Peri-operative individually tailored psychological intervention in breast cancer patients improves psychological indices and molecular biomarkers of metastasis in excised tumors
Brain Behav Immun. 2024 Feb 10:S0889-1591(24)00245-9. doi: 10.1016/j.bbi.2024.02.009. Online ahead of print.ABSTRACTPerioperative stress and inflammatory signaling can invigorate pro-metastatic molecular processes in patients' tumors, potentially worsening long-term survival. Yet, it is unknown whether pre-operative psychotherapeutic interventions can attenuate such effects. Herein, three weeks before surgery, forty women diagnosed with stage I-III invasive ductal/lobular breast carcinoma were randomized to a 6-week one-on-one psychological intervention (6 meetings with a medical psychologist and bi-weekly phone calls) ver...
Source: Brain, Behavior, and Immunity - February 12, 2024 Category: Neurology Authors: Tsipi Hanalis-Miller Itay Ricon-Becker Nahida Sakis Estherina Trachtenberg Frida Ohayon Sonya Wadhawker Yehudit Birnboim Ada Magen Eran Sharon Ricardo Tarrasch Gil Goldzweig Steve W Cole Rebecca Jacoby Shamgar Ben-Eliyahu Source Type: research
From hormones to behavior through microglial mitochondrial function
Brain Behav Immun. 2024 Feb 8:S0889-1591(24)00248-4. doi: 10.1016/j.bbi.2024.02.012. Online ahead of print.NO ABSTRACTPMID:38341051 | DOI:10.1016/j.bbi.2024.02.012 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 10, 2024 Category: Neurology Authors: Maryam Ardalan Carina Mallard Source Type: research
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
Brain Behav Immun. 2024 Feb 8:S0889-1591(24)00243-5. doi: 10.1016/j.bbi.2024.02.007. Online ahead of print.ABSTRACTThe gut and brain are increasingly linked in human disease, with neuropsychiatric conditions classically attributed to the brain showing an involvement of the intestine and inflammatory bowel diseases (IBDs) displaying an ever-expanding list of neurological comorbidities. To identify molecular systems that underpin this gut-brain connection and thus discover therapeutic targets, experimental models of gut dysfunction must be evaluated for brain effects. In the present study, we examine disturbances along the g...
Source: Brain, Behavior, and Immunity - February 10, 2024 Category: Neurology Authors: Jake Sondag Boles Maeve E Krueger Janna E Jernigan Cassandra L Cole Noelle K Neighbarger Oihane Uriarte Huarte Mal ú Gámez Tansey Source Type: research
Role of pyroptosis in the pathogenesis of various neurological diseases
In conclusion, this review offers a comprehensive exploration of the role of pyroptosis in various neurological diseases, emphasizing its multifaceted molecular mechanisms within various CNS cell types. By elucidating the link between pyroptosis and chronic inflammation in the context of neurodegenerative disorders and infections, it provides valuable insights into potential therapeutic targets for mitigating these conditions.PMID:38336022 | DOI:10.1016/j.bbi.2024.02.001 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 9, 2024 Category: Neurology Authors: Abiola Oladapo Thomas Jackson Jueliet Menolascino Palsamy Periyasamy Source Type: research
Systemic inflammation and risk of Parkinson's disease: A prospective cohort study and genetic analysis
CONCLUSIONS: Systemic inflammation at baseline measured by CRP level is associated with decreased future risk of PD. These discoveries contribute to a deeper comprehension of the role of inflammation in the risk of PD, and hold implications for the design of therapeutic interventions in clinical trials.PMID:38336023 | DOI:10.1016/j.bbi.2024.02.013 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 9, 2024 Category: Neurology Authors: Chunyu Li Bin Ke Jianhai Chen Yi Xiao Shichan Wang Rirui Jiang Xiaoting Zheng Junyu Lin Jingxuan Huang Huifang Shang Source Type: research
Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity
Brain Behav Immun. 2024 Feb 8;117:456-470. doi: 10.1016/j.bbi.2024.02.008. Online ahead of print.ABSTRACTObesity has reached pandemic proportions and is a risk factor for neurodegenerative diseases, including Alzheimer's disease. Chronic inflammation is common in obese patients, but the mechanism between inflammation and cognitive impairment in obesity remains unclear. Accumulative evidence shows that protein-tyrosine phosphatase 1B (PTP1B), a neuroinflammatory and negative synaptic regulator, is involved in the pathogenesis of neurodegenerative processes. We investigated the causal role of PTP1B in obesity-induced cogniti...
