The integrative single-case design in psychoneuroimmunology
Brain Behav Immun. 2024 Feb 15:S0889-1591(24)00246-0. doi: 10.1016/j.bbi.2024.02.010. Online ahead of print.NO ABSTRACTPMID:38367847 | DOI:10.1016/j.bbi.2024.02.010 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 17, 2024 Category: Neurology Authors: Christian Schubert Source Type: research
Early corticosteroid treatment enhances recovery from SARS-CoV-2 induced loss of smell in hamster
In this study, we explored its impact using hamster as an animal model. SARS-CoV-2 infected hamsters lose their smell abilities and this loss is correlated with damage of the olfactory epithelium and persistent presence of innate immunity cells. We started a dexamethasone treatment 2 days post infection, when olfaction was already impacted, until 11 days post infection when it started to recover. We observed an improvement of olfactory capacities in the animals treated with corticoid compared to those treated with vehicle. This recovery was not related to differences in the remaining damage to the olfactory epithelium, whi...
Source: Brain, Behavior, and Immunity - February 17, 2024 Category: Neurology Authors: Laetitia Merle-Nguyen Oph élie Ando-Grard Clara Bourgon Audrey St Albin Juliette Jacquelin Bernard Klonjkowski Sophie Le Poder Nicolas Meunier Source Type: research
Low-dose interleukin 2 antidepressant potentiation in unipolar and bipolar depression: Safety, efficacy, and immunological biomarkers
Brain Behav Immun. 2024 Feb 15:S0889-1591(24)00255-1. doi: 10.1016/j.bbi.2024.02.019. Online ahead of print.ABSTRACTImmune-inflammatory mechanisms are promising targets for antidepressant pharmacology. Immune cell abnormalities have been reported in mood disorders showing a partial T cell defect. Following this line of reasoning we defined an antidepressant potentiation treatment with add-on low-dose interleukin 2 (IL-2). IL-2 is a T-cell growth factor which has proven anti-inflammatory efficacy in autoimmune conditions, increasing thymic production of naïve CD4 + T cells, and possibly correcting the partial T cell defect...
Source: Brain, Behavior, and Immunity - February 17, 2024 Category: Neurology Authors: Sara Poletti Raffaella Zanardi Alessandra Mandelli Veronica Aggio Annamaria Finardi Cristina Lorenzi Giovanna Borsellino Matteo Carminati Elena Manfredi Enrico Tomasi Sara Spadini Cristina Colombo Hemmo A Drexhage Roberto Furlan Francesco Benedetti Source Type: research
The integrative single-case design in psychoneuroimmunology
Brain Behav Immun. 2024 Feb 15:S0889-1591(24)00246-0. doi: 10.1016/j.bbi.2024.02.010. Online ahead of print.NO ABSTRACTPMID:38367847 | DOI:10.1016/j.bbi.2024.02.010 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 17, 2024 Category: Neurology Authors: Christian Schubert Source Type: research
Toward a dynamic immunopsychiatry
Brain Behav Immun. 2024 Feb 14:S0889-1591(24)00247-2. doi: 10.1016/j.bbi.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38365011 | DOI:10.1016/j.bbi.2024.02.011 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 16, 2024 Category: Neurology Authors: Daniel P Moriarity George M Slavich Source Type: research
Affective dysfunction mediates the link between neuroimmune markers and the default mode network functional connectivity, and the somatic symptoms in somatic symptom disorder
CONCLUSIONS: Affective symptoms may indirectly mediate the associations between DMN connectivity, somatic symptoms, and neuroimmune markers. Inflammatory markers may also mediate the impact of DMN connectivity on affective symptoms. These results emphasize the importance of affective dysregulation in understanding the mechanisms of SSD and have potential implications for the development of tailored therapeutic approaches for SSD patients with affective symptoms. Furthermore, in SSD research using DMN FC or neuroimmune markers, considering and incorporating such mediating effects of affective symptoms suggests the possibili...
Source: Brain, Behavior, and Immunity - February 15, 2024 Category: Neurology Authors: Bumhee Park Seulgi Lee Yu Na Jang Hye Youn Park Source Type: research
The miR-25802/KLF4/NF- κB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer's disease
This study identified a novel microRNA termed miR-25802 from our high-throughput sequencing dataset of an AD model and explored its role and the underlying mechanism. The results confirmed the miRNA properties of miR-25802 based on bioinformatics and experimental verification. Expression of miR-25802 was increased in the plasma of AD patients and in the hippocampus of APP/PS1 and 5 × FAD mice carrying two and five familial AD gene mutations. Functional studies suggested that overexpression or inhibition of miR-25802 respectively aggravated or ameliorated AD-related pathology, including cognitive disability, Aβ deposition...
Source: Brain, Behavior, and Immunity - February 15, 2024 Category: Neurology Authors: Kaiyue Zhao Jianghong Liu Ting Sun Li Zeng Zhongdi Cai Zhuorong Li Rui Liu Source Type: research
Interferon- β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV
Brain Behav Immun. 2024 Feb 13:S0889-1591(24)00250-2. doi: 10.1016/j.bbi.2024.02.014. Online ahead of print.ABSTRACTHuman immunodeficiency virus-1 (HIV-1) infects the central nervous system (CNS) and causes HIV-associated neurocognitive disorders (HAND) in about half of the population living with the virus despite combination anti-retroviral therapy (cART). HIV-1 activates the innate immune system, including the production of type 1 interferons (IFNs) α and β. Transgenic mice expressing HIV-1 envelope glycoprotein gp120 (HIVgp120tg) in the CNS develop memory impairment and share key neuropathological features and differe...
