lucas, V. Pallet, S. Layé, A. Mehaignerie, E. Bouvret, AL. Dinel, C. Joffre (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 25, 2020 Category: Neurology Source Type: research

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
Publication date: Available online 22 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Sahabuddin Ahmed, Mohit Kwatra, Samir Ranjan Panda, USN Murty, VGM Naidu (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 23, 2020 Category: Neurology Source Type: research

Lower CSF Homovanillic Acid Relates to Higher Burden of Neuroinflammation and Depression in People with HIV Disease
Publication date: Available online 20 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Rowan Saloner, Mariana Cherner, David J. Grelotti, Emily W. Paolillo, David J. Moore, Robert K. Heaton, Scott L. Letendre, Adarsh Kumar, Igor Grant, Ronald J. Ellis (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 22, 2020 Category: Neurology Source Type: research

Relationships of Inflammation Trajectories with White Matter Volume and Integrity in Midlife
Publication date: Available online 20 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Aoife O'Donovan, Amber Bahorik, Stephen Sidney, Lenore J. Launer, Kristine Yaffe (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 22, 2020 Category: Neurology Source Type: research

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease.
In this study we have developed a model of inflammasome activation by combining LPS with a mitochondrial complex-I inhibitor MPP+. The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1β) and IL-18. LPS-MPP+ combination was seen to impaired the mitophagy by inhibiting the initial step of autophagosome formation as evidenced by protein expression and confocal imaging data. Treatment with Andrographolide promote...
Source: Brain, Behavior, and Immunity - September 21, 2020 Category: Neurology Authors: Ahmed S, Kwatra M, Ranjan Panda S, Murty U, Naidu V Tags: Brain Behav Immun Source Type: research

INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats
Publication date: Available online 19 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Xiao Hu, Jun Yan, Lei Huang, Camila Araujo, Jun Peng, Ling Gao, Shengpeng Liu, Jiping Tang, Gang Zuo, John H. Zhang (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 20, 2020 Category: Neurology Source Type: research

Lower CSF Homovanillic Acid Relates to Higher Burden of Neuroinflammation and Depression in People with HIV Disease.
CONCLUSIONS: Results suggest that the pathophysiology of depression in PWH differs from that in HIV- individuals. Specifically, lower central dopaminergic activity was selectively associated with greater depressive symptoms and neuroinflammation in PWH. With the rise in consideration of DA agonists for the treatment of depression, these results suggest that PWH may show a greater response to these agents than their HIV- peers. PMID: 32966871 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 20, 2020 Category: Neurology Authors: Saloner R, Cherner M, Grelotti DJ, Paolillo EW, Moore DJ, Heaton RK, Letendre SL, Kumar A, Grant I, Ellis RJ Tags: Brain Behav Immun Source Type: research

Relationships of Inflammation Trajectories with White Matter Volume and Integrity in Midlife.
CONCLUSION: Increasing or high inflammation trajectories from early to mid adulthood are associated with worse brain health, as indexed by lower white matter volume and/or worse white matter integrity. PMID: 32966872 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 20, 2020 Category: Neurology Authors: O'Donovan A, Bahorik A, Sidney S, Launer LJ, Yaffe K Tags: Brain Behav Immun Source Type: research

The role of substance P in acupuncture signal transduction and effects
Publication date: Available online 18 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Yu Fan, Do-Hee Kim, Young Seob Gwak, Danbi Ahn, Yeonhee Ryu, Suchan Chang, Bong Hyo Lee, Kyle B. Bills, Scott C. Steffensen, Chae Ha Yang, Hee Young Kim (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 19, 2020 Category: Neurology Source Type: research

Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-β accumulation and improves cognition in APP/PS1 mice
Publication date: Available online 19 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Zhiwei Xing, Zejie Zuo, Dandan Hu, Xiaona Zheng, Xiao Wang, Lifang Yuan, Lihua Zhou, Fangfang Qi, Zhibin Yao (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 19, 2020 Category: Neurology Source Type: research

IgA natural antibodies are produced following T-cell independent B-cell activation following stroke
Publication date: Available online 19 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jacob C. Zbesko, Jennifer Beischel Frye, Danielle A. Becktel, Diana K. Gerardo, Jessica Stokes, Kylie Calderon, Thuy-Vi V. Nguyen, Deepta Bhattacharya, Kristian P. Doyle (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 19, 2020 Category: Neurology Source Type: research

INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
CONCLUSIONS: INT-777 attenuated NLRP3-ASC inflammasome-dependent neuroinflammation in the EBI after SAH, partially via TGR5/cAMP/PKA signaling pathway. Early administration of INT-777 may serve as a potential therapeutic strategy for EBI management in the setting of SAH. PMID: 32961266 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 19, 2020 Category: Neurology Authors: Hu X, Yan J, Huang L, Araujo C, Peng J, Gao L, Liu S, Tang J, Zuo G, Zhang JH Tags: Brain Behav Immun Source Type: research

Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming
Publication date: Available online 17 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Okito Hashimoto, Hiroshi Kuniishi, Yuko Nakatake, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguchi (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 18, 2020 Category: Neurology Source Type: research

Inflammatory and Cardiometabolic Markers at Presentation with First Episode Psychosis and Long-term Clinical Outcomes: a longitudinal study using electronic health records
Publication date: Available online 17 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Emanuele F. Osimo, Benjamin I. Perry, Rudolf N. Cardinal, Mary-Ellen Lynall, Jonathan Lewis, Aarti Kudchadkar, Graham Murray, Jesus Perez, Peter B. Jones, Golam M. Khandaker (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 18, 2020 Category: Neurology Source Type: research

Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients
Publication date: Available online 17 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Huai-Hsuan Tseng, Hui Hua Chang, Shyh-Yuh Wei, Tsung-Hua Lu, Yi-Ting Hsieh, Yen Kuang Yang, Po See Chen (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 18, 2020 Category: Neurology Source Type: research

Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid- β accumulation and improves cognition in APP/PS1 mice.
Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-β accumulation and improves cognition in APP/PS1 mice. Brain Behav Immun. 2020 Sep 18;: Authors: Xing Z, Zuo Z, Hu D, Zheng X, Wang X, Yuan L, Zhou L, Qi F, Yao Z Abstract Immune dysfunction is implicated in Alzheimer's disease (AD), whereas systemic immune modulation may be neuroprotective. Our previous results have indicated immune challenge with Bacillus Calmette-Guerin attenuates AD pathology in animal models by boosting the systemic immune system. Similarly, independent studies have shown that boosting systemic immune...
Source: Brain, Behavior, and Immunity - September 18, 2020 Category: Neurology Authors: Xing Z, Zuo Z, Hu D, Zheng X, Wang X, Yuan L, Zhou L, Qi F, Yao Z Tags: Brain Behav Immun Source Type: research

IgA natural antibodies are produced following T-cell independent B-cell activation following stroke.
Abstract Up to 30% of stroke patients experience cognitive decline within one year of their stroke. There are currently no FDA-approved drugs that can prevent post-stroke cognitive decline, in part due to a poor understanding of the mechanisms involved. We have previously demonstrated that a B-lymphocyte response to stroke, marked by IgA+ cells, can cause delayed cognitive dysfunction in mice and that a similar adaptive immune response occurs in the brains of some human stroke patients that suffer from vascular dementia. The stimuli which trigger B-lymphocyte activation following stroke, and their target antigens,...
Source: Brain, Behavior, and Immunity - September 18, 2020 Category: Neurology Authors: Zbesko JC, Frye JB, Becktel DA, Gerardo DK, Stokes J, Calderon K, Nguyen TV, Bhattacharya D, Doyle KP Tags: Brain Behav Immun Source Type: research

The role of substance P in acupuncture signal transduction and effects.
CONCLUSIONS: Our findings suggest that SP released during neurogenic inflammation enhances the responses of sensory afferents to the needling of acupoints and triggers acupuncture signaling to generate acupuncture effects. PMID: 32956833 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 18, 2020 Category: Neurology Authors: Fan Y, Kim DH, Seob Gwak Y, Ahn D, Ryu Y, Chang S, Hyo Lee B, Bills KB, Steffensen SC, Ha Yang C, Young Kim H Tags: Brain Behav Immun Source Type: research

