PTSD increases risk for major adverse cardiovascular events through neural and cardio-inflammatory pathways
This study included N = 118,827 participants from a large hospital-based biobank. Demographic, diagnostic, and medical history data collected from the biobank. SNA (n = 1,520), heart rate variability (HRV; [n = 11,463]), and high sensitivity C-reactive protein (hs-CRP; [n = 15,164]) were obtained for a subset of participants. PTSD predicted MACE after adjusting for traditional MACE risk factors (hazard ratio (HR) [95 % confidence interval (CI)] = 1.317 [1.098, 1.580], β = 0.276, p = 0.003). The PTSD-to-MACE association was mediated by SNA (CI = 0.005, 0.133, p < 0.05), HRV (CI = 0.024, 0.056, p < 0.05), and hs-CRP (...
Source: Brain, Behavior, and Immunity - January 13, 2024 Category: Neurology Authors: Antonia V Seligowski Simran S Grewal Shady Abohashem Hadil Zureigat Iqra Qamar Wesam Aldosoky Charbel Gharios Erin Hanlon Omar Alani Sandeep C Bollepalli Antonis Armoundas Zahi A Fayad Lisa M Shin Michael T Osborne Ahmed Tawakol Source Type: research
Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN- γ and PHGDH as a metabolic checkpoint of microglia polarization
Brain Behav Immun. 2024 Jan 11;117:155-166. doi: 10.1016/j.bbi.2024.01.009. Online ahead of print.ABSTRACTA "switch" in the metabolic pattern of microglia is considered to be required to meet the metabolic demands of cell survival and functions. However, how metabolic switches regulate microglial function remains controversial. We found here that exposure to amyloid-β triggers microglial inflammation accompanied by increasing GAPDH levels. The increase of GAPDH, a glycolysis enzyme, leads to the reduced release of interferon-γ (IFN-γ) from inflammatory microglia. Such alternation is translational and is regulated by the...
Source: Brain, Behavior, and Immunity - January 12, 2024 Category: Neurology Authors: Shangchen Yang Ziqi Yuan Yufei Zhu Chensi Liang Zhenlei Chen Jie Zhang Lige Leng Source Type: research
ROCK2 regulates microglia proliferation and neuronal survival after traumatic brain injury
Brain Behav Immun. 2024 Jan 10;117:181-194. doi: 10.1016/j.bbi.2024.01.004. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) results in prolonged and non-resolving activation of microglia. Forced turnover of these cells during the acute phase of TBI aids recovery, but the cell-intrinsic pathways that underpin the pro-repair phenotype of these repopulating microglia remain unclear. Here, we show that selective targeting of ROCK2 with the small molecule inhibitor KD025 impairs the proliferative response of microglia after TBI as well as during genetically induced turnover of microglia. KD025 treatment abolished the...
Source: Brain, Behavior, and Immunity - January 11, 2024 Category: Neurology Authors: Emily F Willis Seung Jae Kim Wei Chen Melanie Nyuydzefe Kelli P A MacDonald Alexandra Zanin-Zhorov Marc J Ruitenberg Jana Vukovic Source Type: research
Microbiota-microglia crosstalk between Blautia producta and neuroinflammation of Parkinson's disease: A bench-to-bedside translational approach
Brain Behav Immun. 2024 Jan 9;117:270-282. doi: 10.1016/j.bbi.2024.01.010. Online ahead of print.ABSTRACTParkinson's disease (PD) is intricately linked to abnormal gut microbiota, yet the specific microbiota influencing clinical outcomes remain poorly understood. Our study identified a deficiency in the microbiota genus Blautia and a reduction in fecal short-chain fatty acid (SCFA) butyrate level in PD patients compared to healthy controls. The abundance of Blautia correlated with the clinical severity of PD. Supplementation with butyrate-producing bacterium B. producta demonstrated neuroprotective effects, attenuating neu...
Source: Brain, Behavior, and Immunity - January 11, 2024 Category: Neurology Authors: Jiaming Liu Xinhuang Lv Tao Ye Ming Zhao Zhibo Chen Yang Zhang Wenwen Yang Huijia Xie Lu Zhan Liuzhu Chen Wen-Chun Liu Kuan-Pin Su Jing Sun Source Type: research
Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis
Brain Behav Immun. 2024 Jan 9;117:135-148. doi: 10.1016/j.bbi.2024.01.005. Online ahead of print.ABSTRACTThe mammalian hippocampus can generate new neurons throughout life. Known as adult hippocampal neurogenesis (AHN), this process participates in learning, memory, mood regulation, and forgetting. The continuous incorporation of new neurons enhances the plasticity of the hippocampus and contributes to the cognitive reserve in aged individuals. However, the integrity of AHN is targeted by numerous pathological conditions, including neurodegenerative diseases and sustained inflammation. In this regard, the latter causes cog...
