Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research

Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research

Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research

Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00409-9. doi: 10.1016/j.bbi.2023.12.027. Online ahead of print.ABSTRACTThe focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to: conceptual imprecision, research bias, limitations with binary descriptions, integrating sex and gender, and ti...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Edmund Keogh Katelynn E Boerner Source Type: research

Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00410-5. doi: 10.1016/j.bbi.2023.12.028. Online ahead of print.ABSTRACTPost-operative cognitive dysfunction (POCD) is an abrupt decline in neurocognitive function arising shortly after surgery and persisting for weeks to months, increasing the risk of dementia diagnosis. Advanced age, obesity, and comorbidities linked to high-fat diet (HFD) consumption such as diabetes and hypertension have been identified as risk factors for POCD, although underlying mechanisms remain unclear. We have previously shown that surgery alone, or 3-days of HFD can each evoke sufficient neuroinflammat...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Stephanie M Muscat Michael J Butler Menaz N Bettes James DeMarsh Emmanuel A Scaria Nicholas P Deems Ruth M Barrientos Source Type: research

Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00409-9. doi: 10.1016/j.bbi.2023.12.027. Online ahead of print.ABSTRACTThe focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to: conceptual imprecision, research bias, limitations with binary descriptions, integrating sex and gender, and ti...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Edmund Keogh Katelynn E Boerner Source Type: research

Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00410-5. doi: 10.1016/j.bbi.2023.12.028. Online ahead of print.ABSTRACTPost-operative cognitive dysfunction (POCD) is an abrupt decline in neurocognitive function arising shortly after surgery and persisting for weeks to months, increasing the risk of dementia diagnosis. Advanced age, obesity, and comorbidities linked to high-fat diet (HFD) consumption such as diabetes and hypertension have been identified as risk factors for POCD, although underlying mechanisms remain unclear. We have previously shown that surgery alone, or 3-days of HFD can each evoke sufficient neuroinflammat...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Stephanie M Muscat Michael J Butler Menaz N Bettes James DeMarsh Emmanuel A Scaria Nicholas P Deems Ruth M Barrientos Source Type: research

Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00409-9. doi: 10.1016/j.bbi.2023.12.027. Online ahead of print.ABSTRACTThe focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to: conceptual imprecision, research bias, limitations with binary descriptions, integrating sex and gender, and ti...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Edmund Keogh Katelynn E Boerner Source Type: research

Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00410-5. doi: 10.1016/j.bbi.2023.12.028. Online ahead of print.ABSTRACTPost-operative cognitive dysfunction (POCD) is an abrupt decline in neurocognitive function arising shortly after surgery and persisting for weeks to months, increasing the risk of dementia diagnosis. Advanced age, obesity, and comorbidities linked to high-fat diet (HFD) consumption such as diabetes and hypertension have been identified as risk factors for POCD, although underlying mechanisms remain unclear. We have previously shown that surgery alone, or 3-days of HFD can each evoke sufficient neuroinflammat...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Stephanie M Muscat Michael J Butler Menaz N Bettes James DeMarsh Emmanuel A Scaria Nicholas P Deems Ruth M Barrientos Source Type: research

Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion
Brain Behav Immun. 2023 Dec 22:S0889-1591(23)00407-5. doi: 10.1016/j.bbi.2023.12.025. Online ahead of print.ABSTRACTMicroglia, the resident immune cells of the central nervous system (CNS), play a major role in damage progression and tissue remodeling after acute CNS injury, including ischemic stroke (IS) and spinal cord injury (SCI). Understanding the molecular mechanisms regulating microglial responses to injury may thus reveal novel therapeutic targets to promote CNS repair. Here, we investigated the role of microglial tumor necrosis factor receptor 2 (TNFR2), a transmembrane receptor previously associated with pro-surv...
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Stefano Raffaele Estrid Thougaard Cathrine C H Laursen Han Gao Katrine M Andersen Pernille V Nielsen Natalia Ort í-Casañ Morten Blichfeldt-Eckhardt Simon Koch Milani Deb-Chatterji Tim Magnus Jane Stubbe Kirsten Madsen Morten Meyer Matilda Degn Ulrich L Source Type: research