Inflammatory and Cardiometabolic Markers at Presentation with First Episode Psychosis and Long-term Clinical Outcomes: a longitudinal study using electronic health records.
In conclusion, we provide evidence that triglyceride levels and several blood cell counts measured at presentation may be clinically useful markers of long-term prognosis of first episode psychosis in clinical settings. These findings will require replication. PMID: 32950620 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 17, 2020 Category: Neurology Authors: Osimo EF, Perry BI, Cardinal RN, Lynall ME, Lewis J, Kudchadkar A, Murray G, Perez J, Jones PB, Khandaker GM Tags: Brain Behav Immun Source Type: research

Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients.
Abstract Bipolar disorder (BD) has been linked to abnormal frontal and striatal function, and elevated inflammatory responses. However, the impact of peripheral inflammation on the corticostriatal functional connectivity (FC) remains obscure in BD. The current study aimed to explore the association between peripheral inflammation and corticostriatal connectivity in euthymic BD. We recruited 25 euthymic BD patients and 43 healthy controls (HCs) from the community. Resting state functional images were obtained using 3T magnetic resonance imaging (fMRI), and striatal seed-based whole-brain functional connectivity ana...
Source: Brain, Behavior, and Immunity - September 17, 2020 Category: Neurology Authors: Tseng HH, Hua Chang H, Wei SY, Lu TH, Hsieh YT, Kuang Yang Y, See Chen P Tags: Brain Behav Immun Source Type: research

Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming.
Abstract Allergic dermatitis (AD), associated with pruritus and itchiness, is one of the major stressful conditions early in life. AD also influences the incidence of neuropsychiatric disorders and developmental disorders through neuro-immune interactions. To the best of our knowledge, there is no report that assesses the effects of early childhood dermatitis on psychiatric disorders later in life using an animal model. Here, we developed an oxazolone (Ox)-induced AD model in the early life of male C57BL/6J mice whose ears were challenged by Ox repeatedly from postnatal days (PD) 2 to PD30. On PD30, the Ox-treated...
Source: Brain, Behavior, and Immunity - September 17, 2020 Category: Neurology Authors: Hashimoto O, Kuniishi H, Nakatake Y, Yamada M, Wada K, Sekiguchi M Tags: Brain Behav Immun Source Type: research

Differential levels of inflammatory and neuroendocrine markers in the hippocampus and anterior cingulate cortex of bipolar disorder subjects: a post-mortem study
Publication date: Available online 16 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Camila Nascimento, Paula Villela Nunes, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Renata Elaine Paraizo Leite, Lea Tenenholz Grinberg, Carlos Augusto Pasqualucci, Ricardo Nitrini, Wilson Jacob-Filho, Helena Paula Brentani, Beny Lafer (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 16, 2020 Category: Neurology Source Type: research

Differential levels of inflammatory and neuroendocrine markers in the hippocampus and anterior cingulate cortex of bipolar disorder subjects: a post-mortem study.
PMID: 32949690 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 16, 2020 Category: Neurology Authors: Nascimento C, Villela Nunes P, Kimie Suemoto C, Diehl Rodriguez R, Elaine Paraizo Leite R, Tenenholz Grinberg L, Augusto Pasqualucci C, Nitrini R, Jacob-Filho W, Paula Brentani H, Lafer B Tags: Brain Behav Immun Source Type: research

Best Practice Recommendations for the Measurement and Interpretation of Salivary Proinflammatory Cytokines in Biobehavioral Research
Publication date: Available online 12 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jenna L. Riis, Hedyeh Ahmadi, Katrina R. Hamilton, Tracey Hand, Douglas A. Granger (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 14, 2020 Category: Neurology Source Type: research

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury
Publication date: Available online 12 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Amanda Costa, Verena Haage, Seulkee Yang, Stephanie Wegner, Burcu Ersoy, Bilge Ugursu, Andre Rex, Golo Kronenberg, Karen Gertz, Matthias Endres, Susanne A. Wolf, Helmut Kettenmann (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 13, 2020 Category: Neurology Source Type: research

Best Practice Recommendations for the Measurement and Interpretation of Salivary Proinflammatory Cytokines in Biobehavioral Research.
Abstract Despite the integration of salivary inflammatory cytokines into research across the biobehavioral, psychological, clinical, and health-related disciplines, there is little guidance regarding the biospecimen collection, handling, and storage practices that maximize the quality and validity of salivary cytokine data. Furthermore, associations between salivary cytokines and measures related to oral health are rarely assessed and accounted for in studies outside the oral health fields. To address these gaps, we examine the sensitivity of salivary interleukin-1β (IL-1β), IL-6, IL-8, and tumor necrosi...
Source: Brain, Behavior, and Immunity - September 12, 2020 Category: Neurology Authors: Riis JL, Ahmadi H, Hamilton KR, Hand T, Granger DA Tags: Brain Behav Immun Source Type: research

Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birth
Publication date: Available online 10 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Gemma Sullivan, Paola Galdi, Manuel Blesa Cabez, Nis Borbye-Lorenzen, David Q. Stoye, Gillian J. Lamb, Margaret J. Evans, Alan J. Quigley, Michael J. Thrippleton, Kristin Skogstrand, Siddharthan Chandran, Mark E. Bastin, James P. Boardman (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 11, 2020 Category: Neurology Source Type: research

Patterning of educational attainment across inflammatory markers: findings from a multi-cohort study
Publication date: Available online 10 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Marine Maurel, Raphaële Castagné, Eloïse Berger, Murielle Bochud, Marc Chadeau-Hyam, Silvia Fraga, Martina Gandini, Nina Hutri-Kähönen, Sirpa Jalkanen, Mika Kivimäki, Michael Marmot, Cathal McCrory, Martin Preisig, Olli Raitakari, Fulvio Ricceri, Marko Salmi, Andrew Steptoe, Paolo Vineis, Cyrille Delpierre, Michelle Kelly-Irving (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 11, 2020 Category: Neurology Source Type: research

Maternal Immune Activity During Pregnancy and Socioeconomic Disparities in Children’s Self-Regulation
Publication date: Available online 10 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jing Yu, Akhgar Ghassabian, Zhen Chen, Risë B. Goldstein, Mady Hornig, Stephen L. Buka, Jill M. Goldstein, Stephen E. Gilman (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 11, 2020 Category: Neurology Source Type: research

Longitudinal Relationships of Cytokines, Depression and Anhedonia in Depressed Adolescents
Publication date: Available online 10 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Manivel Rengasamy, Anna Marsland, Lora McClain, Tessa Kovats, Thomas Walko, Lisa Pan, Rebecca B. Price (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 11, 2020 Category: Neurology Source Type: research

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
In conclusion, our data suggest that the upregulation of m3R in microglia and monocytes in stroke has a beneficial effect on the clinical outcome in male mice. PMID: 32927021 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 11, 2020 Category: Neurology Authors: Costa A, Haage V, Yang S, Wegner S, Ersoy B, Ugursu B, Rex A, Kronenberg G, Gertz K, Endres M, Wolf SA, Kettenmann H Tags: Brain Behav Immun Source Type: research

Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments
Publication date: Available online 8 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Yu Peng, Zhe Shi, Senthil Kumaran Satyanarayanan, Chengwei He, Peng Li, Jian-Bo Wan, Huanxing Su (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 10, 2020 Category: Neurology Source Type: research

Sex Differences in the Inflammatory Response to Stress and Risk of Adverse Cardiovascular Outcomes among Patients with Coronary Heart Disease
Publication date: Available online 8 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Samaah Sullivan, An Young, Muhammad Hammadah, Bruno B. Lima, Oleksiy Levantsevych, Yi-An Ko, Brad D. Pearce, Amit J. Shah, Jeong Hwan Kim, Kasra Moazzami, Emily G. Driggers, Ammer Haffar, Laura Ward, Isaias Herring, Allison Hankus, Tené T. Lewis, Puja K. Mehta, J. Douglas Bremner, Paolo Raggi, Arshed Quyyumi (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 10, 2020 Category: Neurology Source Type: research

Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birth.
Abstract BACKGROUND: Preterm birth is associated with dysconnectivity of structural brain networks, impaired cognition and psychiatric disease. Systemic inflammation contributes to cerebral dysconnectivity, but the immune mediators driving this association are poorly understood. We analysed information from placenta, umbilical cord and neonatal blood, and brain MRI to determine which immune mediators link perinatal systemic inflammation with dysconnectivity of structural brain networks. METHODS: Participants were 102 preterm infants (mean gestational age 29+1 weeks, range 23+3-32+0). Placental histopathology ...
Source: Brain, Behavior, and Immunity - September 10, 2020 Category: Neurology Authors: Sullivan G, Galdi P, Blesa Cabez M, Borbye-Lorenzen N, Stoye DQ, Lamb GJ, Evans MJ, Quigley AJ, Thrippleton MJ, Skogstrand K, Chandran S, Bastin ME, Boardman JP Tags: Brain Behav Immun Source Type: research

