Diurnal cortisol, neuroinflammation, and neuroimaging visual rating scales in memory clinic patients
CONCLUSION: This study suggests an interplay between diurnal cortisol patterns and neuroinflammation in relation to brain structure. While this cross-sectional study does not provide information on causality or temporality, these findings suggest that neuroinflammation may be involved in the relationship between HPA-axis functioning and AD.PMID:38503394 | DOI:10.1016/j.bbi.2024.03.024 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 19, 2024 Category: Neurology Authors: Jasper Holleman Makrina Daniilidou Ingemar K åreholt Malin Asp ö G öran Hagman Chinedu T Udeh-Momoh Gabriela Spulber Miia Kivipelto Alina Solomon Anna Matton Shireen Sindi Source Type: research
A single bout of vigorous intensity exercise enhances the efficacy of rituximab against autologous human chronic lymphocytic leukaemia B-cells ex vivo
Brain Behav Immun. 2024 Mar 17:S0889-1591(24)00304-0. doi: 10.1016/j.bbi.2024.03.023. Online ahead of print.ABSTRACTChronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease eradication, due in part to failure of antibody-dependent cellular cytotoxicity which relies on natural killer (NK)-cells binding to rituximab-bound CD20 on B-cells. CLL cells are diffusely spread across lymphoid and other bodily tissues, and ADCC resistance in s...
Source: Brain, Behavior, and Immunity - March 19, 2024 Category: Neurology Authors: Harrison D Collier-Bain Annabelle Emery Adam J Causer Frankie F Brown Rebecca Oliver David Dutton Josephine Crowe Daniel Augustine John Graby Shoji Leach Rachel Eddy Daniela Rothschild-Rodriguez Juliet C Gray Mark S Cragg Kirstie L Cleary Sally Moore Jame Source Type: research
Diurnal cortisol, neuroinflammation, and neuroimaging visual rating scales in memory clinic patients
CONCLUSION: This study suggests an interplay between diurnal cortisol patterns and neuroinflammation in relation to brain structure. While this cross-sectional study does not provide information on causality or temporality, these findings suggest that neuroinflammation may be involved in the relationship between HPA-axis functioning and AD.PMID:38503394 | DOI:10.1016/j.bbi.2024.03.024 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 19, 2024 Category: Neurology Authors: Jasper Holleman Makrina Daniilidou Ingemar K åreholt Malin Asp ö G öran Hagman Chinedu T Udeh-Momoh Gabriela Spulber Miia Kivipelto Alina Solomon Anna Matton Shireen Sindi Source Type: research
A single bout of vigorous intensity exercise enhances the efficacy of rituximab against autologous human chronic lymphocytic leukaemia B-cells ex vivo
Brain Behav Immun. 2024 Mar 17:S0889-1591(24)00304-0. doi: 10.1016/j.bbi.2024.03.023. Online ahead of print.ABSTRACTChronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease eradication, due in part to failure of antibody-dependent cellular cytotoxicity which relies on natural killer (NK)-cells binding to rituximab-bound CD20 on B-cells. CLL cells are diffusely spread across lymphoid and other bodily tissues, and ADCC resistance in s...