Source: Brain, Behavior, and Immunity - January 11, 2024 Category: Neurology Authors: Carla B Rodr íguez-Moreno H éctor Cañeque-Rufo Miguel Flor-Garc ía Julia Terreros-Roncal Elena P Moreno-Jim énez Noem í Pallas-Bazarra Carlo Bressa Mar Larrosa Fabio Cafini Mar ía Llorens-Martín Source Type: research
Blocking IL-17A prevents oxycodone-ineduced depression-like effects and elevation of IL-6 levels in the ventral tegmental area and reduces oxycodone-derived physical dependence in rats
Brain Behav Immun. 2024 Jan 8;117:100-111. doi: 10.1016/j.bbi.2024.01.001. Online ahead of print.ABSTRACTOxycodone is the most prescribed opioid for pain management and has been available in clinics for almost a century, but effects of chronic oxycodone have been studied less than morphine in preclinical and clinical studies. Newly developed depression has been coupled with chronic oxycodone use in a few clinical studies, but no preclinical studies have investigated the pathogenesis of oxycodone-induced depression. Gut microbiome changes following oxycodone use is an understudied area, and interleukin-17A (IL-17A) is linke...
Source: Brain, Behavior, and Immunity - January 10, 2024 Category: Neurology Authors: Saadet Inan Joseph J Meissler Shingo Bessho Sonita Wiah Cagla Tukel Toby K Eisenstein Scott M Rawls Source Type: research
Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn
Brain Behav Immun. 2024 Jan 6;117:80-99. doi: 10.1016/j.bbi.2024.01.002. Online ahead of print.ABSTRACTEmerging studies have demonstrated spinal microglia play a critical role in central sensitization and contribute to chronic pain. Although several mediators that contribute to microglia activation have been identified, the mechanism of microglia activation and its functionally diversified mechanisms in pathological pain are still unclear. Here we report that injured sensory neurons-derived Galectin-3 (Gal3) activates and reprograms microglia in the spinal dorsal horn (SDH) and contributes to neuropathic pain. Firstly, Gal...
Source: Brain, Behavior, and Immunity - January 8, 2024 Category: Neurology Authors: Leyan Shan Kangtai Xu Luyao Ji Qian Zeng Yaqi Liu Yifei Wu Yiming Chen Yitong Li Qiaodan Hu Jiawei Wu Yuanfan Xu Yuhui Luo Changlin Li Chaoran Wu Changyu Jiang Zilong Wang Source Type: research
Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice
Brain Behav Immun. 2024 Jan 6;117:51-65. doi: 10.1016/j.bbi.2024.01.003. Online ahead of print.ABSTRACTMicroglia, resident immune cells in the central nervous system, play a role in neuroinflammation and the development of neuropathic pain. We found that the stimulator of interferon genes (STING) is predominantly expressed in spinal microglia and upregulated after peripheral nerve injury. However, mechanical allodynia, as a marker of neuropathic pain following peripheral nerve injury, did not require microglial STING expression. In contrast, STING activation by specific agonists (ADU-S100, 35 nmol) significantly alleviated...
Source: Brain, Behavior, and Immunity - January 8, 2024 Category: Neurology Authors: Arthur Silveira Prudente Sang Hoon Lee Jueun Roh Debora D Luckemeyer Cinder F Cohen Marie Pertin Chul-Kyu Park Marc R Suter Isabelle Decosterd Jun-Ming Zhang Ru-Rong Ji Temugin Berta Source Type: research
Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn
Brain Behav Immun. 2024 Jan 6:S0889-1591(24)00002-3. doi: 10.1016/j.bbi.2024.01.002. Online ahead of print.ABSTRACTEmerging studies have demonstrated spinal microglia play a critical role in central sensitization and contribute to chronic pain. Although several mediators that contribute to microglia activation have been identified, the mechanism of microglia activation and its functionally diversified mechanisms in pathological pain are still unclear. Here we report that injured sensory neurons-derived Galectin-3 (Gal3) activates and reprograms microglia in the spinal dorsal horn (SDH) and contributes to neuropathic pain. ...
Source: Brain, Behavior, and Immunity - January 8, 2024 Category: Neurology Authors: Leyan Shan Kangtai Xu Luyao Ji Qian Zeng Yaqi Liu Yifei Wu Yiming Chen Yitong Li Qiaodan Hu Jiawei Wu Yuanfan Xu Yuhui Luo Changlin Li Chaoran Wu Changyu Jiang Zilong Wang Source Type: research
Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice
Brain Behav Immun. 2024 Jan 6:S0889-1591(24)00003-5. doi: 10.1016/j.bbi.2024.01.003. Online ahead of print.ABSTRACTMicroglia, resident immune cells in the central nervous system, play a role in neuroinflammation and the development of neuropathic pain. We found that the stimulator of interferon genes (STING) is predominantly expressed in spinal microglia and upregulated after peripheral nerve injury. However, mechanical allodynia, as a marker of neuropathic pain following peripheral nerve injury, did not require microglial STING expression. In contrast, STING activation by specific agonists (ADU-S100, 35 nmol) significantl...