Patterning of educational attainment across inflammatory markers: findings from a multi-cohort study.
CONCLUSIONS: Our study suggests different educational patterning of inflammatory biomarkers . Further large-scale research is needed to explore social differences in the inflammatory cascade in greater detail and the extent to which these differences contribute to social inequalities in health. PMID: 32919037 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 9, 2020 Category: Neurology Authors: Maurel M, Castagné R, Berger E, Bochud M, Chadeau-Hyam M, Fraga S, Gandini M, Hutri-Kähönen N, Jalkanen S, Kivimäki M, Marmot M, McCrory C, Preisig M, Raitakari O, Ricceri F, Salmi M, Steptoe A, Vineis P, Delpierre C, Kelly-Irving M Tags: Brain Behav Immun Source Type: research

Longitudinal Relationships of Cytokines, Depression and Anhedonia in Depressed Adolescents.
CONCLUSIONS: Among adolescents receiving standard-of-care community treatment for depression, higher levels of TNFα predicted greater depressive symptoms at 4-month follow-up, suggesting this cytokine may be used to help identify patients in need of more intensive treatment. Elevated TNFα levels were also associated with concurrent and future anhedonia symptoms, suggesting a specific mechanism in which TNFα affects depression trajectories. Future studies should examine the relationships between cytokine levels and depression/anhedonia symptoms at multiple timepoints in larger cohorts of depressed adolesce...
Source: Brain, Behavior, and Immunity - September 9, 2020 Category: Neurology Authors: Rengasamy M, Marsland A, McClain L, Kovats T, Walko T, Pan L, Price RB Tags: Brain Behav Immun Source Type: research

Maternal Immune Activity During Pregnancy and Socioeconomic Disparities in Children's Self-Regulation.
This study examined whether concentrations of five cytokines assayed from prenatal serum were associated with socioeconomic status (SES) and racial disparities in their offspring's self-regulation abilities. Participants included 1,628 women in the Collaborative Perinatal Project (CPP). Seven behavioral items conceptually related to self-regulation were rated by CPP psychologists when children were 4 years old. Concentrations of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and IL-10 were assessed. Covariates included child sex and mother's age, psychiatric disorders, and medical conditions dur...
Source: Brain, Behavior, and Immunity - September 9, 2020 Category: Neurology Authors: Yu J, Ghassabian A, Chen Z, Goldstein RB, Hornig M, Buka SL, Goldstein JM, Gilman SE Tags: Brain Behav Immun Source Type: research

Sex Differences in the Inflammatory Response to Stress and Risk of Adverse Cardiovascular Outcomes among Patients with Coronary Heart Disease.
We examined inflammatory biomarkers known to increase with mental stress (speech task), including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and matrix metallopeptidase-9 (MMP-9) among 562 patients with stable CHD. Inflammatory response, the difference between post-stress and resting values, was examined as a predictor of major adverse cardiovascular events (MACE) using subdistribution hazards models for competing risks adjusting for demographics, cardiovascular risk factors, and medications. MACE was defined as a composite endpoint of cardiovascular death, myocardial infarction, unstable angina with...
Source: Brain, Behavior, and Immunity - September 8, 2020 Category: Neurology Authors: Sullivan S, Young A, Hammadah M, Lima BB, Levantsevych O, Ko YA, Pearce BD, Shah AJ, Hwan Kim J, Moazzami K, Driggers EG, Haffar A, Ward L, Herring I, Hankus A, Lewis TT, Mehta PK, Douglas Bremner J, Raggi P, Quyyumi A, Vaccarino V Tags: Brain Behav Immun Source Type: research

Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments.
Abstract Our previous study revealed that fish oil (FO) pre-treatment could improve the lipopolysaccharides (LPS)-induced depressive-like behavior in mice but did not alter the expression of stress hormones associated with the hypothalamic-pituitary-adrenal (HPA) axis. The exact mechanisms underlying the protective effects of FO remain elusive. Here we applied the metabolomic technique to investigate the potential involvement of FO metabolites in ameliorating depressive-like behaviors in LPS-injected mice. It revealed that LPS-injection stimulated systemic inflammation, exhausted the nicotinamide adenine dinucleot...
Source: Brain, Behavior, and Immunity - September 8, 2020 Category: Neurology Authors: Peng Y, Shi Z, Kumaran Satyanarayanan S, He C, Li P, Wan JB, Su H Tags: Brain Behav Immun Source Type: research