Source: Brain, Behavior, and Immunity - March 19, 2024 Category: Neurology Authors: Harrison D Collier-Bain Annabelle Emery Adam J Causer Frankie F Brown Rebecca Oliver David Dutton Josephine Crowe Daniel Augustine John Graby Shoji Leach Rachel Eddy Daniela Rothschild-Rodriguez Juliet C Gray Mark S Cragg Kirstie L Cleary Sally Moore Jame Source Type: research
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine
In conclusion, high-dose EPA has significantly reduced migraine frequency and severity, improved psychological symptoms and quality of life in EM patients, and shown no major adverse events, suggesting its potential as a prophylactic for EM.PMID:38499208 | DOI:10.1016/j.bbi.2024.03.019 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 18, 2024 Category: Neurology Authors: Hsueh-Fang Wang Wen-Chun Liu Halliru Zailani Cheng-Chia Yang Ting-Bin Chen Ching-Mao Chang I-Ju Tsai Chun-Pai Yang Kuan-Pin Su Source Type: research
Infraorbital nerve injury triggers sex-specific neuroimmune responses in the peripheral trigeminal pathway and common pain behaviours
This study sought empirical evidence for such assumptions using the infraorbital nerve chronic constriction model (ION-CCI). We compared the behavioural consequences of nerve constriction with: (i) the temporal patterns of recruitment of macrophages and T-lymphocytes at the site of nerve injury and in the trigeminal ganglion; and (ii) the degree of demyelination and axonal reorganisation in the injured nerve. Our data demonstrated that simply testing for allodynia and hyperalgesia as is done in extra-cephalic neuropathic pain models does not provide access to the range of injury-specific nociceptive responses and behaviour...
Source: Brain, Behavior, and Immunity - March 18, 2024 Category: Neurology Authors: James W M Kang Olivia I Davanzo Gaelle M Emvalomenos Richelle Mychasiuk Luke A Henderson Kevin A Keay Source Type: research
Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice
Brain Behav Immun. 2024 Mar 16:S0889-1591(24)00302-7. doi: 10.1016/j.bbi.2024.03.021. Online ahead of print.ABSTRACTSystemic activation of toll-like receptor 3 (TLR3) signaling using poly(I:C), a TLR3 agonist, drives ethanol consumption in several rodent models, while global knockout of Tlr3 reduces drinking in C57BL/6J male mice. To determine if brain TLR3 pathways are involved in drinking behavior, we used CRISPR/Cas9 genome editing to generate a Tlr3 floxed (Tlr3F/F) mouse line. After sequence confirmation and functional validation of Tlr3 brain transcripts, we injected Tlr3F/F male mice with an adeno-associated virus e...
Source: Brain, Behavior, and Immunity - March 18, 2024 Category: Neurology Authors: Geoffrey A Dilly Yuri A Blednov Anna S Warden Lubov Ezerskiy Caleb Fleischer Jesse D Plotkin Shruti Patil Elizabeth A Osterndorff-Kahanek Jody Mayfield R Dayne Mayfield Gregg E Homanics Robert O Messing Source Type: research
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine
In conclusion, high-dose EPA has significantly reduced migraine frequency and severity, improved psychological symptoms and quality of life in EM patients, and shown no major adverse events, suggesting its potential as a prophylactic for EM.PMID:38499208 | DOI:10.1016/j.bbi.2024.03.019 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 18, 2024 Category: Neurology Authors: Hsueh-Fang Wang Wen-Chun Liu Halliru Zailani Cheng-Chia Yang Ting-Bin Chen Ching-Mao Chang I-Ju Tsai Chun-Pai Yang Kuan-Pin Su Source Type: research
Infraorbital nerve injury triggers sex-specific neuroimmune responses in the peripheral trigeminal pathway and common pain behaviours
This study sought empirical evidence for such assumptions using the infraorbital nerve chronic constriction model (ION-CCI). We compared the behavioural consequences of nerve constriction with: (i) the temporal patterns of recruitment of macrophages and T-lymphocytes at the site of nerve injury and in the trigeminal ganglion; and (ii) the degree of demyelination and axonal reorganisation in the injured nerve. Our data demonstrated that simply testing for allodynia and hyperalgesia as is done in extra-cephalic neuropathic pain models does not provide access to the range of injury-specific nociceptive responses and behaviour...