Source: Brain, Behavior, and Immunity - January 8, 2024 Category: Neurology Authors: Arthur Silveira Prudente Sang Hoon Lee Jueun Roh Debora D Luckemeyer Cinder Faith Cohen Marie Pertin Chul-Kyu Park Marc R Suter Isabelle Decosterd Jun-Ming Zhang Ru-Rong Ji Temugin Berta Source Type: research
Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice
Brain Behav Immun. 2024 Jan 3:S0889-1591(23)00415-4. doi: 10.1016/j.bbi.2023.12.033. Online ahead of print.ABSTRACTRisk factors contributing to dementia are multifactorial. Accumulating evidence suggests a role for pathogens as risk factors, but data is largely correlative with few causal relationships. Here, we demonstrate that intermittent murine cytomegalovirus (MCMV) infection of mice, alters blood brain barrier (BBB) permeability and metabolic pathways. Increased basal mitochondrial function is observed in brain microvessels cells (BMV) exposed to intermittent MCMV infection and is accompanied by elevated levels of su...
Source: Brain, Behavior, and Immunity - January 5, 2024 Category: Neurology Authors: Mark A A Harrison Sara L Morris Grace A Rudman Daniel J Rittenhouse Chandler H Monk Siva S V P Sakamuri Md Mehedi Hasan Mst Shamima Khatun Hanyun Wang Lucas P Garfinkel Elizabeth B Norton Sangku Kim Jay K Kolls S Michal Jazwinski Ricardo Mostany Prasad V Source Type: research
Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice
Brain Behav Immun. 2024 Jan 3:S0889-1591(23)00415-4. doi: 10.1016/j.bbi.2023.12.033. Online ahead of print.ABSTRACTRisk factors contributing to dementia are multifactorial. Accumulating evidence suggests a role for pathogens as risk factors, but data is largely correlative with few causal relationships. Here, we demonstrate that intermittent murine cytomegalovirus (MCMV) infection of mice, alters blood brain barrier (BBB) permeability and metabolic pathways. Increased basal mitochondrial function is observed in brain microvessels cells (BMV) exposed to intermittent MCMV infection and is accompanied by elevated levels of su...
Source: Brain, Behavior, and Immunity - January 5, 2024 Category: Neurology Authors: Mark A A Harrison Sara L Morris Grace A Rudman Daniel J Rittenhouse Chandler H Monk Siva S V P Sakamuri Md Mehedi Hasan Mst Shamima Khatun Hanyun Wang Lucas P Garfinkel Elizabeth B Norton Sangku Kim Jay K Kolls S Michal Jazwinski Ricardo Mostany Prasad V Source Type: research
Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study
CONCLUSIONS: CHR and non-converters demonstrated significantly larger ChP volumes compared to controls. Enlarged ChP was associated with neuroanatomical alterations and analyte markers functionally associated with the ChP. These findings suggest that the ChP may be a key an important biomarker in CHR.PMID:38169244 | DOI:10.1016/j.bbi.2023.12.021 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 3, 2024 Category: Neurology Authors: Deepthi Bannai Martin Reuter Rachal Hegde Dung Hoang Iniya Adhan Swetha Gandu Sovannarath Pong Nick Raymond Victor Zeng Yoonho Chung George He Daqiang Sun Theo G M van Erp Jean Addington Carrie E Bearden Kristin Cadenhead Barbara Cornblatt Daniel H Mathal Source Type: research
Association between doxycycline use and long-term functioning in patients with schizophrenia
CONCLUSIONS: In this observational study, doxycycline exposure is associated with a reduced incidence of disability pension. These data support further studies on the potential long term neuroprotective effects of doxycycline and level of functioning in schizophrenia patients.PMID:38169245 | DOI:10.1016/j.bbi.2023.12.036 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 3, 2024 Category: Neurology Authors: Lot D de Witte Thomas Munk Laursen Cheryl M Corcoran Trine Munk-Olsen Veerle Bergink Source Type: research
Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study
CONCLUSIONS: CHR and non-converters demonstrated significantly larger ChP volumes compared to controls. Enlarged ChP was associated with neuroanatomical alterations and analyte markers functionally associated with the ChP. These findings suggest that the ChP may be a key an important biomarker in CHR.PMID:38169244 | DOI:10.1016/j.bbi.2023.12.021 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 3, 2024 Category: Neurology Authors: Deepthi Bannai Martin Reuter Rachal Hegde Dung Hoang Iniya Adhan Swetha Gandu Sovannarath Pong Nick Raymond Victor Zeng Yoonho Chung George He Daqiang Sun Theo G M van Erp Jean Addington Carrie E Bearden Kristin Cadenhead Barbara Cornblatt Daniel H Mathal Source Type: research