Associations between urinary biomarkers of oxidative stress in the third trimester of pregnancy and behavioral outcomes in the child at 4 years of age
Publication date: Available online 6 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Anna-Sophie Rommel, Ginger L. Milne, Emily S. Barrett, Nicole R. Bush, Ruby Nguyen, Sheela Sathyanarayana, Shanna H. Swan, Kelly K. Ferguson (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 7, 2020 Category: Neurology Source Type: research

Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum
Publication date: Available online 6 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Santiago G. Lago, Jakub Tomasik, Geertje F. van Rees, Marina Rubey, Emiliano Gonzalez-Vioque, Jordan M. Ramsey, Frieder Haenisch, Jantine A. Broek, Javier Vázquez-Bourgon, Sergi Papiol, Paula Suarez-Pinilla, Tillmann Ruland, Bonnie Auyeug, Olya Mikova, Nikolett Kabacs, Volker Arolt, Simon Baron-Cohen, Benedicto Crespo-Facorro, Sabine Bahn (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 7, 2020 Category: Neurology Source Type: research

Associations between urinary biomarkers of oxidative stress in the third trimester of pregnancy and behavioral outcomes in the child at 4 years of age.
PMID: 32905853 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 6, 2020 Category: Neurology Authors: Rommel AS, Milne GL, Barrett ES, Bush NR, Nguyen R, Sathyanarayana S, Swan SH, Ferguson KK Tags: Brain Behav Immun Source Type: research

Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum.
ahn S Abstract Recent evidence suggests that comorbidities between neuropsychiatric conditions and metabolic syndrome may precede and even exacerbate long-term side-effects of psychiatric medication, such as a higher risk of type 2 diabetes and cardiovascular disease, which result in increased mortality. In the present study we compare the expression of key metabolic proteins, including the insulin receptor (CD220), glucose transporter 1 (GLUT-1) and fatty acid translocase (CD36), on peripheral blood mononuclear cell subtypes from patients across the neuropsychiatric spectrum, including schizophrenia, bipolar diso...
Source: Brain, Behavior, and Immunity - September 5, 2020 Category: Neurology Authors: Lago SG, Tomasik J, van Rees GF, Rubey M, Gonzalez-Vioque E, Ramsey JM, Haenisch F, Broek JA, Vázquez-Bourgon J, Papiol S, Suarez-Pinilla P, Ruland T, Auyeug B, Mikova O, Kabacs N, Arolt V, Baron-Cohen S, Crespo-Facorro B, Bahn S Tags: Brain Behav Immun Source Type: research

Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress
Publication date: Available online 3 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Safwan K. Elkhatib, Cassandra M. Moshfegh, Gabrielle F. Watson, Adam J. Case (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 4, 2020 Category: Neurology Source Type: research

Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders - a comprehensive systematic review and meta-analysis
Publication date: Available online 3 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Rose Jeppesen, Rune H.B. Christensen, Emilie M.J. Pedersen, Merete Nordentoft, Carsten Hjorthøj, Ole Köhler-Forsberg, Michael E. Benros (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 4, 2020 Category: Neurology Source Type: research

Expanding the focus on female brain and behaviour
Publication date: Available online 28 August 2020Source: Brain, Behavior, and ImmunityAuthor(s): Luba Sominsky (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 2, 2020 Category: Neurology Source Type: research

Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: a focus on microbiota-gut-brain-immune axis
Publication date: Available online 1 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Senthil Kumaran Satyanarayanan, Jiaqi Tong, Huanxing Su (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 2, 2020 Category: Neurology Source Type: research

Investigating whether depressed youth exhibiting elevated C reactive protein perform worse on measures of executive functioning, verbal fluency and episodic memory in a large, population based sample of Dutch adolescents
Publication date: Available online 2 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Naoise Mac Giollabhui, Lauren B. Alloy, Catharina A. Hartman (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 2, 2020 Category: Neurology Source Type: research