An immunological puzzle: The adaptive immune system fuels Alzheimer's disease pathology
Brain Behav Immun. 2023 Dec 22:S0889-1591(23)00408-7. doi: 10.1016/j.bbi.2023.12.026. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by a concerning rise in prevalence. It is projected that the number of affected individuals will reach a staggering 150 million by 2050. While recent advancements in monoclonal antibodies targeting Aβ have shown some clinical effects, there is an urgent need for improved therapies to effectively address the impeding surge of AD patients worldwide. To achieve this, a deeper understanding of the intricate mechanisms underlying t...
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Lien Van Hoecke Jonas Castelein Junhua Xie Lore Van Acker Griet Van Imschoot Elien Van Wonterghem Ine Vlaeminck Daan Verhaege Wouter Claeys Keimpe Wierda Zsuzsanna Callaerts-Vegh Roosmarijn E Vandenbroucke Source Type: research

RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation
CONCLUSIONS: These findings indicate that RAGE in inflammatory cells is necessary to mediate stimuli of latent chronic inflammation that cause brain inflammation and cognitive decline, potentially by orchestrating monocyte activation via regulation of PSGL-1 expression. Our results also suggest esRAGE-mediated inflammatory regulation as a potential therapeutic option for cognitive dysfunction in MetS with latent chronic inflammation.PMID:38142917 | DOI:10.1016/j.bbi.2023.12.022 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Dasen Ye Akio Miyoshi Tomoe Ushitani Manabu Kadoya Masataka Igeta Kosuke Konishi Takuhito Shoji Koubun Yasuda Shiho Kitaoka Hideshi Yagi Etsushi Kuroda Yasuhiko Yamamoto Jidong Cheng Hidenori Koyama Source Type: research

Maternal selenium dietary supplementation alters sociability and reinforcement learning deficits induced by in utero exposure to maternal immune activation in mice
This study demonstrates that while Se may be beneficial in ameliorating sociability deficits caused by MIA, it may have negative effects in other behavioural domains. Caution in the use of Se supplementation during pregnancy is therefore warranted.PMID:38142918 | DOI:10.1016/j.bbi.2023.12.024 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Brendan Gillespie Michael J Houghton Katherine Ganio Christopher A McDevitt Daniel Bennett Ariel Dunn Sharvada Raju Anna Schroeder Rachel A Hill Barbara R Cardoso Source Type: research

Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease
In conclusion, high-fibre intake was effective in enhancing gastrointestinal function, cognition and affective behaviors in HD mice. These findings indicate that dietary fibre interventions may have therapeutic potential in Huntington's disease to delay clinical onset, and have implications for related disorders exhibiting dysfunction of the gut-brain axis.PMID:38142919 | DOI:10.1016/j.bbi.2023.12.023 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Carolina Gubert Geraldine Kong Callum Costello Cameron D Adams Bethany A Masson Wendy Qin Jocelyn Choo Vinod K Narayana Geraint Rogers Thibault Renoir John B Furness Anthony J Hannan Source Type: research

Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review
CONCLUSION: Results from several studies are consistent with the hypothesis that signals often classified as "proinflammatory" are elevated in threshold pediatric psychotic disorders. Data are less clear for immune markers in subthreshold psychosis and redox markers across the subthreshold and threshold psychosis spectrum. Immune and redox biomarker intervention studies are lacking, and research investigating interventions targeting the immune system in threshold pediatric psychosis is especially warranted.PMID:38141839 | DOI:10.1016/j.bbi.2023.12.019 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 23, 2023 Category: Neurology Authors: Jerome Henry Taylor Julieta Bermudez-Gomez Marina Zhou Oscar Gomez Casey Ganz-Leary Cesar Palacios Zeeshan M Huque Ran Barzilay David R Goldsmith Raquel E Gur Source Type: research