Source: Brain, Behavior, and Immunity - February 9, 2024 Category: Neurology Authors: Xing Ge Minmin Hu Menglu Zhou Xiaoli Fang Xi Chen Deqin Geng Li Wang Xiaoying Yang Huimei An Meng Zhang Danhong Lin Mingxuan Zheng Xiaoying Cui Qing Wang Yuqing Wu Kuiyang Zheng Xu-Feng Huang Yinghua Yu Source Type: research
Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients
DISCUSSION: Prolonged systemic inflammation in critically ill COVID-19 patients is related to neuroaxonal damage and subsequent long-term cognitive impairment. Moreover, our findings suggest that plasma NfL concentrations during ICU stay may possess prognostic value in predicting future long-term cognitive impairment in patients that survived severe COVID-19.PMID:38336025 | DOI:10.1016/j.bbi.2024.02.002 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 9, 2024 Category: Neurology Authors: H B Duindam D Mengel M Kox J C G öpfert R P C Kessels M Synofzik P Pickkers W F Abdo Source Type: research
Type I interferons, inflammation, and fatigue in a longitudinal RNA study of women with breast cancer
CONCLUSIONS: Results revealed unexpected complexity in the immune underpinnings of CRF and identify a novel role for IFN signaling as a robust contributor to this symptom before, during, and after treatment. Pro-inflammatory gene expression emerged as a predictor of fatigue later in the cancer trajectory, and that effect was primarily accounted for by a concurrent increase in monocyte prevalence.PMID:38325563 | DOI:10.1016/j.bbi.2024.02.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 7, 2024 Category: Neurology Authors: Julienne E Bower Patricia A Ganz Michael R Irwin Catherine M Crespi Laura Petersen Arash Asher Sara A Hurvitz Steve W Cole Source Type: research
Midbrain FA initiates neuroinflammation and depression onset in both acute and chronic LPS-induced depressive model mice
In this study, we report that midbrain FA derived from lipopolysaccharide (LPS) is a direct trigger of depression. Using an acute depressive model in mice, we found that one-week intraperitoneal injection (i.p.) of LPS activated semicarbazide-sensitive amine oxidase (SSAO) leading to FA production from the midbrain vascular endothelium. In both in vitro and in vivo experiments, FA stimulated the production of cytokines such as IL-1β, IL-6, and TNF-α. Strikingly, one-week microinfusion of FA as well as LPS into the midbrain dorsal raphe nucleus (DRN, a 5-HT-nergic nucleus) induced depressive-like behaviors and concurrent ...