Source: Brain, Behavior, and Immunity - March 18, 2024 Category: Neurology Authors: James W M Kang Olivia I Davanzo Gaelle M Emvalomenos Richelle Mychasiuk Luke A Henderson Kevin A Keay Source Type: research
Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice
Brain Behav Immun. 2024 Mar 16:S0889-1591(24)00302-7. doi: 10.1016/j.bbi.2024.03.021. Online ahead of print.ABSTRACTSystemic activation of toll-like receptor 3 (TLR3) signaling using poly(I:C), a TLR3 agonist, drives ethanol consumption in several rodent models, while global knockout of Tlr3 reduces drinking in C57BL/6J male mice. To determine if brain TLR3 pathways are involved in drinking behavior, we used CRISPR/Cas9 genome editing to generate a Tlr3 floxed (Tlr3F/F) mouse line. After sequence confirmation and functional validation of Tlr3 brain transcripts, we injected Tlr3F/F male mice with an adeno-associated virus e...
Source: Brain, Behavior, and Immunity - March 18, 2024 Category: Neurology Authors: Geoffrey A Dilly Yuri A Blednov Anna S Warden Lubov Ezerskiy Caleb Fleischer Jesse D Plotkin Shruti Patil Elizabeth A Osterndorff-Kahanek Jody Mayfield R Dayne Mayfield Gregg E Homanics Robert O Messing Source Type: research
Association between racial discrimination and CTRA expression following trauma exposure provides further context for health inequities and the weathering hypothesis
Brain Behav Immun. 2024 Mar 14;118:364-365. doi: 10.1016/j.bbi.2024.03.020. Online ahead of print.NO ABSTRACTPMID:38492759 | DOI:10.1016/j.bbi.2024.03.020 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 16, 2024 Category: Neurology Authors: Brooke G McKenna Patricia A Brennan Source Type: research
Association between racial discrimination and CTRA expression following trauma exposure provides further context for health inequities and the weathering hypothesis
Brain Behav Immun. 2024 Mar 14;118:364-365. doi: 10.1016/j.bbi.2024.03.020. Online ahead of print.NO ABSTRACTPMID:38492759 | DOI:10.1016/j.bbi.2024.03.020 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 16, 2024 Category: Neurology Authors: Brooke G McKenna Patricia A Brennan Source Type: research
Corrigendum to "INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats" [Brain Behav. Immun. 91 (2021) 587-600]
Brain Behav Immun. 2024 Mar 14:S0889-1591(24)00292-7. doi: 10.1016/j.bbi.2024.03.011. Online ahead of print.NO ABSTRACTPMID:38490921 | DOI:10.1016/j.bbi.2024.03.011 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 15, 2024 Category: Neurology Authors: Xiao Hu Jun Yan Lei Huang Camila Araujo Jun Peng Ling Gao Shengpeng Liu Jiping Tang Gang Zuo John H Zhang Source Type: research
Corrigendum to "INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats" [Brain Behav. Immun. 91 (2021) 587-600]
Brain Behav Immun. 2024 Mar 14:S0889-1591(24)00292-7. doi: 10.1016/j.bbi.2024.03.011. Online ahead of print.NO ABSTRACTPMID:38490921 | DOI:10.1016/j.bbi.2024.03.011 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 15, 2024 Category: Neurology Authors: Xiao Hu Jun Yan Lei Huang Camila Araujo Jun Peng Ling Gao Shengpeng Liu Jiping Tang Gang Zuo John H Zhang Source Type: research
Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia
Brain Behav Immun. 2024 Mar 12:S0889-1591(24)00298-8. doi: 10.1016/j.bbi.2024.03.017. Online ahead of print.ABSTRACTComplement is dysregulated in the brain in Alzheimer's Disease and in mouse models of Alzheimer's disease. Each of the complement derived effectors, opsonins, anaphylatoxins and membrane attack complex (MAC), have been implicated as drivers of disease but their relative contributions remain unclarified. Here we have focussed on the MAC, a lytic and pro-inflammatory effector, in the AppNL-G-F mouse amyloidopathy model. To test the role of MAC, we back-crossed to generate AppNL-G-F mice deficient in C7, an esse...
Source: Brain, Behavior, and Immunity - March 14, 2024 Category: Neurology Authors: Wioleta M Zelek Ryan J Bevan B Paul Morgan Source Type: research