Source: Brain, Behavior, and Immunity - February 15, 2024 Category: Neurology Authors: Hina Singh Jeffrey Koury Ricky Maung Amanda J Roberts Marcus Kaul Source Type: research
Affective dysfunction mediates the link between neuroimmune markers and the default mode network functional connectivity, and the somatic symptoms in somatic symptom disorder
CONCLUSIONS: Affective symptoms may indirectly mediate the associations between DMN connectivity, somatic symptoms, and neuroimmune markers. Inflammatory markers may also mediate the impact of DMN connectivity on affective symptoms. These results emphasize the importance of affective dysregulation in understanding the mechanisms of SSD and have potential implications for the development of tailored therapeutic approaches for SSD patients with affective symptoms. Furthermore, in SSD research using DMN FC or neuroimmune markers, considering and incorporating such mediating effects of affective symptoms suggests the possibili...
Source: Brain, Behavior, and Immunity - February 15, 2024 Category: Neurology Authors: Bumhee Park Seulgi Lee Yu Na Jang Hye Youn Park Source Type: research
The miR-25802/KLF4/NF- κB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer's disease
This study identified a novel microRNA termed miR-25802 from our high-throughput sequencing dataset of an AD model and explored its role and the underlying mechanism. The results confirmed the miRNA properties of miR-25802 based on bioinformatics and experimental verification. Expression of miR-25802 was increased in the plasma of AD patients and in the hippocampus of APP/PS1 and 5 × FAD mice carrying two and five familial AD gene mutations. Functional studies suggested that overexpression or inhibition of miR-25802 respectively aggravated or ameliorated AD-related pathology, including cognitive disability, Aβ deposition...
Source: Brain, Behavior, and Immunity - February 15, 2024 Category: Neurology Authors: Kaiyue Zhao Jianghong Liu Ting Sun Li Zeng Zhongdi Cai Zhuorong Li Rui Liu Source Type: research
Interferon- β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV
Brain Behav Immun. 2024 Feb 13:S0889-1591(24)00250-2. doi: 10.1016/j.bbi.2024.02.014. Online ahead of print.ABSTRACTHuman immunodeficiency virus-1 (HIV-1) infects the central nervous system (CNS) and causes HIV-associated neurocognitive disorders (HAND) in about half of the population living with the virus despite combination anti-retroviral therapy (cART). HIV-1 activates the innate immune system, including the production of type 1 interferons (IFNs) α and β. Transgenic mice expressing HIV-1 envelope glycoprotein gp120 (HIVgp120tg) in the CNS develop memory impairment and share key neuropathological features and differe...
Source: Brain, Behavior, and Immunity - February 15, 2024 Category: Neurology Authors: Hina Singh Jeffrey Koury Ricky Maung Amanda J Roberts Marcus Kaul Source Type: research
Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia
CONCLUSION: This MR study utilised multiple MR methods to obtain results suggesting bidirectional genetic genetically-predicted relationships for elevated lymphocyte counts and schizophrenia risk. In addition, moderate evidence also showed bidirectional genetically-predicted relationships between schizophrenia and monocyte counts, and unidirectional effect from genetic liability for eosinophil count to schizophrenia and from genetic liability for schizophrenia to neutrophil count. The influence of schizophrenia to eosinophil count is less certain. Our findings support the role of WBC in schizophrenia and concur with the hy...
Source: Brain, Behavior, and Immunity - February 14, 2024 Category: Neurology Authors: Perry B M Leung Zipeng Liu Yuanxin Zhong Justin D Tubbs Marta Di Forti Robin M Murray Hon- Cheong So Pak C Sham Simon S Y Lui Source Type: research
Associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough SARS-CoV-2 infection: The VENUS Study
CONCLUSIONS: This is the first study to demonstrate that the associations between COVID-19 vaccination and post-COVID psychiatric disorders vary among the different variant periods. Future studies on these associations should be conducted with consideration to the prevalent circulating variants.PMID:38355026 | DOI:10.1016/j.bbi.2024.02.018 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 14, 2024 Category: Neurology Authors: Fumiko Murata Megumi Maeda Keitaro Murayama Tomohiro Nakao Haruhisa Fukuda Source Type: research
Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia
CONCLUSION: This MR study utilised multiple MR methods to obtain results suggesting bidirectional genetic genetically-predicted relationships for elevated lymphocyte counts and schizophrenia risk. In addition, moderate evidence also showed bidirectional genetically-predicted relationships between schizophrenia and monocyte counts, and unidirectional effect from genetic liability for eosinophil count to schizophrenia and from genetic liability for schizophrenia to neutrophil count. The influence of schizophrenia to eosinophil count is less certain. Our findings support the role of WBC in schizophrenia and concur with the hy...
Source: Brain, Behavior, and Immunity - February 14, 2024 Category: Neurology Authors: Perry B M Leung Zipeng Liu Yuanxin Zhong Justin D Tubbs Marta Di Forti Robin M Murray Hon- Cheong So Pak C Sham Simon S Y Lui Source Type: research
Associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough SARS-CoV-2 infection: The VENUS Study
CONCLUSIONS: This is the first study to demonstrate that the associations between COVID-19 vaccination and post-COVID psychiatric disorders vary among the different variant periods. Future studies on these associations should be conducted with consideration to the prevalent circulating variants.PMID:38355026 | DOI:10.1016/j.bbi.2024.02.018 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 14, 2024 Category: Neurology Authors: Fumiko Murata Megumi Maeda Keitaro Murayama Tomohiro Nakao Haruhisa Fukuda Source Type: research