Source: Brain, Behavior, and Immunity - February 6, 2024 Category: Neurology Authors: Danrui Zhao Yiqing Wu Hang Zhao Fengji Zhang Junting Wang Yiying Liu Jing Lin Yirui Huang Wenhao Pan Jiahui Qi Nan Chen Xu Yang Wen Xu Zhiqian Tong Jianhua Cheng Source Type: research
Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice
CONCLUSIONS: Our results suggest that neurocognitive protection against SAE after hippocampal α2A-AR activation is astrocyte specific. This protection may involve the inhibition of astrocyte reactivity and alleviation of glutamate neurotoxicity, thereby reducing synaptic injury. The cAMP/protein kinase A (PKA) signaling pathway is a potential cellular mechanism by which activating α2A-AR modulates astrocytic function.PMID:38320682 | DOI:10.1016/j.bbi.2024.02.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 6, 2024 Category: Neurology Authors: Bin Mei Xiaoxia Xu Juntao Weng Yueyue Yang Peng Wang Gaolin Qiu Chi Zhang Qunlin Zhang Yao Lu Xuesheng Liu Source Type: research
Hyperactive lateral habenula mediates the comorbidity between rheumatoid arthritis and depression-like behaviors
Brain Behav Immun. 2024 Feb 4;117:412-427. doi: 10.1016/j.bbi.2024.02.006. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) patients have a high prevalence for depression. On the other hand, comorbid with depression is associated with worse prognosis for RA. However, little is known about the underlying mechanisms for the comorbidity between RA and depression. It remains to be elucidated which brain region is critically involved in the development of depression in RA, and whether alterations in the brain may affect pathological development of RA symptoms. Here, by combining clinical and animal model studies, we show...
Source: Brain, Behavior, and Immunity - February 6, 2024 Category: Neurology Authors: Peihui Wu Wenchang Li Rongke Lv Xin Cheng Fan Lian Wenbao Cai Yubo Hu Yanni Zeng Bizhen Ke Yi Chen Zaohui Ma Meiqi Ma Weiping Dai Pei Xia Yangyang Lin Wei-Jye Lin Xiaojing Ye Source Type: research
KCNA2 IgG autoimmunity in neuropsychiatric diseases
CONCLUSION: Our data suggest that KCNA2 autoimmunity is clinically heterogeneous. Future studies should determine whether KCNA2 autoantibodies are directly pathogenic or develop secondarily. Early immunotherapy should be considered, in particular if autoantibodies occur in CSF or if clinical or diagnostic findings suggest ongoing inflammation. Suspicious clinical phenotypes include autoimmune encephalitis, atypical dementia, new-onset epilepsy and unexplained epileptic seizures.PMID:38309639 | DOI:10.1016/j.bbi.2024.01.220 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 3, 2024 Category: Neurology Authors: Friederike A Arlt Ramona Miske Marie-Luise Machule Peter Broegger Christensen Swantje Mindorf Bianca Teegen Kathrin Borowski Maria Buthut Rosa R ößling Elisa S ánchez-Sendín Scott van Hoof C ésar Cordero-Gómez Isabel B ünger Helena Radbruch Andrea Source Type: research
Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
Brain Behav Immun. 2024 Feb 2;117:330-346. doi: 10.1016/j.bbi.2024.01.216. Online ahead of print.ABSTRACTNutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the H...
Source: Brain, Behavior, and Immunity - February 3, 2024 Category: Neurology Authors: Clara Sanchez C écilia Colson Nadine Gautier Pascal Noser Juliette Salvi Maxime Villet Lucile Fleuriot Caroline Peltier Pascal Schlich Fr édéric Brau Ariane Sharif Ali Altintas Ez-Zoubir Amri Jean-Louis Nahon Nicolas Blondeau Alexandre Benani Romain Ba Source Type: research
Macrophage is more than a bystander in peripheral sensitisation
Brain Behav Immun. 2024 Feb 1;117:310-311. doi: 10.1016/j.bbi.2024.01.223. Online ahead of print.NO ABSTRACTPMID:38307444 | DOI:10.1016/j.bbi.2024.01.223 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 2, 2024 Category: Neurology Authors: Philip Chiu-Tsun Tang Shujie Huang Patrick Ming-Kuen Tang Source Type: research
Response to comment on: Fibroblast-derived PI16 sustains inflammatory pain via regulation of CD206 < sup > + < /sup > myeloid cells
Brain Behav Immun. 2024 Feb 1;117:312. doi: 10.1016/j.bbi.2024.01.224. Online ahead of print.NO ABSTRACTPMID:38307445 | DOI:10.1016/j.bbi.2024.01.224 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 2, 2024 Category: Neurology Authors: Andrew J Shepherd Source Type: research
